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https://www.readbyqxmd.com/read/28239870/genotype-by-environment-effect-on-bioactive-compounds-in-strawberry-fragaria-x-ananassa-duch
#1
Luisa Palmieri, Domenico Masuero, Paolo Martinatti, Giuseppe Baratto, Stefan Martens, Urska Vrhovsek
BACKGROUND: The relative contribute assessment of the genotype, the environment and the genotype-by-environmental (G x E) interaction to the variety performance is necessary to determine their adaptation capacity. RESULTS: The influence of temperature, UV-irradiation and sunshine duration on quality and fruits composition was investigated in nine strawberry cultivars grown at three different altitudes. The UV-radiation intensity affected the pH and the sugar content that were higher for most of the varieties at low altitudes where the total titratable acidity (TTA) was less...
February 27, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28239443/enantioselective-convergent-synthesis-of-the-ineleganolide-core-by-a-tandem-annulation-cascade
#2
Robert A Craig, Jennifer L Roizen, Russell C Smith, Amanda C Jones, Scott C Virgil, Brian M Stoltz
An enantioselective and diastereoselective approach toward the synthesis of the polycyclic norditerpenoid ineleganolide is disclosed. A palladium-catalyzed enantioselective allylic alkylation is employed to stereoselectively construct the requisite chiral tertiary ether and facilitate the synthesis of a 1,3-cis-cyclopentenediol building block. Careful substrate design enabled the convergent assembly of the ineleganolide [6,7,5,5]-tetracyclic scaffold by a diastereoselective cyclopropanation-Cope rearrangement cascade under unusually mild conditions...
January 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28239352/celastrol-attenuates-multiple-sclerosis-and-optic-neuritis-in-an-experimental-autoimmune-encephalomyelitis-model
#3
Hongbin Yang, Chang Liu, Jie Jiang, Yuena Wang, Xiaoyu Zhang
This study was aimed to evaluate the effects of celastrol, a natural compound with multiple bioactivities, on multiple sclerosis and optic neuritis (ON) in rat experimental autoimmune encephalomyelitis (EAE). EAE was induced in Sprague Dawley rats using myelin basic protein, and the animals received daily intraperitoneal injections of celastrol or vehicle for 13 days. The EAE rats showed abnormal neurobehavior and inflammatory infiltration and demyelination in the spinal cord. Significantly upregulated mRNA expression of pro-inflammatory cytokines interferon-γ and interleukin-17 and downregulated anti-inflammatory cytokines interleukin-4 were found in the spinal cord of EAE rats...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28238042/entotheonella-bacteria-as-source-of-sponge-derived-natural-products-opportunities-for-biotechnological-production
#4
Agneya Bhushan, Eike E Peters, Jörn Piel
Marine sponges belong to the oldest animals existing today. Apart from their role in recycling of carbon and nitrogen in the ocean, they are also an important source of a wide variety of structurally diverse bioactive natural products. Over the past few decades, a multitude of compounds from sponges have been discovered exhibiting diverse, pharmacologically promising activities. However, in many cases the low substance quantities present in the sponge tissue would require the collection of large amounts of sponge material, thus impeding further drug development...
2017: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/28238038/bluegenics-bioactive-natural-products-of-medicinal-relevance-and-approaches-to-their-diversification
#5
Joseph S Zarins-Tutt, Emily R Abraham, Christopher S Bailey, Rebecca J M Goss
Nature provides a valuable resource of medicinally relevant compounds, with many antimicrobial and antitumor agents entering clinical trials being derived from natural products. The generation of analogues of these bioactive natural products is important in order to gain a greater understanding of structure activity relationships; probing the mechanism of action, as well as to optimise the natural product's bioactivity and bioavailability. This chapter critically examines different approaches to generating natural products and their analogues, exploring the way in which synthetic and biosynthetic approaches may be blended together to enable expeditious access to new designer natural products...
2017: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/28238035/major-antimicrobial-representatives-from-marine-sponges-and-or-their-associated-bacteria
#6
Fei He, Linh H Mai, Johan Gardères, Amjad Hussain, Vesna Erakovic Haber, Marie-Lise Bourguet-Kondracki
The rapid emergence of resistant bacteria during the last 20 years has stimulated research efforts in order to overcome this thorny problem. Marine sponges and their associated bacteria, which have been proven to be a source of bioactive natural products, have appeared as a promising opportunity to identify new antibiotic compounds. An overview of the major antibacterial compounds isolated from marine sponges and/or their associated bacteria is presented in this chapter, highlighting new potential antibiotics...
