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https://www.readbyqxmd.com/read/28719343/preparation-and-properties-of-polyvinyl-alcohol-pva-and-hydroxylapatite-ha-hydrogels-for-cartilage-tissue-engineering
#1
F Yuan, M Ma, L Lu, Z Pan, W Zhou, J Cai, S Luo, W Zeng, F Yin
A novel bioactive hydrogel for cartilage tissue based on polyvinyl alcohol (PVA) and hydroxylapatite (HA) were prepared, the effects of its component contents on the mechanical properties and microstructure of the hydrogel were investigated. The important properties of the scaffold composites, such as density, porosity, compressive modulus and microstructure were studied and analyzed through various measurements and methods. The biodegradability of hydrogel was evaluated by soaking the samples into artificial degradation solution at body temperature (36 - 37 oC) in vitro...
May 20, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28719037/efficient-separation-of-high-purity-compounds-from-oxytropis-falcata-using-two-dimensional-preparative-chromatography
#2
Weidong Wang, Yanduo Tao, Lijin Jiao, Minxia Fan, Yun Shao, Qilan Wang, Lijuan Mei, Jun Dang
The separation of high-purity compounds from traditional Tibetan medicines plays an important role in investigating their bioactivity. Nevertheless, it is often quite difficult to isolate compounds with high purity because of the complexity of traditional Tibetan medicines. In this work, an offline two-dimensional reversed-phase preparative method was successfully developed for the separation of high-purity compounds from Oxytropis falcata. Based on the analysis results, an ODS C18 prep column was used for first-dimensional preparation, and 14...
July 18, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28718964/antiangiogenic-effects-of-ziyuglycoside-ii-a-major-active-compound-of-sanguisorba-officinalis-l
#3
Sang-Hyeon Nam, Khaliunaa Lkhagvasuren, Hee Won Seo, Jin-Kyung Kim
Ziyuglycoside II, a major bioactive compound of Sanguisorba officinalis L., displays anticancer potential against several human cancer cells. However, little information concerning its antiangiogenic properties and possible mechanisms is available. The aim of this study was to investigate the inhibitory effects of ziyuglycoside II on angiogenesis. Ziyuglycoside II inhibited the proliferation, migration, and tubule formation of human umbilical vein endothelial cells, as well as the number of microvessels growing from the aortic rings...
July 18, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28718519/cookies-elaborated-with-oat-and-common-bean-flours-improved-serum-markers-in-diabetic-rats
#4
Iza F Pérez-Ramírez, Laura J Becerril-Ocampo, Rosalía Reynoso-Camacho, Mayra Denise Herrera, S Horacio Guzmán-Maldonado, Raquel K Cruz-Bravo
BACKGROUND: Common beans have been associated to anti-diabetic effects, due to its high content of bioactive compounds. Nevertheless, its consumption has decreased worldwide. Therefore, there is an increasing interest in the development of novel functional foods elaborated with common beans. The aim of this study was to evaluate the anti-diabetic effect of oat-bean flour cookies, and to analyze its bioactive composition, using commercial oat-wheat cookies for comparative purposes. RESULTS: Oat-bean cookies (1...
July 17, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28718014/protein-hydrolysate-from-canned-sardine-and-brewing-by-products-improves-tnf-%C3%AE-induced-inflammation-in-an-intestinal-endothelial-co-culture-cell-model
#5
Elsa F Vieira, John Van Camp, Isabel M P L V O Ferreira, Charlotte Grootaert
PURPOSE: The anti-inflammatory activity of sardine protein hydrolysates (SPH) obtained by hydrolysis with proteases from brewing yeast surplus was ascertained. METHODS: For this purpose, a digested and desalted SPH fraction with molecular weight lower than 10 kDa was investigated using an endothelial cell line (EA.hy926) as such and in a co-culture model with an intestinal cell line (Caco-2). Effects of SPH <10 kDa on nitric oxide (NO) production, reactive oxygen species (ROS) inhibition and secretion of monocyte chemoattractant protein 1 (MCP-1), vascular endothelial growth factor (VEGF), chemokine IL-8 (IL-8) and intercellular adhesion molecule-1 (ICAM-1) were evaluated in TNF-α-treated and untreated cells...
