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https://www.readbyqxmd.com/read/28797568/the-combination-of-a-966492-and-topotecan-for-effective-radiosensitization-on-glioblastoma-spheroids
#1
Fereshteh Koosha, Ali Neshasteh-Riz, Abbas Takavar, Nazila Eyvazzadeh, Zohreh Mazaheri, Samira Eynali, Mehdi Mousavi
Radiotherapy is one of the modalities in the treatment of glioblastoma patients, but glioma tumors are resistant to radiation and also chemotherapy drugs. Thus, researchers are investigating drugs which have radiosensitization capabilities in order to improve radiotherapy. PARP enzymes and topoisomerase I enzymes have a critical role in repairing DNA damage in tumor cells. Thus, inhibiting activity of these enzymes helps stop DNA damage repair and increase DSB lethal damages. In the current study, we investigated the combination of TPT as a topoisomerase I inhibitor, and A-966492 as a novel PARP inhibitor for further radiosensitization...
August 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28776326/a-comprehensive-pipeline-for-multi-resolution-modeling-of-the-mitral-valve-validation-computational-efficiency-and-predictive-capability
#2
Andrew Drach, Amir H Khalighi, Michael S Sacks
Multiple studies have demonstrated that the pathological geometries unique to each patient can affect the durability of mitral valve (MV) repairs. While computational modeling of the MV is a promising approach to improve the surgical outcomes, the complex MV geometry precludes use of simplified models. Moreover, the lack of complete in-vivo geometric information presents significant challenges in the development of patient-specific computational models. There is thus a need to determine the level of detail necessary for predictive MV models...
August 3, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28770032/effects-of-decreased-annular-height-and-annular-saddle-shaped-non-planarity-in-degenerative-severe-mitral-regurgitation-with-normal-left-ventricular-ejection-fraction-real-time-3d-transesophageal-echocardiography
#3
Eun Jeong Cho, Sung-Ji Park, Ga Yeon Lee, Eun Kyoung Kim, Sung-A Chang, Jin-Oh Choi, Sang-Chol Lee, Seung Woo Park, Pyo Won Park
BACKGROUND: The extent of mitral annular (MA) remodeling and dysfunction is correlated with the severity of mitral regurgitation (MR) as well as left atrial (LA) and left ventricular (LV) dilation. MA dysfunction may be a useful prognostic factor for operative timing and MR recurrence after successful mitral valve (MV) repair. The aim of this study was to evaluate additive prognostic factors of MA non-planarity using real-time 3D transesophageal echocardiography (RT3D-TEE) analysis in patients with chronic severe MR and preserved LV systolic function...
June 2017: Journal of Cardiovascular Ultrasound
https://www.readbyqxmd.com/read/28762165/the-mid-term-results-of-mitral-valve-repair-for-isolated-mitral-regurgitation-in-infancy-and-childhood
#4
Yi Shi, Haitao Xu, Jun Yan, Qiang Wang, Shoujun Li, Tong Yi, Yajuan Zhang, Wenchao Liu
The objective of this study was to assess the mid-term results of mitral valve (MV) repair in infancy and childhood with isolated mitral regurgitation (MR). From January 2005 to January 2016, 40 consecutive patients with isolated MR underwent MV repair in Fuwai Hospital, Beijing, China. Patients' clinical data were analyzed retrospectively. Mean age at operation was 13 ± 5 (6-24) months and 22 patients (55%) were younger than 1 year. Mean weight at operation was 8.5 ± 1.9 (4.2-13) kg and 34 patients (85%) were lighter than 10 kg...
