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https://www.readbyqxmd.com/read/28549649/prolonged-deficits-of-associative-motor-learning-in-cynomolgus-monkeys-after-long-term-administration-of-phencyclidine
#1
Bing Wu, Xu-Dong Zhao, Hui-Min Zhang, Xuan Li, Guang-Yan Wu, Ying-Shan Yang, Chao-Yang Tian, Jian-Feng Sui
Phencyclidine (PCP) is a potent drug of abuse that induces sustained schizophrenia-like symptoms in humans by blocking neurotransmission at N-methyl-D-aspartate (NMDA)-type glutamate receptors. Alterations in NMDA receptor function have been linked to numerous behavioral deficits and cognitive dysfunction. Classical eye-blink conditioning (EBC), including delay (dEBC) and trace (tEBC) pafadigms, provides an effective means to study the neurobiology of associative motor learning in rodents, mammals and primates...
May 23, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28548560/microalgal-oil-from-schizochytrium-sp-prevents-hfd-induced-abdominal-fat-accumulation-in-mice
#2
Jinhui Yu, Yong Ma, Jie Sun, Liyuan Ran, Youwei Li, Ning Wang, Tao Yu, Wenting Gao, Wenbin Jia, Rujiao Jiang, Meihua Guo, Yuping Bi, Yingjie Wu
OBJECTIVE: Dietary n-3 polyunsaturated fatty acids (PUFAs), especially eicosapentaenoic acids (EPA) and docosahexaenoic acid (DHA), are proved to be effective in obesity reduction. Microalgal oil (MO) is an important alternative source of n-3 PUFAs that effectively alleviates obesity. The aim of the present study was to explore the anti-obesity effects of microalgal oil from Schizochytrium sp. (SMO) and to compare the effects of 2 SMOs (SMO1 and SMO2) with different levels of purity of n-3 PUFAs on high fat diet (HFD)-induced obesity in male C57BL/6J mice...
May 26, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28537580/effects-of-supplementation-with-quercetin-on-plasma-c-reactive-protein-concentrations-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#3
REVIEW
M Mohammadi-Sartang, Z Mazloom, S Sherafatmanesh, M Ghorbani, Donya Firoozi
Promising experimental studies suggest that quercetin has potential anti-inflammatory effects. However, the results of current clinical trials on quercetin's effects on the C-reactive protein (CRP), a sensitive inflammatory biomarker, are ambiguous. We conducted a meta-analysis of available randomized controlled trials (RCTs) to resolve this inconsistency and quantify the net effect of quercetin on circulating CRP concentrations. A systematic search was performed in several databases including SCOPUS, PubMed-Medline and Google Scholar until 16 June 2016...
May 24, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28535989/slow-release-of-etoposide-from-dextran-conjugation-shifts-etoposide-activity-from-cytotoxicity-to-differentiation-a-promising-tool-for-dosage-control-in-anticancer-metronomic-therapy
#4
Milena De Nicola, Emanuele Bruni, Enrico Traversa, Lina Ghibelli
Drug conjugation, improving drug stability, solubility and body permanence, allow achieving impressive results in tumor control. Here, we show that conjugation may provide a straightforward method to administer drugs by the emerging anticancer metronomic approach, presently consisting of low, repeated doses of cytotoxic drugs used in traditional chemotherapy, thus reducing toxicity without reducing efficiency; however, low dose maintenance in tumor sites is difficult. We show that conjugating the antitumor drug etoposide to dextran via pH-sensitive bond produces slow releasing, apoptosis-proficient conjugates rapidly internalized into acidic lysosomes; importantly, release of active etoposide requires cell internalization and acidic pH...
