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https://www.readbyqxmd.com/read/29040973/sulforaphane-and-epigallocatechin-gallate-restore-estrogen-receptor-expression-by-modulating-epigenetic-events-in-the-breast-cancer-cell-line-mda-mb-231-a-systematic-review-and-meta-analysis
#1
Vincenza Gianfredi, Samuele Vannini, Massimo Moretti, Milena Villarini, Nicola Luigi Bragazzi, Alberto Izzotti, Daniele Nucci
BACKGROUND/AIMS: Epigenetics refers to modifications in gene activity and expression without alteration at the DNA sequence. Environment and diet could influence gene expression. Diet modifications may be meaningful in preventing and treating chronic diseases, cancer included. Dietary bioactive compounds, such as polyphenols (e.g., curcumin, resveratrol, or epigallocatechin gallate [EGCG]) or isothiocyanate (e.g., sulforaphane [SFN]), can regulate histone acetylation. The aim of this systematic review and meta-analysis was to evaluate the effect of SFN and EGCG on breast cancer (BC) cells cultured in vitro...
October 18, 2017: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/29040936/chemical-profiling-and-quantification-of-dan-deng-tong-nao-capsule-using-ultra-high-performance-liquid-chromatography-coupled-with-high-resolution-hybrid-quadruple-orbitrap-mass-spectrometry
#2
Xiao-Jing Lv, Zhi Sun, Pei-Le Wang, Jing Yang, Tan-Ye Xu, Qing-Quan Jia, Da-Wei Li, Fang-Yi Su, Zhen-Feng Zhu, Jian Kang, Xiao-Jian Zhang
Dan-Deng-Tong-Nao capsule (DDTN) was a traditional Chinese medicine (TCM) formula, and has been widely used for the treatment of stroke clinically which caused by blood stasis. However, the bioactive substances and mechanism are unclear because of the complex compositions in DDTN. In this research, An ultra high-performance liquid chromatography (UHPLC) coupled with hybrid quadruple-orbitrap mass spectrometry (Q-Orbitrap MS) method was utilized to identify the chemical constituents of DDTN. In total, 102 compounds including diterpenes, lactones, flavonoids, and phenolic acids were identified by the accurate masses and fragmentation pathways, and 18 of them were unambiguously determined by comparison of reference standards...
October 7, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29040028/elaboration-in-type-primary-structure-and-bioactivity-of-polysaccharides-derived-from-mollusks
#3
Ling Chong Wang, Liu Qing Di, Jun Song Li, Li Hong Hu, Jian Ming Cheng, Hao Wu
Over the past decades, numerous Mollusca species have received more attention in development and utilization as valuable bio-resources. Many efforts have been focused on investigating mollusk polysaccharides because of their rich content, ease of extraction, diversified sorts, specific structure, various biofunctions and potent activities. To date, many mollusks, especially species of gastropods, bivalves, or cephalopods, have been reported containing polysaccharide compounds in tissues with abundant amount, and most of polysaccharides are obtainable through combining techniques of extraction, separation and purification...
October 17, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29040011/bioactive-edible-films-for-food-applications-influence-of-the-bioactive-compounds-on-film-structure-and-properties
#4
Nasreddine Benbettaïeb, Thomas Karbowiak, Frédéric Debeaufort
Nowadays, a new generation of edible films is being especially designed for incorporating antimicrobials, antioxidants, enzymes or functional ingredients. Edible films made from natural biopolymers become the focus of many research works as an alternative to synthetic food packaging due to their edibility, biodegradability and compostability as well as to their use as active packaging. Active compounds incorporated in edible films could protect foods against deterioration during storage and therefore extend their shelf life...
October 17, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29039930/enantioselective-decarboxylative-cyanation-employing-cooperative-photoredox-catalysis-and-copper-catalysis
#5
Dinghai Wang, Na Zhu, Pinhong Chen, Zhenyang Lin, Guosheng Liu
The merger of photoredox catalysis with asymmetric copper catalysis have been realized to convert achiral carboxylic acids into enantiomerically enriched alkyl nitriles. Under mild reaction condition, the reaction exhibits broad substrate scope, high yields and high enantioselectivities. Furthermore, the reaction can be scaled up to synthesize key chiral intermediates to bioactive compounds.
