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https://www.readbyqxmd.com/read/28324611/automated-analysis-of-intracellular-dynamic-processes
#1
Yao Yao, Ihor Smal, Ilya Grigoriev, Maud Martin, Anna Akhmanova, Erik Meijering
The study of intracellular dynamic processes is of fundamental importance for understanding a wide variety of diseases and developing effective drugs and therapies. Advanced fluorescence microscopy imaging systems nowadays allow the recording of virtually any type of process in space and time with super-resolved detail and with high sensitivity and specificity. The large volume and high information content of the resulting image data, and the desire to obtain objective, quantitative descriptions and biophysical models of the processes of interest, require a high level of automation in data analysis...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28323846/problems-identified-by-dual-sensory-impaired-older-adults-in-long-term-care-when-using-a-self-management-program-a-qualitative-study
#2
Lieve Roets-Merken, Sytse Zuidema, Myrra Vernooij-Dassen, Marianne Dees, Pieter Hermsen, Gertrudis Kempen, Maud Graff
OBJECTIVE: To gain insights into the problems of dual sensory impaired older adults in long-term care. Insights into these problems are essential for developing adequate policies which address the needs of the increasing population of dual sensory impaired older adults in long-term care. METHODS: A qualitative study was conducted in parallel with a cluster randomized controlled trial. Dual sensory impaired older adults in the intervention group (n = 47, age range 82-98) were invited by a familiar nurse to identify the problems they wanted to address...
2017: PloS One
https://www.readbyqxmd.com/read/28323491/the-effect-of-closed-eye-tear-film-conditions-on-blood-isolated-neutrophils-in-vitro
#3
Cameron Postnikoff, Maud Gorbet
PURPOSE: Eyelid closure results in influx of neutrophils onto the ocular surface, which are non-responsive to inflammatory stimuli. This investigation examined whether incubation of blood-isolated neutrophils in closed-eye conditions induce a tear-film neutrophil phenotype. METHODS: Blood-isolated neutrophils were incubated combining various conditions: hypoxia, corneal epithelial cells (HCEC), artificial tear solution (ATS). RESULTS: A hypoxic environment induced no differential effect on membrane receptor expression...
March 21, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28319314/progesterone-to-prevent-preterm-birth-the-studies-are-getting-better-but-there-is-still-room-for-improvement
#4
Carr Men Chung, Maud van Zijl, Jeffrey A Keelan, Ben Willem Mol
Spontaneous preterm birth (PTB) remains one of the pressing problems of modern obstetrics. Allen and Corner first isolated progesterone and proposed the name because of its pro-gestational activity (Allen 1930). Progesterone prolongs pregnancy via a range of actions in the myometrium, cervix and placenta which, when exploited pharmacologically, might delay or even prevent PTB. This article is protected by copyright. All rights reserved.
March 20, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28318945/identification-and-structure-activity-relationships-of-quinoline-tertiary-alcohol-modulators-of-ror%C3%AE-t
#5
David A Kummer, Maxwell D Cummings, Marta Abad, Joseph Barbay, Glenda Castro, Ronald Wolin, Kevin D Kreutter, Umar Maharoof, Cynthia Milligan, Rachel Nishimura, Joan Pierce, Celine Schalk-Hihi, John Spurlino, Maud Urbanski, Hariharan Venkatesan, Aihua Wang, Craig Woods, Xiaohua Xue, James P Edwards, Anne M Fourie, Kristi Leonard
A high-throughput screen of the ligand binding domain of the nuclear receptor retinoic acid-related orphan receptor gamma t (RORγt) employing a thermal shift assay yielded a quinoline tertiary alcohol hit. Optimization of the 2-, 3- and 4-positions of the quinoline core using structure-activity relationships and structure-based drug design methods led to the discovery of a series of modulators with improved RORγt inhibitory potency and inverse agonism properties.
