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https://www.readbyqxmd.com/read/28437788/high-prevalence-of-polycystic-ovary-syndrome-in-type-1-diabetes-mellitus-adolescents-is-there-a-difference-depending-on-the-nih-and-rotterdam-criteria
#1
Kanetee Busiah, Ana Colmenares, Maud Bidet, Nadia Tubiana-Rufi, Claire Levy-Marchal, Christine Delcroix, Paul Jacquin, Delphine Martin, Lila Benadjaoud, Evelyne Jacqz-Aigrain, Kathleen Laborde, Jean-Jacques Robert, Dinane Samara-Boustani, Michel Polak
BACKGROUND: Polycystic ovary syndrome (PCOS) is more frequently observed in type 1 diabetes mellitus (T1DM) adult women than in nondiabetic women. No such prevalence has yet been studied in adolescent girls with T1DM. AIM: The aim of this study was to evaluate the prevalence of PCOS in adolescent girls with T1DM and to determine the clinical and hormonal features associated with the disorder. METHODS: A cross-sectional study of 53 adolescent girls (gynecological age >2 years) referred for routine evaluation for T1DM was conducted...
April 24, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28430808/quantification-of-hypoxia-related-gene-expression-as-a-potential-approach-for-clinical-outcome-prediction-in-breast-cancer
#2
Abderrahim El Guerrab, Anne Cayre, Fabrice Kwiatkowski, Maud Privat, Jean-Marc Rossignol, Fabrice Rossignol, Frédérique Penault-Llorca, Yves-Jean Bignon
Breast cancers are solid tumors frequently characterized by regions with low oxygen concentrations. Cellular adaptations to hypoxia are mainly determined by "hypoxia inducible factors" that mediate transcriptional modifications involved in drug resistance and tumor progression leading to metastasis and relapse occurrence. In this study, we investigated the prognostic value of hypoxia-related gene expression in breast cancer. A systematic review was conducted to select a set of 45 genes involved in hypoxia signaling pathways and breast tumor progression...
2017: PloS One
https://www.readbyqxmd.com/read/28430558/lower-esophageal-sphincter-augmentation-for-gastroesophageal-reflux-disease-the-safety-of-a-modern-implant
#3
C Daniel Smith, Robert A Ganz, John C Lipham, Reginald C Bell, David W Rattner
INTRODUCTION: Use of the magnetic sphincter augmentation device (MSAD) for gastroesophageal reflux disease (GERD) is increasing. As this innovative treatment for GERD gains widespread use and adoption, an assessment of its safety since U.S. market introduction is presented. METHODS: Events were collected from the Manufacturer and User Facility Device Experience (MAUDE) database, which reports events submitted to the Food and Drug Administration (FDA) of suspected device-associated deaths, serious injuries, and malfunctions...
April 21, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28427329/cross-disorder-comparative-analysis-of-comorbid-conditions-reveals-novel-autism-candidate-genes
#4
Leticia Diaz-Beltran, Francisco J Esteban, Maya Varma, Alp Ortuzk, Maude David, Dennis P Wall
BACKGROUND: Numerous studies have highlighted the elevated degree of comorbidity associated with autism spectrum disorder (ASD). These comorbid conditions may add further impairments to individuals with autism and are substantially more prevalent compared to neurotypical populations. These high rates of comorbidity are not surprising taking into account the overlap of symptoms that ASD shares with other pathologies. From a research perspective, this suggests common molecular mechanisms involved in these conditions...
April 20, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28424983/the-effect-of-gastrostomy-placement-on-gastric-function-in-children-a-prospective-cohort-study
#5
Josephine Franken, Femke A Mauritz, Rebecca K Stellato, David C Van der Zee, Maud Y A Van Herwaarden-Lindeboom
BACKGROUND: A gastrostomy placement is frequently performed in pediatric patients who require long-term enteral tube feeding. Unfortunately, postoperative complications such as leakage, feeding intolerance, and gastroesophageal reflux frequently occur. These complications may be due to postoperative gastric dysmotility. Our aim was to evaluate the effect of gastrostomy placement on gastric emptying in children. METHODS: A prospective study was performed including 50 children undergoing laparoscopic gastrostomy...
