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https://www.readbyqxmd.com/read/28335495/brain-derived-neurotrophic-factor-loaded-ps80-pbca-nanocarrier-for-in-vitro-neural-differentiation-of-mouse-induced-pluripotent-stem-cells
#1
Chiu-Yen Chung, Martin Hsiu-Chu Lin, I-Neng Lee, Tsong-Hai Lee, Ming-Hsueh Lee, Jen-Tsung Yang
Brain derived neurotrophic factor (BDNF) can induce neural differentiation in stem cells and has the potential for repair of the nervous system. In this study, a polysorbate 80-coated polybutylcyanoacrylate nanocarrier (PS80 PBCA NC) was constructed to deliver plasmid DNAs (pDNAs) containing BDNF gene attached to a hypoxia-responsive element (HRE-cmvBDNF). The hypoxia-sensing mechanism of BDNF expression and inductiveness of the nano-formulation on mouse induced pluripotent stem cells (iPSCs) to differentiate into neurons following hypoxia was tested in vitro with immunofluorescent staining and Western blotting...
March 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28297585/electromechanical-conditioning-of-adult-progenitor-cells-improves-recovery-of-cardiac-function-after-myocardial-infarction
#2
Aida Llucià-Valldeperas, Carolina Soler-Botija, Carolina Gálvez-Montón, Santiago Roura, Cristina Prat-Vidal, Isaac Perea-Gil, Benjamin Sanchez, Ramon Bragos, Gordana Vunjak-Novakovic, Antoni Bayes-Genis
Cardiac cells are subjected to mechanical and electrical forces, which regulate gene expression and cellular function. Therefore, in vitro electromechanical stimuli could benefit further integration of therapeutic cells into the myocardium. Our goals were (a) to study the viability of a tissue-engineered construct with cardiac adipose tissue-derived progenitor cells (cardiac ATDPCs) and (b) to examine the effect of electromechanically stimulated cardiac ATDPCs within a myocardial infarction (MI) model in mice for the first time...
March 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28286089/conventional-surgery-for-early-and-late-symptomatic-mitral-valve-stenosis-after-mitraclip-%C3%A2-intervention-an-institutional-experience-with-four-consecutive-patients
#3
Anthony Alozie, Liliya Paranskaya, Bernd Westphal, Alexander Kaminski, Gustav Steinhoff, Mohammad Sherif, Hüseyin Ince, Alper Öner
BACKGROUND: Surgical mitral valve repair is the gold standard for treatment of mitral regurgitation. Recently, the transcatheter treatment of mitral regurgitation with the MitraClip(®) device (Abbot Vascular Structural Heart, Menlo Park, CA) has demonstrated promising results in treating patients not amenable for surgical correction of mitral valve regurgitation. Most patients reported in the literature requiring surgical bailout after MitraClip treatment presented with residual or recurrent mitral valve regurgitation...
February 17, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28274519/regional-heterogeneity-in-the-mitral-valve%C3%A2-apparatus-in-patients-with-ischemic%C3%A2-mitral-regurgitation
#4
Feroze Mahmood, Ziyad O Knio, Lu Yeh, Rabia Amir, Robina Matyal, Azad Mashari, Robert C Gorman, Joseph H Gorman, Kamal R Khabbaz
BACKGROUND: Apical displacement of the coaptation point of the mitral valve (MV) in response to ischemic mitral regurgitation (IMR) represents remodeling of the MV apparatus. Whereas it implies chronicity, it lacks specificity in discriminating normal from a significantly remodeled MV apparatus. Regional aspects of MV remodeling have shown superior value over global remodeling in predicting recurrence after MV repair for IMR. Quite possibly, presence of specific regional changes in MV geometry that are unique to chronic IMR patients could also be used to diagnose the presence and track progression of remodeling...
March 5, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28262288/tricuspid-regurgitation-is-uncommon-after-mitral-valve-repair-for-degenerative-diseases
#5
Tirone E David, Carolyn M David, Chun-Po S Fan, Cedric Manlhiot
OBJECTIVE: To determine the incidence and effects of tricuspid regurgitation (TR) after surgery for mitral valve (MV) repair for mitral regurgitation (MR) due to degenerative disease. PATIENTS AND METHODS: We examined 1171 patients who had MV repair and were followed prospectively with periodical clinical and echocardiographic assessments during a mean of 9.1 ± 5.3 years. Patients' mean age was 58.2 ± 12.7 years, and 70.5% were men. Preoperatively, 44.6% were in functional classes III and IV, 20...
