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https://www.readbyqxmd.com/read/28918324/simultaneous-determination-and-pharmacokinetic-study-of-twelve-bioactive-compounds-in-rat-plasma-after-intravenous-administration-of-xuebijing-injection-by-uhplc-q-orbitrap-hrms
#1
Lihua Zuo, Qiuyue Zhong, Zhenhui Wang, Zhi Sun, Lin Zhou, Zhuolun Li, Tanye Xu, Yingying Shi, Jinfa Tang, Shuzhang Du, Xiaojian Zhang
Xuebijing injection (XBJ) is a traditional Chinese herbal prescription widely used in the treatment of sepsis. Extensive studies revealed that the major bioactive constituents of XBJ injection, including phenolic acids, flavonoids, monoterpene glycosides, lactones and organic acids, play an important role in the treatment. In this study, a rapid, sensitive and accurate ultra high performance liquid chromatography - Q Exactive hybrid quadrupole - orbitrap high-resolution accurate mass spectrometry (UHPLC-Q-Orbitrap HRMS) method was developed for simultaneous determination of twelve bioactive compounds in rat plasma after intravenous administration of XBJ injection...
September 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28918133/short-communication-short-term-intravenous-amino-acid-infusions-as-a-method-to-detect-limiting-amino-acids-in-dairy-cattle-diets
#2
Roni Yair, Michael S Allen
We hypothesized that the addition of limiting AA increases dry matter intake (DMI) by reducing anaplerosis and hepatic oxidation. Accordingly, the objective of this work was to examine the effects of short-term intravenous infusions of Met, Lys, and His (which are considered the most limiting AA) on DMI as a method to detect whether specific AA are limiting in dairy cow diets. We conducted 4 experiments using Holstein cows in the immediate postpartum period to address this objective. The first experiment used 4 cows 6 to 10 d postpartum (PP) in a 4 × 4 Latin square design with 1-d periods including 12 h for infusions and 12 h for recovery...
September 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28917894/structural-functional-and-ph-sensitive-release-characteristics-of-water-soluble-polysaccharide-from-the-seeds-of-albizia-lebbeck-l
#3
Chekuri Ashok Kumar Varma, K Jayaram Kumar
Plant polysaccharides, generally regarded as safe (GRAS), are gaining importance as excipients in drug delivery. Therefore, the current paper presents the studies on structural, functional and drug release study of water soluble polysaccharide (ALPS) from seeds of Albizia lebbeck L. High swelling, water holding capacity, foam stability and lower moisture content suggests its use as additive in food preparations. The apparent molecular weight of polysaccharide was found to be 1.98×10(2)kDa. Monosaccharide composition analysis indicated that ALPS consists of mannose (4...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917757/innovative-thin-layer-chromatographic-method-combined-with-fluorescence-detection-for-specific-determination-of-febuxostat-application-in-biological-fluids
#4
Abdel-Maaboud I Mohamed, Mahmoud A Omar, Sayed M Derayea, Mohamed A Hammad, Abobakr A Mohamed
A newly developed thin-layer chromatographic (TLC) method coupled with fluorescence detection for specific determination of Febuxostat (FEB) was designed. The proposed method adopts exposure of FEB on a developed TLC plate to hydrochloric acid vapors, resulting in a large enhancement of its weak fluorescence, permitting its specific and sensitive determination in real human plasma and urine after excitation at 345nm on 60 F254 silica gel plates using toluene-ethyl acetate-methanol-glacial acetic acid; (30:10:5:0...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28916569/effects-of-anthocyanins-on-cardiometabolic-health-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#5
REVIEW
LiPing Yang, WenHua Ling, ZhiCheng Du, YuMing Chen, Dan Li, ShiZhou Deng, ZhaoMin Liu, LiLi Yang
Numerous clinical trials have examined the role of anthocyanins on cardiometabolic health, but their effects have not been quantitatively synthesized and systematically evaluated. The aim of our study was to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) assessing the effects of anthocyanins on glycemic regulation and lipid profiles in both healthy populations and those with cardiometabolic diseases. The MEDLINE, EMBASE, Cochrane database, OVID EBM Reviews, and clinicaltrials...
