keyword
https://read.qxmd.com/read/38458594/tumor-associated-macrophages-drive-glycolysis-through-the-il-8-stat3-glut3-signaling-pathway-in-pancreatic-cancer-progression
#1
JOURNAL ARTICLE
Ziyi Zhong, Kege Yang, Yunlong Li, Shurui Zhou, Hanming Yao, Yue Zhao, Yuzhou Huang, Jinmao Zou, Yaqing Li, Jiajia Li, Guoda Lian, Kaihong Huang, Shaojie Chen
Glycolytic metabolism is a hallmark of pancreatic ductal adenocarcinoma (PDAC), and tumor-associated stromal cells play important roles in tumor metabolism. We previously reported that tumor-associated macrophages (TAMs) facilitate PDAC progression. However, little is known about whether TAMs are involved in regulating glycolysis in PDAC. Here, we found a positive correlation between CD68+ TAM infiltration and FDG maximal standardized uptake (FDG SUVmax) on PET-CT images of PDAC. We discovered that the glycolytic gene set was prominently enriched in the high TAM infiltration group through Gene Set Enrichment Analysis using The Cancer Genome Atlas database...
March 6, 2024: Cancer Letters
https://read.qxmd.com/read/38393465/the-role-of-cxcl1-in-crosstalk-between-endocrine-resistant-breast-cancer-and-fibroblast
#2
JOURNAL ARTICLE
Sneha Pandithar, Daniel Galke, Ahone Akume, Artem Belyakov, Dominick Lomonaco, Amirah A Guerra, Jay Park, Olivia Reff, Kideok Jin
BACKGROUND: ER positive breast cancer is currently targeted using various endocrine therapies. Despite the proven therapeutic efficacy, resistance to the drug and reoccurrence of tumor appears to be a complication that many patients deal with. Molecular pathways underlying the development of resistance are being widely studied. METHODS AND RESULTS: In this study, using four established endocrine resistant breast cancer (ERBC) cell lines, we characterized CXCL1 as a secreted factor in crosstalk between ERBC cells and fibroblasts...
February 23, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38387232/interferon-%C3%AE-induces-differentiation-of-cancer-stem-cells-and-immunosuppression-in-hepatocellular-carcinoma-by-upregulating-cxcl8-secretion
#3
JOURNAL ARTICLE
Yu-Ting Ma, Lu Zheng, Cheng-Wen Zhao, Yue Zhang, Xin-Wei Xu, Xin-Yu Wang, Guo-Ping Niu, Zhong-Song Man, Feng Gu, Yong-Qiang Chen
Interferon-alpha (IFN-α) is widely used in the clinical treatment of patients with chronic hepatitis B and hepatocellular carcinoma (HCC). However, high levels of CXCL8 are associated with resistance to IFN-α therapy and poorer prognosis in advanced cancers. In this study, we investigated whether IFN-α could directly induce the production of CXCL8 in HCC cells and whether CXCL8 could antagonize the antitumor activity of IFN-α. We found that IFN-α not only upregulated the expression of the inducible genes CXCL9, CXCL10, CXCL11 and PD-L1, but also significantly stimulated CXCL8 secretion in HCC cells...
February 21, 2024: Cytokine
https://read.qxmd.com/read/38181674/blocking-cxcr1-2-attenuates-experimental-periodontitis-by-suppressing-neutrophils-recruitment
#4
JOURNAL ARTICLE
Yunjia Huang, Jichen Yang, Yong Zhang, Shuhong Kuang, Zongshan Shen, Wei Qin
Periodontitis (PD) is a common chronic oral inflammatory disease that cause alveolar bone loss. Current strategies for bone regeneration achieve limited results in PD. The aberrant host osteoimmunity to pathogenic bacteria is responsible for the destruction of alveolar bone in PD. We aimed to investigate the distinctive activity of immune cells in PD to create more effective and precise therapeutic approaches for treating PD. In this study, we revealed that neutrophils in the inflamed alveolar bone of PD patients expressed higher levels of CXCR1/2 and had a stronger pro-inflammatory capacity and chemotactic ability than that in healthy individuals...
