Thomas A Miller, Edgar J Hernandez, J William Gaynor, Mark W Russell, Jane W Newburger, Wendy Chung, Elizabeth Goldmuntz, James F Cnota, Sinai C Zyblewski, William T Mahle, Victor Zak, Chitra Ravishankar, Jonathan R Kaltman, Brian W McCrindle, Shanelle Clarke, Jodie K Votava-Smith, Eric M Graham, Mike Seed, Nancy Rudd, Daniel Bernstein, Teresa M Lee, Mark Yandell, Martin Tristani-Firouzi
BACKGROUND: Recent large-scale sequencing efforts have shed light on the genetic contribution to the etiology of congenital heart defects (CHD); however, the relative impact of genetics on clinical outcomes remains less understood. Outcomes analyses using genetics are complicated by the intrinsic severity of the CHD lesion and interactions with conditionally dependent clinical variables. METHODS: Bayesian Networks were applied to describe the intertwined relationships between clinical variables, demography, and genetics in a cohort of children with single ventricle CHD...
September 27, 2023: Commun Med (Lond)