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https://www.readbyqxmd.com/read/29031381/-adolescent-vulnerabilities-and-radicalisation
#1
Adrien Lenjalley, Rahmeth Radjack, Maude Ludot, Fatima Touhami, Marie Rose Moro
Radicalisation resonates with the psychological vulnerabilities of adolescents. The ups and downs encountered as they attempt to construct their identity and their need to dominate favour the destructive nature of young people lacking a sense of filiation and belonging. An adolescent's engagement corresponds to a search for limits, with an adherence to religious values and to a group to establish self-esteem. Subjectification, authorising the adolescent to separate themselves from their parents and their values through a period of crisis must be supported...
October 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/29029551/low-back-pain-investigation-of-biases-in-outpatient-canadian-physical-therapy
#2
Maude Laliberté, Barbara Mazer, Tatiana Orozco, Gevorg Chilingaryan, Bryn Williams-Jones, Matthew Hunt, Debbie Ehrmann Feldman
Background: Previous research suggested that physical therapy services can be influenced by patient characteristics (age, sex, socioeconomic status) or insurance status rather than their clinical need. Objective: The aim of this study was to determine whether patient-related factors (age, sex, SES) and the source of reimbursement for physical therapy services (insurance status) influence wait time for, frequency of, and duration of physical therapy for low back pain...
October 1, 2017: Physical Therapy
https://www.readbyqxmd.com/read/29026178/erratum-one-month-spaceflight-compromises-the-bone-microstructure-tissue-level-mechanical-properties-osteocyte-survival-and-lacunae-volume-in-mature-mice-skeletons
#3
Maude Gerbaix, Vasily Gnyubkin, Delphine Farlay, Cécile Olivier, Patrick Ammann, Guillaume Courbon, Norbert Laroche, Rachel Genthial, Hélène Follet, Françoise Peyrin, Boris Shenkman, Guillemette Gauquelin-Koch, Laurence Vico
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025809/cycle-of-life
#4
Maude MacInnis
No abstract text is available yet for this article.
October 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29025761/genome-wide-association-study-to-find-modifiers-for-tetralogy-of-fallot-in-the-22q11-2-deletion-syndrome-identifies-variants-in-the-gpr98-locus-on-5q14-3
#5
Tingwei Guo, Gabriela M Repetto, Donna M McDonald McGinn, Jonathan H Chung, Hiroko Nomaru, Christopher L Campbell, Anna Blonska, Anne S Bassett, Eva W C Chow, Elisabeth E Mlynarski, Ann Swillen, Joris Vermeesch, Koen Devriendt, Doron Gothelf, Miri Carmel, Elena Michaelovsky, Maude Schneider, Stephan Eliez, Stylianos E Antonarakis, Karlene Coleman, Aoy Tomita-Mitchell, Michael E Mitchell, M Cristina Digilio, Bruno Dallapiccola, Bruno Marino, Nicole Philip, Tiffany Busa, Leila Kushan-Wells, Carrie E Bearden, Małgorzata Piotrowicz, Wanda Hawuła, Amy E Roberts, Flora Tassone, Tony J Simon, Esther D A van Duin, Thérèse A van Amelsvoort, Wendy R Kates, Elaine Zackai, H Richard Johnston, David J Cutler, A J Agopian, Elizabeth Goldmuntz, Laura E Mitchell, Tao Wang, Beverly S Emanuel, Bernice E Morrow
BACKGROUND: The 22q11.2 deletion syndrome (22q11.2DS; DiGeorge syndrome/velocardiofacial syndrome) occurs in 1 of 4000 live births, and 60% to 70% of affected individuals have congenital heart disease, ranging from mild to severe. In our cohort of 1472 subjects with 22q11.2DS, a total of 62% (n=906) have congenital heart disease and 36% (n=326) of these have tetralogy of Fallot (TOF), comprising the largest subset of severe congenital heart disease in the cohort. METHODS AND RESULTS: To identify common genetic variants associated with TOF in individuals with 22q11...
October 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/29024938/expression-and-role-of-tyro3-and-axl-as-potential-therapeutical-targets-in-leiomyosarcoma
#6
Carmela Dantas-Barbosa, Tom Lesluyes, François Le Loarer, Fréderic Chibon, Isabelle Treilleux, Jean-Michel Coindre, Pierre Meeus, Mehdi Brahmi, Olivia Bally, Isabelle Ray-Coquard, Marie-Pierre Sunyach, Axel Le Cesne, Olivier Mir, Sylvie Bonvalot, Maud Toulmonde, Antoine Italiano, Pierre Saintigny, Myriam Jean-Denis, Francoise Ducimetiere, Dominique Ranchere, Hiba El Sayadi, Laurent Alberti, Jean-Yves Blay
BACKGROUND: Leiomyosarcoma (LMS) are 15% of adult sarcomas and remain seldom curable in metastatic phase. The TAM receptors and their ligands are overexpressed or activated in multiple malignancies, including LMS. METHODS: The TAM receptor and ligand expression was evaluated in LMS cell lines and 358 sarcoma samples by either gene expression or immunohistochemistry. TYRO3 and AXL were knocked down. Crizotinib and foretinib were investigated in vitro. RESULTS: High expression of TYRO3 and AXL was detected in LMS cell lines...
