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https://www.readbyqxmd.com/read/29670766/corneal-debridement-combined-with-intrastromal-voriconazole-for-recalcitrant-fungal-keratitis
#1
Yajie Sun, Zhuo Sun, Yukai Chen, Guohua Deng
Background: To analyze the therapeutic effects of corneal debridement combined with intrastromal voriconazole in recalcitrant fungal keratitis. Methods: This is a retrospective study. Fourteen patients with recalcitrant fungal keratitis were treated by corneal debridement combined with intrastromal voriconazole (50  μ g/0.1 ml). This paper reviews and analyzes the patients' basic state, surgical intervention, medicinal treatment, and outcomes. Results: The mean sizes of infiltration and ulcer were (5...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29668589/atopic-keratoconjunctivitis-a-diagnostic-dilemma-a-case-report
#2
Aipeng Li, Shang Li, Fang Ruan, Ying Jie
RATIONALE: Atopic keratoconjunctivitis (AKC) remains a difficult diagnosis despite advances in imaging technologies. This is a case study of the diagnostic and treatment course for a patient with AKC. PATIENT CONCERNS: A 15-year-old male complained of progressively increasing pain, redness, watering and blurred vision in the right eye. The medical history showed that the patient suffered from itching on the hands, knees, neck and the eye skin one year before the onset of initial symptoms in the affected eye...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29656541/a-novel-herpesvirus-associated-with-chronic-superficial-keratitis-and-proliferative-conjunctivitis-in-a-great-horned-owl-bubo-virginianus
#3
Molly D Gleeson, Bret A Moore, Sydney G Edwards, Sarah Stevens, April L Childress, James F X Wellehan, Jessica Robertson, Christopher J Murphy, Michelle G Hawkins, Joanne Paul-Murphy
An adult great-horned owl (Bubo virginianus; GHOW) presented with a history of recurrent corneal ulceration of the right eye (OD). Findings included ulcerative superficial keratitis, proliferative conjunctivitis, and iris pigmentary changes. The ulcer was initially nonresponsive to medical therapy, but showed rapid and appropriate healing following diamond burr debridement. Proliferative conjunctivitis markedly improved following topical antiviral therapy with cidofovir 1%, interferon alpha 2B ophthalmic solutions, and oral l-lysine...
April 14, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29651949/nerve-growth-factor-early-studies-and-recent-clinical-trials
#4
Maria Luisa Rocco, Marzia Soligo, Luigi Manni, Luigi Aloe
Since its discovery, nerve growth factor (NGF) has long occupied a critical role in developmental and adult neurobiology for its many important regulatory functions on the survival, growth and differentiation of nerve cells in the peripheral and central nervous system. NGF is the first discovered member of a family of neurotrophic factors, collectively indicated as neurotrophins, (which include brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin 4/5). NGF was discovered for its action on the survival and differentiation of selected populations of peripheral neurons...
April 11, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29643799/optical-coherence-tomography-examination-of-the-anterior-segment-in-a-case-of-corneal-perforation-and-lens-trauma-by-chestnut-burr
#5
Takashi Ono, Yosai Mori, Ryohei Nejima, Takuya Iwasaki, Shiro Amano, Kazunori Miyata
Chestnut burrs, the thorny encapsulation of chestnut fruit, can sometimes cause corneal injuries and ulceration, with poor prognoses. We report a case of corneal perforation and damaged anterior lens capsule due to a chestnut burr, using anterior segment optical coherence tomography (AS-OCT). A 67-year-old woman with a chestnut burr injury in her right eye was referred to our hospital. Her right best-corrected visual acuity (BCVA) was 0.8. Slit-lamp examination and AS-OCT showed perforation involving the endothelial layer at the center of the cornea...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29642830/-a-new-strategy-for-enhancing-acanthamoebicidal-activity-with-synthesis-of-nanoflower-of-laurocerausus-officinalis-roemer-cherry-laurel-fruit-extracts
#6
Ayşe Baldemir, Ülkü Karaman, Sadi Yusufbeyoğlu, Ayşe Eken, Nilay Ildız, Selen İlgün, Cemil Çolak, Gamze Kaçmaz, İsmail Öçsoy, Soner Çankaya
Pathogenic Acanthamoeba species often cause infection known as Acanthamoeba keratitis among people who use contact lenses. It is a type of infection that can result in corneal ulceration, visual loss or even blindness, if not treated. There are various therapeutic options available in the treatment of Acanthamoeba infections but they are usually tough treatments with limited efficacy. For instance, hydrogen peroxide (H2 O2 ) is a commonly used contact lens disinfectant which is effective against Acanthamoeba but it is toxic to the cornea...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29622703/immune-stromal-keratitis-a-rare-ocular-presentation-of-tuberculosis
#7
Deepali Singhal, Prafulla Kumar Maharana, Namrata Sharma, Jeewan S Titiyal
An 11-year-old female patient presented with diminution of vision in both the eyes for the last 4 days. She had redness, watering and photophobia for the past 11 days. Slit lamp examination revealed multiple disc-shaped corneal stromal infiltrates with an overlying epithelial defect and hypopyon in both the eyes. A provisional diagnosis of infective keratitis was made. The patient was started on empirical antimicrobial therapy. However, no improvement was noted over the next 72 hours. Microbiological examination of the corneal scraping from both the eyes was negative...