July 17, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28717995/ovomucin-nanoparticles-promising-carriers-for-mucosal-delivery-of-drugs-and-bioactive-compounds
#6
Ali Akbari, Jianping Wu
Ovomucin, with a similar structure to mucin and gelation ability at room temperature, is a potential mucosal carrier. To evaluate this potential, the mucoadhesive property of ovomucin was studied by the tensile strength and rheology methods, and compared with three known mucoadhesive polymers, chitosan, polyacrylic acid (PAA), and alginate. Ovomucin particles were basically spherical in shape with an average size of ~572, 235 and 54 nm prepared at pH 5, 6.5, and 9, respectively. The absolute value of the zeta potential increased from ~ -51 mV at pH 5 to ~ -59 and -91 mV at pH 6...
July 17, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28716571/antiviral-effect-of-forsythoside-a-from-forsythia-suspensa-thunb-vahl-fruit-against-influenza-a-virus-through-reduction-of-viral-m1-protein
#7
Anna Hing-Yee Law, Cindy Lai-Hung Yang, Allan Sik-Yin Lau, Godfrey Chi-Fung Chan
ETHNOPHARMACOLOGICAL RELEVANCE: Yinqiaosan is a classical traditional Chinese medicine formula, which has been used to treat respiratory diseases since ancient China. It consists of nine herbs and among them, Forsythia suspensa (Thunb.) Vahl fruit is one of the major herbal components. Despite the long history of Yinqiaosan, the active compounds and the mechanisms of action of this formula remain elusive. AIM OF THE STUDY: The present study aimed to examine the suppressive effect of Yinqiaosan on influenza virus and to identify the active components in the formula targeting influenza...
July 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28716495/3-5-bis-3-dimethylaminomethyl-4-hydroxybenzylidene-4-piperidone-and-related-compounds-induce-glutathione-oxidation-and-mitochondria-mediated-cell-death-in-hct-116-colon-cancer-cells
#8
Eshwari Addala, Hossein Rafiei, Swagatika Das, Brian Bandy, Umashankar Das, Subhas S Karki, Jonathan R Dimmock
This study aims at investigating the cytotoxicity and some of the modes of action of 3,5-bis(3-dimethylamino-4-hydroxybenzylidene)-4-piperidone trihydrochloride 3 and two related compounds 2 (which lacks the dimethylaminomethyl groups) and 4 (which has an additional dimethylaminoethyl substituent in both aryl rings) in order to ascertain the contribution of dimethylaminoethyl substituent to bioactivity. The bioactivities of 2-4 were compared with curcumin 5. Both 2 and 3 displayed submicromolar GI50 values towards HCT-116 cells and were significantly more potent than 4, 5 and 5-fluorouracil (5-FU)...
July 5, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28716424/molecular-cloning-of-an-ester-forming-triterpenoid-udp-glucose-28-o-glucosyltransferase-involved-in-saponin-biosynthesis-from-the-medicinal-plant-centella-asiatica
#9
Fernanda de Costa, Carla J S Barber, Yeon-Bok Kim, Darwin W Reed, Haixia Zhang, Arthur G Fett-Neto, Patrick S Covello
Triterpene saponins include bioactive compounds with structures consisting of triterpene aglycones (sapogenins) and one or more sugar moieties linked through acetal or ester glycosidic linkages at one or more sites. Centella asiatica (L.) Urban is a medicinal plant that contains bioactive ursane-type saponins, such as madecassoside and asiaticoside. In this work, glucosylation of triterpenoids in C. asiatica was investigated starting with plant extracts. An enzyme capable of glucosylating asiatic and madecassic acids was partially purified...
September 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28715803/antinociceptive-effects-of-isosakuranetin-in-a-rat-model-of-peripheral-neuropathy
#10
Shushan Jia, Yong Zhang, Jingui Yu
Chronic pain remains a challenging clinical reality, yet currently available analgesics are insufficient to meet clinical needs. Increasing attention has been paid to bioactive compounds from natural plants, which may be efficacious against pain. This study examined the antinociceptive effects of isosakuranetin, a plant-derived transient receptor potential melastatin 3 blocker, in a rat model of peripheral neuropathy. Adult male Sprague-Dawley rats were first allowed to go through the chronic constriction injury surgery to develop neuropathic pain...