October 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29024866/diclofenac-but-not-celecoxib-improves-endothelial-function-in-rheumatoid-arthritis-a-study-in-adjuvant-induced-arthritis
#7
Frank Verhoeven, Perle Totoson, Christine Marie, Anne Prigent-Tessier, Daniel Wendling, Maude Tournier-Nappey, Clément Prati, Céline Demougeot
BACKGROUND AND AIMS: We aimed at investigating the effect of celecoxib (COX-2 selective inhibitor) and diclofenac (non-selective COX inhibitor) on endothelial function, and at identifying the underlying mechanisms in adjuvant-induced arthritis (AIA). METHODS: At the first signs of AIA, diclofenac (5 mg/kg twice a day, i.p), celecoxib (3 mg/kg/day, i.p) or saline (Vehicle) was administered for 3 weeks. Endothelial function was studied in aortic rings relaxed with acetylcholine (Ach) with or without inhibitors of NOS, arginase, EDHF and superoxide anions (O2(-°)) production...
September 29, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29021180/bluetongue-virus-spread-in-europe-is-a-consequence-of-climatic-landscape-and-vertebrate-host-factors-as-revealed-by-phylogeographic-inference
#8
Maude Jacquot, Kyriaki Nomikou, Massimo Palmarini, Peter Mertens, Roman Biek
Spatio-temporal patterns of the spread of infectious diseases are commonly driven by environmental and ecological factors. This is particularly true for vector-borne diseases because vector populations can be strongly affected by host distribution as well as by climatic and landscape variables. Here, we aim to identify environmental drivers for bluetongue virus (BTV), the causative agent of a major vector-borne disease of ruminants that has emerged multiple times in Europe in recent decades. In order to determine the importance of climatic, landscape and host-related factors affecting BTV diffusion across Europe, we fitted different phylogeographic models to a dataset of 113 time-stamped and geo-referenced BTV genomes, representing multiple strains and serotypes...
October 11, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29020158/modeling-risk-factor-trajectories-when-measurement-tools-change-sequentially-during-follow-up-in-cohort-studies-application-to-dietary-habits-in-prodromal-dementia
#9
Maude Wagner, Jean-François Dartigues, Cécilia Samieri, Cécile Proust-Lima
Modeling risk factor trajectories is critical to understand the natural history of diseases; yet, the measurement tools used to assess risk factors often evolve during follow-up in cohorts and such change prevents longitudinal analyses using standard models. The authors propose to address this issue with a Latent Process Model. Trajectories of average intakes of five food families (Fish, Meat, Fruits, Vegetables, Carbohydrate-rich foods) were described in prodromal dementia during the 10 years prior to diagnosis of cases and compared to those of controls, using a case-control sample nested within the Three-City Study, Bordeaux, France (1999-2012)...
August 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29020102/dusp3-deletion-in-mice-promotes-experimental-lung-tumour-metastasis-in-a-macrophage-dependent-manner
#10
Maud Vandereyken, Sophie Jacques, Eva Van Overmeire, Mathieu Amand, Natacha Rocks, Céline Delierneux, Pratibha Singh, Maneesh Singh, Camille Ghuysen, Caroline Wathieu, Tinatin Zurashvili, Nor Eddine Sounni, Michel Moutschen, Christine Gilles, Cécile Oury, Didier Cataldo, Jo A Van Ginderachter, Souad Rahmouni
Vaccinia-H1 Related (VHR) dual-specificity phosphatase, or DUSP3, plays an important role in cell cycle regulation and its expression is altered in several human cancers. In mouse model, DUSP3 deletion prevents neo-angiogenesis and b-FGF-induced microvessel outgrowth. Considering the importance of angiogenesis in metastasis formation, our study aimed to investigate the role of DUSP3 in tumour cell dissemination. Using a Lewis Lung carcinoma (LLC) experimental metastasis model, we observed that DUSP3-/- mice developed larger lung metastases than littermate controls...
