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https://www.readbyqxmd.com/read/28626454/a-syst-omics-approach-to-ensuring-food-safety-and-reducing-the-economic-burden-of-salmonellosis
#1
Jean-Guillaume Emond-Rheault, Julie Jeukens, Luca Freschi, Irena Kukavica-Ibrulj, Brian Boyle, Marie-Josée Dupont, Anna Colavecchio, Virginie Barrere, Brigitte Cadieux, Gitanjali Arya, Sadjia Bekal, Chrystal Berry, Elton Burnett, Camille Cavestri, Travis K Chapin, Alanna Crouse, France Daigle, Michelle D Danyluk, Pascal Delaquis, Ken Dewar, Florence Doualla-Bell, Ismail Fliss, Karen Fong, Eric Fournier, Eelco Franz, Rafael Garduno, Alexander Gill, Samantha Gruenheid, Linda Harris, Carol B Huang, Hongsheng Huang, Roger Johnson, Yann Joly, Maud Kerhoas, Nguyet Kong, Gisèle Lapointe, Line Larivière, Stéphanie Loignon, Danielle Malo, Sylvain Moineau, Walid Mottawea, Kakali Mukhopadhyay, Céline Nadon, John Nash, Ida Ngueng Feze, Dele Ogunremi, Ann Perets, Ana V Pilar, Aleisha R Reimer, James Robertson, John Rohde, Kenneth E Sanderson, Lingqiao Song, Roger Stephan, Sandeep Tamber, Paul Thomassin, Denise Tremblay, Valentine Usongo, Caroline Vincent, Siyun Wang, Joel T Weadge, Martin Wiedmann, Lucas Wijnands, Emily D Wilson, Thomas Wittum, Catherine Yoshida, Khadija Youfsi, Lei Zhu, Bart C Weimer, Lawrence Goodridge, Roger C Levesque
The Salmonella Syst-OMICS consortium is sequencing 4,500 Salmonella genomes and building an analysis pipeline for the study of Salmonella genome evolution, antibiotic resistance and virulence genes. Metadata, including phenotypic as well as genomic data, for isolates of the collection are provided through the Salmonella Foodborne Syst-OMICS database (SalFoS), at https://salfos.ibis.ulaval.ca/. Here, we present our strategy and the analysis of the first 3,377 genomes. Our data will be used to draw potential links between strains found in fresh produce, humans, animals and the environment...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28624010/lupus-mastitis-as-a-first-manifestation-of-systemic-disease-about-two-cases-with-a-review-of-the-literature
#2
REVIEW
Béatrice Voizard, Lucie Lalonde, Lilia Maria Sanchez, Johanne Richard-Chesnay, Julie David, Maude Labelle, Mona El Khoury, Isabelle Trop
Lupus mastitis is an uncommon manifestation of systemic lupus erythematosus (SLE) that affects the subcutaneous fat in the breast, much like lupus panniculitis, but additionally involves the mammary gland. We report on two women for whom lupus mastitis was the initial manifestation of SLE and provide a literature review of 34 additional cases reported in the Anglo-Saxon and French literature since 1971, making this the largest review to date. Lupus mastitis (LM) can manifest clinically as subcutaneous masses that may be painful, or may present cutaneous involvement such as thickening and discolouration...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28618142/functional-diversity-and-redundancy-across-fish-gut-sediment-and-water-bacterial-communities
#3
Arthur Escalas, Marc Troussellier, Yuan Tong, Thierry Bouvier, Corinne Bouvier, Maud A Mouchet, Domingo Flores Hernandez, Julia Ramos Miranda, Jizhong Zhou, David Mouillot
This paper explores the functional diversity and redundancy in a bacterial metacommunity constituted of three habitats (sediment, water column and fish gut) in a coastal lagoon under anthropogenic pressure. We used comprehensive functional gene arrays covering a wide range of ecological processes and stress resistance genes to estimate the functional potential of bacterial communities. Then, we used diversity partitioning to characterize functional diversity and redundancy within (α), between (β) and across (γ) habitats...
