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https://www.readbyqxmd.com/read/28514687/particulate-array-of-well-ordered-hiv-clade-c-env-trimers-elicits-neutralizing-antibodies-that-display-a-unique-v2-cap-approach
#1
Paola Martinez-Murillo, Karen Tran, Javier Guenaga, Gustaf Lindgren, Monika Àdori, Yu Feng, Ganesh E Phad, Néstor Vázquez Bernat, Shridhar Bale, Jidnyasa Ingale, Viktoriya Dubrovskaya, Sijy O'Dell, Lotta Pramanik, Mats Spångberg, Martin Corcoran, Karin Loré, John R Mascola, Richard T Wyatt, Gunilla B Karlsson Hedestam
The development of soluble envelope glycoprotein (Env) mimetics displaying ordered trimeric symmetry has ushered in a new era in HIV-1 vaccination. The recently reported native, flexibly linked (NFL) design allows the generation of native-like trimers from clinical isolates at high yields and homogeneity. As the majority of infections world-wide are of the clade C subtype, we examined responses in non-human primates to well-ordered subtype C 16055 trimers administered in soluble or high-density liposomal formats...
May 16, 2017: Immunity
https://www.readbyqxmd.com/read/28513802/prevalence-and-factors-associated-with-self-reported-disability-a-comparison-between-genders
#2
Mônica Faria Felicíssimo, Amélia Augusta de Lima Friche, Amanda Cristina de Souza Andrade, Roseli Gomes de Andrade, Dário Alves da Silva Costa, César Coelho Xavier, Fernando Augusto Proietti, Waleska Teixeira Caiaffa
Objective: To estimate the prevalence of disability and its association with sociodemographic and health characteristics stratified by sex. Methods: This is a cross-sectional study with a probabilistic sample including 4,048 residents aged ≥ 18 years in two health districts of Belo Horizonte (MG), Brazil, during the period from 2008 to 2009. The outcome variable "disability" was established based on self-reported problems in body functions or structures. Sociodemographic characteristics ("sex," "age," "skin color," "marital status," "years of schooling," and "family income") and health ("reported morbidity," "health self-assessment," "quality of life," and "life satisfaction") were the explanatory variables...
January 2017: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/28508259/investigation-of-the-scaling-characteristics-of-landsat-temperature-and-vegetation-data-a-wavelet-based-approach
#3
Maheswaran Rathinasamy, V M Bindhu, Jan Adamowski, Balaji Narasimhan, Rakesh Khosa
An investigation of the scaling characteristics of vegetation and temperature data derived from LANDSAT data was undertaken for a heterogeneous area in Tamil Nadu, India. A wavelet-based multiresolution technique decomposed the data into large-scale mean vegetation and temperature fields and fluctuations in horizontal, diagonal, and vertical directions at hierarchical spatial resolutions. In this approach, the wavelet coefficients were used to investigate whether the normalized difference vegetation index (NDVI) and land surface temperature (LST) fields exhibited self-similar scaling behaviour...
May 16, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28508127/transcending-landscapes-working-across-scales-and-levels-in-pastoralist-rangeland-governance
#4
Lance W Robinson, Enoch Ontiri, Tsegaye Alemu, Stephen S Moiko
Landscape approaches can be subjected to mistakenly targeting a single "best" level of governance, and paying too little attention to the role that cross-scale and cross-level interactions play in governance. In rangeland settings, resources, patterns of use of those resources, and the institutions for managing the resources exist at multiple levels and scales. While the scholarship on commons offers some guidance on how to conceptualize governance in rangeland landscapes, some elements of commons scholarship-notably the "design principles" for effective governance of commons-do not seem to apply neatly to governance in pastoralist rangeland settings...