January 4, 2024: International Immunopharmacology
https://read.qxmd.com/read/37972723/neutrophils-as-potential-therapeutic-targets-for-breast-cancer
#5
REVIEW
Yi-Ting Gong, Li-Jun Zhang, Yi-Chen Liu, Min Tang, Jia-Yi Lin, Xin-Yi Chen, Yi-Xu Chen, Yue Yan, Wei-Dong Zhang, Jin-Mei Jin, Xin Luan
Breast cancer (BC) remains the foremost cause of cancer mortality globally, with neutrophils playing a critical role in its pathogenesis. As an essential tumor microenvironment (TME) component, neutrophils are emerging as pivotal factors in BC progression. Growing evidence has proved that neutrophils play a Janus- role in BC by polarizing into the anti-tumor (N1) or pro-tumor (N2) phenotype. Clinical trials are evaluating neutrophil-targeted therapies, including Reparixin (NCT02370238) and Tigatuzumab (NCT01307891); however, their clinical efficacy remains suboptimal...
November 14, 2023: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/37846957/plasmon-enhanced-circular-dichroism-spectroscopy-of-chiral-drug-solutions
#6
JOURNAL ARTICLE
Matteo Venturi, Raju Adhikary, Ambaresh Sahoo, Carino Ferrante, Isabella Daidone, Francesco Di Stasio, Andrea Toma, Francesco Tani, Hatice Altug, Antonio Mecozzi, Massimiliano Aschi, Andrea Marini
We investigate the potential of surface plasmon polaritons at noble metal interfaces for surface-enhanced chiroptical sensing of dilute chiral drug solutions with nl volume. The high quality factor of surface plasmon resonances in both Otto and Kretschmann configurations enables the enhancement of circular dichroism differenatial absorption thanks to the large near-field intensity of such plasmonic excitations. Furthermore, the subwavelength confinement of surface plasmon polaritons is key to attain chiroptical sensitivity to small amounts of drug volumes placed around ≃100 nm by the metal surface...
October 21, 2023: Journal of Chemical Physics
https://read.qxmd.com/read/37798468/efficacy-and-safety-of-reparixin-in-patients-with-severe-covid-19-pneumonia-a-phase-3-randomized-double-blind-placebo-controlled-study
#7
JOURNAL ARTICLE
Lorenzo Piemonti, Giovanni Landoni, Antonio Voza, Massimo Puoti, Ivan Gentile, Nicola Coppola, Stefano Nava, Alessia Mattei, Franco Marinangeli, Giulia Marchetti, Paolo Bonfanti, Claudio Maria Mastroianni, Matteo Bassetti, Ernesto Crisafulli, Paolo Antonio Grossi, Alberto Zangrillo, Antonio Desai, Marco Merli, Maria Foggia, Marco Carpano, Lorenzo Schiavoni, Antonella D'Arminio Monforte, Luca Bisi, Gianluca Russo, Fabiana Busti, Cristina Rovelli, Elisabetta Perrotta, Giovanni Goisis, Elizabeth M Gavioli, Sophie Toya, Maria De Pizzol, Flavio Mantelli, Marcello Allegretti, Enrico Maria Minnella
INTRODUCTION: Polymorphonuclear cell influx into the interstitial and bronchoalveolar spaces is a cardinal feature of severe coronavirus disease 2019 (COVID-19), principally mediated by interleukin-8 (IL-8). We sought to determine whether reparixin, a novel IL-8 pathway inhibitor, could reduce disease progression in patients hospitalized with severe COVID-19 pneumonia. METHODS: In this Phase 3, randomized, double-blind, placebo-controlled, multicenter study, hospitalized adult patients with severe COVID-19 pneumonia were randomized 2:1 to receive oral reparixin 1200 mg three times daily or placebo for up to 21 days or until hospital discharge...
October 5, 2023: Infectious Diseases and Therapy
https://read.qxmd.com/read/37570736/targeting-members-of-the-chemokine-family-as-a-novel-approach-to-treating-neuropathic-pain
#8
REVIEW
Katarzyna Pawlik, Joanna Mika
Neuropathic pain is a debilitating condition that affects millions of people worldwide. Numerous studies indicate that this type of pain is a chronic condition with a complex mechanism that tends to worsen over time, leading to a significant deterioration in patients' quality of life and issues like depression, disability, and disturbed sleep. Presently used analgesics are not effective enough in neuropathy treatment and may cause many side effects due to the high doses needed. In recent years, many researchers have pointed to the important role of chemokines not only in the development and maintenance of neuropathy but also in the effectiveness of analgesic drugs...
