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https://www.readbyqxmd.com/read/29789212/fibrates-in-primary-prevention-of-cardiovascular-disease-comments-on-the-results-of-a-systematic-review-of-the-cochrane-collaboration
#1
Angel Brea, Jesús Millán, Juan F Ascaso, Mariano Blasco, Angel Díaz, Antonio Hernández-Mijares, Teresa Mantilla, Juan C Pedro-Botet, Xavier Pintó
Fibrates are drugs that reduce triglycerides, elevate high-density lipoproteins, as well as decrease small, dense LDL particles. The results of a study have recently been published by the Cochrane Collaboration on fibrates efficacy and safety in the primary prevention of cardiovascular disease. This study includes a systematic review and a meta-analysis of 6 studies (16,135 patients) that evaluated the clinical benefits of fibrates compared to placebo use or other lipid-lowering drugs. This review showed evidence of a protective effect of the fibrates compared with placebo as regards a reduction 16% of a compound objective of death due to cardiovascular disease, non-fatal myocardial infarction, or non-fatal cerebrovascular accident (NNT: 112), and that reduce coronary morbidity and mortality by 21% (NNT: 125)...
May 19, 2018: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/29781985/testing-the-role-of-multicopy-plasmids-in-the-evolution-of-antibiotic-resistance
#2
Jose Antonio Escudero, R Craig MacLean, Alvaro San Millan
Multicopy plasmids are extremely abundant in prokaryotes but their role in bacterial evolution remains poorly understood. We recently showed that the increase in gene copy number per cell provided by multicopy plasmids could accelerate the evolution of plasmid-encoded genes. In this work, we present an experimental system to test the ability of multicopy plasmids to promote gene evolution. Using simple molecular biology methods, we constructed a model system where an antibiotic resistance gene can be inserted into Escherichia coli MG1655, either in the chromosome or on a multicopy plasmid...
May 2, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29774288/molecular-analysis-of-giardia-duodenalis-isolates-from-symptomatic-and-asymptomatic-children-from-la-habana-cuba
#3
Luis Enrique Jerez Puebla, Fidel A Núñez, Lissette Pérez Santos, Lázara Rojas Rivero, Isabel Martínez Silva, Lucía Ayllón Valdés, Iraís Atencio Millán, Norbert Müller
Giardiasis is considered the most common intestinal parasitic disease in humans worldwide. In Cuba, this infection has particularly a strong clinical impact on the child population. Giardia duodenalis is a highly diverse protozoan, which comprises a complex of eight morphologically identical genetic assemblages, further divided into sub-assemblages. The present study used triose phosphate isomerase ( tpi ) and small-subunit ribosomal RNA (SSU rRNA) genes as genetic markers for the identification of G. duodenalis assemblages and sub-assemblages in correlation with clinical and epidemiological data in children attended at the Paediatric Hospital "William Soler" and at Pedro Kouri Institute, between 2015 and 2016...
August 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29761128/brain-computer-interfaces-for-post-stroke-motor-rehabilitation-a-meta-analysis
#4
REVIEW
María A Cervera, Surjo R Soekadar, Junichi Ushiba, José Del R Millán, Meigen Liu, Niels Birbaumer, Gangadhar Garipelli
Brain-computer interfaces (BCIs) can provide sensory feedback of ongoing brain oscillations, enabling stroke survivors to modulate their sensorimotor rhythms purposefully. A number of recent clinical studies indicate that repeated use of such BCIs might trigger neurological recovery and hence improvement in motor function. Here, we provide a first meta-analysis evaluating the clinical effectiveness of BCI-based post-stroke motor rehabilitation. Trials were identified using MEDLINE, CENTRAL, PEDro and by inspection of references in several review articles...
May 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29751940/could-human-bocavirus-be-a-causative-agent-of-parotitis-in-children
#5
Cristina Calvo, Claudia Millan, María Pilar Romero, Ana Méndez-Echevarría
No abstract text is available yet for this article.
May 8, 2018: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29746597/correction-human-alkaline-phosphatase-dephosphorylates-microbial-products-and-is-elevated-in-preterm-neonates-with-a-history-of-late-onset-sepsis
#6
Matthew Pettengill, Juan D Matute, Megan Tresenriter, Julie Hibbert, David Burgner, Peter Richmond, José Luis Millán, Al Ozonoff, Tobias Strunk, Andrew Currie, Ofer Levy
[This corrects the article DOI: 10.1371/journal.pone.0175936.].
