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https://www.readbyqxmd.com/read/28632780/metformin-intake-associates-with-better-cognitive-function-in-patients-with-huntington-s-disease
#1
David Hervás, Victoria Fornés-Ferrer, Ana Pilar Gómez-Escribano, María Dolores Sequedo, Carmen Peiró, José María Millán, Rafael P Vázquez-Manrique
Huntington's disease (HD) is an inherited, dominant neurodegenerative disorder caused by an abnormal expansion of CAG triplets in the huntingtin gene (htt). Despite extensive efforts to modify the progression of HD thus far only symptomatic treatment is available. Recent work suggests that treating invertebrate and mice HD models with metformin, a well-known AMPK activator which is used worldwide to treat type 2-diabetes, reduces mutant huntingtin from cells and alleviates many of the phenotypes associated to HD...
2017: PloS One
https://www.readbyqxmd.com/read/28623613/assessment-of-metabolic-flexibility-by-means-of-measuring-blood-lactate-fat-and-carbohydrate-oxidation-responses-to-exercise-in-professional-endurance-athletes-and-less-fit-individuals
#2
Iñigo San-Millán, George A Brooks
BACKGROUND: Increased muscle mitochondrial mass is characteristic of elite professional endurance athletes (PAs), whereas increased blood lactate levels (lactatemia) at the same absolute submaximal exercise intensities and decreased mitochondrial oxidative capacity are characteristics of individuals with low aerobic power. In contrast to PAs, patients with metabolic syndrome (MtS) are characterized by a decreased capacity to oxidize lipids and by early transition from fat to carbohydrate oxidation (FATox/CHOox), as well as elevated blood lactate concentration [La(-)] as exercise power output (PO) increases, a condition termed 'metabolic inflexibility'...
June 16, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28623340/adenovirus-mediated-suppression-of-hypothalamic-glucokinase-affects-feeding-behavior
#3
Romina María Uranga, Carola Millán, María José Barahona, Antonia Recabal, Magdiel Salgado, Fernando Martinez, Patricio Ordenes, Roberto Elizondo-Vega, Fernando Sepúlveda, Elena Uribe, María de Los Ángeles García-Robles
Glucokinase (GK), the hexokinase involved in glucosensing in pancreatic β-cells, is also expressed in arcuate nucleus (AN) neurons and hypothalamic tanycytes, the cells that surround the basal third ventricle (3V). Several lines of evidence suggest that tanycytes may be involved in the regulation of energy homeostasis. Tanycytes have extended cell processes that contact the feeding-regulating neurons in the AN, particularly, agouti-related protein (AgRP), neuropeptide Y (NPY), cocaine- and amphetamine-regulated transcript (CART) and proopiomelanocortin (POMC) neurons...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28620214/phylogenomic-insight-into-salinispora-bacteria-actinobacteria-species-designations
#4
Natalie Millán-Aguiñaga, Krystle L Chavarria, Juan A Ugalde, Anne-Catrin Letzel, Greg W Rouse, Paul R Jensen
Bacteria represent the most genetically diverse kingdom of life. While great progress has been made in describing this diversity, it remains difficult to identify the phylogenetic and ecological characteristics that delineate groups of bacteria that possess species-like properties. One major challenge associated with species delineations is that not all shared genes have the same evolutionary history, and thus the choice of loci can have a major impact on phylogenetic reconstruction. Sequencing the genomes of large numbers of closely related strains provides new opportunities to distinguish ancestral from acquired alleles and assess the effects of recombination on phylogenetic inference...
June 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619627/composition-spatial-distribution-and-sources-of-macro-marine-litter-on-the-gulf-of-alicante-seafloor-spanish-mediterranean
#5
Santiago García-Rivera, Jose Luis Sánchez Lizaso, Jose María Bellido Millán
The composition, spatial distribution and source of marine litter in the Spanish Southeast Mediterranean were assessed. The data proceed from a marine litter retention programme implemented by commercial trawlers and were analysed by GIS. By weight, 75.9% was plastic, metal and glass. Glass and plastics were mainly found close to the coast. A high concentration of metal was observed in some isolated zones of both open and coastal waters. Fishing activity was the source of 29.16% of the macro-marine litter, almost 68...