February 21, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28318622/computer-assisted-topological-analysis-of-renal-allograft-inflammation-adds-to-risk-evaluation-at-diagnosis-of-humoral-rejection
#6
Antoine Sicard, Vannary Meas-Yedid, Maud Rabeyrin, Alice Koenig, Stephanie Ducreux, Frederique Dijoud, Valerie Hervieu, Lionel Badet, Emmanuel Morelon, Jean Christophe Olivo-Marin, Valerie Dubois, Olivier Thaunat
Antibody-mediated rejection is associated with heterogeneous kidney allograft outcomes. Accurate evaluation of risk for graft loss at time of diagnosis is necessary to offer personalized treatment. In contrast with serological and molecular assessment, morpho-histological evaluation of antibody-mediated rejection lesions has not significantly evolved. This relies on Banff classifications designed to be of diagnostic discriminatory power rather than prognostic and face quantitative and qualitative limitations...
March 15, 2017: Kidney International
https://www.readbyqxmd.com/read/28314856/ubc9-is-required-for-positive-selection-and-late-stage-maturation-of-thymocytes
#7
Aibo Wang, Xiao Ding, Maud Demarque, Xindong Liu, Deng Pan, Huawei Xin, Bo Zhong, Xiaohu Wang, Anne Dejean, Wei Jin, Chen Dong
SUMOylation is an important posttranslational modification that regulates protein function in diverse biological processes. However, its role in early T cell development has not been genetically studied. UBC9 is the only E2 enzyme for all SUMOylation. In this study, by selectively deleting Ubc9 gene in T cells, we have investigated the functional roles of SUMOylation in T cell development. Loss of Ubc9 results in a significant reduction of CD4 and CD8 single-positive lymphocytes in both thymus and periphery...
March 17, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28301472/independent-introductions-and-admixtures-have-contributed-to-adaptation-of-european-maize-and-its-american-counterparts
#8
Jean-Tristan Brandenburg, Tristan Mary-Huard, Guillem Rigaill, Sarah J Hearne, Hélène Corti, Johann Joets, Clémentine Vitte, Alain Charcosset, Stéphane D Nicolas, Maud I Tenaillon
Through the local selection of landraces, humans have guided the adaptation of crops to a vast range of climatic and ecological conditions. This is particularly true of maize, which was domesticated in a restricted area of Mexico but now displays one of the broadest cultivated ranges worldwide. Here, we sequenced 67 genomes with an average sequencing depth of 18x to document routes of introduction, admixture and selective history of European maize and its American counterparts. To avoid the confounding effects of recent breeding, we targeted germplasm (lines) directly derived from landraces...
March 16, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28298599/bushmeat-hunting-and-zoonotic-transmission-of-simian-t-lymphotropic-virus-1-in-tropical-west-and-central-africa
#9
Arsène Mossoun, Sébastien Calvignac-Spencer, Augustin E Anoh, Maude S Pauly, Daniel A Driscoll, Adam O Michel, Lavry Grah Nazaire, Stefan Pfister, Pascale Sabwe, Ulla Thiesen, Barbara R Vogler, Lidewij Wiersma, Jean-Jacques Muyembe-Tamfum, Stomy Karhemere, Chantal Akoua-Koffi, Emmanuel Couacy-Hymann, Barbara Fruth, Roman M Wittig, Fabian H Leendertz, Grit Schubert
Simian T-lymphotropic virus 1 (STLV-1) enters human populations through contact with non-human primate (NHP) bushmeat. We tested whether differences in the extent of contact to STLV-1 infected NHP bushmeat foster regional differences in prevalence of human HTLV-1. Using serological and PCR assays, we screened humans and NHP at two sub-Saharan African sites where subsistence hunting was expected to be less (Taï region, Côte d'Ivoire, CIV) or more developed (Bandundu region, Democratic Republic of the Congo, DRC)...
March 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28296957/computer-assisted-electromagnetic-navigation-improves-accuracy-in-computed-tomography-guided-interventions-a-prospective-randomized-clinical-trial
#10
Pierre Durand, Alexandre Moreau-Gaudry, Anne-Sophie Silvent, Julien Frandon, Emilie Chipon, Maud Médici, Ivan Bricault
PURPOSE: To assess the accuracy and usability of an electromagnetic navigation system designed to assist Computed Tomography (CT) guided interventions. MATERIALS AND METHODS: 120 patients requiring a percutaneous CT intervention (drainage, biopsy, tumor ablation, infiltration, sympathicolysis) were included in this prospective randomized trial. Nineteen radiologists participated. Conventional procedures (CT group) were compared with procedures assisted by a navigation system prototype using an electromagnetic localizer to track the position and orientation of a needle holder (NAV group)...
