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https://www.readbyqxmd.com/read/29674064/determination-of-eight-carbonyl-compounds-in-aerosols-trapped-in-phosphate-buffer-saline-solutions-to-support-in-vitro-assessment-studies
#1
Roberto Buratto, Daniela Correia, Monique Parel, Maude Crenna, Mickaël Bilger, Audrey Debrick
When investigating the toxicological impact of aerosols using in vitro systems like cell cultures, it is essential to have a quantitative measurement of the chemicals that the cells are exposed to. Carbonyl compounds represent an important class of marker compounds for in vitro and in vivo exposure to different toxicological agents, including cigarette smoke (CS). A new LC-MS/MS method that quantifies eight of these analytes in aerosols trapped in phosphate-buffered saline solutions has been developed to measure exposure...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29671174/increased-overall-survival-after-introduction-of-structured-bedside-consultation-in-staphylococcus-aureus-bacteraemia
#2
Maud B P A Ariaans, Elisabeth A Roovers, Mark A A Claassen, Robert-Jan Hassing, Caroline M A Swanink, Elisabeth H Gisolf
Staphylococcus aureus bacteraemia (SAB) is a common and severe disease. In 2012, a structured bedside consultation (SBC) was introduced at Rijnstate Hospital. We analysed the effect of this SBC on the overall survival of patients with SAB and the effect on the diagnostic workup. We performed a retrospective cohort study, including all patients over 18 years with SAB from 2009 until 2017. The cases preceding versus those after implementation of SBC in 2012 were compared. In total, 613 episodes of SAB were analysed: 234 cases before and 379 cases since SBC...
April 18, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29669777/false-positive-results-following-lentiviral-based-tisagenlecleucel-therapy-with-select-hiv-1-nat-methods
#3
Theodore W Laetsch, Shannon L Maude, Michael C Milone, Kara L Davis, Joerg Krueger, Ana Maria Cardenas, Lamis K Eldjerou, Christopher H Keir, Patricia A Wood, Stephan A Grupp
No abstract text is available yet for this article.
April 18, 2018: Blood
https://www.readbyqxmd.com/read/29667094/worldwide-experience-with-erosion-of-the-magnetic-sphincter-augmentation-device
#4
Evan T Alicuben, Reginald C W Bell, Blair A Jobe, F P Buckley, C Daniel Smith, Casey J Graybeal, John C Lipham
BACKGROUND: The magnetic sphincter augmentation device continues to become a more common antireflux surgical option with low complication rates. Erosion into the esophagus is an important complication to recognize and is reported to occur at very low incidences (0.1-0.15%). Characterization of this complication remains limited. We aim to describe the worldwide experience with erosion of the magnetic sphincter augmentation device including presentation, techniques for removal, and possible risk factors...
April 17, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29659963/saturated-fats-from-butter-but-not-from-cheese-increase-hdl-mediated-cholesterol-efflux-capacity-from-j774-macrophages-in-men-and-women-with-abdominal-obesity
#5
Didier Brassard, Benoît J Arsenault, Marjorie Boyer, Daniela Bernic, Maude Tessier-Grenier, Denis Talbot, Angelo Tremblay, Emile Levy, Bela Asztalos, Peter J H Jones, Patrick Couture, Benoît Lamarche
Background: Recent evidence suggests that the association between dietary saturated fatty acids (SFAs) and coronary artery disease risk varies according to food sources. How SFAs from butter and cheese influence HDL-mediated cholesterol efflux capacity (CEC), a key process in reverse cholesterol transport, is currently unknown. Objective: In a predefined secondary analysis of a previously published trial, we have examined how diets rich in SFAs from either cheese or butter influence HDL-mediated CEC, compared with diets rich in either monounsaturated fatty acids (MUFAs) or polyunsaturated fatty acids (PUFAs)...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29658882/transcriptomic-analyses-reveal-rhythmic-and-clock-driven-pathways-in-human-skeletal-muscle
#6
Laurent Perrin, Ursula Loizides-Mangold, Stéphanie Chanon, Cédric Gobet, Nicolas Hulo, Laura Isenegger, Benjamin D Weger, Eugenia Migliavacca, Aline Charpagne, James A Betts, Jean-Philippe Walhin, Iain Templeman, Keith Stokes, Dylan Thompson, Kostas Tsintzas, Maud Robert, Cedric Howald, Howard Riezman, Jerome N Feige, Leonidas G Karagounis, Jonathan D Johnston, Emmanouil T Dermitzakis, Frédéric Gachon, Etienne Lefai, Charna Dibner
Circadian regulation of transcriptional processes has a broad impact on cell metabolism. Here, we compared the diurnal transcriptome of human skeletal muscle conducted on serial muscle biopsies in vivo with profiles of human skeletal myotubes synchronized in vitro. More extensive rhythmic transcription was observed in human skeletal muscle compared to in vitro cell culture as a large part of the in vivo mRNA rhythmicity was lost in vitro. siRNA-mediated clock disruption in primary myotubes significantly affected the expression of ~8% of all genes, with impact on glucose homeostasis and lipid metabolism...