February 7, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28203538/robotic-mitral-valve-repair-for-degenerative-posterior-leaflet-prolapse
#6
Hoda Javadikasgari, Rakesh M Suri, Bassman Tappuni, Ashley M Lowry, Tomislav Mihaljevic, Stephanie Mick, A Marc Gillinov
BACKGROUND: Robotic mitral valve (MV) repair is the least invasive surgical approach to the MV and provides unparalleled access to the valve. We sought to assess technical aspects and clinical outcomes of robotic MV repair for isolated posterior leaflet prolapse by examining the first 623 such cases performed in a tertiary care center. METHODS: We reviewed the first 623 patients (mean age 56±9.7 years) with isolated posterior leaflet prolapse who underwent robotic primary MV repair from 01/2006 to 11/2013...
January 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28203536/clinical-outcomes-of-robotic-mitral-valve-repair-a-single-center-experience-in-korea
#7
Ho Jin Kim, Joon Bum Kim, Sung-Ho Jung, Jae Won Lee
BACKGROUND: Since the inception of robotic mitral valve repair (MV) in 2007 at our institution, it has become an acceptable surgical option with proven efficacy and safety. The objective of this study is to analyze the early and long-term clinical outcomes of patients undergoing robotic MV repair. METHODS: A total of 310 patients (aged 48.4±13.7 years, 201 males) undergoing robotic MV repair using the da Vinci system (Intuitive Surgical, Inc., Sunnyvale, CA) between August 2007 and December 2015 in our institution were evaluated...
January 2017: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28186501/intrinsic-repair-protects-cells-from-pore-forming-toxins-by-microvesicle-shedding
#8
Matthew Romero, Michelle Keyel, Guilan Shi, Pushpak Bhattacharjee, Robyn Roth, John E Heuser, Peter A Keyel
Pore-forming toxins (PFTs) are used by both the immune system and by pathogens to disrupt cell membranes. Cells attempt to repair this disruption in various ways, but the exact mechanism(s) that cells use are not fully understood, nor agreed upon. Current models for membrane repair include (1) patch formation (e.g., fusion of internal vesicles with plasma membrane defects), (2) endocytosis of the pores, and (3) shedding of the pores by blebbing from the cell membrane. In this study, we sought to determine the specific mechanism(s) that cells use to resist three different cholesterol-dependent PFTs: Streptolysin O, Perfringolysin O, and Intermedilysin...
February 10, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28130803/mitral-annular-motion-in-patients-after-transcatheter-mitraclip-and-mitral-valve-surgery
#9
Kentaro Toyama, Florian Rader, Kengo Ayabe, Saibal Kar, Alfredo Trento, Toshihiko Nishioka, Michele A De Robertis, Robert J Siegel
BACKGROUND: Longitudinal motion of the mitral annulus is an index that reflects left ventricular (LV) function. The aim of this study was to evaluate and compare the effects of transcatheter mitral valve (MV) repair and open heart surgery for mitral regurgitation (MR) on mitral annular motion (MAM). METHODS: We retrospectively analyzed in total 115 patients who underwent isolated transcatheter MV repair using MitraClip (n=50) or surgical MV interventions (n=65, 50 repairs and 15 replacements) for MR...
March 2017: Echocardiography
https://www.readbyqxmd.com/read/28101839/surgical-treatment-of-ischemic-mitral-regurgitation-valve-repair-versus-replacement
#10
REVIEW
Abhishek Sharma, Sahil Agrawal, Sunny Goel, Jeffrey S Borer
PURPOSE OF REVIEW: Ischemic mitral regurgitation (MR), which occurs in about 20-30% patients with a prior myocardial infarction, is associated with worsening heart failure and an increase in cardiovascular mortality. It should be treated surgically if certain hemodynamic severity criteria are met and in patients who continue to experience symptoms of heart failure despite optimal medical therapy. However, current guidelines do not suggest which of the available approaches to mitral valve surgery-mitral valve (MV) repair or replacement (MVR) is superior for this indication...
