keyword
MENU ▼
Read by QxMD icon Read
search

Bioactive compound

keyword
https://www.readbyqxmd.com/read/27933644/quantitative-determination-and-evaluation-of-paris-polyphylla-var-yunnanensis-with-different-harvesting-time-using-uplc-uv-ms-and-ft-ir-spectroscopy-in-combination-with-partial-least-squares-discriminant-analysis
#1
Yuan-Gui Yang, Ji Zhang, Yan-Li Zhao, Jin-Yu Zhang, Yuan-Zhong Wang
A rapid method was developed and validated by ultra performance liquid chromatography-triple quadrupole mass spectroscopy with ultraviolet detection (UPLC-UV-MS) for simultaneous determination of paris saponin I, paris saponin II, paris saponin VI and paris saponin VII. Partial least squares discriminant analysis (PLS-DA) based on UPLC and Fourier transform infrared (FT-IR) spectroscopy was employed to evaluate Paris polyphylla var. yunnanensis (PPY) of different harvesting time. Quantitative determination implied that the various content of bioactive compounds with different harvesting time may lead to different pharmacological effects, the average content of total saponins for PPY from eight years was higher than that from others...
December 9, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27933244/a-study-on-biological-activity-of-marine-fungi-from-different-habitats-in-coastal-regions
#2
Songlin Zhou, Min Wang, Qi Feng, Yingying Lin, Huange Zhao
In recent years, marine fungi have become an important source of active marine natural products. Former researches are limited in habitats selection of fungi with bioactive compounds. In this paper were to measure antibacterial and antitumor cell activity for secondary metabolites of marine fungi, which were isolated from different habitats in coastal regions. 195 strains of marine fungi were isolated and purified from three different habitats. They biologically active experiment results showed that fungi isolation from the mangrove habitats had stronger antibacterial activity than others, and the stains isolated from the estuarial habitats had the least antibacterial activity...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27932083/room-temperature-ionic-liquids-based-salting-in-strategy-for-counter-current-chromatography-in-the-separation-of-arctiin
#3
Yanyan Wang, Lihong Zhang, Dingding Wang, Xiuyun Guo, Shihua Wu
Counter-current chromatography (CCC) is a solid support-free liquid-liquid partition chromatography and has wide applications. However, CCC separation is still a challenging process and the selection of appropriate solvent system for separation of target compound(s) is still relatively time-consuming. In this work, we introduced a room temperature ionic liquids-based salting-in strategy for the rapid selection of suitable solvent systems for CCC separation. In the randomly selected solvent systems, such as ethyl acetate-water, n-butanol-water, n-pentanol-water, n-hexanol-water, and n-octanol-water, several ionic liquids such as [AMIM]Cl, [MAMIM]Cl, and [BMIM]Cl can increase the solubility of the solutes in the lower phase, which made a dose-dependent decreasing of partition coefficient of solute in the two-phase solvent system...
November 30, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27931126/%C3%AE-tocopherol-%C3%AE-carotene-lutein-squalene-and-secoiridoids-in-seven-monocultivar-italian-extra-virgin-olive-oils
#4
Roberto Ambra, Fausta Natella, Sabrina Lucchetti, Valentina Forte, Gianni Pastore
Fatty acids and bioactive lipophilic and hydrophilic compounds (tocopherols, β-carotene, lutein, squalene, total polyphenols and secoiridoids) in monocultivar Italian extra-virgin olive oil (EVOO) samples produced from the Leccino cultivar and six other yet uncharacterised cultivars (Rustica, Carpinetana, Dritta, Gentile di Chieti and Intosso) were analysed, also taking into account the effect of the type of decanter used for the oil extraction. Significant differences among cultivars were found for α-tocopherol and squalene, but not for carotenoids...
December 8, 2016: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/27930886/histone-adduction-and-its-functional-impact-on-epigenetics
#5
James J Galligan, Lawrence J Marnett
Bioactive electrophiles generated from the oxidation of endogenous and exogenous compounds are a contributing factor in numerous disease states. Their toxicity is largely attributed to the covalent modification of cellular nucleophiles, including protein and DNA. With regard to protein modification, the side-chains of Cys, His, Lys, and Arg residues are critical targets. This results in the generation of undesired protein post-translational modifications (PTMs), that can trigger dire cellular consequences. Notably, histones are Lys- and Arg-rich proteins, providing a fertile source for adduction by both exogenous and endogenous electrophiles...
