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Andrew Rundle

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https://www.readbyqxmd.com/read/29773186/association-between-cadmium-and-androgen-receptor-protein-expression-differs-in-prostate-tumors-of-african-american-and-european-american-men
#1
Christine M Neslund-Dudas, Russell B McBride, Ashoka Kandegedara, Benjamin A Rybicki, Oleksandr N Kryvenko, Dhananjay Chitale, Nilesh Gupta, Sean R Williamson, Craig G Rogers, Carlos Cordon-Cardo, Andrew G Rundle, Albert M Levin, Q Ping Dou, Bharati Mitra
Cadmium is a known carcinogen that has been implicated in prostate cancer, but how it affects prostate carcinogenesis in humans remains unclear. Evidence from basic science suggests that cadmium can bind to the androgen receptor causing endocrine disruption. The androgen receptor is required for normal prostate development and is the key driver of prostate cancer progression. In this study, we examined the association between cadmium content and androgen receptor protein expression in prostate cancer tissue of African American (N = 22) and European American (N = 30) men...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29762655/longitudinal-physical-activity-patterns-among-older-adults-a-latent-transition-analysis
#2
Stephen J Mooney, Spruha Joshi, Magdalena Cerdá, Gary J Kennedy, John R Beard, Andrew G Rundle
Most epidemiologic studies of physical activity measure either total energy expenditure or engagement in a single activity type, such as walking. These approaches may gloss over important nuances in activity patterns. We performed a latent transition analysis to identify patterns of activity types as well as neighborhood and individual determinants of changes in those activity patterns over two years in a cohort of 2,023 older adult residents of New York City, NY, surveyed between 2011 and 2013. We identified seven latent classes: 1) Mostly Inactive, 2) Walking, 3) Exercise, 4) Household Activities and Walking, 5) Household Activities and Exercise, 6) Gardening and Household Activities, and 7) Gardening, Household Activities, and Exercise...
May 14, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29729943/phenotype-penetrance-and-treatment-of-133-ctla-4-insufficient-individuals
#3
Charlotte Schwab, Annemarie Gabrysch, Peter Olbrich, Virginia Patiño, Klaus Warnatz, Daniel Wolff, Akihiro Hoshino, Masao Kobayashi, Kohsuke Imai, Masatoshi Takagi, Ingunn Dybedal, Jamanda A Haddock, David Sansom, Jose M Lucena, Maximilian Seidl, Annette Schmitt-Gräff, Veronika Reiser, Florian Emmerich, Natalie Frede, Alla Bulashevska, Ulrich Salzer, Desirée Schubert, Seiichi Hayakawa, Satoshi Okada, Maria Kanariou, Zeynep Yesim Kucuk, Hugo Chapdelaine, Lenka Petruzelkova, Zdenek Sumnik, Anna Sediva, Mary Slatter, Peter D Arkwright, Andrew Cant, Hanns-Martin Lorenz, Thomas Giese, Vassilios Lougaris, Alessandro Plebani, Christina Price, Kathleen E Sullivan, Michel Moutschen, Jiri Litzman, Tomas Freiberger, Frank L van de Veerdonk, Mike Recher, Michael H Albert, Fabian Hauck, Suranjith Seneviratne, Jana Pachlopnik Schmid, Antonios Kolios, Gary Unglik, Christian Klemann, Carsten Speckmann, Stephan Ehl, Alan Leichtner, Richard Blumberg, Andre Franke, Scott Snapper, Sebastian Zeissig, Charlotte Cunningham-Rundles, Lisa Giulino-Roth, Olivier Elemento, Gregor Dückers, Tim Niehues, Eva Fronkova, Veronika Kanderová, Craig D Platt, Janet Chou, Talal Chatila, Raif Geha, Elizabeth McDermott, Su Bunn, Monika Kurzai, Ansgar Schulz, Laia Alsina, Ferran Casals, Angela Deyà-Martinez, Sophie Hambleton, Hirokazu Kanegane, Kjetil Taskén, Olaf Neth, Bodo Grimbacher
BACKGROUND: Cytotoxic-T-lymphocyte-antigen-4 (CTLA-4) is a negative immune regulator. Heterozygous CTLA4 germline mutations can cause a complex immune dysregulation syndrome in humans. OBJECTIVE: To characterize the penetrance, the clinical features and the best treatment options in 133 CTLA4 mutation carriers. METHODS: Genetics, clinical features, laboratory values, and outcome of treatment options were assessed in a worldwide cohort of CTLA4 mutation carriers...
