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https://www.readbyqxmd.com/read/28626172/pulmonary-nocardiosis-a-clinical-analysis-of-30-cases
#1
Yasuo Takiguchi, Shunsuke Ishizaki, Takayuki Kobayashi, Shun Sato, Yaeko Hashimoto, Yosuke Suruga, Yoko Akiba
Objective Pulmonary nocardiosis frequently develops as an opportunistic infection in patients with malignant tumor and is treated with steroids. This study was performed to clarify the clinical features of pulmonary nocardiosis in Japan. Methods The patients definitively diagnosed with pulmonary nocardiosis at our hospital between January 1995 and December 2015 were retrospectively investigated. Results Nineteen men and 11 women (30 in total) were diagnosed with pulmonary nocardiosis. Almost all patients were complicated by a non-pulmonary underlying disease, such as malignant tumor or collagen vascular disease, or pulmonary disease, such as chronic obstructive pulmonary disease or interstitial pneumonia, and 13 patients (43...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28614268/pulmonary-and-cutaneous-infection-caused-by-nocardia-farcinica-in-a-patient-with-nephrotic-syndrome-a-case-report
#2
Ning Zhu, Yuan Zhu, Yi Wang, Shaoshao Dong
RATIONALE: Nocardia species is known as conditional pathogenic bacteria. Disseminated infection caused by Nocardia species is rare and occurs primarily in immunosuppressed patients. Signs and symptoms of this infection are frequently nonspecific making early diagnosis and treatment difficult. PATIENT CONCERNS: We report a case of subcutaneous and pulmonary nocardiosis due to Nocardia farcinica (N farcinica) in a patient with nephrotic syndrome who is undergoing long-term corticosteroid therapy...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28606302/-brain-abscesses-caused-by-nocardia-farcinica-in-a-kidney-transplanted-man
#3
Michaela Tinggaard, Kristian Bagge
Nocardiosis is primarily an opportunistic infection caused by aerobic Gram-positive bacteria of the genus Nocardia. In this case report we describe a male patient who previously received a kidney transplant and was admitted to hospital with chills, headache and pain in the neck and left eye, tremor and coordination problems. A magnetic resonance scan of the brain showed multiple abscesses, and blood culture was positive for Nocardia farcinica. Nocardiosis of the central nervous system is a rare, but serious differential diagnosis in immunosuppressed patients with signs of high intracranial pressure...
June 5, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28602739/adjuvant-effect-of-recombinant-interleukin-12-in-the-nocardiosis-formalin-killed-vaccine-of-the-amberjack-seriola-dumerili
#4
Megumi Matsumoto, Kyosuke Araki, Kazuma Hayashi, Yutaka Takeuchi, Kazuhiro Shiozaki, Hiroaki Suetake, Atsushi Yamamoto
Nocardiosis causes serious economic damage in the fish farming of Japanese yellowtail fish. Nocardia seriolae identified as pathogenic bacterium is an intracellular-pathogen. In general, induction of cell-mediated immunity (CMI) is effective in infection defense against intracellular-pathogen. However, the conventional formalin-killed N. seriolae (FKC) vaccine induces humoral immunity. Interleukin-12 (IL-12) is Th1 type heterodimeric cytokine and induces cell differentiation in mammals. Our previous study showed that recombinant amberjack IL-12 has a role in CMI induction in vitro and could be a possible CMI inducing adjuvant...
June 7, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28602386/respiratory-infections-associated-with-anti-tnf%C3%AE-agents
#5
REVIEW
E Blanchard, M-E Truchetet, I Machelart, J Séneschal, C Raherison-Semjen
Anti-TNFα agents have proved effective in the treatment of various inflammatory, rheumatologic, dermatologic, and gastrointestinal diseases. Severe respiratory tract infections of bacterial or fungal origin have emerged as important complications in patients receiving such treatments. The risk of infection due to anti-TNFα therapy is difficult to assess in these patients who are immunocompromised because of the underlying disease itself and of previous or concomitant immunosuppressive drugs. This excessive infection risk seems real, particularly in the first six months following treatment initiation, and higher for patients receiving anti-TNFα monoclonal antibodies than for those receiving soluble TNFα receptor...
June 8, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28595598/isolation-biochemical-and-molecular-identification-of-nocardia-species-among-tb-suspects-in-northeastern-tanzania-a-forgotten-or-neglected-threat
#6
Abubakar S Hoza, Sayoki G S Mfinanga, Irmgard Moser, Brigitte König
BACKGROUND: Pulmonary nocardiosis mimic pulmonary tuberculosis in most clinical and radiological manifestations. In Tanzania, where tuberculosis is one of the major public health threat clinical impact of nocardiosis as the cause of the human disease remains unknown. The objective of the present study was to isolate and identify Nocardia isolates recovered from TB suspects in Northeastern, Tanzania by using biochemical and molecular methods. METHODS: The study involved 744 sputum samples collected from 372 TB suspects from four periphery diagnostic centers in Northeastern, Tanzania...