December 8, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27929444/using-light-microscopy-and-liquid-chromatography-tandem-mass-spectrometry-for-qualitative-and-quantitative-control-of-a-combined-three-herb-formulation-in-different-preparations
#6
Tun-Pin Hsueh, Wan-Ling Lin, Tung-Hu Tsai
Artemisia capillaries Thunb, Gardenia jasminoides Ellis, and Rheum officinale Baill have been combined to treat jaundice for thousands of years. Studies have revealed that these herbs induce anti-hepatic fibrosis and anti-hepatic apoptosis and alleviate hepatic oxidative stress. This study aims to determine the quality and quantity of an herbal formulation (Chinese name: Yin-Chen-Hao-Tang) using physical and chemical examinations. Physical examination of Yin-Chen-Hao-Tang in pharmaceutical herbal products, raw fiber powders, and decoction preparations was performed using Congo red and iodine-potassium staining...
December 6, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27929431/internet-databases-of-the-properties-enzymatic-reactions-and-metabolism-of-small-molecules-search-options-and-applications-in-food-science
#7
REVIEW
Piotr Minkiewicz, Małgorzata Darewicz, Anna Iwaniak, Justyna Bucholska, Piotr Starowicz, Emilia Czyrko
Internet databases of small molecules, their enzymatic reactions, and metabolism have emerged as useful tools in food science. Database searching is also introduced as part of chemistry or enzymology courses for food technology students. Such resources support the search for information about single compounds and facilitate the introduction of secondary analyses of large datasets. Information can be retrieved from databases by searching for the compound name or structure, annotating with the help of chemical codes or drawn using molecule editing software...
December 6, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27929430/biological-activities-of-extracts-from-loquat-eriobotrya-japonica-lindl-a-review
#8
REVIEW
Yilong Liu, Wenna Zhang, Changjie Xu, Xian Li
Loquat (Eriobotrya japonica Lindl.) is a subtropical fruit tree with high medicinal value native to China. Different organs of loquat have been used historically as folk medicines and this has been recorded in Chinese history for thousands of years. Research shows that loquat extracts contain many antioxidants, and different extracts exhibit bioactivity capable of counteracting inflammation, diabetes, cancer, bacterial infection, aging, pain, allergy and other health issues. Bioactive compounds such as phenolics and terpenoids have been isolated and characterized to provide a better understanding of the chemical mechanisms underlying the biological activities of loquat extracts...
December 6, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27929402/extraction-and-quantification-of-bioactive-tyrian-purple-precursors-a-comparative-and-validation-study-from-the-hypobranchial-gland-of-a-muricid-dicathais-orbita
#9
Roselyn Valles-Regino, Peter Mouatt, David Rudd, Lachlan H Yee, Kirsten Benkendorff
Muricidae are marine molluscs known for the production of Tyrian purple and bioactive precursor compounds. A validation study for the extraction and analysis of secondary metabolites found in the hypobranchial gland of the muricid Dicathais orbita is reported, using high performance liquid chromatography-mass spectrometry (HPLC-MS) with diode array detector (DAD). Quantification of the dominant secondary metabolites from D. orbita is described, followed by a comparison of solvent extraction procedures and stability studies...
December 5, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27929185/melatonin-and-hydroxytyrosol-protect-against-oxidative-stress-related-to-the-central-nervous-system-after-the-ingestion-of-three-types-of-wine-by-healthy-volunteers
#10
Javier Marhuenda, Sonia Medina, Pedro Martínez-Hernández, Simón Arina, Pilar Zafrilla, Juana Mulero, Camille Oger, Jean-Marie Galano, Thierry Durand, Federico Ferreres, Angel Gil-Izquierdo
Adrenic acid (AdA) and docosahexaenoic acid (DHA) peroxidation produces F2-dihomo-IsoPs and neuroprostanes, which have been related to oxidative damage in the central nervous system. Besides polyphenols, melatonin (MEL) and hydroxytyrosol (OHTyr) could be partly responsible for the antioxidant benefits of red wine (excluding colon derivatives). In order to elucidate whether these compounds are responsible for the protective antioxidant effects of red wine, a double-blind, crossover, placebo-controlled in vivo study - involving the intake of red wines and their native musts by healthy volunteers - was performed...