2017: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/28238034/35-years-of-marine-natural-product-research-in-sweden-cool-molecules-and-models-from-cold-waters
#7
Lars Bohlin, Paco Cárdenas, Anders Backlund, Ulf Göransson
Currents efforts in marine biodiscovery have essentially focused on temperate to tropical shallow water organisms. With more than 6000 species of marine plants and animals, the Kosterfjord area has the richest marine biodiversity in Swedish waters, but it remains understudied. The overall objective of our marine pharmacognosy research is to explore and reveal the pharmacological potential of organisms from this poorly explored region. More generally, we wish to understand aspects of structure-activity relationships of chemical interactions in cold-water marine environment (shallow and deep)...
2017: Progress in Molecular and Subcellular Biology
https://www.readbyqxmd.com/read/28237731/rhenium-i-tricarbonyl-compounds-of-bioactive-thiosemicarbazones-synthesis-characterization-and-activity-against-trypanosoma-cruzi
#8
Esteban Rodríguez Arce, Ignacio Machado, Belén Rodríguez, Michel Lapier, María Carolina Zúñiga, Juan Diego Maya, Claudio Olea Azar, Lucía Otero, Dinorah Gambino
American Trypanosomiasis is a chronic infection discovered and described in 1909 by the Brazilian scientist Carlos Chagas. It is caused by the protozoan parasite Trypanosoma cruzi. Although it affects about 10million people in Latin America, the current chemotherapy is still inadequate. The discovery of new drugs is urgently needed. Our group is focused on the development of prospective metal-based drugs mainly based on bioactive ligands and pharmacologically interesting metal ions. In this work three new rhenium(I) tricarbonyl compounds fac-[Re(I)(CO)3Br(HL)] where HL=5-nitrofuryl containing thiosemicarbazones were synthesized and fully characterized in solution and in the solid state...
January 23, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28237662/the-derivatives-of-pulsatilla-saponin-a-a-bioactive-compound-from-pulsatilla-chinensis-their-synthesis-cytotoxicity-haemolytic-toxicity-and-mechanism-of-action
#9
Xiaohang Tong, Li Han, Huaqing Duan, Yaru Cui, Yulin Feng, Yongming Zhu, Zhong Chen, Shilin Yang
The strong haemolytic toxicity of Pulsatilla saponin A (PSA) has hampered its clinical development as an injectable anticancer agent. To circumvent this challenge, twenty PSA derivatives with C ring or C-28 or C-3 modifications were synthesized and evaluated for cytotoxicity against seven selected human tumor lines, as well as for haemolytic toxicity. Structure-activity relationship (SAR) and structure-toxicity relationship (STR) correlations were also elucidated. Compared with PSA, compound 22 showed a better balance between haemolytic toxicity (HD50 > 500 μM) and cytotoxicity toward lung cancer cells A549 (IC50 = 4...
February 15, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28237087/e-configuration-structures-of-epa-and-dha-derived-from-euphausia-superba-and-their-significant-inhibitive-effects-on-growth-of-human-cancer-cell-lines-in-vitro
#10
Weilong Zheng, Xudong Wang, Wenjing Cao, Bowen Yang, Ying Mu, Yuesheng Dong, Zhilong Xiu
Many bioactive components such as poly-unsaturated fatty acids (e.g. EPA and DHA), phospholipids and astaxanthin are known in Antarctic krill (Euphausia superba) oil. The krill DHA and EPA are generally considered to be similar to natural ones. However, two chemical compounds which were separated from Antarctic krill oil and identified as EPA and DHA by HRESIMS and NMR acted much more effective inhibitive activities on growth of several cell lines (U937, K562, SMMC-7721, PC-3, MDA-MB-231, HL60 and MCF-7) than those from sturgeon liver and commercial fish oil...