July 18, 2017: Pharmacology
https://www.readbyqxmd.com/read/28714384/chemistry-in-the-bioactivity-of-chlorophylls-an-overview
#11
Antonio Pérez-Gálvez, Isabel Viera, María Roca
BACKGROUND: In addition to the considerable number of different chlorophyll structures originated naturally, prominent research is made to produce new specific semi-synthetic structures. The final target is to obtain chlorophyll derivatives with even better bioactive properties than those of the natural parent compounds. METHOD: A detailed, extensive and critic literature search have been made in Web of ScienceTM Results: Great efforts are applying to optimize the function of chlorophyll-based photosensitizers, to understand the molecular mechanisms of the antioxidant and antigenotoxic properties of chlorophyll derivatives and, lastly, to investigate new biological actions of them...
July 14, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28714383/novel-mannich-bases-as-potential-anticonvulsants-syntheses-characterization-and-biological-evaluation
#12
Amit Kumar Keshari, Aseem Tewari, Shweta Singh Verma, Shailendra K Saraf
BACKGROUND: Mannich bases are known to be an important pharmacophore or bioactive leads in the synthesis of various potential agents that have a variety of therapeutic activities like anticancer, antipsychotic, anticonvulsant, antimalarial, anti-inflammatory, antibacterial and so forth. Thus, in the present research, conjugation of moieties like 1,5-benzoxazepines and 1,5-benzothiazepines with secondary amines like piperazine, methyl piperazine and morpholine was carried out in a Mannich base with an anticipation of good anticonvulsant activity...
July 17, 2017: Central Nervous System Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28713815/bioinformatic-prediction-of-possible-targets-and-mechanisms-of-action-of-the-green-tea-compound-epigallocatechin-3-gallate-against-breast-cancer
#13
Xinqiang Song, Mu Zhang, Lei Chen, Qingsong Lin
Epigallocatechin-3-gallate (EGCG), a bioactive compound in green tea, is the most abundant and biologically active catechin, and it exerts multiple effects in humans through mechanisms that remain to be clarified. The present study used bioinformatics to identify possible mechanisms by which EGCG reduces risk of breast cancer. Possible human protein targets of EGCG were identified in the PubChem database, possible human gene targets were identified in the NCBI database, and then both sets of targets were analyzed using Ingenuity Pathway Analysis to predict molecular networks affected by EGCG in breast cancer...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28713372/nanoparticle-formulated-curcumin-prevents-posttherapeutic-disease-reactivation-and-reinfection-with-mycobacterium-tuberculosis-following-isoniazid-therapy
#14
Sultan Tousif, Dhiraj Kumar Singh, Sitabja Mukherjee, Shaheer Ahmad, Rakesh Arya, Ranjan Nanda, Anand Ranganathan, Maitree Bhattacharyya, Luc Van Kaer, Santosh K Kar, Gobardhan Das
Curcumin, the bioactive component of turmeric also known as "Indian Yellow Gold," exhibits therapeutic efficacy against several chronic inflammatory and infectious diseases. Even though considered as a wonder drug pertaining to a myriad of reported benefits, the translational potential of curcumin is limited by its low systemic bioavailability due to its poor intestinal absorption, rapid metabolism, and rapid systemic elimination. Therefore, the translational potential of this compound is specifically challenged by bioavailability issues, and several laboratories are making efforts to improve its bioavailability...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28713365/what-s-normal-immune-profiling-of-human-milk-from-healthy-women-living-in-different-geographical-and-socioeconomic-settings
#15
Lorena Ruiz, Irene Espinosa-Martos, Cristina García-Carral, Susana Manzano, Michelle K McGuire, Courtney L Meehan, Mark A McGuire, Janet E Williams, James Foster, Daniel W Sellen, Elizabeth W Kamau-Mbuthia, Egidioh W Kamundia, Samwel Mbugua, Sophie E Moore, Linda J Kvist, Gloria E Otoo, Kimberly A Lackey, Katherine Flores, Rossina G Pareja, Lars Bode, Juan M Rodríguez
Human milk provides a very wide range of nutrients and bioactive components, including immune factors, human milk oligosaccharides, and a commensal microbiota. These factors are essential for interconnected processes including immunity programming and the development of a normal infant gastrointestinal microbiome. Newborn immune protection mostly relies on maternal immune factors provided through milk. However, studies dealing with an in-depth profiling of the different immune compounds present in human milk and with the assessment of their natural variation in healthy women from different populations are scarce...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28713336/development-and-use-of-a-real-time-quantitative-pcr-method-for-detecting-and-quantifying-equol-producing-bacteria-in-human-faecal-samples-and-slurry-cultures