June 8, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28573992/nocardia-infection-following-intraocular-surgery-report-of-seven-cases-from-a-tertiary-eye-hospital
#7
Devesh Sharma, Umang Mathur, Abha Gour, Manisha Acharya, Nidhi Gupta, Neelam Sapra
PURPOSE: To study the outcome of ocular nocardiosis following intraocular surgery. MATERIALS AND METHODS: A retrospective review of medical records of all postoperative cases of culture proven Nocardia infection over a period of 3 years, from October 2010 to September 2013, was performed. Microbiological analysis was performed for all cases and included smears and cultures. Fortified 2% amikacin eye drops were the mainstay of treatment. Surgical intervention was performed in case of nonresponse to medical therapy or suspected endophthalmitis...
May 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28573414/primary-cutaneous-nocardiosis-a-pitfall-in-the-diagnosis-of-skin-infection
#8
Mercè Grau Pérez, Antonio Casabella Pernas, María Del Pilar de la Rosa Del Rey, Rosa Torrado González
No abstract text is available yet for this article.
June 1, 2017: Infection
https://www.readbyqxmd.com/read/28566662/practical-management-of-deep-cutaneous-fungal-infections
#9
Tomotaka Sato
Understanding deep cutaneous fungal infection requires not only reading many case reports and checking the typical clinical images of skin lesions, but also managing the patients properly to prevent misdiagnosis. Herein, I review my recent experiences with eight typical cases of deep cutaneous infections (including protothecosis and nocardiosis) in Japan. It is very important to do the four management processes; namely, KOH direct microscopic examination, skin biopsy, fungal culture, and microscopic examination of the histopathological specimen of PAS and Grocott staining...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28559710/cutaneous-nocardiosis-manifesting-as-a-frontal-mass-in-a-patient-with-giant-cell-arteritis
#10
Violeta Tincuta Briciu, Mirela Flonta, Mihaela Lupse, Laura Damian
We report the case of a subcutaneous abscess due to Nocardia spp. mimicking a spontaneous hematoma or an aneurysm of the temporal artery branch, in a giant cell arteritis patient treated with methylprednisolone and azathioprine. Ultrasonography, incision and drainage with cultures helped in the diagnosis. This case highlights the importance of considering rare pathogens in immunosuppressed patients, besides the more frequent disease complications.
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/28507832/disseminated-nocardia-farcinica-pneumonia-with-left-adrenal-gland-abscess
#11
Christopher Jackson, Brennan McCullar, Kiran Joglekar, Ankur Seth, Hiren Pokharna
Adrenal masses pose a diagnostic challenge. The differential diagnosis includes functional adrenal tumors, incidentally found adrenal masses, metastases from an unknown primary cancer, and abscesses. Infrequently, adrenal gland abscesses have been reported in disseminated nocardiosis affecting immunocompetent and immunocompromised patients. We report a case of disseminated Nocardia farcinica pneumonia with an adrenal gland abscess in an immunocompetent patient with no identified risk factors for nocardiosis...
April 12, 2017: Curēus
https://www.readbyqxmd.com/read/28500674/disseminated-cutaneous-nocardiosis-with-ocular-involvement
#12
Aya Nishizawa, Miki Hirose, Yuiko Nagata, Masaru Takeuchi, Takahiro Satoh
A 45-year-old Japanese woman presented with a five-day history of multiple papular eruptions and a fever >38°C. For the past 10 years, she had been treated with oral prednisolone (10 mg/day) and cyclosporine (100 mg/day) to treat mixed connective tissue disease and autoimmune hepatitis. On physical examination, multiple papules and pustules were observed on her face, trunk, and extremities. Some lesions had dermal or subcutaneous nodules. This article is protected by copyright. All rights reserved.
May 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28491889/infections-in-hematopoietic-cell-transplant-recipients-results-from-the-organ-transplant-infection-project-a-multicenter-prospective-cohort-study
#13
Mindy G Schuster, Angela A Cleveland, Erik R Dubberke, Carol A Kauffman, Robin K Avery, Shahid Husain, David L Paterson, Fernanda P Silveira, Tom M Chiller, Kaitlin Benedict, Kathleen Murphy, Peter G Pappas
BACKGROUND: Infection is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). Our object was to better define the epidemiology and outcomes of infections after HCT. METHODS: This was a prospective, multicenter cohort study of HCT recipients and conducted from 2006 to 2011. The study included 4 US transplant centers and 444 HCT recipients. Data were prospectively collected for up to 30 months after HCT using a standardized data collection tool...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28407752/detection-of-high-serum-levels-of-%C3%AE-d-glucan-in-disseminated-nocardial-infection-a-case-report
#14
Toyomitsu Sawai, Takumi Nakao, Shota Yamaguchi, Sumako Yoshioka, Nobuko Matsuo, Naofumi Suyama, Katsunori Yanagihara, Hiroshi Mukae
BACKGROUND: β-D-glucan (BDG) is a helpful diagnostic marker for many invasive fungal infections, but not for nocardiosis. Here, we reported the first case of nocardial infection with high serum level of BDG. CASE PRESENTATION: A 73-year-old man was hospitalized because of fever, headache, and appetite loss after 10 months of steroid and immunosuppressive therapy for cryptogenic organizing pneumonia. With a diagnosis of bacterial pneumonia, treatment with ampicillin/sulbactam was initiated...