February 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28235578/therapeutic-applications-of-thyroid-hormone-analogues-in-resistance-to-thyroid-hormone-rth-syndromes
#11
Stefan Groeneweg, Robin P Peeters, Theo J Visser, W Edward Visser
Thyroid hormone (TH) is crucial for normal development and metabolism of virtually all tissues. TH signaling is predominantly mediated through binding of the bioactive hormone 3,3',5-triiodothyronine (T3) to the nuclear T3-receptors (TRs). The intracellular TH levels are importantly regulated by transporter proteins that facilitate the transport of TH across the cell membrane and by the three deiodinating enzymes. Defects at the level of the TRs, deiodinases and transporter proteins result in resistance to thyroid hormone (RTH) syndromes...
February 21, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28235427/efficient-t3p-%C3%A2-mediated-synthesis-differential-cytotoxicity-and-apoptosis-induction-by-indolo-triazolo-thiadiazoles-in-human-breast-adenocarcinoma-cells
#12
Pooja R Kamath, Dhanya Sunil, Shubhankar Das, Abdul A Ajees, B S Satish Rao
The limited efficacy of marketed anticancer agents demands the design of novel target-specific hybrid molecules incorporating multiple bioactive pharmacores to combat cancer. In the present study, a one-pot simple and efficient T3P(®) mediated procedure for the preparation of twelve new 3-(substituted- [1,2,4]triazolo[3,4-b] [1,3,4]thiadiazolo)-1H-indoles with short reaction times, easy workup procedure, good yields, and purity of products is described. Cytotoxicity assay (MTT), flow-cytometric univariate cell cycle analysis, Annexin V-FITC staining and DNA fragmentation for cell death mechanism suggested that compound 3d with chloro-substituted phenyl ring induced enhanced cytotoxicity by an apoptotic pathway with high differential toxicity to breast adenocarcinoma cells (MCF-7) when compared with normal human dermal fibroblast cells...
February 21, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28231532/paeonifiorin-sulfonate-as-a-characteristic-marker-for-specifically-inspecting-chinese-patent-medicine-liu-wei-di-huang-wan-contained-sulfur-fumigated-moutan-cortex
#13
Xiu-Yang Li, Fang Long, Jin-Di Xu, Hong Shen, Ming Kong, He Zhu, Ye-Qing Zhang, Song-Lin Li
Sulfur fumigation can induce chemical transformation of bioactive components, consequently the alteration of bioactivities or even toxicities of medicinal herbs. Inspecting Chinese patent medicines (CPM) contained sulfur-fumigated constituent herbs is crucial for ensuring the safety and efficacy of CPM. Paeonifiorin sulfonate is a sulfur-fumigation induced compound of Moutan Cortex (MC), one of the main constituent herbs of a commonly used CPM Liu-Wei-Di-Huang-Wan (LWDHW). Herein, we investigated the approach of paeonifiorin sulfonate as a characteristic marker for specifically inspecting LWDHW potentially contained sulfur-fumigated MC (SFMC)...
February 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28231175/mushroom-polysaccharides-chemistry-and-antiobesity-antidiabetes-anticancer-and-antibiotic-properties-in-cells-rodents-and-humans
#14
REVIEW
Mendel Friedman
More than 2000 species of edible and/or medicinal mushrooms have been identified to date, many of which are widely consumed, stimulating much research on their health-promoting properties. These properties are associated with bioactive compounds produced by the mushrooms, including polysaccharides. Although β-glucans (homopolysaccharides) are believed to be the major bioactive polysaccharides of mushrooms, other types of mushroom polysaccharides (heteropolysaccharides) also possess biological properties. Here we survey the chemistry of such health-promoting polysaccharides and their reported antiobesity and antidiabetic properties as well as selected anticarcinogenic, antimicrobial, and antiviral effects that demonstrate their multiple health-promoting potential...
November 29, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231150/enhancing-the-total-phenolic-content-and-antioxidants-of-lemon-pomace-aqueous-extracts-by-applying-uv-c-irradiation-to-the-dried-powder
#15
Konstantinos Papoutsis, Quan V Vuong, Penta Pristijono, John B Golding, Michael C Bowyer, Christopher J Scarlett, Costas E Stathopoulos
Several studies have shown that UV-C (ultraviolet C) irradiation promotes the bioactive compounds and antioxidants of fresh fruits and vegetables. The aim of this study was to apply UV irradiation in dried lemon pomace powder for enhancing its phenolic content and antioxidant properties, thus more bioactive compounds should be available for extraction and utilization. Lemon pomace dried powder was placed under a UV lamp and treated with dosages of 4, 19, 80 and 185 kJ·m(-2), while untreated powder was used as a control...
