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https://www.readbyqxmd.com/read/29211310/presentation-and-outcome-of-frequent-and-rare-sarcoma-histologic-subtypes-a-study-of-10-262-patients-with-localized-visceral-soft-tissue-sarcoma-managed-in-reference-centers
#1
Nicolas Penel, Jean-Michel Coindre, Antoine Giraud, Philippe Terrier, Dominique Ranchere-Vince, Françoise Collin, Sophie L E Guellec, Céline Bazille, Marick Lae, Gonzague de Pinieux, Isabelle L Ray-Coquard, Sylvie Bonvalot, Axel L E Cesne, Yves-Marie Robin, Eberhardt Stoeckle, Maud Toulmonde, Jean-Yves Blay
BACKGROUND: The objective of this study was to describe characteristics at diagnosis and outcomes of adults with soft tissue sarcoma. METHODS: The authors conducted a retrospective multicenter study of 12,262 patients who were treated between January 1980 and 31 December 2013 in French Sarcoma Group centers and enrolled in the "Conticabase." Diagnoses were systematically reviewed by expert pathologists, and entities were classified according to the 2013 World Health Organization classification...
December 6, 2017: Cancer
https://www.readbyqxmd.com/read/29208939/diet-breadth-modulates-preference-performance-relationships-in-a-phytophagous-insect-community
#2
Maud Charlery de la Masselière, Benoît Facon, Abir Hafsi, Pierre-François Duyck
In most phytophagous insects, larvae are less mobile than adults and their fitness depends on the plant chosen by their mother. To maximize fitness, adult preference and larval performance should thus be correlated. This correlation is not always apparent and seems to increase with the level of specialisation, i.e. specialists have a stronger preference for high quality host plant species compared to generalists. The aim of this study was to test whether the relationship between female preference and larval performance was stronger for specialists than for generalists within a community of fruit flies (Diptera: Tephritidae)...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29206287/high-dose-per-pulse-electron-beam-dosimetry-commissioning-of-the-oriatron-ert6-prototype-linear-accelerator-for-preclinical-use
#3
Maud Jaccard, Maria Teresa Durán, Kristoffer Petersson, Jean-François Germond, Philippe Liger, Marie-Catherine Vozenin, Jean Bourhis, François Bochud, Claude Bailat
PURPOSE: The Oriatron eRT6 is an experimental high dose-per-pulse linear accelerator (linac) which was designed to deliver an electron beam with variable dose-rates, ranging from a few Gy/min up to hundreds of Gy/s. It was built to study the radiobiological effects of high dose-per-pulse/dose-rate electron beam irradiation, in the context of preclinical and cognitive studies. In this work, we report on the commissioning and beam monitoring of the Oriatron eRT6 prototype linac. MATERIALS AND METHODS: The beam was characterized in different steps...
December 5, 2017: Medical Physics
https://www.readbyqxmd.com/read/29202467/endothelial-chimerism-and-vascular-sequestration-protect-pancreatic-islet-grafts-from-antibody-mediated-rejection
#4
Chien-Chia Chen, Eric Pouliquen, Alexis Broisat, Francesco Andreata, Maud Racapé, Patrick Bruneval, Laurence Kessler, Mitra Ahmadi, Sandrine Bacot, Carole Saison-Delaplace, Marina Marcaud, Jean-Paul Duong Van Huyen, Alexandre Loupy, Jean Villard, Sandrine Demuylder-Mischler, Thierry Berney, Emmanuel Morelon, Meng-Kun Tsai, Marie-Nathalie Kolopp-Sarda, Alice Koenig, Virginie Mathias, Stéphanie Ducreux, Catherine Ghezzi, Valerie Dubois, Antonino Nicoletti, Thierry Defrance, Olivier Thaunat
Humoral rejection is the most common cause of solid organ transplant failure. Here, we evaluated a cohort of 49 patients who were successfully grafted with allogenic islets and determined that the appearance of donor-specific anti-HLA antibodies (DSAs) did not accelerate the rate of islet graft attrition, suggesting resistance to humoral rejection. Murine DSAs bound to allogeneic targets expressed by islet cells and induced their destruction in vitro; however, passive transfer of the same DSAs did not affect islet graft survival in murine models...
