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https://www.readbyqxmd.com/read/27904816/an-unusual-presentation-of-nocardiosis-in-an-allogeneic-transplant-recipient
#1
Uroosa Ibrahim, Amina Saqib, Farhan Mohammad, Terenig Terjanian
Nocardiosis is a rare cause of opportunistic infection post hematopoietic stem cell transplant (HSCT) occurring in about 0.3% of patients. The risk factors include delayed immune reconstitution, prolonged neutropenia, and graft-versus-host disease. The most common site of infection is the lung, followed by the brain and the skin. Concomitant pulmonary and central nervous system (CNS) nocardiosis is an extremely rare entity as presented in our case. We present the case of a 72-year-old male at 137 days post transplant presenting with complaints of headache and slurred speech...
October 17, 2016: Curēus
https://www.readbyqxmd.com/read/27891014/chronic-granulomatous-disease-may-be-an-underlying-cause-for-invasive-nocardiosis
#2
Sujoy Khan, Parthasarathi Bhattacharya
No abstract text is available yet for this article.
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27882160/disseminated-nocardiosis-caused-by-nocardia-otitidiscaviarum-in-an-immunocompetent-host-a-case-report-and-literature-review
#3
Yanwen Jiang, Aiben Huang, Qiuhong Fang
The aim of the present study was to summarize the clinical characteristics of nocardiosis caused by Nocardia otitidiscaviarum in order to improve the knowledge of nocardiosis. A case of dissemination nocardiosis caused by N. otitidiscaviarum in an immunocompetent host is reported and the associated literature reviewed. Informed consent for publication of this case report was provided by the patient. The present patient was a young immunocompetent man suffering from disseminated nocardiosis induced by infection with N...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27872648/a-58-year-old-female-with-progressive-cough-and-right-shoulder-pain
#4
Sanket R Thakore, Faisal A Khasawneh
Cavitary pneumonia in immunocompromised patients is a challenging entity. Establishing accurate diagnosis and starting effective antibiotics are essential steps towards improving outcome. A 58-year-old stem cell transplant patient was admitted to the hospital with necrotizing pneumonia caused by nocardia. The disease progressed despite of aggrieve antimicrobial therapy. Nocardiosis continues to be a difficult disease to diagnose and treat.
2016: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/27861348/central-nervous-system-nocardiosis-in-queensland-a-report-of-20-cases-and-review-of-the-literature
#5
Nastaran Rafiei, Anna Maria Peri, Elda Righi, Patrick Harris, David L Paterson
Nocardia infection of the central nervous system (CNS) is an uncommon but clinically important disease, often occurring in immunocompromised individuals and carrying a high mortality rate. We present 20 cases of microbiologically proven CNS nocardiosis diagnosed in Queensland from 1997 to 2015 and review the literature from 1997 to 2016.Over 50% of cases occurred in immunocompromised individuals, with corticosteroid use posing a particularly significant risk factor. Nine (45%) patients were immunocompetent and 3 had no comorbidities at time of diagnosis...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27849440/use-of-cidofovir-for-cytomegalovirus-disease-refractory-to-ganciclovir-in-solid-organ-recipients
#6
Hugo Bonatti, Costi D Sifri, Clara Larcher, Stefan Schneeberger, Camille Kotton, Christian Geltner
BACKGROUND: Solid organ transplantation (SOT) frequently is complicated by cytomegalovirus (CMV) infections. Cidofovir (CDV) is active against CMV, including many ganciclovir (GCV)-resistant mutants, but often is considered to be too nephrotoxic for use after organ transplantation. PATIENTS AND METHODS: Seven males and two females (median age 50.1 years), including two kidney/pancreas, four lung, one small bowel, and two hand recipients, received CDV for refractory CMV disease...
November 16, 2016: Surgical Infections
https://www.readbyqxmd.com/read/27826114/nocardia-elegans-infection-a-case-report-and-literature-review
#7
REVIEW
Itaru Nakamura, Tomoki Nagakura, Hiroaki Fujita, Shinji Fukusima, Tohru Gonoi
A case of disseminated nocardiosis caused by Nocardia elegans in a 72-year-old man with rheumatoid arthritis, treated with tacrolimus and prednisolone, is reported herein. The patient had impaired vision and was diagnosed with endophthalmitis and an abdominal skin abscess. He was started on trimethoprim-sulfamethoxazole treatment, followed by cefepime. The patient was then switched to a combination of imipenem-cilastatin and minocycline. Although the patient survived as a result of surgery and prolonged antibiotic treatment, he eventually lost vision after the infection became resistant to antibiotic treatment...
