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Michiel J E G W Vanfleteren, Maud Koopman, Martijn A Spruit, Herman-Jan Pennings, Frank Smeenk, Willem Pieters, Jan J A M van den Bergh, Arent-Jan Michels, Emiel F M Wouters, Miriam T J Groenen, Frits M E Franssen, Lowie E G W Vanfleteren
OBJECTIVE: To evaluate the effect of pulmonary rehabilitation (PR) on exercise performance and quality of life in patients with chronic obstructive pulmonary disease (COPD) with different degrees of static lung hyperinflation (LH). DESIGN: Retrospective cohort study. SETTING: Pulmonary Rehabilitation Network. PARTICIPANTS: A cohort of 1981 patients with COPD (55% males; age: 66.8 ± 9.3y; FEV1%: 50.7 ± 19.5; RV%: 163...
June 12, 2018: Archives of Physical Medicine and Rehabilitation
Philippe Hogan, Roxane Plourde, Maude Fortier, Dave Brindamour, Colin Lagrenade-Verdant, Simon Demers-Marcil, Sébastien Dupuis
A 56-year-old woman with septic shock presented with persistent hyperlactatemia, despite an adequate clinical response to treatment. Carnitine deficiency was suspected, as the patient was malnourished and chronically taking valproic acid. No other plausible cause of hyperlactatemia was found. Carnitine supplementation resulted in rapid normalization of lactatemia.
January 1, 2018: Journal of Pharmacy Practice
Sandra Krohn, Katharina Zeller, Stephan Böhm, Antonis Chatzinotas, Hauke Harms, Jan Hartmann, Anett Heidtmann, Adam Herber, Thorsten Kaiser, Maud Treuheit, Albrecht Hoffmeister, Thomas Berg, Cornelius Engelmann
Patients with liver cirrhosis are susceptible to fungal infections. Due to low sensitivity of culture-based methods, we applied a real-time PCR assay targeting the 18S rRNA gene in combination with direct sequencing and terminal-restriction fragment length polymorphism (T-RFLP) in order to establish a novel tool to detect fungal DNA and to quantify and differentiate Candida DNA, also in polyfungal specimens. In total, 281 samples (blood n = 135, ascites n = 92, duodenal fluid n = 54) from 135 patients with liver cirrhosis and 52 samples (blood n = 26, duodenal fluid n = 26) from 26 control patients were collected prospectively...
2018: PloS One
Sonia Dollfus, Nemat Jaafari, Olivier Guillin, Benoit Trojak, Marion Plaze, Ghassen Saba, Cécilia Nauczyciel, Aurélie Montagne Larmurier, Nathalie Chastan, Vincent Meille, Marie-Odile Krebs, Samar S Ayache, Jean Pascal Lefaucheur, Annick Razafimandimby, Elise Leroux, Rémy Morello, Jean Marie Batail, Perrine Brazo, Nicolas Lafay, Issa Wassouf, Ghina Harika-Germaneau, Remy Guillevin, Carole Guillevin, Emmanuel Gerardin, Maud Rotharmel, Benoit Crépon, Raphael Gaillard, Christophe Delmas, Gael Fouldrin, Guillaume Laurent, Clément Nathou, Olivier Etard
INTRODUCTION: Despite extensive testing, the efficacy of low-frequency (1 Hz) repetitive transcranial magnetic stimulation (rTMS) of temporo-parietal targets for the treatment of auditory verbal hallucinations (AVH) in patients with schizophrenia is still controversial, but promising results have been reported with both high-frequency and neuronavigated rTMS. Here, we report a double-blind sham-controlled study to assess the efficacy of high-frequency (20 Hz) rTMS applied over a precise anatomical site in the left temporal region using neuronavigation...
