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Nocardiosis

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https://www.readbyqxmd.com/read/28407752/detection-of-high-serum-levels-of-%C3%AE-d-glucan-in-disseminated-nocardial-infection-a-case-report
#1
Toyomitsu Sawai, Takumi Nakao, Shota Yamaguchi, Sumako Yoshioka, Nobuko Matsuo, Naofumi Suyama, Katsunori Yanagihara, Hiroshi Mukae
BACKGROUND: β-D-glucan (BDG) is a helpful diagnostic marker for many invasive fungal infections, but not for nocardiosis. Here, we reported the first case of nocardial infection with high serum level of BDG. CASE PRESENTATION: A 73-year-old man was hospitalized because of fever, headache, and appetite loss after 10 months of steroid and immunosuppressive therapy for cryptogenic organizing pneumonia. With a diagnosis of bacterial pneumonia, treatment with ampicillin/sulbactam was initiated...
April 13, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28397286/primary-cutaneous-nocardiosis-caused-by-nocardia-brasiliensis-following-a-wasp-sting
#2
L Chu, X Xu, Y Ran
We report a case of an 87-year-old woman who presented with painful erythema of her right forearm 10 days after she had been stung by a wasp on her right hand. The lesion had rapidly deteriorated during the week before presentation, and treatment with antibiotics and glucocorticoids did not improve the condition. After careful evaluation, we performed cultures from the lesion aspiration, and morphological and genetic analysis of bacteria cultures confirmed a bacterial infection with Nocardia brasiliensis. The patient recovered after 3 weeks...
April 10, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28372487/nocardiosis-in-freshwater-reared-chinook-salmon-oncorhynchus-tshawytscha
#3
C L Brosnahan, S Humphrey, G Knowles, H J Ha, A Pande, J B Jones
CASE HISTORY: An investigation was conducted to identify the cause of mortalities in freshwater reared Chinook salmon (Oncorhynchus tshawytscha). Mortalities occurred in juvenile salmon, at a salmon rearing facility in the South Island of New Zealand. The affected fish were from a pen inside the facility with no surrounding pens or other year classes affected. CLINICAL FINDINGS: Clinically affected fish presented with skin lesions. The majority of skin lesions were unruptured, boil-like, raised circular masses up to 4 cm in diameter, particularly on the dorsolateral aspects and the flank...
April 3, 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/28352469/successful-treatment-of-pulmonary-nocardiosis-with-fluoroquinolone-in-bronchial-asthma-and-bronchiectasis
#4
Hironori Sadamatsu, Koichiro Takahashi, Hiroki Tashiro, Kazutoshi Komiya, Tomomi Nakamura, Naoko Sueoka-Aragane
A 72-year-old Japanese woman was admitted at Saga University Hospital for fever, malaise, and productive cough. Six years ago, she had been diagnosed with bronchial asthma and was treated with inhaled corticosteroids. Chest radiograph and computed tomography on admission showed infiltrates in the right middle lobe, a mass lesion in the left lower lobe, and bronchiectasis in both lower lobes. Sputum examination showed Gram-positive rods with phagocytosis by neutrophils. These bacilli were identified as Nocardia otitidiscaviarum by 16S ribosomal RNA sequencing...
May 2017: Respirology Case Reports
https://www.readbyqxmd.com/read/28348912/nocardia-brasiliensis-infection-complicating-cryptogenic-organizing-pneumonia
#5
Alison M Fernandes, Jason C Sluzevich, Isabel Mira-Avendano
Pulmonary nocardiosis is a severe and uncommon opportunistic infection caused by Nocardia species. We present a patient with cryptogenic organizing pneumonia who was receiving long-term immunosuppressive therapy, whose treatment course was complicated by cutaneous and pulmonary nocardiosis. Tissue cultures confirmed Nocardia brasiliensis. Nocardiosis should be a diagnostic consideration for patients treated with long-term immunosuppression who have worsening pulmonary symptoms and relapsing pustular skin lesions...
2017: Case Reports in Pulmonology
https://www.readbyqxmd.com/read/28348776/first-case-report-of-pulmonary-nocardiosis-caused-by-nocardia-mexicana
#6
Tomokazu Kuchibiro, Takeshi Ikeda, Hirotaka Nakanishi, Yukiko Morishita, Katsuyuki Houdai, Junko Ito, Tohru Gonoi
INTRODUCTION: Nocardia species usually cause opportunistic infections, and the frequency of these infections is increasing owing to the growing population of immunocompromised hosts. However, Nocardia species may sometimes cause an infection disease in immunocompetent hosts. Nocardia mexicana infections are the least common and are very rare. CASE PRESENTATION: Herein, we report the first case of a pulmonary infection with N. mexicana in a 61-year-old Japanese woman with a history of hyperlipidaemia and bronchiectasis and a 6-month history of non-productive hacking cough...
