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https://www.readbyqxmd.com/read/28339493/timely-meta-analysis-on-the-efficacy-of-adoptive-immunotherapy-for-hepatocellular-carcinoma-patients-after-curative-therapy
#1
Han-Yue Mo, Ying-Yang Liao, Xue-Mei You, Alessandro Cucchetti, Bao-Hong Yuan, Ru-Hong Li, Jian-Hong Zhong, Le-Qun Li
AIMS: The role of adoptive immunotherapy (AIT) for patients with hepatocellular carcinoma (HCC) who have received curative therapy is still not well illustrated. This timely meta-analysis aims to update the current evidence on efficacy and safety of AIT for patients with HCC who have received curative therapy. METHODS: We searched PubMed, EMBASE, Scopus and the Cochrane Library Through January 2017 for relevant studies. Mortality and tumor recurrence were compared between patients with or without adjuvant AIT...
2017: PloS One
https://www.readbyqxmd.com/read/28334838/neutrophil-mediated-il-6-receptor-trans-signaling-and-the-risk-of-chronic-obstructive-pulmonary-disease-and-asthma
#2
Neda Farahi, Ellie Paige, Jozef Balla, Emily Prudence, Ricardo C Ferreira, Mark Southwood, Sarah L Appleby, Per Bakke, Amund Gulsvik, Augusto A Litonjua, David Sparrow, Edwin K Silverman, Michael H Cho, John Danesh, Dirk S Paul, Daniel F Freitag, Edwin R Chilvers
The Asp358Ala variant in the interleukin-6 receptor (IL-6R) gene has been implicated in asthma, autoimmune and cardiovascular disorders, but its role in other respiratory conditions such as chronic obstructive pulmonary disease (COPD) has not been investigated. The aims of this study were to evaluate whether there is an association between Asp358Ala and COPD or asthma risk, and to explore the role of the Asp358Ala variant in sIL-6R shedding from neutrophils and its pro-inflammatory effects in the lung. We undertook logistic regression using data from the UK Biobank and the ECLIPSE COPD cohort...
February 17, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28325253/efficacy-and-safety-of-olanzapine-for-the-prevention-of-chemotherapy-induced-nausea-and-vomiting-a-systematic-review-and-meta-analysis
#3
REVIEW
Jukapun Yoodee, Unchalee Permsuwan, Mantiwee Nimworapan
BACKGROUND: Olanzapine is an anti-psychotic drug that has been used for preventing and treating Chemotherapy-Induced Nausea and Vomiting (CINV). This study aimed to systematically review and meta-analyze the efficacy and safety of olanzapine for prophylaxis and treatment of CINV. METHODS: We conducted a systematic literature search of MEDLINE, EMBASE, SCOPUS, and the Cochrane Central Register of Controlled Trials-CENTRAL up to July 15, 2016. All observational and intervention studies were included, but only the intervention studies were pooled for meta-analysis...
April 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28318491/late-life-depression-hippocampal-volumes-and-hypothalamic-pituitary-adrenal-axis-regulation-a-systematic-review-and-meta-analysis
#4
Mirjam I Geerlings, Lotte Gerritsen
BACKGROUND: We systematically reviewed and meta-analyzed the association of late-life depression (LLD) with hippocampal volume (HCV) and total brain volume (TBV), and of cortisol levels with HCV, including subgroup analyses of depression characteristics and methodological aspects. METHODS: We searched PubMed and Embase for original studies that examined the cross-sectional relationship between LLD and HCV or TBV, and 46 studies fulfilled the inclusion criteria. Standardized mean differences (Hedges' g) between LLD and control subjects were calculated from crude or adjusted brain volumes using random effects...
January 27, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28318279/substance-use-prevention-and-treatment-outcomes-for-emerging-adults-in-non-college-settings-a-meta-analysis
#5
Jordan P Davis, Douglas C Smith, Daniel A Briley
Emerging adults have the highest prevalence rate of alcohol and drug use and represent a large proportion of treatment admissions in the United States. Those who do not attend college experience higher rates of use and may not have similar advantages as those attending college. A systematic review included studies investigating prevention and treatment outcomes among emerging adults in non-college settings. We included studies reporting an average age between 18 and 25 conducted outside of college settings...
