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breast cancer, circulating tumor cells

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https://www.readbyqxmd.com/read/28734227/continuous-delivery-of-neutralizing-antibodies-elevate-ccl2-levels-in-mice-bearing-mcf10ca1d-breast-tumor-xenografts
#1
Min Yao, Curtis Smart, Qingting Hu, Nikki Cheng
Chemokines are small soluble molecules that play critical roles in wound healing, infection, and cancer progression. In particular, overexpression of the C-C motif chemokine ligand 2 (CCL2) in multiple cancer types correlates with poor patient prognosis. Animal studies have shown that CCL2 signals to macrophages and breast cancer cells to promote tumor growth, invasion, and metastasis, indicating that CCL2 is a promising therapeutic target. However, the effectiveness of human-specific neutralizing antibodies has not been fully evaluated...
July 19, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28725898/the-effect-of-selected-food-phytochemicals-on-breast-cancer-metastasis-based-on-in-vivo-capture-of-circulating-tumor-cells
#2
Chuanchen Wu, Zhaochen Liu, Zhen Zhang, Yuehua Jiang, Hongyan Zhang
The number of circulating tumor cells (CTCs) in a mouse tumor model fed with different dietary factors was first evaluated by in vivo CTC capture at different time points of cancer progression. The results showed that the number of CTCs reflected the degree of cancer progression. A new assessment method of dietary factor effects on cancer metastasis was established.
July 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28725276/early-stage-breast-cancer-treatment-and-prognostic-factors-post-san-antonio-breast-cancer-symposium-2016
#3
REVIEW
Christoph Suppan, Marija Balic
Developments in early breast cancer presented at the 2016 San Antonio Breast Cancer Symposium included important studies on extending adjuvant endocrine therapy with aromatase inhibitors, the role of bisphosphonates, and evidence for molecular prognostic factors and circulating tumor cells in early stage breast cancer patients.
2017: Memo
https://www.readbyqxmd.com/read/28720217/body-mass-index-mediates-the-prognostic-significance-of-circulating-tumor-cells-in-inflammatory-breast-cancer
#4
Oluwadamilola M Fayanju, Carolyn S Hall, Jessica Bowman Bauldry, Mandar Karhade, Lily M Valad, Henry M Kuerer, Sarah M DeSnyder, Carlos H Barcenas, Anthony Lucci
BACKGROUND: Obesity (BMI≥30) may be an etiologic and prognostic factor in inflammatory breast cancer (IBC). We examined the relationship between BMI, pathologic complete response (pCR), and circulating-tumor-cell (CTC) levels in IBC. METHODS: Cohort included IBC patients diagnosed 2005-2015 who had neoadjuvant chemotherapy during a prospective trial on CTCs and pathologic review describing pCR. Chi-square, logistic regression, and Cox proportional hazards models were used to identify clinicopathologic associations with event-free survival (EFS)...
June 23, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28700115/lkb1-pro-oncogenic-activity-triggers-cell-survival-in-circulating-tumor-cells
#5
Elisabeth Katharina Trapp, Leonie Majunke, Beate Zill, Harald Sommer, Ulrich Andergassen, Julian Koch, Nadia Harbeck, Sven Mahner, Thomas Wolfram Paul Friedl, Wolfgang Janni, Brigitte Rack, Marianna Alunni-Fabbroni
During intravasation, circulating tumor cells (CTCs) detach from the epithelium of origin and begin the Epithelial-to Mesenchymal-Transition (EMT) process, where they lose epithelial features and pass through the endothelium to enter circulation. Although detachment from the extracellular matrix is a strong source of metabolic stress, which induces anoikis, CTCs can survive. Recently, the tumor suppressor liver kinase B1 (LKB1) has gained attention for its role as a proto-oncogene in restoring the correct ATP/AMP ratio during metabolic stress...
