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Streptococcus group a bacteremia

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https://www.readbyqxmd.com/read/28192236/diagnosis-of-primary-antibody-and-complement-immunodeficiencies-in-young-adults-after-a-first-invasive-bacterial-infection
#1
Sébastien Sanges, Frédéric Wallet, Nicolas Blondiaux, Didier Theis, Isabelle Verin, Anne Vachée, Rodrigue Dessein, Karine Faure, Nathalie Viget, Eric Senneville, Olivier Leroy, Fleur Maury, Nicolas Just, Julien Poissy, Daniel Mathieu, Anne Prévotat, Cécile Chenivesse, Arnaud Scherpereel, Grégoire Smith, Benjamin Lopez, Jérémie Rosain, Véronique Fremeaux-Bacchi, Eric Hachulla, Pierre-Yves Hatron, Mathilde Bahuaud, Frédéric Batteux, David Launay, Myriam Labalette, Guillaume Lefèvre
OBJECTIVES: Screening for primary immunodeficiencies (PIDs) in adults is recommended after two severe bacterial infections. We aimed to evaluate if screening should be performed after the first invasive infection in young adults. METHODS: Eligible patients were retrospectively identified using hospital discharge and bacteriology databases in 3 centers during a 3-year period. Eighteen to forty year-old patients were included if they had experienced an invasive infection with encapsulated bacteria commonly encountered in PIDs (Streptococcus pneumoniae (SP), Neisseria meningitidis (NM), Neisseria gonorrhoeae (NG), Haemophilus influenzae (HI) or group A Streptococcus (GAS))...
February 10, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28121169/development-of-a-dna-aptamer-that-binds-specifically-to-group-a-streptococcus-serotype-m3
#2
Hanif Alfavian, Seyed Latif Mousavi Gargari, Samaneh Rasoulinejad, Arvin Medhat
Group A streptococcus (GAS) is an important Gram-positive pathogen that causes various human diseases ranging from peripheral lesions to invasive infections. The M protein is one of the main virulence factors present on the cell surface and is associated with invasive GAS infections. Compared with other M types, serotype M3 has a predominant role in lethal infections and demonstrates epidemic behaviors, including streptococcal toxic shock syndrome, bacteremia, and necrotizing fasciitis. Traditional methods for M typing are time-consuming, tedious, contradictory, and generally restricted to reference laboratories...
February 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/28100999/colorectal-cancer-associated-with-streptococcus-anginosus-bacteremia-and-liver-abscesses
#3
Umair Masood, Anuj Sharma, Dhruv Lowe, Rashad Khan, Divey Manocha
Streptococcus anginosus is part of the normal flora of the human gastrointestinal tract. Their ability to cause abscesses is very unique and sets them apart from the rest of the streptococci groups. While an association of group D streptococcus bacteremia and endocarditis with colorectal carcinoma is well established, S. anginosus infections are rarely implicated with colonic malignancy. We present a case of a 62-year-old male who presented to the hospital with fatigue and generalized abdominal pain. Computed tomography of the abdomen revealed multiple liver abscesses and rectal thickening...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28096994/multiple-liver-abscesses-and-bacteremia-caused-by-streptococcus-constellatus-infection-a-case-report
#4
Nobuhiro Akuzawa, Takashi Hatori, Yonosuke Kitahara, Masahiko Kurabayashi
The Streptococcus milleri group (SMG) comprises commensal mucosal bacteria. Pyogenic liver abscesses due to hematogenous SMG infection are rare but can be observed even in healthy patients. In such cases, physicians should consider the existence of primary lesions that allow penetration of the SMG.
January 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28061775/immunization-with-streptococcus-suis-bacterin-plus-recombinant-sao-protein-in-sows-conveys-passive-immunity-to-their-piglets
#5
RANDOMIZED CONTROLLED TRIAL
Kai-Jen Hsueh, Li-Ting Cheng, Jai-Wei Lee, Yao-Chi Chung, Wen-Bin Chung, Chun-Yen Chu
BACKGROUND: Streptococcus suis (S. suis) causes arthritis, meningitis, septicemia, and sudden death in pigs and is also an zoonotic agent for humans. The present study demonstrated that immunization with recombinant Sao-L (surface antigen one-L, rSao-L) protein from a strain of S. suis serotype 2 in pigs was able to increase cross-serotype protection against S. suis serotype 1 and 2 challenge. Since weaning piglets are more susceptible to S. suis infections due to the stresses associated with weaning, prepartum immunization in sows may convey passive immunity to piglets and provide protection...
