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https://www.readbyqxmd.com/read/29679507/novel-inhibitors-of-the-cellular-ras-components-poricoic-acids-target-smad3-phosphorylation-and-wnt-%C3%AE-catenin-pathway-against-renal-fibrosis
#1
Ming Wang, Dan-Qian Chen, Lin Chen, Gang Cao, Hui Zhao, Dan Liu, Nosratola D Vaziri, Yan Guo, Ying-Yong Zhao
BACKGROUND AND PURPOSE: Tubulo-interstitial fibrosis is the final pathway of progression of CKD to ESRD. Renin-angiotensin system (RAS) plays a major role in CKD progression. Present study demonstrates efficacy of the novel RAS inhibitors isolated from Poria cocos against renal fibrosis. EXPERIMENTAL APPROACH: The effect of three novel tetracyclic triterpenoid compounds poricoic acid ZC (PZC), poricoic acid ZD (PZD) and poricoic acid ZE (PZE) was investigated on TGF-β1- and angiotensin II (AngII)-treated HK-2 cells and UUO mice...
April 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29679266/changes-in-content-of-triterpenoids-and-polysaccharides-in-ganoderma-lingzhi-at-different-growth-stages
#2
Toshinori Nakagawa, Qinchang Zhu, Sonam Tamrakar, Yhiya Amen, Yasuhiro Mori, Hiroto Suhara, Shuhei Kaneko, Hiroko Kawashima, Kotaro Okuzono, Yoshiyuki Inoue, Koichiro Ohnuki, Kuniyoshi Shimizu
Ganoderma lingzhi is a traditional medicinal mushroom, and its extract contains many bioactive compounds. Triterpenoids and polysaccharides are the primary bioactive components that contribute to its medicinal properties. In this study, we quantified 18 triterpenoids, total triterpenoid content and total polysaccharide content in the ethanol and water extracts of G. lingzhi at different growth stages. Triterpenoids were quantified by liquid chromatograph-tandem mass spectrometry in the multiple-reaction-monitoring mode...
April 20, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29679028/radiosensitization-by-marine-sponge-agelas-sp-extracts-in-hepatocellular-carcinoma-cells-with-autophagy-induction
#3
Changhoon Choi, Arang Son, Hyi-Seung Lee, Yeon-Ju Lee, Hee Chul Park
Although radiation therapy is an effective treatment modality in many cancers, there is an urgent need to develop therapeutic drugs capable of overcoming radioresistance or minimizing normal tissue toxicity. A wide variety of marine-derived bioactive compounds have been screened for anti-cancer drug discovery, but little is known regarding radiation therapy applications. In this study, six different extracts of marine sponges collected from the Micronesian sea were screened for anti-cancer and radiosensitizing activity...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29677543/garcinia-morella-fruit-a-promising-source-of-antioxidant-and-anti-inflammatory-agents-induces-breast-cancer-cell-death-via-triggering-apoptotic-pathway
#4
Bhaswati Choudhury, Raghuram Kandimalla, R Elancheran, Rupjyoti Bharali, Jibon Kotoky
A rapid rise in cancer cases worldwide, especially breast cancer in females, instigates the need for more effective and less side effect causing drugs from natural origin. Thereby, in the present study, Garcinia morella fruit was investigated for antioxidant, anti-inflammatory and anti-breast cancer activity. Preliminary antioxidant and anticancer evaluation of different fractions and crude methanol extract of G. morella fruit suggested chloroform fraction as the bioactive fraction. Time course analysis (by 24 h, 48 h and 72 h) of the bioactive fraction (1...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29677459/hepatoprotective-and-antioxidant-properties-of-the-aqueous-extract-of-olea-europaea-leaves-against-diclofenac-induced-liver-damages-in-mice
#5
Rawya Soussi, Najla Hfaiedh, Fatma Guesmi, Mohsen Sakly, Khémais Ben Rhouma
Historically, olive tree "Olea europaea" is one of the most important fruit trees in Mediterranean countries. Several studies suggest that olive leaf is a significant source of bioactive phenolic compounds compared to olive oil and fruits. This study was undertaken to investigate, the protective effect of the aqueous extract of « Chemlali » olive leaves against diclofenac-induced damages in liver and haematological alterations in swiss albinos mice. For this, twenty-eight mice were divided into four groups: a control group, a diclofenac-treated group (2...
