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https://www.readbyqxmd.com/read/29045843/high-throughput-functional-genetic-and-compound-screens-identify-targets-for-senescence-induction-in-cancer
#1
Liqin Wang, Rodrigo Leite de Oliveira, Cun Wang, João M Fernandes Neto, Sara Mainardi, Bastiaan Evers, Cor Lieftink, Ben Morris, Fleur Jochems, Lisa Willemsen, Roderick L Beijersbergen, René Bernards
Senescence is a proliferation arrest that can result from a variety of stresses. Cancer cells can also undergo senescence, but the stresses that provoke cancer cells to undergo senescence are unclear. Here, we use both functional genetic and compound screens in cancer cells harboring a reporter that is activated during senescence to find targets that induce senescence. We show that suppression of the SWI/SNF component SMARCB1 induces senescence in melanoma through strong activation of the MAP kinase pathway...
October 17, 2017: Cell Reports
https://www.readbyqxmd.com/read/29045247/factors-associated-with-higher-caregiver-burden-among-family-caregivers-of-elderly-cancer-patients-a-systematic-review
#2
Lixia Ge, Siti Zubaidah Mordiffi
BACKGROUND: Caring for elderly cancer patients may cause multidimensional burden on family caregivers. Recognition of factors associated with caregiver burden is important for providing proactive support to caregivers at risk. OBJECTIVE: The aim of this study was to identify factors associated with high caregiver burden among family caregivers of elderly cancer patients. METHODS: A systematic search of 7 electronic databases was conducted from database inception to October 2014...
November 2017: Cancer Nursing
https://www.readbyqxmd.com/read/29044929/anticancer-activity-of-vmct1-analogs-against-mcf-7-cells
#3
Cibele Nicolaski Pedron, Gislaine Patricia Andrade, Roseli Hiromi Sato, Marcelo Der Torossian Torres, Giselle Cerchiaro, Anderson Orzari Ribeiro, Vani Xavier Oliveira Junior
Antimicrobial peptides are considered promising drug candidates due to their broad range of activity. VmCT1 (Phe-Leu-Gly-Ala-Leu-Trp-Asn-Val-Ala-Lys-Ser-Val-Phe-NH2 ) is an α-helical antimicrobial peptide that was obtained from the Vaejovis mexicanus smithi scorpion venom. Some of its analogs showed to be as antimicrobial as the wild type and they were designed for understanding the influence of physiochemical parameters on antimicrobial and hemolytic activity. Some cationic antimicrobial peptides exhibit anticancer activity so VmCT1 analogs were tested in order to verify the anticancer activity of this family of peptides...
October 17, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29043283/barriers-to-pap-smear-test-for-the-second-time-in-women-referring-to-health-care-centers-in-the-south-of-tehran-a-qualitative-approach
#4
Laleh Hassani, Tahereh Dehdari, Ebrahim Hajizadeh, Davoud Shojaeizadeh, Mehrandokht Abedini, Saharnaz Nedjat
BACKGROUND: Cervical cancer is a preventable disease with a regular screening program. Many studies have reported a large number of barriers that women had for the first time, but this study decided to find other barriers for the second time pap smear. METHODS: In this qualitative research, data were gathered through in-depth interviews and expressed through conventional content analysis in the form of constant comparison. The participants were 15 women with family profile at 30 health care centers who lived in the south of Tehran and had done Pap smear for one time but didn't do it for the second time...
October 2017: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/29043277/the-effect-of-telephone-counseling-and-education-on-breast-cancer-screening-in-family-caregivers-of-breast-cancer-patients
#5
Khadijeh Nasiriani, Monireh Motevasselian, Farahnaz Farnia, Seyed Mostafa Shiryazdi, Mahsa Khodayarian
BACKGROUND: Breast cancer is the most common form of malignancy among females. Family history is a key risk factor for breast cancer. Breast cancer screening practices are vital in patients with family history of breast cancer. Telephone counseling and education may be appropriate for improved breast cancer screening. This study was done to determine family caregiver patients' knowledge of risk factors for breast cancer and practice of breast cancer screening and also to assess the effect of telephone counseling and education on mammography screening...
