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Streptococcus group a bacteremia

T R Converso, C Goulart, D Rodriguez, M Darrieux, L C C Leite
Streptococcus pneumoniae (pneumococcus) is a human pathogen that can cause otitis media, pneumonia and, in severe cases, meningitis and bacteremia. The pneumococcus expresses PotD, a protein belonging to the polyamines transporter complex called PotABCD. PotD is a membrane-associated protein that binds polyamines and has been shown to be important for virulence. In this work we demonstrate that subcutaneous immunization with rPotD reduces the bacterial load in the nasal tissue of mice, following intranasal challenge with a type 6B pneumococcus...
November 21, 2016: Vaccine
Jessica Branson, Jesus G Vallejo, Anthony R Flores, Kristina G Hulten, Edward O Mason, Sheldon L Kaplan, J Chase McNeil
BACKGROUND: Septic arthritis (SA) and acute osteomyelitis (AO) are among the most common serious bacterial infections of childhood. Knowledge of the microbiology of SA is critical to treatment. Awareness of the presence of attendant AO is also important to guide clinical management. We sought to describe the current microbiology of SA in children as well as describe clinical features associated with coexisting AO. MATERIALS AND METHODS: Patients with SA were identified from the infectious diseases consult service records from 2010-2014...
November 18, 2016: Pediatric Infectious Disease Journal
Shermin Tan, Yijun Lin, Kelly Foo, Han Fang Koh, Charlene Tow, Yiwen Zhang, Li Wei Ang, Lin Cui, Hishamuddin Badaruddin, Peng Lim Ooi, Raymond Tzer Pin Lin, Jeffery Cutter
We conducted a retrospective study of 40 case-patients and 58 controls as part of a nationwide investigation of a group B Streptococcus outbreak in Singapore in 2015. Eating a Chinese-style raw fish dish (yusheng) was a major risk factor for bacteremia, particularly caused by serotype III sequence type 283.
November 2016: Emerging Infectious Diseases
Morven S Edwards, Marcia A Rench, C Daniela Rinaudo, Monica Fabbrini, Giovanna Tuscano, Giada Buffi, Erika Bartolini, Stefano Bonacci, Carol J Baker, Immaculada Margarit
Immunization of nonpregnant adults could help prevent invasive group B Streptococcus (GBS) infections, but adult immune responses have not been investigated. We defined capsular polysaccharide (CPS) and pilus island (PI) surface antigen distribution and expression and immune responses to GBS infection in nonpregnant adults. Prospective surveillance from 7 hospitals in Houston, Texas, USA, identified 102 adults with GBS bacteremia; 43% had skin/soft tissue infection, 16% bacteremia without focus, and 12% osteomyelitis...
November 2016: Emerging Infectious Diseases
Elizabeth A Neuner, Andrea M Pallotta, Simon W Lam, David Stowe, Steven M Gordon, Gary W Procop, Sandra S Richter
OBJECTIVE To describe the impact of rapid diagnostic microarray technology and antimicrobial stewardship for patients with Gram-positive blood cultures. DESIGN Retrospective pre-intervention/post-intervention study. SETTING A 1,200-bed academic medical center. PATIENTS Inpatients with blood cultures positive for Staphylococcus aureus, Enterococcus faecalis, E. faecium, Streptococcus pneumoniae, S. pyogenes, S. agalactiae, S. anginosus, Streptococcus spp., and Listeria monocytogenes during the 6 months before and after implementation of Verigene Gram-positive blood culture microarray (BC-GP) with an antimicrobial stewardship intervention...
November 2016: Infection Control and Hospital Epidemiology
Vanessa Poliquin, Elissa Cohen, Philippe Guillaume Poliquin, Carol Schneider, Savas Menticoglou
OBJECTIVE: We reviewed cases of group B Streptococcus (GBS) sepsis in term infants at our institution to identify areas for potential prevention. METHODS: We identified cases by searching our institution's microbiology databases for all positive GBS blood and cerebrospinal fluid cultures taken from infants between 2008 and 2013. Patients were included if the timing of the positive culture met the criteria for early-onset GBS disease (age 7 days or under). Charts that met inclusion criteria were abstracted for details related to antepartum screening, intrapartum care, and postpartum outcome...