September 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28910410/the-function-of-drosophila-larval-class-iv-dendritic-arborization-sensory-neurons-in-the-larval-pupal-transition-is-separable-from-their-function-in-mechanical-nociception-responses
#6
Hannah E Brown, Trishna Desai, Allison J Murphy, Harshida Pancholi, Zachary W Schmidt, Hannah Swahn, Eric C Liebl
The sensory and physiological inputs which govern the larval-pupal transition in Drosophila, and the neuronal circuity that integrates them, are complex. Previous work from our laboratory identified a dosage-sensitive genetic interaction between the genes encoding the Rho-GEF Trio and the zinc-finger transcription factor Sequoia that interfered with the larval-pupal transition. Specifically, we reported heterozygous mutations in sequoia (seq) dominantly exacerbated the trio mutant phenotype, and this seq-enhanced trio mutant genotype blocked the transition of third instar larvae from foragers to wanderers, a requisite behavioral transition prior to pupation...
2017: PloS One
https://www.readbyqxmd.com/read/28905241/photostability-issues-in-pharmaceutical-dosage-forms-and-photostabilization
#7
REVIEW
Karthik Yadav Janga, Tamara King, Nan Ji, Sandeep Sarabu, Gauri Shadambikar, Sagar Sawant, Pengchong Xu, Michael A Repka, S Narasimha Murthy
Photodegradation is one of the major pathways of the degradation of drugs. Some therapeutic agents and excipients are highly sensitive to light and undergo significant degradation, challenging the quality and the stability of the final product. The adequate knowledge of photodegradation mechanisms and kinetics of photosensitive therapeutic entities or excipients is a pivotal aspect in the product development phase. Hence, various pharmaceutical regulatory agencies, across the world, mandated the industries to assess the photodegradation of pharmaceutical products from manufacturing stage till storage, as per the guidelines given in the International Conference on Harmonization (ICH)...
September 13, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28904531/potential-therapeutic-mechanisms-and-tracking-of-transplanted-stem-cells-implications-for-stroke-treatment
#8
REVIEW
Yanhong Zhang, Honghong Yao
Stem cell therapy is a promising potential therapeutic strategy to treat cerebral ischemia in preclinical and clinical trials. Currently proposed treatments for stroke employing stem cells include the replacement of lost neurons and integration into the existing host circuitry, the release of growth factors to support and promote endogenous repair processes, and the secretion of extracellular vesicles containing proteins, noncoding RNA, or DNA to regulate gene expression in recipient cells and achieve immunomodulation...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28903828/pharmacokinetics-of-single-bolus-subcutaneous-cefovecin-in-c57bl-6-mice
#9
Kevin L Sanders, Esperanza Bas, Sherry K Cox, Daniel E Rothen
Because of its extended half-life, cefovecin is a broad-spectrum cephalosporin antibiotic commonly used to treat dermatitis in dogs and cats. A single injection in dogs can yield an effective plasma concentration for as long as 14 d, depending on the strain of Staphylococcus and for as long as 7 d in cats for the treatment of Pasteurella multocida. In the laboratory animal setting, C57BL/6 mice are commonly affected with dermatologic conditions that make these animals unsuitable for experiments. Therefore, we performed this pharmacokinetic study to determine whether cefovecin would be of benefit in mice...
September 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28887098/investigation-of-a-new-ph-responsive-nanoparticulate-pore-former-for-controlled-release-enteric-coating-with-improved-processability-and-stability
#10
Kuan Chen, Hao Han R Chang, Alireza Shalviri, Jason Li, Jamie Anne Lugtu-Pe, Anil Kane, Xiao Yu Wu
Water-soluble polymers are often used as pore formers to tailor permeability of film-forming hydrophobic polymers on coated dosage forms. However, their addition to a coating formulation could significantly increase the viscosity thus making the coating process difficult. Moreover, the dissolution of pore formers after oral administration could compromise film integrity resulting in undesirable, inconsistent release profiles. Therefore, a non-leaching, pH-responsive nanoparticulate pore former is proposed herein to preserve film integrity and maintain pH-dependent permeability...
September 5, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28882111/tsh-cut-off-point-based-on-depression-in-hypothyroid-patients
#11
A Talaei, N Rafee, F Rafei, A Chehrei
BACKGROUND: The prevalence of depressive symptoms in hypothyroidism is high. Considering that hypothyroidism and depression share some clinical features, some researchers use the "brain hypothyroidism" hypothesis to explain the pathogenesis of depression. We aimed to detect a new TSH cut-off value in hypothyroidism based on depression symptoms. METHODS: A cross-sectional study was conducted on hypothyroid patients referred to endocrine clinics. Individuals who had developed euthyroid state under treatment with levothyroxine with TSH levels of 0...