July 31, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28740719/multimodality-imaging-assessment-of-mitral-valve-anatomy-in-planning-for-mitral-valve-repair-in-secondary-mitral-regurgitation
#5
REVIEW
Romain Capoulade, Nicolas Piriou, Jean-Michel Serfaty, Thierry Le Tourneau
Secondary mitral regurgitation (MR) is frequent valvular heart disease and conveys worse prognostic. Therapeutic surgical or percutaneous options are available in the context of severe symptomatic secondary MR, but the best approach to treat these patients remains unclear, given the lack of clear clinical evidence of benefit. A comprehensive evaluation of the mitral valve apparatus and the left ventricle (LV) has the ability to clearly define and characterize the disease, and thus determine the best option for the patient to improve its clinical outcomes, as well as quality of life and symptoms...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740714/aortic-valve-replacement-in-patients-with-a-left-ventricular-ejection-fraction-%C3%A2-35-performed-via-a-minimally-invasive-right-thoracotomy
#6
Orlando Santana, Steve Xydas, Roy F Williams, Angelo La Pietra, Maurice Mawad, Vicente Behrens, Esteban Escolar, Christos G Mihos
BACKGROUND: We evaluated the outcomes of patients with aortic valve pathology in the setting of a left ventricular ejection fraction ≤35% who underwent minimally invasive aortic valve replacement (AVR), with or without concomitant mitral valve (MV) surgery. METHODS: All minimally invasive AVR in patients with a left ventricular ejection fraction ≤35%, performed via a right thoracotomy for aortic stenosis or regurgitation between January 2009 and March 2013, were retrospectively evaluated...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740712/hybrid-approach-of-percutaneous-coronary-intervention-followed-by-minimally-invasive-mitral-valve-surgery-a-5-year-single-center-experience
#7
Orlando Santana, Steve Xydas, Roy F Williams, Maurice Mawad, Todd B Heimowitz, Andrés M Pineda, Howard S Goldman, Christos G Mihos
BACKGROUND: The current study evaluated the safety and feasibility of staged ("hybrid") percutaneous coronary intervention (PCI) followed by isolated minimally invasive mitral valve (MV) surgery [PCI + minimally invasive mitral valve surgery (MIMVS)], for patients with concomitant coronary artery and MV disease. METHODS: A total of 93 patients who underwent PCI + MIMVS for coronary artery and MV disease between February 2009 and April 2014 were retrospectively analyzed...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740711/mitral-valve-repair-and-subvalvular-intervention-for-secondary-mitral-regurgitation-a-systematic-review-and-meta-analysis-of-randomized-controlled-and-propensity-matched-studies
#8
Christos G Mihos, Steve Xydas, Evin Yucel, Romain Capoulade, Roy F Williams, Maurice Mawad, Guillermo Garcia, Orlando Santana
BACKGROUND: Combining a ring annuloplasty (Ring) with a mitral subvalvular intervention (Ring + subvalvular) in patients with secondary mitral regurgitation (MR) may improve mitral valve (MV) repair durability. However, the outcomes of this strategy compared with a Ring only, have not been clearly defined. METHODS: A systematic review and meta-analysis was performed utilizing randomized controlled and propensity matched studies which compared a Ring + subvalvular versus Ring MV repair for the treatment of secondary MR...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28728865/mass-spring-models-for-the-simulation-of-mitral-valve-function-looking-for-a-trade-off-between-reliability-and-time-efficiency
#9
O A Pappalardo, F Sturla, F Onorati, G Puppini, M Selmi, G B Luciani, G Faggian, A Redaelli, E Votta
Patient-specific finite element (FE) models can assess the impact of mitral valve (MV) repair on the complex MV anatomy and function. However, FE excessive time requirements hamper their use for surgical planning; mass-spring models (MSMs) represent a more approximate approach but can provide almost real-time simulations. On this basis, we implemented MSMs of three healthy MVs from cardiac magnetic resonance (cMR) imaging to simulate the systolic MV closure, including the in vivo papillary muscles and annular kinematics, and the anisotropic and non-linear mechanical response of MV tissues...
July 17, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28724839/effect-of-recurrent-mitral-regurgitation-after-mitral-valve-repair-in-patients-with-degenerative-mitral-regurgitation
#10
Jung-Hwan Kim, Seung Hyun Lee, Hyun-Chel Joo, Young-Nam Youn, Kyung-Jong Yoo, Byung-Chul Chang, Sak Lee
BACKGROUND: This study investigated the consequences of recurrent mitral regurgitation (MR) after mitral valve (MV) repair in patients with degenerative MR and risk factors for recurrence.Methods and Results:From January 1990 to December 2015, 792 patients underwent MV repair due to degenerative MR. Recurrent MR was defined as moderate-to-severe MR on follow-up echocardiography. Mean follow-up duration was 8.71±5.58 years. During the follow-up period, MR recurred in 133 (16.8%) patients, and the MR recurrence-free rate at 20 years was 77...