April 20, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29676912/bioactivity-guided-isolation-of-potential-antidiabetic-and-antihyperlipidemic-compounds-from-trigonella-stellata
#6
Safa M Shams Eldin, Mohamed M Radwan, Amira S Wanas, Abdel-Azim M Habib, Fahima F Kassem, Hala M Hammoda, Shabana I Khan, Michael L Klein, Khaled M Elokely, Mahmoud A ElSohly
The in vitro antidiabetic and antihyperlipidemic activities of an alcoholic extract of Trigonella stellata were evaluated in terms of the activation of PPARα and PPARγ in human hepatoma (HepG2) cells. The extract was investigated phytochemically, aiming at the isolation of the most active compounds to be used as a platform for drug discovery. Three new isoflavans, (3 S,4 R)-4,2',4'-trihydroxy)-7-methoxyisoflavan (1), (3 R,4 S)-4,2',4'-trihydroxy-7-methoxy-4'- O-β-d-glucopyranosylisoflavan (2), and (2 S,3 R,4 R)-4,2',4'-trihydroxy-2,7-dimethoxyisoflavan (3), were isolated and characterized along with the five known compounds p-hydroxybenzoic acid (4), 7,4'-dihydroxyflavone (5), dihydromelilotoside (6), quercetin-3,7- O-α-l-dirhamnoside (7), and soyasaponin I (8)...
April 20, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29676851/preparation-of-five-high-purity-iridoid-glycosides-from-gardenia-jasminoides-eills-by-molecularly-imprinted-solid-phase-extraction-integrated-with-preparative-liquid-chromatography
#7
Lizong Chen, Rongyu Wang, Li Cui, Xiao Wang, Leilei Wang, Fanyong Song, Wenhua Ji
Five iridoid glycosides were prepared using molecularly imprinted solid phase extraction combined with preparative high-performance liquid chromatography. Hydrophilic molecularly imprinted polymers were synthesized using α-1-allyl-2-N-acetyl glucosamine, which introduced an abundance of hydrophilic groups into the polymers. Using molecularly imprinted solid-phase extraction as the sample pretreatment procedure, five iridoid glycosides, gardenoside, geniposide, shanzhiside, geniposidic acid, and genipin-1-O-gentiobioside, were selectively enriched from Gardenia fructus extracts...
April 20, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29676822/site-selective-trans-hydrostannation-of-1-3-and-1-n-diynes-application-to-the-total-synthesis-of-typhonosides-e-and-f-and-a-fluorinated-cerebroside-analogue
#8
Alois Fürstner, Xiaobin Mo, Aurelien Letort, Dragos-Adrian Rosca, Kosuge Higashida
Propargyl alcohols are privileged substrates for stereochemically unorthodox trans-hydrostannation reactions catalyzed by [Cp*RuCl]4, because an incipient hydrogen bond between the -OH group and the polarized [RuCl] unit assists substrate binding. For this very reason it is also possible to subject diyne derivatives carrying one -OH group to site-selective stannylation, even if the acetylene units are conjugated and hence electronically coupled. An unusual temperature dependence was observed in that heating tends to improve site-selectivity, whereas per-stannylation is favored when the reaction is carried out in the cold...
