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https://www.readbyqxmd.com/read/28737428/chromatographic-determination-of-zonisamide-topiramate-and-sulpiride-in-plasma-by-a-fluorescent-turn-on-chemosensor
#1
Fawzia A Ibrahim, Amira F El-Yazbi, Mira M Wagih, Magda A Barary
AIM: Antiepileptics (AEDs) and antipsychotics are often coprescribed. Interactions between these drugs may affect both efficacy and toxicity. Therefore, drug monitoring is necessary for appropriate dosage adjustments. MATERIALS & METHODS: Specific 'turn-on' chemosensor, 4-chloro-7-nitrobenzofurazan is used for selective and sensitive determination of two AEDs: zonisamide (ZON) and topiramate (TOP) with the antipsychotic sulpiride (SUL) in epileptic patients' plasma followed by reversed-phase-HPLC separation without any interference...
July 24, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28737123/development-and-validation-of-eco-friendly-liquid-chromatographic-and-spectrophotometric-methods-for-simultaneous-determination-of-coformulated-drugs-phenylephrine-hydrochloride-and-prednisolone-acetate
#2
Nadia M Mostafa, Ghada M Elsayed, Nagiba Y Hassan, Dina A El Mously
Five simple, sensitive, and eco-friendly LC and UV spectrophotometric methods have been developed for the simultaneous determination of phenylephrine hydrochloride (PHE) and prednisolone acetate (PRD) in their combined dosage form. The first method was reversed-phase (RP) LC using methanol–water–heptane-1-sulfonic acid sodium salt (75 + 25 + 0.1, v/v/w) as a mobile phase. Separation was achieved using an XSelect HSS reversed-phase C18 analytical column (250 × 4.6 mm, 5µm). The flow rate was 1...
July 24, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28736786/an-enzyme-free-flow-cytometric-bead-assay-for-the-sensitive-detection-of-micrornas-based-on-click-nucleic-acid-ligation-mediated-signal-amplification
#3
Yan Qi, Liying Qiu, Wenjiao Fan, Chenghui Liu, Zhengping Li
A versatile flow cytometric bead assay (FCBA) coupled with a completely enzyme-free signal amplification mechanism is developed for the sensitive detection of microRNAs (miRNAs). This new strategy integrates click chemistry-mediated ligation chain reaction (CLCR) with hybridization chain reaction (HCR) for enzyme-free signal amplification on magnetic beads (MBs), and a flow cytometer for the robust fluorescence readout of the MBs. Firstly, target miRNA can initiate CLCR on the surface of MBs based on the click chemical ligation between dibenzocyclooctyne (DBCO)- and azide-modified single-stranded DNA (ssDNA) probes, and the amount of ligated ssDNA sequences on the MBs will be proportional to the dosage of target miRNA...
July 24, 2017: Analyst
https://www.readbyqxmd.com/read/28733015/ultrasonic-assisted-synthesis-of-polyvinyl-alcohol-phytic-acid-polymer-film-and-its-thermal-stability-mechanical-properties-and-surface-resistivity
#4
Jihui Li, Yongshen Li, Yunna Song, Shuai Niu, Ning Li
In this paper, polyvinyl alcohol/phytic acid polymer (PVA/PA polymer) was synthesized through esterification reaction of PVA and PA in the case of acidity and ultrasound irradiation and characterized, and PVA/PA polymer film was prepared by PVA/PA polymer and characterized, and the influence of dosage of PA on the thermal stability, mechanical properties and surface resistivity of PVA/PA polymer film were researched, and the influence of sonication time on the mechanical properties of PVA/PA polymer film was investigated...