May 20, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28532242/antioxidant-supplementation-a-linchpin-in-radiation-induced-enteritis
#5
Mumtaz Anwar, Shabeer Ahmad, Reyhan Akhtar, Akhtar Mahmood, Safrun Mahmood
Radiation enteritis is one of the most feared complications of abdominal and pelvic regions. Thus, radiation to abdominal or pelvic malignancies unavoidably injures the intestine. Because of rapid cell turnover, the intestine is highly sensitive to radiation injury, which is the limiting factor in the permissible dosage of irradiation. Bowel injuries such as fistulas, strictures, and chronic malabsorption are potentially life-threatening complications and have an impact on patient quality of life. The incidence of radiation enteritis is increasing because of the current trend of combined chemotherapy and radiation...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28532100/the-controlled-drug-release-by-ph-sensitive-molecularly-imprinted-nanospheres-for-enhanced-antibacterial-activity
#6
Congyang Mao, Xianzhou Xie, Xiangmei Liu, Zhenduo Cui, Xianjin Yang, K W K Yeung, Haobo Pan, Paul K Chu, Shuilin Wu
In this study, we prepared pH-sensitive hybrid nanospheres through the implementation of a facile molecularly imprinted polymer (MIP) technique combined with a UV-initiated precipitation polymerization method using vancomycin (VA) for the templates. During the course of this investigation, both 2-hydroxyethyl methacrylate (HEMA) and 2-(diethylamino) ethyl methacrylate (DEAEMA) were utilized as the functional monomers, while ethylene glycol dimethacrylate (EGDMA) was used as a cross-linker. The obtained MIP nanospheres exhibited well-controlled particle size, with a drug loading capacity of about 17%, much higher than that of the non-imprinted polymer (NIP) nanospheres (5%)...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531189/tandem-duplications-lead-to-novel-expression-patterns-through-exon-shuffling-in-drosophila-yakuba
#7
Rebekah L Rogers, Ling Shao, Kevin R Thornton
One common hypothesis to explain the impacts of tandem duplications is that whole gene duplications commonly produce additive changes in gene expression due to copy number changes. Here, we use genome wide RNA-seq data from a population sample of Drosophila yakuba to test this 'gene dosage' hypothesis. We observe little evidence of expression changes in response to whole transcript duplication capturing 5' and 3' UTRs. Among whole gene duplications, we observe evidence that dosage sharing across copies is likely to be common...
May 22, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28530088/-common-treatment-for-acute-tonsillitis-in-the-community
#8
Oded Mazor, Martine Granek-Catarivas, Shmuel Giveon
BACKGROUND: Streptococcal tonsillitis among adults is a common diagnosis. There is wide agreement regarding the recommended treatment, which is Phenoxymethyl Penicillin (Penicillin V) 1000 mg daily (usually 500 mg BID for 10 days). OBJECTIVES: Description of the variability of routine antibiotic treatment prescribed by family physicians in the community for the treatment of acute tonsillitis (which represents a common diagnosis in primary care), and observation of the prescribed antibiotics adherence to the guidelines...
September 2016: Harefuah
https://www.readbyqxmd.com/read/28524034/-value-of-preoperative-pulmonary-artery-diastolic-pressure-on-predicting-primary-graft-dysfunction-after-bilateral-lung-transplantation-for-patients-with-idiopathic-pulmonary-fibrosis
#9
Feng Zhang, Hongyang Xu, Shuyun Jiang, Jiaqiong Li, Shunmei Lu, Dapeng Wang, Zhidong Zang, Hong Pan, Jingyu Chen
OBJECTIVE: To analyze the value of the potential risk factors on predicting primary graft dysfunction (PGD) after bilateral lung transplantation for the patients with idiopathic pulmonary fibrosis (IPF). METHODS: A retrospective study was conducted. Fifty-eight patients with IPF who underwent the bilateral lung transplantation admitted to Wuxi People's Hospital Affiliated to Nanjing Medical University from June 2014 to March 2017 were enrolled. The grade 3 PGD happened within 72 hours after transplantation was taken as the outcome event, and these patients were divided into PGD and non-PGD groups...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28516780/dual-colored-carbon-dot-ratiometric-fluorescent-test-paper-based-on-a-specific-spectral-energy-transfer-for-semiquantitative-assay-of-copper-ions
#10
Cui Liu, Dianhua Ning, Cheng Zhang, Zhengjie Liu, Ruilong Zhang, Jun Zhao, Tingting Zhao, Bianhua Liu, Zhongping Zhang
Classical pH test papers are widely used to measure the acid-base degree of media in a qualitative or semiquantitative manner. However, the extension of portable and inexpensive methods to a wide range of analytes so as to eliminate the tediousness of instrumental assays remains unsuccessful. Here, we report a novel kind of dual-colored carbon dot (CD) ratiometric fluorescent test paper for the semiquantitative assay of copper ions (Cu(2+)) by a dose-sensitive color evolution. The preparation of the test paper is based on the following two interesting findings: on the one hand, residual p-phenylenediamine at the surface of as-synthesized red CDs (r-CDs) efficiently binds Cu(2+) ions to produce a strong visible absorption that overlaps the emission of blue CDs (b-CDs); on the other hand, the Cu(2+) ions render the adsorption of small b-CDs onto the surface of larger r-CDs through their dual-coordinating interactions with the surface ligands of both r-CDs and b-CDs...