April 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29610174/recalcitrant-atopic-keratoconjunctivitis-in-children-a-case-report-and-literature-review
#8
Jing Li, Xiaohui Luo, Hongmin Ke, Lingyi Liang
Atopic keratoconjunctivitis (AKC) is the most severe type of allergic conjunctivitis and may eventually lead to blindness. Although AKC is reported to be more prevalent in adults, we report a child with AKC whose clinical characteristics were not inconsistent with those typically seen in adult patients with AKC, and who was refractory to traditional topical anti-inflammatory and immunosuppressant therapies. An 11-year-old boy presented with a 3-month history of ocular redness and itching and decreased vision for a week in both eyes...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29594157/use-of-nasotracheal-intubation-during-general-anesthesia-in-two-ponies-with-tracheal-collapse
#9
Keila K Ida, Aurélie Sauvage, Alexandra Gougnard, Magda Grauwels, Didier Serteyn, Charlotte Sandersen
Ponies with tracheal collapse may have an increased anesthetic risk due to airway obstruction during induction and recovery. To our knowledge, there are no anesthetic descriptions of these patients, despite a reported 5.6% incidence and 77% mortality rate. Two Shetland ponies with tracheal collapse, a 12-year-old male (pony 1) and a 27-year-old female (pony 2), were referred for right eye enucleation due to a perforating corneal ulcer and severe recurrent uveitis, respectively. Pony 1 was stressed, had lung stridor and hyperthermia, and developed inspiratory dyspnea with handling...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29587979/keratophakia-with-autograft-aided-by-a-femtosecond-laser-one-year-follow-up
#10
Claudio Orlich
Autologous tissue from correction of myopia with small-incision lenticule extraction in 1 eye of a patient was used to enhance corneal curvature in the contralateral eye, in which a corneal ulcer had flattened the cornea. Regularization of the corneal tomography was achieved, improving the visual quality and visual capacity of the patient.
February 2018: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29580975/argon-cold-plasma-a-novel-tool-to-treat-therapy-resistant-corneal-infections
#11
Helena H Reitberger, Marta Czugala, Catherine Chow, Andreas Mohr, Andreas Burkovski, Anja K Gruenert, Renate Schoenebeck, Thomas A Fuchsluger
PURPOSE: To test whether therapy-resistant corneal infections can be successfully treated with argon cold plasma to reduce or eliminate pathogen microorganisms without affecting corneal cell viability. DESIGN: First-in-man case series and experimental study. METHODS: Cold plasma effects on viability of primary human corneal limbal epithelial cells were studied using exposure times from 0.5 to 10 minutes (metabolic activity, oxidative stress, apoptosis)...
March 23, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29580152/epidemiology-risk-factors-and-clinical-outcomes-in-severe-microbial-keratitis-in-south-india
#12
Jaya Devi Chidambaram, Namperumalsamy Venkatesh Prajna, Palepu Srikanthi, Shruti Lanjewar, Manisha Shah, Shanmugam Elakkiya, Prajna Lalitha, Matthew J Burton
PURPOSE: Here, we report risk factors associated with outcome in severe bacterial keratitis (BK), fungal keratitis (FK), and Acanthamoeba keratitis (AK) in India. METHODS: Prospective observational cohort study conducted in Aravind Eye Hospital, India. Adults presenting with severe microbial keratitis (MK) were enrolled (size ≥3 mm) and followed to 21 days post-enrolment. Ulcer clinical features were recorded at presentation. Outcomes by final visit were classified as good (completely healed or reduced infiltrate size) or poor (enlarged infiltrate size, perforated, or surgery performed)...
March 26, 2018: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29577102/a-case-with-corneal-perforation-due-to-bacterial-concretion-derived-from-lacrimal-canaliculitis
#13
Sho Ishikawa, Naoko Kato
Purpose: To report a case with corneal perforation, presumably due to ocular cicatricial pemphigoid (OCP) and bacterial concretion derived from lacrimal canaliculitis. Observations: A patient with OCP demonstrated adherence of concretion to the cornea of her right eye. She also demonstrated canaliculitis in this eye. We removed a whitish precipitate from the bottom of the corneal ulcer. When we flushed her lacrimal pathway, a marked amount of bacterial concretion and dense mucosa were refluxed from both puncta on the right side...
March 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29566537/treatment-with-platelet-rich-plasma-of-surgically-related-dormant-corneal-ulcers
#14
Jorge L Alio, Alejandra E Rodriguez, Pablo De Arriba, Sandra Gisbert, Ahmed A Abdelghany
PURPOSE: To assess the effectiveness of autologous platelet-rich plasma for the treatment of dormant corneal ulcers secondary to corneal surgery and unresponsive to conventional treatment. SETTING: VISSUM, Ophthalmology Institute of Alicante, Alicante, Spain. DESIGN: Prospective nonrandomized, observational consecutive study. METHODS: A total of 44 eyes of 28 patients with dormant corneal ulcers secondary to corneal surgery were included in a prospective study and treated with autologous platelet-rich plasma during 6 weeks...