October 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29035535/report-and-application-of-a-tool-compound-dataset
#6
Kyle V Butler, Ian A MacDonald, Nathaniel A Hathaway, Jian Jin
Small molecule tool compounds have enabled profound advances in life science research. These chemicals are potent, cell active, and selective, and thus, are suitable for interrogating biological processes. For these chemicals to be useful they must be correctly characterized and researchers must be aware of them. We mined the ChEMBL bioactivity database to identify high quality tool compounds in an unbiased way. We identified 407 best-in-class compounds for 278 protein targets, and these are reported in an annotated dataset...
October 16, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29034745/withanolide-production-by-fungal-endophyte-isolated-from-withania-somnifera
#7
Muthukrishnan Sathiyabama, Ramalingam Parthasarathy
Withanolides, the secondary metabolite from Withania species is used in Ayurvedic medicine and now proved to have potential use in treating cardiovascular, Alzheimer's disease, etc. Its production in plants varies between genotypes with very low yield. For improved industrial commercialisation, there is a need to increase its production. Endophytic fungi are symbiotically associated with plants and can synthesise the same bioactive compounds and natural products as their host plant. There are no reports available on withanolide-producing (endophytic) fungi...
October 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29034382/environmental-photochemistry-of-dienogest-phototransformation-to-estrogenic-products-and-increased-environmental-persistence-via-reversible-photohydration
#8
Nicholas C Pflug, Madeline K Hankard, Stephanie M Berg, Meghan O'Connor, James B Gloer, Edward P Kolodziej, David M Cwiertny, Kristine H Wammer
Potent trienone and dienone steroid hormones undergo a coupled photohydration (in light)-thermal dehydration (in dark) cycle that ultimately increases their environmental persistence. Here, we studied the photolysis of dienogest, a dienone progestin prescribed as a next-generation oral contraceptive, and used high resolution mass spectrometry and both 1D and 2D nuclear magnetic resonance spectroscopy to identify its phototransformation products. Dienogest undergoes rapid direct photolysis (t1/2 ∼ 1-10 min), forming complex photoproduct mixtures across the pH range examined (pH 2 to 7)...
October 16, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29034200/promising-effect-of-rosa-damascena-extract-on-high-fat-diet-induced-nonalcoholic-fatty-liver
#9
Ida Davoodi, Roja Rahimi, Mohammad Abdollahi, Fatemeh Farzaei, Mohammad Hosein Farzaei, Zahra Memariani, Fariba Najafi
NAFLD is a chronic liver disease that affects a high proportion of the world's population which causes metabolic and hepatic damages. Rosa damascena Mill is traditionally used as a dietary supplement for liver disorders. This study was carried out to determine the beneficial effect of standardized extract of R. damascena on animal model of nonalcoholic fatty liver disease (NAFLD). NAFLD was induced by high-fat diet (HFD) in Wistar rats. HFD rats showed an increase (p < 0.05) in the plasma lipid levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and reduced the high-density lipoprotein (HDL) levels...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29034184/understanding-nutrition-and-immunity-in-disease-management
#10
REVIEW
Edwin L Cooper, Melissa J Ma
As we search for answers to modern medicine's most prevalent and challenging problems, the relationship between nutrition, immunity, and biological function of various natural compounds are preimminent. Nutritional research involving genomics provides rational capabilities for preventing disease. Scientific advances in genomic sequencing reveal opportunities for exploring diet-health relationships and potential for individual, genotype based dietary recommendations. Utilizing molecular and genetic technology to analyze impact of nutrition on genomics and metabolism reveals that nutrients may influence certain innate and/or acquired immune functions...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29033932/from-cocoa-to-chocolate-the-impact-of-processing-on-in-vitro-antioxidant-activity-and-the-effects-of-chocolate-on-antioxidant-markers-in-vivo
#11
REVIEW
Carla D Di Mattia, Giampiero Sacchetti, Dino Mastrocola, Mauro Serafini