January 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28100645/lipoxin-a4-stimulates-endothelial-mir-126-5p-expression-and-its-transfer-via-microvesicles
#11
Marilina Codagnone, Antonio Recchiuti, Paola Lanuti, Anna Maria Pierdomenico, Eleonora Cianci, Sara Patruno, Veronica Cecilia Mari, Felice Simiele, Pamela Di Tomo, Assunta Pandolfi, Mario Romano
The proresolution lipid mediator lipoxin (LX)A4 bestows protective bioactions on endothelial cells. We examined the impact of LXA4 on transcellular endothelial signaling via microRNA (miR)-containing microvesicles. We report LXA4 inhibition of MV release by TNF-α-treated HUVECs, associated with the down-regulation of 18 miR in endothelial microvesicles (EMVs) and the up-regulation of miR-126-5p, both in HUVECs and in EMVs. LXA4 up-regulated miR-126-5p by ∼5-fold in HUVECs and promoted a release of microvesicles (LXA4-EMVs) that enhanced miR-126-5p by ∼7-fold in recipient HUVECs...
January 18, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28072764/antitumour-activity-of-trabectedin-in-myelodysplastic-myeloproliferative-neoplasms
#12
Michela Romano, Matteo Giovanni Della Porta, Anna Gallì, Nicolò Panini, Simonetta Andrea Licandro, Ezia Bello, Ilaria Craparotta, Vittorio Rosti, Elisa Bonetti, Richard Tancredi, Marianna Rossi, Laura Mannarino, Sergio Marchini, Luca Porcu, Carlos M Galmarini, Alberto Zambelli, Marco Zecca, Franco Locatelli, Mario Cazzola, Andrea Biondi, Alessandro Rambaldi, Paola Allavena, Eugenio Erba, Maurizio D'Incalci
BACKGROUND: Juvenile myelomonocytic leukaemia (JMML) and chronic myelomonocytic leukaemia (CMML) are myelodysplastic myeloproliferative (MDS/MPN) neoplasms with unfavourable prognosis and without effective chemotherapy treatment. Trabectedin is a DNA minor groove binder acting as a modulator of transcription and interfering with DNA repair mechanisms; it causes selective depletion of cells of the myelomonocytic lineage. We hypothesised that trabectedin might have an antitumour effect on MDS/MPN...
January 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28070866/finite-element-analysis-of-patient-specific-mitral-valve-with-mitral-regurgitation
#13
Thuy Pham, Fanwei Kong, Caitlin Martin, Qian Wang, Charles Primiano, Raymond McKay, John Elefteriades, Wei Sun
Functional mitral regurgitation (FMR) is a significant complication of left ventricular dysfunction and strongly associated with a poor prognosis. In this study, we developed a patient-specific finite element (FE) model of the mitral apparatus in a FMR patient which included: both leaflets with thickness, annulus, chordae tendineae, and chordae insertions on the leaflets and origins on the papillary muscles. The FE model incorporated human age- and gender-matched anisotropic hyperelastic material properties, and MV closure at systole was simulated...
March 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28047372/su-f-t-128-dose-volume-constraints-for-particle-therapy-treatment-planning
#14
R Stewart, W Smith, K Hendrickson, J Meyer, N Cao, E Lee, O Gopan, G Sandison, U Parvathaneni, G Laramore
PURPOSE: Determine equivalent Organ at Risk (OAR) tolerance dose (TD) constraints for MV x-rays and particle therapy. METHODS: Equivalent TD estimates for MV x-rays are determined from an isoeffect, regression-analysis of published and in-house constraints for various fractionation schedules (n fractions). The analysis yields an estimate of (α/β) for an OAR. To determine equivalent particle therapy constraints, the MV x-ray TD(n) values are divided by the RBE for DSB induction (RBEDSB ) or cell survival (RBES )...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046333/su-f-t-681-does-the-biophysical-modeling-for-immunological-aspects-in-radiotherapy-precisely-predict-tumor-and-normal-tissue-responses
#15
M Oita, K Nakata, M Sasaki, M Tominaga, H Aoyama, H Honda, Y Uto
PURPOSE: Recent advances in immunotherapy make possible to combine with radiotherapy. The aim of this study was to assess the TCP/NTCP model with immunological aspects including stochastic distribution as intercellular uncertainties. METHODS: In the clinical treatment planning system (Eclipse ver.11.0, Varian medical systems, US), biological parameters such as α/β, D50, γ, n, m, TD50 including repair parameters (bi-exponential repair) can be set as any given values to calculate the TCP/NTCP...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044989/surgical-mitral-valve-replacement-with-melody-valve-in-infants-and-children-the-italian-experience
#16
Alessandro Frigiola, Francesca Romana Pluchinotta, Antonio Saracino, Alessandro Giamberti, Carmelo Arcidiacono, Luciane Piazza, Matteo Reali, Gianfranco Butera, Alessandro Varrica, Mario Carminati
AIMS: Paediatric patients with mitral valve (MV) disease have limited options for prosthetic MV replacement. Based on a long experience with the stented bovine jugular vein graft (Melody Valve) in the right ventricular outflow tract, we tested the use of the Melody Valve as a surgical implant in the mitral position in patients with congenital mitral disease. METHODS AND RESULTS: Eight patients, age 3 months to 6.2 years, with congenital MV dysplasia had undergone Melody valve implantation in mitral position between March 2014 and October 2015...