July 12, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28687903/prognostic-values-of-cancer-associated-macrophage-like-cells-caml-enumeration-in-metastatic-breast-cancer
#6
Zhaomei Mu, Chun Wang, Zhong Ye, Giovanna Rossi, Carl Sun, Ling Li, Zhu Zhu, Hushan Yang, Massimo Cristofanilli
PURPOSE: Circulating cancer associated macrophage-like cells (CAMLs) have been detected in the peripheral blood of patients with solid tumors including breast cancer. However, the prognostic relevance of CAMLs in metastatic breast cancer (MBC) has not been evaluated. In the present study, we aimed to measure CAMLs and circulating tumor cells (CTCs) at baseline and examine their prognostic value in patients with MBC. METHODS: Peripheral blood samples from 127 MBC patients were collected at baseline before starting a new treatment...
July 7, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28686704/chemosensitizing-indomethacin-conjugated-dextran-based-micelles-for-effective-delivery-of-paclitaxel-in-resistant-breast-cancer-therapy
#7
Weiping Ji, Bo Wang, Qiuping Fan, Chao Xu, Youwu He, Youfen Chen
Multidrug resistance (MDR) against chemotherapeutic agents has become the major obstacle to successful cancer therapy and multidrug resistance-associated proteins (MRPs) mediated drug efflux is the key factor for MDR. Indomethacin (IND), one of the non-steroidal anti-inflammatory agents, has been demonstrated to increase cytotoxic effects of anti-tumor agents as MRP substrates. In this study, dextran-g-indomethacin (DEX-IND) polymeric micelles were designed to delivery paclitaxel (PTX) for the treatment of MDR tumors...
2017: PloS One
https://www.readbyqxmd.com/read/28680538/a-tumor-specific-antibody-to-aid-breast-cancer-screening-in-women-with-dense-breast-tissue
#8
Lopamudra Das Roy, Lloye M Dillon, Ru Zhou, Laura J Moore, Chad Livasy, Joe M El-Khoury, Rahul Puri, Pinku Mukherjee
Screening for breast cancer has predominantly been done using mammography. Unfortunately, mammograms miss 50% cancers in women with dense breast tissue. Multi-modal screenings offer the best chance of enhancing breast cancer screening effectiveness. We evaluated the use of TAB004, an antibody that recognizes the tumor form of the glycoprotein MUC1 (tMUC1), to aid early detection of breast cancer. Our experimental approach was to follow tMUC1 from the tissue into circulation. We found that 95% of human breast cancer tissues across all subtypes stained positive for TAB004...
March 2017: Genes & Cancer
https://www.readbyqxmd.com/read/28679775/detection-of-activating-estrogen-receptor-gene-esr1-mutations-in-single-circulating-tumor-cells
#9
Carmela Paolillo, Zhaomei Mu, Giovanna Rossi, Matthew J Schiewer, Thomas Nguyen, Laura Austin, Ettore Capoluongo, Karen E Knudsen, Massimo Cristofanilli, Paolo Fortina
Early detection is essential for treatment plans before onset of metastatic disease. Our purpose was to demonstrate feasibility to detect and monitor estrogen receptor 1 (ESR1) gene mutations at the single circulating tumor cell (CTC) level in metastatic breast cancer (MBC). <br /><br />Experimental Design: We used a CTC molecular characterization approach to investigate heterogeneity of 14 hot spot mutations in ESR1 and their correlation with endocrine resistance. Combining the CellSearch(®) and DEPArray™ technologies allowed recovery of 71 single CTCs and 12 WBC from 3 ER-positive MBC patients...
July 5, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28679772/prognostic-impact-of-circulating-tumor-cells-for-breast-cancer-patients-treated-in-the-neoadjuvant-geparquattro-trial
#10
Sabine Riethdorf, Volkmar Müller, Sibylle Loibl, Valentina Nekljudova, Karsten Weber, Jens Huober, Tanja Fehm, Iris Schrader, Jorn Hilfrich, Frank Holms, Hans Tesch, Christian Schem, Gunter von Minckwitz, Michael Untch, Klaus Pantel
This study aimed to evaluate the prognostic impact of circulating tumor cells (CTCs) detected in patients with operable or locally advanced breast cancer before and after neoadjuvant therapy (NT) within the clinical trial GeparQuattro.<br />Experimental Design: Data on CTCs enumerated with the CellSearch™ system were available for 213 and 207 patients before and after NT, respectively. Associations of CTCs with disease-free (DFS) and overall survival (OS) were analyzed by non-parametric Kaplan-Meier estimates and parametric Cox regression...