November 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28729838/detection-of-emodin-derived-glutathione-adduct-in-normal-rats-administered-with-large-dosage-of-polygoni-multiflori-radix
#5
Li-Long Jiang, Dong-Sheng Zhao, Ya-Xi Fan, Qiong Yu, Ping Li, Hui-Jun Li
Polygoni Multiflori Radix (PMR) has been commonly used as a tonic in China for centuries. PMR-associated hepatotoxicity has been drawing increasingly more attention in recent years in parallel with its wide utilization. Anthraquinones (AQs) are recognized as the main hepatotoxic components in PMR. However, the exact underlying mechanism of AQs poisoning is still not fully understood. Herein, we proposed a hypothesis that metabolic activation of AQs such as emodin was involved in PMR-induced liver injury, AQs followed to generate the electrophilic reactive metabolites and subsequently formed covalent adduct with cellular nucleophiles in the liver to exert hepatotoxicity...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28728121/effect-of-residual-h2o2-from-advanced-oxidation-processes-on-subsequent-biological-water-treatment-a-laboratory-batch-study
#6
Feifei Wang, Doris van Halem, Gang Liu, Karin Lekkerkerker-Teunissen, Jan Peter van der Hoek
H2O2 residuals from advanced oxidation processes (AOPs) may have critical impacts on the microbial ecology and performance of subsequent biological treatment processes, but little is known. The objective of this study was to evaluate how H2O2 residuals influence sand systems with an emphasis on dissolved organic carbon (DOC) removal, microbial activity change and bacterial community evolution. The results from laboratory batch studies showed that 0.25 mg/L H2O2 lowered DOC removal by 10% while higher H2O2 concentrations at 3 and 5 mg/L promoted DOC removal by 8% and 28%...
July 15, 2017: Chemosphere
https://www.readbyqxmd.com/read/28725977/the-effect-of-vitamin-d-and-calcium-supplementation-in-pediatric-steroid-sensitive-nephrotic-syndrome
#7
Sushmita Banerjee, Surupa Basu, Ananda Sen, Jayati Sengupta
BACKGROUND: Low serum levels of total 25-hydroxycholecalciferol (25(OH)D) occur in nephrotic syndrome (NS). We aimed to assess the effects of vitamin D3 and calcium supplementation on 25(OH)D levels, bone mineralization, and NS relapse rate in children with steroid-sensitive NS. METHODS: A randomized controlled trial (RCT) was performed in children with steroid-sensitive NS. The treatment group received vitamin D3 (60,000 IU orally, weekly for 4 weeks) and calcium supplements (500 to 1,000 mg/day for 3 months) after achieving NS remission...
July 19, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28724846/metabolic-and-inflammatory-changes-with-orlistat-and-sibutramine-treatment-in-obese-malaysian-subjects
#8
Belqes Abdullah Mohammad Al-Tahami, Ab Aziz Al-Safi Ismail, Zulkefli Sanip, Zurkurnai Yusoff, Tg Muzaffar Tm Shihabudin, Taran Singh Pall Singh, Aida Hanum Ghulam Rasool
INTRODUCTION: Obesity is associated with numerous health problems, particularly metabolic and cardiovascular complications. This study aimed to assess the effects that, nine months of pharmacological intervention with orlistat or sibutramine, on obese Malaysians' body weight and compositions, metabolic profiles and inflammatory marker. METHODS: Seventy-six obese subjects were randomly placed into two groups. The first group received three daily 120 mg dosages of orlistat for nine months (n=39), and the second group received a once daily 10 or 15 mg dosage of sibutramine for nine months (n=37)...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28722424/metabolic-study-of-cancer-cells-using-a-ph-sensitive-hydrogel-nanofiber-light-addressable-potentiometric-sensor
#9
Parmiss Mojir Shaibani, Hashem Etayash, Selvaraj Naicker, Kamaljit Kaur, Thomas Thundat
We report a simple, fast, and cost-effective approach that measures cancer cell metabolism and their response to anticancer drugs in real time. Using a Light Addressable Potentiometric Sensor integrated with pH sensitive hydrogel nanofibers (NF-LAPS), we detect localized changes in pH of the media as cancer cells consume glucose and release lactate. NF-LAPS shows a sensitivity response of 74 mV/pH for cancer cells. Cancer cells (MDA MB231) showed a response of ∼0.4 unit change in pH compared to virtually no change observed for normal cells (MCF10A)...