April 16, 2018: ELife
https://www.readbyqxmd.com/read/29655396/are-lateral-ankle-injuries-in-children-fractures-or-sprains
#7
Erica Beatty, Maude Deschênes, Patrick Archambault
Clinical questionWhat is the prevalence of Salter-Harris type I distal fibula fractures in children with lateral ankle injuries?Article chosenBoutis K, Plint A, Stimec J, et al. Radiograph-negative lateral ankle injuries in children occult growth plate fracture or sprain? JAMA Pediatr 2016;170(1):e154114.
April 15, 2018: CJEM
https://www.readbyqxmd.com/read/29651275/structural-and-functional-motifs-in-influenza-virus-rnas
#8
REVIEW
Damien Ferhadian, Maud Contrant, Anne Printz-Schweigert, Redmond P Smyth, Jean-Christophe Paillart, Roland Marquet
Influenza A viruses (IAV) are responsible for recurrent influenza epidemics and occasional devastating pandemics in humans and animals. They belong to the Orthomyxoviridae family and their genome consists of eight (-) sense viral RNA (vRNA) segments of different lengths coding for at least 11 viral proteins. A heterotrimeric polymerase complex is bound to the promoter consisting of the 13 5'-terminal and 12 3'-terminal nucleotides of each vRNA, while internal parts of the vRNAs are associated with multiple copies of the viral nucleoprotein (NP), thus forming ribonucleoproteins (vRNP)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29650362/tazemetostat-an-ezh2-inhibitor-in-relapsed-or-refractory-b-cell-non-hodgkin-lymphoma-and-advanced-solid-tumours-a-first-in-human-open-label-phase-1-study
#9
Antoine Italiano, Jean-Charles Soria, Maud Toulmonde, Jean-Marie Michot, Carlo Lucchesi, Andrea Varga, Jean-Michel Coindre, Stephen J Blakemore, Alicia Clawson, Benjamin Suttle, Alice A McDonald, Mark Woodruff, Scott Ribich, Eric Hedrick, Heike Keilhack, Blythe Thomson, Takashi Owa, Robert A Copeland, Peter T C Ho, Vincent Ribrag
BACKGROUND: Activating enhancer of zeste homolog 2 (EZH2) mutations or aberrations of the switch/sucrose non-fermentable (SWI/SNF) complex (eg, mutations or deletions of the subunits INI1 or SMARCA4) can lead to aberrant histone methylation, oncogenic transformation, and a proliferative dependency on EZH2 activity. In this first-in-human study, we aimed to investigate the safety, clinical activity, pharmacokinetics, and pharmacodynamics of tazemetostat, a first-in-class selective inhibitor of EZH2...
April 9, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29643414/switching-between-individual-and-collective-motility-in-b-lymphocytes-is-controlled-by-cell-matrix-adhesion-and-inter-cellular-interactions
#10
Javier Rey-Barroso, Daniel S Calovi, Maud Combe, Yolla German, Mathieu Moreau, Astrid Canivet, Xiaobo Wang, Clément Sire, Guy Theraulaz, Loïc Dupré
Lymphocytes alternate between phases of individual migration across tissues and phases of clustering during activation and function. The range of lymphocyte motility behaviors and the identity of the factors that govern them remain elusive. To explore this point, we here collected unprecedented statistics pertaining to cell displacements, cell:matrix and cell:cell interactions using a model B cell line as well as primary human B lymphocytes. At low cell density, individual B lymphocytes displayed a high heterogeneity in their speed and diffusivity...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29642743/initiative-for-burnout-of-icu-caregivers-feasibility-and-preliminary-results-of-a-psychological-support
#11
Bara Ricou, Fabienne Gigon, Edith Durand-Steiner, Maud Liesenberg, Christine Chemin-Renais, Paolo Merlani, Sylvette Delaloye
BACKGROUND: Intensive care unit (ICU) caregivers are at high risk of burnout and the shortage of this highly specialized personal is a problem. The feasibility and impact of a psychological intervention were never assessed in this special context. METHODS: A randomized controlled single-blind study in an ICU. The first intervention consisted in weekly problem-based sessions led by psychologists with small groups of caregivers using a systemic approach over 3 months...