March 20, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28303605/performance-of-scoring-systems-to-predict-mortality-of-patients-with-acute-on-chronic-liver-failure-a-systematic-review-and-meta-analysis
#6
Yi-Xiang Zheng, Xiao Zhong, Ya-Jun Li, Xue-Gong Fan
BACKGROUND: Acute-on-chronic liver failure (ACLF) has characteristic feature of multisystem organ failure, rapid progression and low early transplant-free survival. AIM: We performed a meta-analysis to determine the accuracy of five scoring systems in predicting mortality of ACLF patients. METHODS: A systematic database search was performed and retrieved articles were graded according to methodological quality. Collated data was meta-analyzed by hierarchical summarized receiver operating characteristic (HSROC) model and bivariate model to evaluate the diagnostic accuracy of scoring systems RESULT: Of 4223 studies identified, 26 studies involving 4732 ACLF patients were included...
March 16, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28300059/genetic-basis-for-variation-in-plasma-il-18-levels-in-persons-with-chronic-hepatitis-c-virus-and-human-immunodeficiency-virus-1-infections
#7
C Vergara, C Thio, R Latanich, A L Cox, G D Kirk, S H Mehta, M Busch, E L Murphy, M C Villacres, M G Peters, A L French, E Golub, J Eron, C D Lahiri, S Shrestha, D Gustafson, M Young, K Anastos, B Aouizerat, A Y Kim, G Lauer, D L Thomas, P Duggal
Inflammasomes are multi-protein complexes integrating pathogen-triggered signaling leading to the generation of pro-inflammatory cytokines including interleukin-18 (IL-18). Hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections are associated with elevated IL-18, suggesting inflammasome activation. However, there is marked person-to-person variation in the inflammasome response to HCV and HIV. We hypothesized that host genetics may explain this variation. To test this, we analyzed the associations of plasma IL-18 levels and polymorphisms in 10 genes in the inflammasome cascade...
March 16, 2017: Genes and Immunity
https://www.readbyqxmd.com/read/28290837/-the-choice-of-anticoagulant-therapy-in-patients-with-non-valvular-atrial-fibrillation-and-chronic-kidney-disease
#8
N A Koziolova, E A Polyanskaya, I I Kolegova
The review shows the prevalence of atrial fibrillation (AF) in patients with chronic kidney disease (CKD), depending on the severity of the disease. Patients with non-valvular AF and CKD have a significantly increased risk of both bleeding and thromboembolic complications, and death from all causes. Evaluation of the results of randomized clinical trials (RCTs), meta-analyzes of RCTs demonstrated the advantages of the new oral anticoagulants (NOAC), such as dabigatran, rivaroxaban, apixaban, compared with warfarin in reducing the risk of bleeding in patients with AF and CKD in predialysis stage...
January 2017: Kardiologiia
https://www.readbyqxmd.com/read/28290805/-the-prediction-model-of-cardiovascular-events-among-the-russian-population-methodological-aspects
#9
A V Kontsevaya, S A Shalnova, E I Suvorova, Y A Balanova, S E Evstifeeva, A E Imaeva, A V Kapustina, A D Deev, Y A Karpov, O D Ostroumova, F T Ageev, O S Blinkov, I Yu Zinchuk, K A Repekto, A Boytsov S
Modeling is the common approach for predicting not only the population health, but also the social and economic burden of disease, which is an important argument while making decisions in health care and prevention. AIM: To develop the model for predicting cardiovascular risk, applicable for the assessment of clinical and socio-economic effects of preventive and therapeutic actions at the level of the whole population or part (region, city, group of patients). MATERIAL AND METHODS: An analytical model for making decision was performed by using a Markov model consisting of Markov states and probabilities of transition from one state to another within a certain time interval...
December 2016: Kardiologiia
https://www.readbyqxmd.com/read/28290169/a-systematic-review-and-meta-analysis-of-outcomes-following-mitral-valve-surgery-in-patients-with-significant-functional-mitral-regurgitation-and-left-ventricular-dysfunction
#10
Ali Andalib, Michael Chetrit, Masha Eberg, Kristian B Filion, Pascal Thériault-Lauzier, Ruediger Lange, Jean Buithieu, Giuseppe Martucci, Mark Eisenberg, Steven F Bolling, Nicolo Piazza
BACKGROUND: The surgical correction of functional mitral regurgitation (MR) remains challenging and controversial. The study aim was to systematically review the outcomes of surgical mitral valve repair (MVRpr) and mitral valve replacement (MVR) in patients with significant functional MR and left ventricular (LV) dysfunction. METHODS: A meta-analysis was performed of published data acquired from patients with moderate to severe functional MR and LV ejection fraction (LVEF) <40% who underwent surgical MVRpr or MVR...