March 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29556704/factors-associated-with-severe-dry-eye-in-primary-sj%C3%A3-gren-s-syndrome-diagnosed-patients
#15
Mónica Fernandez Castro, Carlos Sánchez-Piedra, Jose Luis Andreu, Víctor Martínez Taboada, Alejandro Olivé, Jose Rosas
INTRODUCTION: Primary Sjögren's syndrome (pSS) is an autoimmune disease, characterized by lymphocytic infiltration of exocrine glands and other organs, resulting in dry eye, dry mouth and extraglandular systemic findings. OBJECTIVE: To explore the association of severe or very severe dry eye with extraocular involvement in patients diagnosed with primary Sjögren's syndrome. METHODS: SJOGRENSER registry is a multicenter cross-sectional study of pSS patients...
March 20, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29554009/case-report-acanthamoeba-keratitis-management-in-a-first-trimester-pregnant-patient
#16
Francisco de Borja Domínguez-Serrano, Manuel Caro-Magdaleno, Rafael Perea-Pérez, Enrique Rodríguez-de-la-Rúa, Jesús Montero-Iruzubieta
SIGNIFICANCE: Lacrimal punctal plugs may prevent the teratogenicity of the treatment used in infectious keratitis. Its use should be strongly considered in these cases. PURPOSE: We present the case of a 7-week pregnant patient with Acanthamoeba keratitis. CASE REPORT: The patient was a contact lens user with photophobia, redness, and intense pain in the right eye that started 2 weeks earlier. Corrected visual acuity was 20/63 (0.5 logMAR)...
March 16, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29550185/in-vivo-confocal-microscopy-cellular-features-of-host-and-organism-in-bacterial-fungal-and-acanthamoeba-keratitis
#17
Jaya D Chidambaram, Namperumalsamy V Prajna, Srikanthi Palepu, Shruti Lanjewar, Manisha Shah, Shanmugam Elakkiya, David Macleod, Prajna Lalitha, Matthew J Burton
PURPOSE: To determine cellular features of fungal (FK), Acanthamoeba (AK) and bacterial keratitis (BK) using HRT3 in vivo confocal microscopy (IVCM). DESIGN: Prospective observational cross-sectional study. METHODS: Eligible participants were adults with microbiologically-positive FK, AK or BK, of size ≥3mm attending Aravind Eye Hospital from Feb 2012 to Feb 2013. EXCLUSION CRITERIA: descemetocele, perforation. At presentation, IVCM imaging was performed, then corneal scrapes obtained for culture/light microscopy...
March 14, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29543218/-surgery-treatment-of-purulent-corneal-ulcers-associated-with-neuroparalytic-keratitis
#18
Evg A Kasparova, O I Sobkova, E A Kasparova, A A Kasparov
OBJECTIVE: The study objective was to develop a method for surgical treatment of advanced purulent corneal ulcer in the setting of neuroparalytic keratitis developed after acoustic neuroma removal and strokes. MATERIAL AND METHODS: The study included 12 patients (13 eyes). All patients underwent single-step keratoplasty, conjunctival autografting, and partial permanent tarsorrhaphy. RESULTS: The eye as an organ was spared in 100% of cases; vision was spared in 50% of cases and improved, from 0...
2018: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/29520917/the-use-of-hyaluronic-acid-subdermal-filler-for-entropion-in-canines-and-felines-40-cases
#19
Jessica E McDonald, Amy M Knollinger
PURPOSE: To evaluate the use of hyaluronic acid (HA) subdermal filler in canines and felines for entropion. METHODS: Complete ophthalmologic examination was performed by a board-certified veterinary ophthalmologist or ABVO-approved resident. Each case was characterized as primary, secondary, spastic or cicatricial entropion. HA subdermal filler, specifically Restylane® and Restylane Silk® , were utilized in dogs and cats, respectively. Subdermal injection was performed 1-2 mm from the eyelid margin in the affected area until normal eyelid conformation was achieved...
March 9, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29517701/evaluation-of-a-new-matrix-regenerating-agent-in-patients-with-sj%C3%A3-gren-syndrome-and-superficial-ulcerative-keratitis-resistant-to-conventional-therapy-a-report-of-3-cases
#20
Franck Fajnkuchen, Denis Barritault, Audrey Giocanti-Aurégan
RATIONALE: Sjögren syndrome (SS) is frequently associated with ulcerative keratitis, which is difficult to treat due to lacrimal tear deficiency and inflammation of the ocular surface. PATIENT CONCERNS: We report the successful additive effect of a matrix regenerating agent (RGTA, Cacicol) in SS patients with severe superficial ulcerative keratitis resistant to conventional therapy. DIAGNOSES: Retrospective, noncomparative case series of patients with primary or secondary SS associated with chronic diffuse keratitis...
March 2018: Medicine (Baltimore)
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