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https://www.readbyqxmd.com/read/29232753/solvent-extraction-and-gc-ms-analysis-of-sesame-seeds-for-determination-of-bioactive-antioxidant-fatty-acid-fatty-oil-components
#1
Abdul Qadir, Athar Ali, Muhammad Arif, Abdulmohsen H Al-Rohaimi, Satya Prakash Singh, Usama Ahmad, Mohd Khalid, Arun Kumar
The seed kernels of Sesamum indicum L. (family: Pedaliaceae) were extracted with ethanol and yield of components determined by Gas Chromatography/Mass Spectrometry (GC/MS). The free radical scavenging activities of ethanolic extract against1, 1-Diphenyl-2-picrylhydrazyl (DPPH) were determined by UV spectrophotometer at 517 nm. Phytochemical screening revealed the presence of numerous bioactive compounds including steroids, phenolic, terpenoids, fatty acids and different types of ester compounds. The ethanolic extract was purified and analyzed by GC MS...
December 12, 2017: Drug Research
https://www.readbyqxmd.com/read/29232626/targeted-isolation-and-identification-of-bioactive-compounds-lowering-cholesterol-in-the-crude-extracts-of-crabapples-using-uplc-dad-ms-spe-nmr-based-on-pharmacology-guided-pls-da
#2
Chao Wen, Dongshan Wang, Xing Li, Tao Huang, Cheng Huang, Kaifeng Hu
The anti-hyperlipidemic effects of crude crabapple extracts derived from Malus 'Red jade', Malus hupehensis (Pamp.) Rehd. and Malus prunifolia (Willd.) Borkh. were evaluated on high-fat diet induced obese (HF DIO) mice. The results revealed that some of these extracts could lower serum cholesterol levels in HF DIO mice. The same extracts were also parallelly analyzed by LC-MS in both positive and negative ionization modes. Based on the pharmacological results, 22 LC-MS variables were identified to be correlated with the anti-hyperlipidemic effects using partial least square discriminant analysis (PLS-DA) and independent samples t-test...
December 2, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29232588/bioactive-products-from-singlet-oxygen-photooxygenation-of-cannabinoids
#3
Ahmed Galal Osman, Khaled M Elokely, Vivek K Yadav, Paulo Carvalho, Mohamed Radwan, Desmond Slade, Waseem Gul, Shabana Khan, Olivia R Dale, Afeef S Husni, Michael L Klein, Stephen J Cutler, Samir A Ross, Mahmoud A ElSohly
Photooxygenation of Δ8 tetrahydrocannabinol (Δ8-THC), Δ9 tetrahydrocannabinol (Δ9-THC), Δ9 tetrahydrocannabinolic acid (Δ9-THCA) and some derivatives (acetate, tosylate and methyl ether) yielded 24 oxygenated derivatives, 18 of which were new and 6 were previously reported, including allyl alcohols, ethers, quinones, hydroperoxides, and epoxides. Testing these compounds for their modulatory effect on cannabinoid receptors CB1 and CB2 led to the identification of 7 and 21 as CB1 partial agonists with Ki values of 0...
November 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29231891/bioactive-compounds-produced-by-hypoxylon-fragiforme-against-staphylococcus-aureus-biofilms
#4
Kamila Tomoko Yuyama, Clara Chepkirui, Lucile Wendt, Diana Fortkamp, Marc Stadler, Wolf-Rainer Abraham
Treating infections organized in biofilms is a challenge due to the resistance of the pathogens against antibiotics and host immune cells. Many fungi grow in a wet environment, favorable for the growth of bacterial biofilms, and we speculated that fungi possess some strategies to control these bacterial biofilms. A fungus identified as Hypoxylon fragiforme, was collected in the Harz Mountains, Germany, and its mycelial culture was fermented in different culture media for 67 days to test its biological potential against bacterial biofilms...
December 12, 2017: Microorganisms
https://www.readbyqxmd.com/read/29231844/collismycin-c-from-the-micronesian-marine-bacterium-streptomyces-sp-mc025-inhibits-staphylococcus-aureus-biofilm-formation
#5
Jin-Hyung Lee, Eonmi Kim, Hyukjae Choi, Jintae Lee
Biofilm formation plays a critical role in antimicrobial resistance in Staphylococcus aureus. Here, we investigated the potential of crude extracts of 79 Micronesian marine microorganisms to inhibit S. aureus biofilm formation. An extract of Streptomyces sp. MC025 inhibited S. aureus biofilm formation. Bioactivity-guided isolation led to the isolation of a series of 2,2'-bipyridines: collismycin B (1), collismycin C (2), SF2738 D (3), SF2738 F (4), pyrisulfoxin A (5), and pyrisulfoxin B (6). Among these bipyridines, collismycin C (2) was found to be the most effective inhibitor of biofilm formation by methicillin-sensitive S...