July 30, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/37508478/cxcr2-is-deregulated-in-als-spinal-cord-and-its-activation-triggers-apoptosis-in-motor-neuron-like-cells-overexpressing-hsod1-g93a
#9
JOURNAL ARTICLE
Valentina La Cognata, Agata Grazia D'Amico, Grazia Maugeri, Giovanna Morello, Maria Guarnaccia, Benedetta Magrì, Eleonora Aronica, Velia D'Agata, Sebastiano Cavallaro
Amyotrophic lateral sclerosis (ALS) is a multifactorial neurodegenerative disease characterized by progressive depletion of motor neurons (MNs). Recent evidence suggests a role in ALS pathology for the C-X-C motif chemokine receptor 2 (CXCR2), whose expression was found increased at both mRNA and protein level in cortical neurons of sporadic ALS patients. Previous findings also showed that the receptor inhibition is able to prevent iPSC-derived MNs degeneration in vitro and improve neuromuscular function in SOD1-G93A mice...
July 9, 2023: Cells
https://read.qxmd.com/read/37333089/monocyte-adhesion-and-transmigration-through-endothelium-following-cardiopulmonary-bypass-shearing-is-mediated-by-il-8-signaling
#10
Hao Zhou, Lan N Tu, Cecilia Giachelli, Vishal Nigam, Marta Scatena
BACKGROUND: The use of cardiopulmonary bypass (CPB) can induce sterile systemic inflammation that contributes to morbidity and mortality, especially in children. Patients have been found to have increased expression of cytokines and transmigration of leukocytes during and after CPB. Previous work has demonstrated that the supraphysiologic shear stresses present during CPB are sufficient to induce proinflammatory behavior in non-adherent monocytes. The interactions between shear stimulated monocytes and vascular endothelial cells have not been well studied and have important translational implications...
June 6, 2023: bioRxiv
https://read.qxmd.com/read/37161521/reparixin-improves-survival-in-critically-ill-and-transplant-patients-a-meta-analysis
#11
REVIEW
Gioia Piersanti, Giovanni Landoni, Tommaso Scquizzato, Alberto Zangrillo, Lorenzo Piemonti
BACKGROUND: Reparixin, an anti-inflammatory drug that inhibits interleukin 8 (IL-8) activity, might be life-saving for high-risk in-hospital patients without increasing the risk of infection according to a previous meta-analysis. With the increasing availability of randomised data the aim of the current study is to update previous findings by including any randomised control trials (RCTs) investigating the impact of reparixin on survival of critically ill or transplant patients. METHODS: A search strategy was developed to identify all RCTs involving reparixin in critically ill or transplant patients, with the exclusion of oncological patients...
May 9, 2023: European Journal of Clinical Investigation
https://read.qxmd.com/read/37137833/-roles-of-the-cxcr1-cxcl8-axis-in-abnormal-proliferation-of-bile-duct-epithelial-cells-in-primary-biliary-cholangitis
#12
JOURNAL ARTICLE
X Ai, H Y Fu, J M Xu, W X Yang, Y M Tang
Objective: To investigate the role of the CXC chemokine receptor 1 (CXCR1)/CXC chemokine ligand 8 (CXCL8) axis in the abnormal proliferation of bile duct epithelial cells in primary biliary cholangitis (PBC). Methods: 30 female C57BL/6 mice were randomly divided into the PBC model group (PBC group), reparixin intervention group (Rep group), and blank control group (Con group) in an in vivo experiment. PBC animal models were established after 12 weeks of intraperitoneal injection of 2-octanoic acid coupled to bovine serum albumin (2OA-BSA) combined with polyinosinic acid polycytidylic acid (polyI:C)...
