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https://www.readbyqxmd.com/read/28733615/impact-of-natural-blind-spot-location-on-perimetry
#1
Mengyu Wang, Lucy Q Shen, Michael V Boland, Sarah R Wellik, Carlos Gustavo De Moraes, Jonathan S Myers, Peter J Bex, Tobias Elze
We study the spatial distribution of natural blind spot location (NBSL) and its impact on perimetry. Pattern deviation (PD) values of 11,449 reliable visual fields (VFs) that are defined as clinically unaffected based on summary indices were extracted from 11,449 glaucoma patients. We modeled NBSL distribution using a two-dimensional non-linear regression approach and correlated NBSL with spherical equivalent (SE). Additionally, we compared PD values of groups with longer and shorter distances than median, and larger and smaller angles than median between NBSL and fixation...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28732043/investigation-of-horizontal-gene-transfer-of-pathogenicity-islands-in-escherichia-coli-using-next-generation-sequencing
#2
Maxim Messerer, Wolfgang Fischer, Sören Schubert
Horizontal gene transfer (HGT) contributes to the evolution of bacteria. All extraintestinal pathogenic Escherichia coli (ExPEC) harbour pathogenicity islands (PAIs), however relatively little is known about the acquisition of these PAIs. Due to these islands, ExPEC have properties to colonize and invade its hosts efficiently. Even though these PAIs are known to be acquired by HGT, only very few PAIs do carry mobilization and transfer genes required for the transmission by HGT. In this study, we apply for the first time next-generation sequencing (NGS) and in silico analyses in combination with in vitro experiments to decipher the mechanisms of PAI acquisition in ExPEC...
2017: PloS One
https://www.readbyqxmd.com/read/28731396/contralateral-posterior-interhemispheric-approach-to-deep-medial-parietooccipital-vascular-malformations-surgical-technique-and-results
#3
Jan-Karl Burkhardt, Ethan A Winkler, Michael T Lawton
OBJECTIVE Deep medial parietooccipital arteriovenous malformations (AVMs) and cerebral cavernous malformations (CCMs) are traditionally resected through an ipsilateral posterior interhemispheric approach (IPIA), which creates a deep, perpendicular perspective with limited access to the lateral margins of the lesion. The contralateral posterior interhemispheric approach (CPIA) flips the positioning, with the midline positioned horizontally for retraction due to gravity, but with the AVM on the upper side and the approach from the contralateral, lower side...
July 21, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28728906/surgical-management-of-strabismus-following-choroidal-melanoma-plaque-brachytherapy
#4
Shatha H Alfreihi, Stacy L Pineles, Tara A McCannel, Angelica M Prada, Federico G Velez
PURPOSE: To characterize intraoperative findings, surgical approach, and postoperative outcomes in patients undergoing strabismus surgery following plaque brachytherapy for ocular melanoma. METHODS: The records of all patients who underwent plaque brachytherapy for choroidal melanoma between May 2007 and June 2016 were reviewed retrospectively to identify those who subsequently required strabismus surgery. RESULTS: Of the 461 patients who underwent plaque brachytherapy during the study period, 13 (2...
July 17, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28727462/tridimensional-reconstruction-of-a-complex-iatrogenic-defect-using-orthodontic-forced-eruption-and-minimally-invasive-bone-grafting
#5
Ernesto A Lee
As the use of dental implants has become more common, so has the frequency of complications and unforeseen outcomes. This article describes the treatment of a complex iatrogenic defect secondary to a failed implant (No. 7) and multiple bone-grafting attempts in the maxillary anterior region. The patient's revealing smile line and high-risk circumstances demanded the use of an interdisciplinary treatment approach with high potential for predictable esthetic results. Forced eruption was performed to restore the alveolar height deficit and develop the compromised hard and soft tissues around teeth Nos...
July 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28717219/versatile-functional-roles-of-horizontal-cells-in-the-retinal-circuit
#6
Taro Chaya, Akihiro Matsumoto, Yuko Sugita, Satoshi Watanabe, Ryusuke Kuwahara, Masao Tachibana, Takahisa Furukawa
In the retinal circuit, environmental light signals are converted into electrical signals that can be decoded properly by the brain. At the first synapse of the visual system, information flow from photoreceptors to bipolar cells is modulated by horizontal cells (HCs), however, their functional contribution to retinal output and individual visual function is not fully understood. In the current study, we investigated functional roles for HCs in retinal ganglion cell (RGC) response properties and optokinetic responses by establishing a HC-depleted mouse line...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716960/bacterial-tubulin-a-b-exhibit-polarized-growth-mixed-polarity-bundling-and-destabilization-by-gtp-hydrolysis
#7
César Díaz-Celis, Viviana I Risca, Felipe Hurtado, Jessica K Polka, Scott D Hansen, Daniel Maturana, Rosalba Lagos, R Dyche Mullins, Octavio Monasterio
Bacteria of the genus Prosthecobacter express homologs of eukaryotic α- and β-tubulin, called BtubA and BtubB, that have been observed to assemble into filaments in presence of GTP. BtubA/B polymers are proposed to be composed in vitro by two to six protofilaments, in contrast to in vivo where they have been reported to form 5-protofilaments tubes named bacterial microtubules (bMTs). The btubAB genes likely entered the Prosthecobacter lineage via horizontal gene transfer and may derive from an early ancestor of the modern eukaryotic microtubule (MT)...
