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Horizontal approach

Kevin C Cossel, Eleanor M Waxman, Fabrizio R Giorgetta, Michael Cermak, Ian R Coddington, Daniel Hesselius, Shalom Ruben, William C Swann, Gar-Wing Truong, Gregory B Rieker, Nathan R Newbury
We demonstrate a new technique for spatial mapping of multiple atmospheric gas species. This system is based on high-precision dual-comb spectroscopy to a retroreflector mounted on a flying multi-copter. We measure the atmospheric absorption over long open-air paths to the multi-copter with comb-tooth resolution over 1.57 to 1.66 pm, covering absorption bands of CO2 , Cm, H2 O and isotopologues. When combined with GPS-based path length measurements, a fit of the absorption spectra retrieves the dry mixing ratios versus position...
July 20, 2017: Optica
Ying-Chun Zhang, Tai-Sheng Chen, Hua Zhu
OBJECTIVE: To explore the early clinical effect and safety of percutaneous transforaminal endoscopic technology for cervical spondylotic radiculopathy. METHODS: From August 2016 to September 2017, 14 patients with cervical spondylotic radiculopathy who responded poorly to non-surgical treatment for at least 6 weeks underwent percutaneous transforaminal endoscopic discectomy via posterior approach. There were 6 males and 8 females, aging from 32 to 68 years old with an average of (40...
April 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
Germain Chevignon, Georges Periquet, Gabor Gyapay, Nathalie Vega-Czarny, Karine Musset, Jean-Michel Drezen, Elisabeth Huguet
Polydnaviruses (PDVs) are essential for the parasitism success of tens of thousands of species of parasitoid wasps. PDVs are present in wasp genomes as proviruses, which serve as template for the production of double stranded circular viral DNA carrying virulence genes that are injected into lepidopteran hosts. PDV circles do not contain genes coding for particle production hence impeding viral replication in caterpillar hosts during parasitism. Here we investigated the fate of PDV circles of Cotesia congregata bracovirus during parasitism of the tobacco hornworm, Manduca sexta , by the wasp Cotesia congregata Sequences sharing similarities with Host integration Motifs (HIM) involved in integration into DNA of Microplitis demolitor bracovirus (MdBV) circles, could be identified in 12 CcBV circles, which encode PTP and VANK gene families involved in host immune disruption...
May 16, 2018: Journal of Virology
Mayank Goyal, Aravind Ganesh, Scott Brown, Bijoy K Menon, Michael D Hill
The modified Rankin Scale (mRS) at 90 days after stroke onset has become the preferred outcome measure in acute stroke trials, including recent trials of interventional therapies. Reporting the range of modified Rankin Scale scores as a paired horizontal stacked bar graph (colloquially known as "Grotta bars") has become the conventional method of visualizing modified Rankin Scale results. Grotta bars readily illustrate the levels of the ordinal modified Rankin Scale in which benefit may have occurred...
January 1, 2018: International Journal of Stroke: Official Journal of the International Stroke Society
Kyo Koizumi, Masatoshi Inoue, Srikanta Chowdhury, Haruhiko Bito, Akihiro Yamanaka, Toru Ishizuka, Hiromu Yawo
To investigate how the functional architecture is organized in layer 5 (L5) of the somatosensory cortex of a mouse in vivo, the input-output relationship was investigated using an all-optical approach. The neural activity in L5 was optically recorded using a Ca2+ sensor, R-CaMP2, through a microprism inserted in the cortex under two-photon microscopy, while the L5 was regionally excited using optogenetics. The excitability was spread around the blue-light irradiated region, but the horizontal propagation was limited to within a certain distance (λ < 130 μm from the center of the illumination spot)...
May 14, 2018: Journal of Physiological Sciences: JPS
Kata Bölcskei, Gábor Kriszta, Éva Sághy, Maja Payrits, Éva Sipos, Anett Vranesics, Zoltán Berente, Hajnalka Ábrahám, Péter Ács, Sámuel Komoly, Erika Pintér
We have recently reported that the Transient Receptor Potential Ankyrin 1 (TRPA1) receptor deficiency significantly attenuated cuprizone-induced demyelination by reducing the apoptosis of mature oligodendrocytes. The aim of the present study was to gather additional data on the role of TRPA1 by investigating the time course of behavioural alterations and morphological changes in cuprizone-treated TRPA1 receptor gene-deficient mice. Demyelination was induced by feeding male wild-type (WT) and TRPA1 gene-deleted (TRPA1 KO) mice with 0...
July 15, 2018: Journal of Neuroimmunology
Tian Guan, Xiangnan Wang, Dongmei Li, Yilong Zhang, Yonghong He, Lixuan Shi, Yiqing Liu, Yuxuan Yang, Yang Xu, Rui Cui
A phase-sensitive weak measurement biosensor was proposed for the detection of carcinoembryonic antigen (CEA), one common category of tumor markers. The total internal reflection (TIR) at the interface of the prism without precious metal coating was exploited to introduce the phase delay between horizontal and vertical polarizations, which can be determined through the central wavelength shift of output spectra for the sensing of the refractive index of the sample. In the weak measurement analysis, the specific binding reaction of tumor markers with a refractive index change on the surface of the prism can be monitored in real time through the central wavelength shift...