July 5, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28672799/exosomal-micrornas-in-breast-cancer-towards-diagnostic-and-therapeutic-applications
#11
REVIEW
Lorenzo F Sempere, Jessica Keto, Muller Fabbri
Soon after the discovery of microRNAs over 15 years ago, a myriad of research groups around the world sought to develop clinical applications in breast cancer for these short, noncoding, regulatory RNAs. While little of this knowledge has translated into the clinic, the recent research explosion on cell-to-cell communication via exosomes and other extracellular vesicles has rekindled interest in microRNA-based clinical applications. microRNAs appear to be a preferential and important cargo of exosomes in mediating biological effects in recipient cells...
June 24, 2017: Cancers
https://www.readbyqxmd.com/read/28670371/circulating-tumor-cells-what-we-know-what-do-we-want-to-know-about-them-and-are-they-ready-to-be-used-in-clinics
#12
Zuzana Bielčiková, Anna Jakabová, Michael Pinkas, Milada Zemanová, Katarína Kološtová, Vladimír Bobek
Circulating tumor cells (CTC) present in peripheral blood are assigned precursors of advanced tumor disease. Simplicity of blood withdrawal procedure adds practically an unlimited possibility of the CTC-monitoring and the advantages of the repeated biopsies over time. CTC got prognostic, predictive and diagnostic status with the technologic advance. Although the clinical utility of CTC has reached the high evidence, the significance of CTC testing was presented in the treatment strategy mostly with palliative intention...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28649661/inflammatory-breast-cancer-a-model-for-investigating-cluster-based-dissemination
#13
Mohit Kumar Jolly, Marcelo Boareto, Bisrat G Debeb, Nicola Aceto, Mary C Farach-Carson, Wendy A Woodward, Herbert Levine
Metastases claim more than 90% of cancer-related patient deaths and are usually seeded by a subset of circulating tumor cells shed off from the primary tumor. In circulation, circulating tumor cells are found both as single cells and as clusters of cells. The clusters of circulating tumor cells, although many fewer in number, possess much higher metastatic potential as compared to that of individual circulating tumor cells. In this review, we highlight recent insights into molecular mechanisms that can enable the formation of these clusters-(a) hybrid epithelial/mesenchymal phenotype of cells that couples their ability to migrate and adhere, and (b) intercellular communication that can spatially coordinate the cluster formation and provide survival signals to cancer cells...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28648008/-circulating-tumor-cells-in-patients-with-breast-tumors-were-detected-by-a-novel-device-a-multicenter-clinical-trial-in-china
#14
J B Li, C Z Geng, M Yan, Y S Wang, Q C Ouyang, Y M Yin, L N Wu, J He, Z F Jiang
Objective: Circulating tumor cells (CTC) have become an important part of liquid biopsy, which have underwent a process from simple counting to molecular typing and genotyping. To this end, we used Cellcollector to verify the effectiveness and safety of CTC detection in patients with breast tumor, and to conduct the following analysis. Methods: One hundred and ninety patients who received treatment in six leading Chinese cancer centers were involved from April to August in 2016. Among which, 127 patients were diagnosed as metastatic breast cancer, and the other 63 patients as benign breast tumors...
June 27, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28645267/a-rapid-and-quantitative-method-to-detect-human-circulating-tumor-cells-in-a-preclinical-animal-model
#15
Shih-Hsin Tu, Yi-Chen Hsieh, Li-Chi Huang, Chun-Yu Lin, Kai-Wen Hsu, Wen-Shyang Hsieh, Wei-Ming Chi, Chia-Hwa Lee
BACKGROUND: As cancer metastasis is the deadliest aspect of cancer, causing 90% of human deaths, evaluating the molecular mechanisms underlying this process is the major interest to those in the drug development field. Both therapeutic target identification and proof-of-concept experimentation in anti-cancer drug development require appropriate animal models, such as xenograft tumor transplantation in transgenic and knockout mice. In the progression of cancer metastasis, circulating tumor cells (CTCs) are the most critical factor in determining the prognosis of cancer patients...