May 15, 2017: Environmental Management
https://www.readbyqxmd.com/read/28507860/aging-and-sexual-differences-of-the-human-skull
#5
Luiz Eduardo Toledo Avelar, Márcio Alberto Cardoso, Leonardo Santos Bordoni, Lorena de Miranda Avelar, João Victor de Miranda Avelar
BACKGROUND: The aging process of the face comprises all layers: skin, subcutaneous fat, muscles, and skeleton, and the signs of aging depend mainly on which layer is mostly affected. OBJECTIVE: To evaluate the aging facial skeleton, as well as establish the sexual differences, areas with a strong predisposition to resorption, and aesthetic repercussion for better treatment approach. METHODS: Skulls from the Forensic Anthropology Department of the Institute of Forensic Medicine of Belo Horizonte, Brazil, were classified according to gender and age group (i...
April 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28500385/assessment-of-the-horizontal-transfer-of-functional-genes-as-a-suitable-approach-for-evaluation-of-the-bioremediation-potential-of-petroleum-contaminated-sites-a-mini-review
#6
REVIEW
Aiyoub Shahi, Bahar Ince, Sevcan Aydin, Orhan Ince
Petroleum sludge contains recalcitrant residuals. These compounds because of being toxic to humans and other organism are of the major concerns. Therefore, petroleum sludge should be safely disposed. Physicochemical methods which are used by this sector are mostly expensive and need complex devices. Bioremediation methods because of being eco-friendly and cost-effective overcome most of the limitations of physicochemical treatments. Microbial strains capable to degrade petroleum hydrocarbons are practically present in all soils and sediments and their population density increases in contact with contaminants...
May 12, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28488744/membrane-vesicle-secretion-and-prophage-induction-in-multidrug-resistant-stenotrophomonas-maltophilia-in-response-to-ciprofloxacin-stress
#7
Simon Devos, Wouter Van Putte, Jolien Vitse, Gonzalez Van Driessche, Stephan Stremersch, Wim Van Den Broek, Koen Raemdonck, Kevin Braeckmans, Henning Stahlberg, Misha Kudryashev, Savvas N Savvides, Bart Devreese
Several bacterial species produce membrane vesicles (MVs) in response to antibiotic stress. However, the biogenesis and role of MVs in bacterial antibiotic resistance mechanisms have remained unclear. Here we studied the effect of the fluoroquinolone ciprofloxacin on MV secretion by Stenotrophomonas maltophilia using a combination of electron microscopy and proteomic approaches. We found that in addition to the classical outer membrane vesicles (OMV), ciprofloxacin-stimulated cultures produced larger vesicles containing both outer and inner membranes termed outer-inner membrane vesicles (OIMV), and that such MVs are enriched with cytosolic proteins...
May 10, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28485926/simultaneous-acquisition-of-the-polarized-and-depolarized-raman-signal-with-a-single-detector
#8
Johannes Kiefer
Polarization-resolved Raman spectroscopy provides much more information than its conventional counterpart. However, it usually either requires a complicated setup with two spectrographs and detectors or two measurements must be performed sequentially. This study presents a simple and straightforward approach to recording both polarization components simultaneously with a single spectrograph and detector. The vertically and a horizontally polarized laser beam exiting a Wollaston prism are focused into the sample with a small spatial separation...
May 16, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28468923/three-dimensional-midwater-camouflage-from-a-novel-two-component-photonic-structure-in-hatchetfish-skin
#9
Eric I Rosenthal, Amanda L Holt, Alison M Sweeney
The largest habitat by volume on Earth is the oceanic midwater, which is also one of the least understood in terms of animal ecology. The organisms here exhibit a spectacular array of optical adaptations for living in a visual void that have only barely begun to be described. We describe a complex pattern of broadband scattering from the skin of Argyropelecus sp., a hatchetfish found in the mesopelagic zone of the world's oceans. Hatchetfish skin superficially resembles the unpolished side of aluminium foil, but on closer inspection contains a complex composite array of subwavelength-scale dielectric structures...
May 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28466825/pure-visual-imagery-as-a-potential-approach-to-achieve-three-classes-of-control-for-implementation-of-bci-in-non-motor-disorders
#10
Teresa Sousa, Carlos Amaral, João Andrade, Gabriel Pires, Urbano Nunes, Miguel Castelo-Branco
OBJECTIVE: The achievement of multiple instances of control with the same type of mental strategy represents a way to improve flexibility of BCI systems. Here we test the hypothesis that pure visual motion imagery of an external actuator can be used as a tool to achieve three classes of EEG based control, which might be useful in attention disorders. APPROACH: We hypothesize that different number of imagined motion alternations lead to distinctive signals, as predicted by distinct motion patterns...