August 2016: JMM Case Reports
https://www.readbyqxmd.com/read/28329348/outcome-and-treatment-of-nocardiosis-after-solid-organ-transplantation-new-insights-from-a-european-study
#7
David Lebeaux, Romain Freund, Christian van Delden, Hélène Guillot, Sierk D Marbus, Marie Matignon, Eric Van Wijngaerden, Benoit Douvry, Julien De Greef, Fanny Vuotto, Leïla Tricot, Mario Fernández-Ruiz, Jacques Dantal, Cédric Hirzel, Jean-Philippe Jais, Veronica Rodriguez-Nava, Frédérique Jacobs, Olivier Lortholary, Julien Coussement
Background: Solid organ transplant (SOT) recipients are at risk of nocardiosis, a rare opportunistic bacterial infection, but prognosis and outcome of these patients are poorly defined. Our objectives were to identify factors associated with one-year mortality after nocardiosis and describe the outcome of patients receiving short-course antibiotics (≤120 days). Methods: We analyzed data from a multicenter European case-control study that included 117 SOT recipients with nocardiosis diagnosed between 2000 and 2014...
February 4, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28299015/endogenous-nocardial-endophthalmitis-in-an-immunosuppressed-patient-a-serious-warning-of-an-underlying-life-threatening-and-blinding-disorder
#8
Hemant Trehan, Jaya Kaushik, Vaibhav Kumar Jain, Jitendra Kumar Singh Parihar, Abhijit Avasthi
PURPOSE: To report a case of bilateral endogenous nocardial endophthalmitis with central nervous system involvement in an immunocompromised individual with an extremely poor outcome. CASE REPORT: A 35-year-old man with a history of long-term, prescribed oral steroid use for membranoproliferative glomerulonephritis presented with profound bilateral vision loss. Patient's diagnosis of bilateral endogenous nocardial endophthalmitis was delayed. Nocardia was finally isolated from a brain biopsy after a repeat magnetic resonance imaging revealed a brain abscess...
January 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28292374/pleural-nocardiosis-in-immunocompetent-patient
#9
Mohsin Zahoor, Ali Abbas, Zafar Ahmed
No abstract text is available yet for this article.
January 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28257489/analysis-of-the-complete-genome-sequence-of-nocardia-seriolae-utf1-the-causative-agent-of-fish-nocardiosis-the-first-reference-genome-sequence-of-the-fish-pathogenic-nocardia-species
#10
Motoshige Yasuike, Issei Nishiki, Yuki Iwasaki, Yoji Nakamura, Atushi Fujiwara, Yoshiko Shimahara, Takashi Kamaishi, Terutoyo Yoshida, Satoshi Nagai, Takanori Kobayashi, Masaya Katoh
Nocardiosis caused by Nocardia seriolae is one of the major threats in the aquaculture of Seriola species (yellowtail; S. quinqueradiata, amberjack; S. dumerili and kingfish; S. lalandi) in Japan. Here, we report the complete nucleotide genome sequence of N. seriolae UTF1, isolated from a cultured yellowtail. The genome is a circular chromosome of 8,121,733 bp with a G+C content of 68.1% that encodes 7,697 predicted proteins. In the N. seriolae UTF1 predicted genes, we found orthologs of virulence factors of pathogenic mycobacteria and human clinical Nocardia isolates involved in host cell invasion, modulation of phagocyte function and survival inside the macrophages...
2017: PloS One
https://www.readbyqxmd.com/read/28252662/susceptibility-profiles-of-nocardia-spp-to-antimicrobial-and-antituberculotic-agents-detected-by-a-microplate-alamar-blue-assay
#11
Pan Zhao, Xiujuan Zhang, Pengcheng Du, Guilian Li, Luxi Li, Zhenjun Li
Nocardia species are ubiquitous in natural environments and can cause nocardiosis. Trimethoprim-sulfamethoxazole has long been the monotherapy treatment of choice, but resistance to this treatment has recently emerged. In this study, we used microplate Alamar Blue assays to determine the antimicrobial susceptibility patterns of 65 standard Nocardia isolates, including 28 type strains and 20 clinical Nocardia isolates, to 32 antimicrobial agents, including 13 little studied drugs. Susceptibility to the most commonly used drug, trimethoprim-sulfamethoxazole, was observed in 98% of the isolates...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28202876/primary-cutaneous-nocardiosis-in-an-immunocompetent-patient
#12
Rentaro Oda, Yoshiyuki Sekikawa, Igen Hongo
No abstract text is available yet for this article.
2017: Internal Medicine
https://www.readbyqxmd.com/read/28176520/-pulmonary-co-infection-due-to-nocardia-cyriacigeorgica-and-aspergillus-fumigatus
#13
R Trastoy, T Manso, X García, G Barbeito, D Navarro, P Rascado, M L Pérez Del Molino
OBJECTIVE: Pulmonary nocardiosis is an uncommon pulmonary infection caused by aerobic gram-positive bacteria of the genus Nocardia. Nocardia sp. are environmental organisms spread worldwide. Approximately 50 Nocardia species have been described to date, about 30 of which are known to cause human disease. Nocardia cyriacigeorgica was first reported in 2001. CASE REPORT: We report a case of infection caused by N. cyriacigeorgica in a patient with B-cells non-Hodgkin lymphoma and diabetes mellitus...