April 20, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29676128/-quality-assessment-of-commercial-rosemary-based-on-liquid-gas-chromatography-and-mass-spectrography-with-multivariate-statistical-analysis
#9
Ji-Dan Zhang, Wei Guo, Yan Tang, Ai-Juan Shao, Bin Yang
A GC-MS fingerprint of rosemary oil and an UPLC fingerprint of non-volatile compounds of rosemary were established. Sixty-three kinds of volatile compounds and thirty-eight kinds of non-volatile compounds were identified tentatively using GC-MS and UPLC-Q-TOF-MS, respectively, and most of them are flavonoids, oxygenated monoterpenes, and diterpenoids, etc. According to multivariate data analysis, chemical differences existed among commercial rosemary samples, for example, the essential oil of imported rosemary sample belongs to Morocco/Tunisian type and the one of domestic sample belongs to Spanish type...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676099/-binding-interaction-of-harpagoside-and-bovine-serum-albumin-spectroscopic-methodologies-and-molecular-docking
#10
Tuan-Wu Cao, Wen-Bing Huang, Jian-Wei Shi, Wei He
Scrophularia ningpoensis has exhibited a variety of biological activities and been used as a pharmaceutical product for the treatment of inflammatory ailment, rheumatoid arthritis, osteoarthritis and so on. Harpagoside (HAR) is considerer as a main bioactive compound in this plant. Serum albumin has important physiological roles in transportation, distribution and metabolism of many endogenous and exogenous substances in body. It is of great significance to study the interaction mechanism between HAR and bovine serum albumin (BSA)...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676097/-quality-evaluation-of-artemisiae-argyi-folium-based-on-fingerprint-analysis-and-quantitative-analysis-of-multicomponents
#11
Long Guo, Qian Jiao, Dan Zhang, Ai-Peng Liu, Qian Wang, Yu-Guang Zheng
Artemisiae Argyi Folium, the dried leaves of Artemisia argyi, has been widely used in traditional Chinese and folk medicines for treatment of hemorrhage, pain, and skin itch. Phytochemical studies indicated that volatile oil, organic acid and flavonoids were the main bioactive components in Artemisiae Argyi Folium. Compared to the volatile compounds, the research of nonvolatile compounds in Artemisiae Argyi Folium are limited. In the present study, an accurate and reliable fingerprint approach was developed using HPLC for quality control of Artemisiae Argyi Folium...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676095/-chemical-constituents-from-roots-of-pieris-formosa-and-their-bioactivity
#12
Shu-Meng Xiao, Chang-Shan Niu, Yong Li, Zhi-Shu Tang, Jing Qu
By the means of chromatographic methods and spectroscopic evidences, 7 diterpenoids were isolated and identified from the roots of Pieris formosa. These known compounds are elucidated as secorhodomollolide C(1), pierisoid B (2), secorhodomollolide B (3), secorhodomollolide A (4), pierisformotoxin G (5), pierisformotoxin B (6) and pierisformotoxin A (7). Compounds 3, 4 were obtained from this plant for the first time. The analgesic activities of compounds 1-7 were evaluated using an acetic acidinduced writhing test in mice...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29676029/functionalized-spiroindolines-with-anticancer-activity-through-a-metal-free-post-ugi-diastereoselective-one-pot-cascade-reaction
#13
Zhi-Gang Xu, Shi-Qiang Li, Jiang-Ping Meng, Dian-Yong Tang, Liu-Jun He, Jie Lei, Hui-Kuan Lin, Hong-Yu Li, Zhong-Zhu Chen
A post-Ugi diastereoselective one-pot cascade reaction requiring no metal catalyst was developed. The reaction scope was wide with mild conditions and good yields. A collection of spiroindolines was prepared by the protocol and screening tests in several difficult-to-inhibit cancer cell lines were conducted. The relationship of structure and anticancer activities was promising and in the Huh7 cell lines compound 16 j is more potent than Vinbalstine. The cyclization design strategy could be applicable to other multicomponent reactions (MCRs) for synthesizing bioactive and drug-like heterocycles...
April 20, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29674143/bioactive-peptides-and-free-amino-acids-profiles-in-different-types-of-european-dry-fermented-sausages
#14
Marta Gallego, Leticia Mora, Elizabeth Escudero, Fidel Toldrá
A wide variety of dry-fermented sausages are produced in European countries, where are considered valued traditional products. An intense proteolysis takes place during the processing of dry-fermented sausages due to the combined action of muscle and microbial peptidases, generating large amounts of peptides and free amino acids. These compounds participate in the development of the characteristic flavor of dry-fermented products, but some peptides can also exert certain bioactivities such as antioxidant and ACE inhibitory activities...
April 5, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29674043/-1-h-nmr-and-antioxidant-profiles-of-polar-and-non-polar-extracts-of-persimmon-diospyros-kaki-l-metabolomics-study-based-on-cultivars-and-origins
#15
M Maulidiani, Ahmed Mediani, Faridah Abas, Yong Seo Park, Yang-Kyun Park, Young Mo Kim, Shela Gorinstein
Persimmon (Diospyros kaki L.) is one of the most important fruits that has been consumed for its medicinal properties due to the presence of some active metabolites, particularly polyphenols and carotenoids. Previously described methods, including HPLC, were limited in the determination of metabolites in different persimmon varieties. The present study shows the evaluation and the differences among persimmon polar and non-polar extracts by 1 H NMR-based metabolomics approach. The hierarchical clustering analysis (HCA) based on score values of principal component analysis (PCA) model was used to analyze the important compounds in investigated fruits...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29673988/sustainable-approach-in-phlorotannin-recovery-from-macroalgae
#16
Shir Reen Chia, Pau Loke Show, Siew-Moi Phang, Tau Chuan Ling, Hwai Chyuan Ong
In this present study, alcohol/salt liquid biphasic system was used to extract phlorotannin from brown macroalgae. Liquid biphasic system is a new green technology that integrated with various processes into one-step, by concentrating, separating and purifying the bioproduct in a unit operation. The solvent used is non-toxic and there is potential for solvent recovery which is beneficial to the environment. Phlorotannin is a bioactive compound that has gained much attention due to its health beneficial effect...