December 8, 2016: Food & Function
https://www.readbyqxmd.com/read/27928751/laboratory-assessment-of-bioleaching-of-shallow-eutrophic-sediment-by-immobilized-photosynthetic-bacteria
#11
Shiyong Sun, Shenglan Fan, Kexuan Shen, Shen Lin, Xiaoqin Nie, Mingxue Liu, Faqin Dong, Jian Li
Eutrophic sediment is a serious problem in ecosystem restoration, especially in shallow lake ecosystems. We present a novel bioleaching approach to treat shallow eutrophic sediment with the objective of preventing the release of nitrate, phosphate, and organic compounds from the sediment to the water column, using porous mineral-immobilized photosynthetic bacteria (PSB). Bioactivity of bacteria was maintained during the immobilization process. Immobilized PSB beads were directly deposited on the sediment surface...
December 7, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27928710/synthesis-characterization-and-bioactivity-studies-of-novel-1-3-4-oxadiazole-small-molecule-that-targets-basic-phospholipase-a2-from-vipera-russelli
#12
Vivek Hamse Kameshwar, Kumar J R, Babu S Priya, S Nanjunda Swamy
Secretory phospholipase A2 (sPLA2) is a key enzyme participating in the inflammatory cascade followed by the action of cyclooxygenase-2 and lipoxygenases. Therefore, inhibitors of sPLA2 could be used as potent anti-inflammatory agents to treat the early phase of inflammation. In this study, we have prepared the fenoprofen and ibuprofen analogs containing 1,3,4-oxadiazole nucleus and tested against Vipera russelli venom's basic sPLA2 (VRV-PL-VIIIa). Among the tested ligands 5(a-t),2-(2-chlorophenyl)-5-(1-(4-phenoxyphenyl) ethyl)-1,3,4-oxadiazole (5m) inhibited the catalytic activity of VRV-PL-VIIIa with an IC50 value of 11...
December 7, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27927071/investigation-on-evaluation-criteria-of-backwashing-effects-for-a-pilot-scale-baf-treating-petrochemical-wastewater
#13
Liya Fu, Changyong Wu, Yuexi Zhou, Jiane Zuo, Yan Ding
Parameters for evaluation criteria of air-water backwashing effects of a pilot-scale biological aerated filter (BAF) treating petrochemical wastewater were investigated. The parameters included the suspended solids (SS) and specific oxygen uptake rate (SOUR) of the backwashing effluent, recovery of the BAF after backwashing, and the removal of the biomass/bioactivity attached on the filter media after backwashing. Results showed that the weight of the total sludge produced in the backwashing effluent increased with the increase of water-backwashing intensity, while the total SOUR of backwashing effluent rose notably with the increase of air-backwashing intensity...
December 7, 2016: Environmental Technology
https://www.readbyqxmd.com/read/27926533/andrographolide-impedes-cancer-stemness-and-enhances-radio-sensitivity-in-oral-carcinomas-via-mir-218-activation
#14
Po-Yu Yang, Pei-Ling Hsieh, Tong Hong Wang, Cheng-Chia Yu, Ming-Yi Lu, Yi-Wen Liao, Tzu-Hsin Lee, Chih-Yu Peng
Current evidence suggests that oral cancer stem cells (OCSCs) possess high tumorigenic and metastatic properties as well as chemo- and radioresistance. In this study, we demonstrated that andrographolide, the main bioactive component in the medicinal plant Andrographis, significantly reduced oncogenicity and restored radio-sensitivity of ALDH1+CD44+ OCSCs. Mechanistic studies showed that andrographolide treatment increased the expression of microRNA-218 (miR-218), leading to the downregulation of Bmi1. We showed that knockdown of miR-218 in ALDH1-CD44- non-OCSCs enhanced cancer stemness, while silencing of Bmi1 significantly counteracted it...
December 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27925266/marine-mollusk-derived-agents-with-antiproliferative-activity-as-promising-anticancer-agents-to-overcome-chemotherapy-resistance
#15
REVIEW
Maria Letizia Ciavatta, Florence Lefranc, Marianna Carbone, Ernesto Mollo, Margherita Gavagnin, Tania Betancourt, Ramesh Dasari, Alexander Kornienko, Robert Kiss
The chemical investigation of marine mollusks has led to the isolation of a wide variety of bioactive metabolites, which evolved in marine organisms as favorable adaptations to survive in different environments. Most of them are derived from food sources, but they can be also biosynthesized de novo by the mollusks themselves, or produced by symbionts. Consequently, the isolated compounds cannot be strictly considered as "chemotaxonomic markers" for the different molluscan species. However, the chemical investigation of this phylum has provided many compounds of interest as potential anticancer drugs that assume particular importance in the light of the growing literature on cancer biology and chemotherapy...