January 7, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/27989049/infective-endocarditis-in-hemodialysis-patients
#6
Rahul Vasudev, Priyank Shah, Supreet Kaur, Chandrika Chitturi, Sundermurthy Yamini, Ashesha Mechineni, Chandra Chandran, Mahesh Bikkina, Fayez Shamoon
BACKGROUND: Infective endocarditis (IE) is a major cause of morbidity and mortality in patients with end-stage renal disease (ESRD). The study aim was to evaluate the demographic, clinical, microbiological and inpatient mortality data of IE in hemodialysis patients. METHODS: Data were analyzed for all IE patients admitted to the authors' 800-bed tertiary care hospital between January 2001 and December 2014. These data included demographics, comorbidities, clinical and microbiological characteristics, echocardiographic findings, complications, outcomes, and in-patient mortality...
May 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27884476/systemic-immunization-with-rpotd-reduces-streptococcus-pneumoniae-nasopharyngeal-colonization-in-mice
#7
T R Converso, C Goulart, D Rodriguez, M Darrieux, L C C Leite
Streptococcus pneumoniae (pneumococcus) is a human pathogen that can cause otitis media, pneumonia and, in severe cases, meningitis and bacteremia. The pneumococcus expresses PotD, a protein belonging to the polyamines transporter complex called PotABCD. PotD is a membrane-associated protein that binds polyamines and has been shown to be important for virulence. In this work we demonstrate that subcutaneous immunization with rPotD reduces the bacterial load in the nasal tissue of mice, following intranasal challenge with a type 6B pneumococcus...
January 3, 2017: Vaccine
https://www.readbyqxmd.com/read/27870814/the-contemporary-microbiology-and-rates-of-concomitant-osteomyelitis-in-acute-septic-arthritis
#8
Jessica Branson, Jesus G Vallejo, Anthony R Flores, Kristina G Hulten, Edward O Mason, Sheldon L Kaplan, J Chase McNeil
BACKGROUND: Septic arthritis (SA) and acute osteomyelitis (AO) are among the most common serious bacterial infections of childhood. Knowledge of the microbiology of SA is critical to treatment. Awareness of the presence of attendant AO is also important to guide clinical management. We sought to describe the current microbiology of SA in children and clinical features associated with coexisting AO. MATERIALS AND METHODS: Patients with SA were identified from the infectious diseases consult service records from 2010 to 2014...
March 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27767904/group-b-streptococcus-serotype-iii-sequence-type-283-bacteremia-associated-with-consumption-of-raw-fish-singapore
#9
Shermin Tan, Yijun Lin, Kelly Foo, Han Fang Koh, Charlene Tow, Yiwen Zhang, Li Wei Ang, Lin Cui, Hishamuddin Badaruddin, Peng Lim Ooi, Raymond Tzer Pin Lin, Jeffery Cutter
We conducted a retrospective study of 40 case-patients and 58 controls as part of a nationwide investigation of a group B Streptococcus outbreak in Singapore in 2015. Eating a Chinese-style raw fish dish (yusheng) was a major risk factor for bacteremia, particularly caused by serotype III sequence type 283.
November 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27767008/immune-responses-to-invasive-group-b-streptococcal-disease-in-adults
#10
Morven S Edwards, Marcia A Rench, C Daniela Rinaudo, Monica Fabbrini, Giovanna Tuscano, Giada Buffi, Erika Bartolini, Stefano Bonacci, Carol J Baker, Immaculada Margarit
Immunization of nonpregnant adults could help prevent invasive group B Streptococcus (GBS) infections, but adult immune responses have not been investigated. We defined capsular polysaccharide (CPS) and pilus island (PI) surface antigen distribution and expression and immune responses to GBS infection in nonpregnant adults. Prospective surveillance from 7 hospitals in Houston, Texas, USA, identified 102 adults with GBS bacteremia; 43% had skin/soft tissue infection, 16% bacteremia without focus, and 12% osteomyelitis...