January 3, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28043459/repair-of-parachute-and-hammock-valve-in-infants-and-children-early-and-late-outcomes
#17
Eva Maria Delmo Walter, Mariano Javier, Roland Hetzer
Parachute and hammock valves in children remain one of the most challenging congenital malformations to correct. We report our institutional experience with valve-preserving repair techniques and the early and late surgical outcomes in parachute and hammock valves in infants and children. From January 1990-June 2014, 20 infants and children with parachute (n = 12, median age = 2.5 years, range: 2 months-13 years) and hammock (n = 8, median age = 7 months, range: 1 month-14.9 years) valves underwent mitral valve (MV) repair...
July 2016: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28041699/impact-of-interventional-edge-to-edge-repair-on-mitral-valve-geometry
#18
Robert Schueler, Sarah Kaplan, Charlotte Melzer, Can Öztürk, Marcel Weber, Jan-Malte Sinning, Armin Welz, Nikos Werner, Georg Nickenig, Christoph Hammerstingl
BACKGROUND/OBJECTIVES: The acute and long-term effects of interventional edge-to-edge repair on the mitral valve (MV) geometry are unclear. We sought to assess MV-annular geometry and the association of changes in MV-diameters with functional response one year after MitraClip implantation. METHODS: Consecutive patients (n=84; age 81.2±8.3years, logistic EuroSCORE 21.7±17.9%) with symptomatic moderate-to-severe mitral regurgitation (MR) underwent MitraClip-procedure...
March 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28039280/selection-of-critical-isthmus-in-scar-related-atrial-tachycardia-using-a-new-automated-ultrahigh-resolution-mapping-system
#19
Decebal Gabriel Laţcu, Sok-Sithikun Bun, Frédéric Viera, Tahar Delassi, Mohammed El Jamili, Alaa Al Amoura, Nadir Saoudi
BACKGROUND: Accurate activation mapping of reentrant scar-related atrial tachycardias (AT) allows efficient radiofrequency ablation by targeting the critical isthmus (CI). We aimed to assess the electrophysiological properties of CI channels during mapping with the IntellaMap Orion basket and the Rhythmia system. METHODS AND RESULTS: We prospectively studied 33 AT (post- atrial fibrillation ablation or surgical mitral valve repair). The noise of bipolar electrogram (EGM) was systematically measured at 10 prespecified sites, as well as on a standard catheter and on the surface ECG...
January 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27995395/mitral-valve-chordae-tendineae-topological-and-geometrical-characterization
#20
Amir H Khalighi, Andrew Drach, Charles H Bloodworth, Eric L Pierce, Ajit P Yoganathan, Robert C Gorman, Joseph H Gorman, Michael S Sacks
Mitral valve (MV) closure depends upon the proper function of each component of the valve apparatus, which includes the annulus, leaflets, and chordae tendineae (CT). Geometry plays a major role in MV mechanics and thus highly impacts the accuracy of computational models simulating MV function and repair. While the physiological geometry of the leaflets and annulus have been previously investigated, little effort has been made to quantitatively and objectively describe CT geometry. The CT constitute a fibrous tendon-like structure projecting from the papillary muscles (PMs) to the leaflets, thereby evenly distributing the loads placed on the MV during closure...
February 2017: Annals of Biomedical Engineering
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