December 7, 2016: Medicinal Research Reviews
https://www.readbyqxmd.com/read/27925210/effects-of-steam-microwave-blanching-and-different-drying-processes-on-drying-characteristics-and-quality-attributes-of-thunbergia-laurifolia-linn-leaves
#16
Traiphop Phahom, Singhanat Phoungchandang, William L Kerr
BACKGROUND: Dried Thunbergia laurifolia leaves are usually prepared using tray drying, resulting in products that have lost substantial amounts of bioactive compounds and antioxidant activity. The maturity of the raw material, blanching techniques and drying methods were investigated in order to select the best condition to produce high qualities of dried T. laurifolia leaves. RESULTS: The 1(st) stage of maturity was selected and steam-microwave blanching (SMB) for 4 min was adequate for blanching leading to the maximum recovery of bioactive compounds...
December 7, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27925067/piper-aduncum-against-haemonchus-contortus-isolates-cross-resistance-and-the-research-of-natural-bioactive-compounds
#17
Yousmel Alemán Gaínza, Rafaela Regina Fantatto, Francisco Celio Maia Chaves, Humberto Ribeiro Bizzo, Sérgio Novita Esteves, Ana Carolina de Souza Chagas
The anthelminthic activity of the essential oil (EO) of Piper aduncum L. was tested in vitro on eggs and larvae of resistant (Embrapa2010) and susceptible (McMaster) isolates of Haemonchus contortus. The EO was obtained by steam distillation and its components identified by chromatography. EO concentrations of 12.5 to 0.02 mg/mL were used in the egg hatch test (EHT) and concentrations of 3.12 to 0.01 mg/mL in the larval development test (LDT). Inhibition concentrations (IC) were determined by the SAS Probit procedure, and significant differences assessed by ANOVA followed by Tukey's test...
December 1, 2016: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/27924727/metabolomics-of-healthy-berry-fruits
#18
Gilda D Urso, Sonia Piacente, Cosimo Pizza, Paola Montoro
The consumption of berry-type fruits has become very popular in recent years because of their positive effects on human health. Berries are in fact widely known for their health-promoting benefits, including prevention of chronic disease, cardiovascular disease and cancer. Berries are a rich source of bioactive metabolites, such as vitamins, minerals, and phenolic compounds, mainly anthocyanins. Numerous in vitro and in vivo studies recognized the health effects of berries and their function as bioactive modulators of various cell functions associated with oxidative stress...
December 5, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27924400/an-insight-into-the-secondary-metabolism-of-muscodor-yucatanensis-small-molecule-epigenetic-modifiers-induce-expression-of-secondary-metabolism-related-genes-and-production-of-new-metabolites-in-the-endophyte
#19
Masroor Qadri, Yedukondalu Nalli, Shreyans K Jain, Asha Chaubey, Asif Ali, Gary A Strobel, Ram A Vishwakarma, Syed Riyaz-Ul-Hassan
Muscodor spp. are proficient producers of bioactive volatile organic compounds (VOCs) with many potential applications. However, all members of this genus produce varying amounts and types of VOCs which suggests the involvement of epigenetics as a possible explanation. The members of this genus are poorly explored for the production of soluble compounds (extrolites). In this study, the polyketide synthase (PKS) and non-ribosomal peptide synthetase (NRPS) genes from an endophyte, Muscodor yucatanensis Ni30, were cloned and sequenced...
December 6, 2016: Microbial Ecology
https://www.readbyqxmd.com/read/27924032/the-antismash-database-a-comprehensive-database-of-microbial-secondary-metabolite-biosynthetic-gene-clusters
#20
Kai Blin, Marnix H Medema, Renzo Kottmann, Sang Yup Lee, Tilmann Weber
Secondary metabolites produced by microorganisms are the main source of bioactive compounds that are in use as antimicrobial and anticancer drugs, fungicides, herbicides and pesticides. In the last decade, the increasing availability of microbial genomes has established genome mining as a very important method for the identification of their biosynthetic gene clusters (BGCs). One of the most popular tools for this task is antiSMASH. However, so far, antiSMASH is limited to de novo computing results for user-submitted genomes and only partially connects these with BGCs from other organisms...
October 24, 2016: Nucleic Acids Research
keyword
keyword
99418
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"