December 12, 2017: Marine Drugs
https://www.readbyqxmd.com/read/29230827/occurrence-of-variable-levels-of-health-promoting-fruit-compounds-in-horn-shaped-italian-sweet-pepper-varieties-assessed-by-a-comprehensive-approach
#6
Giuseppe Mennella, Antonietta D'Alessandro, Gianluca Francese, Daniela Fontanella, Mario Parisi, Pasquale Tripodi
BACKGROUND: Cultivated pepper is a rich source of diverse bioactive compounds with potential properties related to the prevention of major degenerative and proliferative diseases. In the present study, 15 sweet pepper varieties highly appreciated on the Italian market, were assessed for variation in the content of ascorbic acid, isoprenoids, flavonoids, morpho-agronomic performances and molecular diversity. RESULTS: The collection under study showed a wide variability for all traits considered...
December 12, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29230816/how-grinding-levels-and-brewing-methods-espresso-american-turkish-could-affect-the-antioxidant-activity-and-bioactive-compounds-in-a-coffee-cup
#7
Antonio Derossi, Ilde Ricci, Rossella Caporizzi, Anna Fiore, Carla Severini
BACKGROUND: Depending on geographical origins and cultural traditions, different brewing procedures are used all over the world to prepare a coffee cup. In this work, we explored as three grinding levels of coffee powder and three coffee preparation methods such as by filtration (American), by boiling (Turkish) and by extraction under pressure (Espresso) affect healthy compounds and physicochemical attributes in coffee cup served to consumers. RESULTS: the grinding level slightly affects the quality of coffees, while the preparation methods significantly influenced all in-cup attributes...
December 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29230175/the-combined-use-of-in-silico-in-vitro-and-in-vivo-analyses-to-assess-anti-cancerous-potential-of-a-bioactive-compound-from-cyanobacterium-nostoc-sp-mgl001
#8
Niveshika, Ekta Verma, Shashank K Maurya, Rajnikant Mishra, Arun K Mishra
Escalating incidences of cancer, especially in developed and developing countries, demand evaluation of potential unexplored natural drug resources. Here, anticancer potential of 9-Ethyliminomethyl-12-(morpholin-4-ylmethoxy)-5,8,13,16-tetraaza -hexacene-2,3-dicarboxylic acid (EMTAHDCA) isolated from fresh water cyanobacterium Nostoc sp. MGL001 was screened through in silico, in vitro, and in vivo studies. For in silico analysis, EMTAHDCA was selected as ligand and 11 cancer related proteins (Protein Data Bank ID: 1BIX, 1NOW, 1TE6, 2RCW, 2UVL, 2VCJ, 3CRY, 3HQU, 3NMQ, 5P21, and 4B7P) which are common targets of various anticancer drugs were selected as receptors...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29230155/methodological-considerations-in-a-pilot-study-on-the-effects-of-a-berry-enriched-smoothie-on-children-s-performance-in-school
#9
Ulla Rosander, Kimmo Rumpunen, Viktoria Olsson, Mikael Åström, Pia Rosander, Karin Wendin
Berries contain bioactive compounds that may affect children's cognitive function positively, while hunger and thirst during lessons before lunch affect academic performance negatively. This pilot study addresses methodological challenges in studying if a berry smoothie, offered to schoolchildren as a mid-morning beverage, affects academic performance. The objective was to investigate if a cross-over design can be used to study these effects in a school setting. Therefore, in order to investigate assay sensitivity, 236 Swedish children aged 10-12 years were administered either a berry smoothie (active) or a fruit-based control beverage after their mid-morning break...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/29228818/evaluation-of-herbal-concoctions-sold-at-ga-maja-limpopo-province-in-south-africa-and-in-vitro-pharmacological-evaluation-of-plants-used-to-manufacture-the-concoctions
#10
Mash M Matotoka, Peter Masoko
The aim of the study was to evaluate the biological activities and safety of commercial herbal concoctions manufactured in Ga Maja (Limpopo province). Microbial contamination was evaluated by spread-plating the concoctions on agar plates. The VITEK 2 instrument was used for identification of the pure cultures. Nutritional content of the concoctions was determined. Thin layer chromatography was used to analyze the chemical constituents of the extracts. The microdilution assay and bioautography were used to evaluate antimicrobial activity against selected microorganisms...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/29227497/dietary-fruits-and-arthritis
#11
REVIEW
Arpita Basu, Jace Schell, R Hal Scofield
Arthritis is a global health concern affecting a significant proportion of the population and associated with reduced quality of life. Among the different forms of arthritis, osteoarthritis (OA) and rheumatoid arthritis (RA) are the most common and lacking a definite cure in the affected individuals. Fruits, such as berries and pomegranates are rich sources of a variety of dietary bioactive compounds, especially the polyphenolic flavonoids that have been associated with antioxidant, anti-inflammatory and analgesic effects...