June 23, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28643770/role-of-circulating-tumor-cell-ctc-monitoring-in-evaluating-prognosis-of-triple-negative-breast-cancer-patients-in-china
#16
Yanwu Zhang, Yidong Lv, Yaodong Niu, Hongge Su, Aiqiang Feng
BACKGROUND Breast cancer (BC) is the most common malignant tumor in females. This study investigated the role and utility of CTC monitoring in evaluating the prognosis of triple-negative breast cancer patients. MATERIAL AND METHODS We enrolled 286 female triple-negative breast cancer patients who were diagnosed at and received radical resection surgery in our hospital. Peripheral venous blood samples were collected preoperatively and at 3 and 7 days postoperative, and the Cell Search system was used to detect CTC in peripheral blood...
June 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28643236/multi-reservoir-phospholipid-shell-encapsulating-protamine-nanocapsules-for-co-delivery-of-letrozole-and-celecoxib-in-breast-cancer-therapy
#17
Ahmed O Elzoghby, Shaimaa K Mostafa, Maged W Helmy, Maha A ElDemellawy, Salah A Sheweita
PURPOSE: In the current work, we propose a combined delivery nanoplatform for letrozole (LTZ) and celecoxib (CXB). METHODS: Multi-reservoir nanocarriers were developed by enveloping protamine nanocapsules (PRM-NCs) within drug-phospholipid complex bilayer. RESULTS: Encapsulation of NCs within phospholipid bilayer was confirmed by both size increase from 109.7 to 179.8 nm and reduction of surface charge from +19.0 to +7.78 mV. The multi-compartmental core-shell structure enabled biphasic CXB release with initial fast release induced by complexation with phospholipid shell followed by prolonged release from oily core...
June 22, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28637482/microrna-200c-and-microrna-141-are-regulated-by-a-foxp3-kat2b-axis-and-associated-with-tumor-metastasis-in-breast-cancer
#18
Guangxin Zhang, Wei Zhang, Bingjin Li, Erica Stringer-Reasor, Chengjing Chu, Liyan Sun, Sejong Bae, Dongquan Chen, Shi Wei, Kenneth Jiao, Wei-Hsiung Yang, Ranji Cui, Runhua Liu, Lizhong Wang
BACKGROUND: Members of the microRNA (miR)-200 family, which are involved in tumor metastasis, have potential as cancer biomarkers, but their regulatory mechanisms remain elusive. METHODS: We investigated FOXP3-inducible breast cancer cells, Foxp3 heterozygous Scurfy mutant (Foxp3 (sf/+) ) female mice, and patients with breast cancer for characterization of the formation and regulation of the miR-200 family in breast cancer cells and circulation. Participants (259), including patients with breast cancer or benign breast tumors, members of breast cancer families, and healthy controls, were assessed for tumor and circulating levels of the miR-200 family...
June 21, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28634945/analysis-of-breast-cancer-cell-invasion-using-an-organotypic-culture-system
#19
Romana E Ranftl, Fernando Calvo
Metastasis is the main cause of cancer patient mortality. Local tumor invasion is a key step in metastatic dissemination whereby cancer cells dislodge from primary tumors, migrate through the peritumoral stroma and reach the circulation. This is a highly dynamic process occurring in three dimensions that involves interactions between tumor, stromal cells, and the extracellular matrix. Here we describe the organotypic culture system and its utility to study breast cancer cell invasion induced by cancer-associated fibroblasts...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28632174/fluorescence-analysis-of-vitamin-d-receptor-status-of-circulating-tumor-cells-ctcs-in-breast-cancer-from-cell-models-to-metastatic-patients
#20
Xi Zhang, Simone Hofmann, Brigitte Rack, Nadia Harbeck, Udo Jeschke, Sophie Sixou
The Vitamin D receptor (VDR) expressed in normal breast tissue and breast tumors has been suggested as a new prognostic biomarker in breast cancer (BC). Besides, increasing evidence supports the view that the detection of circulating tumor cells (CTCs) predicts outcome in early and metastatic BC. Consequently, an evaluation of VDR expression in the CTCs of BC patients may allow optimization of their treatment. As an attempt to profile and subtype the CTCs of metastatic patients, we established an innovative fluorescence technique using nine BC cell lines to visualize, define, and compare their individual VDR status...
June 20, 2017: International Journal of Molecular Sciences
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