May 3, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29508714/infant-rhinitis-and-watery-eyes-predict-school-age-exercise-induced-wheeze-emergency-department-visits-and-respiratory-related-hospitalizations
#4
Khalil W Savary, Rachel L Miller, Emilio Arteaga-Solis, Lori Hoepner, Luis M Acosta, Frederica P Perera, Andrew G Rundle, Inge F Goldstein, Matthew S Perzanowski
BACKGROUND: Rhinitis and conjunctivitis are often linked to asthma development through an allergic pathway. However, runny nose and watery eyes can result from nonallergic mechanisms. These mechanisms can also underlie exercise-induced wheeze (EIW), which has been associated with urgent medical visits for asthma, independent of other indicators of asthma severity or control. OBJECTIVE: To test the hypothesis that rhinitis or watery eyes without cold symptoms (RWWC) in infancy predict development of EIW and urgent respiratory-related medical visits at school age, independent of seroatopy...
March 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29214316/association-between-hospital-financial-distress-and-immediate-breast-reconstruction-surgery-after-mastectomy-among-women-with-ductal-carcinoma-in-situ
#5
Catherine A Richards, Andrew G Rundle, Jason D Wright, Dawn L Hershman
Importance: Hospital financial distress (HFD) is a state in which a hospital is at risk of closure because of its financial condition. Hospital financial distress may reduce the services a hospital can offer, particularly unprofitable ones. Few studies have assessed the association of HFD with quality of care. Objective: To examine the association between HFD and receipt of immediate breast reconstruction surgery after mastectomy among women diagnosed with ductal carcinoma in situ (DCIS)...
December 6, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29192337/pediatric-emergency-department-visits-for-pedestrian-and-bicyclist-injuries-in-the-us
#6
Katherine Wheeler-Martin, Stephen J Mooney, David C Lee, Andrew Rundle, Charles DiMaggio
BACKGROUND: Despite reductions in youth pedestrian and bicyclist deaths over the past two decades, these injuries remain a substantial cause of morbidity and mortality for children and adolescents. There is a need for additional information on non-fatal pediatric pedestrian injuries and the role of traumatic brain injury (TBI), a leading cause of acquired disability. METHODS: Using a multi-year national sample of emergency department (ED) records, we estimated annual motorized-vehicle related pediatric pedestrian and bicyclist (i...
December 1, 2017: Injury Epidemiology
https://www.readbyqxmd.com/read/29020137/residential-socioeconomic-food-and-built-environments-and-glycemic-control-in-individuals-with-diabetes-in-new-york-city-2007-2013
#7
Bahman P Tabaei, Andrew G Rundle, Winfred Y Wu, Carol R Horowitz, Victoria Mayer, Daniel M Sheehan, Shadi Chamany
This study examined the longitudinal associations between residential environment factors and glycemic control in 182,756 adults with diabetes in New York City (2007-2013). Glycemic control was defined as hemoglobin A1c (A1C) <7%. We constructed residential-level measures and performed principle component analysis to formulate a residential composite score. Based on this score, we divided residential areas into quintiles, with the lowest and highest quintiles reflecting the least advantaged and most advantaged residential environments...
August 17, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28899030/mooney-et-al-respond-to-observing-neighborhood-physical-disorder
#8
Stephen J Mooney, Michael D M Bader, Gina S Lovasi, Julien O Teitler, Karestan C Koenen, Allison E Aiello, Sandro Galea, Emily Goldmann, Daniel M Sheehan, Andrew G Rundle
No abstract text is available yet for this article.
August 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28899028/street-audits-to-measure-neighborhood-disorder-virtual-or-in-person
#9
Stephen J Mooney, Michael D M Bader, Gina S Lovasi, Julien O Teitler, Karestan C Koenen, Allison E Aiello, Sandro Galea, Emily Goldmann, Daniel M Sheehan, Andrew G Rundle
Neighborhood conditions may influence a broad range of health indicators, including obesity, injury, and psychopathology. In particular, neighborhood physical disorder-a measure of urban deterioration-is thought to encourage crime and high-risk behaviors, leading to poor mental and physical health. In studies to assess neighborhood physical disorder, investigators typically rely on time-consuming and expensive in-person systematic neighborhood audits. We compared 2 audit-based measures of neighborhood physical disorder in the city of Detroit, Michigan: One used Google Street View imagery from 2009 and the other used an in-person survey conducted in 2008...