May 3, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28451316/quantitative-self-powered-electrochromic-biosensors
#11
Miguel Aller Pellitero, Anton Guimerà, Maria Kitsara, Rosa Villa, Camille Rubio, Boris Lakard, Marie-Laure Doche, Jean-Yves Hihn, F Javier Del Campo
Self-powered sensors are analytical devices able to generate their own energy, either from the sample itself or from their surroundings. The conventional approaches rely heavily on silicon-based electronics, which results in increased complexity and cost, and prevents the broader use of these smart systems. Here we show that electrochromic materials can overcome the existing limitations by simplifying device construction and avoiding the need for silicon-based electronics entirely. Electrochromic displays can be built into compact self-powered electrochemical sensors that give quantitative information readable by the naked eye, simply controlling the current path inside them through a combination of specially arranged materials...
March 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28439658/pan-genomic-approaches-in-lactobacillus-reuteri-as-a-porcine-probiotic-investigation-of-host-adaptation-and-antipathogenic-activity
#12
Jun-Yeong Lee, Geon Goo Han, Jaeyun Choi, Gwi-Deuk Jin, Sang-Kee Kang, Byung Jo Chae, Eun Bae Kim, Yun-Jaie Choi
After the introduction of a ban on the use of antibiotic growth promoters (AGPs) for livestock, reuterin-producing Lactobacillus reuteri is getting attention as an alternative to AGPs. In this study, we investigated genetic features of L. reuteri associated with host specificity and antipathogenic effect. We isolated 104 L. reuteri strains from porcine feces, and 16 strains, composed of eight strains exhibiting the higher antipathogenic effect (group HS) and eight strains exhibiting the lower effect (group LS), were selected for genomic comparison...
April 24, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28432954/fully-automatic-left-ventricular-segmentation-from-long-axis-cardiac-cine-mr-scans
#13
Rahil Shahzad, Qian Tao, Oleh Dzyubachyk, Marius Staring, Boudewijn P F Lelieveldt, Rob J van der Geest
With an increasing number of large-scale population-based cardiac magnetic resonance (CMR) imaging studies being conducted nowadays, there comes the mammoth task of image annotation and image analysis. Such population-based studies would greatly benefit from automated pipelines, with an efficient CMR image analysis workflow. The purpose of this work is to investigate the feasibility of using a fully-automatic pipeline to segment the left ventricular endocardium and epicardium simultaneously on two orthogonal (vertical and horizontal) long-axis cardiac cine MRI scans...
April 13, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28426805/evidence-of-horizontal-gene-transfer-by-transposase-gene-analyses-in-fervidobacterium-species
#14
Alba Cuecas, Wirojne Kanoksilapatham, Juan M Gonzalez
Horizontal Gene Transfer (HGT) plays an important role in the physiology and evolution of microorganisms above all thermophilic prokaryotes. Some members of the Phylum Thermotogae (i.e., Thermotoga spp.) have been reported to present genomes constituted by a mosaic of genes from a variety of origins. This study presents a novel approach to search on the potential plasticity of Fervidobacterium genomes using putative transposase-encoding genes as the target of analysis. Transposases are key proteins involved in genomic DNA rearrangements...
2017: PloS One
https://www.readbyqxmd.com/read/28425174/costs-and-benefits-of-sublethal-drosophila-c-virus-infection
#15
V Gupta, C O Stewart, S S C Rund, K Monteith, P F Vale
Viruses are major evolutionary drivers of insect immune systems. Much of our knowledge of insect immune responses derives from experimental infections using the fruit fly Drosophila melanogaster. Most experiments, however, employ lethal pathogen doses through septic injury, frequently overwhelming host physiology. While this approach has revealed several immune mechanisms, it is less informative about the fitness costs hosts may experience during infection in the wild. Using both systemic and oral infection routes, we find that even apparently benign, sublethal infections with the horizontally transmitted Drosophila C virus (DCV) can cause significant physiological and behavioural morbidity that is relevant for host fitness...
