Refaat A Eid, Mahmoud A Alkhateeb, Attalla Farag El-Kott, Samy M Eleawa, Mohamed Samir Ahmed Zaki, Sultan Abdullah Alaboodi, Abd Al-Rahman Salem Al-Shudiefat, Hussain Aldera, Nada Mohammad Alnamar, Mohammed Alassiri, Mohammad A Khalil
This study compared the effect of low-fat diet (LFD) and high-fat diet rich in corn oil (HFD-CO) on left ventricular (LV) fibrosis in rats and examined their effect of angiotensin II (ANG II), JAK/STAT, and TGF-1β/smad3 pathways. As compared to LFD which didn't affect any of the measured parameters, HFD-CO-induced type 2 diabetes phenotype and increased LV collagen synthesis. Mechanistically, it increased LV levels of ROS, ANG II, ACE, IL-6, s-IL-6Rα, TGF-β1, Smad-3, and activities of JAK1/2 and STAT1/3...
August 2019: Journal of Food Biochemistry