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incidence of gall bladder carcinoma in india

Shipra Dwivedi, Sarita Agrawal, Shraddha Singh, Amit Kumar Madeshiya, Devendra Singh, Abbas Ali Mahdi, Abhjeet Chandra
BACKGROUND: Cholelithiasis is associated in 54%-98% of patients with carcinoma of the gallbladder, and a high incidence among females suggests a role of female hormones in the etiology of the disease. Cytochrome P450C17α (CYP-17) is a key enzyme involved in estrogen metabolism and polymorphisms in CYP-17 are associated with altered serum levels of estrogens. Thus, we investigated whether the CYP-17 MspA1 gene polymorphism might impact on risk of gall bladder cancers or gallstones, as well as to determine if this gene polymorphism might be linked with estrogen serum levels and lipid profile among the North Indian gall bladder cancer or gallstone patients...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Hanni V Gulwani, Suneeta Gupta, Sukhpreet Kaur
Carcinoma of gall bladder is the most common malignancy of the biliary tract worldwide and is usually associated with poor prognosis. In this era of laparoscopic cholecystectomy, there has been increase in detection of early stage incidental gall bladder carcinoma in cholecystectomy specimens. A retrospective study was carried out in tertiary care hospital in central India. A total of 2990 patients underwent laparoscopic cholecystectomy during the year 2001-2013. Hospital records and histopathology reports of these patients were studied in detail...
March 2015: Indian Journal of Surgical Oncology
Munesh K Sharma, Tarundeep Singh, Avdesh K Pandey, Ankita Kankaria
BACKGROUND: Cancer has become an epidemic disease. Nearly ten million new cancer cases are diagnosed annually in the world and out of these about half are from the developing world. To appropriately plan for treatment, management and prevention of the disease, it becomes necessary to study the trends about morbidity caused by cancers. MATERIALS AND METHODS: Data for patients diagnosed with any form of gastrointestinal (GI) cancers was extracted from records maintained in the outpatient department registers of the Oncology Department of Government Medical College and Hospital in Chandigarh from 1999 to 2012...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Mustafa Barbhuiya, Shushruta Bhunia, Manisha Kakkar, Braj Shrivastava, Pramod K Tiwari, Sanjiv Gupta
BACKGROUND: Patients presenting with mass lesions of liver and gallbladder are a common occurrence in a cancer hospital in north central part of India. Fine-needle aspiration cytology (FNAC) serves as first line of pathological investigations, but there are pros and cons involved. AIM: The main objective of the present study was to establish adequacy of the procedure and to find out diagnostic pitfalls. An attempt was made to analyze inconclusive and inadequate aspirations...
January 2014: Journal of Cytology
Imran Khan, Nilanjan Panda, Manju Banerjee, Ruchira Das
India has high incidence of Gallbladder carcinoma with regional variation in incidence possibly due to environmental factors. Prospective study of all the gall bladder cancer in our hospital over 18 months analysing how the epidemiological factors are influencing the disease. Incidence-Four cases per 100,000 populations per year. The peak incidence was in 41 to 50 years group (49.20 %). Male to female ratio was 1:3.8. Majority (69.84 %) were in lower socio-economic group. 61 out of 63 patients (96.62 %) were non-vegetarians...
March 2013: Indian Journal of Surgical Oncology
Dipti Kalita, Leela Pant, Sompal Singh, Gaurav Jain, Madhur Kudesia, Kusum Gupta, Charanjeet Kaur
Gall bladder carcinoma is the most common cancer of biliary tree, characterized by rapid progression and a very high mortality rate. Detection at an early stage, however, is indicative of a very good prognosis and prolonged survival. The practice of histopathological examination of gall bladder specimens removed for clinically benign conditions and its usefulness has been a subject of controversy. The present prospective study was carried out over a period of four years in order to find out the incidence of unsuspected gallbladder carcinoma in cholecystectomy specimens received in our histopathology laboratory and to analyze their clinico-pathological features...