Chocolate is a product processed from cocoa rich in flavonoids, antioxidant compounds, and bioactive ingredients that have been associated with both its healthy and sensory properties. Chocolate production consists of a multistep process which, starting from cocoa beans, involves fermentation, drying, roasting, nib grinding and refining, conching, and tempering. During cocoa processing, the naturally occurring antioxidants (flavonoids) are lost, while others, such as Maillard reaction products, are formed. The final content of antioxidant compounds and the antioxidant activity of chocolate is a function of several variables, some related to the raw material and others related to processing and formulation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29032103/mast-cells-in-atherosclerotic-cardiovascular-disease-activators-and-actions
#12
Petri T Kovanen, Ilze Bot
Mast cells are potent actors involved in inflammatory reactions in various tissues, including both in the intimal and the adventitial layers of atherosclerotic arteries. In the arterial intima, the site of atherogenesis, mast cells are activated to degranulate, and thereby triggered to release an abundance of preformed inflammatory mediators, notably histamine, heparin, neutral proteases and cytokines stored in their cytoplasmic secretory granules. Depending on the stimulus, mast cell activation may also launch prolonged synthesis and secretion of single bioactive molecules, such as cytokines and derivatives of arachidonic acid...
October 12, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29031060/an-insight-into-the-biological-activities-of-heterocyclic-fatty-acid-hybrid-molecules
#13
REVIEW
Vijayendar Venepally, Ram Chandra Reddy Jala
Heterocyclic compounds are the interesting core structures for the development of new bioactive compounds. Fatty acids are derived from renewable raw materials and exhibit various biological activities. Several researchers are amalgamating these two bioactive components to yield bioactive hybrid molecules with some desirable features. Heterocyclic-fatty acid hybrid derivatives are a new class of heterocyclic compounds with a broad range of biological activities and significance in the field of medicinal chemistry...
October 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29030688/neurotrophic-function-of-phytochemicals-for-neuroprotection-in-aging-and-neurodegenerative-disorders-modulation-of-intracellular-signaling-and-gene-expression
#14
REVIEW
Makoto Naoi, Keiko Inaba-Hasegawa, Masayo Shamoto-Nagai, Wakako Maruyama
Bioactive compounds in food and beverages have been reported to promote health and prevent age-associated decline in cognitive, motor and sensory activities, and emotional function. Phytochemicals, a ubiquitous class of plant secondary metabolites, protect neuronal cells by interaction with cellular activities, in addition to the antioxidant and anti-inflammatory function. In aging and age-associated neurodegenerative disorders, phytochemicals protect neuronal cells by neurotrophic factor-mimic activity, in addition to suppression of apoptosis signaling in mitochondria...
October 13, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29029455/mobilization-studies-in-mice-deficient-in-sphingosine-kinase-2-support-a-crucial-role-of-the-plasma-level-of-sphingosine-1-phosphate-in-the-egress-of-hematopoietic-stem-progenitor-cells
#15
Mateusz Adamiak, Lakshman Chelvarajan, Kevin R Lynch, Webster L Santos, Ahmed Abdel-Latif, Mariusz Z Ratajczak
Sphingosine-1-phosphate (S1P) is a bioactive lipid involved in cell signaling and, if released from cells, also plays a crucial role in regulating the trafficking of lympho-hematopoietic cells, including primitive hematopoietic stem/progenitor cells (HSPCs). It has been demonstrated that S1P chemoattracts HSPCs, and its level in peripheral blood creates a gradient directing egress of these cells during mobilization. In this paper we analyzed hematopoiesis in mice deficient in sphingosine kinase 2 (Sphk2-KO mice) and studied the effect of this mutation on plasma S1P levels...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029346/botanical-compound-p-anisaldehyde-repels-larval-lone-star-tick-acari-ixodidae-and-halts-reproduction-by-gravid-adults
#16
Allan T Showler, Jessica L Harlien
The lone star tick, Amblyomma americanum (L.), widely distributed across eastern, southeastern, and midwestern regions of the United States and south into Mexico, is an obligate blood feeder that attaches to three hosts during the larval, nymphal, and adult stages. White-tailed deer and wild turkey are common hosts, as well as a wide variety of other avian and mammalian hosts. Amblyomma americanum is the most frequently reported species of tick to bite humans in the southeastern and southcentral United States, and it can transmit diseases that include erhlichiosis, rickettsiosis, tularemia, and protozoan infections...