2018: PloS One
https://www.readbyqxmd.com/read/29746465/the-cybathlon-bci-race-successful-longitudinal-mutual-learning-with-two-tetraplegic-users
#7
Serafeim Perdikis, Luca Tonin, Sareh Saeedi, Christoph Schneider, José Del R Millán
This work aims at corroborating the importance and efficacy of mutual learning in motor imagery (MI) brain-computer interface (BCI) by leveraging the insights obtained through our participation in the BCI race of the Cybathlon event. We hypothesized that, contrary to the popular trend of focusing mostly on the machine learning aspects of MI BCI training, a comprehensive mutual learning methodology that reinstates the three learning pillars (at the machine, subject, and application level) as equally significant could lead to a BCI-user symbiotic system able to succeed in real-world scenarios such as the Cybathlon event...
May 2018: PLoS Biology
https://www.readbyqxmd.com/read/29743480/femtosecond-x-ray-coherent-diffraction-of-aligned-amyloid-fibrils-on-low-background-graphene
#8
Carolin Seuring, Kartik Ayyer, Eleftheria Filippaki, Miriam Barthelmess, Jean-Nicolas Longchamp, Philippe Ringler, Tommaso Pardini, David H Wojtas, Matthew A Coleman, Katerina Dörner, Silje Fuglerud, Greger Hammarin, Birgit Habenstein, Annette E Langkilde, Antoine Loquet, Alke Meents, Roland Riek, Henning Stahlberg, Sébastien Boutet, Mark S Hunter, Jason Koglin, Mengning Liang, Helen M Ginn, Rick P Millane, Matthias Frank, Anton Barty, Henry N Chapman
Here we present a new approach to diffraction imaging of amyloid fibrils, combining a free-standing graphene support and single nanofocused X-ray pulses of femtosecond duration from an X-ray free-electron laser. Due to the very low background scattering from the graphene support and mutual alignment of filaments, diffraction from tobacco mosaic virus (TMV) filaments and amyloid protofibrils is obtained to 2.7 Å and 2.4 Å resolution in single diffraction patterns, respectively. Some TMV diffraction patterns exhibit asymmetry that indicates the presence of a limited number of axial rotations in the XFEL focus...
May 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29742017/constricted-migration-increases-dna-damage-and-independently-represses-cell-cycle
#9
Charlotte R Pfeifer, Yuntao Xia, Kuangzheng Zhu, Dazhen Liu, Jerome Irianto, Victor M Morales García, Leeza M Santiago Millán, Brandon Niese, Shane Harding, Dan Deviri, Roger A Greenberg, Dennis E Discher
Cell migration through dense tissues or small capillaries can elongate and even damage the nucleus, with any effect on cell cycle potentially impacting processes such as carcinogenesis. Here, nuclear rupture and DNA damage increase with constricted migration in different phases of cell cycle-which we show is partially repressed. We study several cancer lines that are contact inhibited or not and that exhibit diverse frequencies of nuclear lamina rupture after migration through small pores. DNA repair factors mis-localize after migration, and we consistently measure an excess of DNA damage based on pan-nucleoplasmic foci of phospho-activated ATM and γH2AX...
May 9, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29740900/adjusting-oral-oxybutynin-medication-for-hyperhidrosis-to-reflect-seasonal-temperature-variations
#10
Javier Del Boz, José Francisco Millán-Cayetano, Pablo García-Montero, Cristina García-Harana, Francisco Rivas-Ruiz, Magdalena de Troya-Martín
Most studies of oral oxybutynin (OOx) for the treatment of hyperhidrosis (HH) have assumed a stable treatment protocol, without taking into account adverse effects (AE) or seasonal variations in temperature. The objective is to evaluate adjusting the dose of OOx according to the time of year. Prospective study of patients who began OOx for HH between 2007 and 2017, and maintained treatment for at least 1 year, with a progressively increasing dose was performed. All patients were recommended to vary the dose of medication according to the time of year...
May 8, 2018: Dermatologic Therapy
https://www.readbyqxmd.com/read/29739035/next-generation-sequencing-panel-based-on-single-molecule-molecular-inversion-probes-for-detecting-genetic-variants-in-children-with-hypopituitarism
#11
María I Pérez Millán, Sebastian A Vishnopolska, Alexandre Z Daly, Juan P Bustamante, Adriana Seilicovich, Ignacio Bergadá, Débora Braslavsky, Ana C Keselman, Rosemary M Lemons, Amanda H Mortensen, Marcelo A Marti, Sally A Camper, Jacob O Kitzman
BACKGROUND: Congenital Hypopituitarism is caused by genetic and environmental factors. Over 30 genes have been implicated in isolated and/or combined pituitary hormone deficiency. The etiology remains unknown for up to 80% of the patients, but most cases have been analyzed by limited candidate gene screening. Mutations in the PROP1 gene are the most common known cause, and the frequency of mutations in this gene varies greatly by ethnicity. We designed a custom array to assess the frequency of mutations in known hypopituitarism genes and new candidates, using single molecule molecular inversion probes sequencing (smMIPS)...
