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https://www.readbyqxmd.com/read/28227811/detection-of-movement-related-cortical-potential-effects-of-causal-vs-non-causal-processing
#1
Omid G Sani, Ricardo Chavarriaga, Mohammad B Shamsollahi, Jose Del R Millan, Omid G Sani, Ricardo Chavarriaga, Mohammad B Shamsollahi, Jose Del R Millan, Mohammad B Shamsollahi, Omid G Sani, Ricardo Chavarriaga, Jose R Del Millan
Movement Related Cortical Potentials (MRCP) have been the subject of numerous studies. They accompany many self-initiated movements and this makes them a good candidate for incorporation in BCI paradigms. In this work we propose a novel experimental protocol involving natural controlling of a computer mouse and based on EEG recordings from 5 subjects, show that it elicits MRCP. We also show the feasibility of online detection of MRCP by implementing a classification based detection framework. Additionally, we discuss the adverse effects of causality restriction on detection performance by implementing an additional offline approach relaxing those restrictions and comparing the results...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224649/sex-chromosomal-abnormalities-associated-with-equine-infertility-validation-of-a-simple-molecular-screening-tool-in-the-purebred-spanish-horse
#2
G Anaya, A Molina, M Valera, M Moreno-Millán, P Azor, P Peral-García, S Demyda-Peyrás
Chromosomal abnormalities in the sex chromosome pair (ECAX and ECAY) are widely associated with reproductive problems in horses. However, a large proportion of these abnormalities remains undiagnosed due to the lack of an affordable diagnostic tool that allows for avoiding karyotyping tests. Hereby, we developed an STR (single-tandem-repeat)-based molecular method to determine the presence of the main sex chromosomal abnormalities in horses in a fast, cheap and reliable way. The frequency of five ECAX-linked (LEX026, LEX003, TKY38, TKY270 and UCDEQ502) and two ECAY-linked (EcaYH12 and SRY) markers was characterized in 261 Purebred Spanish Horses to determine the efficiency of the methodology developed to be used as a chromosomal diagnostic tool...
February 22, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28223221/the-atheroma-plaque-secretome-stimulates-the-mobilization-of-endothelial-progenitor-cells-ex-vivo
#3
Francisco M Vega, Violette Gautier, Cecilia M Fernandez-Ponce, Mª Jesús Extremera, A F Maarten Altelaar, Jaime Millan, Juan C Tellez, Jose A Hernandez-Campos, Rosario Conejero, Jorge Bolivar, Ricardo Pardal, Francisco J Garcia-Cózar, Enrique Aguado, Albert J R Heck, Mª Carmen Duran-Ruiz
Endothelial progenitor cells (EPCs) constitute a promising alternative in cardiovascular regenerative medicine due to their assigned role in angiogenesis and vascular repair. In response to injury, EPCs promote vascular remodeling by replacement of damaged endothelial cells and/or by secreting angiogenic factors over the damaged tissue. Nevertheless, such mechanisms need to be further characterized. In the current approach we have evaluated the initial response of early EPCs (eEPCs) from healthy individuals after direct contact with the factors released by carotid arteries complicated with atherosclerotic plaques (AP), in order to understand the mechanisms underlying the neovascularization and remodeling properties assigned to these cells...
February 18, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28217393/rare-association-of-secondary-superficial-siderosis-caused-by-a-fourth-ventricle-hemorrhagic-ependymoma-mimicking-a-cavernoma-case-report-and-literature-review
#4
Eduardo E Espinosa Rodríguez, Rodrigo Carrasco Moro, Juan S Martínez San Millán, Héctor G Pian Arias
BACKGROUND: The association of a hemorrhagic tumor with secondary superficial siderosis (SS) is a relatively rare although well described phenomenon. CASE DESCRIPTION: We present the case report of a 35-year-old male with a history of drowsiness, hypoacusia, drop attacks, and multidirectional nystagmus during the last 2 months, who presented with acute obstructive hydrocephalus caused by a fourth ventricle mass displaying radiological signs of repeated intra and extratumoral hemorrhage with SS...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28198360/secreted-clic3-drives-cancer-progression-through-its-glutathione-dependent-oxidoreductase-activity
#5
Juan R Hernandez-Fernaud, Elena Ruengeler, Andrea Casazza, Lisa J Neilson, Ellie Pulleine, Alice Santi, Shehab Ismail, Sergio Lilla, Sandeep Dhayade, Iain R MacPherson, Iain McNeish, Darren Ennis, Hala Ali, Fernanda G Kugeratski, Heba Al Khamici, Maartje van den Biggelaar, Peter V E van den Berghe, Catherine Cloix, Laura McDonald, David Millan, Aoisha Hoyle, Anna Kuchnio, Peter Carmeliet, Stella M Valenzuela, Karen Blyth, Huabing Yin, Massimiliano Mazzone, Jim C Norman, Sara Zanivan
The secretome of cancer and stromal cells generates a microenvironment that contributes to tumour cell invasion and angiogenesis. Here we compare the secretome of human mammary normal and cancer-associated fibroblasts (CAFs). We discover that the chloride intracellular channel protein 3 (CLIC3) is an abundant component of the CAF secretome. Secreted CLIC3 promotes invasive behaviour of endothelial cells to drive angiogenesis and increases invasiveness of cancer cells both in vivo and in 3D cell culture models, and this requires active transglutaminase-2 (TGM2)...