June 12, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28619142/drivers-of-bartonella-infection-in-micromammals-and-their-fleas-in-a-mediterranean-peri-urban-area
#6
Aitor Cevidanes, Laura Altet, Andrea D Chirife, Tatiana Proboste, Javier Millán
People living at the human/wildlife interface are at risk of becoming infected with Bartonella for which micromammals act as reservoir. We aimed to determine the factors related to the prevalence of Bartonella and its haplotype diversity in micromammals and in their fleas in a Mediterranean peri-urban environment. We analyzed 511 micromammals, chiefly 407 wood mice (Apodemus sylvaticus), captured into Barcelona metropolitan area (Spain) in spring and autumn from 2011 to 2013 in two natural and two adjacent residential areas, their fleas (grouped in 218 monospecific pools) and 29 fetuses from six Bartonella-positive female wood mice...
May 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28615850/prevalence-of-giardiaduodenalis-among-children-from-a-central-region-of-cuba-molecular-characterization-and-associated-risk-factors
#7
Luis Jerez Puebla, Fidel A Núñez, Alexey Brito García, Lázara Rojas Rivero, Irais Atencio Millán, Raúl Cordoví Prado
Giardia duodenalis is one of the most frequent intestinal parasitic infections in children worldwide. To date, eight main assemblages of G. duodenalis have been described, but only A and B genetic groups are known to infect humans. A cross-sectional study was conducted to determine the prevalence and risk factors of Giardia duodenalis infection in 417 preschool children from the Fomento municipality in the central region of Cuba between January and June 2013. The overall prevalence of Giardia infection was 10...
June 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28612852/the-bouncing-threshold-in-silica-nanograin-collisions
#8
Maureen L Nietiadi, Philipp Umstätter, Tiffany Tjong, Yudi Rosandi, Emmanuel N Millán, Eduardo M Bringa, Herbert M Urbassek
Using molecular dynamics simulations, we study collisions between amorphous silica nanoparticles. Our silica model contains uncontaminated surfaces, that is, the effect of surface hydroxylation or of adsorbed water layers is excluded. For central collisions, we characterize the boundary between sticking and bouncing collisions as a function of impact velocity and particle size and quantify the coefficient of restitution. We show that the traditional Johnson-Kendall-Roberts (JKR) model provides a valid description of the ingoing trajectory of two grains up to the moment of maximum compression...
June 14, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28611442/competing-factors-link-to-bone-health-in-polycystic-ovary-syndrome-chronic-low-grade-inflammation-takes-a-toll
#9
Shirin Kalyan, Millan S Patel, Elaine Kingwell, Hélène C F Côté, Danmei Liu, Jerilynn C Prior
Chronic inflammation predisposes to poor bone health. Women with polycystic ovary syndrome (PCOS) experience androgen excess, ovulatory disturbances, insulin resistance, abdominal adiposity and chronic inflammation. Our objective was to investigate the relationships among bone health parameters, chronic subclinical inflammation and anthropometric measures in premenopausal women with and without PCOS. In 61 premenopausal women, 22 women with PCOS and 39 controls, we assessed bone parameters (total hip bone mineral density [BMD] by dual-energy X-ray absorptiometry and radius strength-strain index [SSI] by peripheral quantitative computed tomography), inflammation (C-reactive protein/albumin), oxidative stress (leukocyte telomere length, urinary 8-hydroxydeoxyguanosine); hemoglobin A1c; anthropometric measures (body mass index, waist-to-height ratio, cross-sectional muscle area)...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28602752/analysis-of-complications-of-prone-position-in-acute-respiratory-distress-syndrome-quality-standard-incidence-and-related-factors
#10
E Jové Ponseti, A Villarrasa Millán, D Ortiz Chinchilla
INTRODUCTION: The monitoring system based on standards of quality allows clinicians to evaluate and improve the patient's care. According to the quality indicators recommended by Sociedad Española de Medicina Intensiva Crítica y Unidades Coronarias, and due to the importance of prone position (PP) as a treatment in patients with acute respiratory distress syndrome, it is fundamental to keep accurate record of serious adverse events occurring during the prone position procedure and its posterior analysis...
June 8, 2017: Enfermería Intensiva
https://www.readbyqxmd.com/read/28601190/psychological-and-physiological-human-responses-to-simulated-and-real-environments-a-comparison-between-photographs-360%C3%A2-panoramas-and-virtual-reality
#11
Juan Luis Higuera-Trujillo, Juan López-Tarruella Maldonado, Carmen Llinares Millán
Psychological research into human factors frequently uses simulations to study the relationship between human behaviour and the environment. Their validity depends on their similarity with the physical environments. This paper aims to validate three environmental-simulation display formats: photographs, 360° panoramas, and virtual reality. To do this we compared the psychological and physiological responses evoked by simulated environments set-ups to those from a physical environment setup; we also assessed the users' sense of presence...