June 15, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28616488/building-bridges-to-operationalise-one-health-a-sino-swedish-collaboration-to-tackle-antibiotic-resistance
#4
Otto Cars, Yonghong Xiao, Cecilia Stålsby Lundborg, Lennart E Nilsson, Jianzhong Shen, Qiang Sun, Zhenqiang Bi, Stefan Börjesson, Christina Greko, Yang Wang, Yuqing Liu, Jakob Ottoson, Xuewen Li, Maud Nilsson, Hong Yin, Zhenwang Bi, Beiwen Zheng, Xi Xia, Baoli Chen, Lilu Ding, Pan Sun, Oliver James Dyar, Anette Hulth, Göran Tomson
Antibiotic resistance is a complex global health challenge. The recent Global Action Plan on antimicrobial resistance highlights the importance of adopting One Health approaches that can cross traditional disciplinary boundaries. We report on the early experiences of a multisectoral Sino-Swedish research project that aims to address gaps in our current knowledge and seeks to improve the situation through system-wide interventions. Our research project is investigating antibiotic use and resistance in a rural area of China through a combination of epidemiological, health systems and laboratory investigations...
December 2016: One Health
https://www.readbyqxmd.com/read/28616067/selection-by-higher-order-effects-of-salinity-and-bacteria-on-early-life-stages-of-western-baltic-spring-spawning-herring
#5
Maude Poirier, Luisa Listmann, Olivia Roth
Habitat stratification by abiotic and biotic factors initiates divergence of populations and leads to ecological speciation. In contrast to fully marine waters, the Baltic Sea is stratified by a salinity gradient that strongly affects fish physiology, distribution, diversity and virulence of important marine pathogens. Animals thus face the challenge to simultaneously adapt to the concurrent salinity and cope with the selection imposed by the changing pathogenic virulence. Western Baltic spring-spawning herring (Clupea harengus) migrate to spawning grounds characterized by different salinities to which herring are supposedly adapted...
July 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28614401/hepatitis-b-testing-and-treatment-in-hiv-patients-in-the-gambia-compliance-with-international-guidelines-and-clinical-outcomes
#6
Gibril Ndow, Mindy L Gore, Yusuke Shimakawa, Penda Suso, Abdoulie Jatta, Saydiba Tamba, Amina Sow, Coumba Touré-Kane, Fouzia Sadiq, Saihou Sabally, Ramou Njie, Mark R Thursz, Maud Lemoine
BACKGROUND: Compliance with WHO guidelines on HBV screening and treatment in HIV-coinfected patients is often challenging in resource limited countries and has been poorly assessed in sub-Saharan Africa. METHODS: Between 2015 and 2016, we assessed physician's compliance with WHO guidelines on HIV-HBV coinfection in the largest HIV clinic in The Gambia, and the hepatic outcomes in HIV-HBV coinfected patients as compared to randomly selected HIV-monoinfected controls...
2017: PloS One
https://www.readbyqxmd.com/read/28607292/laparoscopic-total-colectomy-for-ulcerative-colitis-after-liver-transplantation-is-feasible
#7
Benjamin Darnis, Gilles Poncet, Maud Robert
Ulcero-haemorrhagic rectocolitis can occur after liver transplantation for sclerosing cholangitis. Total colectomy with or without proctectomy may be indicated in case of chronic drug-resistant colitis, dysplasia or cancer. Today, laparoscopic approach is the standard for such procedure in non-operated patients. We performed a completely laparoscopic total colectomy 5 years after a liver transplantation. There were a few peritoneal adherences, and we could safely perform the procedure almost as usual. It provided all the advantages of the laparoscopic approach in the post-operative course...