November 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28287813/effect-of-consanguinity-on-low-birth-weight-a-meta-analysis
#11
REVIEW
Jalal Poorolajal, Pegah Ameri, Alireza Soltanian, Masoud Bahrami
BACKGROUND: Consanguinity (when couples share at least one common ancestor) is a public health issue with a variety of distributions and incidence rates worldwide. Several epidemiological studies have explored the association between consanguinity and low birth weight (LBW). However, the results are inconsistent. This meta-analysis aimed to explore the overall association between consanguineous marriage and LBW. METHODS: We searched PubMed, Web of Science, Scopus, ScienceDirect, and reference lists of articles up to May 2015...
March 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28286481/a-systematic-review-and-meta-analysis-of-the-haemodynamic-effects-of-cannabidiol
#12
Salahaden R Sultan, Sophie A Millar, Timothy J England, Saoirse E O'Sullivan
Despite cannabidiol (CBD) having numerous cardiovascular effects in vitro, its haemodynamic effects in vivo are unclear. Nonetheless, the clinical use of CBD (Epidiolex) is becoming more widespread. The aim of this systematic review was to establish whether CBD is associated with changes in haemodynamics in vivo. Twenty-five studies that assessed the haemodynamic effects of CBD (from PubMed, Medline and EMBASE) were systematically reviewed and meta-analyzed. Data on blood pressure (BP), heart rate (HR), and blood flow (BF) were extracted and analyzed using random effects models...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28285959/impact-of-perioperative-fluid-administration-on-early-outcomes-after-pancreatoduodenectomy-a-meta-analysis
#13
REVIEW
Yeqian Huang, Terence C Chua, Anthony J Gill, Jaswinder S Samra
BACKGROUND: Pancreatoduodenectomy (PD) remains a technically challenging surgical procedure with morbidity rates ranging between 30 and 50%. It is suggested that the liberal use of fluids is associated with a poor perioperative outcome. This review examines the impact of fluid administration on outcomes after PD. METHODS: A literature search was conducted using the MEDLINE, EMBASE and PubMed database (June 1966-June 2016). Studies identified were appraised with standard selection criteria...
February 28, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28284845/risks-of-malignancies-related-to-tofacitinib-and-biological-drugs-in-rheumatoid-arthritis-systematic-review-meta-analysis-and-network-meta-analysis
#14
José Ramón Maneiro, Alejandro Souto, Juan J Gomez-Reino
OBJECTIVE: To summarize and compare the risks of malignancies accompanying biologic DMARDs (b-DMARDs) and tofacitinib in rheumatoid arthritis (RA) in randomized clinical trials (RCTs) and long-term extension studies (LTEs). METHODS: Articles in Medline, Embase, Cochrane Library, and the Web of Science dated from 2000 to February 2015. Selection criteria were as follows: (1) focus on RCTs or LTEs in RA; (2) treatment with b-DMARDs or tofacitinib; (3) data on malignancies; and (4) a minimum follow-up of 12 weeks...
February 16, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28275071/relations-of-metabolically-healthy-and-unhealthy-obesity-to-digital-vascular-function-in-three-community-based-cohorts-a-meta-analysis
#15
REVIEW
Luisa C C Brant, Na Wang, Francisco M Ojeda, Michael LaValley, Sandhi M Barreto, Emelia J Benjamin, Gary F Mitchell, Ramachandran S Vasan, Joseph N Palmisano, Thomas Münzel, Stefan Blankenberg, Philipp S Wild, Tanja Zeller, Antonio L P Ribeiro, Renate B Schnabel, Naomi M Hamburg
BACKGROUND: Microvascular dysfunction is a marker of early vascular disease that predicts cardiovascular events. Whether metabolically healthy obese individuals have impaired microvascular function remains unclear. The aim of this study was to evaluate the relation of obesity phenotypes stratified by metabolic status to microvascular function. METHODS AND RESULTS: We meta-analyzed aggregate data from 3 large cohorts (Brazilian Longitudinal Study of Adult Health, the Framingham Heart Study, and the Gutenberg Heart Study; n=16 830 participants, age range 19-90, 51...