April 6, 2018: Schizophrenia Bulletin
Marketa Kaucka, Julian Petersen, Marketa Tesarova, Bara Szarowska, Maria Eleni Kastriti, Meng Xie, Anna Kicheva, Karl Annusver, Maria Kasper, Orsolya Symmons, Leslie Pan, Francois Spitz, Jozef Kaiser, Maria Hovorakova, Tomas Zikmund, Kazunori Sunadome, Michael P Matise, Hui Wang, Ulrika Marklund, Hind Abdo, Patrik Ernfors, Pascal Maire, Maud Wurmser, Andrei S Chagin, Kaj Fried, Igor Adameyko
Facial shape is the basis for facial recognition and categorization. Facial features reflect the underlying geometry of the skeletal structures. Here we reveal that cartilaginous nasal capsule (corresponding to upper jaw and face) is shaped by signals generated by neural structures: brain and olfactory epithelium. Brain-derived Sonic Hedgehog (SHH) enables the induction of nasal septum and posterior nasal capsule, whereas the formation of a capsule roof is controlled by signals from the olfactory epithelium...
June 13, 2018: ELife
Camille Bastien Tardif, Maude Cantin, Sylvain Sénécal, Pierre-Majorique Léger, Élise Labonté-Lemoyne, Mickael Begon, Marie-Eve Mathieu
Sedentary behaviors are an important issue worldwide, as prolonged sitting time has been associated with health problems. Recently, active workstations have been developed as a strategy to counteract sedentary behaviors. The present study examined the rationale and perceptions of university students’ and staff following their first use of an active workstation in library settings. Ninety-nine volunteers completed a self-administered questionnaire after using a portable pedal exercise machine (PPEM) or a standing desk (SD)...
June 12, 2018: International Journal of Environmental Research and Public Health
Brian J Nguyen, Ashley Burt, Randall L Baldassare, Edward Smitaman, Maud Morshedi, Steven Kao, Eric Y Chang, Sebastian Obrzut
OBJECTIVE: The objective of this study was to assess the clinical significance of increased fluorine-18-fluorodeoxyglucose (F-FDG) uptake on PET/CT in joints for evaluation of symptomatic osteoarthritis (OA) and prediction of progression. PATIENTS AND METHODS: In this prospective study, shoulder, hip, and knee joints were imaged in 65 patients undergoing routine F-FDG PET/CT imaging. Patients completed the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire to assess joint pain, stiffness, and physical function...
July 2018: Nuclear Medicine Communications
Silvia E Tritz, Vilaysone Khounvisith, Sisavath Pommasichan, Khampasong Ninnasopha, Amphone Keosengthong, Vannaphone Phoutana, Margot Camoin, Judith M Hübschen, Antony P Black, Claude P Muller, Chantal J Snoeck, Maude Pauly
Although pigs are the main reservoir, ruminants have also been shown to be susceptible to hepatitis E virus (HEV). We investigated zoonotic transmission of HEV in rural settings of Lao People's Democratic Republic (Lao PDR) where humans are in close contacts with ruminants and where pigs are rare. Villagers with (n = 171, risk group) and without (n = 155, control group) cattle were recruited in seven villages in Vientiane Capital. Owners of pigs were excluded. Blood, as well as information on socio-demographics, animal contact, dietary habits and awareness of zoonoses were collected to assess risk factors...
June 10, 2018: Zoonoses and Public Health
Julien Ghelfi, Alexandre Moreau-Gaudry, Nikolai Hungr, Céline Fouard, Baptiste Véron, Maud Medici, Emilie Chipon, Philippe Cinquin, Ivan Bricault
PURPOSE: To assess the accuracy of Light Puncture Robot (LPR) as a patient-mounted robot, in positioning a sham needle under MRI guidance for abdominal percutaneous interventions. MATERIALS AND METHODS: This monocentric, prospective and non-controlled study was approved by the ethics review board. The study evaluated the accuracy of LPR V3 to achieve a virtual puncture in 20 healthy volunteers. Three trajectories were tried on each volunteer, under 3-T MRI guidance...
