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https://www.readbyqxmd.com/read/28103562/a-decision-support-system-for-tele-monitoring-copd-related-worrisome-events
#1
Mario Merone, Claudio Pedone, Giuseppe Capasso, Raffaele Antonelli Incalzi, Paolo Soda
Chronic Obstructive Pulmonary Disease (COPD) is a preventable, treatable and slowly progressive disease, whose course is aggravated by a periodic worsening of symptoms and lung function lasting for several days. The development of home telemonitoring systems has made possible to collect symptoms and physiological data in electronic records, boosting the development of decision support systems (DSSs). Current DSSs work with physiological measurements collected by means of several measuring and communication devices as well as with symptoms gathered by questionnaires submitted to COPD subjects...
January 17, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28103448/bedside-contribution-of-electrical-impedance-tomography-to-set-positive-end-expiratory-pressure-for-ecmo-treated-severe-ards-patients
#2
Guillaume Franchineau, Nicolas Bréchot, Guillaume Lebreton, Guillaume Hekimian, Ania Nieszkowska, Jean-Louis Trouillet, Pascal Leprince, Jean Chastre, Charles-Edouard Luyt, Alain Combes, Matthieu Schmidt
RATIONALE: Optimal positive end-expiratory pressure (PEEP) is unknown in severe acute respiratory distress syndrome (ARDS) patients on extracorporeal membrane oxygenation (ECMO) receiving mechanical ventilation with very low tidal volume. OBJECTIVES: To evaluate electrical impedance tomography's (EIT) ability to monitor a PEEP trial and to derive from EIT the best compromise PEEP in this setting. METHODS: A decremental PEEP trial (20-0 cmH2O) in 5 cmH2O steps was monitored by EIT, with lung images divided into four ventral-to-dorsal horizontal regions of interest...
January 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28102830/can-exhaled-volatile-organic-compounds-predict-asthma-exacerbations-in-children
#3
Dillys van Vliet, Agnieszka Smolinska, Quirijn Jöbsis, Jean Muris, Philippe Rosias, Jan Dallinga, Edward Dompeling, Frederik van Schooten
Background Asthma control falls short of current goals of asthma management guidelines. Non-invasive monitoring of airway inflammation may help to improve the level of asthma control in children. Aim 1) To identify a set of exhaled volatile organic compounds (VOCs) that is most predictive for an asthma exacerbation in children. 2) To determine the chemical background of predictive VOCs. Methods In an one-year prospective observational study, 96 asthmatic children were studied . At clinical visits with an interval of 2 months, asthma control, fractional exhaled nitric oxide, lung function (FEV1, FEV1/VC) and VOCs in exhaled breath were determined by means of gas chromatography time-of-flight mass spectrometry...
January 19, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28101802/cold-pcr-technologies-in-the-area-of-personalized-medicine-methodology-and-applications
#4
REVIEW
Florence Mauger, Alexandre How-Kit, Jörg Tost
Somatic mutations bear great promise for use as biomarkers for personalized medicine, but are often present only in low abundance in biological material and are therefore difficult to detect. Many assays for mutation analysis in cancer-related genes (hotspots) have been developed to improve diagnosis, prognosis, prediction of drug resistance, and monitoring of the response to treatment. Two major approaches have been developed: mutation-specific amplification methods and methods that enrich and detect mutations without prior knowledge on the exact location and identity of the mutation...
January 18, 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/28101650/speech-disorders-in-parkinson-s-disease-early-diagnostics-and-effects-of-medication-and-brain-stimulation
#5
REVIEW
L Brabenec, J Mekyska, Z Galaz, Irena Rektorova
Hypokinetic dysarthria (HD) occurs in 90% of Parkinson's disease (PD) patients. It manifests specifically in the areas of articulation, phonation, prosody, speech fluency, and faciokinesis. We aimed to systematically review papers on HD in PD with a special focus on (1) early PD diagnosis and monitoring of the disease progression using acoustic voice and speech analysis, and (2) functional imaging studies exploring neural correlates of HD in PD, and (3) clinical studies using acoustic analysis to evaluate effects of dopaminergic medication and brain stimulation...