April 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28397286/primary-cutaneous-nocardiosis-caused-by-nocardia-brasiliensis-following-a-wasp-sting
#15
L Chu, X Xu, Y Ran
We report a case of an 87-year-old woman who presented with painful erythema of her right forearm 10 days after she had been stung by a wasp on her right hand. The lesion had rapidly deteriorated during the week before presentation, and treatment with antibiotics and glucocorticoids did not improve the condition. After careful evaluation, we performed cultures from the lesion aspiration, and morphological and genetic analysis of bacteria cultures confirmed a bacterial infection with Nocardia brasiliensis. The patient recovered after 3 weeks...
April 10, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28372487/nocardiosis-in-freshwater-reared-chinook-salmon-oncorhynchus-tshawytscha
#16
C L Brosnahan, S Humphrey, G Knowles, H J Ha, A Pande, J B Jones
CASE HISTORY: An investigation was conducted to identify the cause of mortalities in freshwater reared Chinook salmon (Oncorhynchus tshawytscha). Mortalities occurred in juvenile salmon, at a salmon rearing facility in the South Island of New Zealand. The affected fish were from a pen inside the facility with no surrounding pens or other year classes affected. CLINICAL FINDINGS: Clinically affected fish presented with skin lesions. The majority of skin lesions were unruptured, boil-like, raised circular masses up to 4 cm in diameter, particularly on the dorsolateral aspects and the flank...
April 26, 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/28352469/successful-treatment-of-pulmonary-nocardiosis-with-fluoroquinolone-in-bronchial-asthma-and-bronchiectasis
#17
Hironori Sadamatsu, Koichiro Takahashi, Hiroki Tashiro, Kazutoshi Komiya, Tomomi Nakamura, Naoko Sueoka-Aragane
A 72-year-old Japanese woman was admitted at Saga University Hospital for fever, malaise, and productive cough. Six years ago, she had been diagnosed with bronchial asthma and was treated with inhaled corticosteroids. Chest radiograph and computed tomography on admission showed infiltrates in the right middle lobe, a mass lesion in the left lower lobe, and bronchiectasis in both lower lobes. Sputum examination showed Gram-positive rods with phagocytosis by neutrophils. These bacilli were identified as Nocardia otitidiscaviarum by 16S ribosomal RNA sequencing...
May 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28348912/nocardia-brasiliensis-infection-complicating-cryptogenic-organizing-pneumonia
#18
Alison M Fernandes, Jason C Sluzevich, Isabel Mira-Avendano
Pulmonary nocardiosis is a severe and uncommon opportunistic infection caused by Nocardia species. We present a patient with cryptogenic organizing pneumonia who was receiving long-term immunosuppressive therapy, whose treatment course was complicated by cutaneous and pulmonary nocardiosis. Tissue cultures confirmed Nocardia brasiliensis. Nocardiosis should be a diagnostic consideration for patients treated with long-term immunosuppression who have worsening pulmonary symptoms and relapsing pustular skin lesions...
2017: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/28348776/first-case-report-of-pulmonary-nocardiosis-caused-by-nocardia-mexicana
#19
Tomokazu Kuchibiro, Takeshi Ikeda, Hirotaka Nakanishi, Yukiko Morishita, Katsuyuki Houdai, Junko Ito, Tohru Gonoi
INTRODUCTION: Nocardia species usually cause opportunistic infections, and the frequency of these infections is increasing owing to the growing population of immunocompromised hosts. However, Nocardia species may sometimes cause an infection disease in immunocompetent hosts. Nocardia mexicana infections are the least common and are very rare. CASE PRESENTATION: Herein, we report the first case of a pulmonary infection with N. mexicana in a 61-year-old Japanese woman with a history of hyperlipidaemia and bronchiectasis and a 6-month history of non-productive hacking cough...
August 2016: JMM Case Reports
https://www.readbyqxmd.com/read/28329348/outcome-and-treatment-of-nocardiosis-after-solid-organ-transplantation-new-insights-from-a-european-study
#20
David Lebeaux, Romain Freund, Christian van Delden, Hélène Guillot, Sierk D Marbus, Marie Matignon, Eric Van Wijngaerden, Benoit Douvry, Julien De Greef, Fanny Vuotto, Leïla Tricot, Mario Fernández-Ruiz, Jacques Dantal, Cédric Hirzel, Jean-Philippe Jais, Veronica Rodriguez-Nava, Frédérique Jacobs, Olivier Lortholary, Julien Coussement
Background: Solid organ transplant (SOT) recipients are at risk of nocardiosis, a rare opportunistic bacterial infection, but prognosis and outcome of these patients are poorly defined. Our objectives were to identify factors associated with 1-year mortality after nocardiosis and describe the outcome of patients receiving short-course antibiotics (≤120 days). Methods: We analyzed data from a multicenter European case-control study that included 117 SOT recipients with nocardiosis diagnosed between 2000 and 2014...
May 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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