July 20, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28711779/hyperactive-foxo1-results-in-lack-of-tip-stalk-identity-and-deficient-microvascular-regeneration-during-kidney-injury
#11
Lan T H Dang, Takahide Aburatani, Graham A Marsh, Bryce G Johnson, Stella Alimperti, Christine J Yoon, Angela Huang, Suzanne Szak, Naoki Nakagawa, Ivan Gomez, Shuyu Ren, Sarah K Read, Chris Sparages, Alfred C Aplin, Roberto F Nicosia, Chris Chen, Giovanni Ligresti, Jeremy S Duffield
Loss of the microvascular (MV) network results in tissue ischemia, loss of tissue function, and is a hallmark of chronic diseases. The incorporation of a functional vascular network with that of the host remains a challenge to utilizing engineered tissues in clinically relevant therapies. We showed that vascular-bed-specific endothelial cells (ECs) exhibit differing angiogenic capacities, with kidney microvascular endothelial cells (MVECs) being the most deficient, and sought to explore the underlying mechanism...
July 7, 2017: Biomaterials
https://www.readbyqxmd.com/read/28697003/the-respect-rather-than-resect-principle-in-mitral-valve-repair-the-lateral-dislocation-of-the-p2-technique
#12
Marco Zanobini, Gabriella Ricciardi, Francesco Liborio Mammana, Samer Kassem, Paolo Poggio, Alessandro Di Minno, L Cavallotti, Matteo Saccocci
BACKGROUND: Leaflet resection represents the reference standard for surgical treatment of mitral valve (MV) regurgitation. New approaches recently proposed place emphasis on respecting, rather than resecting, the leaflet tissue to avoid the drawbacks of the 'resection' approach. OBJECTIVES: The lateral dislocation of mid portion of mitral posterior leaflet (P2) technique for MV repair is a nonresectional technique in which the prolapsed P2 segment is sutured to normal P1 segment...
September 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28683992/assessment-of-mitral-valve-repair-with-exercise-echocardiography-artificial-chordae-vs-leaflet-resection
#13
Sigurdur Ragnarsson, Johan Sjögren, Martin Stagmo, Per Wierup, Shahab Nozohoor
Mitral valve (MV) repair with artificial chordae (AC) or leaflet resection (LR) is associated with good hemodynamics at rest. The aim of this study was to compare these techniques in terms of exercise capacity and echocardiographic parameters of hemodynamics at rest and peak exercise. We conducted a study in 2015 of 56 patients, who had undergone surgery for degenerative posterior mitral leaflet prolapse between 2005 and 2014 using either AC (n = 24) or LR (n = 32). Clinical data were collected, exercise capacity was measured, and resting echocardiography and peak exercise echocardiography were performed...
April 2017: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28676926/the-infant-with-aortic-arch-hypoplasia-and-small-left-heart-structures-echocardiographic-indices-of-mitral-and-aortic-hypoplasia-predicting-successful-biventricular-repair
#14
Jennifer M Plymale, Peter C Frommelt, Melodee Nugent, Pippa Simpson, James S Tweddell, Amanda J Shillingford
In infants with aortic arch hypoplasia and small left-sided cardiac structures, successful biventricular repair is dependent on the adequacy of the left-sided structures. Defining accurate thresholds of echocardiographic indices predictive of successful biventricular repair is paramount to achieving optimal outcomes. We sought to identify pre-operative echocardiographic indices of left heart size that predict intervention-free survival in infants with small left heart structures undergoing primary aortic arch repair to establish biventricular circulation (BVC)...
August 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28655533/a-unique-hybrid-approach-to-complex-re-do-aortic-root-surgery
#15
Fiona Doig, Rishen Naidoo, Vinod Sharma, Peter Tesar
BACKGROUND: We present the case of a 23-year-old male with ventriculo-aortic dehiscence and a retrosternal false aneurysm communicating to the left ventricular outflow tract (LVOT) and ascending aorta. His history included aortic valve replacement (AVR) and mitral valve (MV) repair remotely, followed by two further operations for endocarditis and aortic root abscess. METHODS: The risk associated with the redo surgery required detailed planning and innovative techniques to allow it to be performed safely...