April 20, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28417201/quantification-of-dynamic-posterior-translation-in-modified-bilateral-alexander-views-and-correlation-with-clinical-and-radiological-parameters-in-patients-with-acute-acromioclavicular-joint-instability
#16
Marvin Minkus, Carmen Hann, Markus Scheibel, Natascha Kraus
INTRODUCTION: Classification of AC-joint instability is based on radiologic evaluation of anteroposterior (a.p.) stress views of both shoulders, neglecting the horizontal component of instability. Recent studies have proposed an association of dynamic posterior translation (DPT) and inferior clinical results. The purpose of this study was to quantify DPT in modified Alexander views and correlate it with other radiological and clinical data. MATERIALS AND METHODS: Thirty-two patients (4 f, 28 m, mean age 34...
April 17, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/28409726/the-suboccipital-ligament
#17
Kelsey Alabaster, M Fred Bugg, Bruno Splavski, Frederick A Boop, Kenan I Arnautovic
OBJECTIVE A fibrous structure located dorsal to the dura at the posterior craniocervical junction stretches horizontally between the bilateral occipital condyles and the upper borders of the C-1 laminae. Partially covered by the occipital bone, this structure is always encountered when the bone is removed from the foramen magnum rim during approaches to the posterior cranial fossa. Although known to surgeons, this structure has not been defined, studied, or named. The most appropriate name for this structure is "the suboccipital ligament," and a detailed rationale for this name is provided...
April 14, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28405268/revisiting-the-phylogeny-of-wolbachia-in-collembola
#18
Yao Ma, Wan-Jun Chen, Zhao-Hui Li, Feng Zhang, Yan Gao, Yun-Xia Luan
The endosymbiont Wolbachia has been detected in a few parthenogenetic collembolans sampled in Europe and America, including three species of Poduromorpha, two species of Entomobryomorpha, and two species of Neelipleona. Based on 16S rRNA and ftsZ gene sequences, most of the Wolbachia infecting parthenogenetic collembolans were characterized as members of supergroup E and showed concordant phylogeny with their hosts. However, the two neelipleonan symbionts form another unique group, indicating that Wolbachia has infected parthenogenetic collembolans multiple times...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28403303/the-game-as-strategy-for-approach-to-sexuality-with-adolescents-theoretical-methodological-re%C3%AF-ections
#19
Vânia de Souza, Maria Flávia Gazzinelli, Amanda Nathale Soares, Marconi Moura Fernandes, Rebeca Nunes Guedes de Oliveira, Rosa Maria Godoy Serpa da Fonseca
OBJECTIVE: To describe the Papo Reto [Straight Talk] game and reflect on its theoretical-methodological basis. METHOD: Analytical study on the process of elaboration of the Papo Reto online game, destined to adolescents aged 15-18 years, with access to the Game between 2014 and 2015. RESULTS: the interactions of 60 adolescents from Belo Horizonte and São Paulo constituted examples of the potentialities of the Game to favor the approach to sexuality with adolescents through simulation of reality, invention and interaction...
April 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28402354/simultaneous-ridge-augmentation-and-accelerated-molar-uprighting-for-implant-site-development-two-case-reports-with-a-split-mouth-design
#20
Chin-Wei Wang, Michelle Yuching Chou, Rebecca Chen, Todd Rowe, Mohamed Masoud, David M Kim, Giuseppe Intini
Well-coordinated interdisciplinary dental treatments provide the best esthetic, functional, and long-term results for patients. However, the length of such treatment, which may involve orthodontics, ridge augmentation, and dental implants, often deters patients from pursuing them. The two case reports presented here aim to present the advantage of simultaneous orthodontic molar uprighting and ridge augmentation procedures for future implant site development. Selective decortication of the alveolar bone, performed simultaneously with bone grafting, can accelerate the tooth uprighting process and synergistically reduce treatment duration...
May 2017: International Journal of Periodontics & Restorative Dentistry
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