January 18, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28099884/characterization-of-human-and-staphylococcus-aureus-proteins-in-respiratory-mucosa-by-in-vivo-and-immunoproteomics
#6
Frank Schmidt, Tanja Meyer, Nandakumar Sundaramoorthy, Stephan Michalik, Kristin Surmann, Maren Depke, Vishnu Dhople, Manuela Gesell Salazar, Gabriele Holtappels, Nan Zhang, Barbara M Bröker, Claus Bachert, Uwe Völker
: Staphylococcus aureus is a Gram-positive opportunistic bacterium which can be found as a commensal in the nares of about 50% of the human population. Besides asymptomatic carriage, S. aureus has also been found to colonize nasal polyps, a subform of chronic rhinosinusitis, in 60 to 100% of cases, and even reside intracellularly in nasal polyp tissue. The aim of this study was to shed light on the behavior of S. aureus in the human airways by analyzing S. aureus-specific proteins in nasal polyp tissue from patients with chronic rhinosinusitis and to characterize the immunogenic potential of the identified (mainly secreted) proteins...
January 15, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28099598/dermatoscopy-guided-therapy-of-pigmented-basal-cell-carcinoma-with-imiquimod
#7
Husein Husein-ElAhmed, Maria Antonia Fernandez-Pugnaire
BACKGROUND: Dermatoscopy is a non-invasive diagnostic tool used to examine skin lesions with an optical magnification. It has been suggested as a useful tool for monitoring therapeutic response in lentigo maligna patients treated with imiquimod. OBJECTIVE: To examine the accuracy of dermatoscopy as a tool to monitor the therapeutic response of pigmented basal cell carcinoma treated with imiquimod. METHOD: The authors designed a prospective study...
November 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28099168/a-non-invasive-approach-to-investigation-of-ventricular-blood-pressure-using-cardiac-sound-features
#8
Hong Tang, Jinghui Zhang, Huaming Chen, Ashok Mondal, Yongwan Park
Heart sounds (HSs) are produced by the interaction of the heart valves, great vessels, and heart wall with blood flow. Previous researchers have demonstrated that blood pressure can be predicted by exploring the features of cardiac sounds. These features include the amplitude of the HSs, the ratio of the amplitude, the systolic time interval, and the spectrum of the HSs. A single feature or combinations of several features have been used for prediction of blood pressure with moderate accuracy. Experiments were conducted with three beagles under various levels of blood pressure induced by different doses of epinephrine...
January 18, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28098265/depth-selective-photothermal-ir-spectroscopy-of-skin-potential-application-for-non-invasive-glucose-measurement
#9
Otto Hertzberg, Alexander Bauer, Arne Küderle, Miguel A Pleitez, Werner Mäntele
An infrared spectroscopic technique is described that employs a mid-IR broadband (980-1245 cm(-1)) tunable quantum cascade laser (QCL) to produce a pump beam, and a detection method based on photothermal deflection, enhanced by total internal reflection. The IR spectra thus obtained are depth-dependent by modulating the pump beam with different frequencies between 10 Hz and 500 Hz. A model system consisting of glucose and a polymer film is used to demonstrate the depth selectivity of this technique. We also apply this photothermal depth profiling method to record in vivo IR spectra of the human epidermis at different depths...
January 18, 2017: Analyst
https://www.readbyqxmd.com/read/28097744/in-situ-electrical-monitoring-of-cancer-cells-invading-vascular-endothelial-cells-with-semiconductor-based-biosensor
#10
Toshiya Sakata, Yusuke Matsuse
Cellular dynamics is very closely related to ionic behaviors, most of which have been hardly monitored in real time, whereas semiconductor-based biosensors have the unique advantage of direct detection of ionic charges in a real-time and noninvasive manner. In this study, we monitored the invasion process of cancer cells into the vascular endothelial layer in real time by a label-free method using a field-effect transistor (FET) biosensor. Endothelial cells were cultured on the sensing surface of the FET gate, to form a basement membrane between the endothelial cells and the sensing surface...