2017: PloS One
https://www.readbyqxmd.com/read/28296884/increased-von-willebrand-factor-decreased-adamts13-and-thrombocytopenia-in-melioidosis
#11
Emma Birnie, Gavin C K W Koh, Ester C Löwenberg, Joost C M Meijers, Rapeephan R Maude, Nicholas P J Day, Sharon J Peacock, Tom van der Poll, W Joost Wiersinga
BACKGROUND: Melioidosis, caused by bioterror treat agent Burkholderia pseudomallei, is an important cause of community-acquired Gram-negative sepsis in Southeast Asia and Northern Australia. New insights into the pathogenesis of melioidosis may help improve treatment and decrease mortality rates from this dreadful disease. We hypothesized that changes in Von Willebrand factor (VWF) function should occur in melioidosis, based on the presence of endothelial stimulation by endotoxin, pro-inflammatory cytokines and thrombin in melioidosis, and investigated whether this impacted on outcome...
March 15, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28296529/computed-tomography-and-clinical-outcome-in-patients-with-severe-traumatic-brain-injury
#12
Maud Stenberg, Lars-Owe D Koskinen, Per Jonasson, Richard Levi, Britt-Marie Stålnacke
OBJECTIVE: To study: (i) acute computed tomography (CT) characteristics and clinical outcome; (ii) clinical course and (iii) Corticosteroid Randomisation after Significant Head Injury acute calculator protocol (CRASH) model and clinical outcome in patients with severe traumatic brain injury (sTBI). METHODS: Initial CT (CTi) and CT 24 hours post-trauma (CT24) were evaluated according to Marshall and Rotterdam classifications. Rancho Los Amigos Cognitive Scale-Revised (RLAS-R) and Glasgow Outcome Scale Extended (GOSE) were assessed at three months and one year post-trauma...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28287264/prospective-evaluation-of-free-energy-calculations-for-the-prioritization-of-cathepsin-l-inhibitors
#13
Bernd Kuhn, Michal Tichý, Lingle Wang, Shaughnessy Robinson, Rainer E Martin, Andreas Kuglstatter, Jörg Benz, Maude Giroud, Tanja Schirmeister, Robert Abel, François Diederich, Jérôme Hert
Improving the binding affinity of a chemical series by systematically probing one of its exit vectors is a medicinal chemistry activity that can benefit from molecular modeling input. Herein, we compare the effectiveness of four approaches in prioritizing building blocks with better potency: selection by a medicinal chemist, manual modeling, docking followed by manual filtering, and free energy calculations (FEP). Our study focused on identifying novel substituents for the apolar S2 pocket of cathepsin L and was conducted entirely in a prospective manner with synthesis and activity determination of 36 novel compounds...
March 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28267118/development-of-a-survey-to-explore-factors-influencing-the-adoption-of-best-practices-for-diabetic-foot-ulcer-offloading
#14
Maude Bleau Lavigne, Isabelle Reeves, Marie-Josée Sasseville, Christine Loignon
PURPOSE: The primary purpose of this study was to develop 2 survey tools to explore factors influencing adoption of best practices for diabetic foot ulcer offloading treatment in primary health care settings. One survey was intended for the patients receiving care for a diabetic foot ulcer in primary health care settings and the other was intended for the health professionals providing treatment. The second purpose of this study was to evaluate the psychometric properties of the 2 surveys...
March 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28264750/bilateral-nail-gun-traumatic-brain-injury-presents-as-intentional-overdose-a-case-report
#15
Judith Alain, Pascal Lavergne, Maude St-Onge, Myreille D'Astous, Stéphane Côté
This report describes a rare but life-threatening case of a suicide attempt initially considered as intentional overdose at the emergency department. Persistent altered mental status, despite normal toxicology investigations, led the attending team to order a head computed tomography scan, which revealed a bilateral penetrating nail gun injury with a right temporal hematoma for which a decompressive craniectomy was performed. Although voluntary intoxication is the most frequent form of suicide attempt, emergency physicians must be alert and maintain a broad differential diagnosis...