April 19, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28419631/tgpl2-a-patatin-like-phospholipase-domain-containing-protein-is-involved-in-the-maintenance-of-apicoplast-lipids-homeostasis-in-toxoplasma
#6
Maude F Lévêque, Laurence Berry, Yoshiki Yamaryo-Botté, Hoa Mai Nguyen, Marine Galera, Cyrille Y Botté, Sébastien Besteiro
Patatin-like phospholipases are involved in numerous cellular functions, including lipid metabolism and membranes remodeling. The patatin-like catalytic domain, whose phospholipase activity relies on a serine-aspartate dyad and an anion binding box, is widely spread among prokaryotes and eukaryotes. We describe TgPL2, a novel patatin-like phospholipase domain-containing protein from the parasitic protist Toxoplasma gondii. TgPL2 is a large protein, in which the key motifs for enzymatic activity are conserved in the patatin-like domain...
April 17, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28417207/impact-of-food-processing-on-rye-product-properties-and-their-in-vitro-digestion
#7
Daniel P Johansson, José L Vázquez Gutiérrez, Rikard Landberg, Marie Alminger, Maud Langton
PURPOSE: Rye products have been reported to elicit postprandial insulin and glucose responses which may be beneficial for prevention of type-2 diabetes. However, mechanisms underlying variations in responses related to processing techniques are not fully understood. METHODS: Five differently processed rye products (sourdough-fermented bread, fermented and unfermented crispbread, extrusion-cooked rye, and porridge) and refined wheat bread were characterised. Two in vitro methods, a dynamic method simulating digestion in the stomach and small intestine and a static method, simulating conditions in the stomach were used to determine viscosity development, structural changes and release of glucose during digestion...
April 17, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28416466/risk-of-atrioesophageal-fistula-formation-with-contact-force-sensing-catheters
#8
Eric Black-Maier, Sean D Pokorney, Adam S Barnett, Emily P Zeitler, Albert Y Sun, Kevin P Jackson, Tristram D Bahnson, James P Daubert, Jonathan P Piccini
BACKGROUND: Atrioesophageal fistula formation is a rare but life-threatening complication of AF ablation. Contact force (CF) sensing catheters improve procedural effectiveness. However, the impact of the implementation of CF-sensing technology on risk of atrioesophageal fistula formation has not been explored. OBJECTIVE: To determine the association between the use of CF sensing catheters and atrioesophageal fistula development METHODS: We searched the Manufacturer and User Facility Device Experience (MAUDE) database for adverse event reports involving FDA approved ablation catheters...
April 14, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28413855/frequency-of-pacemaker-malfunction-associated-with-monopolar-electrosurgery-during-pulse-generator-replacement-or-upgrade-surgery
#9
Yun Lin, Daniel P Melby, Balaji Krishnan, Selcuk Adabag, Venkatakrishna Tholakanahalli, Jian-Ming Li
PURPOSE: The aim of this study is to investigate the frequency of electrosurgery-related pacemaker malfunction. METHODS: A retrospective study was conducted to investigate electrosurgery-related pacemaker malfunction in consecutive patients undergoing pulse generator (PG) replacement or upgrade from two large hospitals in Minneapolis, MN between January 2011 and January 2014. The occurrence of this pacemaker malfunction was then studied by using MAUDE database for all four major device vendors...
April 17, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28407949/direct-technique-for-monitoring-lipid-oxidation-in-water-in-oil-emulsions-based-on-micro-calorimetry
#10
Wafa Dridi, Jean Toutain, Alain Sommier, Wafa Essafi, Fernando Leal-Calderon, Maud Cansell
An experimental device based on the measurement of the heat flux dissipated during chemical reactions, previously validated for monitoring lipid oxidation in plant oils, was extended to follow lipid oxidation in water-in-oil emulsions. Firstly, validation of the approach was performed by correlating conjugated diene concentrations measured by spectrophotometry and the heat flux dissipated by oxidation reactions and measured directly in water-in-oil emulsions, in isothermal conditions at 60°C. Secondly, several emulsions based on plant oils differing in their n-3 fatty acid content were compared...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28406913/no-age-effect-in-the-prevalence-and-clinical-significance-of-ultra-high-risk-symptoms-and-criteria-for-psychosis-in-22q11-deletion-syndrome-confirmation-of-the-genetically-driven-risk-for-psychosis
#11
Marco Armando, Maude Schneider, Maria Pontillo, Stefano Vicari, Martin Debbané, Frauke Schultze-Lutter, Stephan Eliez
BACKGROUND: The 22q11.2 deletion syndrome (22q11DS) is one of the highest known risk factors for schizophrenia. Thus, the detection of 22q11DS patients at particularly high risk of psychosis is important, yet studies on the clinical significance of the widely used ultra-high risk (UHR) criteria in 22q11DS are inconclusive. Since age was reported to moderate clinical significance of UHR symptoms in community samples, we explored whether age at presentation of UHR symptoms and criteria may explain part of this heterogeneity...