November 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27767002/experience-with-rapid-microarray-based-diagnostic-technology-and-antimicrobial-stewardship-for-patients-with-gram-positive-bacteremia
#11
Elizabeth A Neuner, Andrea M Pallotta, Simon W Lam, David Stowe, Steven M Gordon, Gary W Procop, Sandra S Richter
OBJECTIVE To describe the impact of rapid diagnostic microarray technology and antimicrobial stewardship for patients with Gram-positive blood cultures. DESIGN Retrospective pre-intervention/post-intervention study. SETTING A 1,200-bed academic medical center. PATIENTS Inpatients with blood cultures positive for Staphylococcus aureus, Enterococcus faecalis, E. faecium, Streptococcus pneumoniae, S. pyogenes, S. agalactiae, S. anginosus, Streptococcus spp., and Listeria monocytogenes during the 6 months before and after implementation of Verigene Gram-positive blood culture microarray (BC-GP) with an antimicrobial stewardship intervention...
November 2016: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/27720091/ongoing-cases-of-early-onset-group-b-streptococcal-disease-in-the-era-of-screening-and-prophylaxis
#12
Vanessa Poliquin, Elissa Cohen, Philippe Guillaume Poliquin, Carol Schneider, Savas Menticoglou
OBJECTIVE: We reviewed cases of group B Streptococcus (GBS) sepsis in term infants at our institution to identify areas for potential prevention. METHODS: We identified cases by searching our institution's microbiology databases for all positive GBS blood and cerebrospinal fluid cultures taken from infants between 2008 and 2013. Patients were included if the timing of the positive culture met the criteria for early-onset GBS disease (age 7 days or under). Charts that met inclusion criteria were abstracted for details related to antepartum screening, intrapartum care, and postpartum outcome...
October 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/27630763/intra-abdominal-abscess-and-primary-peritonitis-caused-by-streptococcus-anginosus
#13
Huseyin Agah Terzi, Tayfur Demiray, Mehmet Koroglu, Guner Cakmak, Ihsan Hakki Ciftci, Ahmet Ozbek, Mustafa Altindis
INTRODUCTION: The Streptococcus anginosus group of bacteria are low-virulence bacteria existing as commensals in the oral flora and gastrointestinal tracts of humans. S. anginosus may spread to the blood in individuals with poor oral hygiene in cases of oral infections, such as gingivitis and tooth abscesses, that develop following the loss of mucosal unity. This may lead to infections in the whole body, primarily as brain and liver abscesses. CASE PRESENTATION: A 32-year-old male patient presented with complaints of nausea, vomiting, and diffuse abdominal pain...
June 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27558182/molecular-characteristics-of-group-b-streptococci-isolated-from-adults-with-invasive-infections-in-japan
#14
Miyuki Morozumi, Takeaki Wajima, Misako Takata, Satoshi Iwata, Kimiko Ubukata
Streptococcus agalactiae (group B streptococcus) isolates (n = 443) obtained from Japanese adults with invasive infections between April 2010 and March 2013 were analyzed for capsular serotype, multilocus sequence type (ST), antibiotic susceptibility, and resistance genes. Among these cases, bacteremia without primary focus was the most common variety of infection (49.9%), followed by cellulitis (12.9%) and pneumonia (9.0%). Concerning patient age (18 to 59, 60 to 69, 70 to 79, 80 to 89, and 90 years old or older), the incidence of pneumonia increased in patients in their 70s and 80s (P < 0...
November 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27527222/genomic-recombination-leading-to-decreased-virulence-of-group-b-streptococcus-in-a-mouse-model-of-adult-invasive-disease
#15
Sarah Teatero, Paul Lemire, Ken Dewar, Jessica Wasserscheid, Cynthia Calzas, Gustavo V Mallo, Aimin Li, Taryn B T Athey, Mariela Segura, Nahuel Fittipaldi
Adult invasive disease caused by Group B Streptococcus (GBS) is increasing worldwide. Whole-genome sequencing (WGS) now permits rapid identification of recombination events, a phenomenon that occurs frequently in GBS. Using WGS, we described that strain NGBS375, a capsular serotype V GBS isolate of sequence type (ST)297, has an ST1 genomic background but has acquired approximately 300 kbp of genetic material likely from an ST17 strain. Here, we examined the virulence of this strain in an in vivo model of GBS adult invasive infection...