2013: Asian Pacific Journal of Cancer Prevention: APJCP
Nissar Hussain Hamdani, Sumyra Khurshid Qadri, Ramesh Aggarwalla, Vishnu Kumar Bhartia, Sumit Chaudhuri, Sanjay Debakshi, Sarfaraz Jalil Baig, N K Pal
Gallbladder carcinoma (GBC) is the commonest cancer of the biliary tree and the most frequent cause of death from biliary malignancies. The incidence of GBC shows prominent geographic, age, race, and gender-related differences and is 4-7 times higher in patients with gallstones. This prompted us to study the clinicopathological aspects of the disease and the incidence of gallstones in gallbladder carcinoma patients, in this part of India. In this, combined retrospective (Jan 2004-March 2010) and prospective study (April 2010-Dec 2011) of eight years, 198 patients of gallbladder carcinoma (50 males and 148 females), (range 28-82 years; mean 55 years) were studied...
2012: Asian Pacific Journal of Cancer Prevention: APJCP
Swati Bera, Swati Bhattacharyya, Bikash C Ghose, Tapas Bera, Surajit K Mukhopadhyay, Mita Saha
Silent gall-stone causes significant morbidity and mortality and its incidence in India as well as in whole world is on the rise. It has positive correlation with development of carcinoma gall bladder. So far no predictive study has been done to show its correlation with biochemical markers. The present study has been aimed to establish whether simple enzymatic markers can predict association with cholelithiasis. Study group has been selected from the patients attending general surgery OPD of a tertiary healthcare centre with complaints of vague abdominal pain, flatulence and dyspepsia...
September 2011: Journal of the Indian Medical Association
Om Tantia, Mayank Jain, Shashi Khanna, Bimalendu Sen
INTRODUCTION: Carcinoma gall bladder (CaGB) is a disease with high mortality and is usually diagnosed as an incidental case among patients undergoing laparoscopic cholecystectomy (LC) for symptomatic gall stone disease. METHODS: A total of 3205 LC done between January 2004 and August 2007 for symptomatic gall stone disease were retrospectively searched for incidental CaGB (detected on histopathology). None of these cases had preoperative suspicion of malignancy and their whole data was analyzed with special attention to preoperative and intraoperative findings which could raise suspicion of CaGB...
September 2009: Surgical Endoscopy
Mukul Das, Kausar M Ansari, Alok Dhawan, Yogeshwer Shukla, Subhash K Khanna
In recent times, a higher incidence of gall bladder carcinoma in the Indo-Gangetic basin has been linked with the consumption of contaminated mustard oil. Consumption of mustard oil contaminated with argemone oil (AO) is well known to cause clinical manifestation referred to as "epidemic dropsy." Because sanguinarine, an active alkaloid of AO, has been shown to intercalate DNA, a possible correlation of DNA damage in epidemic dropsy patients to tumorigenic potential of AO and isolated sanguinarine alkaloid in mice was investigated in the present study...
December 10, 2005: International Journal of Cancer. Journal International du Cancer
R V Raghavendra Rao, Ashok Kumar, Sadiq S Sikora, Rajan Saxena, Vinay K Kapoor
Xanthogranulomatous cholecystitis (XGC) is a destructive form of chronic cholecystitis. In some patients it coexists with gall bladder carcinoma (GBC) and is often difficult to differentiate between the two. Present study was performed with an aim to identify differentiating features of XGC and those of XGC with associated Gall bladder carcinoma (XGC ass. GBC). A retrospective analysis of prospectively maintained data of 4800 cholecystectomies performed from January 1988 to December 2003 was carried out. On histopathology 453 cholecystectomy specimens revealed XGC...
January 2005: Tropical Gastroenterology: Official Journal of the Digestive Diseases Foundation
S P Tyagi, N Tyagi, V Maheshwari, S M Ashraf, P Sahoo
Morphological changes of gall bladder were studied in 415 cholecystectomy specimens. There was a preponderance of females (male to female ratio--1:6.5). The mean age of the cases was 43.6 years. Most of the cases (63.4%) were in the 4th and 5th decades of life. The average duration of illness was 2.8 years. Associated cholelithiasis was present in 85.3% cases. Gall-stones were of mixed variety in 78.2% cases, cholesterol type in 15.3% cases and both types were present in 6.5% cases. Chronic cholecystitis was the main histological diagnosis (50...
July 1992: Journal of the Indian Medical Association
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