September 7, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28877233/high-level-dietary-cadmium-exposure-is-associated-with-global-dna-hypermethylation-in-the-gastropod-hepatopancreas
#12
Dragos V Nica, Cristina Popescu, George A Draghici, Florina-Maria Andrica, Ionela A Privistirescu, Iosif I Gergen, Reinhard Stöger
5-methylcytosine (5mC) is a key epigenetic mark which influences gene expression and phenotype. In vertebrates, this epigenetic mark is sensitive to Cd exposure, but there is no information linking such an event with changes in global 5mC levels in terrestrial gastropods despite their importance as excellentecotoxicological bioindicators of metal contamination. Therefore, we first evaluated total 5mC content in DNA of the hepatopancreas of adult Cantareus aspersus with the aim to determine whether this epigenetic mark is responsive to Cd exposure...
2017: PloS One
https://www.readbyqxmd.com/read/28871226/pharmacokinetic-and-pharmacodynamic-evaluation-of-marbofloxacin-and-pk-pd-modeling-against-escherichia-coli-in-pigs
#13
Zhixin Lei, Qianying Liu, Jincheng Xiong, Bing Yang, Shuaike Yang, Qianqian Zhu, Kun Li, Shishuo Zhang, Jiyue Cao, Qigai He
The aim of this study was to evaluate the activity of marbofloxacin and establish the optimal dose regimens for decreasing the development of fluoroquinolone resistance in pigs against Escherichia coli with ex vivo pharmacokinetic/pharmacodynamic (PK/PD) modeling. The recommended dose (2 mg/kg body weight) of marbofloxacin was orally administered in healthy pigs. The ileum content and plasma were both collected for the determination of marbofloxacin. The main parameters of Cmax, AUC0-24 h, AUC, Ke, t1/2ke, MRT and Clb were 11...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28863777/dosage-sensitive-genes-in-evolution-and-disease
#14
REVIEW
Alan M Rice, Aoife McLysaght
For a subset of genes in our genome a change in gene dosage, by duplication or deletion, causes a phenotypic effect. These dosage-sensitive genes may confer an advantage upon copy number change, but more typically they are associated with disease, including heart disease, cancers and neuropsychiatric disorders. This gene copy number sensitivity creates characteristic evolutionary constraints that can serve as a diagnostic to identify dosage-sensitive genes. Though the link between copy number change and disease is well-established, the mechanism of pathogenicity is usually opaque...
September 1, 2017: BMC Biology
https://www.readbyqxmd.com/read/28860714/sensitization-of-gastric-cancer-cells-to-alkylating-agents-by-glaucocalyxin-b-via-cell-cycle-arrest-and-enhanced-cell-death
#15
Muhammad Saif Ur Rahman, Ling Zhang, Lingyan Wu, Yuqiong Xie, Chunchun Li, Jiang Cao
Severe side effects are major problems with chemotherapy of gastric cancer (GC). These side effects can be reduced by using sensitizing agents in combination with therapeutic drugs. In this study, the low/nontoxic dosage of glaucocalyxin B (GLB) was used with other DNA linker agents mitomycin C (MMC), cisplatin (DDP), or cyclophosphamide (CTX) to treat GC cells. Combined effectiveness of GLB with drugs was determined by proliferation assay. The molecular mechanisms associated with cell proliferation, migration, invasion, cell cycle, DNA repair/replication, apoptosis, and autophagy were investigated by immunoblotting for key proteins involved...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28859329/familial-mediterranean-fever-in-children-and-adolescents-factors-for-colchicine-dosage-and-predicting-parameters-for-dose-increase
#16
Anne-Marie Knieper, Jens Klotsche, Elke Lainka, Thomas Berger, Frank Dressler, Annette F Jansson, Christoph Rietschel, Prasad T Oommen, Rainer Berendes, Tim Niehues, Ulrich Neudorf, Dirk Foell, Helmut Wittkowski, Tilmann Kallinich
Objectives: The aim was to analyse factors influencing the individual colchicine dose in children with FMF, to evaluate the impact of dose adjustment on the clinical course and inflammation and to identify clinical parameters and biomarkers that predict dose increase in the near future. Methods: Data from 409 paediatric FMF patients (4566 visits) derived from the national auto-inflammatory diseases registry were analysed. Serum concentrations of S100 molecules were determined by ELISA...
