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https://www.readbyqxmd.com/read/28535401/workforce-planning-and-training-in-obstetrics-and-gynaecology-across-europe-a-survey-of-national-trainee-societies
#1
Anna J M Aabakke, Alexandra Kristufkova, Charlotte Boyon, Laurids T Bune, Maud Van de Venne
OBJECTIVE(S): To describe the infrastructural differences in training in Obstetrics and Gynaecology (ObGyn) across Europe. STUDY DESIGN: Descriptive web-based survey of 31 national ObGyn trainee societies representing the 30 member countries of the European Network of Trainees in Obstetrics and Gynaecology. Answers were verified in a telephone interview and only countries which had completed the telephone interview were included in the final analysis. RESULTS: The final analysis included 28 of 31 societies representing 27 countries (response rate 90%)...
May 10, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28533441/trends-in-dna-methylation-with-age-replicate-across-diverse-human-populations
#2
Shyamalika Gopalan, Oana Carja, Maud Fagny, Etienne Patin, Justin W Myrick, Lisa M McEwen, Sarah M Mah, Michael S Kobor, Alain Froment, Marcus W Feldman, Lluis Quintana-Murci, Brenna M Henn
Aging is associated with widespread changes in genome-wide patterns of DNA methylation. Thousands of CpG sites whose tissue-specific methylation levels are strongly correlated with chronological age have been previously identified. However, the majority of these studies have focused primarily on cosmopolitan populations living in the developed world; it is not known if age-related patterns of DNA methylation at these loci are similar across a broad range of human genetic and ecological diversity. We investigated genome-wide methylation patterns using saliva- and whole blood-derived DNA from two traditionally hunting and gathering African populations: the Baka of the western Central African rainforest and the ≠Khomani San of the South African Kalahari Desert...
May 22, 2017: Genetics
https://www.readbyqxmd.com/read/28524859/mesenchymal-stem-cells-sense-mitochondria-released-from-damaged-cells-as-danger-signals-to-activate-their-rescue-properties
#3
Meriem Mahrouf-Yorgov, Lionel Augeul, Claire Crola Da Silva, Maud Jourdan, Muriel Rigolet, Sylvie Manin, René Ferrera, Michel Ovize, Adeline Henry, Aurélie Guguin, Jean-Paul Meningaud, Jean-Luc Dubois-Randé, Roberto Motterlini, Roberta Foresti, Anne-Marie Rodriguez
Mesenchymal stem cells (MSCs) protect tissues against cell death induced by ischemia/reperfusion insults. This therapeutic effect seems to be controlled by physiological cues released by the local microenvironment following injury. Recent lines of evidence indicate that MSC can communicate with their microenvironment through bidirectional exchanges of mitochondria. In particular, in vitro and in vivo studies report that MSCs rescue injured cells through delivery of their own mitochondria. However, the role of mitochondria conveyed from somatic cells to MSC remains unknown...
May 19, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28520967/in-vivo-models-of-human-immunodeficiency-virus-persistence-and-cure-strategies
#4
Christopher C Nixon, Maud Mavigner, Guido Silvestri, J Victor Garcia
Current HIV therapy is not curative regardless of how soon after infection it is initiated or how long it is administered, and therapy interruption almost invariably results in robust viral rebound. Human immunodeficiency virus persistence is therefore the major obstacle to a cure for AIDS. The testing and implementation of novel yet unproven approaches to HIV eradication that could compromise the health status of HIV-infected individuals might not be ethically warranted. Therefore, adequate in vitro and in vivo evidence of efficacy is needed to facilitate the clinical implementation of promising strategies for an HIV cure...
March 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28511184/are-we-overlooking-stroke-chameleons-a-retrospective-study-on-the-delayed-recognition-of-stroke-patients
#5
Pitcha Chompoopong, Nassir Rostambeigi, Darine Kassar, Alberto Maud, Ihtesham A Qureshi, Salvador Cruz-Flores, Gustavo J Rodriguez
BACKGROUND AND PURPOSE: New effective recanalization therapies are currently available for acute ischemic stroke; yet a vast majority of stroke patients are left untreated. The lack of early recognition may be because often times, stroke patients present with atypical manifestations that resemble other conditions (which are referred to as "stroke chameleons"). We set to study the proportion of patients with delayed stroke recognition in a single center. METHODS: We performed a retrospective analysis of a prospectively collected data over a 9-year period...
