Pradeep Rajasekhar, Simona E Carbone, Stuart T Johnston, Cameron J Nowell, Lukasz Wiklendt, Edmund J Crampin, Yinghan She, Jesse J DiCello, Ayame Saito, Luke Sorensen, Thanh Nguyen, Kevin Mc Lee, John A Hamilton, Sebastian K King, Emily M Eriksson, Nick J Spencer, Brian D Gulbransen, Nicholas A Veldhuis, Daniel P Poole
BACKGROUND: Mechanosensation is an important trigger of physiological processes in the gastrointestinal tract. Aberrant responses to mechanical input are associated with digestive disorders, including visceral hypersensitivity. Transient Receptor Potential Vanilloid 4 (TRPV4) is a mechanosensory ion channel with proposed roles in visceral afferent signaling, intestinal inflammation, and gut motility. While TRPV4 is a potential therapeutic target for digestive disease, current mechanistic understanding of how TRPV4 may influence gut function is limited by inconsistent reports of TRPV4 expression and distribution...
January 11, 2024: bioRxiv