February 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28192350/sludge-reduction-via-biodegradation-of-the-endogenous-residue-xe-experimental-verification-and-modeling
#6
Cheikh Fall, Ericka L Millan-Lagunas, Carlos Lopez-Vazquez, Christine Maria Hooijmans, Yves Comeau
The feasibility of sludge reduction via the XE biodegradation process was explored both experimentally and through modeling, where the main focus was on determining the value of the bE parameter (first order degradation of XE) from a continuous process. Two activated sludge (AS) systems (30 L) were operated in parallel with synthetic wastewater during 16 months: a conventional activated sludge (CAS) system and a modified low-sludge production activated sludge (LSP-AS) process equipped with a side-stream digester unit (DU)...
February 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28190931/pendant-drop-method-coupled-to-ultraviolet-visible-spectroscopy-a-useful-tool-to-investigate-interfacial-phenomena
#7
Marco A R Andrade, Bruno Favarin, Rafael Derradi, Mayte Bolean, Ana Maria S Simão, José Luis Millán, Pietro Ciancaglini, Ana P Ramos
UV-vis spectroscopy is a powerful tool to investigate surface phenomena. Surface tension measurements coupled to spectroscopic techniques can help to elucidate how the interface organization influences the electronic properties of molecules. However, appreciable sample volumes are usually necessary to achieve strong signals during conduction of experiments. This study reports on the simultaneous acquisition of surface tension data and UV-vis spectra by axisymmetric drop shape analysis (ADSA) coupled to diffuse reflectance (DRUV) spectrophotometry using a pendant microliter-drop that requires small sample volumes and low analyte concentrations...
September 5, 2016: Colloids and Surfaces. A, Physicochemical and Engineering Aspects
https://www.readbyqxmd.com/read/28185675/-consensus-document-on-the-management-of-the-atherogenic-dyslipidaemia-of-the-spanish-society-of-arteriosclerosis
#8
Juan F Ascaso, Jesús Millán, Antonio Hernández-Mijares, Mariano Blasco, Ángel Brea, Ángel Díaz, Teresa Mantilla, Juan Pedro-Botet, Xavier Pintó
Positioning document and summary of recommendations recently published by the Working Group on Atherogenic Dyslipemia of the Spanish Society of Arteriosclerosis and by the European Society of Arteriosclerosis.
February 6, 2017: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/28183247/streptomyces-as-overexpression-system-for-heterologous-production-of-an-antimicrobial-peptide
#9
Marisol Roldán-Tapia, Jozef Anné, Ana Gisela Reyes, Ulises Carrasco, Cesar Millán-Pacheco, Javier Barrios-González, Armando Mejía
Defense mechanisms of plants against phytopathogens include cationic antimicrobial peptides (CAPs). The broad-spectrum activity of these peptides has been evaluated previously against different phytopathogens. Their lack of toxicity for plants and animals is a promising feature for pest control. Although, some attempts have been made previously in order to increase their heterologous expressions, the employed strategies have so far proven to be ineffective. Low production yield and elevated costs are the obstacles to overcome...
February 8, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28178518/an-evolutionarily-conserved-soxb-hdac2-crosstalk-regulates-neurogenesis-in-a-cnidarian
#10
Hakima Flici, Christine E Schnitzler, R Cathriona Millane, Graham Govinden, Amy Houlihan, Stephanie D Boomkamp, Sanbing Shen, Andreas D Baxevanis, Uri Frank
SoxB transcription factors and histone deacetylases (HDACs) are each major players in the regulation of neurogenesis, but a functional link between them has not been previously demonstrated. Here, we show that SoxB2 and Hdac2 act together to regulate neurogenesis in the cnidarian Hydractinia echinata during tissue homeostasis and head regeneration. We find that misexpression of SoxB genes modifies the number of neural cells in all life stages and interferes with head regeneration. Hdac2 was co-expressed with SoxB2, and its downregulation phenocopied SoxB2 knockdown...
