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https://www.readbyqxmd.com/read/28705409/clinical-benefit-and-risk-of-death-with-endocrine-therapy-in-ovarian-cancer-a-comprehensive-review-and-meta-analysis
#1
Laura Paleari, Sara Gandini, Nicoletta Provinciali, Matteo Puntoni, Nicoletta Colombo, Andrea DeCensi
BACKGROUND: Steroid hormones promote epithelial ovarian cancer (EOC) growth and their receptor expression is associated with disease outcome. Hormone therapy is frequently used in pretreated EOC, but the magnitude of activity overall and by specific agents or tumor characteristics is unknown. METHODS: Clinical Benefit Rates (CBR) and deaths from clinical trials of endocrine agents were meta-analyzed. Summary estimates of CBR (SCBR) and Odd Ratio for death (SOR) were calculated according with type of drug, ER and PgR status, platinum resistance, line of therapy, tumor grade and tamoxifen dose...
July 10, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28700020/a-meta-analysis-of-circulating-microvesicles-in-patients-with-myocardial-infarction
#2
Zhida Wang, Wang Cai, Shaolan Hu, Yufei Xia, Yao Wang, Qi Zhang, Liming Chen
Background: Cell-derived microvesicles (MVs) are vesicles released from activated or apoptotic cells. However, the levels of MVs in myocardial infarction have been found inconsistent in researches. Objective: To assess the association between MVs and myocardial infarction by conducting a meta-analysis. Methods: A systematic literature search on PubMed, Embase, Cochran, Google Scholar electronic database was conducted. Comparison of the MVs levels between myocardial infarction patients and healthy persons were included in our study...
July 10, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28696414/pharmacogenetics-of-oral-antidiabetes-drugs-evidence-for-diverse-signals-at-the-irs1-locus
#3
S Prudente, R Di Paola, S Pezzilli, M Garofolo, O Lamacchia, T Filardi, G C Mannino, L Mercuri, F Alberico, M G Scarale, G Sesti, S Morano, G Penno, M Cignarelli, M Copetti, V Trischitta
To investigate the role of IRS1 locus on failure to oral antidiabetes drugs (OADs) we genotyped single-nucleotide polymorphisms (SNPs), rs2943641, rs7578326 (tagging all SNPs genome-wide associated with type 2 diabetes (T2D) and related traits at this locus) and rs1801278 (that is, the loss-of-function IRS1 G972R amino acid substitution) in 2662 patients with T2D. Although no association with OAD failure was observed for rs2943641 and rs7578326 SNPs (odds ratio (OR): 1.04, 95% confidence interval (CI): 0.93-1...
July 11, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/28692937/phthalate-esters-and-childhood-asthma-a-systematic-review-and-congener-specific-meta-analysis
#4
Ming-Chieh Li, Chi-Hsien Chen, Yue Leon Guo
INTRODUCTION: Exposure to phthalate esters (PAEs) has been associated with childhood asthma, but the congener-specific effects of PAEs on childhood asthma were unclear. We aimed to systematically review and meta-analyze observational studies on the associations between specific effects of PAEs and the risk of childhood asthma. MATERIAL AND METHODS: Relevant studies were identified by searching three databases up to October 20, 2016. The reference lists of the retrieved articles were also reviewed...
July 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28692782/a-comparison-of-bivariate-multivariate-random-effects-and-poisson-correlated-gamma-frailty-models-to-meta-analyze-individual-patient-data-of-ordinal-scale-diagnostic-tests
#5
Gabrielle Simoneau, Brooke Levis, Pim Cuijpers, John P A Ioannidis, Scott B Patten, Ian Shrier, Charles H Bombardier, Flavia de Lima Osório, Jesse R Fann, Dwenda Gjerdingen, Femke Lamers, Manote Lotrakul, Bernd Löwe, Juwita Shaaban, Lesley Stafford, Henk C P M van Weert, Mary A Whooley, Karin A Wittkampf, Albert S Yeung, Brett D Thombs, Andrea Benedetti
Individual patient data (IPD) meta-analyses are increasingly common in the literature. In the context of estimating the diagnostic accuracy of ordinal or semi-continuous scale tests, sensitivity and specificity are often reported for a given threshold or a small set of thresholds, and a meta-analysis is conducted via a bivariate approach to account for their correlation. When IPD are available, sensitivity and specificity can be pooled for every possible threshold. Our objective was to compare the bivariate approach, which can be applied separately at every threshold, to two multivariate methods: the ordinal multivariate random-effects model and the Poisson correlated gamma-frailty model...
July 10, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/28692439/lipid-emulsion-in-local-anesthetic-toxicity
#6
Martyn Harvey, Grant Cave
PURPOSE OF REVIEW: Enthusiasm for regional anesthesia has been driven by multimodal benefits to patient outcomes. Despite widespread awareness and improved techniques (including the increasing use of ultrasound guidance for block placement), intravascular sequestration and the attendant risk of local anesthetic systemic toxicity (LAST) remains. Intravenous lipid emulsion (ILE) for the treatment of LAST has been endorsed by anesthetic regulatory societies on the basis of animal study and human case report data...
July 7, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28691506/the-effect-of-music-therapy-on-cognitive-functions-in-patients-with-dementia-a-systematic-review-and-meta-analysis
#7
Laura Fusar-Poli, Łucja Bieleninik, Natascia Brondino, Xi-Jing Chen, Christian Gold
OBJECTIVES: The aim of the present study was to meta-analyze the effect of music therapy (MT) on cognitive functions in patients with dementia. METHOD: A systematic literature search was performed in Medline, PsycINFO, Embase, CINAHL and RILM up to 8 September 2016. We included all randomized controlled trials that compared MT with standard care, or other non-musical types of intervention, evaluating cognitive outcomes in patients with dementia. Outcomes included global cognition, complex attention, executive function, learning and memory, language, and perceptual-motor skills...
July 10, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28691307/socio-sexual-functioning-in-autism-spectrum-disorder-a-systematic-review-and-meta-analyses-of-existing-literature
#8
Grace I P Hancock, Mark A Stokes, Gary B Mesibov
Socio-sexual functioning encompasses an individual's interests, behaviors, and knowledge with respect to sexual, romantic, and social aspects of life. An individual's understanding of these domains is developed through a range of informal and formal avenues of sexual health education. The current model demonstrated this and proposed that, compared to typically developing individuals, those with ASD develop socio-sexual functioning differently due to having less peer engagement, less relationship experience, more parental guidance, greater use of online materials, receive less school-based sexual health education, and more support from wellbeing services...
July 10, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28688758/-european-birth-cohorts-early-life-exposure-to-microorganisms-and-health-impact
#9
REVIEW
S Rocchi, G Reboux
In recent years, many birth cohorts have been initiated in Europe, to assess the early life microbiological exposure of children in the indoor environment and better understanding the different effects (adverse/protectors) on health. The results of 12 European cohorts, with different methodologies for exposure and allergic risk assessment are summarized in this review. Four meta-analyzes of cohort are presented too. Microbiological researches in indoor environment seem to turn to a metrology of microbiological exposure, but few studies provide real quantitative data...
July 5, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28688713/obesity-and-the-risk-of-systemic-lupus-erythematosus-among-women-in-the-nurses-health-studies
#10
Sara K Tedeschi, Medha Barbhaiya, Susan Malspeis, Bing Lu, Jeffrey A Sparks, Elizabeth W Karlson, Walter Willett, Karen H Costenbader
BACKGROUND: Obesity is increasingly prevalent and related to increased risk of several autoimmune diseases, likely via generation of inflammatory adipokines. Prior studies have not evaluated obesity in relation to systemic lupus erythematosus (SLE) risk. We prospectively evaluated whether obesity was associated with increased SLE risk among women in the U.S. Nurses' Health Study cohorts. METHODS: We conducted a prospective cohort study among 238,130 women in the Nurses' Health Studies (NHS, 1976-2012; NHSII, 1989-2013)...
May 25, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28668336/the-nod2-smoking-interaction-in-crohn-s-disease-is-likely-specific-to-the-1007fs-mutation-and-may-be-explained-by-age-at-diagnosis-a-meta-analysis-and-case-only-study
#11
M Ellen Kuenzig, Jeff Yim, Stephanie Coward, Bertus Eksteen, Cynthia H Seow, Cheryl Barnabe, Herman W Barkema, Mark S Silverberg, Peter L Lakatos, Paul L Beck, Richard Fedorak, Levinus A Dieleman, Karen Madsen, Remo Panaccione, Subrata Ghosh, Gilaad G Kaplan
BACKGROUND: NOD2 and smoking are risk factors for Crohn's disease. We meta-analyzed NOD2-smoking interactions in Crohn's disease (Phase 1), then explored the effect of age at diagnosis on NOD2-smoking interactions (Phase 2). METHODS: Phase 1: MEDLINE and EMBASE were searched for studies (n=18) providing data on NOD2 and smoking in Crohn's disease. NOD2-smoking interactions were estimated using odds ratios (ORs) and 95% confidence intervals (CIs) calculated using random effects models...
June 16, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28668296/igg-glycan-patterns-are-associated-with-type-2-diabetes-in-independent-european-populations
#12
Roosmarijn F H Lemmers, Marija Vilaj, Daniel Urda, Felix Agakov, Mirna Šimurina, Lucija Klaric, Igor Rudan, Harry Campbell, Caroline Hayward, Jim F Wilson, Aloysius G Lieverse, Olga Gornik, Eric J G Sijbrands, Gordan Lauc, Mandy van Hoek
BACKGROUND: Type 2 diabetes results from interplay between genetic and acquired factors. Glycans on proteins reflect genetic, metabolic and environmental factors. However, associations of IgG glycans with type 2 diabetes have not been described. We compared IgG N-glycan patterns in type 2 diabetes with healthy subjects. METHODS: In the DiaGene study, a population-based case-control study, (1886 cases and 854 controls) 58 IgG glycan traits were analyzed. Findings were replicated in the population-based CROATIA-Korcula-CROATIA-Vis-ORCADES studies (162 cases and 3162 controls), and meta-analyzed...
June 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28659741/impact-of-palm-olein-in-infant-formulas-on-stool-consistency-and-frequency-a-meta-analysis-of-randomized-clinical-trials
#13
John B Lasekan, Deborah S Hustead, Marc Masor, Robert Murray
Background: Meta-analysis studies have documented that palm olein (PALM) predominant formulas reduce calcium and fat absorption, and bone mineralization in infants, but none have been documented for stool consistency and frequency. Objective: The study objective was to conduct a meta-analysis of published randomized clinical trials (RCTs) on the effect of PALM-based formulas on stool consistency and frequency in infants. Design: A literature search was conducted in BIOSIS Previews®, Embase®, Embase® Alert, MEDLINE® and Cochrane databases...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28658128/association-of-wdr36-polymorphisms-with-primary-open-angle-glaucoma-a-systematic-review-and-meta-analysis
#14
REVIEW
Ke Liu, Wenling He, Jun Zhao, Yingxia Zeng, Hongbo Cheng
BACKGROUND: The association of the WDR36 gene with glaucoma has been controversial in the literature. We therefore conducted a systematic review and meta-analysis to assess the association of all reported common polymorphisms in WDR36 with primary open angle glaucoma (POAG) and its subtypes: high tension glaucoma (HTG) and normal tension glaucoma (NTG). METHODS: Publications in PUBMED and EMBASE databases up to March 9, 2016 were searched for case-control association studies of WDR36 with POAG, HTG, and/or NTG...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28658120/the-effect-of-platelet-rich-plasma-on-reducing-blood-loss-after-total-knee-arthroplasty-a-systematic-review-and-meta-analysis
#15
REVIEW
Jinhui Ma, Jiale Sun, Wanshou Guo, Zirong Li, Bailiang Wang, Weiguo Wang
BACKGROUND: Efficacy and safety of platelet-rich plasma (PRP) compared with control for preventing postoperative bleeding after total knee arthroplasty (TKA) is controversial. We performed a meta-analysis of randomized controlled trials (RCTs) to determine whether PRP might reduce blood loss and improve function following TKA. METHODS: PubMed, Medline, Embase, Web of Science, and the Cochrane Library were searched to identify RCTs comparing PRP with control for patients undergoing unilateral TKA...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28655354/perioperative-systemic-steroid-for-rapid-recovery-in-total-knee-and-hip-arthroplasty-a-systematic-review-and-meta-analysis-of-randomized-trials
#16
REVIEW
Chen Yue, Rong Wei, Youwen Liu
BACKGROUND: Perioperative systemic steroid administration for rapid recovery in total knee and hip arthroplasty (TKA/THA) is an important and controversial topic. We conducted this systematic review and meta-analysis to evaluate the overall benefits and harms of perioperative systemic steroid in patients undergoing TKA and THA. METHODS: A comprehensive search was performed on PubMed, OVID, and Web of Science databases, and a systematic approach was carried out starting from the PRISMA recommendations...
