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resident memory t cells

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https://www.readbyqxmd.com/read/29912035/bone-marrow-derived-cd8-t-cells-from-pediatric-leukemia-patients-express-pd1-and-expand-ex-vivo-following-induction-chemotherapy
#1
Katie Palen, Monica Thakar, Bryon D Johnson, Jill A Gershan
Adoptive cell therapy (ACT) of chimeric antigen receptor T cells has demonstrated remarkable success for the treatment of pediatric B-cell leukemia. For patients who are not candidates for chimeric antigen receptor T-cell therapy, ACT using tumor antigen-experienced polyclonal T cells may be a treatment option. Since leukemic blasts reside in the bone marrow and bone marrow is a preferred site for homeostatic proliferation of cytotoxic memory CD8 T cells, we hypothesized that bone marrow would be a source of activated T cells...
June 14, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29911996/altered-immune-cell-follicular-dynamics-in-hiv-infection-following-influenza-vaccination
#2
Eirini Moysi, Suresh Pallikkuth, Leslie R De Armas, Louis E Gonzalez, David Ambrozak, Varghese George, David Huddleston, Rajendra Pahwa, Richard A Koup, Constantinos Petrovas, Savita Pahwa
HIV infection changes the lymph node (LN) tissue architecture, potentially impairing the immunologic response to antigenic challenge. The tissue-resident immune cell dynamics in virologically suppressed HIV+ patients on combination antiretroviral therapy (cART) are not clear. We obtained LN biopsies before and 10 to 14 days after trivalent seasonal influenza immunization from healthy controls (HCs) and HIV+ volunteers on cART to investigate CD4+ T follicular helper (Tfh) and B cell dynamics by flow cytometry and quantitative imaging analysis...
June 18, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29907691/a-recessive-form-of-hyper-ige-syndrome-by-disruption-of-znf341-dependent-stat3-transcription-and-activity
#3
Vivien Béziat, Juan Li, Jian-Xin Lin, Cindy S Ma, Peng Li, Aziz Bousfiha, Isabelle Pellier, Samaneh Zoghi, Safa Baris, Sevgi Keles, Paul Gray, Ning Du, Yi Wang, Yoann Zerbib, Romain Lévy, Thibaut Leclercq, Frédégonde About, Ai Ing Lim, Geetha Rao, Kathryn Payne, Simon J Pelham, Danielle T Avery, Elissa K Deenick, Bethany Pillay, Janet Chou, Romain Guery, Aziz Belkadi, Antoine Guérin, Mélanie Migaud, Vimel Rattina, Fatima Ailal, Ibtihal Benhsaien, Matthieu Bouaziz, Tanwir Habib, Damien Chaussabel, Nico Marr, Jamel El-Benna, Bodo Grimbacher, Orli Wargon, Jacinta Bustamante, Bertrand Boisson, Ingrid Müller-Fleckenstein, Bernhard Fleckenstein, Marie-Olivia Chandesris, Matthias Titeux, Sylvie Fraitag, Marie-Alexandra Alyanakian, Marianne Leruez-Ville, Capucine Picard, Isabelle Meyts, James P Di Santo, Alain Hovnanian, Ayper Somer, Ahmet Ozen, Nima Rezaei, Talal A Chatila, Laurent Abel, Warren J Leonard, Stuart G Tangye, Anne Puel, Jean-Laurent Casanova
Heterozygosity for human signal transducer and activator of transcription 3 ( STAT3 ) dominant-negative (DN) mutations underlies an autosomal dominant form of hyper-immunoglobulin E syndrome (HIES). We describe patients with an autosomal recessive form of HIES due to loss-of-function mutations of a previously uncharacterized gene, ZNF341 ZNF341 is a transcription factor that resides in the nucleus, where it binds a specific DNA motif present in various genes, including the STAT3 promoter. The patients' cells have low basal levels of STAT3 mRNA and protein...