November 20, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29202107/a-multi-level-spatial-analysis-of-clinical-malaria-and-subclinical-plasmodium-infections-in-pailin-province-cambodia
#5
Daniel M Parker, Rupam Tripura, Thomas J Peto, Richard J Maude, Chea Nguon, Jeremy Chalk, Pasathorn Sirithiranont, Mallika Imwong, Lorenz von Seidlein, Nicholas J White, Arjen M Dondorp
Background: The malaria burden is decreasing throughout the Greater Mekong Subregion, however transmission persists in some areas. Human movement, subclinical infections and complicated transmission patterns contribute to the persistence of malaria. This research describes the micro-geographical epidemiology of both clinical malaria and subclinical Plasmodium infections in three villages in Western Cambodia. Methods: Three villages in Western Cambodia were selected for the study based on high reported Plasmodium falciparum incidence...
November 2017: Heliyon
https://www.readbyqxmd.com/read/29199269/dendrogenin-a-drives-lxr-to-trigger-lethal-autophagy-in-cancers
#6
Gregory Segala, Marion David, Philippe de Medina, Mathias C Poirot, Nizar Serhan, François Vergez, Aurelie Mougel, Estelle Saland, Kevin Carayon, Julie Leignadier, Nicolas Caron, Maud Voisin, Julia Cherier, Laetitia Ligat, Frederic Lopez, Emmanuel Noguer, Arnaud Rives, Bruno Payré, Talal Al Saati, Antonin Lamaziere, Gaëtan Despres, Jean-Marc Lobaccaro, Silvere Baron, Cecile Demur, Fabienne de Toni, Clément Larrue, Helena Boutzen, Fabienne Thomas, Jean-Emmanuel Sarry, Marie Tosolini, Didier Picard, Michel Record, Christian Récher, Marc Poirot, Sandrine Silvente-Poirot
Dendrogenin A (DDA) is a newly discovered cholesterol metabolite with tumor suppressor properties. Here, we explored its efficacy and mechanism of cell death in melanoma and acute myeloid leukemia (AML). We found that DDA induced lethal autophagy in vitro and in vivo, including primary AML patient samples, independently of melanoma Braf status or AML molecular and cytogenetic classifications. DDA is a partial agonist on liver-X-receptor (LXR) increasing Nur77, Nor1, and LC3 expression leading to autolysosome formation...
December 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/29198749/mitochondrial-fission-is-associated-with-ucp1-activity-in-human-brite-beige-adipocytes
#7
Didier F Pisani, Valentin Barquissau, Jean-Claude Chambard, Diane Beuzelin, Rayane A Ghandour, Maude Giroud, Aline Mairal, Sophie Pagnotta, Saverio Cinti, Dominique Langin, Ez-Zoubir Amri
OBJECTIVE: Thermogenic adipocytes (i.e. brown or brite/beige adipocytes) are able to burn large amounts of lipids and carbohydrates as a result of highly active mitochondria and enhanced uncoupled respiration, due to UCP1 activity. Although mitochondria are the key organelles for this thermogenic function, limited human data are available. METHODS/RESULTS: We characterized changes in the mitochondrial function of human brite adipocytes, using hMADS cells as a model of white- to brite-adipocyte conversion...
November 22, 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/29196382/relatedness-of-antibodies-to-peptides-containing-homocitrulline-or-citrulline-in-patients-with-rheumatoid-arthritis
#8
Patrick Lac, Maud Racapé, Lillian Barra, David A Bell, Ewa Cairns
OBJECTIVE: Antibodies that target citrullinated protein/peptide (ACPA) and homocitrullinated/carbamylated protein/peptide (AHCPA) are associated with rheumatoid arthritis (RA). The relationship between ACPA and AHCPA remains unclear. We examined the expression and cross-reactivity of these antibodies using citrulline- and homocitrulline-containing synthetic peptides, CitJED and HomoCitJED, respectively, which have equal numbers of citrulline or homocitrulline residues on the same peptide backbone...
December 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29192915/observation-of-a-raman-mode-splitting-in-few-layer-black-phosphorus-encapsulated-with-hexagonal-boron-nitride
#9
J M Urban, M Baranowski, A Surrente, D Wlodarczyk, A Suchocki, G Long, Y Wang, L Klopotowski, N Wang, D K Maude, P Plochocka
We investigate the impact of encapsulation with hexagonal boron nitride (h-BN) on the Raman spectrum of few layer black phosphorus. The encapsulation results in a significant reduction of the line width of the Raman modes of black phosphorus, due to a reduced phonon scattering rate. We observe a so far elusive peak in the Raman spectra ∼4 cm-1 above the A mode in trilayer and thicker flakes, which had not been observed experimentally. The newly observed mode originates from the strong black phosphorus inter-layer interaction, which induces a hardening of the surface atom vibration with respect to the corresponding modes of the inner layers...