May 17, 2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28511005/characterization-of-l-theanine-excitatory-actions-on-hippocampal-neurons-towards-the-generation-of-novel-n-methyl-d-aspartate-receptor-modulators-based-on-its-backbone
#6
Fatiha Sebih, Matthieu Rousset, Salima Bellahouel, Marc Rolland, Marie Celeste de Jesus Ferreira, Janique Guiramand, Catherine Cohen-Solal, Gérard Barbanel, Thierry Cens, Mohammed Abouazza, Adrien Tassou, Maud Gratuze, Céline Meunier, Pierre Charnet, Michel Vignes, Valérie Rolland
L-Theanine (or L-γ-N-ethyl-glutamine) is the major amino acid found in Camellia sinensis. It has received much attention because of its pleiotropic physiological and pharmacological activities leading to health benefits in humans, especially. We describe here a new, easy, efficient and environmentally-friendly chemical synthesis of L-Theanine and L-γ-N-propyl-Gln and their corresponding D isomers. L-Theanine, and its derivatives obtained so far, exhibited partial co-agonistic action at N-methyl-D-aspartate (NMDA) receptors, with no detectable agonist effect at other glutamate receptors, on cultured hippocampal neurons...
May 16, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28509432/feasibility-assessment-of-shear-wave-elastography-to-lumbar-back-muscles-a-radioanatomic-study
#7
Maud Creze, Krystel Nyangoh Timoh, Olivier Gagey, Laurence Rocher, Marie-France Bellin, Marc Soubeyrand
INTRODUCTION: Low back pain is often associated with tensional changes in the paraspinal muscles detected by palpatory procedures. Shear wave elastography (SWE), recently introduced, allows the stiffness of muscles to be assessed non-invasively. The aim of our work was to study the feasibility of using SWE on the three main lumbar back muscles (multifidus, longissimus and iliocostalis) in vivo after analyzing their muscular architecture ex vivo. MATERIALS AND METHODS: We determined the orientation of fibers in the multifidus, longissimus and iliocotalis muscles in seven fresh cadavers using gross anatomy and B-Mode ultrasound imaging...
May 16, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28505394/1-2-4-triazole-3-thione-compounds-as-inhibitors-of-di-zinc-metallo-%C3%AE-lactamases
#8
Laurent Sevaille, Laurent Gavara, Carine Bebrone, Filomena De Luca, Lionel Nauton, Maud Achard, Paola Mercuri, Silvia Tanfoni, Luisa Borgianni, Carole Guyon, Pauline Lonjon, Gülhan Turan-Zitouni, Julia Dzieciolowski, Katja Becker, Lionel Bénard, Ciaran Condon, Ludovic Maillard, Jean Martinez, Jean-Marie Frère, Otto Dideberg, Moreno Galleni, Jean-Denis Docquier, Jean-François Hernandez
Metallo-β-lactamases (MBL) cause resistance of Gram-negative bacteria to β-lactam antibiotics and are of serious concern because they can inactivate the last-resort carbapenems and because MBL inhibitors of clinical value are still lacking. We have previously identified the original binding mode of a 4-amino-1,2,4-triazole-3-thione compound, IIIA, within the di-zinc active site of the L1 MBL. Here, we present the crystallographic structure of a complex of L1 with the corresponding non-amino compound IIIB...
May 15, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28501574/androgen-production-in-pediatric-adrenocortical-tumors-may-occur-via-both-the-classic-and-or-the-alternative-backdoor-pathway
#9
Nesa Marti, Jana Malikova, José A Galván, Maude Aebischer, Marco Janner, Zdenek Sumnik, Barbora Obermannova, Genevieve Escher, Aurel Perren, Christa E Flück
Children with adrenocortical tumors (ACTs) often present with virilization due to high tumoral androgen production, with dihydrotestosterone (DHT) as most potent androgen. Recent work revealed two pathways for DHT biosynthesis, the classic and the backdoor pathway. Usage of alternate routes for DHT production has been reported in castration-resistant prostate cancer, CAH and PCOS. To assess whether the backdoor pathway may contribute to the virilization of pediatric ACTs, we investigated seven children suffering from androgen producing tumors using steroid profiling and immunohistochemical expression studies...
May 10, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28499479/-different-perspectives-on-caring-for-a-child-in-an-infant-care-home
#10
Christine Castello
Caring for a child in an infant care home leads professionals to examine their practices. Perrine Hugel, manager of an infant care home, and Maud Léon, an auxiliary child health nurse in the same home, describes the nursing values which they implement on a daily basis to favour the wellbeing of the infant and support parenthood.