2017: PloS One
https://www.readbyqxmd.com/read/28405607/chemoattractant-mediated-leukocyte-trafficking-enables-hiv-dissemination-from-the-genital-mucosa
#12
Maud Deruaz, Thomas T Murooka, Sophina Ji, Marc A Gavin, Vladimir D Vrbanac, Judy Lieberman, Andrew M Tager, Thorsten R Mempel, Andrew D Luster
HIV vaginal transmission accounts for the majority of newly acquired heterosexual infections. However, the mechanism by which HIV spreads from the initial site of viral entry at the mucosal surface of the female genital tract to establish a systemic infection of lymphoid and peripheral tissues is not known. Once the virus exits the mucosa it rapidly spreads to all tissues, leading to CD4(+) T cell depletion and the establishment of a viral reservoir that cannot be eliminated with current treatments. Understanding the molecular and cellular requirements for viral dissemination from the genital tract is therefore of great importance, as it could reveal new strategies to lengthen the window of opportunity to target the virus at its entry site in the mucosa where it is the most vulnerable and thus prevent systemic infection...
April 6, 2017: JCI Insight
https://www.readbyqxmd.com/read/28404773/not-equal-in-the-face-of-habitat-change-closely-related-fishes-differ-in-their-ability-to-use-predation-related-information-in-degraded-coral
#13
Maud C O Ferrari, Mark I McCormick, Bridie J M Allan, Douglas P Chivers
Coral reefs are biodiversity hotpots that are under significant threat due to the degradation and death of hard corals. When obligate coral-dwelling species die, the remaining species must either move or adjust to the altered conditions. Our goal was to investigate the effect of coral degradation on the ability of coral reef fishes to assess their risk of predation using alarm cues from injured conspecifics. Here, we tested the ability of six closely related species of juvenile damselfish (Pomacentridae) to respond to risk cues in both live coral or dead-degraded coral environments...
April 12, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28403911/predomos-study-impact-of-a-social-intervention-program-for-socially-isolated-elderly-cancer-patients-study-protocol-for-a-randomized-controlled-trial
#14
Elodie Crétel-Durand, Emilie Nouguerède, Hervé Le Caer, Frédérique Rousseau, Frédérique Retornaz, Olivier Guillem, Anne-Laure Couderc, Laurent Greillier, Emmanuelle Norguet, Maud Cécile, Rabia Boulahssass, Francoise Le Caer, Sandrine Tournier, Chantal Butaud, Pierre Guillet, Sophie Nahon, Laure Poudens, Sylvie Kirscher, Sandrine Loubière, Nadine Diaz, Jean Dhorne, Pascal Auquier, Karine Baumstarck
BACKGROUND: Cancer incidence and social isolation increase along with advanced age, and social isolation potentiates the relative risk of death by cancer. Once spotted, social isolation can be averted with the intervention of a multidisciplinary team. Techniques of automation and remote assistance have already demonstrated their positive impact on falls prevention and quality of life (QoL), though little is known about their impact on socially isolated elderly patients supported for cancer...
April 12, 2017: Trials
https://www.readbyqxmd.com/read/28403522/structure-activity-relationship-studies-spr-affinity-characterization-and-conformational-analysisof-peptides-mimicking-the-hnk-1-carbohydrate-epitope
#15
Paolo Rovero, Matthaia Ieronymaki, Francesca Nuti, Diego Brancaccio, Giada Rossi, Feliciana Real-Fernández, Yihong Cao, Olivier Monasson, Maud Larregola, Elisa Peroni, Jacques Uziel, Giuseppina Sabatino, Ettore Novellino, Alfonso Carotenuto, Anna Maria Papini
The design of molecules mimicking biologically relevant glycans is a significant goal for understanding important biological processesand may lead to new therapeutic and diagnostic agents. We focused our attention on the trisaccharide human natural killer cell-1 (HNK-1), considered the antigenic determinant ofmyelin-associated glycoprotein and the target of clinically relevant auto-antibodies in autoimmune neurological disorders such as IgM monoclonal gammopathy and demyelinating polyneuropathy.We describe a structure-activity relationship study based on surface plasmon resonance binding affinities aiming at the optimization of a peptide mimicking the HNK-1 minimal epitope...
