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https://www.readbyqxmd.com/read/29146048/cerebellar-volume-in-autism-literature-meta-analysis-and-analysis-of-the-autism-brain%C3%A2-imaging-data-exchange-cohort
#1
Nicolas Traut, Anita Beggiato, Thomas Bourgeron, Richard Delorme, Laure Rondi-Reig, Anne-Lise Paradis, Roberto Toro
BACKGROUND: The neuroanatomical bases of autism spectrum disorder remain largely unknown. Among the most widely discussed candidate endophenotypes, differences in cerebellar volume have been often reported as statistically significant. METHODS: We aimed at objectifying this possible alteration by performing a systematic meta-analysis of the literature and an analysis of the ABIDE (Autism Brain Imaging Data Exchange) cohort. Our meta-analysis sought to determine a combined effect size of autism spectrum disorder diagnosis on different measures of the cerebellar anatomy as well as the effect of possible factors of variability across studies...
October 10, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29145043/diagnostic-accuracy-of-magnetic-resonance-imaging-in-post-traumatic-brachial-plexus-injuries-a-systematic-review
#2
REVIEW
Helen K B Fuzari, Armèle Dornelas de Andrade, Clarice F Vilar, Larissa B Sayão, Paula R B Diniz, Fernando H Souza, Daniella A de Oliveira
Computed Tomographic Myelography (CTM) is a gold-standard imaging test for evaluating the brachial plexus and has been used for a long time. Another imaging test more recently used is Magnetic Resonance imaging (MRI), which is also part of the plexus evaluation. The purpose of this study was to determine the accuracy of MRI in diagnosing post-traumatic injuries of the brachial plexus. We conducted a Systematic Review with cross-sectional studies of diagnostic accuracy. Studies with populations presenting post-traumatic brachial plexus injury, over 16 years old, both genders, and examined by CT Myelography and MRI were evaluated...
November 11, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29140521/prevalence-of-catatonia-and-its-moderators-in-clinical-samples-results-from-a-meta-analysis-and-meta-regression-analysis
#3
Marco Solmi, G Giorgio Pigato, Beatrice Roiter, Argentina Guaglianone, Luca Martini, Michele Fornaro, Francesco Monaco, Andrè F Carvalho, Brendon Stubbs, Nicola Veronese, Christoph U Correll
Catatonia is an independent syndrome that co-occurs with several mental and medical conditions. We performed a systematic literature review in PubMed/Scopus until February 2017 and meta-analyzed studies reporting catatonia prevalence. Across 74 studies (cross-sectional = 32, longitudinal = 26, retrospective = 16) providing data collected from 1935 to 2017 across all continents, mean catatonia prevalence was 9.0% (k = 80, n = 110764; 95% CI = 6.9-11.7, I2 = 98%, publication bias P < .01), decreasing to 7...
November 13, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29134444/association-between-restless-legs-syndrome-and-hypertension-a-meta-analysis-of-nine-population-based-studies
#4
Yaoyao Shen, Hailing Liu, Tingmin Dai, Yanqin Guan, Jianglong Tu, Hongbing Nie
Previous population-based studies evaluating the association between restless legs syndrome (RLS) and cardiovascular risk factors have showed inconsistent results, especially for the relationship between RLS and hypertension. We, therefore, aimed to meta-analyze to assess the association between RLS and hypertension. PubMed and Embase databases were systematically searched to identify eligible studies. Nine population-based cross-sectional studies were selected for inclusion, involving 102,408 individuals. Overall, the prevalence of hypertension in RLS subjects was higher than those without RLS (OR = 1...
November 13, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29129318/does-childhood-trauma-moderate-polygenic-risk-for-depression-a-meta-analysis-of-5765-subjects-from-the-psychiatric-genomics-consortium
#5
Wouter J Peyrot, Sandra Van der Auwera, Yuri Milaneschi, Conor V Dolan, Pamela A F Madden, Patrick F Sullivan, Jana Strohmaier, Stephan Ripke, Marcella Rietschel, Michel G Nivard, Niamh Mullins, Grant W Montgomery, Anjali K Henders, Andrew C Heat, Helen L Fisher, Erin C Dunn, Enda M Byrne, Tracy A Air, Bernhard T Baune, Gerome Breen, Douglas F Levinson, Cathryn M Lewis, Nick G Martin, Elliot N Nelson, Dorret I Boomsma, Hans J Grabe, Naomi R Wray, Brenda W J H Penninx
BACKGROUND: The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. This study aims to meta-analyze MDD-PRS × CT interaction results across these two and other cohorts, while applying more accurate PRSs based on a larger discovery sample...