November 5, 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27747160/nocardia-arthritidis-as-a-cause-of-disseminated-nocardiosis-in-a-patient-with-chronic-lymphocytic-leukemia
#8
Amity L Roberts, Rebecca M Davidson, Alison G Freifeld, Peter C Iwen
A case of disseminated nocardiosis caused by Nocardia arthritidis in an immunocompromised patient with a history of chronic lymphocytic leukemia and rheumatoid arthritis is presented. This report highlights the use for multilocus sequence typing (MLST) in addition to single gene molecular sequencing to identify rare Nocardia species.
2016: IDCases
https://www.readbyqxmd.com/read/27698688/specific-clinical-manifestations-of-nocardia-a-case-report-and-literature-review
#9
Songsong Yu, Jing Wang, Qiuhong Fang, Jixin Zhang, Fengcai Yan
Nocardiosis is a rare bacterial infection of either the lungs (pulmonary) or body (systemic) that usually affects immunocompromised individuals. It is caused by Gram-positive, aerobic actinomycetes of the Nocardia genus. Multiple high-density sheet shadows in both lungs along with nodules or cavities are the most common presentations of nocardiosis, whereas a large pulmonary mass is considered to be rare. However, there is no specificity in the clinical manifestation of the disease. Therefore, isolation and identification of Nocardia strains is the only reliable diagnostic method...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27696601/disseminated-nocardiosis-after-unrelated-bone-marrow-transplantation
#10
Yutaro Hino, Noriko Doki, Yasushi Senoo, Noritaka Sekiya, Shuhei Kurosawa, Satoshi Tsuboi, Kazuteru Ohashi
Nocardiosis is a rare bacterial infection occurring mainly in patients with deficient cell-mediated immunity. Although disseminated nocardiosis after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a rare complication, it is associated with high mortality. Moreover, after allo-HSCT, nocardiosis may be mistaken for other bacterial or fungal infections because clinical and radiographic findings of pulmonary, cerebral, and cutaneous nocardiosis lesions are non-specific. Here, we report a case of disseminated nocardiosis (caused by Nocardia abscessus) with skin, pulmonary, liver, lymph node, and multiple brain abscesses in a patient after allo-HSCT...
October 1, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27659745/-nocardiosis-a-retrospective-case-series-of-19%C3%A2-patients
#11
E M Le Coustumier, E Denes, C Martin, P Weinbreck
INTRODUCTION: Nocardiosis are uncommon. The diagnosis may be difficult, with significant morbidity and mortality, often occurring on frail patients. Few data are available in France. METHODS: A retrospective single center study was conducted from 2002 to 2014 and included all patients with at least one positive microbiological sample for Nocardia with a follow-up in our hospital. RESULTS: Nineteen patients, including 15 men, were included with a mean age of 58 years (25-85)...
September 19, 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/27617207/disseminated-nocardia-farcinica-in-an-immunocompetent-patient
#12
H Boamah, P Puranam, R M Sandre
Nocardia farcinica is a gram-positive, partially acid-fast, methenamine silver-positive aerobic actinomycete that is infrequently associated with nocardiosis. The relative frequency of Nocardia farcinica isolates in nocardiosis is unknown but thought to be under diagnosis. It is increasingly been recognized in immunocompetent patients. We report a case of disseminated Nocardia farcinica causing brain abscess in 55 year old immunocompetent man who was successfully treated with long term antibiotics. The present report illustrates that early detection and treatment of disseminated Nocardia farcinica can lead to a good outcome...
2016: IDCases
https://www.readbyqxmd.com/read/27615155/clinical-characteristics-of-pulmonary-nocardiosis-in-immunocompetent-patients
#13
Tetsuo Fujita, Jun Ikari, Akira Watanabe, Koichiro Tatsumi
Pulmonary nocardiosis is a rare but potentially serious infection typically in immunosuppressed patients (ISPs). It is also known to occur in immunocompetent patients (ICPs). However, little is currently known regarding the clinical characteristics and radiographic findings of pulmonary nocardiosis specifically in ICPs. In this study, 30 patients with pulmonary nocardiosis were identified and 10 were considered to be colonized. Of all patients with pulmonary nocardiosis, 12 patients were ICPs and 18 were ISPs...
September 5, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27613736/comparison-of-restriction-enzyme-pattern-analysis-and-full-gene-sequencing-of-16s-rrna-gene-for-nocardia-species-identification-the-first-report-of-nocardia-transvalensis-isolated-of-sputum-from-iran-and-review-of-the-literature
#14
Mehdi Fatahi-Bafghi, Parvin Heidarieh, Masoumeh Rasouli-Nasab, Shadi Habibnia, Abdorazagh Hashemi-Shahraki, Seyyed Saeed Eshraghi
Nocardial infections occur in different organs of the body and are common in immune disorder diseases of individuals. The aim of this study was to assess Nocardia species identification by phenotypic tests and molecular techniques applied to nocardiosis in Iranian patients. In the current study, various clinical samples were collected and cultured on conventional media and using the paraffin baiting method. Various phenotypic tests were performed. For accurate identification at the species level, restriction fragment length polymorphisms (RFLP) in the hsp65 and partial 16S rRNA genes and full gene sequencing of the 16S rRNA gene were used...