June 15, 2018: Science Immunology
https://www.readbyqxmd.com/read/29904388/niches-for-the-long-term-maintenance-of-tissue-resident-memory-t-cells
#4
REVIEW
Shiki Takamura
Tissue-resident memory T cells (TRM cells) are a population of immune cells that reside in the lymphoid and non-lymphoid organs without recirculation through the blood. These important cells occupy and utilize unique anatomical and physiological niches that are distinct from those for other memory T cell populations, such as central memory T cells in the secondary lymphoid organs and effector memory T cells that circulate through the tissues. CD8+ TRM cells typically localize in the epithelial layers of barrier tissues where they are optimally positioned to act as sentinels to trigger antigen-specific protection against reinfection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29900173/a-perspective-on-the-interplay-of-ultraviolet-radiation-skin-microbiome-and-skin-resident-memory-tcr%C3%AE-%C3%AE-cells
#5
VijayKumar Patra, Léo Laoubi, Jean-François Nicolas, Marc Vocanson, Peter Wolf
The human skin is known to be inhabited by diverse microbes, including bacteria, fungi, viruses, archaea, and mites. This microbiome exerts a protective role against infections by promoting immune development and inhibiting pathogenic microbes to colonize skin. One of the factors having an intense effect on the skin and its resident microbes is ultraviolet-radiation (UV-R). UV-R can promote or inhibit the growth of microbes on the skin and modulate the immune system which can be either favorable or harmful...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29900048/vaccination-induced-skin-resident-memory-cd8-t-cells-mediate-strong-protection-against-cutaneous-melanoma
#6
Felipe Gálvez-Cancino, Ernesto López, Evelyn Menares, Ximena Díaz, Camila Flores, Pablo Cáceres, Sofía Hidalgo, Ornella Chovar, Marcela Alcántara-Hernández, Vincenzo Borgna, Manuel Varas-Godoy, Flavio Salazar-Onfray, Juliana Idoyaga, Alvaro Lladser
Memory CD8+ T cell responses have the potential to mediate long-lasting protection against cancers. Resident memory CD8+ T (Trm) cells stably reside in non-lymphoid tissues and mediate superior innate and adaptive immunity against pathogens. Emerging evidence indicates that Trm cells develop in human solid cancers and play a key role in controlling tumor growth. However, the specific contribution of Trm cells to anti-tumor immunity is incompletely understood. Moreover, clinically applicable vaccination strategies that efficiently establish Trm cell responses remain largely unexplored and are expected to strongly protect against tumors...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29895956/lymph-node-%C3%AE-%C3%AE-and-%C3%AE-%C3%AE-cd8-t-cells-share-migratory-properties
#7
Milas Ugur, Anne Kaminski, Oliver Pabst
During immune responses, T cells differentiate into subsets with different functions and migratory properties. Here we characterize migratory behavior of endogenous αβ CD8+ and γδ T cells in lymph nodes by long-term tracking following in vivo photoconversion. We identified subsets of γδ T cells with distinct circulation kinetics that closely mirrored migratory subsets of αβ CD8+ T cells. Notably, αβ CD8+ and γδ T cells both comprised resident populations which stayed in lymph nodes for 4 weeks without circulation or proliferation...
June 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29892289/varying-immunizations-with-plasmodium-radiation-attenuated-sporozoites-alter-tissue-specific-cd8-t-cell-dynamics
#8
Roland Frank, Michael Gabel, Kirsten Heiss, Ann-Kristin Mueller, Frederik Graw
Whole sporozoite vaccines represent one of the most promising strategies to induce protection against malaria. However, the development of efficient vaccination protocols still remains a major challenge. To understand how the generation of immunity is affected by variations in vaccination dosage and frequency, we systematically analyzed intrasplenic and intrahepatic CD8+ T cell responses following varied immunizations of mice with radiation-attenuated sporozoites. By combining experimental data and mathematical modeling, our analysis indicates a reversing role of spleen and liver in the generation of protective liver-resident CD8+ T cells during priming and booster injections: While the spleen acts as a critical source compartment during priming, the increase in vaccine-induced hepatic T cell levels is likely due to local reactivation in the liver in response to subsequent booster injections...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29891791/tgf-%C3%AE-in-t-cell-biology-implications-for-cancer-immunotherapy
#9
REVIEW
Amina Dahmani, Jean-Sébastien Delisle
Transforming Growth Factor beta (TGF-β) is a pleiotropic cytokine produced in large amounts within cancer microenvironments that will ultimately promote neoplastic progression, notably by suppressing the host’s T-cell immunosurveillance. This effect is mostly due to the well-known inhibitory effect of TGF-β on T cell proliferation, activation, and effector functions. Moreover, TGF-β subverts T cell immunity by favoring regulatory T-cell differentiation, further reinforcing immunosuppression within tumor microenvironments...
June 11, 2018: Cancers
https://www.readbyqxmd.com/read/29875151/cutting-edge-evidence-for-nonvascular-route-of-visceral-organ-immunosurveillance-by-t-cells
#10
Elizabeth M Steinert, Emily A Thompson, Lalit K Beura, Omar A Adam, Jason S Mitchell, Mengdi Guo, Elise R Breed, Frances V Sjaastad, Vaiva Vezys, David Masopust
Lymphocytes enter tissues from blood vessels through a well-characterized three-step process of extravasation. To our knowledge, nonvascular routes of lymphocyte entry have not been described. In this article, we report that Ag-experienced CD8 T cells in mice recirculate from blood through the peritoneal cavity. In the event of infection, Ag-experienced CD8 T cell subsets adhered to visceral organs, indicating potential transcapsular immunosurveillance. Focusing on the male genital tract (MGT), we observed Ag-experienced CD8 T cell migration from the peritoneal cavity directly to the infected MGT across the capsule, which was dependent on the extracellular matrix receptor CD44...