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28858781/epidermal-electrode-technology-for-detecting-ultrasonic-perturbation-of-sensory-brain-activity
#17
Stanley Huang, Jonathan A N Fisher, Meijun Ye, Yun-Soung Kim, Rui Ma, Marjan Nabili, Victor Krauthamer, Matthew R Myers, Todd P Coleman, Cristin G Welle
OBJECTIVE: We aim to demonstrate the in vivo capability of a wearable sensor technology to detect localized perturbations of sensory-evoked brain activity. METHODS: Cortical somatosensory evoked potentials (SSEPs) were recorded in mice via wearable, flexible epidermal electrode arrays. We then utilized the sensors to explore the effects of transcranial focused ultrasound, which noninvasively induced neural perturbation. SSEPs recorded with flexible epidermal sensors were quantified and benchmarked against those recorded with invasive epidural electrodes...
August 29, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28855971/the-effect-of-nipped-b-like-nipbl-haploinsufficiency-on-genome-wide-cohesin-binding-and-target-gene-expression-modeling-cornelia-de-lange-syndrome
#18
Daniel A Newkirk, Yen-Yun Chen, Richard Chien, Weihua Zeng, Jacob Biesinger, Ebony Flowers, Shimako Kawauchi, Rosaysela Santos, Anne L Calof, Arthur D Lander, Xiaohui Xie, Kyoko Yokomori
BACKGROUND: Cornelia de Lange syndrome (CdLS) is a multisystem developmental disorder frequently associated with heterozygous loss-of-function mutations of Nipped-B-like (NIPBL), the human homolog of Drosophila Nipped-B. NIPBL loads cohesin onto chromatin. Cohesin mediates sister chromatid cohesion important for mitosis but is also increasingly recognized as a regulator of gene expression. In CdLS patient cells and animal models, expression changes of multiple genes with little or no sister chromatid cohesion defect suggests that disruption of gene regulation underlies this disorder...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28855357/chemogenomic-landscape-of-runx1-mutated-aml-reveals-importance-of-runx1-allele-dosage-in-genetics-and-glucocorticoid-sensitivity
#19
Laura Simon, Vincent-Philippe Lavallée, Marie-Eve Bordeleau, Jana Krosl, Irene Baccelli, Geneviève Boucher, Bernhard Lehnertz, Jalila Chagraoui, Tara MacRae, Réjean Ruel, Yves A Chantigny, Sébastien Lemieux, Anne Marinier, Josée Hébert, Guy Sauvageau
PURPOSE: RUNX1-mutated (RUNX1mut) Acute Myeloid Leukemia (AML) is associated with adverse outcome, highlighting the urgent need for a better genetic characterization of this AML subgroup and for the design of efficient therapeutic strategies for this disease. Towards this goal, we further dissected the mutational spectrum and gene expression profile of RUNX1mut AML and correlated these results to drug sensitivity to identify novel compounds targeting this AML subgroup. EXPERIMENTAL DESIGN: RNA-sequencing of 47 RUNX1mut primary AML specimens was performed and sequencing results were compared to those of RUNX1 wild-type samples...
August 30, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28851212/lignosulfonate-improves-photostability-and-bioactivity-of-abscisic-acid-under-uv-radiation
#20
Fei Gao, Sha Yu, Qun Tao, Weiming Tan, Liusheng Duan, Zhaohu Li, Haixin Cui
Abscisic acid (ABA), as a commonly used plant growth regulator, is easy to be degraded and lose its bioactivity under sunshine. To select an eco-friendly and efficient photoprotectant for the improvement of photostability and bioactivity of ABA when exposed to UV light, we tested the effects of three biodegradable natural derived high polymers - sodium lignosulfonates 3A (molecular weight (MW) > 50000, degree of sulfonation (DS) 0.48), NA (20000 < MW < 50000, DS 0.7) and calcium lignosulfonate CASA (MW < 20000, DS 0...
August 29, 2017: Journal of Agricultural and Food Chemistry
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