September 21, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29129233/low-fermentable-oligo-di-mono-saccharides-and-polyol-diet-in-the-treatment-of-irritable-bowel-syndrome-a-systematic-review-and-meta-analysis
#6
Dania Schumann, Petra Klose, Romy Lauche, Gustav Dobos, Jost Langhorst, Holger Cramer
OBJECTIVES: The aim of this review was to systematically assess and meta-analyze the effects of a low fermentable, oligo-, di-, mono-saccharides and polyol (FODMAP) diet (LFD) on the severity of symptoms, quality of life, and safety in patients with irritable bowel syndrome (IBS). METHODS: The MEDLINE/PubMed, Scopus, and Cochrane Library databases were screened through January 19, 2016. Randomized controlled trials (RCTs) that compared LFD to other diets were included if they assessed symptoms of IBS or abdominal pain in patients with IBS...
January 2018: Nutrition
https://www.readbyqxmd.com/read/29129021/the-effect-of-natural-or-simulated-altitude-training-on-high-intensity-intermittent-running-performance-in-team-sport-athletes-a-meta-analysis
#7
REVIEW
Michael J Hamlin, Catherine A Lizamore, Will G Hopkins
BACKGROUND: While adaptation to hypoxia at natural or simulated altitude has long been used with endurance athletes, it has only recently gained popularity for team-sport athletes. OBJECTIVE: To analyse the effect of hypoxic interventions on high-intensity intermittent running performance in team-sport athletes. METHODS: A systematic literature search of five journal databases was performed. Percent change in performance (distance covered) in the Yo-Yo intermittent recovery test (level 1 and level 2 were used without differentiation) in hypoxic (natural or simulated altitude) and control (sea level or normoxic placebo) groups was meta-analyzed with a mixed model...
November 11, 2017: Sports Medicine
https://www.readbyqxmd.com/read/29116020/assessment-of-safety-and-efficacy-of-mesenchymal-stromal-cell-therapy-in-preclinical-models-of-acute-myocardial-infarction-a-systematic-review-protocol
#8
Carly C Barron, Manoj M Lalu, Duncan J Stewart, Dean Fergusson, Homer Yang, David Moher, Peter Liu, David Mazer, P J Devereaux, Lauralyn McIntyre
BACKGROUND: Despite advances in treatment, acute myocardial infarction (MI) is still associated with significant morbidity and mortality, especially in patients with extensive damage and scar formation. Based on some promising preclinical studies, there is interest in the use of mesenchymal stromal cells (MSCs) to promote cardiac repair after acute MI. However, there is a need for a systematic review of this evidence to summarize the efficacy and safety of MSCs in preclinical models of MI...
November 7, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29113607/directional-associations-between-memory-impairment-and-depressive-symptoms-data-from-a-longitudinal-sample-and-meta-analysis
#9
Junhong Yu, Hui-Ying Lim, Fadzillah Nur D/O Mohd Abdullah, Hui-Minn Chan, Rathi Mahendran, Roger Ho, Ee-Heok Kua, Michael John Power, Lei Feng
BACKGROUND: Previous cross-lagged studies on depression and memory impairment among the elderly have revealed conflicting findings relating to the direction of influence between depression and memory impairment. The current study aims to clarify this direction of influence by examining the cross-lagged relationships between memory impairment and depression in an Asian sample of elderly community dwellers, as well as synthesizing previous relevant cross-lagged findings via a meta-analysis...
November 8, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29099282/dna-methylation-and-obesity-traits-an-epigenome-wide-association-study-the-regicor-study
#10
Sergi Sayols-Baixeras, Isaac Subirana, Alba Fernández-Sanlés, Mariano Sentí, Carla Lluís-Ganella, Jaume Marrugat, Roberto Elosua
Obesity is associated with increased risk of several diseases and has become epidemic. Obesity is highly heritable but the genetic variants identified by genome-wide association studies explain only limited variability. Epigenetics could contribute to explain the missing variability. The study aim was to discover differential methylation patterns related to obesity. We designed an epigenome-wide association study with a discovery phase in a subsample of 641 REGICOR study participants, validated by analysis of 2,515 participants in the Framingham Offspring Study...