July 17, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28714096/enactors-of-horizontal-violence-the-pathological-bully-the-self-justified-bully-and-the-unprofessional-co-worker
#8
Rosemary A Taylor, Steven S Taylor
AIM: To suggest an alternative approach to improving recognition of horizontal violence using enactor types identified in a study exploring nurses' perceptions of horizontal violence. BACKGROUND: Horizontal violence is an umbrella term used to describe a range of aggressive behaviors between nurse colleagues. It is suggested that nurses do not recognize the phenomenon when they witness or experience it, contributing to its perpetuation. DESIGN: This was a qualitative, descriptive study undertaken to inform theory development and the design of future interventions to address horizontal violence...
July 16, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28710370/triazophos-tap-removal-in-horizontal-subsurface-flow-constructed-wetlands-hscws-and-its-accumulation-in-plants-and-substrates
#9
Juan Wu, Zhu Li, Liang Wu, Fei Zhong, Naxin Cui, Yanran Dai, Shuiping Cheng
Triazophos (TAP) is a widely used phosphorus pesticide in China that possesses a potential risk for water pollution. We have studied the removal efficiency of TAP using pilot-scale horizontal subsurface flow constructed wetlands (HSCWs) as well as the contribution of plants, substrates and other pathways to its removal. For TAP concentrations of 0.12 ± 0.04 mg L(-1), 0.79 ± 0.29 mg L(-1) and 3.96 ± 1.17 mg L(-1), the removal efficiencies were 94.2 ± 3.7%, 97.8 ± 2.9% and 84...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28709260/pneumatic-fractures-in-confined-granular-media
#10
Fredrik K Eriksen, Renaud Toussaint, Antoine L Turquet, Knut J Måløy, Eirik G Flekkøy
We perform experiments where air is injected at a constant overpressure P_{in}, ranging from 5 to 250 kPa, into a dry granular medium confined within a horizontal linear Hele-Shaw cell. The setup allows us to explore compacted configurations by preventing decompaction at the outer boundary, i.e., the cell outlet has a semipermeable filter such that beads are stopped while air can pass. We study the emerging patterns and dynamic growth of channels in the granular media due to fluid flow, by analyzing images captured with a high speed camera (1000 images/s)...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28708641/secondary-palatal-elongation-improvement-in-speech-quality
#11
Muzaffer Çelik
Cleft palate is one of the challenging problems in the field of craniofacial surgery. In particular, the conventional methods of bilateral and severe cleft palate repairs have failed to achieve normal speech. In most instances, secondary procedures such as pharyngoplasty and pharyngeal flap surgery are performed to improve speech.This study introduces secondary palatal elongation (SPE) as a new approach to cleft palate repair. The patients included usually had a short palate and unrepaired palatal muscles. The authors' procedure involved dissecting the previously repaired palatal mucosa and pushing back and cutting the nasal mucosa of the palate horizontally and further pushing it back...
July 13, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28706811/surgical-technique-for-arthroscopy-assisted-anatomical-reconstruction-of-acromioclavicular-and-coracoclavicular-ligaments-using-autologous-hamstring-graft-in-chronic-acromioclavicular-joint-dislocations
#12
Bancha Chernchujit, Prashant Parate
Injuries to the acromioclavicular (AC) joint are becoming common with contact sports and bike accidents. It is well known that in AC dislocations, the first structure to fail is the AC capsule followed by the trapezoid and conoid ligaments. The function of these ligaments must be restored to restore the anatomy and physiology of the AC joint to get the best results. Until now, no technique has emerged as the gold standard for restoration of the AC joint anatomy and function. In our technique, the stress is on recreating the anatomy to make it more individualized based on individual variations...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28698934/combination-of-w%C3%A3-ringer-s-horizontal-septum-and-inferior-pedicle-techniques-to-increase-nipple-areolar-complex-viability-during-breast-reduction-surgery
#13
Osman Kelahmetoglu, Remzi Firinciogullari, Caglayan Yagmur, Kemalettin Yildiz, Ethem Guneren
BACKGROUND: Breast reduction techniques depend on the vascularity of the pedicle. Preserving vascularity of the nipple-areolar complex (NAC) is mandatory for reduction mammoplasties, as the NAC is the most important aesthetic and functional unit of the breast. The inferior pedicle technique is the most common method for breast reduction; however, pedicle length may increase after using this technique and cause problems related to NAC viability in gigantomastic and hypertrophic breasts...