June 27, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28652875/contemporary-cost-consequence-analysis-of-blue-light-cystoscopy-with-hexaminolevulinate-in-non-muscle-invasive-bladder-cancer
#17
Zachary Klaassen, Kathy Li, Wassim Kassouf, Peter C Black, Alice Dragomir, Girish S Kulkarni
INTRODUCTION: Previous studies have suggested cost-savings using blue light cystoscopy (BLC) with hexaminolevulinate (HAL) compared to white light cystoscopy (WLC) during transurethral resection of bladder tumour (TURBT) for non-muscle-invasive bladder cancer (NMIBC), secondary to improvements in recurrence and progression rates; however, these studies have used 'best case scenario' recurrence rate probabilities, thus decreasing generalizability of the findings. The objective of this study was to perform a contemporary cost-effectiveness assessment of BLC compared to WLC at the time of TURBT...
June 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28648791/drug-eluting-stents-versus-control-therapy-in-the-infrapopliteal-disease-a-meta-analysis-of-eight-randomized-controlled-trials-and-two-cohort-studies
#18
REVIEW
Xiaochun Liu, Guofu Zheng, Song Wen
BACKGROUD: Drug-eluting stents (DES) have been proposed for the treatment of infrapopliteal arteries disease. However, the long-term clinical impact of DES treatment in the vascular territory still remains uncertain. METHODS AND RESULTS: Pubmed, Embase, Cochrane data, CNKI and Wanfang Data were searched until December 20, 2016 for eligible studies according to identical strategies. Additional data were manually retrieved. STATA ver. 12.0 software were used to Meta-analyze the efficacies of DES and control treatment (BMS or PTA) for infrapopliteal arteries disease...
June 23, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28647763/decompression-plus-fusion-versus-decompression-alone-for-degenerative-lumbar-spondylolisthesis-a-systematic-review-and-meta-analysis
#19
REVIEW
Hai-Feng Liang, Shu-Hao Liu, Zi-Xian Chen, Qin-Ming Fei
PURPOSE: To compare the clinical effectiveness of decompression plus fusion and decompression alone for patients with degenerative lumbar spondylolisthesis, a systematic review and meta-analysis of all available evidence was performed. METHODS: A search of the literature was conducted on PubMed/MEDLINE, EMBASE, and the Cochrane Collaboration Library. Relevant studies comparing decompression plus fusion and decompression alone were selected according to eligibility criteria...
June 24, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28639505/rationale-and-design-of-the-multiethnic-pharmacogenomics-in-childhood-asthma-consortium
#20
Niloufar Farzan, Susanne J Vijverberg, Anand K Andiappan, Lambang Arianto, Vojko Berce, Natalia Blanca-López, Hans Bisgaard, Klaus Bønnelykke, Esteban G Burchard, Paloma Campo, Glorisa Canino, Bruce Carleton, Juan C Celedón, Fook Tim Chew, Wen Chin Chiang, Michelle M Cloutier, Denis Daley, Herman T Den Dekker, F Nicole Dijk, Liesbeth Duijts, Carlos Flores, Erick Forno, Daniel B Hawcutt, Natalia Hernandez-Pacheco, Johan C de Jongste, Michael Kabesch, Gerard H Koppelman, Vangelis G Manolopoulos, Erik Melén, Somnath Mukhopadhyay, Sara Nilsson, Colin N Palmer, Maria Pino-Yanes, Munir Pirmohamed, Uros Potočnki, Jan A Raaijmakers, Katja Repnik, Maximilian Schieck, Yang Yie Sio, Rosalind L Smyth, Csaba Szalai, Kelan G Tantisira, Steve Turner, Marc P van der Schee, Katia M Verhamme, Anke H Maitland-van der Zee
AIM: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium. MATERIALS & METHODS: Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questionnaire. RESULTS: A total of 21 studies, including 14,227 children/young persons (58% male), from 12 different countries are currently enrolled in the PiCA consortium...
July 2017: Pharmacogenomics
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