December 11, 2017: Food & Function
https://www.readbyqxmd.com/read/29227203/therapeutic-charm-of-quercetin-and-its-derivatives-a-review-of-research-and-patents
#12
Ajay Sharma, Dharambir Kashyap, Katrin Sak, Hardeep Singh Tuli, Anil K Sharma
Bioactive polyphenolic compounds derived from plants are being utilized for prevention of various chronic diseases including cancer and cardiovascular disorders. Quercetin, a potential poly-phenolic flavonol, found in onions, apples and berries, has been implicated against cancer proliferation, chronic inflammation and various other oxidative manifestations. Evidences suggested that quercetin negatively regulates the numerous crucial signaling pathways associated with life-threatening diseases. Major signaling pathways including NF-κB, MAPK, PI3K-AKT and mTOR are found to be regulated by quercetin...
December 11, 2017: Pharmaceutical Patent Analyst
https://www.readbyqxmd.com/read/29227021/rapid-characterization-of-the-absorbed-chemical-constituents-of-tangzhiqing-formula-following-oral-administration-using-uhplc-q-tof-ms
#13
Xiao-Lei Wu, Ming-Jiang Wu, Xin-Ze Chen, Hong-Min Zhang, Li-Qin Ding, Fu-Ying Tian, Xiao-Meng Fu, Feng Qiu, De-Qin Zhang
Tangzhiqing formula, a Chinese herbal formula, is used for the treatment of type II diabetes and pre-diabetes. Although its effectiveness has been certified by clinical use, its absorbed chemical constituents are not comprehensively represented. Thence, to reveal potential bioactive components and metabolism of Tangzhiqing formula, an ultra high performance liquid chromatography with quadrupole time-of-flight mass spectrometry method was developed. A total of 86 absorbed components, including 38 prototype compounds and 48 metabolites, were identified in rat plasma, urine and feces after oral administration of Tangzhiqing formula...
December 11, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29226969/cudratricusxanthone-a-attenuates-sepsis-induced-liver-injury-via-sirt1-signaling
#14
Yuri Lee, Gil-Saeng Jeong, Wonhwa Lee, Jong-Sup Bae
Cudratricusxanthone A (CTXA), a natural bioactive compound extracted from the roots of Cudraniatricuspidata Bureau, is known to possess antithrombotic, antiproliferative and antiinflammatory activities. It remains unclear that CTXA can improve hepatoprotective activity in vivo. The objective of this study was to investigate the effect of CTXA on lipopolysaccharide (LPS)-induced liver failure in mice, and to elucidate its underlying molecular mechanisms. Liver failure was induced by LPS (15 mg/kg, i.p.) in mice, and 12 h later, they were treated intravenously with CTXA...
December 11, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29225119/d-chiro-inositol-enriched-fagopyrum-tataricum-l-gaench-extract-alleviates-mitochondrial-malfunction-and-inhibits-er-stress-jnk-associated-inflammation-in-the-endothelium
#15
Bobo Zhang, Caifeng Gao, Yunlong Li, Min Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Tartary buckwheat is a food medicine dual-use crop with healing effects on cardiovascular diseases and type2 diabetes. It has been proposed that endothelial dysfunction is the initial lesion in these diseases and it's associated with mitochondrial dysfunction, endoplasmic reticulum (ER) stress and inflammation. D-chiro-inositol (DCI) is a bioactive compound of Tartary buckwheat and is always deficit in type2 diabetes. However, it remains unknown whether DCI-enriched Tartary buckwheat extract can ameliorate mitochondrial dysfunction, ER stress and inflammation in the endothelium...