January 18, 2017: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/28097660/in-brief-myeloid-derived-suppressor-cells-in-cancer
#11
S Solito, L Pinton, S Mandruzzato
The role of myeloid-derived suppressor cells (MDSCs) in cancer development has become clear over recent years and MDSC targeting is an emerging opportunity for enhancing the effectiveness of current anti-cancer therapies. Since MDSCs are not only able to limit anti-tumour T cell responses, but also promote tumour angiogenesis and invasion, their monitoring has prognostic and predictive value. Herein we review the key features of MDSCs in cancer promotion.
January 18, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28097330/electroencephalographic-periodic-discharges-and-frequency-dependent-brain-tissue-hypoxia-in-acute-brain-injury
#12
Jens Witsch, Hans-Peter Frey, J Michael Schmidt, Angela Velazquez, Cristina M Falo, Michael Reznik, David Roh, Sachin Agarwal, Soojin Park, E Sander Connolly, Jan Claassen
Importance: Periodic discharges (PDs) that do not meet seizure criteria, also termed the ictal interictal continuum, are pervasive on electroencephalographic (EEG) recordings after acute brain injury. However, their association with brain homeostasis and the need for clinical intervention remain unknown. Objective: To determine whether distinct PD patterns can be identified that, similar to electrographic seizures, cause brain tissue hypoxia, a measure of ongoing brain injury...
January 9, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28097210/preclinical-positron-emission-tomography-scanner-based-on-a-monolithic-annulus-of-scintillator-initial-design-study
#13
Alexander V Stolin, Peter F Martone, Gangadhar Jaliparthi, Raymond R Raylman
Positron emission tomography (PET) scanners designed for imaging of small animals have transformed translational research by reducing the necessity to invasively monitor physiology and disease progression. Virtually all of these scanners are based on the use of pixelated detector modules arranged in rings. This design, while generally successful, has some limitations. Specifically, use of discrete detector modules to construct PET scanners reduces detection sensitivity and can introduce artifacts in reconstructed images, requiring the use of correction methods...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28096576/role-of-edaravone-in-managemant-of-septic-peritonitis
#14
Ghada Fouad Elbaradey, Nagat Sayed Elshmaa, Hossam Hodeib
BACKGROUND AND AIMS: Sepsis is a complex rapidly progressive infectious disease that remain a major cause of morbidity and mortality in surgical patients and trauma victims. Edaravone a novel free radical scavenger was approved in 2001 in Japan for treatment of acute cerebral and myocardial infarction. Hence, in this work we attempt to evaluate its role in cases of septic peritonitis (SP). MATERIAL AND METHODS: This is a prospective randomized observer-blinded study carried out in surgical Intensive Care Unit (ICU) after approval by Hospital Ethical Committee...