October 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Huseyin Agah Terzi, Tayfur Demiray, Mehmet Koroglu, Guner Cakmak, Ihsan Hakki Ciftci, Ahmet Ozbek, Mustafa Altindis
INTRODUCTION: The Streptococcus anginosus group of bacteria are low-virulence bacteria existing as commensals in the oral flora and gastrointestinal tracts of humans. S. anginosus may spread to the blood in individuals with poor oral hygiene in cases of oral infections, such as gingivitis and tooth abscesses, that develop following the loss of mucosal unity. This may lead to infections in the whole body, primarily as brain and liver abscesses. CASE PRESENTATION: A 32-year-old male patient presented with complaints of nausea, vomiting, and diffuse abdominal pain...
June 2016: Jundishapur Journal of Microbiology
Miyuki Morozumi, Takeaki Wajima, Misako Takata, Satoshi Iwata, Kimiko Ubukata
Streptococcus agalactiae (group B streptococcus) isolates (n=443) obtained from Japanese adults with invasive infections between April 2010 and March 2013 were analyzed for capsular serotype, multilocus sequence typing, antibiotic susceptibility, and resistance genes. Among these cases, bacteremia without primary focus was the most common variety of infection (49.9%), followed by cellulitis (12.9%) and pneumonia (9.0%). Concerning patient age (18 to 59 years, the 60s, 70s, and 80s, and the 90s or older), the incidence of pneumonia increased in the 70s and 80s (P<0...
August 24, 2016: Journal of Clinical Microbiology
Sarah Teatero, Paul Lemire, Ken Dewar, Jessica Wasserscheid, Cynthia Calzas, Gustavo V Mallo, Aimin Li, Taryn B T Athey, Mariela Segura, Nahuel Fittipaldi
Adult invasive disease caused by Group B Streptococcus (GBS) is increasing worldwide. Whole-genome sequencing (WGS) now permits rapid identification of recombination events, a phenomenon that occurs frequently in GBS. Using WGS, we described that strain NGBS375, a capsular serotype V GBS isolate of sequence type (ST)297, has an ST1 genomic background but has acquired approximately 300 kbp of genetic material likely from an ST17 strain. Here, we examined the virulence of this strain in an in vivo model of GBS adult invasive infection...
August 5, 2016: Pathogens
Jun Hirai, Daisuke Sakanashi, Mao Hagihara, Shusaku Haranaga, Kohei Uechi, Hideo Kato, Hiroyuki Hamada, Naoya Nishiyama, Yusuke Koizumi, Hiroyuki Suematsu, Yuka Yamagishi, Jiro Fujita, Hiroshige Mikamo
Gene sequence analysis methods, including 16S rRNA identification, allows accurate identification of Streptococcus species, which include phenotypically closely related species that are difficult to differentiate using conventional chemical methods. We report a case of bacteremia due to Streptococcus tigurinus, identified by 16S rRNA, in a 72-year-old woman with gastrointestinal cancer and ascites. She was hospitalized to undergo elective tumor-related surgery. Five days prior to undergoing surgery, she developed a fever with no obvious source of infection...
July 23, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
S Desmet, J Maertens, K Bueselinck, K Lagrou
Infection is an important complication in patients with hematologic malignancies or solid tumors undergoing intensive cytotoxic chemotherapy. In only 20 to 30% of the febrile neutropenic episodes, an infectious agent is detected by conventional cultures. In this prospective study, the performance of broad-range PCR coupled with electrospray ionization time of flight mass spectrometry (PCR/ESI-MS) technology was compared to conventional blood cultures (BC) in a consecutive series of samples from high-risk hematology patients...