May 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28516499/spectrofluorometric-determination-of-clonazepam-in-dosage-forms-application-to-content-uniformity-testing-and-human-plasma
#11
Fathalla Belal, Fawzia Ibrahim, Zainab Sheribah, Heba Alaa
The present paper describes a developed and validated simple, highly sensitive and cost-effective spectrofluorometric method for determination of clonazepam (CNP). The proposed method depends on forming a highly fluorescent product through the reduction of CNP with Zn/HCl. The produced fluorophore exhibits a strong fluorescence at λem 350 nm after excitation at λex 250 nm. The use of carboxymethylcellulose (CMC) greatly enhanced the fluorescence intensity of the produced fluorophore to the extent of about 100%...
May 18, 2017: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/28515788/genomic-imprinting-does-not-reduce-the-dosage-of-ube3a-in-neurons
#12
Paul R Hillman, Sarah G B Christian, Ryan Doan, Noah D Cohen, Kranti Konganti, Kory Douglas, Xu Wang, Paul B Samollow, Scott V Dindot
BACKGROUND: The ubiquitin protein E3A ligase gene (UBE3A) gene is imprinted with maternal-specific expression in neurons and biallelically expressed in all other cell types. Both loss-of-function and gain-of-function mutations affecting the dosage of UBE3A are associated with several neurodevelopmental syndromes and psychological conditions, suggesting that UBE3A is dosage-sensitive in the brain. The observation that loss of imprinting increases the dosage of UBE3A in brain further suggests that inactivation of the paternal UBE3A allele evolved as a dosage-regulating mechanism...
2017: Epigenetics & Chromatin
https://www.readbyqxmd.com/read/28514755/a-novel-serum-based-biomarker-panel-has-complementary-ability-to-preclude-presence-of-early-lung-cancer-for-low-dose-ct-ldct
#13
Xiaobing Wang, Xiuyi Zhi, Zhaogang Yang, Haimei Tian, Yanfen Li, Mo Li, Wenya Zhao, Chao Zhang, Teng Wang, Jing Liu, Di Shen, Cuining Zheng, Dan Zhao, Sheng Yang, Jun Qi, Hongwu Xin, Alexander Stojadinovic, Itzhak Avital, L James Lee, Jianyu Rao, Wei Zhang
Low Dosage Computerized Tomography (LDCT) has been shown to improve early detection of lung cancer and mortality rates in high-risk individuals, which was, however, limited by specifically coverage for heavy smokers and high rates of false positivity. Here, we aim to investigate a novel biomarker for early detection of lung cancer, and further extend to concentrate high-risk subjects for increasing specificity and coverage of LDCT. We performed retrospective blinded evaluation of lung cancer and healthy controls in training and validation cohorts...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28508293/influenza-infection-and-heart-failure-vaccination-may-change-heart-failure-prognosis
#14
REVIEW
Nikolaos P E Kadoglou, Frank Bracke, Tim Simmers, Sotirios Tsiodras, John Parissis
The interaction of influenza infection with the pathogenesis of acute heart failure (AHF) and the worsening of chronic heart failure (CHF) is rather complex. The deleterious effects of influenza infection on AHF/CHF can be attenuated by specific immunization. Our review aimed to summarize the efficacy, effectiveness, safety, and dosage of anti-influenza vaccination in HF. In this literature review, we searched MEDLINE and EMBASE from January 1st 1966 to December 31st, 2016, for studies examining the association between AHF/CHF, influenza infections, and anti-influenza immunizations...
May 15, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28501735/dose-and-time-dependent-effects-of-mirtazapine-on-the-expression-of-cocaine-induced-behavioral-sensitization-in-rats
#15
Susana Barbosa-Méndez, Maura Matus-Ortega, Anabel Flores-Zamora, Noe Jurado, Alberto Salazar-Juárez
Relapse to cocaine use is a major problem in the clinical treatment of cocaine dependence. Antidepressant medications have been studied as potential therapeutic drugs to relieve a cocaine dependence disorder. Mirtazapine is an antidepressant implicated in reducing behavioral alterations induced by drugs of abuse. We have reported elsewhere that 30mg/kg mirtazapine administered for 30 days during cocaine extinction significantly attenuated the induction and expression of cocaine-induced locomotor sensitization and decreased the duration of the cocaine-induced locomotor effect...