January 1, 2018: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/29628451/assessing-rehabilitation-eligibility-of-older-patients-an-ethical-analysis-of-the-impact-of-bias
#12
Josephine Najem, Priscilla Lam Wai Shun, Maude Laliberté, Vardit Ravitsky
Hospitalized older patients are more vulnerable to physical or cognitive functional decline. Inpatient rehabilitation programs improve significantly their functional status and may prevent their admission to nursing homes. While inpatient rehabilitation institutions have established admission criteria that can be seen as objective, the risk of bias remains and raises the question of equitable access for more vulnerable populations such as older patients. This paper reviews some established eligibility criteria for inpatient rehabilitation by examining a framework used in Montreal, Québec, Canada for assessing rehabilitation eligibility and by applying this framework to a case study...
2018: Kennedy Institute of Ethics Journal
https://www.readbyqxmd.com/read/29628446/assessment-of-lvef-using-a-new-16-segment-wall-motion-score-in-echocardiography
#13
Real Lebeau, Karim Serri, Maria Di Lorenzo, Claude Sauvé, Van Hoai Viet Le, Vicky Soulières, Malak El-Rayes, Maude Pagé, Chimène Zaïani, Jérôme Garot, Frédéric Poulin
BACKGROUND: Simpson biplane method and 3D by transthoracic echocardiography (TTE), radionuclide angiography (RNA) and cardiac magnetic resonance imaging (CMR) are the most accepted techniques for left ventricular ejection fraction (LVEF) assessment. Wall motion score index (WMSI) by TTE is an accepted complement. However, the conversion from WMSI to LVEF is obtained through a regression equation, which may limit its use. In this retrospective study, we aimed to validate a new method to derive LVEF from the wall motion score in 95 patients...
June 2018: Echo Research and Practice
https://www.readbyqxmd.com/read/29624949/medicinal-plants-used-during-antenatal-care-by-pregnant-women-in-eastern-uganda
#14
Patricia A Nalumansi, Maud Kamatenesi-Mugisha, Godwin Anywar
Plants are commonly used during the antenatal stage in pregnancy to manage different ailments in Africa. In Uganda, both medicinal and food plants are used to handle common pregnancy related conditions. An ethnobotanical survey was conducted in Iganga district, eastern Uganda. Seven traditional birth attendants (TBA) and 46 mothers were interviewed. Data was collected using structured questionnaires and household interviews. The TBAs were identified using snowball sampling. A total of 33 plant species, belonging to 23 families were documented...
December 2017: African Journal of Reproductive Health
https://www.readbyqxmd.com/read/29621244/the-cost-saving-effect-of-centralized-histological-reviews-with-soft-tissue-and-visceral-sarcomas-gist-and-desmoid-tumors-the-experiences-of-the-pathologists-of-the-french-sarcoma-group
#15
Lionel Perrier, Pauline Rascle, Magali Morelle, Maud Toulmonde, Dominique Ranchere Vince, Axel Le Cesne, Philippe Terrier, Agnès Neuville, Pierre Meeus, Fadila Farsi, Françoise Ducimetière, Jean-Yves Blay, Isabelle Ray Coquard, Jean-Michel Coindre
OBJECTIVE: This study examined the types of discordance occurring in the diagnosis of soft tissue and visceral sarcomas, gastrointestinal stromal tumors (GIST), and desmoid tumors, as well as the economic impact of diagnostic discrepancies. METHODS: We carried out a retrospective, multicenter analysis using prospectively implemented databases performed on a cohort of patients within the French RRePS network in 2010. Diagnoses were deemed to be discordant based on the 2013 World Health Organization (WHO) classification...