February 7, 2017: Cell Reports
https://www.readbyqxmd.com/read/28174326/intravenous-thrombolysis-in-unknown-onset-stroke-results-from-the-safe-implementation-of-treatment-in-stroke-international-stroke-thrombolysis-registry
#11
Laura Dorado, Niaz Ahmed, Götz Thomalla, Manuel Lozano, Branko Malojcic, Mushtaq Wani, Mònica Millán, Ales Tomek, Antoni Dávalos
BACKGROUND AND PURPOSE: Stroke patients with unknown onset (UKO) are excluded from thrombolytic therapy. We aim to study the safety and efficacy of intravenous alteplase in ischemic stroke patients with UKO of symptoms compared with those treated within 4.5 hours in a large cohort. METHODS: Data were analyzed from 47 237 patients with acute ischemic stroke receiving intravenous tissue-type plasminogen activator in hospitals participating in the Safe Implementation of Treatment in Stroke-International Stroke Thrombolysis Registry between 2010 and 2014...
February 7, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28166591/search-of-the-p-m918t-mutation-in-the-ret-oncogene-in-mexican-adult-patients-with-medullary-thyroid-carcinoma
#12
Erika Ruiz-Garcia, Silvia Vidal-Millan, Alicia Lopez-Yañez, José Antonio Posada Torres, Jorge Alberto Guadarrama-Orozco, Leonardo Saul Lino-Silva, Abelardo Meneses-Garcia, Horacio Astudillo-de la Vega, Martin Granados Garcia
Inherited mutations in the RET proto-oncogene, which encodes a receptor tyrosine kinase, predispose individuals to the multiple endocrine neoplasia type 2 (MEN 2) cancer syndromes. The major component tumor of these syndromes is medullary thyroid carcinoma (MTC). To date, somatic mutations in RET have been identified in tumors from individuals with MEN 2 finding. RET M918T mutation is present in 95% of the MEN2B cases, and approximately 50% of sporadic MTCs harbor this mutation. We performed a mutational analysis in 17 cases of Medullary thyroid carcinoma, the somatic missense mutation at codon 918 of RET was found in 2 of the 17 MTCs, and one case presented MEN2 phenotype including MTC...
February 6, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28154372/therapeutic-effect-of-the-immunomodulatory-drug-lenalidomide-but-not-pomalidomide-in-experimental-models-of-rheumatoid-arthritis-and-inflammatory-bowel-disease
#13
Belen Lopez-Millan, Rafael Diaz de la Guardia, Heleia Roca-Ho, Carmen M García-Herrero, Jessie R Lavoie, Michael Rosu-Myles, Elena Gonzalez-Rey, Francisco O'Valle, Gabriel Criado, Mario Delgado, Pablo Menendez
Thalidomide is an immunomodulatory drug (IMiD) with proven therapeutic action in several autoimmune/inflammatory diseases; however, its inherent high toxicity has led to the development of more powerful and safer thalidomide analogs, including lenalidomide and pomalidomide. These are new generation IMiDs that exhibit direct antitumor activity as well as anti-inflammatory/immunomodulatory properties, and are FDA-approved for the treatment of several hematological malignances. Here we investigated the potential therapeutic effects of lenalidomide and pomalidomide in several experimental murine models of autoimmune/inflammatory diseases: 2,4,6-trinitrobenzene sulfonic acid- and dextran sulfate sodium-induced inflammatory bowel disease and type II collagen-induced arthritis...
February 3, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28153804/putrescine-essential-factor-for-in%C3%A2-vitro-proliferation-of-babesia-bovis
#14
C Rojas-Martínez, R I Rodríguez-Vivas, J V Figueroa Millán, K Y Acosta Viana, E J Gutiérrez Ruiz, J A Álvarez Martínez
This study reports the effect of putrescine addition, either alone or in combination with insulin, transferrin and selenite (ITS), to serum-free Advanced DMEM/F12 (A-DMEM/F12) medium, on the in vitro culture of Babesia bovis and using a perfusion bioreactor to improve efficiency of the process. A B. bovis strain previously adapted to proliferate in serum-free medium (Bbovis-SF) was evaluated using eight increasing concentrations of putrescine. The percentage of parasitized erythrocytes (PPE) obtained from cultures supplemented with 0...
January 30, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28148909/en-bloc-transplant-of-the-liver-kidney-and-pancreas-experience-from-a-latin-american-transplant-center
#15
Luis A Caicedo, Jorge I Villegas, Oscar Serrano, Mauricio Millán, Mauricio Sepúlveda, Diego Jiménez, Jairo García, Juan G Posada, Liliana Mesa, Carlos Duran, Johanna Schweineberg, Diana Dávalos, Eliana Manzi, Angie Sabogal, Ana María Aristizabal, Gabriel J Echeverri
BACKGROUND En-bloc transplantation is a surgical procedure in which multiple organs are transplanted simultaneously. It has some similarities with multi-organ transplantation but offers certain advantages. This report highlights the experience of our interdisciplinary group regarding the treatment and follow-up of patients who received en-bloc transplantation, with the aim of encouraging the development of this surgical technique. CASE REPORT The first case is a 38-year-old patient with type 1 diabetes mellitus, liver cirrhosis, and chronic kidney failure who received an en-bloc transplant of the liver, pancreas, and kidney with no intraoperative complications...