October 2017: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/29043114/expression-of-stk11-gene-and-its-promoter-activity-in-mcf-control-and-cancer-cells
#6
Asma Alkaf, Abdulaziz Al-Jafari, Tanveer A Wani, Somaya Alqattan, Seema Zargar
Serine/threonine kinase gene (STK11) is identified as tumor suppressor gene whose mutation can lead to Peutz-Jeghers syndrome (PJS). STK11 is emerging as a multifunctional protein, it activates 14 different AMP-activated protein kinase (AMPK) family members, important in the regulation of cell polarity, cell cycle arrest, energy and hemostasis. Present study was designed to evaluate STK11 mRNA expression in MCF-7 cancer and MCF-10 normal breast cells lines. mRNA expression was studied by real-time PCR. Further, human STK11 promoter construct was fused to a luciferase reporter and transfected into both MCF-7 and MCF-10 cells to identify the promoter activity in these cells...
December 2017: 3 Biotech
https://www.readbyqxmd.com/read/29042999/pien-tze-huang-inhibits-the-proliferation-of-colorectal-cancer-cells-by-increasing-the-expression-of-mir-34c-5p
#7
Yun Wan, Aling Shen, Fei Qi, Jianfeng Chu, Qiaoyan Cai, Thomas Joseph Sferra, Jun Peng, Youqin Chen
MicroRNAs (miRNAs) are small, short endogenous non-coding RNA that act as oncogenes or tumor suppressors, and serve an important role in various human malignant cancers, including colorectal cancer (CRC). Evidence has indicated that miRNAs regulate the expression of various genes associated with human cancer, in particular the miR-34 family. A well-known traditional Chinese formula, Pien Tze Huang (PZH), has a significant clinical effect on CRC. Previous studies have demonstrated that PZH inhibits CRC growth in vitro and in vivo via multiple mechanisms, including the induction of apoptosis, inhibition of cell proliferation and tumor angiogenesis...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042969/silencing-of-tctn1-inhibits-proliferation-induces-cell-cycle-arrest-and-apoptosis-in-human-thyroid-cancer
#8
Peipei Xu, Xiaotian Xia, Zhili Yang, Yuan Tian, Jianzhong Di, Minggao Guo
Tectonic family member 1 (TCTN1) is one of the tectonic family members, and a regulator of the hedgehog signaling pathway, which has been studied in various cancer types, including prostate and pancreatic cancer. However, its function in thyroid cancer has not been well documented. Therefore, the present study investigated the function of TCTN1 in thyroid cancer using a loss-of-function assay. Lentivirus-mediated RNA interference was applied to downregulate TCTN1 in the thyroid cancer cell lines, CAL62 and 8305C...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042777/self-rated-cognitive-functions-following-chemotherapy-in-patients-with-breast-cancer-a-6-month-prospective-study
#9
Ryosuke Kitahata, Shinichiro Nakajima, Hiroyuki Uchida, Tetsu Hayashida, Maiko Takahashi, Shintaro Nio, Jinichi Hirano, Maki Nagaoka, Takefumi Suzuki, Hiromitsu Jinno, Yuko Kitagawa, Masaru Mimura
PURPOSE: The purpose of the study was to evaluate subjective (self-rated), family-rated, and objective (researcher-rated) cognitive functions in patients with breast cancer after chemotherapy. METHOD: We conducted a prospective study to trace self-rated cognitive functions in 30 patients with breast cancer at the completion of chemotherapy (T0) and 6 months later (T1). Subjective cognitive functions were assessed with Cognitive Failures Questionnaire (CFQ), Dysexecutive Questionnaire (DEX-S), and Everyday Memory Checklist (EMC-S) for attention, executive function, and episodic memory, respectively...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29042578/%C3%AE-defensin-1-expression-in-hcv-infected-liver-liver-cancer-an-important-role-in-protecting-hcv-progression-and-liver-cancer-development
#10
Yue-Ming Ling, Jin-Yu Chen, Libin Guo, Chen-Yi Wang, Wen-Ting Tan, Qing Wen, Shu-Dong Zhang, Guo-Hong Deng, Yao Lin, Hang Fai Kwok
β-defensin family plays a role in host defense against viral infection, however its role in HCV infection is still unknown. In this study, we demonstrated that β-defensin 1 was significantly reduced in HCV-infected liver specimens. Treatment with interferon and ribavirin upregulated β-defensin-1, but not other β-defensin tested, with the extent and duration of upregulation associated with treatment response. We investigated β-defensin family expression in liver cancer in publicly available datasets and found that among all the β-defensins tested, only β-defensin 1 was significantly downregulated, suggesting β-defensin 1 plays a crucial role in liver cancer development...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042285/regulating-the-regulators-epigenetic-transcriptional-and-post-translational-regulation-of-rgs-proteins
#11
REVIEW
Mohammed Alqinyah, Shelley B Hooks
Regulators of G protein signaling (RGS) are a family of proteins classically known to accelerate the intrinsic GTPase activity of G proteins, which results in accelerated inactivation of heterotrimeric G proteins and inhibition of G protein coupled receptor signaling. RGS proteins play major roles in essential cellular processes, and dysregulation of RGS protein expression is implicated in multiple diseases, including cancer, cardiovascular and neurodegenerative diseases. The expression of RGS proteins is highly dynamic and is regulated by epigenetic, transcriptional and post-translational mechanisms...
October 14, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/29042215/a-novel-stilbene-like-compound-that-inhibits-melanoma-growth-by-regulating-melanocyte-differentiation-and-proliferation
#12
Noah A Stueven, Nicholas M Schlaeger, Aaron P Monte, Sheng-Ping L Hwang, Cheng-Chen Huang
Melanoma is the most aggressive form of skin cancer. Current challenges to melanoma therapy include the adverse effects from immunobiologics, resistance to drugs targeting the MAPK pathway, intricate interaction of many signal pathways, and cancer heterogeneity. Thus combinational therapy with drugs targeting multiple signaling pathways becomes a new promising therapy. Here, we report a family of stilbene-like compounds called A11 that can inhibit melanoma growth in both melanoma-forming zebrafish embryos and mouse melanoma cells...
October 14, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29042085/advances-in-the-management-of-her2-positive-early-breast-cancer
#13
REVIEW
José Baselga, Robert E Coleman, Javier Cortés, Wolfgang Janni
While trastuzumab is firmly established as the cornerstone of therapy for both early and advanced breast cancer expressing human epidermal growth factor receptor 2 (HER2), many patients either do not respond to trastuzumab treatment or progress following therapy. Improved understanding of breast cancer biology, particularly the complex signaling interactions managed by the HER family of receptors, have resulted in development of several novel HER2-directed therapies and combinations. This article will review the novel approaches to HER2 targeting that have been developed in recent years, with particular focus on results from these approaches in early breast cancer, and will discuss strategies to improve the tolerability of HER2-directed therapies, including prevention of cardiac toxicity and diarrhea...
October 4, 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29040754/development-of-unique-cytotoxic-chimeric-antigen-receptors-based-on-human-scfv-targeting-b7h6
#14
Casey K Hua, Albert T Gacerez, Charles L Sentman, Margaret E Ackerman
As a stress-inducible natural killer (NK) cell ligand, B7H6 plays a role in innate tumor immunosurveillance and is a fairly tumor selective marker expressed on a variety of solid and hematologic cancer cells. Here, we describe the isolation and characterization of a new family of single chain fragment variable (scFv) molecules targeting the human B7H6 ligand. Through directed evolution of a yeast surface displayed non-immune human-derived scFv library, eight candidates comprising a single family of clones differing by up to four amino acid mutations and exhibiting nM avidities for soluble B7H6-Ig were isolated...
October 11, 2017: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/29040037/influence-of-risk-category-and-screening-round-on-the-performance-of-an-mr-imaging-and-mammography-screening-program-in-carriers-of-the-brca-mutation-and-other-women-at-increased-risk
#15
Suzan Vreemann, Albert Gubern-Mérida, Margrethe S Schlooz-Vries, Peter Bult, Carla H van Gils, Nicoline Hoogerbrugge, Nico Karssemeijer, Ritse M Mann
Purpose To evaluate the real-life performance of a breast cancer screening program for women with different categories of increased breast cancer risk with multiple follow-up rounds in an academic hospital with a large screening population. Materials and Methods Screening examinations (magnetic resonance [MR] imaging and mammography) for women at increased breast cancer risk (January 1, 2003, to January 1, 2014) were evaluated. Risk category, age, recall for workup of screening-detected abnormalities, biopsy, and histopathologic diagnosis were recorded...