April 12, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28402917/towards-the-integration-of-orbital-space-use-in-life-cycle-impact-assessment
#16
Thibaut Maury, Philippe Loubet, Jonathan Ouziel, Maud Saint-Amand, Ludovic Dariol, Guido Sonnemann
A rising sustainability concern is occurring in the space sector: 29,000 human-made objects, larger than 10cm are orbiting the Earth but only 6% are operational spacecrafts. Today, space debris is today a significant and constant danger to all space missions. Consequently, it becomes compelled to design new space missions considering End-of-Life requirements in order to ensure the sustainable use of space orbits. Furthermore, Life Cycle Assessment (LCA) has been identified by the European Space Agency as an adequate tool to measure the environmental impact of spacecraft missions...
April 9, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28402338/insulin-deprivation-induces-pp2a-inhibition-and-tau-hyperphosphorylation-in-htau-mice-a-model-of-alzheimer-s-disease-like-tau-pathology
#17
Maud Gratuze, Jacinthe Julien, Franck R Petry, Françoise Morin, Emmanuel Planel
Abnormally hyperphosphorylated tau aggregated as intraneuronal neurofibrillary tangles is one of the two neuropathological hallmarks of Alzheimer's disease (AD). The majority of AD cases are sporadic with numerous environmental, biological and genetic risks factors. Interestingly, insulin dysfunction and hyperglycaemia are both risk factors for sporadic AD. However, how hyperglycaemia and insulin dysfunction affect tau pathology, is not well understood. In this study, we examined the effects of insulin deficiency on tau pathology in transgenic hTau mice by injecting different doses of streptozotocin (STZ), a toxin that destroys insulin-producing cells in the pancreas...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28398960/prevalence-and-risk-factors-of-non-alcoholic-fatty-liver-disease-in-hiv-monoinfection-a-systematic-review-and-meta-analysis
#18
James B Maurice, Amee Patel, Alasdair J Scott, Krish Patel, Mark Thursz, Maud Lemoine
OBJECTIVE: to identify the prevalence and risk factors of NAFLD, NASH and fibrosis in HIV-monoinfected patients. DESIGN: Systematic review and meta-analysis. METHODS: We searched Medline and Embase and included studies that enrolled HIV-monoinfected patients with NAFLD defined by imaging and/or liver histology. Data on prevalence and risk factors for NAFLD, NASH and fibrosis were collected for meta-analysis using random effects models. RESULTS: Ten studies were included from USA (n = 4), Canada (n = 1), France (n = 2), Italy (n = 1), Japan (n = 1) and China (n = 1)...
April 10, 2017: AIDS
https://www.readbyqxmd.com/read/28396520/cytosine-modifications-modulate-the-chromatin-architecture-of-transcriptional-enhancers
#19
Elise A Mahé, Thierry Madigou, Aurélien A Sérandour, Maud Bizot, Stéphane Avner, Frédéric Chalmel, Gaëlle Palierne, Raphaël Métivier, Gilles Salbert
Epigenetic mechanisms are believed to play key roles in the establishment of cell-specific transcription programs. Accordingly, the modified bases 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) have been observed in DNA of genomic regulatory regions such as enhancers, and oxidation of 5mC into 5hmC by Ten Eleven Translocation (TET) proteins correlates with enhancer activation. However, the functional relationship between cytosine modifications and the chromatin architecture of enhancers remains elusive...
April 10, 2017: Genome Research
https://www.readbyqxmd.com/read/28393519/effect-of-bread-crumb-and-crust-structure-on-the-in-vivo-release-of-volatiles-and-the-dynamics-of-aroma-perception
#20
Solenne Jourdren, Marine Masson, Anne Saint-Eve, Maud Panouillé, David Blumenthal, Pascal Lejeune, Isabelle Déléris, Isabelle Souchon
This study examined the effects of bread crumb and crust structure on volatile release and aroma perception during oral processing. French baguettes with different crumb structures were procured from a supermarket or local bakeries (n = 6) or produced in the laboratory via par baking (n = 3). Eight study participants consumed crumb-only and crumb-and-crust samples, and the resulting volatile release was measured in vivo using proton transfer reaction-mass spectrometry. A statistical model was then used to examine the contributions of volatile compounds to target ion production (i...
April 14, 2017: Journal of Agricultural and Food Chemistry
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