2017: PloS One
https://www.readbyqxmd.com/read/28994578/tuning-the-gold-nanoparticle-colorimetric-assay-by-nanoparticle-size-concentration-and-size-combinations-for-oligonucleotide-detection
#11
Varsha S Godakhindi, Peiyuan Kang, Maud Serre, Naga Aravind Revuru, Jesse Minghao Zou, Michael Robert Roner, Ruth Levitz, Jeffrey Kahn, Jaona Randrianalisoa, Zhenpeng Qin
Gold nanoparticle (GNP)-based aggregation assay is simple, fast, and employs a colorimetric detection method. Although previous studies have reported using GNP-based colorimetric assay to detect biological and chemical targets, a mechanistic and quantitative understanding of the assay and effects of GNP parameters on the assay performance is lacking. In this work, we investigated this important aspect of the GNP aggregation assay including effects of GNP concentration and size, on the assay performance to detect malarial DNA...
October 10, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28988909/detailed-muscular-structure-and-neural-control-anatomy-of-the-levator-ani-muscle-a-study-based-on-female-human-fetuses
#12
Krystel Nyangoh Timoh, David Moszkowicz, Mazen Zaitouna, Cedric Lebacle, Jelena Martinovic, Djibril Diallo, Maud Creze, Vincent Lavoue, Emile Darai, Gérard Benoit, Thomas Bessede
BACKGROUND: Injury to the levator ani muscle or pelvic nerves during pregnancy and vaginal delivery are responsible for pelvic floor dysfunction. OBJECTIVE: To demonstrate the presence of smooth muscular cell areas within the levator ani muscle and describe their localization and innervation. STUDY DESIGN: Five female human fetuses were studied after approval from the French Biomedicine Agency. Specimens were serially sectioned and stained by Masson's trichrome and immunostained for striated and smooth muscle, as well as for somatic, adrenergic, cholinergic, and nitriergic nerve fibers...
October 5, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28988455/safety-profiles-of-percutaneous-left-atrial-appendage-closure-devices-an-analysis-of-the-food-and-drug-administration-manufacturer-and-user-facility-device-experience-maude-database-from-2009-2016
#13
Mohammad-Ali Jazayeri, Venkat Vuddanda, Mohit K Turagam, Valay Parikh, Madhav Lavu, Donita Atkins, Matthew Earnest, Luigi Di Biase, Andrea Natale, David Wilber, Yeruva Madhu Reddy, Dhanunjaya Lakkireddy
BACKGROUND: Percutaneous left atrial appendage closure (LAAC) is a viable option for AF patients who are unable to tolerate long term oral anticoagulation (OAC). OBJECTIVE: We sought to assess the safety of two commonly used percutaneous devices for LAA closure in the United States by analysis of surveillance data from the FDA Manufacturer and User Facility Device Experience (MAUDE) database. METHODS: The MAUDE database was queried between May 1, 2006 and May 1, 2016 for LARIAT® (SentreHEART Inc...
October 8, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28982971/sound-production-mechanism-in-pomatoschistus-pictus
#14
Eric Parmentier, Maud Petrinisec, Paulo J Fonseca, M Clara P Amorim
Fish acoustic signals play a major role during agonistic and reproductive interactions. Among the sound-generating fish, Gobiidae, a large fish taxa with 1866 valid species, is one of the most studied groups of acoustic fishes with sound production being documented in a number of species. Paradoxically, the sound producing mechanism remains poorly studied in this group. The painted goby Pomatoschistus pictus produces two distinct sounds called drums and thumps. A combination of morphological and experimental analyses involving high-speed videos synchronized with sound recordings supports that drums are produced during lateral head movements involving at least the alternate contractions of the muscles levator pectoralis originating on the skull and inserting on the pectoral girdle...
October 5, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28981728/competition-between-translation-initiation-factor-eif5-and-its-mimic-protein-5mp-determines-non-aug-initiation-rate-genome-wide
#15
Leiming Tang, Jacob Morris, Ji Wan, Chelsea Moore, Yoshihiko Fujita, Sarah Gillaspie, Eric Aube, Jagpreet Nanda, Maud Marques, Maika Jangal, Abbey Anderson, Christian Cox, Hiroyuki Hiraishi, Leiming Dong, Hirohide Saito, Chingakham Ranjit Singh, Michael Witcher, Ivan Topisirovic, Shu-Bing Qian, Katsura Asano
In the human genome, translation initiation from non-AUG codons plays an important role in various gene regulation programs. However, mechanisms regulating the non-AUG initiation rate remain poorly understood. Here, we show that the non-AUG initiation rate is nearly consistent under a fixed nucleotide context in various human and insect cells. Yet, it ranges from <1% to nearly 100% compared to AUG translation, depending on surrounding sequences, including Kozak, and possibly additional nucleotide contexts...