October 2016: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/27578940/disseminated-nocardiosis-masquerading-as-metastatic-malignancy
#15
Rajalakshmi Arjun, Arjun Padmanabhan, Bhanu Prakash Reddy Attunuru, Prerna Gupta
Nocardiosis is an uncommon gram-positive bacterial infection caused by aerobic actinomycetes of the genus Nocardia. It can be localized or systemic and is regarded as an opportunistic infection that is commonly seen in immunocompromised hosts. We report a case of disseminated nocardiosis caused by Nocardia cyriacigeorgica in a patient with underlying malignancy in whom the clinical presentation was highly suggestive of a metastatic disease.
July 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27578932/clinical-spectrum-and-outcome-of-pulmonary-nocardiosis-5-year-experience
#16
Akashdeep Singh, Deepinder Chhina, R K Soni, Chandan Kakkar, U S Sidhu
BACKGROUND: Pulmonary nocardiosis is a rare but a life-threatening infection caused by Nocardia spp. The diagnosis is often missed and delayed resulting in delay in appropriate treatment and thus higher mortality. AIM: In this study, we aim to evaluate the clinical spectrum and outcome of patients with pulmonary nocardiosis. METHODS: A retrospective, 5-year (2009-2014) review of demographic profile, risk factors, clinical manifestations, imaging findings, treatment, and outcome of patients with pulmonary nocardiosis admitted to a tertiary care hospital...
July 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27529219/de-novo-transcriptome-analysis-of-differential-functional-gene-expression-in-largemouth-bass-micropterus-salmoides-after-challenge-with-nocardia-seriolae
#17
Omkar Byadgi, Chi-Wen Chen, Pei-Chyi Wang, Ming-An Tsai, Shih-Chu Chen
Largemouth bass (Micropterus salmoides) are common hosts of an epizootic bacterial infection by Nocardia seriolae. We conducted transcriptome profiling of M. salmoides to understand the host immune response to N. seriolae infection, using the Illumina sequencing platform. De novo assembly of paired-end reads yielded 47,881 unigenes, the total length, average length, N50, and GC content of which were 49,734,288, 1038, 1983 bp, and 45.94%, respectively. Annotation was performed by comparison against non-redundant protein sequence (NR), non-redundant nucleotide (NT), Swiss-Prot, Clusters of Orthologous Groups (COG), Kyoto Encyclopaedia of Genes and Genomes (KEGG), Gene Ontology (GO), and Interpro databases, yielding 28,964 (NR: 60...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27496269/cutaneous-nocardiosis-a-conspicuous-eyelid-eschar
#18
Eden Pappo Lake, Rosemara Hughart, Scott T Jones, Andrew Kreppel, Maria Tsoukas, Amanda T Harrington
No abstract text is available yet for this article.
October 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27488496/pulmonary-melanoma-and-crazy-paving-patterns-in-chest-images-a-case-report-and-literature-review
#19
Yikuan Feng, Jianping Zhao, Qun Yang, Weining Xiong, Guohua Zhen, Yongjian Xu, Zhenxiang Zhang, Huilan Zhang
BACKGROUND: In the lung, melanoma is mostly arranged as patterns of multiple nodules, solitary nodules, or miliary invasions. Very rarely, it also displays a "crazy paving" pattern (also described as a "paving stone," "flagstone," or "slabstone" pattern), which is rarer still in discrete bilateral nodules. This pattern is considered to be caused by pulmonary alveolar proteinosis, but its association with various diseases is unclear. CASE PRESENTATION: A 60-year-old man was diagnosed with pulmonary melanoma...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27445562/pulmonary-nocardiosis-review-of-cases-and-an-update
#20
Malini Shariff, Jayanthi Gunasekaran
Nocardia, a branching, filamentous bacteria, is widely distributed in the environment and can cause human infection in immune-compromised hosts. Inhalation of Nocardia leads to pulmonary disease. Microbiology laboratory processed the clinical samples from patients with respiratory infections. Smears were prepared from the samples and were stained and cultured. Five cases were positive for Nocardia. They were treated with the trimethoprim-sulfamethoxazole combination. The disease was cured in three patients, and two died due to other comorbid conditions leading to complications...
2016: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
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