February 2, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28146352/a-spectroscopic-and-molecular-simulation-approach-toward-the-binding-affinity-between-lysozyme-and-phenazinium-dyes-an-effect-on-protein-conformation
#16
Sabera Millan, Lakkoji Satish, Krishnendu Bera, B Susrisweta, Durg Vijay Singh, Harekrushna Sahoo
A comparative study of binding interaction between Safranin O (SO) and Neutral Red (NR) with lysozyme (Lyz) has been reported using several spectroscopic methods along with computational approaches. Steady-state fluorescence measurements revealed static quenching as the major quenching mechanism in Lyz-SO and Lyz-NR interaction, which is further supported by time-resolved fluorescence and UV-vis measurements. Additionally, binding and thermodynamic parameters of these interactions are calculated from temperature dependent fluorescence data...
February 13, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28146155/predatory-activity-of-butlerius-nematodes-and-nematophagous-fungi-against-haemonchus-contortus-infective-larvae
#17
Manoel Eduardo da Silva, Miguel Angel Mercado Uriostegui, Jair Millán-Orozco, Pedro Mendoza de Gives, Enrique Liébano Hernández, Fabio Ribeiro Braga, Jackson Victor de Araújo
The purpose of this study was to evaluate the predatory activity of the nematode Butlerius spp. and fungal isolates of Duddingtonia flagrans, Clonostachys rosea, Arthrobotrys musiformis and Trichoderma esau against H. contortus infective larvae (L3) in grass pots. Forty-eight plastic gardening pots containing 140 g of sterile soil were used. Panicum spp. grass seeds (200 mg) were sown into each pot and individually watered with 10 mL of tap water. Twelve days after seeding, the pots were randomly divided into 6 groups (n=8)...
January 26, 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/28143603/classification-of-upper-limb-center-out-reaching-tasks-by-means-of-eeg-based-continuous-decoding-techniques
#18
Andrés Úbeda, José M Azorín, Ricardo Chavarriaga, José Del R Millán
BACKGROUND: One of the current challenges in brain-machine interfacing is to characterize and decode upper limb kinematics from brain signals, e.g. to control a prosthetic device. Recent research work states that it is possible to do so based on low frequency EEG components. However, the validity of these results is still a matter of discussion. In this paper, we assess the feasibility of decoding upper limb kinematics from EEG signals in center-out reaching tasks during passive and active movements...
February 1, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28141909/improving-the-outcomes-of-organs-obtained-from-controlled-donation-after-circulatory-death-donors-using-abdominal-normothermic-regional-perfusion
#19
Eduardo Miñambres, Borja Suberviola, Beatriz Dominguez-Gil, Emilio Rodrigo, Juan Carlos Ruiz-San Millan, Juan Carlos Rodríguez-San Juan, Maria Angeles Ballesteros
Donation after circulatory death (DCD) has experienced a significant expansion over the last decade. However, warm ischemia results in a greater risk for transplantation. Indeed, controlled DCD (cDCD) was associated with inferior outcomes compared to donation after brain death. The use of abdominal normothermic regional perfusion (nRP) to restore blood flow prior to organ recovery in cDCD has been proposed as a better alternative than rapid recovery to reverse the effect of ischemia and improve recipients' outcome...
January 31, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28139846/genotype-and-phenotype-in-12-additional-individuals-with-satb2-associated-syndrome
#20
Yuri A Zarate, Louisa Kalsner, Alice Basinger, Julie R Jones, Chumei Li, Marta Szybowska, Zhuo Luan Xu, Samantha Vergano, Aisling R Caffrey, Cruz Velasco Gonzalez, Holly Dubbs, Elaine Zackai, Francisca Millan, Aida Telegrafi, Berivan Baskin, Richard Person, Jennifer L Fish, David B Everman
SATB2-associated syndrome (SAS) is a multisystemic disorder caused by alterations of the SATB2 gene. We describe the phenotype and genotype of twelve individuals with 10 unique (de novo in 11 of 11 tested) pathogenic variants (1 splice site, 5 frameshift, 3 nonsense, 2 missense) in SATB2 and review all cases reported in the published literature caused by point alterations thus far. In the cohort here described, developmental delay with severe speech compromise, facial dysmorphism, and dental anomalies were present in all cases...
January 31, 2017: Clinical Genetics
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