October 2016: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/28096363/an-rna-based-signature-enables-high-specificity-detection-of-circulating-tumor-cells-in-hepatocellular-carcinoma
#15
Mark Kalinich, Irun Bhan, Tanya T Kwan, David T Miyamoto, Sarah Javaid, Joseph A LiCausi, John D Milner, Xin Hong, Lipika Goyal, Srinjoy Sil, Melissa Choz, Uyen Ho, Ravi Kapur, Alona Muzikansky, Huidan Zhang, David A Weitz, Lecia V Sequist, David P Ryan, Raymond T Chung, Andrew X Zhu, Kurt J Isselbacher, David T Ting, Mehmet Toner, Shyamala Maheswaran, Daniel A Haber
Circulating tumor cells (CTCs) are shed into the bloodstream by invasive cancers, but the difficulty inherent in identifying these rare cells by microscopy has precluded their routine use in monitoring or screening for cancer. We recently described a high-throughput microfluidic CTC-iChip, which efficiently depletes hematopoietic cells from blood specimens and enriches for CTCs with well-preserved RNA. Application of RNA-based digital PCR to detect CTC-derived signatures may thus enable highly accurate tissue lineage-based cancer detection in blood specimens...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28095555/megasessions-for-robotic-hair-restoration
#16
Joa O Carlos Pereira, Joa O Carlos Pereira Filho, Joa O Pedro Cabrera Pereira
A robotic system can select and remove individual hair follicles from the donor area with great precision and without fatigue. This report describes the use of the robotic system in a megasession for hair restoration. Patients were instructed to cut their hair to 1.0 to 1.2 mm before surgery. The robot selected and removed 600 to 800 grafts per hour so the follicular units (FU)s could be transplanted manually to recipient sites. The robot arm consists of a sharp inner punch and a blunt outer punch which together separate FUs from the sur- rounding tissue...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095550/the-diagnostic-role-of-optical-coherence-tomography-oct-in-measuring-the-depth-of-burn-and-traumatic-scars-for-more-accurate-laser-dosimetry-pilot-study
#17
Jill S Waibel, Ashley C Rudnick, Adam J Wulkan, Jon D Holmes
BACKGROUND: In recent decades, a number of optimal diagnostic technologies have emerged to assist in tissue visualization. Real-time monitoring of skin during laser therapies will help optimize laser parameters for more ef cient therapies. One of these technologies, optimal coherence tomography (OCT), may be used to help visualize burn and traumatic scars. When lasing severe scars, lasers have tunable pulse energies, which are made proportional to the scar thickness as estimated by palpation and the physician eye...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095547/prospective-internally-controlled-blind-reviewed-clinical-evaluation-of-cryolipolysis-combined-with-multipolar-radiofrequency-andvaripulsetechnology-for-enhanced-subject-results-in-circumferential-fat-reduction-and-skin-laxity-of-the-flanks
#18
Julius Few, Michael Gold, Neil Sadick
BACKGROUND: Increasing demand for non-invasive skin tightening and body contouring procedures has led to several technological in- novations in energy-based devices such as ultrasound, radiofrequency and cryolipolysis. An emerging trend in the eld is to evaluate whether combination therapies for skin laxity/body contouring using energy-based devices can deliver superior clinical results and patient satisfaction. As such, the objective of this prospective, internal-controlled, blind clinical study was to assess the safety and efficacy of cryolipolysis followed by multipolar radiofrequency with pulsed electromagnetic elds (PEMF) and adjustable pulsed suction for the treatment of skin laxity in the flanks...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095075/a-pilot-study-using-entropy-as-a-non-invasive-assessment-of-running
#19
Andrew M Murray, Joong Hyun Ryu, John Sproule, Anthony P Turner, Phil Graham-Smith, Marco Cardinale
PURPOSE: Running performance is influenced by the interaction of biomechanical and physiological factors. Miniaturised accelerometers worn by the athlete can be used to quantify mechanical aspects of running and be used as a non-invasive tool to assess training status and progression. The aim of this study was to define and validate a method to assess running regularity and allow the estimation of an individual's V̇O2 and/or blood lactate [La]b based on data collected with accelerometers and heart rate (HR)...
January 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28094329/fumarase-activity-an-in-vivo-and-in-vitro-biomarker-for-acute-kidney-injury
#20
Per Mose Nielsen, Abubakr Eldirdiri, Lotte Bonde Bertelsen, Hans Stødkilde Jørgensen, Jan Henrik Ardenkjaer-Larsen, Christoffer Laustsen
Renal ischemia/reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), and at present, there is a lack of reliable biomarkers that can diagnose AKI and measure early progression because the commonly used methods cannot evaluate single-kidney IRI. Hyperpolarized [1,4-(13)C2]fumarate conversion to [1,4-(13)C2]malate by fumarase has been proposed as a measure of necrosis in rat tumor models and in chemically induced AKI rats. Here we show that the degradation of cell membranes in connection with necrosis leads to elevated fumarase activity in plasma and urine and secondly that hyperpolarized [1,4-(13)C2]malate production 24 h after reperfusion correlates with renal necrosis in a 40-min unilateral ischemic rat model...
January 17, 2017: Scientific Reports
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