February 8, 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28166920/tuberculosis-the-great-imitator-a-usual-disease-with-unusual-presentations
#14
Sujata Jetley, Zeeba S Jairajpuri, Mukta Pujani, Sabina Khan, Safia Rana
BACKGROUND: A number of infectious diseases have been referred to by the phrase 'The Great Imitator', of which the oldest is syphilis; others include Lyme disease, nocardiosis, etc. Tuberculosis has been described as the second great imitator as it can imitate various other disease processes. An awareness of the atypical clinical manifestations of tuberculosis is important, especially in regions where tuberculosis continues to be a major public health problem, such as India. Extrapulmonary tuberculosis (EPTB) constitutes about 15-20% of all cases of tuberculosis in immunocompetent patients and accounts for more than 50% of the cases in human immunodeficiency virus (HIV)-positive individuals...
January 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28159010/disseminated-nocardiosis-in-renal-transplant-recipient-under-therapy-for-pulmonary-tuberculosis-a-case-report
#15
Priyatam Khadka, Ramesh Bahadur Basnet, Pratap Khadka, Dibya Singh Shah, Bharat Mani Pokhrel, Basista Parsad Rijal, Jeevan Bahadur Sherchand
BACKGROUND: Nocardiosis is an opportunistic infection in a patient with underlying immune suppression and organ transplant. Clinical syndromes are varied and ranges from pulmonary, disseminated, cutaneous along with central nervous system involvement. CASE PRESENTATION: Herein, we report a rare case of disseminated pulmonary nocardiosis with cerebral manifestation in a 66 year-old-Nepali farmer; with a history of renal transplantation and undergoing therapy for pulmonary tuberculosis...
February 3, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28150374/nocardia-liver-abscess-post-liver-transplantation-a-rare-presentation
#16
Pavan Hanchanale, Mayank Jain, Joy Varghese, Jayanthi V, Mohamed Rela
Nocardiosis is usually a disseminated disease seen in immunocompromised individuals. We herein present a rare case of isolated Nocardia liver abscess post liver transplantation. The patient responded well to treatment and is on long-term antibiotics for Nocardia infection.
February 1, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28149666/a-case-of-central-nervous-system-nocardiosis-in-a-patient-with-lupus-treated-with-belimumab
#17
Richard Hc Lai, Deborah Kim, Florina Constantinescu
Belimumab was approved by the United States Food and Drug Administration in March 2011 as the first biological agent for treating active systemic lupus erythematosus (SLE). To the best of our knowledge, this is the first case report regarding a patient with SLE treated with belimumab who was diagnosed with central nervous system nocardiosis.
December 2016: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28112090/pulmonary-nocardiosis-caused-by-nocardia-otitidiscaviarum-in-an-adult-asthmatic-female-patient-the-presence-of-acid-fast-branching-filaments-is-always-significant
#18
A Mahgoub, S A Gumaa, M R P Joseph, M S Saleh, A H A Elsheikh, A I Elkhalifa, E Elhaj, R R M Salih, M E Hamid
We report a case of pulmonary nocardiosis in a 41-year-old asthma patient. Chest radiographs showed bilateral air space and consolidations.Acid-fast branching filaments were demonstrated in sputum, and the grown organism was identified phenotypically and confirmed using16S rDNA sequencing (accession no. KX500116). The patient received a combination of medical treatments, but developed complications,which were managed over the next 3 months, after which she was discharged. Pulmonary nocardiosis should be considered in patientsundergoing steroid therapy or when a chronic infection does not respond to first-line treatment...
December 21, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/28109291/systemic-nocardiosis-in-a-dog-caused-by-nocardia-cyriacigeorgica
#19
Yesari Eroksuz, Nafia Canan Gursoy, Tolga Karapinar, Burak Karabulut, Canan Akdeniz Incili, Zeynep Yerlikaya, Zulal Asci Toraman, Mehmet Ozkan Timurkan, Hatice Eroksuz
BACKGROUND: Systemic nocardiosis due to Nocardia cyriacigeorgica has not been reported in dogs. CASE PRESENTATION: Light and electron microscopy, microbiological culture and molecular identification (PCR) were used to diagnose systemic nocardiosis caused by Nocardia cyriacigeorgica in a 3-month-old husky dog. The postmortem changes included multifocal to coalescing, sharply circumscribed pyogranulomatous inflammation and abscess formation in lungs, liver, myocardium, spleen, kidneys, brain, and hilar lymph nodes...
January 21, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28105096/nocardiosis-in-ectopic-acth-syndrome-a-case-report-and-review-of-11-cases-from-the-literature
#20
Lichen Xu, Qiaomai Xu, Meifang Yang, Hainv Gao, Mingzhi Xu, Weihang Ma
Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) associated with nocardiosis is rare, and little information is available regarding its clinical characteristics. In this study, the case of a 35-year-old male patient who showed significant cushingoid features and had a cough with yellow phlegm for 1 month is described. Pulmonary computed tomography (CT) scanning and (18)F-fluorodeoxyglucose positron emission tomography combined with CT identified two different lesions in the mediastinum and pulmonary region, respectively...
December 2016: Experimental and Therapeutic Medicine
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