June 7, 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28592560/ectopic-calcification-in-pseudoxanthoma-elasticum-responds-to-inhibition-of-tissue-nonspecific-alkaline-phosphatase
#12
Shira G Ziegler, Carlos R Ferreira, Elena Gallo MacFarlane, Ryan C Riddle, Ryan E Tomlinson, Emily Y Chew, Ludovic Martin, Chen-Ting Ma, Eduard Sergienko, Anthony B Pinkerton, José Luis Millán, William A Gahl, Harry C Dietz
Biallelic mutations in ABCC6 cause pseudoxanthoma elasticum (PXE), a disease characterized by calcification in the skin, eyes, and blood vessels. The function of ATP-binding cassette C6 (ABCC6) and the pathogenesis of PXE remain unclear. We used mouse models and patient fibroblasts to demonstrate genetic interaction and shared biochemical and cellular mechanisms underlying ectopic calcification in PXE and related disorders caused by defined perturbations in extracellular adenosine 5'-triphosphate catabolism...
June 7, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28583862/recovery-of-glomerular-morphology-in-the-olfactory-bulb-of-young-mice-after-disruption-caused-by-continuous-odorant-exposure
#13
Fernanda Monjaraz-Fuentes, Diana Millán-Adalco, Marcela Palomero-Rivero, Robyn Hudson, René Drucker-Colín
Olfactory glomeruli are the first synaptic site of the olfactory system and are formed by the convergence of axons of the same type of sensory neurons onto the olfactory bulbs of the brain. Although the anatomical organization of glomeruli is conserved across species, their particular role in olfactory processing remains uncertain. We studied the composition and maintenance of glomeruli by means of a genetic model, mI7-IRES-tauGFP knock-in young mice, where the cytoskeleton of sensory neurons expressing the mI7 olfactory receptor is tagged with green fluorescent protein...
June 2, 2017: Brain Research
https://www.readbyqxmd.com/read/28583399/acute-aortic-arch-perforation-during-transcatheter-aortic-valve-replacement-in-bicuspid-aortic-stenosis-and-a-gothic-aortic-arch
#14
Oscar Millan-Iturbe, Fadi J Sawaya, Gintautas Bieliauskas, Danny H F Chow, Ole De Backer, Lars Søndergaard
Transcatheter aortic valve replacement (TAVR) has evolved from a novel technology to an established therapy for high/intermediate-risk patients with severe symptomatic aortic stenosis (AS). Although TAVR is used to treat bicuspid severe AS, the large randomized trials typically excluded bicuspid AS because of its unique anatomic features. This case report describes an acute aortic perforation during delivery of a transcatheter heart valve to treat a severe bicuspid AS with a "gothic aortic arch"; more careful evaluation of the preprocedural multislice computed tomographic scan would have unveiled a sharply angulated aortic arch...
March 28, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28582539/more-than-meets-the-eye-igg4-related-disease-presenting-as-isolated-interstitial-lung-disease
#15
Aprajita Jagpal, David R Crowe, Joao A de Andrade, Maria Del Pilar Acosta Lara, Iris Navarro-Millan
No abstract text is available yet for this article.
June 3, 2017: Rheumatology
https://www.readbyqxmd.com/read/28580465/effect-of-mdp-containing-silane-and-adhesive-used-alone-or-in-combination-on-the-long-term-bond-strength-and-chemical-interaction-with-lithium-disilicate-ceramics
#16
Andres Millan Cardenas, Fabiana Siqueira, Viviane Hass, Pâmela Malaquias, Mario Felipe Gutierrez, Alessandra Reis, Jorge Perdigão, Alessandro D Loguercio
PURPOSE: To evaluate the effect of a silane and an adhesive containing MDP, used alone or combined in the same solution, on the microshear bond strength (μSBS) to lithium disilicate ceramics immediately and after 1-year water storage, and compare the bond strength results with the Raman spectra of the treated lithium disilicate surfaces. MATERIALS AND METHODS: A total of 30 CAD/CAM blocks of lithium disilicate (LD; IPS e.max CAD) were cut into four square sections (6 x 6 x 6 mm; n = 60 per group) and processed as recommended by the manufacturer...