September 18, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28975160/current-knowledge-of-scoliosis-in-physiotherapy-students-trained-in-the-united-kingdom
#16
D A Jason Black, Christine Pilcher, Shawn Drake, Erika Maude, David Glynn
BACKGROUND: It has been highlighted in both Poland and the United States of America (USA) that knowledge of idiopathic scoliosis (IS) among physiotherapy students is limited with respect to the 2011 International Society on Scoliosis Orthopaedic and Rehabilitation Treatment (SOSORT) guidelines. Early detection of scoliosis and correct initial management is essential in effective care, and thus physiotherapists should be aware of the basic criteria for diagnosis and indications for treatment...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28974199/tissue-aware-rna-seq-processing-and-normalization-for-heterogeneous-and-sparse-data
#17
Joseph N Paulson, Cho-Yi Chen, Camila M Lopes-Ramos, Marieke L Kuijjer, John Platig, Abhijeet R Sonawane, Maud Fagny, Kimberly Glass, John Quackenbush
BACKGROUND: Although ultrahigh-throughput RNA-Sequencing has become the dominant technology for genome-wide transcriptional profiling, the vast majority of RNA-Seq studies typically profile only tens of samples, and most analytical pipelines are optimized for these smaller studies. However, projects are generating ever-larger data sets comprising RNA-Seq data from hundreds or thousands of samples, often collected at multiple centers and from diverse tissues. These complex data sets present significant analytical challenges due to batch and tissue effects, but provide the opportunity to revisit the assumptions and methods that we use to preprocess, normalize, and filter RNA-Seq data - critical first steps for any subsequent analysis...
October 3, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28973848/lipidomics-reveals-diurnal-lipid-oscillations-in-human-skeletal-muscle-persisting-in-cellular-myotubes-cultured-in-vitro
#18
Ursula Loizides-Mangold, Laurent Perrin, Bart Vandereycken, James A Betts, Jean-Philippe Walhin, Iain Templeman, Stéphanie Chanon, Benjamin D Weger, Christine Durand, Maud Robert, Jonathan Paz Montoya, Marc Moniatte, Leonidas G Karagounis, Jonathan D Johnston, Frédéric Gachon, Etienne Lefai, Howard Riezman, Charna Dibner
Circadian clocks play an important role in lipid homeostasis, with impact on various metabolic diseases. Due to the central role of skeletal muscle in whole-body metabolism, we aimed at studying muscle lipid profiles in a temporal manner. Moreover, it has not been shown whether lipid oscillations in peripheral tissues are driven by diurnal cycles of rest-activity and food intake or are able to persist in vitro in a cell-autonomous manner. To address this, we investigated lipid profiles over 24 h in human skeletal muscle in vivo and in primary human myotubes cultured in vitro...
September 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28971225/online-coupling-of-immunoextraction-digestion-and-microliquid-chromatography-tandem-mass-spectrometry-for-the-analysis-of-sarin-and-soman-butyrylcholinesterase-adducts-in-human-plasma
#19
Maud Bonichon, Valentina Valbi, Audrey Combès, Charlotte Desoubries, Anne Bossée, Valérie Pichon
Organophosphorus nerve agent (OPNA) adducts formed with human butyrylcholinesterase (HuBuChE) can be used as biomarker of OPNA exposure. Indeed, intoxication by OPNAs can be confirmed by the LC/MS(2) analysis of a specific HuBuChE nonapeptide on which OPNAs covalently bind. A fast, selective, and highly sensitive online method was developed to detect sarin and soman adducts in plasma, including immunoextraction by anti-HuBuChE antibodies, pepsin digestion on immobilized enzyme reactors (IMER), and microLC/MS(2) analysis of the OPNA adducts...
October 2, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28961172/a-cross-sectional-serosurvey-of-anti-orthopoxvirus-antibodies-in-central-and-western-africa
#20
Siv Aina J Leendertz, Daniel Stern, Dennis Theophil, Etile Anoh, Arsène Mossoun, Grit Schubert, Lidewij Wiersma, Chantal Akoua-Koffi, Emmanuel Couacy-Hymann, Jean-Jacques Muyembe-Tamfum, Stomy Karhemere, Maude Pauly, Livia Schrick, Fabian H Leendertz, Andreas Nitsche
Since the eradication of smallpox and the subsequent discontinuation of the worldwide smallpox vaccination program, other Orthopoxviruses beside Variola virus have been increasingly representing a risk to human health. To investigate the extent of natural contact with Orthopoxviruses and possible demographic risk factors for such an exposure, we performed a cross-sectional serosurvey of anti-Orthopoxvirus IgG antibodies in West and Central Africa. To this end, people living in forest regions in Côte d'Ivoire (CIV, n = 737) and the Democratic Republic of the Congo (COD, n = 267) were assigned into groups according to their likely smallpox vaccination status...
September 29, 2017: Viruses
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