August 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28826915/socioeconomic-vs-health-related-factors-associated-with-google-searches-for-gluten-free-diet
#10
Monika Laszkowska, Henna Shiwani, Julia Belluz, Jonas F Ludvigsson, Peter H R Green, Daniel Sheehan, Andrew Rundle, Benjamin Lebwohl
No abstract text is available yet for this article.
February 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28630656/physical-activity-black-carbon-exposure-and-dna-methylation-in-the-foxp3-promoter
#11
Stephanie Lovinsky-Desir, Kyung Hwa Jung, Jacqueline R Jezioro, David Z Torrone, Mariangels de Planell-Saguer, Beizhan Yan, Frederica P Perera, Andrew G Rundle, Matthew S Perzanowski, Steven N Chillrud, Rachel L Miller
BACKGROUND: Physical activity is associated with improvement in lung function; however, pollution exposure during physical activity can lead to a transient reduction in lung function. This paradoxical relationship may be linked to altered T regulatory (Treg) cell activity, which increases with exercise and suppresses airway inflammation, but decreases in association with exposure to air pollution. To clarify these relationships, we investigated buccal cell DNA methylation of the forkhead box p3 (FOXP3) gene promoter, a proposed biomarker of Treg activity...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28409682/distinct-serum-sphingolipid-profiles-among-school-aged-children-with-exercise-induced-wheeze-and-asthma-persistence
#12
Matthew S Perzanowski, Jennie G Ono, Luis M Acosta, Benjamin I Kim, Adnan Divjan, Rachel Miller, Andrew Rundle, Stefan Worgall, Tilla S Worgall
No abstract text is available yet for this article.
April 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28382385/neighborhood-determinants-of-mood-and-anxiety-disorders-among-men-who-have-sex-with-men-in-new-york-city
#13
Magdalena Cerdá, Vijay Nandi, Victoria Frye, James E Egan, Andrew Rundle, James W Quinn, Daniel Sheehan, Donald R Hoover, Danielle C Ompad, Hong Van Tieu, Emily Greene, Beryl Koblin
PURPOSE: We examined the relationship between economic, physical, and social characteristics of neighborhoods, where men who have sex with men (MSM) lived and socialized, and symptom scores of depression and generalized anxiety disorder (GAD). METHODS: Participants came from a cross-sectional study of a population-based sample of New York City MSM recruited in 2010-2012 (n = 1126). Archival and survey-based data were obtained on neighborhoods, where the men lived and where they socialized most often...
June 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28349547/larger-men-have-larger-prostates-detection-bias-in-epidemiologic-studies-of-obesity-and-prostate-cancer-risk
#14
Andrew Rundle, Yun Wang, Sudha Sadasivan, Dhananjay A Chitale, Nilesh S Gupta, Deliang Tang, Benjamin A Rybicki
BACKGROUND: Obesity is associated with risk of aggressive prostate cancer (PCa), but not with over-all PCa risk. However, obese men have larger prostates which may lower biopsy accuracy and cause a systematic bias toward the null in epidemiologic studies of over-all risk. METHODS: Within a cohort of 6692 men followed-up after a biopsy or transurethral resection of the prostate (TURP) with benign findings, a nested case-control study was conducted of 495 prostate cancer cases and controls matched on age, race, follow-up duration, biopsy versus TURP, and procedure date...
June 2017: Prostate
https://www.readbyqxmd.com/read/28154108/contextual-correlates-of-physical-activity-among-older-adults-a-neighborhood-environment-wide-association-study-ne-was
#15
EDITORIAL
Stephen J Mooney, Spruha Joshi, Magdalena Cerdá, Gary J Kennedy, John R Beard, Andrew G Rundle
Background: Few older adults achieve recommended physical activity levels. We conducted a "neighborhood environment-wide association study (NE-WAS)" of neighborhood influences on physical activity among older adults, analogous, in a genetic context, to a genome-wide association study. Methods: Physical Activity Scale for the Elderly (PASE) and sociodemographic data were collected via telephone survey of 3,497 residents of New York City aged 65 to 75 years. Using Geographic Information Systems, we created 337 variables describing each participant's residential neighborhood's built, social, and economic context...