May 8, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29732878/influence-of-three-commercial-graphene-derivatives-on-the-catalytic-properties-of-a-lactobacillus-plantarum-alpha-l-rhamnosidase-when-used-as-immobilization-matrices
#12
Noemí Antón-Millán, Javier Garcia-Tojal, Marta Marty-Roda, Sebastiano Garroni, Santiago Cuesta-López, Juan Antonio Tamayo-Ramos
The modification of carbon nanomaterials with biological molecules paves the way towards their use in biomedical and biotechnological applications, such as next generation biocatalytic processes, development of biosensors, implantable electronic devices, or drug delivery. In this study, different commercial graphene derivatives, namely, monolayer graphene oxide (GO), graphene oxide nanocolloids (GOC), and polycarboxylate functionalized graphene nanoplatelets (GN), were compared as biomolecule carrier matrices...
May 7, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29727687/variants-in-exosc9-disrupt-the-rna-exosome-and-result-in-cerebellar-atrophy-with-spinal-motor-neuronopathy
#13
David T Burns, Sandra Donkervoort, Juliane S Müller, Ellen Knierim, Diana Bharucha-Goebel, Eissa Ali Faqeih, Stephanie K Bell, Abdullah Y AlFaifi, Dorota Monies, Francisca Millan, Kyle Retterer, Sarah Dyack, Sara MacKay, Susanne Morales-Gonzalez, Michele Giunta, Benjamin Munro, Gavin Hudson, Mena Scavina, Laura Baker, Tara C Massini, Monkol Lek, Ying Hu, Daniel Ezzo, Fowzan S AlKuraya, Peter B Kang, Helen Griffin, A Reghan Foley, Markus Schuelke, Rita Horvath, Carsten G Bönnemann
The exosome is a conserved multi-protein complex that is essential for correct RNA processing. Recessive variants in exosome components EXOSC3, EXOSC8, and RBM7 cause various constellations of pontocerebellar hypoplasia (PCH), spinal muscular atrophy (SMA), and central nervous system demyelination. Here, we report on four unrelated affected individuals with recessive variants in EXOSC9 and the effect of the variants on the function of the RNA exosome in vitro in affected individuals' fibroblasts and skeletal muscle and in vivo in zebrafish...
May 3, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29721664/echocardiographic-measurements-of-epicardial-adipose-tissue-and-comparative-ability-to-predict-adverse-cardiovascular-outcomes-in-patients-with-coronary-artery-disease
#14
Julieta D Morales-Portano, Juan Ángel Peraza-Zaldivar, Juan A Suárez-Cuenca, Rocío Aceves-Millán, Lilia Amezcua-Gómez, Carlos H Ixcamparij-Rosales, Rafael Trujillo-Cortés, Rogelio Robledo-Nolasco, Paul Mondragón-Terán, Rebeca Pérez-Cabeza de Vaca, Rolando Hernández-Muñoz, Alberto Melchor-López, Mani A Vannan, Alberto Francisco Rubio-Guerra
The present study aimed to compare echocardiography measurements of epicardial adipose tissue (EAT) thickness and other risk factors regarding their ability to predict adverse cardiovascular outcomes in patients with coronary artery disease (CAD). Outcomes of 107 patients (86 males, 21 females, mean age 63.6 years old) submitted to diagnostic echocardiography and coronary angiography were prospectively analyzed. EAT (measures over the right ventricle, interventricular groove and complete bulk of EAT) and left ventricle ejection fraction (LVEF) were performed by echocardiography...
May 2, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29720720/gamma-aminobutyric-acid-gaba-receptors-genes-polymorphisms-and-risk-for-restless-legs-syndrome
#15
Félix Javier Jiménez-Jiménez, Gara Esguevillas, Hortensia Alonso-Navarro, Martín Zurdo, Laura Turpín-Fenoll, Jorge Millán-Pascual, Teresa Adeva-Bartolomé, Esther Cubo, Francisco Navacerrada, Gemma Amo, Ana Rojo-Sebastián, Lluisa Rubio, Mónica Díez-Fairén, Pau Pastor, Marisol Calleja, José Francisco Plaza-Nieto, Belén Pilo-de-la-Fuente, Margarita Arroyo-Solera, Esteban García-Albea, José A G Agúndez, Elena García-Martín
The possible role of gammaaminobutyric acid (GABA) in the pathophysiology of restless legs syndrome (RLS) is suggested by the symptomatic improvement achieved with GABAergic drugs. Thalamic GABA levels have shown positive correlation with periodic limb movements indices and with RLS severity. We tried to investigate the possible association between the most common single nucleotide polymorphisms (SNPs) in the GABA receptors (GABR) genes rho1, 2, and 3 (GABRR1, GABRR2, GABRR3), alpha4 (GABRA4), epsilon (GABRE), and theta (GABRQ) with the risk of developing RLS...