May 14, 2018: Sensors
Giovanni Succo, Erika Crosetti, Andy Bertolin, Cesare Piazza, Gabriele Molteni, Stefano Cirillo, Massimo Petracchini, Martina Tascone, Andrea Elio Sprio, Giovanni Nicolao Berta, Giorgio Peretti, Livio Presutti, Giuseppe Rizzotto
BACKGROUND: The purpose of this retrospective study was to identify subcategories in cT3 to cT4a supraglottic/glottic cancers, describing their different spreading patterns, and local and locoregional recurrence modes. METHODS: Four hundred eighty-nine patients who underwent open partial horizontal laryngectomies (OPHLs) were retrospectively classified as: subcategory I (anterior pT3 with normal arytenoid mobility); subcategory II (posterior pT3 with impaired/absent mobility); subcategory III (anterior pT4 with normal mobility); and subcategory IV (posterior pT4 with impaired/absent mobility)...
May 13, 2018: Head & Neck
Yves Lafort, Letitia Greener, Faustino Lessitala, Sophie Chabeda, Ross Greener, Mags Beksinska, Peter Gichangi, Sally Griffin, Jenni A Smit, Matthew Chersich, Wim Delva
OBJECTIVES: To enhance uptake of sexual and reproductive health (SRH) services by female sex workers (FSWs), we conducted an implementation study in which we piloted and tested context-specific 'diagonal' interventions, combining vertical, targeted interventions with horizontally improved access to the general health services, in three cities in sub-Saharan Africa. METHODS: We collected indicators of SRH service uptake through face-to-face interviews with approximately 400 FSWs, pre- and post-intervention, in Durban, South Africa; Tete, Mozambique; and Mombasa, Kenya, recruited by respondent-driven sampling...
May 12, 2018: Tropical Medicine & International Health: TM & IH
André S Santos, Rommel T Ramos, Artur Silva, Raphael Hirata, Ana L Mattos-Guaraldi, Roberto Meyer, Vasco Azevedo, Liza Felicori, Luis G C Pacheco
Biochemical tests are traditionally used for bacterial identification at the species level in clinical microbiology laboratories. While biochemical profiles are generally efficient for the identification of the most important corynebacterial pathogen Corynebacterium diphtheriae, their ability to differentiate between biovars of this bacterium is still controversial. Besides, the unambiguous identification of emerging human pathogenic species of the genus Corynebacterium may be hampered by highly variable biochemical profiles commonly reported for these species, including Corynebacterium striatum, Corynebacterium amycolatum, Corynebacterium minutissimum, and Corynebacterium xerosis...
May 11, 2018: Functional & Integrative Genomics
Bo Song, Qin Zhou, Hai-Jie Xue, Jia-Jia Liu, Yuan-Yuan Zheng, Yan-Bing Shen, Min Wang, Jian-Mei Luo
During steroid bioconversion, organic solvents are widely used for facilitating hydrophobic substrate dissolution in industry. Thus, strains that tolerate organic solvents are highly desirable. IrrE, a global transcriptional factor, was introduced into Arthrobacter simplex with Δ1 -dehydrogenation ability. The results evidenced that IrrE did not affect cell biological traits and biotransformation performance under non-stress conditions. However, the recombinant strain achieved a productivity higher than that of the control strain in systems containing more ethanol and substrate, which coincided with cell viability under ethanol stress, the major stress factor during biotransformation...
May 10, 2018: Journal of Agricultural and Food Chemistry
Daniele L Marchisio, Miquel Galan, Antonello A Barresi
This manuscript shows how computational models, mainly based on Computational Fluid Dynamics (CFD), can be used to simulate different parts of an industrial freeze-drying equipment and to properly design them; in particular in this part the duct connecting the chamber with the condenser, with its valves, is considered, while the chamber design and its effect on drying kinetics have been investigated in Part 1. Such an approach allows a much deeper process understanding and assessment of the critical aspects of lyophilisation...
May 5, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Frank Anayo Orji, Ositadinma Chinyere Ugbogu, Eziuche Amadike Ugbogu, Alberto Barbabosa-Pliego, Jose Cedillo Monroy, Abdelfattah Z M Salem
Over 250 species of resident flora in the class of bacteria are known to be associated with humans. These conventional flora compositions is often determined by factors which may not be limited to stress, nutrition, genetics, and age, sex, stress, nutrition of humans. Man is constantly in contact with bacteria through media such as air, water, soil and food. This paper reviews the concept of bacterial pathogenesis from the sequential point of colonization to tissue injury. The paper in addition to examination of the factors which enhances virulence in bacterial pathogens also x-rayed the concept of pathogenicity islands and the next generation approaches or rather current trends/methods used in the bacterial pathogenicity investigations...
May 5, 2018: Microbial Pathogenesis
Mohammad H Al-Shayyab
PURPOSE: The mandibular foramen (MF) cannot be palpated clinically and its location is variable at the medial surface of mandibular ramus. Nevertheless, determining its exact location is very important to the oral and maxillofacial surgeon for the relevant anesthetic and surgical ramus procedures. The aim of this study was to analyze the position of MF using cone-beam computed tomography (CBCT) to help the surgeon in identifying reliable 'target area' for the inferior alveolar nerve (IAN) block and 'safety zone' for mandibular ramus osteotomies approached extra-orally...
May 8, 2018: Surgical and Radiologic Anatomy: SRA
Bomi Kim, Hyung-Chul Lee, Seong-Hun Kim, Yongil Kim, Woosung Son, Seong Sik Kim
Objective: This study examined cone-beam computed tomography (CBCT)-derived multiplanar-reconstructed (MPR) cross-sections to clarify the salient characteristics of patients with skeletal class III malocclusion with midface deficiency (MD). Methods: The horizontal and sagittal plane intersection points were identified for middle-third facial analysis in 40 patients in the MD or normal (N) groups. MPR images acquired parallel to each horizontal plane were used for length and angular measurements...
May 2018: Korean Journal of Orthodontics
Alexander Antoniadis, