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https://www.readbyqxmd.com/read/29935265/li-fraumeni-syndrome-related-malignancies-involving-the-genitourinary-tract-review-of-a-single-institution-experience
#1
Katie S Murray, Massimiliano Spaliviero, Emily S Tonorezos, Mario E Lacouture, William D Tap, Kevin C Oeffinger, Hebert Alberto Vargas, James A Eastham
OBJECTIVES: To report a case of pelvic angiosarcoma in a 27-year-old man with Li-Fraumeni Syndrome (LFS) and evaluate the presentation and timeline of genitourinary (GU) tract involvement in LFS patients. METHODS: We retrospectively identified 39 LFS patients treated at our institution between 2000 and 2014; 7 (18%) had experienced a GU malignancy or an LFS-related malignancy involving the GU tract. Clinical characteristics, including dates of onset of first GU tract malignancies; pathologic findings; multimodal management; and familial history of LFS were reviewed...
June 20, 2018: Urology
https://www.readbyqxmd.com/read/29935031/pkg-ii-inhibits-pdgf-bb-triggered-biological-activities-by-phosphorylating-pdgfr%C3%AE-in-gastric-cancer-cells
#2
Ying Wang, Kwaku Appiah-Kubi, Ting Lan, Min Wu, Ji Pang, Hai Qian, Yan Tao, Lu Jiang, Yan Wu, Yongchang Chen
Previous studies revealed that type II Cgmp-dependent protein kinase G (PKG II) could inhibit the activation of epidermal growth factor receptor (EGFR) which is a widely investigated RTK. PDGFR belongs to family of receptor tyrosine kinases (RTKs) too. However, the effect of PKG II on PDGFR activation is not clear yet. This study investigated potential regulatory effect of PKG II on activation of PDGFRβ and the downstream signaling transductions in gastric cancer. The results from CCK8 assay and Transwell assay indicated that PDGF-BB induced cell proliferation and migration...
June 23, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29934866/backbone-assignment-of-the-apo-form-of-the-human-c-terminal-domain-of-udp-glucuronosyltransferase-1a-ugt1a
#3
Michael J Osborne, Luciana Coutinho de Oliveira, Laurent Volpon, Katherine L B Borden
A major component of phase II drug metabolism is the covalent addition of glucuronic acid to metabolites and xenobiotics. This activity is carried out by UDP-glucuronosyltransferases (UGT) which bind the UDP-glucuronic acid donor and catalyze the covalent addition of glucuronic acid sugar moieties onto a wide variety of substrates. UGTs play important roles in drug detoxification and were recently shown to act in an inducible form of multi-drug resistance in cancer patients. Despite their biological importance, structural understanding of these enzymes is limited...
June 22, 2018: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/29934670/the-bet-inhibitor-pfi-1-diminishes-ar-ar-v7-signaling-in-prostate-cancer-cells
#4
Marie C Hupe, M Raschid Hoda, Friedemann Zengerling, Sven Perner, Axel S Merseburger, Marcus V Cronauer
OBJECTIVE: The bromodomain and extra-terminal (BET) family of proteins provides a scaffolding platform for the recruitment and tethering of transcription factors to acetylated chromatin, thereby modulating gene expression. In this study, we evaluated the efficacy of the BET-inhibitor PFI-1 to diminish AR/AR-V7 signaling and proliferation in castration-resistant prostate cancer cells. METHODS: Prostate-specific antigen and androgen receptor (AR) protein were quantified by means of two commercial ELISAs...
June 22, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29934528/gramd1b-regulates-cell-migration-in-breast-cancer-cells-through-jak-stat-and-akt-signaling
#5
Puja Khanna, Joan Shuying Lee, Amornpun Sereemaspun, Haeryun Lee, Gyeong Hun Baeg
Dysregulated JAK/STAT signaling has been implicated in breast cancer metastasis, which is associated with high relapse risks. However, mechanisms underlying JAK/STAT signaling-mediated breast tumorigenesis are poorly understood. Here, we showed that GRAMD1B expression is upregulated on IL-6 but downregulated upon treatment with the JAK2 inhibitor AG490 in the breast cancer MDA-MB-231 cells. Notably, Gramd1b knockdown caused morphological changes of the cells, characterized by the formation of membrane ruffling and protrusions, implicating its role in cell migration...
June 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29934362/role-of-rnf20-in-cancer-development-and-progression-a-comprehensive-review
#6
Gautam Sethi, Muthu K Shanmugam, Frank Arfuso, Alan Prem Kumar
Evolving strategies to counter cancer initiation and progression rely on the identification of novel therapeutic targets that exploit the aberrant genetic changes driving oncogenesis. Several chromatin associated enzymes have been shown to influence post-translational modification on DNA, histones, and non-histone proteins. Any deregulation of this core group of enzymes often leads to cancer development. Ubiquitylation of histone H2B in mammalian cells was identified over three decades ago. An exciting really interesting new gene (RING) family of E3 ubiquitin ligases, known as RNF20 and RNF40, monoubiquitinates histone H2A at K119 or H2B at K120 and is known to function in transcription elongation, DNA double strand break repair processes, maintenance of chromatin differentiation, and exerting tumor suppressor activity...
June 22, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29933761/metabolomic-and-bh3-profiling-of-esophageal-cancers-novel-assessment-methods-for-precision-therapy
#7
R Taylor Ripley, Deborah R Surman, Laurence P Diggs, Jane B Trepel, Min-Jung Lee, Jeremy Ryan, Jeremy L Davis, Seth M Steinberg, Jonathan M Hernandez, Choung Hoang, Cara M Kenney, Colleen D Bond, Tricia F Kunst, Anthony Letai, David S Schrump
BACKGROUND: Esophageal cancers accounted for nearly 16,000 deaths in 2016. The number of patients with esophageal cancers increases every year. Neoadjuvant chemoradiotherapy (nCRT) prior to esophagectomy is a standard treatment for esophageal cancers. The patients who have no residual tumor (pathological complete response (pCR)) at surgery are the most likely to experience long term survival. Accurately determining which patients will have a pCR will improve prognostic information for patients and families, confirm lack of response to nCRT, or avoid surgery if no residual tumor is present...
June 22, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29933308/hopelessness-death-anxiety-and-social-support-of-hospitalized-patients-with-gynecologic-cancer-and-their-caregivers
#8
Fatma Uslu-Sahan, Fusun Terzioglu, Gulten Koc
BACKGROUND: Gynecologic cancer can create hopelessness and death anxiety and alter the lifestyle of the affected women and their caregivers. Perceived social support may facilitate coping with this illness. OBJECTIVE: The aim of this study was to determine whether hospitalized patients with gynecologic cancer and their caregivers differ in feelings of hopelessness and death anxiety and how those conditions may be related to their social support. METHODS: Two hundred patients with gynecologic cancer and their 200 caregivers from 1 university hospital were enrolled in this descriptive correlational study...
June 22, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29932922/pdgf-family-function-and-prognostic-value-in-tumor-biology
#9
Michael Bartoschek, Kristian Pietras
The development and progression of a tumor depends on the close interaction of malignant cells and the supportive and suppressive tumor microenvironment. Paracrine signaling enables tumor cells to shape the surrounding tissue in order to decrease recognition by the immune system, attract blood vessels to fuel growth, change metabolic programs and induce wound healing programs. In this study, we investigate the role of the platelet-derived growth factor (PDGF) family members PDGFA, PDGFB, PDGFC and PDGFD and their cognate tyrosine kinase receptors PDGFRA and PDGFRB, using publicly available data from The Cancer Genome Atlas and the Human Protein Atlas...
June 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29932898/ube2m-is-a-stress-inducible-dual-e2-for-neddylation-and-ubiquitylation-that-promotes-targeted-degradation-of-ube2f
#10
Weihua Zhou, Jie Xu, Mingjia Tan, Haomin Li, Hua Li, Wenyi Wei, Yi Sun
UBE2M and UBE2F are two family members of neddylation E2 conjugating enzyme that, together with E3s, activate CRLs (Cullin-RING Ligases) by catalyzing cullin neddylation. However, whether and how two E2s cross-talk with each other are largely unknown. Here, we report that UBE2M is a stress-inducible gene subjected to cis-transactivation by HIF-1 and AP1, and MLN4924, a small molecule inhibitor of E1 NEDD8-activating enzyme (NAE), upregulates UBE2M via blocking degradation of HIF-1α and c-JUN. UBE2M is a dual E2 for targeted ubiquitylation and degradation of UBE2F, acting as a neddylation E2 to activate CUL3-Keap1 E3 under physiological conditions but as a ubiquitylation E2 for Parkin-DJ-1 E3 under stressed conditions...
June 21, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29932835/the-palliative-chemotherapy-decision-and-experiences-of-south-african-patients-and-their-families
#11
Theola Potgieter, Johanna E Maree
AIMS: To describe what motivates cancer patients, treated at a private cancer care centre in Port Elizabeth, South Africa, to undergo palliative chemotherapy and how the patients and their families experienced this treatment. METHODS: A descriptive qualitative design was used. Researchers conducted 22 in-depth interviews with 11 purposively selected patients and 11 family members nominated by the patients. Qualitative content analysis was used to analyse the data...
June 2, 2018: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/29932472/evolution-of-sialic-acids-implications-in-xenotransplant-biology
#12
REVIEW
Anu Paul, Vered Padler-Karavani
All living cells are covered with a dense "sugar-coat" of carbohydrate chains (glycans) conjugated to proteins and lipids. The cell surface glycome is determined by a non-template driven process related to the collection of enzymes that assemble glycans in a sequential manner. In mammals, many of these glycans are topped with sialic acids (Sia), a large family of acidic sugars. The "Sialome" is highly diverse owing to various Sia types, linkage to underlying glycans, range of carriers, and complex spatial organization...
June 22, 2018: Xenotransplantation
https://www.readbyqxmd.com/read/29931806/the-polypeptide-n-acetylgalactosaminyltransferase-4-exhibits-stage-dependent-expression-in-colorectal-cancer-and-affects-tumorigenesis-invasion-and-differentiation
#13
Xialin Yan, Jishun Lu, Xia Zou, Sen Zhang, Yalu Cui, Leqi Zhou, Feng Liu, Aidong Shan, Jiaoyang Lu, Minghua Zheng, Bo Feng, Yan Zhang
The aberrant expression of mucin-type O-glycosylation plays important roles in the cancer malignancy. Polypeptide N-acetylgalactosaminyltransferases (ppGalNAc-Ts) are a family of conserved enzymes that initiate the mucin-type O-glycosylation in cells. In human, consistent up- or down-regulation of ppGalNAc-Ts expression during the cancer development has been frequently reported. Here, we provide evidence that ppGalNAc-T4 shows a stage-dependent expression at the different stages of colorectal cancer (CRC) in the 62 pair-matched tumor/normal tissues...
June 22, 2018: FEBS Journal
https://www.readbyqxmd.com/read/29931745/cold-atmospheric-plasma-induces-apoptosis-of-melanoma-cells-via-sestrin2-mediated-inos-signaling
#14
Jun Xia, Weihui Zeng, Yumin Xia, Bingchuan Wang, Dehui Xu, Dingxin Liu, Michael G Kong, Yingying Dong
Cold atmospheric plasma (CAP) represents a promising therapy for selectively cancer killing. However, the mechanism of CAP-induced cancer cell death remains unclear. Here, we identified the tumor necrosis factor (TNF)-family members, especially Fas, and overloaded intracellular nitric oxide (NO) participated in CAP induced apoptosis in A375 and A875 melanoma cell lines, which was known as extrinsic apoptosis pathway. This progress was mediated by antagonistic protein of reactive oxygen species (ROS), Sestrin2...
June 22, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29931357/radon-and-thoron-progeny-in-dutch-dwellings
#15
R C G M Smetsers, R O Blaauboer, F Dekkers, H Slaper
Radon and thoron progenies in Dutch dwellings cause ~400 cases of lung cancer per year. Some 30% of the risk is due to thoron progeny, which demonstrates that the influence of thoron progeny is much larger than previously anticipated. This was concluded from a national survey in 2500 Dutch dwellings, built since 1930. Radon concentrations (15.6 ± 0.3 Bq m-3 on average) are correlated to type of dwelling, year of construction, ventilation system, location (soil type) and smoking behaviour of inhabitants. The survey data support the establishment of a comparatively low national reference level for radon in dwellings in the Netherlands of 100 Bq m-3, in line with recommendations by WHO and ICRP...
June 19, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29930759/wnk1-kinase-and-its-partners-akt-sgk1-and-nbc-family-na-hco3-cotransporters-are-potential-therapeutic-targets-for-glioblastoma-stem-like-cells-linked-to-bisacodyl-signaling
#16
Wanyin Chen, Leonel Nguekeu Zebaze, Jihu Dong, Laëtitia Chézeau, Perrine Inquimbert, Sylvain Hugel, Songlin Niu, Fréderic Bihel, Emmanuel Boutant, Eléonore Réal, Pascal Villa, Marie-Pierre Junier, Hervé Chneiweiss, Marcel Hibert, Jacques Haiech, Marie-Claude Kilhoffer, Maria Zeniou
Glioblastoma is a highly heterogeneous brain tumor. The presence of cancer cells with stem-like and tumor initiation/propagation properties contributes to poor prognosis. Glioblastoma cancer stem-like cells (GSC) reside in hypoxic and acidic niches favoring cell quiescence and drug resistance. A high throughput screening recently identified the laxative Bisacodyl as a cytotoxic compound targeting quiescent GSC placed in acidic microenvironments. Bisacodyl activity requires its hydrolysis into DDPM, its pharmacologically active derivative...