August 5, 2016: Pathogens
https://www.readbyqxmd.com/read/27460295/bacteremia-due-to-streptococcus-tigurinus-a-case-report-and-literature-review
#16
Jun Hirai, Daisuke Sakanashi, Mao Hagihara, Shusaku Haranaga, Kohei Uechi, Hideo Kato, Hiroyuki Hamada, Naoya Nishiyama, Yusuke Koizumi, Hiroyuki Suematsu, Yuka Yamagishi, Jiro Fujita, Hiroshige Mikamo
Gene sequence analysis methods, including 16S rRNA identification, allows accurate identification of Streptococcus species, which include phenotypically closely related species that are difficult to differentiate using conventional chemical methods. We report a case of bacteremia due to Streptococcus tigurinus, identified by 16S rRNA, in a 72-year-old woman with gastrointestinal cancer and ascites. She was hospitalized to undergo elective tumor-related surgery. Five days prior to undergoing surgery, she developed a fever with no obvious source of infection...
November 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27440820/broad-range-pcr-coupled-with-electrospray-ionization-time-of-flight-mass-spectrometry-for-detection-of-bacteremia-and-fungemia-in-patients-with-neutropenic-fever
#17
S Desmet, J Maertens, K Bueselinck, K Lagrou
Infection is an important complication in patients with hematologic malignancies or solid tumors undergoing intensive cytotoxic chemotherapy. In only 20 to 30% of the febrile neutropenic episodes, an infectious agent is detected by conventional cultures. In this prospective study, the performance of broad-range PCR coupled with electrospray ionization time of flight mass spectrometry (PCR/ESI-MS) technology was compared to conventional blood cultures (BC) in a consecutive series of samples from high-risk hematology patients...
October 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27434828/complications-of-pneumococcal-bacteremia-after-13-valent-conjugate-vaccine-withdrawal
#18
Alfredo Tagarro, Patricia Bote, Aida Sánchez, Enrique Otheo, Juan-Carlos Sanz, David Sanz-Rosa
BACKGROUND: In the Region of Madrid, universal immunization with the 13-serotypes pneumococcal conjugate vaccine (PCV13) started in May 2010. In July 2012, public funding ceased. Vaccination coverage decreased from >95% to 82% in 2013 and to 67% in 2014. Our aim was to investigate the impact of PCV13 withdrawal from Madrid Region's universal immunization program on the incidence of complicated pneumococcal bacteremia. METHODS: We performed a multi-center retrospective cohort study, from 2009 to 2014...
July 18, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27325440/molecular-characterization-and-antibiotic-resistance-of-group-g-streptococci-in-israel-comparison-of-invasive-non-invasive-and-carriage-isolates
#19
T Halperin, H Levine, Z Korenman, S Burstein, R Amber, T Sela, L Valinsky
Beta-hemolytic group G streptococci (GGS) are increasingly recognized as a source of substantial morbidity, causing mild to severe sporadic infections as well as outbreaks. The purpose of this study was to determine the genetic diversity and antibiotic resistance of GGS in Israel in order to aid in prevention and control. A total of 325 GGS isolates were collected in Israel between 2007 and 2011 from three determined settings: (1) carriage (n = 60), an observational longitudinal carriage study in the IF, (2) non-invasive (n = 166), clinical sporadic and epidemic non-invasive cases in the IDF, and (3) invasive (n = 99) cases of bacteremia collected during this period in Israel from a similar age group, at the national Streptococcal Reference Center...
October 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27258513/clinical-features-and-outcomes-of-spontaneous-bacterial-peritonitis-caused-by-streptococcus-pneumoniae-a-matched-case-control-study
#20
Taeeun Kim, Sun In Hong, Se Yoon Park, Jiwon Jung, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Yang Soo Kim, Jun Hee Woo, Young-Suk Lim, Heungsup Sung, Mi-Na Kim, Sang-Ho Choi
Streptococcus pneumoniae is a well-known cause of spontaneous bacterial peritonitis (SBP) in cirrhotic patients. However, little information is available regarding clinical characteristics and outcomes of SBP caused by S. pneumoniae. It has been suggested that spontaneous pneumococcal peritonitis (SPP) often spreads hematogenously from concomitant pneumococcal pneumonia, and is associated with a higher rate of mortality.During the period between January 1997 and December 2013, 50 SPP cases were identified. These cases were then age/sex-matched with 100 patients with SBP due to causes other than S...
May 2016: Medicine (Baltimore)
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