October 2016: Journal of Clinical Microbiology
Alfredo Tagarro, Patricia Bote, Aida Sánchez, Enrique Otheo, Juan-Carlos Sanz, David Sanz-Rosa
BACKGROUND: In the Region of Madrid, universal immunization with the 13-serotypes pneumococcal conjugate vaccine (PCV13) started in May 2010. In July 2012, public funding ceased. Vaccination coverage decreased from >95% to 82% in 2013 and to 67% in 2014. Our aim was to investigate the impact of PCV13 withdrawal from Madrid Region's universal immunization program on the incidence of complicated pneumococcal bacteremia. METHODS: We performed a multi-center retrospective cohort study, from 2009 to 2014...
July 18, 2016: Pediatric Infectious Disease Journal
T Halperin, H Levine, Z Korenman, S Burstein, R Amber, T Sela, L Valinsky
Beta-hemolytic group G streptococci (GGS) are increasingly recognized as a source of substantial morbidity, causing mild to severe sporadic infections as well as outbreaks. The purpose of this study was to determine the genetic diversity and antibiotic resistance of GGS in Israel in order to aid in prevention and control. A total of 325 GGS isolates were collected in Israel between 2007 and 2011 from three determined settings: (1) carriage (n = 60), an observational longitudinal carriage study in the IF, (2) non-invasive (n = 166), clinical sporadic and epidemic non-invasive cases in the IDF, and (3) invasive (n = 99) cases of bacteremia collected during this period in Israel from a similar age group, at the national Streptococcal Reference Center...
October 2016: European Journal of Clinical Microbiology & Infectious Diseases
Taeeun Kim, Sun In Hong, Se Yoon Park, Jiwon Jung, Yong Pil Chong, Sung-Han Kim, Sang-Oh Lee, Yang Soo Kim, Jun Hee Woo, Young-Suk Lim, Heungsup Sung, Mi-Na Kim, Sang-Ho Choi
Streptococcus pneumoniae is a well-known cause of spontaneous bacterial peritonitis (SBP) in cirrhotic patients. However, little information is available regarding clinical characteristics and outcomes of SBP caused by S. pneumoniae. It has been suggested that spontaneous pneumococcal peritonitis (SPP) often spreads hematogenously from concomitant pneumococcal pneumonia, and is associated with a higher rate of mortality.During the period between January 1997 and December 2013, 50 SPP cases were identified. These cases were then age/sex-matched with 100 patients with SBP due to causes other than S...
May 2016: Medicine (Baltimore)
Anna Rautanen, Matti Pirinen, Tara C Mills, Kirk A Rockett, Amy Strange, Anne W Ndungu, Vivek Naranbhai, James J Gilchrist, Céline Bellenguez, Colin Freeman, Gavin Band, Suzannah J Bumpstead, Sarah Edkins, Eleni Giannoulatou, Emma Gray, Serge Dronov, Sarah E Hunt, Cordelia Langford, Richard D Pearson, Zhan Su, Damjan Vukcevic, Alex W Macharia, Sophie Uyoga, Carolyne Ndila, Neema Mturi, Patricia Njuguna, Shebe Mohammed, James A Berkley, Isaiah Mwangi, Salim Mwarumba, Barnes S Kitsao, Brett S Lowe, Susan C Morpeth, Iqbal Khandwalla, Jenefer M Blackwell, Elvira Bramon, Matthew A Brown, Juan P Casas, Aiden Corvin, Audrey Duncanson, Janusz Jankowski, Hugh S Markus, Christopher G Mathew, Colin N A Palmer, Robert Plomin, Stephen J Sawcer, Richard C Trembath, Ananth C Viswanathan, Nicholas W Wood, Panos Deloukas, Leena Peltonen, Thomas N Williams, J Anthony G Scott, Stephen J Chapman, Peter Donnelly, Adrian V S Hill, Chris C A Spencer
Bacteremia (bacterial bloodstream infection) is a major cause of illness and death in sub-Saharan Africa but little is known about the role of human genetics in susceptibility. We conducted a genome-wide association study of bacteremia susceptibility in more than 5,000 Kenyan children as part of the Wellcome Trust Case Control Consortium 2 (WTCCC2). Both the blood-culture-proven bacteremia case subjects and healthy infants as controls were recruited from Kilifi, on the east coast of Kenya. Streptococcus pneumoniae is the most common cause of bacteremia in Kilifi and was thus the focus of this study...
June 2, 2016: American Journal of Human Genetics
Hiroyuki Suzuki, Ryota Hase, Yoshihito Otsuka, Naoto Hosokawa
OBJECTIVES: To investigate the characteristics of Streptococcus anginosus group (SAG) bacteremia in recent years, we conducted a retrospective cohort study and compared its findings with the data from previous studies. METHODS: All patients with positive blood cultures from May 2005 to September 2014 in a tertiary care center with 925 beds were included. RESULTS: There were 78 cases of SAG bacteremia (51 cases men; median age, 68 years) during the study period...
July 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Kim Oren Gradel, Stig Lønberg Nielsen, Court Pedersen, Jenny Dahl Knudsen, Christian Østergaard, Magnus Arpi, Thøger Gorm Jensen, Hans Jørn Kolmos, Mette Søgaard, Annmarie Touborg Lassen, Henrik Carl Schønheyder
OBJECTIVE Seasonal variation is a characteristic of many infectious diseases, but relatively little is known about determinants thereof. We studied the impact of place of acquisition and patient characteristics on seasonal variation of bacteremia caused by the 3 most common pathogens. DESIGN Seasonal variation analysis. METHODS In 3 Danish health regions (2.3 million total inhabitants), patients with bacteremia were identified from 2000 through 2011 using information from laboratory information systems. Analyses were confined to Escherichia coli, Staphylococcus aureus, and Streptococcus pneumoniae...
August 2016: Infection Control and Hospital Epidemiology
Ea S Marmolin, Gitte N Hartmeyer, Jens J Christensen, Xiaohui C Nielsen, Rimtas Dargis, Marianne N Skov, Elisa Knudsen, Michael Kemp, Ulrik S Justesen
DNA sequencing of the intergenic spacer (ITS) region was used to identify 53 blood culture isolates that had previously been designated to the bovis group streptococci and clinical data was collected retrospectively from patients' records using a standardized protocol. ITS sequencing identified 19 (35.8%) isolates as Streptococcus gallolyticus subsp. gallolyticus, 12 (22.6%) as S. gallolyticus subsp. pasteurianus, two (3.8%) as S. gallolyticus subsp. macedonicus, seven (13.2%) as S. infantarius subsp. infantarius, 12 (22...
June 2016: Diagnostic Microbiology and Infectious Disease
Nobuo Okahashi, Masanobu Nakata, Hirotaka Kuwata, Shigetada Kawabata
Streptococcus oralis, an oral commensal, belongs to the mitis group of streptococci and occasionally causes opportunistic infections, such as bacterial endocarditis and bacteremia. Recently, we found that the hydrogen peroxide (H2O2) produced by S. oralis is sufficient to kill human monocytes and epithelial cells, implying that streptococcal H2O2 is a cytotoxin. In the present study, we investigated whether streptococcal H2O2 impacts lysosomes, organelles of the intracellular digestive system, in relation to cell death...
July 2016: Infection and Immunity
George E Nelson, Tracy Pondo, Karrie-Ann Toews, Monica M Farley, Mary Lou Lindegren, Ruth Lynfield, Deborah Aragon, Shelley M Zansky, James P Watt, Paul R Cieslak, Kathy Angeles, Lee H Harrison, Susan Petit, Bernard Beall, Chris A Van Beneden
BACKGROUND: Invasive group A Streptococcus (GAS) infections are associated with significant morbidity and mortality rates. We report the epidemiology and trends of invasive GAS over 8 years of surveillance. METHODS: From January 2005 through December 2012, we collected data from the Centers for Disease Control and Prevention's Active Bacterial Core surveillance, a population-based network of 10 geographically diverse US sites (2012 population, 32.8 million). We defined invasive GAS as isolation of GAS from a normally sterile site or from a wound in a patient with necrotizing fasciitis (NF) or streptococcal toxic shock syndrome (STSS)...
August 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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