June 1, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28576476/mitral-valve-repair-in-dogs-using-an-eptfe-chordal-implantation-device-a-pilot-study
#16
M Borgarelli, O Lanz, N Pavlisko, J A Abbott, G Menciotti, M Aherne, S M Lahmers, K K Lahmers, J S Gammie
OBJECTIVE: Mitral valve (MV) regurgitation due to degenerative MV disease is the leading cause of cardiac death in dogs. We carried out preliminary experiments to determine the feasibility and short-term effects of beating-heart MV repair using an expanded polytetrafluorethylene (ePTFE) chordal implantation device (Harpoon TSD-5) in dogs. ANIMALS: This study involved six healthy purpose-bred Beagles (weight range 8.9-11.4 kg). MATERIAL AND METHODS: Following a mini-thoracotomy performed under general anesthesia, the TSD-5 was used to place 1 or 2 artificial ePTFE cords on the anterior MV leaflet or the posterior MV leaflet via a left-ventricular transapical approach...
May 31, 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/28566643/prolapse-volume-to-prolapse-height-ratio-for-differentiating-barlow-s-disease-from-fibroelastic-deficiency
#17
Nobuyuki Kagiyama, Misako Toki, Akihiro Hayashida, Minako Ohara, Atsushi Hirohata, Keizo Yamamoto, Toshinori Totsugawa, Taichi Sakaguchi, Kiyoshi Yoshida, Mitsuaki Isobe
BACKGROUND: As mitral valve (MV) repair for Barlow's disease remains surgically challenging, it is important to distinguish Barlow's disease from fibroelastic deficiency (FED) preoperatively. We hypothesized that the prolapse volume to prolapse height ratio (PV-PH ratio) may be useful to differentiate Barlow's disease and FED.Methods and Results:In 76 patients with MV prolapse who underwent presurgical transesophageal echocardiography, the 3D MV morphology was quantified: 19 patients were diagnosed with Barlow's disease and 57 with FED...
May 31, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28544831/aortic-root-surgery-in-marfan-syndrome-medium-term-outcome-in-a-single-center-experience
#18
Christine H Attenhofer Jost, Heidi M Connolly, Christopher G Scott, Naser M Ammash, Juan M Bowen, Hartzell V Schaff
BACKGROUND: The study aim was to analyze the authors' experience with aortic root surgery in Marfan syndrome (MFS), and to expand the surgical outcome data of patients meeting the Ghent criteria (Marfan registry). METHODS: Analyses were performed of data acquired from MFS patients (who met the Ghent criteria), including an aortic root surgery and Kaplan-Meier survival. RESULTS: Between April 2004 and February 2012, a total of 59 MFS patients (mean age at surgery 36 ± 13 years) underwent 67 operations for aortic root aneurysm (n = 52), aortic valve (AV) regurgitation (n = 15), acute aortic dissection (n = 2), and/or mitral valve (MV) regurgitation resulting from MV prolapse (n = 7)...
January 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28523174/rupture-of-gore-tex-neochordae-10-years-after-mitral-valve-repair
#19
Makoto Mori, Philip Y K Pang, Sabet W Hashim
The current non-resectional paradigm in mitral valve (MV) repair emphasizes the use of polytetrafluoroethylene (PTFE) for artificial chordal replacement. While excellent long-term durability of repair using PTFE neochordae has been established, there have been rare reports of neochordal rupture at various times after surgery. We report a case of artificial chordal rupture 10 years after anterior mitral leaflet repair, necessitating reoperation. This complication may have been precipitated by maldistributed intracardiac tensile forces as a consequence of a malpositioned annuloplasty band...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28521809/role-of-mitral-valve-repair-in-active-infective-endocarditis-long-term-results
#20
Carlo Rostagno, Enrico Carone, Pier Luigi Stefàno
BACKGROUND: Although mitral valve repair is at present the technique of choice in mitral regurgitation (MR) due to degenerative valve disease, long term results in patients with active mitral infective endocarditis (IE) are still under evaluation. METHODS: In the study were included 34 consecutive patients (22 males; mean age, 60 years; range 32-84 years) referred to our institution between January 1, 2005 to December 31, 2011 who were treated with valve repair for mitral valve (MV) active infective endocarditis...
May 18, 2017: Journal of Cardiothoracic Surgery
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