March 7, 2017: CJEM
https://www.readbyqxmd.com/read/28264341/new-hexactinellid-sponges-from-deep-mediterranean-canyons
#16
Nicole Boury-Esnault, Jean Vacelet, Maude Dubois, Adrien Goujard, Maïa Fourt, Thierry Pérez, Pierre Chevaldonné
During the exploration of the NW Mediterranean deep-sea canyons (MedSeaCan and CorSeaCan cruises), several hexactinellid sponges were observed and collected by ROV and manned submersible. Two of them appeared to be new species of Farrea and Tretodictyum. The genus Farrea had so far been reported with doubt from the Mediterranean and was listed as "taxa inquirenda" for two undescribed species. We here provide a proper description for the specimens encountered and sampled. The genus Tretodictyum had been recorded several times in the Mediterranean and in the near Atlantic as T...
February 21, 2017: Zootaxa
https://www.readbyqxmd.com/read/28263896/prevalence-of-the-mcr-1-colistin-resistance-gene-in-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli-from-human-faecal-samples-collected-in-2012-in-rural-villages-in-shandong-province-china
#17
Zhenwang Bi, Björn Berglund, Qiang Sun, Maud Nilsson, Baoli Chen, Maria Tärnberg, Lilu Ding, Cecilia Stålsby Lundborg, Zhenqiang Bi, Göran Tomson, Jingjing Yao, Zhanying Gu, Xiao Yin, Zengqiang Kou, Lennart E Nilsson
Since its initial discovery in China in 2015, the plasmid-mediated colistin resistance gene mcr-1 has been reported in Escherichia coli isolated from clinical samples, animals and meat worldwide. In this study, 706 extended-spectrum β-lactamase (ESBL)-producing E. coli from 411 persons were detected in a collection of faecal samples from 1000 rural residents in three counties in Shandong Province, China. These isolates were screened for mcr-1 and phenotypic colistin resistance. The gene was found in 3.5% of the isolates (from 4...
March 2, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28263134/standing-cough-test-for-evaluation-of-post-prostatectomy-incontinence-a-pilot-study
#18
Allen F Morey, Nirmish Singla, Maude Carmel, Alexandra Klein, Timothy J Tausch, Jordan Siegel, Isamu Tachibana, Jeremy Scott
INTRODUCTION: We implemented a standardized Standing Cough Test (SCT) for assessment of men with post-prostatectomy incontinence (PPI) and stratified results according to an objective clinical grading scale in an attempt to facilitate male anti-incontinence surgical procedure selection. MATERIALS AND METHODS: SCT was routinely performed during the initial outpatient consultation for PPI. Incontinence severity was recorded based on a novel Male Stress Incontinence Grading Scale (MSIGS) to stratify PPI...
February 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28261011/multiquadric-spline-based-interactive-segmentation-of-vascular-networks
#19
Sachin Meena, V B Surya Prasath, Yasmin M Kassim, Richard J Maude, Olga V Glinskii, Vladislav V Glinsky, Virginia H Huxley, Kannappan Palaniappan
Commonly used drawing tools for interactive image segmentation and labeling include active contours or boundaries, scribbles, rectangles and other shapes. Thin vessel shapes in images of vascular networks are difficult to segment using automatic or interactive methods. This paper introduces the novel use of a sparse set of user-defined seed points (supervised labels) for precisely, quickly and robustly segmenting complex biomedical images. A multiquadric spline-based binary classifier is proposed as a unique approach for interactive segmentation using as features color values and the location of seed points...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28261007/random-forests-for-dura-mater-microvasculature-segmentation-using-epifluorescence-images
#20
Yasmin M Kassim, V B Surya Prasath, Rengarajan Pelapur, Olga V Glinskii, Richard J Maude, Vladislav V Glinsky, Virginia H Huxley, Kannappan Palaniappan
Automatic segmentation of microvascular structures is a critical step in quantitatively characterizing vessel remodeling and other physiological changes in the dura mater or other tissues. We developed a supervised random forest (RF) classifier for segmenting thin vessel structures using multiscale features based on Hessian, oriented second derivatives, Laplacian of Gaussian and line features. The latter multiscale line detector feature helps in detecting and connecting faint vessel structures that would otherwise be missed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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