January 27, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28721014/determining-optimal-dosing-regimen-of-oral-administration-of-dicloxacillin-using-monte-carlo-simulation
#10
Wei Yu, Jinru Ji, Tingting Xiao, Chaoqun Ying, Jiaheng Fang, Ping Shen, Yonghong Xiao
BACKGROUND: Dicloxacillin, a semisynthetic isoxazolyl penicillin, exhibits antimicrobial activity against a wide variety of Gram-positive bacteria, as well as stability against penicillinases and low level of toxicity. The objective of this study was to obtain optimal dosing regimen of oral administration of dicloxacillin by analyzing the pharmacokinetic (PK) index in healthy volunteers and in vitro antibacterial activity by using Monte Carlo simulation. MATERIALS AND METHODS: A total of 867 clinical isolates from community-onset infections were collected from 31 secondary hospitals in People's Republic of China...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28718949/high-dosage-of-vitamin-d-regulates-the-energy-metabolism-and-increases-insulin-sensitivity-but-are-associated-with-high-levels-of-kidney-damage
#11
Rafael Calais Gaspar, José Diego Botezelli, Gabriel Keine Kuga, Vitor Rosetto Muñoz, Andressa Coope, Rodrigo Martins Pereira, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, Leandro Pereira de Moura, Eduardo Rochete Ropelle, José Rodrigo Pauli
Preclinical Research Metabolic disorders are responsible for more than 60% of all deaths worldwide. Calcitriol or vitamin D (vitD) deficiency is associated with a large proportion of these diseases is an important therapeutic target for exploration. This study evaluated the administration of high doses of vitD (3000 IU/kg) in obese and insulin-resistant C57BL/6J mice. Our results demonstrated that although high doses of vitD provided metabolic benefits such as increased insulin sensitivity and decreased body mass, this was associated with significant damage in the kidneys of obese mice...
July 18, 2017: Drug Development Research
https://www.readbyqxmd.com/read/28707536/radiation-dose-reduction-in-multi-detector-ct-in-fracture-evaluation
#12
Jung Woo Yi, Hee Jin Park, So Yeon Lee, Myung Ho Rho, Hyun Pyo Hong, Yoon Jung Choi, Mi Sung Kim
OBJECTIVE: To evaluate whether multi-detector CT with low-dose radiation (low-dose CT) of joints can be useful when evaluating fractures. METHODS AND MATERIALS: Our study included CT scans of 398 patients, 103 shoulder cases, 109 wrist cases, 98 pelvis cases and 88 ankle cases. There were 191 women and 207 men. The low-dose CTs were performed using identical voltage and parameters with the exception of decreased (half of standard dose) tube current. Lowdose and standard-dose images were compared with regards to objective image quality, subjective evaluation of image quality and diagnostic performance for the fractures...
July 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28706134/heparin-antagonizes-cisplatin-resistance-of-a2780-ovarian-cancer-cells-by-affecting-the-wnt-signaling-pathway
#13
Daniel Bastian Pfankuchen, Fabian Baltes, Tahira Batool, Jin-Ping Li, Martin Schlesinger, Gerd Bendas
Low molecular weight heparin (LMWH), the guideline based drug for prophylaxis and treatment of cancer-associated thrombosis, was recently shown to sensitize cisplatin resistant A2780cis human ovarian cancer cells for cisplatin cytotoxicity upon 24 h pretreatment with 50 μg × mL-1 of the LMWH tinzaparin in vitro, equivalent to a therapeutic dosage. Thereby, LMWH induced sensitization by transcriptional reprogramming of A2780cis cells via not yet elucidated mechanisms that depend on cellular proteoglycans. Here we aim to illuminate the underlying molecular mechanisms of LMWH in sensitizing A2780cis cells for cisplatin...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28701167/a-combined-experimental-and-numerical-study-on-upper-airway-dosimetry-of-inhaled-nanoparticles-from-an-electrical-discharge-machine-shop
#14
Lin Tian, Yidan Shang, Rui Chen, Ru Bai, Chunying Chen, Kiao Inthavong, Jiyuan Tu
BACKGROUNDS: Exposure to nanoparticles in the workplace is a health concern to occupational workers with increased risk of developing respiratory, cardiovascular, and neurological disorders. Based on animal inhalation study and human lung tumor risk extrapolation, current authoritative recommendations on exposure limits are either on total mass or number concentrations. Effects of particle size distribution and the implication to regional airway dosages are not elaborated. METHODS: Real time production of particle concentration and size distribution in the range from 5...
July 12, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28696828/small-molecule-inhibitor-tw-37-is-tolerable-and-synergistic-with-chemotherapy-in-nasopharyngeal-carcinoma
#15
Ying Lu, Haixin Huang, Hui Yang, Dagui Chen, Sibei Wu, Zhou Jiang, Rensheng Wang
Chemotherapy is a crucial adjuvant therapy of advanced nasopharyngeal carcinoma (NPC). However, enhancing sensitivity and tolerance of chemotherapeutics in NPC treatment have been challenging. Both Bcl-2 and Mcl-1, 2 pro-survival proteins of Bcl-2 family, play essential roles on the chemotherapy tolerance of numerous cancers. In the present study, we explored the influences of TW-37, a small molecule inhibitor of Bcl-2 and Mcl-1, on the efficiency of chemotherapy for NPC. Oncomine cancer database shows that NPC tissues have higher expression of Bcl-2 and Mcl-1 than those of normal nasopharyngeal epithelial (NPE) tissues...