July 2017: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/28606119/molecular-epidemiology-of-avian-rotaviruses-group-a-and-d-shed-by-different-bird-species-in-nigeria
#8
Maude Pauly, Oluwole O Oni, Aurélie Sausy, Ademola A Owoade, Christopher A O Adeyefa, Claude P Muller, Judith M Hübschen, Chantal J Snoeck
BACKGROUND: Avian rotaviruses (RVs) cause gastrointestinal diseases of birds worldwide. However, prevalence, diversity, epidemiology and phylogeny of RVs remain largely under-investigated in Africa. METHODS: Fecal samples from 349 birds (158 symptomatic, 107 asymptomatic and 84 birds without recorded health status) were screened by reverse transcription PCR to detect RV groups A and D (RVA and RVD). Partial gene sequences of VP4, VP6, VP7 and NSP4 for RVA, and of VP6 and VP7 for RVD were obtained and analyzed to infer phylogenetic relationship...
June 12, 2017: Virology Journal
https://www.readbyqxmd.com/read/28603999/defect-healing-and-charge-transfer-mediated-valley-polarization-in-mos2-mose2-mos2-trilayer-van-der-waals-heterostructures
#9
Alessandro Surrente, Dumitru Dumcenco, Zhuo Yang, Agnieszka Kuc, Yu Jing, Thomas Heine, Yen-Cheng Kung, Duncan K Maude, Andras Kis, Paulina Plochocka
Monolayer transition metal dichalcogenides (TMDCs) grown by chemical vapor deposition (CVD) are plagued by a significantly lower optical quality compared to exfoliated TMDCs. In this work, we show that the optical quality of CVD-grown MoSe2 is completely recovered if the material is sandwiched in MoS2/MoSe2/MoS2 trilayer van der Waals heterostructures. We show by means of density functional theory that this remarkable and unexpected result is due to defect healing: S atoms of the more reactive MoS2 layers are donated to heal Se vacancy defects in the middle MoSe2 layer...
June 15, 2017: Nano Letters
https://www.readbyqxmd.com/read/28602281/on-line-gaseous-formaldehyde-detection-by-a-microfluidic-analytical-method-based-on-simultaneous-uptake-and-derivatization-in-a-temperature-controlled-annular-flow
#10
Maud Guglielmino, Pierre Bernhardt, Claire Trocquet, Christophe A Serra, Stéphane Le Calvé
This paper is focused on the improvement of a microfluidic analytical method for the detection of low airborne formaldehyde concentrations, based on only two distinct steps permitting to reduce the response time and to improve the compactness of the device. First, gaseous formaldehyde is trapped into an acetylacetone solution at 65°C through an annular liquid/gas flow and reacts immediately to form 3,5-Diacetyl-1,4-dihydrolutidine which is then quantified by colorimetry using a liquid core waveguide (LCW)...
September 1, 2017: Talanta
https://www.readbyqxmd.com/read/28601705/abvd-or-beacoppbaseline-along-with-involved-field-radiotherapy-in-early-stage-hodgkin-lymphoma-with-risk-factors-results-of-the-european-organisation-for-research-and-treatment-of-cancer-eortc-groupe-d-%C3%A3-tude-des-lymphomes-de-l-adulte-gela-h9-u-intergroup-randomised
#11
Christophe Fermé, José Thomas, Pauline Brice, Olivier Casasnovas, Andrej Vranovsky, Serge Bologna, Pieternella J Lugtenburg, Réda Bouabdallah, Patrice Carde, Catherine Sebban, Houchingue Eghbali, Gilles Salles, Gustaaf W van Imhoff, Antoine Thyss, Evert M Noordijk, Oumédaly Reman, Marnix L M Lybeert, Maud Janvier, Michele Spina, Bruno Audhuy, John M M Raemaekers, Richard Delarue, Bruno Anglaret, Okke de Weerdt, Zora Marjanovic, Robbert J H A Tersteeg, Daphne de Jong, Josette Brière, Michel Henry-Amar
PURPOSE: For early-stage Hodgkin lymphoma (HL), optimal chemotherapy regimen and the number of cycles to be delivered remain to settle down. The H9-U trial compared three modalities of chemotherapy followed by involved-field radiotherapy (IFRT) in patients with stage I-II HL and risk factors (NCT00005584). PATIENTS AND METHODS: Patients aged 15-70 years with untreated supradiaphragmatic HL with at least one risk factor (age ≥ 50, involvement of 4-5 nodal areas, mediastinum/thoracic ratio ≥ 0...
