Yanan Song, Yajie Liu, Yi Yuan, Xixi Jia, Wenchao Zhang, Geng Wang, Yunyang Jia, Xiaoxiao Wang, Lei Liu, Weitian Li, Xinping Li, Nan Cai, Chang Liu, Yue Li, Yongzheng Han, Yang Zhou, Xinning Mi, Chengmei Shi, John Q Wang, Alain Vuylsteke, Xiangyang Guo, Zhengqian Li
BACKGROUND: Circadian rhythm disturbance is common postoperatively in older patients with hip fractures, which may contribute to the development of postoperative delirium (POD). As a reliable biomarker of endogenous circadian rhythms, melatonin regulates the sleep-wake cycle and environmental adaptation, and its secretory rhythm may be modified by anaesthesia and surgery. This study compared the impact of subarachnoid anaesthesia (SA) and general anaesthesia (GA), on the peak of melatonin secretion (primary outcome), the circadian rhythm of melatonin, cortisol and sleep, and the POD incidence (secondary outcome)...
August 2021: EBioMedicine