November 3, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/29095432/pregnancy-induced-hypertension-and-neonatal-outcomes-a-systematic-review-and-meta-analysis
#11
A Razak, A Florendo-Chin, L Banfield, M G Abdul Wahab, S McDonald, P S Shah, A Mukerji
OBJECTIVE: Pregnancy-induced hypertension (PIH) is associated with preterm delivery but its independent impact on neonatal outcomes remains unclear. We sought to systematically review and meta-analyze clinical outcomes of preterm infants <37 weeks' gestation born to mothers with and without PIH. STUDY DESIGN: Medline, Embase, PsychINFO and CINAHL were searched from January 2000 to October 2016. Studies with low-moderate risk of bias reporting neonatal outcomes based on PIH as primary exposure variable were included...
November 2, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29078111/markers-of-coagulation-activation-inflammation-and-fibrinolysis-as-predictors-of-poor-outcomes-after-pediatric-venous-thromboembolism-a-systematic-review-and-meta-analysis
#12
REVIEW
Ayesha Zia, Joy Russell, Ravi Sarode, Surendranath R Veeram, Shellie Josephs, Kendra Malone, Song Zhang, Janna Journeycake
BACKGROUND: Sequelae of venous thromboembolism (VTE) in children include recurrence, development of post thrombotic syndrome (PTS) when venous return from a limb is affected and chronic thromboembolic pulmonary hypertension (CTEPH) after pulmonary embolism. Identification of laboratory-based risk factors may be useful for individualized risk assessment for VTE sequelae. Coagulation activation and inflammation may contribute to their pathophysiology. We performed a systematic review to investigate the association between biomarkers of coagulation activation, inflammation and fibrinolysis and adverse VTE outcomes in children and young adults...
October 7, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29070664/epidemiology-of-recurrent-traumatic-brain-injury-in-the-general-population-a-systematic-review
#13
REVIEW
Oliver Lasry, Erin Y Liu, Guido Antonio Powell, Jessica Ruel-Laliberté, Judith Marcoux, David L Buckeridge
OBJECTIVE: To comprehensively assess recurrent traumatic brain injury (rTBI) risk and risk factors in the general population. METHODS: We systematically searched MEDLINE, EMBASE, and the references of included studies until January 16, 2017, for general population observational studies reporting rTBI risk or risk factors. Estimates were not meta-analyzed due to significant methodologic heterogeneity between studies, which was evaluated using meta-regression. RESULTS: Twenty-two studies reported recurrence risk and 11 reported on 27 potential risk factors...
October 25, 2017: Neurology
https://www.readbyqxmd.com/read/29069849/association-of-four-genetic-polymorphisms-in-the-vascular-endothelial-growth-factor-a-gene-and-development-of-ovarian-cancer-a-meta-analysis
#14
Chao-Huan Xu, Zhong-Hui He, Hong Xu
This study meta-analyzed the literature on possible association of four polymorphisms (+936C/T, -460C/T, -2578C/A and -1154G/A) in the vascular endothelial growth factor (VEGF)-A gene with risk of ovarian cancer. Meta-analysis of 7 case-control studies involving +936C/T, 4 studies involving -460C/T, 4 studies involving -2578C/A and 2 studies involving -1154G/A showed significant association between -460C/T and ovarian cancer risk. This risk was observed in the total population (allelic model, OR 1.80, 95% CI 1...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29055798/prospective-memory-in-bipolar-disorder-a-meta-analysis
#15
Fu-Chun Zhou, Yuan-Yuan Wang, Wei Zheng, Gabor S Ungvari, Chee H Ng, Zhen Yuan, Yu-Tao Xiang
There are conflicting findings about prospective memory (PM) performance in bipolar disorder. This meta-analysis systematically examined PM in patients with bipolar disorders. Articles were systematically searched in both English and Chinese databases, from their inception to Nov 15, 2016. Only case-control studies on PM in bipolar patients were included for analyses. The random effect model was used in all meta-analytic outcomes. Four studies (n = 390) comparing PM performance between patients with bipolar disorder (n = 208) and healthy controls (n = 182) were included...