June 6, 2018: Cardiovascular and Interventional Radiology
Obinna Ositadimma Oleribe, Babatunde Lawal Salako, Albert Akpalu, Emmanuel Anteyi, Mamadou Mourtalla Ka, Gibrilla Deen, Temilola Akande, Mei Ran Abellona U, Maud Lemoine, Mairi McConnochie, Matthew Foster, Richard Walker, Simon David Taylor-Robinson, Ali Jawad
Introduction: in-service training of healthcare workers is essential for improving healthcare services and outcome. Methods: The Millennium Development Goal (MDG) 6 Partnership for African Clinical Training (M-PACT) program was an innovative in-service training approach designed and implemented by the Royal College of Physicians (RCP) and West African College of Physicians (WACP) with funding from Eco Bank Foundation. The goal was to develop sustainable capacity to tackle MDG 6 targets in West Africa through better postgraduate medical education...
2018: Pan African Medical Journal
Marie-Catherine Vozenin, Pauline De Fornel, Kristoffer Petersson, Vincent Favaudon, Maud Jaccard, Jean-François Germond, Benoit Petit, Marco Burki, Gisèle Ferrand, David Patin, Hanan Bouchaab, Mahmut Ozsahin, François Bochud, Claude Bailat, Patrick Devauchelle, Jean Bourhis
BACKGROUND: Previous studies using FLASH radiotherapy (RT) in mice showed a marked increase of the differential effect between normal tissue and tumors. To stimulate clinical transfer, we evaluated whether this effect could also occur in higher mammals. METHODS: Pig skin was used to investigate a potential difference in toxicity between irradiation delivered at ultra-high dose rate called FLASH-RT and irradiation delivered at conventional dose rate called Conv-RT...
June 6, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Maud Debaugnies, Adriana Sánchez-Danés, Sandrine Rorive, Maylis Raphaël, Mélanie Liagre, Marie-Astrid Parent, Audrey Brisebarre, Isabelle Salmon, Cédric Blanpain
YAP and TAZ are key downstream regulators of the Hippo pathway, regulating cell proliferation and differentiation. YAP and TAZ activation has been reported in different cancer types. However, it remains unclear whether they are required for the initiation of major skin malignancies like basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Here, we analyze the expression of YAP and TAZ in these skin cancers and evaluate cancer initiation in knockout mouse models. We show that YAP and TAZ are nuclear and highly expressed in different BCC types in both human and mice...
June 6, 2018: EMBO Reports
Marc Le Fort, Maude Espagnacq, Thierry Albert, Chloë Lefèvre, Brigitte Perrouin-Verbe, Jean-François Ravaud
Background: Pressure ulcer risk assessment provides an indicator of quality of care in French health establishments. The reliability and validity of assessment tools have been shown to be lower for people with spinal cord injury (SCI). We hypothesized that skin complications would be less frequent in people with traumatic SCI and tetraplegia (TSCIt), who were initially managed in French regions with a high level of specialized SCI rehabilitation experience. Methods: First, we used the most recent French territorial survey about SCI to determine a 'Level of Regional Experience (LRE) in Specialized Physical Medicine and Rehabilitation'...
June 4, 2018: European Journal of Public Health
Sabrina Morin Chabane, Franzina Coutinho, Maude Laliberte, Debbie Feldman
PURPOSE: To conduct a knowledge translation exercise by sharing knowledge from a scoping review, describing physiotherapists' attitudes toward and beliefs about chronic pain, and to gain perspectives on these findings from physiotherapists working with this clientele. METHOD: We conducted three focus groups with a total of 14 outpatient physiotherapists working in public hospitals. We first showed a video (reflecting an encounter between a clinician and a person living with chronic pain) created based on themes that emerged from a scoping review we conducted, followed by a discussion about attitudes and beliefs toward chronic pain...