October 16, 2017: Radiology
https://www.readbyqxmd.com/read/29039788/impact-of-natural-compounds-on-dna-methylation-levels-of-the-tumor-suppressor-gene-rassf1a-in-cancer
#16
REVIEW
Reinhard H Dammann, Antje M Richter, Adriana P Jiménez, Michelle Woods, Miriam Küster, Chamindri Witharana
Epigenetic inactivation of tumor suppressor genes (TSG) is a fundamental event in the pathogenesis of human cancer. This silencing is accomplished by aberrant chromatin modifications including DNA hypermethylation of the gene promoter. One of the most frequently hypermethylated TSG in human cancer is the Ras Association Domain Family 1A (RASSF1A) gene. Aberrant methylation of RASSF1A has been reported in melanoma, sarcoma and carcinoma of different tissues. RASSF1A hypermethylation has been correlated with tumor progression and poor prognosis...
October 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29039611/altered-expression-of-different-galnac%C3%A2-transferases-is-associated-with-disease-progression-and-poor-prognosis-in-women-with-high-grade-serous-ovarian-cancer
#17
Razan Sheta, Magdalena Bachvarova, Marie Plante, Jean Gregoire, Marie-Claude Renaud, Alexandra Sebastianelli, Ion Popa, Dimcho Bachvarov
Protein glycosylation perturbations are implicated in a variety of diseases, including cancer. Aberrant glycosylation in cancer is frequently attributed to altered expression of polypeptide GalNAc transferases (GalNAc‑Ts) - enzymes initiating mucin-type O-glycosylation. A previous study from our group demonstrated that one member of this family (GALNT3) is overexpressed in epithelial ovarian cancer (EOC), and GALNT3 expression correlated with shorter progression-free survival (PFS) in EOC patients with advanced disease...
October 9, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29039608/livin-promotes-the-progression-and-metastasis-of-breast-cancer-through-the-regulation-of-epithelial%C3%A2-mesenchymal-transition-via-the-p38-gsk3%C3%AE-pathway
#18
Yanchun Han, Li Zhang, Wei Wang, Jia Li, Min Song
Epithelial-mesenchymal transition (EMT) plays a pivotal role in the invasion and metastasis of breast cancer. Livin is a recently identified member of the inhibitors of the apoptosis protein family, which has been revealed to facilitate the progression of several types of cancer. However, the role of Livin in EMT and metastasis of breast cancer and its underlying mechanisms are not fully elucidated. In the present study, the levels of Livin mRNA and protein expression were found to be elevated in breast cancer tissues and cell lines...
October 10, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29039601/vasohibin2-promotes-adriamycin-resistance-of-breast-cancer-cells-through-regulating-abcg2-via-akt-signaling-pathway
#19
Deliang Ma, Liang Wu, Shuangjie Li, Zhigang Sun, Kai Wang
As a well‑known angiogenic factor in different histology and pathological conditions, the pro‑progressive role of vasohibin2 (VASH2) has been reported in various types of tumors. However, its role in drug resistance of breast cancer has not been reported so far. The present study demonstrated that MCF‑7 cells with increased expression of VASH2 demonstrate stronger adriamycin (ADM) resistance compared with MDA‑MB‑231 cells with decreased expression of VASH2. Overexpression of VASH2 in MDA‑MB‑231 cells increased ADM resistance and silencing VASH2 in MCF‑7 cells inhibited ADM resistance...
October 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039544/formyl-peptide-receptor%C3%A2-2-expression-predicts-poor-prognosis-and-promotes-invasion-and-metastasis-in-epithelial-ovarian-cancer
#20
Xiaohui Xie, Mengyuan Yang, Yiling Ding, Ling Yu, Jianlin Chen
Formyl peptide receptor 2 (FPR2) has been identified as a member of the G protein-coupled chemoattractant receptor (GPCR) family and has been implicated as playing a role in both inflammation and cancer development. Epithelial ovarian cancer (EOC) has been suggested to be correlated with both infectious and non-infectious inflammation. To date, the role of FPR2 in EOC remains poorly understood and controversial. In the present study, we aimed to investigate the potential of FPR2 in regulating EOC. We performed immunohistochemistry and RT-qPCR to analyzed expression of FPR2 in EOC tissues and the correlation between FPR2 and EOC clinicopathological characteristics as well as prognosis were also analyzed...
October 13, 2017: Oncology Reports
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