#16
Lucía Vázquez, Lucía Guadamuro, Froilán Giganto, Baltasar Mayo, Ana B Flórez
This work introduces a novel real-time quantitative PCR (qPCR) protocol for detecting and quantifying equol-producing bacteria. To this end, two sets of primers targeting the dihydrodaidzein reductase (ddr) and tetrahydrodaidzein reductase (tdr) genes, which are involved in the synthesis of equol, were designed. The primers showed high specificity and sensitivity when used to examine DNA from control bacteria, such as Slackia isoflavoniconvertens, Slackia equolifaciens, Asaccharobacter celatus, Adlercreutzia equolifaciens, and Enterorhabdus mucosicola...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28712963/anti-quorum-sensing-activity-of-pistacia-atlantica-against-pseudomonas-aeruginosa-pao1-and-identification-of-its-bioactive-compounds
#17
H Kordbacheh, F Eftekhar, S N Ebrahimi
Pseudomonas aeruginosa is a multidrug resistant opportunistic pathogen and an important cause of nosocomial infections. Quorum-sensing (QS) is a process in which bacterial cell-cell communication can regulates production of many virulence factors including pigment formation and the ability to form biofilm which is essential for establishment of chronic infections. We examined the inhibitory effect of Pistacia atlantica (Anacardiaceae) methanolic leaf extract and its bioactive components on biofilm formation and pigment production by P...
July 13, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28711702/development-of-a-series-of-novel-4-anlinoquinazoline-derivatives-possessing-quinazoline-skeleton-design-synthesis-egfr-kinase-inhibitory-efficacy-and-evaluation-of-anticancer-activities-in%C3%A2-vitro
#18
Jin Chang, Hongyu Ren, Mingxia Zhao, Yan Chong, Wenwen Zhao, Yong He, Yunling Zhao, Huabei Zhang, Chuanmin Qi
4-anilinoquinazoline-based derivatives represent an attractive scaffold for small molecular EGFR-TKIs in the field of medicinal chemistry. A series of novel heterocyclic substituted derivatives have been designed, synthesized and evaluated their antitumor bioactivities as potential EGFR-TKIs. Most of the new compounds exhibited certain efficient inhibition potency for proliferation of a panel of five human cancer cells with IC50 values at the low micromolar level, and some of them possessed good broad-spectrum inhibition activities, compared to Gefitinib...
July 4, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28711498/promotion-of-hair-growth-by-newly-synthesized-ceramide-mimetic-compound
#19
Bu-Mahn Park, Soon-Sun Bak, Kyung-Oh Shin, Minhee Kim, Daehwan Kim, Sang-Hun Jung, Sekyoo Jeong, Young Kwan Sung, Hyunjong Kim
Based on the crucial roles of ceramides in skin barrier function, use of ceramides or their structural mimetic compounds, pseudoceramides, as cosmetic ingredients are getting more popular. While currently used pseudoceramides are intended to substitute the structural roles of ceramides in stratum corneum, development of bioactive pseudoceramides has been repeatedly reported. In this study, based on the potential involvement of sphingolipids in hair cycle regulation, we investigated the effects of newly synthesized pseudoceramide, bis-oleamido isopropyl alcohol (BOI), on hair growth using cultured human hair follicles and animal models...
July 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28710995/enhanced-and-green-extraction-polyphenols-and-furanocoumarins-from-fig-ficus-carica-l-leaves-using-deep-eutectic-solvents
#20
Tong Wang, Jiao Jiao, Qing-Yan Gai, Peng Wang, Na Guo, Li-Li Niu, Yu-Jie Fu
Nowadays, green extraction of bioactive compounds from medicinal plants has gained increasing attention. As green solvent, deep eutectic solvent (DES) have been highly rated to replace toxic organic solvents in extraction process. In present study, to simultaneous extraction five main bioactive compounds from fig leaves, DES was tailor-made. The tailor-made DES composed of a 3:3:3 molar ratio of glycerol, xylitol and D-(-)-Fructose showed enhanced extraction yields for five target compounds simultaneously compared with traditional methanol and non-tailor DESs...
July 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
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