June 6, 2018: Physiotherapy Theory and Practice
Mary T Paterno, Maud Low, Aline Gubrium, Kirk Sanger
Substance use disorders (SUDs) are a growing problem for pregnant and parenting women. Woman-to-woman peer support may positively influence perinatal outcomes but little is known about the impact of such support on the women who are providing support. The purpose of this study was to describe experiences of addiction in pregnancy, recovery, and subsequently serving as a peer mentor to other pregnant women with active SUD among women in recovery in a rural setting. We conducted one digital storytelling workshop with five women serving as peer mentors with lived experience of perinatal SUD...
June 1, 2018: Qualitative Health Research
Corrado Sandini, Daniela Zöller, Elisa Scariati, Maria C Padula, Maude Schneider, Marie Schaer, Dimitri Van De Ville, Stephan Eliez
Background: Schizophrenia is currently considered a neurodevelopmental disorder of connectivity. Still few studies have investigated how brain networks develop in children and adolescents who are at risk for developing psychosis. 22q11.2 Deletion Syndrome (22q11DS) offers a unique opportunity to investigate the pathogenesis of schizophrenia from a neurodevelopmental perspective. Structural covariance (SC) is a powerful approach to explore morphometric relations between brain regions that can furthermore detect biomarkers of psychosis, both in 22q11DS and in the general population...
2018: Frontiers in Neuroscience
Pierre-Olivier Gaudreault, Nadia Gosselin, Marjolaine Lafortune, Samuel Deslauriers-Gauthier, Nicolas Martin, Maude Bouchard, Jonathan Dubé, Jean-Marc Lina, Julien Doyon, Julie Carrier
Study Objectives: Sleep is a reliable indicator of cognitive health in older individuals. Sleep spindles (SS) are non-rapid-eye-movement (NREM) sleep oscillations implicated in sleep-dependent learning. Their generation imply a complex activation of the thalamo-cortico-thalamic loop. Since SS require neuronal synchrony, the integrity of the white matter (WM) underlying these connections is of major importance. During aging, both SS and WM undergo important changes. The goal of this study was to investigate whether WM integrity could predict the age-related reductions in SS characteristics...
May 31, 2018: Sleep
Pierre Pescheloche, Benoit Parmentier, Thevy Hor, Olivier Chamond, Maud Chabaud, Sabine Irtan, Georges Audry
INTRODUCTION: Fistulas are a common complication of hypospadias surgery; they are more frequent after mid-shaft and posterior hypospadias repair. Surgical treatment of fistula still remains challenging with a significant failure rate. The basic principle is to add layers between skin and neourethra in order to decrease the incidence of recurrent urethrocutaneous fistula (UCF). We report our experience of UCF repair using a vascularized tunica vaginalis flap (TVF) after posterior and mid-shaft hypospadias surgery...
May 21, 2018: Journal of Pediatric Urology
Bin Yao, Hong Kang, Ju Wang, Sicheng Zhou, Yang Gong
To facilitate preventing patient safety events, researchers have been using the Federal Drug Administration (FDA) Manufacturer and User Device Experience (MAUDE) database as a publicly accessible data source for retrieving reports of medical devices including Health Information Technology (HIT) devices. A combined search strategy built with keywords in several fields such as Generic Name, Brand Name and Manufacturer is commonly used to extract reports of specific classifications of devices in the MAUDE. However, another structured field, Classification Product Code, is rarely visited...
2018: Studies in Health Technology and Informatics
Richelle C Kosse, Marcel L Bouvy, Maud Daanen, Tjalling W de Vries, Ellen S Koster
Importance: For a considerable proportion of pediatric patients, atopic dermatitis symptoms persist into adolescence. Previous studies have focused mainly on (parents of) children, whereas little is known about adolescents with atopic dermatitis. Objective: To explore the beliefs, experiences, and preferences of adolescents with atopic dermatitis toward their treatment. Design, Setting, and Participants: We conducted a qualitative study employing focus group interviews of 15 adolescents (aged 12-18 years) who collected at least 1 prescription for topical corticosteroids in class 2 (moderately potent) or 3 (potent) in the preceding year...
May 30, 2018: JAMA Dermatology
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