October 4, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29029251/effects-of-the-botanical-compound-p-anisaldehyde-on-horn-fly-diptera-muscidae-repellency-mortality-and-reproduction
#17
Allan T Showler, Jessica L Harlien
The horn fly, Haematobia irritans irritans (L.) (Diptera: Muscidae), is an economically important obligate blood feeder that mainly attacks cattle in Europe, Asia, and North and South America. As horn fly resistance to conventional insecticides becomes more common, alternative control tactics, such as application of bioactive botanical natural products are being investigated. p-Anisaldehyde has been found in many plant species, and it has shown effects that include mortality, attractancy, and interference with host seeking...
October 4, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29027933/dpph-radical-scavenging-and-postprandial-hyperglycemia-inhibition-activities-and-flavonoid-composition-analysis-of-hawk-tea-by-uplc-dad-and-uplc-q-tof-ms-e
#18
Xuan Xiao, Lijia Xu, Huagang Hu, Yinjun Yang, Xinyao Zhang, Yong Peng, Peigen Xiao
Hawk tea (Litsea coreana Lévl. var. Lanuginosa (Migo) Yen C. Yang & P.H. Huang), a very popular herbal tea material, has attracted more and more attention due to its high antioxidant properties and possible therapeutic effect on type II diabetes mellitus. The raw materials of Hawk tea are usually divided into three kinds: bud tea (BT), primary leaf tea (PLT) and mature leaf tea (MLT). In this study, the DPPH radical scavenging activity and the antimicrobial properties of these three kinds of Hawk tea from different regions were comparatively investigated, and a ultra-high performance liquid chromatographic coupled with a photodiode array detector (UPLC-DAD) method was employed for comparison of the three major flavonoid constituents, including hyperoside, isoquercitrin and astragalin, in different samples of Hawk tea...
October 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29027475/antimould-microbial-and-plant-metabolites-with-potential-use-in-intelligent-food-packaging
#19
Francesca Valerio, Marco Masi, Alessio Cimmino, Seyed Arash Moeini, Paola Lavermicocca, Antonio Evidente
Moulds food infestation is a heavy dangerous problem for human health and also could generate heavy economic losses. The intelligent packaging using eco-friendly biodegradable biofilm incorporating bioactive natural safe compounds represents a new frontier. This manuscript reports the inhibitory activity of 12 bacterial, fungal and plant metabolites against Penicillium roqueforti and Aspergillus niger. Among them α-costic acid and ungeremine (3 and 12) are the most promising as potential biofungicide against both fungal strains...
October 13, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29025293/berberine-induces-apoptotic-cell-death-via-activation-of-caspase-3-and-8-in-hl-60-human-leukemia-cells-nuclear-localization-and-structure-activity-relationships
#20
Shinya Okubo, Takuhiro Uto, Aya Goto, Hiroyuki Tanaka, Tsuyoshi Nishioku, Katsushi Yamada, Yukihiro Shoyama
Berberine (BBR), an isoquinoline alkaloid, is a well-known bioactive compound contained in medicinal plants used in traditional and folk medicines. In this study, we investigated the subcellular localization and the apoptotic mechanisms of BBR were elucidated. First, we confirmed the incorporation of BBR into the cell visually. BBR showed antiproliferative activity and promptly localized to the nucleus from 5[Formula: see text]min to 15[Formula: see text]min after BBR treatment in HL-60 human promyelocytic leukemia cells...
2017: American Journal of Chinese Medicine
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