June 7, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28601694/feeling-happy-when-feeling-down-the-effectiveness-of-positive-mental-imagery-in-dysphoria
#12
Maud Grol, Naomi Vanlessen, Rudi De Raedt
BACKGROUND AND OBJECTIVES: Mental imagery can evoke strong emotional responses, but imagery perspective can influence the response, with observer perspective reducing emotionality. This is important provided that positive imagery can be an effective mood repair strategy in healthy individuals. However, (sub-clinical) depressed individuals tend to spontaneously adopt an observer perspective. We investigated whether positive imagery would result in a similar emotional response in dysphoric and non-dysphoric individuals when instructed and trained to use field perspective imagery...
May 31, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28600477/targeting-the-wnt-pathway-and-cancer-stem-cells-with-anti-progastrin-humanized-antibodies-a-major-breakthrough-for-k-ras-mutated-colorectal-cancer-treatment
#13
Alexandre Prieur, Monica Cappellini, Guillaume Habif, Marie-Paule Lefranc, Thibault Mazard, Eric Morency, Jean-Marc Pascussi, Maud Flaceliere, Nathalie Cahuzac, Berengere Vire, Benjamin Dubuc, Amandine Durochat, Pierre Liaud, Jérémy Ollier, Caroline Pfeiffer, Sophie Poupeau, Véronique Saywell, Chris Planque, Eric Assenat, Frédéric Bibeau, Jean-François Bourgaux, Pascal Pujol, Alain Sézeur, Marc Ychou, Dominique Joubert
<p>Patients with metastatic colorectal cancer (CRC) suffer from disease relapse mainly due to cancer stem cells (CSC). Interestingly, they have an increased level of blood progastrin, a tumor-promoting peptide essential for the self-renewal of colon CSCs, which is also a direct b-catenin/Tcf4 target gene. In this study we aimed to develop a novel targeted therapy to neutralize secreted progastrin in order to inhibit Wnt signaling, CSCs and reduce relapses.</p> Experimental Design: <p>Antibodies (monoclonal and humanized) directed against progastrin were produced and selected for target specificity and affinity...
June 9, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28596508/promoter-hypomethylation-of-ny-eso-1-association-with-clinicopathological-features-and-pd-l1-expression-in-non-small-cell-lung-cancer
#14
Anderly C Chüeh, Mun-Sem Liew, Prudence A Russell, Marzena Walkiewicz, Aparna Jayachandran, Maud H W Starmans, Paul C Boutros, Gavin Wright, Stephen A Barnett, John M Mariadason, Thomas John
Cancer-Testis antigens (CTA) are immunogenic molecules with normal tissue expression restricted to testes but with aberrant expression in up to 30% of non-small cell lung cancers (NSCLCs). Regulation of CTA expression is mediated in part through promoter DNA methylation. Recently, immunotherapy has altered treatment paradigms in NSCLC. Given its immunogenicity and ability to be re-expressed through demethylation, NY-ESO-1 promoter methylation, protein expression and its association with programmed death receptor ligand-1 (PD-L1) expression and clinicopathological features were investigated...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28594680/antibiotic-therapy-in-comatose-mechanically-ventilated-patients-following-aspiration-differentiating-pneumonia-from-pneumonitis
#15
Jean Baptiste Lascarrou, Floriane Lissonde, Aurélie Le Thuaut, Konstantinos Bachoumas, Gwenhael Colin, Matthieu Henry Lagarrigue, Isabelle Vinatier, Maud Fiancette, Jean Claude Lacherade, Aihem Yehia, Aurélie Joret, Christine Lebert, Sandra Bourdon, Laurent Martin Lefèvre, Jean Reignier
OBJECTIVES: To determine the proportion of patients with documented bacterial aspiration pneumonia among comatose ICU patients with symptoms suggesting either bacterial aspiration pneumonia or non-bacterial aspiration pneumonitis. DESIGN: Prospective observational study. SETTING: University-affiliated 30-bed ICU. PATIENTS: Prospective cohort of 250 patients admitted to the ICU with coma (Glasgow Coma Scale score ≤ 8) and treated with invasive mechanical ventilation...