September 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29055456/vitamin-b12-folate-and-homocysteine-levels-and-multiple-sclerosis-a-meta-analysis
#16
REVIEW
Efthimios Dardiotis, Stylianos Arseniou, Maria Sokratous, Zisis Tsouris, Vasileios Siokas, Alexios-Fotios A Mentis, Amalia Michalopoulou, Athina Andravizou, Metaxia Dastamani, Konstantinos Paterakis, Dimitrios Bogdanos, Alexandros Brotis
BACKGROUND: Multiple sclerosis (MS) is a demyelinating and disabling inflammatory disease of the central nervous system. Several factors contribute to MS pathogenesis including genetic-environmental interactions. Case-control studies suggest that there might be associations between MS and homocysteine (Hcy), vitamin B12, and folate blood levels. AIM: To meta-analyze all available data describing associations between MS and serum or plasma Hcy, vitamin B12, and folate levels...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29054676/is-diagnostic-performance-of-quantitative-2d-shear-wave-elastography-optimal-for-clinical-classification-of-benign-and-malignant-thyroid-nodules-a-systematic-review-and-meta-analysis
#17
Haliimah A Nattabi, Norhafidzah M Sharif, Noorazrul Yahya, Rozilawati Ahmad, Mazlyfarina Mohamad, Faizah M Zaki, Ahmad N Yusoff
RATIONALE AND OBJECTIVE: This study is a dedicated 2D-shear wave elastography (2D-SWE) review aimed at systematically eliciting up-to-date evidence of its clinical value in differential diagnosis of benign and malignant thyroid nodules. METHODS: PubMed, Web of Science, and Scopus databases were searched for studies assessing the diagnostic value of 2D-SWE for thyroid malignancy risk stratification published until December 2016. The retrieved titles and abstracts were screened and evaluated according to the predefined inclusion and exclusion criteria...
October 17, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29050510/effects-of-yoga-on-chronic-neck-pain-a-systematic-review-and-meta-analysis
#18
Holger Cramer, Petra Klose, Benno Brinkhaus, Andreas Michalsen, Gustav Dobos
OBJECTIVE: The aim of this review was to systematically assess and meta-analyze the effectiveness of yoga in relieving chronic neck pain. METHODS: PubMed/MEDLINE, the Cochrane Library, Scopus, and IndMED were screened through January 2017 for randomized controlled trials assessing neck pain intensity and/or neck pain-related disability in chronic neck pain patients. Secondary outcome measures included quality of life, mood, and safety. Risk of bias was assessed using the Cochrane tool...
November 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29045808/kaplan-meier-survival-analysis-overestimates-cumulative-incidence-of-health-related-events-in-the-presence-of-competing-risks-a-meta-analysis
#19
REVIEW
Sarah Lacny, Todd Wilson, Fiona Clement, Derek J Roberts, Peter Faris, William A Ghali, Deborah A Marshall
OBJECTIVE: Kaplan-Meier survival analysis may overestimate cumulative incidence in competing risks (CR) settings. The clinical significance of this overestimation has been questioned and CR methods are infrequently used. This meta-analysis compares the Kaplan-Meier method to the cumulative incidence function (CIF), a CR method. STUDY DESIGN AND SETTING: We searched MEDLINE, EMBASE, BIOSIS Previews, Web of Science (1992-2016), and article bibliographies for studies estimating cumulative incidence using the Kaplan-Meier method and CIF...
October 15, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29044560/regulating-the-transcriptomes-that-mediate-the-conversion-of-fibroblasts-to-various-nervous-system-neural-cell-types
#20
Niusha Khazaei, Shima Rastegar-Pouyani, Nicholas O'Toole, Ping Wee, Abdulshakour Mohammadnia, Moein Yaqubi
Our understanding of the mechanism of cell fate transition during the direct reprogramming of fibroblasts into various central nervous system (CNS) neural cell types has been limited by the lack of a comprehensive analysis on generated cells, independently and in comparison with other CNS neural cell types. Here, we applied an integrative approach on 18 independent high throughput expression data sets to gain insight into the regulation of the transcriptome during the conversion of fibroblasts into induced neural stem cells, induced neurons, induced astrocytes, and induced oligodendrocyte progenitor cells...
October 17, 2017: Journal of Cellular Physiology
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