April 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28116590/relationship-between-recreational-resources-in-the-school-neighborhood-and-changes-in-fitness-in-new-york-city-public-school-students
#16
Carla P Bezold, James H Stark, Andrew Rundle, Kevin Konty, Sophia E Day, James Quinn, Kathryn Neckerman, Ana V Diez Roux
Physical fitness in children has many beneficial effects, including the maintenance of a healthy weight. The built environment may influence youths' physical fitness by encouraging physical activity. This paper assessed whether higher density of parks, playgrounds, and sports facilities around a school is related to improvements in fitness in middle school boys and girls. Fitness scores and other student covariates collected as part of NYC FITNESSGRAM between the 2006-2007 and 2010-2011 school years were linked with school neighborhood data on characteristics of the built environment for NYC public school students in grades 6-8...
February 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28108872/neighborhood-disorder-and-physical-activity-among-older-adults-a-longitudinal-study
#17
Stephen J Mooney, Spruha Joshi, Magdalena Cerdá, Gary J Kennedy, John R Beard, Andrew G Rundle
Neighborhood physical disorder-the visual indications of neighborhood deterioration-may inhibit outdoor physical activity, particularly among older adults. However, few previous studies of the association between neighborhood disorder and physical activity have focused on this sensitive population group, and most have been cross-sectional. We examined the relationship between neighborhood physical disorder and physical activity, measured using the Physical Activity Scale for the Elderly (PASE), in a three-wave longitudinal study of 3497 New York City residents aged 65-75 at baseline weighted to be representative of the older adult population of New York City...
February 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28049071/pathways-from-neighborhood-poverty-to-depression-among-older-adults
#18
Spruha Joshi, Stephen J Mooney, Andrew G Rundle, James W Quinn, John R Beard, Magdalena Cerdá
The pathways through which neighborhood poverty can affect resident depression are still unknown. We investigated mechanisms through which neighborhood poverty may influence depression among older adults. Participants were drawn from the New York City Neighborhood and Mental Health in the Elderly Study II, a 3-wave study of adults aged 65-75 (n=3,497) at baseline. Neighborhood poverty and homicide were associated with depressive symptoms at follow-up waves (RR:1.20, 95%CI: 1.05, 1.36; RR: 1.09, 95%CI: 1.02, 1...
January 2017: Health & Place
https://www.readbyqxmd.com/read/27987434/disparities-in-self-rated-health-across-generations-and-through-the-life-course
#19
Bruce G Link, Ezra S Susser, Pam Factor-Litvak, Dana March, Katrina L Kezios, Gina S Lovasi, Andrew G Rundle, Shakira F Suglia, Kim M Fader, Howard F Andrews, Eileen Johnson, Piera M Cirillo, Barbara A Cohn
Extensive evidence leads us to expect that health disparities by race and socioeconomic status found in one generation might be reproduced in the next. To the extent that this occurs it is important to assess life course processes responsible for the reproduction. Prospective evidence concerning such life course processes is hard to come by as it requires long-term follow-up of individuals from childhood through adult life. We present data from the Child Health and Development Disparities study that provides evidence relevant to this issue with respect to self-rated health...
February 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/27869994/neighborhood-disadvantage-and-life-space-mobility-are-associated-with-incident-falls-in-community-dwelling-older-adults
#20
Alexander X Lo, Andrew G Rundle, David Buys, Richard E Kennedy, Patricia Sawyer, Richard M Allman, Cynthia J Brown
OBJECTIVES: To determine the relationship between neighborhood-level socioeconomic characteristics, life-space mobility, and incident falls in community-dwelling older adults. DESIGN: Prospective, observational cohort study with a baseline in-home assessment and 6-month telephone follow-up. SETTING: Central Alabama. PARTICIPANTS: Community-dwelling adults aged 65 and older recruited from a random sample of Medicare beneficiaries (N = 1,000)...
November 2016: Journal of the American Geriatrics Society
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