June 7, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28594293/the-shiva01-trial-what-have-we-learned
#16
Christophe Le Tourneau, Maud Kamal, Ivan Bièche
No abstract text is available yet for this article.
June 8, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28592679/glacial-survival-of-trophically-linked-boreal-species-in-northern-europe
#17
Maud C Quinzin, Signe Normand, Simon Dellicour, Jens-Christian Svenning, Patrick Mardulyn
Whether non-arctic species persisted in northern Europe during the Last Glacial Maximum (LGM) is highly debated. Until now, the debate has mostly focused on plants, with little consideration for other groups of organisms, e.g. the numerous plant-dependent insect species. Here, we study the late-Quaternary evolution of the European range of a boreo-montane leaf beetle, Gonioctena intermedia, which feeds exclusively on the boreal and temperate trees Prunus padus and Sorbus aucuparia Using species distribution models, we estimated the congruence between areas of past and present suitable climate for this beetle and its host plants...
June 14, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28591631/gut-brain-glucose-signaling-in-energy-homeostasis
#18
REVIEW
Maud Soty, Amandine Gautier-Stein, Fabienne Rajas, Gilles Mithieux
Intestinal gluconeogenesis is a recently identified function influencing energy homeostasis. Intestinal gluconeogenesis induced by specific nutrients releases glucose, which is sensed by the nervous system surrounding the portal vein. This initiates a signal positively influencing parameters involved in glucose control and energy management controlled by the brain. This knowledge has extended our vision of the gut-brain axis, classically ascribed to gastrointestinal hormones. Our work raises several questions relating to the conditions under which intestinal gluconeogenesis proceeds and may provide its metabolic benefits...
June 6, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28588873/a-72-year-old-with-eyelid-opening-apraxia-in-steele-richardson-olszewski-syndrome
#19
Ihtesham A Qureshi, Mohtashim A Qureshi, Alberto Maud
In our patient with Steele-Richardson-Olszewski syndrome presenting with apraxia of eyelid opening, there is a possibility to be readily confused with conditions presenting in similar pattern such as blepharospasm and eyelid ptosis. Therefore, it is essential to correlate the clinical findings with electromyographic recordings and dopamine transporter scan (DaT).
June 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28583155/molecular-diagnosis-of-pseudoterranova-decipiens-s-s-in-human-france
#20
Julie Brunet, Bernard Pesson, Maude Royant, Jean-Philippe Lemoine, Alexander W Pfaff, Ahmed Abou-Bacar, Hélène Yera, Emilie Fréalle, Jean Dupouy-Camet, Gema Merino-Espinosa, Magdalena Gómez-Mateos, Joaquina Martin-Sanchez, Ermanno Candolfi
BACKGROUND: Anisakis and Pseudoterranova are the main genera involved in human infections caused by nematodes of the Anisakidae family. Species identification is complicated due to the lack of differential morphological characteristics at the larval stage, thus requiring molecular differentiation. Pseudoterranova larvae ingested through raw fish are spontaneously eliminated in most cases, but mechanical removal by means of endoscopy might be required. To date, only very few cases of Pseudoterranova infection have been reported in France...
June 6, 2017: BMC Infectious Diseases
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