June 6, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29873694/the-compartmentalized-inflammatory-response-in-the-multiple-sclerosis-brain-is-composed-of-tissue-resident-cd8-t-lymphocytes-and-b-cells
#11
Joana Machado-Santos, Etsuji Saji, Anna R Tröscher, Manuela Paunovic, Roland Liblau, Galina Gabriely, Christian G Bien, Jan Bauer, Hans Lassmann
Multiple sclerosis is an inflammatory demyelinating disease in which active demyelination and neurodegeneration are associated with lymphocyte infiltrates in the brain. However, so far little is known regarding the phenotype and function of these infiltrating lymphocyte populations. In this study, we performed an in-depth phenotypic characterization of T and B cell infiltrates in a large set of multiple sclerosis cases with different disease and lesion stages and compared the findings with those seen in inflammatory, non-inflammatory and normal human controls...
June 4, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29858287/resident-t-cells-stand-up-to-hiv
#12
REVIEW
Nadia R Roan
HIV-specific resident memory T cells are abundant in lymphoid tissues of elite controllers and exhibit distinct functional properties.
June 1, 2018: Science Immunology
https://www.readbyqxmd.com/read/29858286/identification-and-characterization-of-hiv-specific-resident-memory-cd8-t-cells-in-human-lymphoid-tissue
#13
Marcus Buggert, Son Nguyen, Gonzalo Salgado-Montes de Oca, Bertram Bengsch, Samuel Darko, Amy Ransier, Emily R Roberts, Daniel Del Alcazar, Irene Bukh Brody, Laura A Vella, Lalit Beura, Sathi Wijeyesinghe, Ramin S Herati, Perla M Del Rio Estrada, Yuria Ablanedo-Terrazas, Leticia Kuri-Cervantes, Alberto Sada Japp, Sasikanth Manne, Shant Vartanian, Austin Huffman, Johan K Sandberg, Emma Gostick, Gregory Nadolski, Guido Silvestri, David H Canaday, David A Price, Constantinos Petrovas, Laura F Su, Golnaz Vahedi, Yoav Dori, Ian Frank, Maxim G Itkin, E John Wherry, Steven G Deeks, Ali Naji, Gustavo Reyes-Terán, David Masopust, Daniel C Douek, Michael R Betts
Current paradigms of CD8+ T cell-mediated protection in HIV infection center almost exclusively on studies of peripheral blood, which is thought to provide a window into immune activity at the predominant sites of viral replication in lymphoid tissues (LTs). Through extensive comparison of blood, thoracic duct lymph (TDL), and LTs in different species, we show that many LT memory CD8+ T cells bear phenotypic, transcriptional, and epigenetic signatures of resident memory T cells (TRMs ). Unlike their circulating counterparts in blood or TDL, most of the total and follicular HIV-specific CD8+ T cells in LTs also resemble TRMs Moreover, high frequencies of HIV-specific CD8+ TRMs with skewed clonotypic profiles relative to matched blood samples are present in LTs of individuals who spontaneously control HIV replication in the absence of antiretroviral therapy (elite controllers)...
June 1, 2018: Science Immunology
https://www.readbyqxmd.com/read/29852019/cytomegalovirus-establishes-a-latent-reservoir-and-triggers-long-lasting-inflammation-in-the-eye
#14
Valentina Voigt, Christopher E Andoniou, Iona S Schuster, Anna Oszmiana, Monique L Ong, Peter Fleming, John V Forrester, Mariapia A Degli-Esposti
Recent outbreaks of Ebola and Zika have highlighted the possibility that viruses may cause enduring infections in tissues like the eye, including the neural retina, which have been considered immune privileged. Whether this is a peculiarity of exotic viruses remains unclear, since the impact of more common viral infections on neural compartments has not been examined, especially in immunocompetent hosts. Cytomegalovirus is a common, universally distributed pathogen, generally innocuous in healthy individuals...
May 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29848753/developmental-regulation-of-effector-and-resident-memory-t-cell-generation-during-pediatric-viral-respiratory-tract-infection
#15
Thomas J Connors, J Scott Baird, Margot C Yopes, Kyra D Zens, Kalpana Pethe, Thyyar M Ravindranath, Siu-Hong Ho, Donna L Farber
Viral respiratory tract infections (VRTI) remain a leading cause of morbidity and mortality among infants and young children. In mice, optimal protection to VRTI is mediated by recruitment of effector T cells to the lungs and respiratory tract, and subsequent establishment of tissue resident memory T cells (Trm), which provide long-term protection. These critical processes of T cell recruitment to the respiratory tract, their role in disease pathogenesis, and establishment of local protective immunity remain undefined in pediatric VRTI...