April 16, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29672974/inhibition-of-uvb-induced-pro-inflammatory-cytokines-and-mmp-expression-by-zanthoxylum-rhetsa-bark-extract-and-its-active-constituent-hesperidin
#17
Ramesh Kumar Santhanam, Sharida Fakurazi, Syahida Ahmad, Faridah Abas, Intan Safinar Ismail, Yaya Rukayadi, Muhammad Tayyab Akhtar, Khozirah Shaari
The antiphoto aging property of Zanthoxylum rhetsa obtained from Pangkor Island, Malaysia, was evaluated. Solvent fractions of different polarity obtained from the methanolic extract of the bark material were initially tested for anticollagenase and antielastase activities. The ethyl acetate fraction showed bioactivity against the protease enzymes. Hence, it was subjected to further purification via column chromatography, to yield a major constituent, hesperidin. Subsequently, the ethyl acetate fraction and hesperidin were tested for their effects against UVB-induced cytotoxicity and expressions of inflammatory cytokines (IL-6, IL-1β, and TNF-α), NF-κB, and MMPs (MMP1, 3, and 9) in human dermal fibroblasts (HDF)...
April 19, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29672820/a-review-of-the-toxicity-of-compounds-found-in-herbal-dietary-supplements
#18
Amy Hudson, Elizabeth Lopez, Ahmad J Almalki, Amy L Roe, Angela I Calderón
Use of herbal dietary supplements by the public is common and has been happening for centuries. In the United States, the Food and Drug Administration has a limited scope of regulation over marketed herbal dietary supplements, which may contain toxic botanical compounds that pose a public health risk. While the Food and Drug Administration has made efforts to prohibit the sale of unsafe herbal dietary supplements, numerous reports have proliferated of adverse events due to these supplements. This literature review investigates bioactive plant compounds commonly used in herbal dietary supplements and their relative toxicities...
April 19, 2018: Planta Medica
https://www.readbyqxmd.com/read/29672015/zebrafish-based-discovery-of-antiseizure-compounds-from-the-red-sea-pseurotin-a-2-and-azaspirofuran-a
#19
Daniëlle Copmans, Mostafa Rateb, Jioji N Tabudravu, Mercedes Pérez-Bonilla, Nina Dirkx, Riccardo Vallorani, Caridad Diaz, José Pérez Del Palacio, Alan J Smith, Rainer Ebel, Fernando Reyes, Marcel Jaspars, Peter A M de Witte
In search for novel antiseizure drugs (ASDs), the European FP7-funded PharmaSea project used zebrafish embryos and larvae as a drug discovery platform to screen marine natural products to identify promising antiseizure hits in vivo for further development. Within the framework of this project, seven known heterospirocyclic γ-lactams, namely, pseurotin A, pseurotin A2 , pseurotin F1, 11- O-methylpseurotin A, pseurotin D, azaspirofuran A, and azaspirofuran B, were isolated from the bioactive marine fungus Aspergillus fumigatus, and their antiseizure activity was evaluated in the larval zebrafish pentylenetetrazole (PTZ) seizure model...
April 19, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29671173/cornus-mas-l-fruit-as-a-potential-source-of-natural-health-promoting-compounds-physico-chemical-characterisation-of-bioactive-components
#20
Marta De Biaggi, Dario Donno, Maria Gabriella Mellano, Isidoro Riondato, Ernest N Rakotoniaina, Gabriele L Beccaro
Interest in new sources of anti-inflammatory and antioxidant compounds has recently become a major research issue, with the cornelian cherry (Cornus mas L.) receiving particular attention for its significant amounts of phenolic compounds and vitamins, which exhibit a wide range of biological and pharmacological properties. This study was aimed at increasing knowledge regarding the cornelian cherry in Italy through the analysis of biologically active substances in the locally available genotype "Chieri"...
April 19, 2018: Plant Foods for Human Nutrition
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