February 20, 2023: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://read.qxmd.com/read/37096507/-the-effects-and-regulatory-mechanism-of-targeting-cxc-chemokine-receptor-1-2-combined-with-ara-c-on-the-malignant-biological-behaviors-of-u937-cells-of-acute-myeloid-leukemia
#13
JOURNAL ARTICLE
Yan-Quan Liu, Jian-Zhen Shen, Yue Yin, Yu-Ting Chen, Hui Yang, Huan-Wen Tang
OBJECTIVE: To investigate and analyze the effect of CXC chemokine receptor 1/2 (CXCR1/2) targeting inhibitor Reparixin combined with cytarabine (Ara-C) on the malignant biological behaviors of acute myeloid leukemia cells and its effect on the expression of the CXCR family, while exploring the accompanying molecular mechanism, providing scientific basis and reference for new molecular markers and targeted therapy for AML. METHODS: Acute myeloid leukemia U937 cells were treated with different concentrations of Reparixin, Ara-C alone or in combination, and the cell morphology was observed under an inverted microscope; Wright-Giemsa staining was used to detect cell morphological changes; CCK-8 method was used to detect cell proliferation; the ability of cell invasion was detected by Transwell chamber method; the ability of colony formation was detected by colony formation assay; cell apoptosis was detected by Hoechst 33258 fluorescent staining and Annexin V/PI double-staining flow cytometry; monodansylcadaverine(MDC) staining was used to detect cell autophagy; the expression of apoptosis, autophagy and related signaling pathway proteins was detected by Western blot and the expression changes of CXCR family were detected by real-time quantitative polymerase chain reaction (qRT-PCR)...
April 2023: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/37056297/dicer-suppresses-hepatocellular-carcinoma-via-interleukin-8-pathway
#14
JOURNAL ARTICLE
Xin Han, Jianhua Wu, Ziyue Sha, Ruixue Lai, Jianfei Shi, Lili Mi, Fei Yin, Zhanjun Guo
BACKGROUND: Elevated level of interleukin-8 (IL-8) promotes hepatocellular carcinoma (HCC) development and contributes to poor prognosis. Previously, we have proved that Dicer inhibits HCC progression. In this study, we evaluated the potential interaction between IL-8 and Dicer as well as their influence on HCC. METHODS: Hepatocellular carcinoma cells of SMMC-7721 were divided into 2 groups for subsequent analysis: pCMV-Dicer group for Dicer-overexpressing lentivirus transfected cells (pCMV-Dicer cells) and pCMV-NC group for empty lentivirus transfected cells (pCMV-NC cells)...
2023: Clinical Medicine Insights. Oncology
https://read.qxmd.com/read/36863479/inhibition-of-cxcr1-2-reduces-the-emperipolesis-between-neutrophils-and-megakaryocytes-in-the-gata1-low-model-of-myelofibrosis
#15
JOURNAL ARTICLE
Francesca Arciprete, Paola Verachi, Fabrizio Martelli, Mauro Valeri, Manjola Balliu, Paola Guglielmelli, Alessandro Maria Vannucchi, Anna Rita Migliaccio, Maria Zingariello
Emperipolesis between neutrophils and megakaryocytes was first identified by transmission electron microscopy. Although rare under steady state conditions, its frequency greatly increases in myelofibrosis, the most severe of the Myeloproliferative Neoplasms where it is believed to contribute to increasing the TGF-β microenvironmental bioavailability responsible for fibrosis. The challenge of performing studies by transmission electron microscopy has hampered up to now the study of factors which drive the pathological emperipolesis observed in myelofibrosis...
February 28, 2023: Experimental Hematology
https://read.qxmd.com/read/36768178/prevention-of-chemotherapy-induced-peripheral-neuropathy-by-inhibiting-c-x-c-motif-chemokine-receptor-2
#16
JOURNAL ARTICLE
Hee Seong Cho, Young In Choi, Seon Uk Park, Yi Seul Han, Jean Kwon, Sung Jun Jung
Chemotherapy-induced peripheral neuropathy (CIPN) is a major drawback in the use of chemotherapeutic agents for patients with cancer. Although studies have investigated a broad number of molecules that might be related to CIPN, the differences in the chemokine pathways between various chemotherapeutic agents, such as vincristine and oxaliplatin, which are some of the most widely used treatments, have not been fully elucidated. We confirmed that the administration (intraperitoneal injections for seven days) of vincristine (0...