December 1, 2017: Nanoscale
https://www.readbyqxmd.com/read/29190658/screening-tools-to-identify-patients-with-complex-health-needs-at-risk-of-high-use-of-health-care-services-a-scoping-review
#10
Valérie Marcoux, Maud-Christine Chouinard, Fatoumata Diadiou, Isabelle Dufour, Catherine Hudon
BACKGROUND: Many people with chronic conditions have complex health needs often due to multiple chronic conditions, psychiatric comorbidities, psychosocial issues, or a combination of these factors. They are at high risk of frequent use of healthcare services. To offer these patients interventions adapted to their needs, it is crucial to be able to identify them early. OBJECTIVE: The aim of this study was to find all existing screening tools that identify patients with complex health needs at risk of frequent use of healthcare services, and to highlight their principal characteristics...
2017: PloS One
https://www.readbyqxmd.com/read/29189723/long-non-coding-rnas-in-metabolic-organs-and-energy-homeostasis
#11
REVIEW
Maude Giroud, Marcel Scheideler
Single cell organisms can surprisingly exceed the number of human protein-coding genes, which are thus not at the origin of the complexity of an organism. In contrast, the relative amount of non-protein-coding sequences increases consistently with organismal complexity. Moreover, the mammalian transcriptome predominantly comprises non-(protein)-coding RNAs (ncRNA), of which the long ncRNAs (lncRNAs) constitute the most abundant part. lncRNAs are highly species- and tissue-specific with very versatile modes of action in accordance with their binding to a large spectrum of molecules and their diverse localization...
November 30, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29189203/proteomic-characterization-of-human-exhaled-breath-condensate
#12
Maud Lacombe, Caroline Marie-Desvergne, Florence Combes, Alexandra Kraut, Christophe Bruley, Yves Vandenbrouck, Véronique Chamel Mossuz, Yohann Couté, Virginie Brun
To improve biomedical knowledge and to support biomarker discovery studies, it is essential to establish comprehensive proteome maps for human tissues and biofluids, and to make them publicly accessible. In this study, we performed an in-depth proteomics characterization of exhaled breath condensate (EBC), a sample obtained non-invasively by condensation of exhaled air that contains submicron droplets of airway lining fluid. Two pooled samples of EBC, each obtained from 10 healthy donors, were processed using a straightforward protocol based on sample lyophilization, in-gel digestion and liquid chromatography tandem-mass spectrometry (LC-MS/MS) analysis...
November 30, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29185930/impact-of-sourdough-fermentation-on-appetite-and-postprandial-metabolic-responses-a-randomised-cross-over-trial-with-whole-grain-rye-crispbread
#13
Galia Zamaratskaia, Daniel P Johansson, Matheus Antunes Junqueira, Linda Deissler, Maud Langton, Per M Hellström, Rikard Landberg
Sourdough fermentation is considered to have beneficial effects on postprandial satiety and metabolic responses, but studies demonstrating effects at physiological conditions are lacking. The aim of this acute breakfast intervention study was to determine the effect of consumption of sourdough-fermented and unfermented rye crispbread on self-rated appetite, postprandial glucose and insulin response in healthy subjects. In all, twenty-four Swedish adults were included in a single-blinded, randomised cross-over trial...
November 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/29180281/insertion-sequence-transpositions-and-point-mutations-in-mgrb-causing-colistin-resistance-in-a-clinical-strain-of-carbapenem-resistant-klebsiella-pneumoniae-from-vietnam
#14
Björn Berglund, Ngoc Thi Bich Hoang, Maria Tärnberg, Ngai Kien Le, Olov Svartström, Dung Thi Khanh Khu, Maud Nilsson, Hai Thanh Le, Jenny Welander, Linus Olson, Mattias Larsson, Lennart E Nilsson, Håkan Hanberger
Resistance among Klebsiella pneumoniae to the last resort antibiotics carbapenems and colistin is increasing worldwide. In this study, we used whole-genome sequencing to determine the colistin resistance mechanisms in clinical isolates of carbapenem- and colistin-resistant K. pneumoniae from Vietnam. Alterations in the regulatory gene mgrB, via mutations and insertion sequence transpositions, was found in 30 of 31 isolates, emphasizing the importance of this resistance mechanism in colistin-resistant K. pneumoniae...
November 24, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29178916/do-hedonic-versus-nutrition-based-attitudes-toward-food-predict-food-choices-a-cross-sectional-study-of-6-to-11-year-olds
#15
Lucile Marty, Maud Miguet, Marie Bournez, Sophie Nicklaus, Stéphanie Chambaron, Sandrine Monnery-Patris
BACKGROUND: Implicit and explicit attitudes are potential precursors of food choices and combine affective and cognitive components that can vary in their relative dominance. Yet, the affective and cognitive components of attitudes toward food can lead to distinct predisposition toward a food item and potentially to different food choices. In the food domain, the affective component pertains to the hedonic tone of consumption, while the cognitive component encompasses nutritional value or health consequences of food...