August 23, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231122/phenolic-profiles-and-antioxidant-activity-of-germinated-legumes
#16
Do Tan Khang, Tran Nhan Dung, Abdelnaser Abdelghany Elzaawely, Tran Dang Xuan
Bioactive compounds, which are naturally produced in plants, have been concerned with the food and pharmaceutical industries because of the pharmacological effects on humans. In this study, the individual phenolics of six legumes during germination and antioxidant capacity from sprout extracts were determined. It was found that the phenolic content significantly increased during germination in all legumes. Peanuts showed the strongest antioxidant capacity in both the DPPH• (1,1-diphenyl-2-picrylhydrazyl) method and the reducing power assay (32...
April 9, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28231088/health-promoting-compounds-in-pigmented-thai-and-wild-rice
#17
Valentina Melini, Rita Acquistucci
Organic pigmented Thai rice and wild rice are commonly available in specialized Italian markets and food shops, and they are gaining popularity among consumers demanding healthy foods. Indeed, the typical colour of kernels, which is the unique characteristic of pigmented cereals, is due to the accumulation of pigments that are also responsible for a number of healthy effects. The aim of this study was to provide a portrait of two organic pigmented Thai rice varieties from Thailand and one wild rice variety from Canada, imported into Italy and at Italian consumers' disposal...
January 20, 2017: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28230263/recent-advances-in-%C3%AE-aminobutyric-acid-gaba-properties-in-pulses-an-overview
#18
REVIEW
Nooshin Nikmaram, B N Dar, Shahin Roohinejad, Mohamed Koubaa, Francisco J Barba, Greiner Ralf, Stuart K Johnson
Beans, peas, and lentils are all types of pulses that are extensively used as foods around the world due to their beneficial effects on human health including their low glycemic index, cholesterol lowering effects, ability to decrease the risk of heart diseases and their protective effects against some cancers. These health benefits are a result of their components such as bioactive proteins, dietary fibers, slowly digested starches, minerals and vitamins, and bioactive compounds. Among these bioactive compounds, γ-aminobutyric acid (GABA), a non-proteinogenic amino acid with numerous reported health benefits (e...
February 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28229941/dual-high-resolution-inhibition-profiling-and-hplc-hrms-spe-nmr-analysis-for-identification-of-%C3%AE-glucosidase-and-radical-scavenging-inhibitors-in-solanum-americanum-mill
#19
Eder L Silva, Rita C Almeida-Lafetá, Ricardo M Borges, Dan Staerk
Solanum americanum is one of the most prominent species used to treat type 2 diabetes in Guatemala. In our ongoing efforts to find antidiabetic and antioxidative compounds from natural sources, an ethyl acetate extract of this medicinal herb was investigated using dual high-resolution α-glucosidase/radical scavenging inhibition profiling. The high-resolution biochromatograms obtained by this technique were used to target subsequent structural elucidation by HPLC-HRMS-SPE-NMR analysis towards the bioactive constituents...
February 13, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28229117/dna-methylation-data-for-identification-of-epigenetic-targets-of-resveratrol-in-triple-negative-breast-cancer-cells
#20
Rubiceli Medina-Aguilar, Carlos Pérez-Plasencia, Patricio Gariglio, Laurence A Marchat, Ali Flores-Pérez, César López-Camarillo, Jaime García Mena
Previous studies revealed that some bioactive food components have anti-cancer effects. However epigenetic effects of dietary compound resveratrol are largely unknown in breast cancer cells (M.A. Dawson, T. Kouzarides, 2012) [1]. Here we provide novel data and comparisons of DNA methylation status of promoter gene regions in response to resveratrol treatment at 24 h and 48 h versus untreated MDA-MB-231 breast cancer cells. DNA methylation changes were measured using Array-PRIMES method (aPRIMES) followed by whole-genome hybridization using human DNA methylation promoter microarray NimbleGen HG18 Refseq Promoter 3×720 K array...
April 2017: Data in Brief
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