March 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28249650/interventions-for-the-management-of-radiotherapy-induced-xerostomia-and-hyposalivation-a-systematic-review-and-meta-analysis
#16
REVIEW
Valeria Mercadante, Arwa Al Hamad, Giovanni Lodi, Stephen Porter, Stefano Fedele
INTRODUCTION: Salivary gland hypofunction is a common and permanent adverse effect of radiotherapy to the head and neck. Randomised trials of available treatment modalities have produced unclear results and offer little reliable guidance for clinicians to inform evidence-based therapy. We have undertaken this systematic review and meta-analysis to estimate the effectiveness of available interventions for radiotherapy-induced xerostomia and hyposalivation. METHODS: We searched MEDLINE, Cochrane Central, EMBASE, AMED, and CINAHL database through July 2016 for randomised controlled trials comparing any topical or systemic intervention to active and/or non-active controls for the treatment of radiotherapy-induced xerostomia...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28248033/-contemporary-aspects-of-using-sildenafil
#17
E A Efremov, E V Kasatonova, Ya I Melnik, V V Simakov
Sildenafil has been thoroughly studied in 74 registered double-blind, placebo-controlled clinical trials assessing the efficacy and safety of the drug in a total of more than 16 000 men with erectile dysfunction (ED). However, practicing urologists have some questions regarding administering the drug in patients with multiple comorbidities. In this review, on a par with the now "classic" research, we outline the latest updates of meta-analyzes and comparative studies relating to the use of sildenafil in different groups of patients...
November 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28248032/-the-risk-of-bladder-cancer-in-patients-with-prostatic-hyperplasia-and-strategies-to-manage-this-combination
#18
Yu G Alyaev, A M Pshikhachev, A N Perekalina
The combination of bladder cancer with benign prostatic hyperplasia (BPH) occurs in 5-27% of cases. The link between these diseases has not yet been closely investigated. The main role in the pathogenesis of bladder cancer combined with BPH is played by the residual urine and prolonged exposure of urothelium to the urine carcinogens. The choice of surgical treatment modality for the combination of non-muscle invasive bladder cancer and BPH is still a matter of debate. There is no consensus on the safety and appropriateness of simultaneous transurethral resection of the bladder and prostate in these patients...
November 2016: Urologii︠a︡
https://www.readbyqxmd.com/read/28238944/brain-correlates-of-hypnosis-a-systematic-review-and-meta-analytic-exploration
#19
REVIEW
Mathieu Landry, Michael Lifshitz, Amir Raz
Imaging of the living human brain elucidates the neural dynamics of hypnosis; however, few reliable brain patterns emerge across studies. Here, we methodically assess neuroimaging assays of hypnosis to uncover common neural configurations using a twofold approach. First, we systematically review research on the neural correlates of hypnotic phenomena; then, we meta-analyze these collective data seeking specific activation and deactivation patterns that typify hypnosis. Anchored around the role of top-down control processes, our comprehensive examination focuses on the involvement of intrinsic brain networks known to operationalize cognitive control and self-referential cognition, including the executive, salience, and default networks...
February 23, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28231030/safety-of-patient-mobilization-and-rehabilitation-in-the-icu-systematic-review-with-meta-analysis
#20
Peter Nydahl, Thiti Sricharoenchai, Saurabh Chandra, Firuzan Sari Kundt, Minxuan Huang, Magdalena Fischill, Dale M Needham
BACKGROUND: Early mobilization and rehabilitation of patients in intensive care units (ICU) may improve physical function, and reduce the duration of delirium, mechanical ventilation and ICU length of stay. However, safety concerns are an important barrier to widespread implementation. OBJECTIVE: To synthesize safety data regarding patient mobilization and rehabilitation in the ICU, including falls, removal of endotracheal tubes (ETT), removal or dysfunction of intravascular catheters, removal of other catheters/tubes, cardiac arrest, hemodynamic changes and desaturation...
February 23, 2017: Annals of the American Thoracic Society
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