January 17, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/35958623/the-effect-of-reparixin-on-survival-in-patients-at-high-risk-for-in-hospital-mortality-a-meta-analysis-of-randomized-trials
#17
JOURNAL ARTICLE
Giovanni Landoni, Alberto Zangrillo, Gioia Piersanti, Tommaso Scquizzato, Lorenzo Piemonti
Introduction: A great number of anti-inflammatory drugs have been suggested in the treatment of SARS-CoV-2 infection. Reparixin, a non-competitive allosteric inhibitor of the CXCL8 (IL-8) receptors C-X-C chemokine receptor type 1 (CXCR1) and C-X-C chemokine receptor type 2 (CXCR2), has already been tried out as a treatment in different critical settings. Due to the contrasting existing literature, we decided to perform the present meta-analysis of randomized controlled trials (RCTs) to investigate the effect of the use of reparixin on survival in patients at high risk for in-hospital mortality...
2022: Frontiers in Immunology
https://read.qxmd.com/read/35805071/a-therapeutic-whole-tumor-cell-vaccine-covalently-conjugated-with-a-tlr7-agonist
#18
JOURNAL ARTICLE
Huju Chi, Yue Hao, Xia Wang, Li Tang, Yongqiang Deng, Xianxiong Chen, Feng Gao, Ou Sha, Guangyi Jin
A single-protein or -peptide vaccine is not sufficient to arouse immune responses in cancer therapy. A whole-tumor-cell vaccine with complete cancer cell antigens and all conformations elicits robust immune responses and is a promising method for the treatment of advanced malignant tumors. In this study, we used 5-azacitidine to stimulate B16-F10 melanoma cells to express toll-like receptor (TLR) 3 on the cell surface and then chemically linked SZU-106, a small-molecule TLR7 agonist, to the cell surface with a pegylated linker to produce a novel whole-tumor-cell vaccine, abbreviated as Aza-BFcell-106...
June 21, 2022: Cells
https://read.qxmd.com/read/35618953/a-multicenter-phase-2-randomized-controlled-study-on-the-efficacy-and-safety-of-reparixin-in-the-treatment-of-hospitalized-patients-with-covid-19-pneumonia
#19
JOURNAL ARTICLE
Giovanni Landoni, Lorenzo Piemonti, Antonella d'Arminio Monforte, Paolo Grossi, Alberto Zangrillo, Enrico Bucci, Marcello Allegretti, Giovanni Goisis, Elizabeth M Gavioli, Neal Patel, Maria De Pizzol, Georgea Pasedis, Flavio Mantelli
INTRODUCTION: Acute lung injury and acute respiratory distress syndrome are common complications in patients with coronavirus disease 2019 (COVID-19). Poor outcomes in patients with COVID-19 are associated with cytokine release syndrome. Binding of interleukin-8 (CXCL8/IL-8) to its chemokine receptors, CXCR1/2, may mediate this inflammatory process. The aim of this clinical trial was to determine if CXCR1/2 blockade with reparixin can improve clinical outcomes in hospitalized patients with severe COVID-19 pneumonia...
May 26, 2022: Infectious Diseases and Therapy
https://read.qxmd.com/read/35599941/the-protective-effects-of-reparixin-against-endothelial-ischemia-reperfusion-injury
#20
JOURNAL ARTICLE
Piyanuch Thitiwuthikiat, Tamonlak Ta-Uea, Theeraya Ponghan, Saranya Meebua, Duangduan Siriwittayawan, Teonchit Nuamchit
Objectives: Myocardial ischemia is a lack of blood supply to myocardial tissue. Rapid reperfusion therapy is required to prevent myocardial infarction. However, ischemia and reperfusion contribute to myocardial and endothelial injury or ischemia-reperfusion injury (IRI). A pro-inflammatory cytokine interleukin-8 (IL-8/CXCL8) plays an important role in the activation of neutrophil accumulation and promotes endothelial dysfunction. Therefore, inhibition of IRI through the regulation of inflammation using a CXCL8 receptor inhibitor reparixin is an attractive target...
May 2022: International Journal of Health Sciences
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