2018: PloS One
https://www.readbyqxmd.com/read/29620088/persistent-focal-enhancement-of-the-cisternal-segment-of-oculomotor-nerve-in-ophthalmoplegic-migraine
#16
Ihtesham A Qureshi, Gustavo J Rodriguez, Salvador Cruz-Flores, Alberto Maud
No abstract text is available yet for this article.
October 2017: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29618564/postnatal-zika-virus-infection-is-associated-with-persistent-abnormalities-in-brain-structure-function-and-behavior-in-infant-macaques
#17
Maud Mavigner, Jessica Raper, Zsofia Kovacs-Balint, Sanjeev Gumber, Justin T O'Neal, Siddhartha K Bhaumik, Xiaodong Zhang, Jakob Habib, Cameron Mattingly, Circe E McDonald, Victoria Avanzato, Mark W Burke, Diogo M Magnani, Varian K Bailey, David I Watkins, Thomas H Vanderford, Damien Fair, Eric Earl, Eric Feczko, Martin Styner, Sherrie M Jean, Joyce K Cohen, Guido Silvestri, R Paul Johnson, David H O'Connor, Jens Wrammert, Mehul S Suthar, Mar M Sanchez, Maria C Alvarado, Ann Chahroudi
The Zika virus (ZIKV) epidemic is associated with fetal brain lesions and other serious birth defects classified as congenital ZIKV syndrome. Postnatal ZIKV infection in infants and children has been reported; however, data on brain anatomy, function, and behavioral outcomes following infection are absent. We show that postnatal ZIKV infection of infant rhesus macaques (RMs) results in persistent structural and functional alterations of the central nervous system compared to age-matched controls. We demonstrate ZIKV lymphoid tropism and neurotropism in infant RMs and histopathologic abnormalities in the peripheral and central nervous systems including inflammatory infiltrates, astrogliosis, and Wallerian degeneration...
April 4, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29618018/patterns-of-plant-and-animal-protein-intake-are-strongly-associated-with-cardiovascular-mortality-the-adventist-health-study-2-cohort
#18
Marion Tharrey, François Mariotti, Andrew Mashchak, Pierre Barbillon, Maud Delattre, Gary E Fraser
Background: Current evidence suggests that plant and animal proteins are intimately associated with specific large nutrient clusters that may explain part of their complex relation with cardiovascular health. We aimed at evaluating the association between specific patterns of protein intake with cardiovascular mortality. Methods: We selected 81 337 men and women from the Adventist Health Study-2. Diet was assessed between 2002 and 2007, by using a validated food frequency questionnaire...
April 2, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29615761/proteolysis-inhibition-by-hibernating-bear-serum-leads-to-increased-protein-content-in-human-muscle-cells
#19
Stéphanie Chanon, Blandine Chazarin, Benoit Toubhans, Christine Durand, Isabelle Chery, Maud Robert, Aurélie Vieille-Marchiset, Jon E Swenson, Andreas Zedrosser, Alina L Evans, Sven Brunberg, Jon M Arnemo, Guillemette Gauquelin-Koch, Kenneth B Storey, Chantal Simon, Stéphane Blanc, Fabrice Bertile, Etienne Lefai
Muscle atrophy is one of the main characteristics of human ageing and physical inactivity, with resulting adverse health outcomes. To date, there are still no efficient therapeutic strategies for its prevention and/or treatment. However, during hibernation, bears exhibit a unique ability for preserving muscle in conditions where muscle atrophy would be expected in humans. Therefore, our objective was to determine whether there are components of bear serum which can control protein balance in human muscles. In this study, we exposed cultured human differentiated muscle cells to bear serum collected during winter and summer periods, and measured the impact on cell protein content and turnover...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29615506/coexistence-of-multiple-endemic-and-pandemic-lineages-of-the-rice-blast-pathogen
#20
Pierre Gladieux, Sébastien Ravel, Adrien Rieux, Sandrine Cros-Arteil, Henri Adreit, Joëlle Milazzo, Maud Thierry, Elisabeth Fournier, Ryohei Terauchi, Didier Tharreau
The rice blast fungus Magnaporthe oryzae (syn., Pyricularia oryzae ) is both a threat to global food security and a model for plant pathology. Molecular pathologists need an accurate understanding of the origins and line of descent of M. oryzae populations in order to identify the genetic and functional bases of pathogen adaptation and to guide the development of more effective control strategies. We used a whole-genome sequence analysis of samples from different times and places to infer details about the genetic makeup of M...
April 3, 2018: MBio
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