December 7, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29224736/a-natural-small-molecule-inhibitor-corilagin-blocks-hcv-replication-and-modulates-oxidative-stress-to-reduce-liver-damage
#16
B Uma Reddy, Ranajoy Mullick, Anuj Kumar, Geetika Sharma, Paromita Bag, Chaitrali Laha Roy, Govindarajan Sudha, Himani Tandon, Pratik Dave, Asutosh Shukla, Priyanka Srinivasan, Madhusudhan Nandhitha, Narayanaswamy Srinivasan, Saumitra Das
Hepatitis C virus (HCV) infection causes chronic liver disease, which often leads to hepatocellular carcinoma. Earlier, we have demonstrated anti-HCV property of the methanolic extract of Phyllanthus amarus, an age-old folk-medicine against viral hepatitis. Here, we report identification of a principal bioactive component 'corilagin', which showed significant inhibition of the HCV key enzymes, NS3 protease and NS5B RNA-dependent-RNA-polymerase. This pure compound could effectively inhibit viral replication in the infectious cell culture system, displayed strong antioxidant activity by blocking HCV induced generation of reactive oxygen species and suppressed up-regulation of NOX4 and TGF-β mRNA levels...
December 7, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29224370/authenticating-apple-cider-vinegar-s-home-remedy-claims-antibacterial-antifungal-antiviral-properties-and-cytotoxicity-aspect
#17
Judy Gopal, Vimala Anthonydhason, Manikandan Muthu, Enkhtaivan Gansukh, Somang Jung, Sechul Chul, Sivanesan Iyyakkannu
These are the days when one would go online first seeking home remedies before seeing a doctor. Apple cider vinegar (ACV) is one such popular yet scientifically under-validated remedy. Our results prove the unequivocal antimicrobial activity of ACV to be true at full strength concentrations. However, the activity cannot be generalised because although strong antibacterial activity was observed at 25% concentrations, in terms of antifungal activity, yeasts, especially Candida were found to be less susceptible...
December 11, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29224253/phytochemical-composition-and-biological-activities-of-dyssodia-tagetiflora-lag
#18
Ana María García-Bores, Amira Arciniegas-Arciniegas, Alma Reyna Campos, Carlos Céspedes-Acuña, Betsaida Avila-Suárez, Julio Alarcón-Enos, Saul Flores-Maya, Adriana Montserrat Espinosa-González, Alfonso Romo de Vivar-Romo, Carlos Pérez Plasencia, José Guillermo Avila-Acevedo
While plants of the genus Dyssodia are used by man to a certain extent, few phytochemical and pharmacological studies have been performed with species of this genus. D. tagetiflora is an endemic plant of Mexico and has been used as fodder. The aim of this research was to isolate and identify the main bioactive components and evaluate the insecticidal, antioxidant, genotoxic and cytoprotective activities of D. tagetiflora. The isolated substances included an essential oil composed of six monoterpenes, and extracts containing two flavonols, three flavonol-glycosides and four thiophenes...
December 10, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29223588/-9-o-%C3%AE-l-rhamnopyranosyl-lyoniresinol-from-lespedeza-cuneata-suppresses-ovarian-cancer-cell-proliferation-through-induction-of-apoptosis
#19
Jiwon Baek, Dahae Lee, Tae Kyoung Lee, Ji Hoon Song, Ju Sung Lee, Seong Lee, Sang-Woo Yoo, Ki Sung Kang, Eunjung Moon, Sanghyun Lee, Ki Hyun Kim
Lespedeza cuneata (Dum. Cours.) G. Don. (Fabaceae), known as Chinese bushclover or sericea lespedeza, has been used in traditional medicine to treat diabetes, hematuria, and insomnia, and it has been reported that bioactive compounds from L. cuneata possess various pharmacological properties. However, there has been no study to determine the active compounds from L. cuneata with potential activity against ovarian cancer. This study aimed to isolate cytotoxic compounds from L. cuneata and identify the molecular mechanisms underlying the apoptosis pathway in ovarian cancer cells...
November 28, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29223135/simultaneous-anti-diabetic-and-anti-vascular-calcification-activity-of-nocardia-sp-utmc-751
#20
Fatemeh Salimi, Saeedeh Jafari-Nodooshan, Nazanin Zohourian, Sedighe Kolivand, Javad Hamedi
Alpha-amylase can act as a significant player in causing hyperglycemia, leading to protein glycation, which is the main complication in this condition, besides causing vascular calcification (VC), an important vascular failure caused due to thisIn order to find a natural source of the biocompounds with inhibitory effects on alpha-amylase,, fifteen fermentation broth extracts of actinobacteria (FBEA) (200 μg mL-1 ) have been screened. Finally, the effects of the most efficient FBE have been investigated on osteopontin (OPN, a VC marker) mRNA level in the vascular smooth muscle cells under the calcification conditions, and the chemical constituents of the most efficient FBE were analyzed using GC-MS analysis...
December 9, 2017: Letters in Applied Microbiology
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