May 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28499065/not-sick-enough-experiences-of-carers-of-people-with-mental-illness-negotiating-care-for-their-relatives-with-mental-health-services
#11
Michael Olasoji, Phil Maude, Kay McCauley
AIM: The literature reporting experiences of relatives of people with mental illness regarding their interactions with mental health services identifies many commonalities. However, the actual experience of carers engaging the services and understanding health care systems remains a gap in the literature. The aim of this study was to explore the experiences of carers (of people with a severe mental illness) in a major area mental health service in Victoria Australia as they fulfil their caring role whilst negotiating support for their relative...
May 12, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/28494496/sensitivity-to-binocular-disparity-is-reduced-by-mild-traumatic-brain-injury
#12
Gunnar Schmidtmann, Tatiana Ruiz, Alexandre Reynaud, Daniel P Spiegel, Maude Laguë-Beauvais, Robert F Hess, Reza Farivar
Purpose: The impairment of visual functions is one of the most common complaints following mild traumatic brain injury (mTBI). Traumatic brain injury-associated visual deficits include blurred vision, reading problems, and eye strain. In addition, previous studies have found evidence that TBI can diminish early cortical visual processing, particularly for second-order stimuli. We investigated whether cortical processing of binocular disparity is also affected by mTBI. Methods: In order to investigate the influence of mTBI on global stereopsis, we measured the quick Disparity Sensitivity Function (qDSF) in 22 patients with mTBI...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28493890/transcriptome-wide-analysis-of-alternative-rna-splicing-events-in-epstein-barr-virus-associated-gastric-carcinomas
#13
Victoria E S Armero, Marie-Pier Tremblay, Andréa Allaire, Simon Boudreault, Camille Martenon-Brodeur, Cyntia Duval, Mathieu Durand, Elvy Lapointe, Philippe Thibault, Maude Tremblay-Létourneau, Jean-Pierre Perreault, Michelle S Scott, Martin Bisaillon
Multiple human diseases including cancer have been associated with a dysregulation in RNA splicing patterns. In the current study, modifications to the global RNA splicing landscape of cellular genes were investigated in the context of Epstein-Barr virus-associated gastric cancer. Global alterations to the RNA splicing landscape of cellular genes was examined in a large-scale screen from 295 primary gastric adenocarcinomas using high-throughput RNA sequencing data. RT-PCR analysis, mass spectrometry, and co-immunoprecipitation studies were also used to experimentally validate and investigate the differential alternative splicing (AS) events that were observed through RNA-seq studies...
2017: PloS One
https://www.readbyqxmd.com/read/28484441/molecular-demonstration-of-a-pneumocystis-outbreak-in-stem-cell-transplant-patients-evidence-for-transmission-in-the-daycare-center
#14
Christine Robin, Alexandre Alanio, Maud Gits-Muselli, Giulia la Martire, Frédéric Schlemmer, Françoise Botterel, Cécile Angebault, Mathieu Leclerc, Florence Beckerich, Rabah Redjoul, Cécile Pautas, Andrea Toma, Sébastien Maury, Stéphane Bretagne, Catherine Cordonnier
Pneumocystis jirovecii pneumonia (PCP) is a life-threatening infection in hematology. Although occasionally reported, the role of interhuman transmission of P. jirovecii in PCP, compared to that of reactivation, remains an unresolved question; the recommendation to isolate PCP patients in the hematology ward are not well evidence-based. Following an unexpected increase in the number of febrile pneumonia patients with P. jirovecii DNA detected in respiratory samples in our hematology ward, we explored 12 consecutive patients from November 2015 to May 2016...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28483360/regulation-of-growth-epigenetic-mechanisms
#15
Laurent Kappeler, Maud Clemessy, Sarah Saget, Lyvianne Decourtye, Yves Le Bouc
Organism development is controlled by both genetic programs and the environment to insure a reproductive success as adults. Linear growth is an important part of the development and is mostly controlled by genetic factors. However, the variability of height in a given species does not seem to be specifically associated with SNP. This suggests that environment may play a crucial role. In agreement, an important part of height-related genes present CpG island in their proximal promoter, indicating potential involvement of epigenetic mechanisms...
May 5, 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/28483042/reproducible-diagnostic-metabolites-in-plasma-from-typhoid-fever-patients-in-asia-and-africa
#16
Elin Näsström, Christopher M Parry, Nga Tran Vu Thieu, Rapeephan R Maude, Hanna K de Jong, Masako Fukushima, Olena Rzhepishevska, Florian Marks, Ursula Panzner, Justin Im, Hyonjin Jeon, Seeun Park, Zabeen Chaudhury, Aniruddha Ghose, Rasheda Samad, Tan Trinh Van, Anders Johansson, Arjen M Dondorp, Guy E Thwaites, Abul Faiz, Henrik Antti, Stephen Baker
Salmonella Typhi is the causative agent of typhoid. Typhoid is diagnosed by blood culture, a method that lacks sensitivity, portability and speed. We have previously shown that specific metabolomic profiles can be detected in the blood of typhoid patients from Nepal (Näsström et al., 2014). Here, we performed mass spectrometry on plasma from Bangladeshi and Senegalese patients with culture confirmed typhoid fever, clinically suspected typhoid, and other febrile diseases including malaria. After applying supervised pattern recognition modelling, we could significantly distinguish metabolite profiles in plasma from the culture confirmed typhoid patients...