June 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29930434/the-chinese-children-and-families-cohort-study-the-nutrition-physical-activity-and-ultraviolet-radiation-data-collection
#17
Nancy Potischman, Liwen Fang, Ling Hao, Regan R Bailey, David Berrigan, Robert John Berry, Alison Brodie, Ann Chao, Jing Chen, Kevin Dodd, Yajing Feng, Guansheng Ma, Yuna He, Jing Fan, Michael Kimlin, Cari Kitahara, Martha Linet, Zhu Li, Ailing Liu, Yashan Liu, Joshua Sampson, Joseph Su, Jiandong Sun, Natasha Tasevska, Lichen Yang, Ruilan Yang, Qian Zhang, Ning Wang, Linhong Wang, Wang Yu
This article reports the study design, methodological issues and early results of a pilot study testing methods for collecting nutrition, physical activity, and ultraviolet (UV) radiation exposure data in a groundbreaking study in China. Epidemiological studies suggest that exposures across the entire life course, including in utero, early childhood, and adolescence, may be important in the etiology of adult cancers and other chronic diseases. The Chinese Children and Families Cohort Study intends to follow-up subjects from the 1993 to 1995 Community Intervention Program of folic acid supplementation for the prevention of neural tube defects...
May 2018: Nutrition Today
https://www.readbyqxmd.com/read/29930381/the-dimer-dependent-catalytic-activity-of-raf-family-kinases-is-revealed-through-characterizing-their-oncogenic-mutants
#18
Jimin Yuan, Wan Hwa Ng, Paula Y P Lam, Yu Wang, Hongping Xia, Jiajun Yap, Shou Ping Guan, Ann S G Lee, Mei Wang, Manuela Baccarini, Jiancheng Hu
Although extensively studied for three decades, the molecular mechanisms that regulate the RAF/MEK/ERK kinase cascade remain ambiguous. Recent studies identified the dimerization of RAF as a key event in the activation of this cascade. Here, we show that in-frame deletions in the β3-αC loop activate ARAF as well as BRAF and other oncogenic kinases by enforcing homodimerization. By characterizing these RAF mutants, we find that ARAF has less allosteric and catalytic activity than the other two RAF isoforms, which arises from its non-canonical APE motif...
June 21, 2018: Oncogene
https://www.readbyqxmd.com/read/29930249/comparison-of-uphold-tm-vaginal-mesh-procedure-with-hysterectomy-or-uterine-preservation-for-the-treatment-of-pelvic-organ-prolapse
#19
Chin-Ru Ker, Kun-Ling Lin, Zi-Xi Loo, Yung-Shun Juan, Cheng-Yu Long
Hysterectomy is the empirical treatment for female pelvic organ prolapse (POP) without robust evidence to prove its efficacy. Uphold transvaginal mesh (TVM) system is an innovated device with smaller area, superior anterior/apical support with single incision to treat POP. The prospective cohort study aims to evaluate Uphold TVM's performance with or without concomitant hysterectomy. Inclusion criteria specify patients suffering from stage 2 or more anterior/apical prolapse without previous hysterectomy. Exclusion criteria specify those with contraindications to uterine preservation, such as leiomyomas, adenomyosis, endometrial hyperplasia, abnormal uterine bleeding, postmenopausal bleeding, cervical dysplasia, receiving tamoxifen treatment, family history of gynecology cancer, or colon cancer and incapability to be routinely followed...
June 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29930174/a-hif-limd1-negative-feedback-mechanism-mitigates-the-pro-tumorigenic-effects-of-hypoxia
#20
Daniel E Foxler, Katherine S Bridge, John G Foster, Paul Grevitt, Sean Curry, Kunal M Shah, Kathryn M Davidson, Ai Nagano, Emanuela Gadaleta, Hefin I Rhys, Paul T Kennedy, Miguel A Hermida, Ting-Yu Chang, Peter E Shaw, Louise E Reynolds, Tristan R McKay, Hsei-Wei Wang, Paulo S Ribeiro, Michael J Plevin, Dimitris Lagos, Nicholas R Lemoine, Prabhakar Rajan, Trevor A Graham, Claude Chelala, Kairbaan M Hodivala-Dilke, Ian Spendlove, Tyson V Sharp
The adaptive cellular response to low oxygen tensions is mediated by the hypoxia-inducible factors (HIFs), a family of heterodimeric transcription factors composed of HIF-α and HIF-β subunits. Prolonged HIF expression is a key contributor to cellular transformation, tumorigenesis and metastasis. As such, HIF degradation under hypoxic conditions is an essential homeostatic and tumour-suppressive mechanism. LIMD1 complexes with PHD2 and VHL in physiological oxygen levels (normoxia) to facilitate proteasomal degradation of the HIF-α subunit...
June 21, 2018: EMBO Molecular Medicine
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