June 2, 2017: Journal of Adhesive Dentistry
https://www.readbyqxmd.com/read/28576848/identification-of-fc-gamma-receptor-glycoforms-that-produce-differential-binding-kinetics-for-rituximab
#17
Jerrard M Hayes, Asa Frostell, Robert Karlsson, Steffen Müller, Silvia Millan-Martin, Martin Pauers, Franziska Reuss, Eoin Cosgrave, Cecilia Anneren, Gavin P Davey, Pauline M Rudd
Fc gamma receptors (FcyR) bind the Fc region of antibodies and therefore play a prominent role in antibody-dependent cell-based immune responses such as ADCC, CDC and ADCP. The immune effector cell activity is directly linked to a productive molecular engagement of FcyRs where both the protein and glycan moiety of antibody and receptor can affect the interaction and in the present study we focus on the role of the FcyR glycans in this interaction. We provide a complete description of the glycan composition of Chinese hamster ovary (CHO) expressed human Fcy receptors RI (CD64), RIIa Arg131/His131 (CD32a), RIIb (CD32b) and RIIIa Phe158/Val158 (CD16a) and analyze the role of the glycans in the binding mechanism with IgG...
June 2, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28574190/flow-aligned-single-shot-fiber-diffraction-using-a-femtosecond-x-ray-free-electron-laser
#18
David Popp, N Duane Loh, Habiba Zorgati, Umesh Ghoshdastider, Lu Ting Liow, Magdalena I Ivanova, Mårten Larsson, Daniel P DePonte, Richard Bean, Kenneth R Beyerlein, Cornelius Gati, Dominik Oberthuer, David Arnlund, Gisela Brändén, Peter Berntsen, Duilio Cascio, Leonard M G Chavas, Joe P J Chen, Ke Ding, Holger Fleckenstein, Lars Gumprecht, Rajiv Harimoorthy, Estelle Mossou, Michael R Sawaya, Aaron S Brewster, Johan Hattne, Nicholas K Sauter, Marvin Seibert, Carolin Seuring, Francesco Stellato, Thomas Tilp, David S Eisenberg, Marc Messerschmidt, Garth J Williams, Jason E Koglin, Lee Makowski, Rick P Millane, Trevor Forsyth, Sébastien Boutet, Thomas A White, Anton Barty, Henry Chapman, Swaine L Chen, Mengning Liang, Richard Neutze, Robert C Robinson
A major goal for X-ray free-electron laser (XFEL) based science is to elucidate structures of biological molecules without the need for crystals. Filament systems may provide some of the first single macromolecular structures elucidated by XFEL radiation, since they contain one-dimensional translational symmetry and thereby occupy the diffraction intensity region between the extremes of crystals and single molecules. Here, we demonstrate flow alignment of as few as 100 filaments (Escherichia coli pili, F-actin, and amyloid fibrils), which when intersected by femtosecond X-ray pulses result in diffraction patterns similar to those obtained from classical fiber diffraction studies...
June 2, 2017: Cytoskeleton
https://www.readbyqxmd.com/read/28560880/quantitative-proteomics-analysis-confirmed-oxidative-metabolism-predominates-in-streptomyces-coelicolor-versus-glycolytic-metabolism-in-streptomyces-lividans
#19
Aaron Millan-Oropeza, Céline Henry, Mélisande Blein-Nicolas, Anne Aubert-Frambourg, Fathi Moussa, Jean Bleton, Marie-Jöelle Virolle
Recent physiological studies indicated that S. lividans metabolism was mainly glycolytic, whereas S. coelicolor metabolism was mainly oxidative. To determine whether such metabolic characteristics were correlated with consistent proteomics features, a comparative label-free, shotgun proteomics analysis of these strains was carried out. Among 2024 proteins identified, 360 showed significant differences in abundance between the strains. This study revealed that S. coelicolor catabolized glucose less actively than S...
June 15, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28555616/central-and-peripheral-clocks-are-coupled-by-a-neuropeptide-pathway-in-drosophila
#20
Mareike Selcho, Carola Millán, Angelina Palacios-Muñoz, Franziska Ruf, Lilian Ubillo, Jiangtian Chen, Gregor Bergmann, Chihiro Ito, Valeria Silva, Christian Wegener, John Ewer
Animal circadian clocks consist of central and peripheral pacemakers, which are coordinated to produce daily rhythms in physiology and behaviour. Despite its importance for optimal performance and health, the mechanism of clock coordination is poorly understood. Here we dissect the pathway through which the circadian clock of Drosophila imposes daily rhythmicity to the pattern of adult emergence. Rhythmicity depends on the coupling between the brain clock and a peripheral clock in the prothoracic gland (PG), which produces the steroid hormone, ecdysone...
May 30, 2017: Nature Communications
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