July 11, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28692743/a-flexible-multivariate-random-effects-proportional-odds-model-with-application-to-adverse-effects-during-radiation-therapy
#16
Nicole H Augustin, Sung Won Kim, Annemarie Uhlig, Christina Hanser, Michael Henke, Martin Schumacher
Radiation therapy in patients with head and neck cancer has a toxic effect on mucosa, the soft tissue in and around the mouth. Hence mucositis is a serious common side effect and is a condition characterized by pain and inflammation of the surface of the mucosa. Although the mucosa recovers during breaks of and following the radiotherapy course, the recovery will depend on the type of tissue involved and on its location. We present a novel flexible multivariate random effects proportional odds model that takes account of the longitudinal course of oral mucositis at different mouth sites and of the radiation dosage (in terms of cumulative dose)...
July 10, 2017: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/28690966/carbon-nanomaterials-sensitize-prostate-cancer-cells-to-docetaxel-and-mitomycin-c-via-induction-of-apoptosis-and-inhibition-of-proliferation
#17
Kati Erdmann, Jessica Ringel, Silke Hampel, Manfred P Wirth, Susanne Fuessel
We have previously shown that carbon nanofibers (CNFs) and carbon nanotubes (CNTs) can sensitize prostate cancer (PCa) cells to platinum-based chemotherapeutics. In order to further verify this concept and to avoid a bias, the present study investigates the chemosensitizing potential of CNFs and CNTs to the conventional chemotherapeutics docetaxel (DTX) and mitomycin C (MMC), which have different molecular structures and mechanisms of action than platinum-based chemotherapeutics. DU-145 PCa cells were treated with DTX and MMC alone or in combination with the carbon nanomaterials...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28670298/in-vitro-differentiation-of-preosteoblast-like-cells-mc3t3-e1-to-adipocytes-is-enhanced-by-1-25-oh-2-vitamin-d3
#18
Elisha Pendleton, Nalini Chandar
Osteoblasts and adipocytes originate from common mesenchymal progenitor cells and are controlled by specific transcription factors. While 1,25-dihydroxyvitamin D3 (vitamin D) is known to be an important factor for osteoblast differentiation, there are conflicting reports regarding its effect on adipogenesis. In this study, we attempted to understand the effect of exposure of preosteoblasts (MC3T3-E1) to adipogenic media with and without vitamin D and determined the expression of adipogenic genes during this process...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28667899/sensitivity-to-antitubulin-chemotherapeutics-is-potentiated-by-a-photoactivable-nanoliposome
#19
Xiaobing Wang, Xiufang Liu, Yixiang Li, Pan Wang, Xiaolan Feng, Quanhong Liu, Fei Yan, Hairong Zheng
Anti-microtubule therapy represents one of the most strategic cancer therapeutics. Tublin inhibitor such as paclitaxel (PTX) is well known to disturb the dynamic nature of microtubules, being considered as the first-line drug for various malignancies. However, PTX does not show favorable clinical outcomes due to serious systemic toxicities and low selectivity. The development of PTX delivery systems and combinational therapies has been conducted to enhance PTX efficacy with poorly defined mechanisms. Herein, we introduced a reactive oxygen species producible composite liposome based on a new photosensitizer sinoporphyrin sodium (DVDMS) to enhance the therapeutic effect of PTX through photochemical stimulation, and more importantly, the pivotal molecular regulation mechanisms were specifically explored...
June 23, 2017: Biomaterials
https://www.readbyqxmd.com/read/28666362/inference-of-causative-genes-for-alzheimer-s-disease-due-to-dosage-imbalance
#20
Mizuka Sekine, Takashi Makino
Copy number variations (CNVs) have recently drawn attention as an important genetic factor for diseases, especially common neuropsychiatric disorders including Alzheimer's disease (AD). Because most of the pathogenic CNV regions overlap with multiple genes, it has been challenging to identify the true disease-causing genes amongst them. Notably, a recent study reported that CNV regions containing ohnologs, which are dosage-sensitive genes, are likely to be deleterious. Utilizing the unique feature of ohnologs could be useful for identifying causative genes with pathogenic CNVs, however its effectiveness is still unclear...
June 27, 2017: Molecular Biology and Evolution
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