May 30, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29790576/memory-t-cell-subsets-in-healthy-gingiva-and-periodontitis-tissues
#16
Rangsini Mahanonda, Chantrakorn Champaiboon, Keskanya Subbalekha, Noppadol Sa-Ard-Iam, Arsarn Yongyuth, Benjarat Isaraphithakkul, Pimprapa Rerkyen, Orawan Charatkulangkun, Sathit Pichyangkul
BACKGROUND: In the gingival sulcus, effective and balanced innate and adaptive immune responses against subgingival plaque microbiome are crucial to maintain immune homeostasis. In this study, we investigated the memory T cell subsets in healthy gingiva and periodontitis tissues. METHODS: Anatomical localization of T cells (CD3+ , CD4+ , and CD8+ ) in healthy gingiva and periodontitis tissues were examined immunohistochemically. Subsets of memory T cells from isolated gingival cells were analyzed by flow cytometry using a cocktail of monoclonal antibodies (anti-CD69, anti-CD103, anti-CD45RA, anti-CCR7, anti-CD28, and anti-CD95)...
May 23, 2018: Journal of Periodontology
https://www.readbyqxmd.com/read/29777219/tissue-resident-memory-t-cells-at-the-center-of-immunity-to-solid-tumors
#17
REVIEW
Derk Amsen, Klaas P J M van Gisbergen, Pleun Hombrink, Rene A W van Lier
Immune responses in tissues are constrained by the physiological properties of the tissue involved. Tissue-resident memory T cells (TRM cells) are a recently discovered lineage of T cells specialized for life and function within tissues. Emerging evidence has shown that TRM cells have a special role in the control of solid tumors. A high frequency of TRM cells in tumors correlates with favorable disease progression in patients with cancer, and studies of mice have shown that TRM cells are necessary for optimal immunological control of solid tumors...
May 18, 2018: Nature Immunology
https://www.readbyqxmd.com/read/29758330/human-liver-infiltrating-%C3%AE-%C3%AE-t-cells-are-composed-of-clonally-expanded-circulating-and-tissue-resident-populations
#18
Stuart Hunter, Carrie Willcox, Martin Davey, Sofya Kasatskaya, Hannah Jeffery, Dmitriy Chudakov, Ye Oo, Benjamin Willcox
BACKGROUND & AIM: γδ T-cells comprise a substantial proportion of tissue-associated lymphocytes. However, our current understanding of human γδ T-cells is primarily based on peripheral blood subsets, while the immunobiology of tissue-associated subsets remains largely unclear. METHODS: To address this, we characterised the TCR diversity, immunophenotype and function of human liver infiltrating γδ T-cells, focussing on the predominant tissue-associated Vδ2neg γδ subset, which is implicated in liver immunopathology...
May 11, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29749428/accumulation-of-cd69-tissue%C3%A2-resident-memory-t-cells-in-the-nasal-polyps-of-patients-with-chronic-rhinosinusitis
#19
Pascal Ickrath, Norbert Kleinsasser, Xin Ding, Christian Ginzkey, Niklas Beyersdorf, Rudolf Hagen, Thomas Kerkau, Stephan Hackenberg
In patients with chronic rhinosinusitis with nasal polyps (CRSwNP), a relative accumulation of cluster of differentiation (CD)8+ T cells over CD4+ T cells occurs in nasal polyps compared with the peripheral blood. Nasal CD8+ T cells and CD4+ T cells predominantly present an effector memory phenotype. Immunological studies have reported that memory T cells recirculate from the tissues to the peripheral blood and a high percentage of these T cells persist within the tissue. The aim of the present study was to characterize CD69+ sphingosine‑1‑phosphate receptor 1 (S1PR1)‑ tissue resident memory T cells (Trm) in the polyps of patients with CRSwNP...
August 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29743372/-breadth-and-functionality-of-varicella-zoster-virus-glycoprotein-specific-antibodies-identified-after-zostavax-vaccination-in-humans
#20
Nicole L Sullivan, Morgan A Reuter-Monslow, Janet Sei, Eberhard Durr, Carl W Davis, Cathy Chang, Megan McCausland, Andreas Wieland, David Krah, Nadine Rouphael, Aneesh K Mehta, Mark J Mulligan, Bali Pulendran, Rafi Ahmed, Kalpit A Vora
Herpes zoster (HZ/shingles) is the clinical manifestation of varicella zoster virus (VZV) reactivation. HZ typically develops as people age due to decreased cell-mediated immunity. However, the importance of antibodies for immunity against HZ prevention remains to be understood. The goal of this study was to examine the breadth and functionality of VZV-specific antibodies after vaccination with a live attenuated HZ vaccine (Zostavax). Direct enumeration of VZV-specific antibody secreting cells (ASC) via ELISPOT showed that Zostavax can induce both IgG and IgA ASCs seven days after vaccination, but not IgM ASCs...
May 9, 2018: Journal of Virology
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