May 3, 2018: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/29717846/recognizing-and-managing-emerging-infectious-diseases-in-the-emergency-department-digest
#16
Ramón Millán, Deepti Thomas-Paulose, Daniel J Egan, Jeffrey Nusbaum, Nachi Gupta
With population shifts, increased travel, and climate change, the spread of emerging and re-emerging infections is increasing. Although encountering a patient with an emerging infection on any given emergency department shift is unlikely, missing a diagnosis could have profound consequences for the patient, healthcare workers, and the patient's close contacts. This review provides a framework to evaluate, diagnose, and treat a returning traveler with suspected Middle East respiratory syndrome, chikungunya virus, or Zika virus-3 recently emerged infections...
May 1, 2018: Emergency Medicine Practice
https://www.readbyqxmd.com/read/29712634/enhanced-phosphocholine-metabolism-is-essential-for-terminal-erythropoiesis
#17
Nai-Jia Huang, Ying-Cing Lin, Chung-Yueh Lin, Novalia Pishesha, Caroline A Lewis, Elizaveta Freinkman, Colin Farquharson, José Luis Millán, Harvey Lodish
Red cells contain a unique constellation of membrane lipids. While much is known about regulated protein expression, the regulation of lipid metabolism during erythropoiesis is poorly studied. Here we show that transcription of PHOSPHO1, a phosphoethanolamine and phosphocholine phosphatase that mediates the hydrolysis of phosphocholine to choline, is strongly upregulated during the terminal stages of erythropoiesis of both human and mouse erythropoiesis, concomitant with increased catabolism of phosphatidylcholine and phosphocholine as shown by global lipidomic analyses of mouse and human terminal erythropoiesis...
April 30, 2018: Blood
https://www.readbyqxmd.com/read/29706920/novice-shooters-with-lower-pre-shooting-alpha-power-have-better-performance-during-competition-in-a-virtual-reality-scenario
#18
Michael Pereira, Ferran Argelaguet, José Del R Millán, Anatole Lécuyer
Competition changes the environment for athletes. The difficulty of training for such stressful events can lead to the well-known effect of "choking" under pressure, which prevents athletes from performing at their best level. To study the effect of competition on the human brain, we recorded pilot electroencephalography (EEG) data while novice shooters were immersed in a realistic virtual environment representing a shooting range. We found a differential between-subject effect of competition on mu (8-12 Hz) oscillatory activity during aiming; compared to training, the more the subject was able to desynchronize his mu rhythm during competition, the better was his shooting performance...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29703137/genome-wide-identification-of-the-auxin-response-factor-gene-family-in-cicer-arietinum
#19
Jose V Die, Juan Gil, Teresa Millan
BACKGROUND: Auxin Response Factors act as critical components of the auxin-signaling pathway by regulating the transcription of auxin-responsive genes. The release of the chickpea reference genome provides an opportunity to identify and characterize the ARF gene family in this important legume by a data mining coupled by comparative genomics approaches. RESULTS: We performed a comprehensive characterization and analysis of 24 ARF genes in the chickpea reference genome...
April 27, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29701488/effectiveness-of-a-dietary-supplement-containing-hydrolyzed-collagen-chondroitin-sulfate-and-glucosamine-in-pain-reduction-and-functional-capacity-in-osteoarthritis-patients
#20
Jordi Puigdellivol, Carme Comellas Berenger, Miguel Ángel Pérez Fernández, Juan M Cowalinsky Millán, Christian Carreras Vidal, Inés Gil Gil, Julio Martínez Pagán, Borja Ruiz Nieto, Francisco Jiménez Gómez, Francesc X Comas Figuerola, María E Aguilar Hernández
This observational, open, multicenter clinical trial with a single treatment group aimed to evaluate the effectiveness of a dietary supplement whose main ingredients are hydrolyzed gelatin, chondroitin sulfate, glucosamine sulfate, and devil's claw and bamboo extracts for pain reduction and improvement of functional capacities in patients with osteoarthritis (OA) of the knee and/or hip (REDART study). In all, 130 patients with OA recruited from Spanish hospitals received the dietary supplement for 6 months...
April 27, 2018: Journal of Dietary Supplements
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