May 5, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28498911/different-chromatographic-methods-for-simultaneous-determination-of-mefenamic-acid-and-two-of-its-toxic-impurities
#16
Martha M Morcoss, Nada S Abdelwahab, Nouruddin W Ali, Mohammed T Elsaady
Two sensitive, accurate and precise chromatographic methods mentioned as TLC-densitometric method and RP-HPLC-DAD method, were developed and validated for the simultaneous determination of mefenamic acid (MEF) and its two toxic impurities, benzoic acid (BA) and 2,3-dimethylaniline (DMA). In the proposed TLC-densitometric method a developing system consisting of chloroform:acetone:acetic acid:ammonia solution(70:30:2:2, v/v/v/v) was used, TLC aluminum plates 60 F254 was used as a stationary phase and the separated bands were UV-scanned at 225 nm...
May 11, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28495958/maternal-torso-like-coordinates-tissue-folding-during-drosophila-gastrulation
#17
Travis K Johnson, Karyn A Moore, James C Whisstock, Coral G Warr
The rapid and orderly folding of epithelial tissue during developmental processes such as gastrulation requires the precise coordination of changes in cell shape. Here, we report that the perforin-like protein Torso-like (Tsl), the key extracellular determinant for Drosophila embryonic terminal patterning, also functions to control epithelial morphogenesis. We find that tsl null mutants display a ventral cuticular hole phenotype that is independent of the loss of terminal structures, and arises as a consequence of mesoderm invagination defects...
May 11, 2017: Genetics
https://www.readbyqxmd.com/read/28489614/validation-of-innovative-techniques-for-monitoring-nociception-during-general-anesthesia-a-clinical-study-using-tetanic-and-intracutaneous-electrical-stimulation
#18
Sandra Funcke, Sven Sauerlaender, Hans O Pinnschmidt, Bernd C Saugel, Kai Bremer, Daniel A Reuter, Rainer Nitzschke
BACKGROUND: This study compares the analgesic indices Analgesia Nociception Index (heart rate variability), Surgical Pleth Index (photoplethysmography), and pupillary dilatation, to heart rate, mean arterial pressure, and bispectral index, with regard to diagnostic accuracy and prediction probability for nociceptive response. The primary endpoint was the correlation between Δ values and the remifentanil dose administered. METHODS: We anesthetized 38 patients with propofol and increasing doses of remifentanil and applied standardized tetanic and intracutaneous electrical painful stimulations on each analgesic level...
May 10, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28489216/the-role-of-surgery-in-the-management-of-women-with-gestational-trophoblastic-disease
#19
Lana DE Lourdes Aguiar Lima, Lílian Padron, Raphael Câmara, Sue Yazaki Sun, Jorge Rezende, Antônio Braga
The Gestational Trophoblastic Disease includes an interrelated group of diseases originating from placental tissue, with distinct behaviors concerning local invasion and metastasis. The high sensitivity of the serial dosages of human chorionic gonadotrophin, combined with advances in chemotherapy treatment, have made gestational trophoblastic neoplasia curable, most often through chemotherapy. However, surgery remains of major importance in the management of patients with gestational trophoblastic disease, improving their prognosis...
January 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/28487438/the-niemann-pick-c1-gene-interacts-with-a-high-fat-diet-to-promote-weight-gain-through-differential-regulation-of-central-energy-metabolism-pathways
#20
Joseph J Castillo, David Jelinek, Hao Wei, Nicholas P Gannon, Roger A Vaughan, L John Horwood, F John Meaney, Randi Garcia-Smith, Kristina A Trujillo, Randall A Heidenreich, David Meyre, Robert A Orlando, Renee C LeBoeuf, William S Garver
A genome-wide association study (GWAS) reported that common variation in the human Niemann-Pick C1 gene (NPC1) is associated with morbid adult obesity. This study was confirmed using our BALB/cJ Npc1 mouse model, whereby heterozygous mice (Npc1(+/-)) with decreased gene dosage were susceptible to weight gain when fed a high-fat diet (HFD) compared to homozygous normal mice (Npc1(+/+)) fed the same diet. The objective for our current study was to validate this Npc1 gene-diet interaction using statistical modeling with fitted growth trajectories, conduct body weight analyses for different measures, and define the physiological basis responsible for weight gain...
May 9, 2017: American Journal of Physiology. Endocrinology and Metabolism
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