July 11, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28697729/the-relevance-of-different-trust-models-for-representation-in-patient-organizations-conceptual-considerations
#14
Helene Gerhards, Karin Jongsma, Silke Schicktanz
BACKGROUND: Trust within organizations is important for ensuring members' acceptance of the organization's activities and to expand their scope of action. Remarkably, Patient Organizations (POs) that often both function as a forum for self-help and represent patients on the health-political level, have been understudied in this respect. This paper analyzes the relation between trust and representation in POs. We distinguish between two models of representation originating from political theory: the trustee and delegate model and between two types of trust: horizontal and vertical trust...
July 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28693960/the-lateral-backdoor-approach-to-open-thyroid-surgery-a-comparative-study
#15
R M Singaporewalla, B C Tan, A D Rao
INTRODUCTION: The traditionally taught technique for conventional open thyroidectomy is via a midline splitting of the strap muscles following a skin crease neck incision - midline approach (MA). The lateral "backdoor" approach (LA) uses the same central neck incision but approaches the thyroid gland between the anterior border of sternocleidomastoid (SCM) and strap muscles. This technique is usually reserved for re-do thyroid surgery. We compared the results of the two approaches in patients undergoing conventional thyroidectomy for the first time...
July 8, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28690609/diversity-prevalence-and-longitudinal-occurrence-of-type-ii-toxin-antitoxin-systems-of-pseudomonas-aeruginosa-infecting-cystic-fibrosis-lungs
#16
Sandra B Andersen, Melanie Ghoul, Ashleigh S Griffin, Bent Petersen, Helle K Johansen, Søren Molin
Type II toxin-antitoxin (TA) systems are most commonly composed of two genes encoding a stable toxin, which harms the cell, and an unstable antitoxin that can inactivate it. TA systems were initially characterized as selfish elements, but have recently gained attention for regulating general stress responses responsible for pathogen virulence, formation of drug-tolerant persister cells and biofilms-all implicated in causing recalcitrant chronic infections. We use a bioinformatics approach to explore the distribution and evolution of type II TA loci of the opportunistic pathogen, Pseudomonas aeruginosa, across longitudinally sampled isolates from cystic fibrosis lungs...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28685906/a-morphology-independent-approach-for-identifying-dividing-adult-neural-stem-cells-in-the-mouse-hippocampus
#17
Lachlan Harris, Oressia Zalucki, Sabrina Oishi, Thomas H Burne, Dhanisha J Jhaveri, Michael Piper
Background Type 1 adult hippocampal neural stem cells (AH-NSCs) continue to generate neurons throughout life, albeit at a very low rate. The relative quiescence of this population of cells has led to many studies investigating factors that may increase their division. Current methods of identifying dividing AH-NSCs in vivo require the identification and tracing of radial processes back to nuclei within the subgranular zone. However, caveats to this approach include the time-intensive nature of identifying AH-NSCs with such a process, as well as the fact that this approach ignores the relatively more active population of horizontally oriented AH-NSCs that also reside in the subgranular zone...
July 7, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28684263/development-of-maltodextrin-based-immediate-release-tablets-using-an-integrated-twin-screw-hot-melt-extrusion-and-injection-molding-continuous-manufacturing-process
#18
Vibha Puri, Dave Brancazio, Parind M Desai, Keith D Jensen, Jung-Hoon Chun, Allan S Myerson, Bernhardt L Trout
The combination of hot melt extrusion and injection molding (HME-IM) is a promising process technology for continuous manufacturing of tablets. However, there has been limited research on its application to formulate crystalline drug containing immediate release tablets. Further, studies that have applied the HME-IM process to molded tablets have used a non-continuous two-step approach. The current study develops maltodextrin (MDX) based extrusion molded immediate release tablets for a crystalline drug (griseofulvin, GRIS) using an integrated twin-screw HME-IM continuous process...
July 3, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28684255/prescription-extraction-using-crfs-and-word-embeddings
#19
Carson Tao, Michele Filannino, Özlem Uzuner
In medical practices, doctors detail patients' care plan via discharge summaries written in the form of unstructured free texts, which among the others contain medication names and prescription information. Extracting prescriptions from discharge summaries is challenging due to the way these documents are written. Handwritten rules and medical gazetteers have proven to be useful for this purpose but come with limitations on performance, scalability, and generalizability. We instead present a machine learning approach to extract and organize medication names and prescription information into individual entries...
July 3, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28682021/causes-and-surgical-outcomes-of-lower-eyelid-retraction
#20
Kun Hae Kim, Ji Sun Baek, Saem Lee, Jung Hye Lee, Hye Sun Choi, Sung Joo Kim, Jae Woo Jang
PURPOSE: To investigate the causes of lower eyelid retraction and evaluate the outcomes of various surgical procedures. METHODS: We conducted a retrospective medical record review of patients who underwent lower eyelid retraction surgery performed by a single surgeon at Kim's Eye Hospital between 2006 and 2013. We investigated the causes of lower eyelid retraction, clinical history, characteristics, treatment, and surgical outcomes. Preoperative and postoperative margin reflex distance 2 and inferior scleral show were measured for each eyelid...
July 4, 2017: Korean Journal of Ophthalmology: KJO
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