November 25, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/29176769/decreased-prevalence-of-cancer-in-patients-with-multiple-sclerosis-a-case-control-study
#16
Xavier Moisset, Maud Perié, Bruno Pereira, Emilie Dumont, Christine Lebrun-Frenay, François-Xavier Lesage, Frederic Dutheil, Frederic Taithe, Pierre Clavelou
BACKGROUND: Studies of cancer prevalence have produced conflicting results concerning the relative risk of overall and specific sub-types of cancer in patients with multiple sclerosis (MS). Contemporary controls and information on tobacco use and alcohol consumption are generally missing from previous studies. OBJECTIVES: To evaluate lifetime cancer prevalence in a large cohort of MS patients relative to appropriate controls. METHODS: We conducted a case-control study, using a postal survey of a cohort of MS patients...
2017: PloS One
https://www.readbyqxmd.com/read/29176353/new-developments-in-immunotherapy-for-pediatric-leukemia
#17
Jessica B Foster, Shannon L Maude
PURPOSE OF REVIEW: Immunotherapy for the treatment of cancer has advanced at a tremendous pace over the last decade. In this review, we provide an overview of recent progress in immunotherapy for the treatment of leukemia, focusing on antibody-drug conjugates (ADC), bi-specific T-cell engagers (BiTE), and chimeric antigen receptor (CAR) T cells. RECENT FINDINGS: Ongoing clinical trials of CAR T cells directed against CD19 have produced complete remission rates as high as 93%, prompting global multicenter phase 2 trials and the first FDA approval of a CAR T-cell therapy...
November 15, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29175168/cd8-t-cells-are-essential-for-the-effects-of-enriched-environment-on-hippocampus-dependent-behavior-hippocampal-neurogenesis-and-synaptic-plasticity
#18
Hadi Zarif, Sarah Nicolas, Mélanie Guyot, Salma Hosseiny, Anne Lazzari, María Magdalena Canali, Julie Cazareth, Frédéric Brau, Valentine Golzné, Elisa Dourneau, Maud Maillaut, Carmelo Luci, Agnès Paquet, Kevin Lebrigand, Marie-Jeanne Arguel, Douglas Daoudlarian, Catherine Heurteaux, Nicolas Glaichenhaus, Joëlle Chabry, Alice Guyon, Agnès Petit-Paitel
Enriched environment (EE) induces plasticity changes in the brain. Recently, CD4+ T cells have been shown to be involved in brain plasticity processes. Here, we show that CD8+ T cells are required for EE-induced brain plasticity in mice, as revealed by measurements of hippocampal volume, neurogenesis in the DG of the hippocampus, spinogenesis and glutamatergic synaptic function in the CA of the hippocampus. As a consequence, EE-induced behavioral benefits depend, at least in part, on CD8+ T cells. In addition, we show that spleen CD8+ T cells from mice housed in standard environment (SE) and EE have different properties in terms of 1) TNFα release after in vitro CD3/CD28 or PMA/Iono stimulation 2) in vitro proliferation properties 3) CD8+ CD44+ CD62Llow and CD62Lhi T cells repartition 4) transcriptomic signature as revealed by RNA sequencing...
November 21, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29171139/randomized-double-blind-placebo-controlled-dose-finding-study-of-the-dipeptidyl-peptidase-4-inhibitor-linagliptin-in-pediatric-patients-with-type-2-diabetes
#19
William V Tamborlane, Lori Mb Laffel, Jacques Weill, Maud Gordat, Dietmar Neubacher, Silke Retlich, Willem Hettema, Cornelia E Hoesl, Stefan Kaspers, Jan Marquard
OBJECTIVE: To identify the dose of the dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin in pediatric patients with type 2 diabetes (T2D). METHODS: Double-blind, randomized, controlled parallel group study comparing linagliptin 1 and 5 mg once daily, with placebo in 39 patients with T2D aged 10 to below 18 years. The primary efficacy endpoint was the change from baseline in glycated hemoglobin (HbA1c) after 12 weeks of treatment. The key pharmacodynamic endpoint was DPP-4 inhibition during steady-state...
November 24, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29170192/car-emissions-cytokines-tell-the-story
#20
Shannon L Maude
No abstract text is available yet for this article.
November 23, 2017: Blood
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