May 9, 2017: ELife
https://www.readbyqxmd.com/read/28482908/curative-or-pre-emptive-adenovirus-specific-t-cell-transfer-from-matched-unrelated-or-third-party-haploidentical-donors-after-hsct-including-ucb-transplantations-a-successful-phase-i-ii-multicenter-clinical-trial
#17
Chongsheng Qian, Arnaud Campidelli, Yingying Wang, Huili Cai, Véronique Venard, Hélène Jeulin, Jean Hugues Dalle, Cécile Pochon, Maud D'aveni, Benedicte Bruno, Catherine Paillard, Stéphane Vigouroux, Charlotte Jubert, Patrice Ceballos, Aude Marie-Cardine, Claire Galambrun, Clément Cholle, Isabelle Clerc Urmes, Nadine Petitpain, Marcelo De Carvalho Bittencourt, Véronique Decot, Loïc Reppel, Alexandra Salmon, Laurence Clement, Danièle Bensoussan
BACKGROUND: Allogeneic hematopoietic stem cell transplantation (HSCT), the most widely used potentially curable cellular immunotherapeutic approach in the treatment of hematological malignancies, is limited by life-threatening complications: graft versus host disease (GVHD) and infections especially viral infections refractory to antiviral drugs. Adoptive transfer of virus-specific T cells is becoming an alternative treatment for infections following HSCT. We report here the results of a phase I/II multicenter study which includes a series of adenovirus-specific T cell (ADV-VST) infusion either from the HSCT donor or from a third party haploidentical donor for patients transplanted with umbilical cord blood (UCB)...
May 8, 2017: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/28479964/relationship-between-academic-performance-with-physical-psychosocial-lifestyle-and-sociodemographic-factors-in-female-undergraduate-students
#18
Marie-Maude Dubuc, Mylène Aubertin-Leheudre, Antony D Karelis
BACKGROUND: The purpose of this study was to investigate the relationship between physical, psychosocial, lifestyle and sociodemographic factors with academic performance in female undergraduate students. METHODS: One hundred undergraduate female students from the Faculty of Science at the University of Quebec at Montreal participated in this study (mean age = 24.4 ± 4.6 years old). All participants provided their university transcript and had to complete at least 45 course credits from their bachelor degree...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28461563/circulating-tumor-cells-with-aberrant-alk-copy-number-predict-progression-free-survival-during-crizotinib-treatment-in-alk-rearranged-non-small-cell-lung-cancer-patients
#19
Emma Pailler, Marianne Oulhen, Isabelle Borget, Jordi Remon, Kirsty Ross, Nathalie Auger, Fanny Billiot, Maud Ngo Camus, Frédéric Commo, Colin R Lindsay, David Planchard, Jean-Charles Soria, Benjamin Besse, Françoise Farace
The duration and magnitude of clinical response are unpredictable in ALK-rearranged non-small cell lung cancer (NSCLC) patients treated with crizotinib, although all patients invariably develop resistance. Here, we evaluated whether circulating tumor cells (CTC) with aberrant ALK-FISH patterns [ALK-rearrangement, ALK-copy number gain (ALK-CNG)] monitored on crizotinib could predict progression-free survival (PFS) in a cohort of ALK-rearranged patients. Thirty-nine ALK-rearranged NSCLC patients treated with crizotinib as first ALK inhibitor were recruited prospectively...
May 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28454882/new-frontiers-for-environmental-epidemiology-in-a-changing-world
#20
Cathryn Tonne, Xavier Basagaña, Basile Chaix, Maud Huynen, Perry Hystad, Tim S Nawrot, Remy Slama, Roel Vermeulen, Jennifer Weuve, Mark Nieuwenhuijsen
BACKGROUND: In the next 25years, transformative changes, in particular the rapid pace of technological development and data availability, will require environmental epidemiologists to prioritize what should (rather than could) be done to most effectively improve population health. OBJECTIVES: In this essay, we map out key driving forces that will shape environmental epidemiology in the next 25years. We also identify how the field should adapt to best take advantage of coming opportunities and prepare for challenges...
April 25, 2017: Environment International
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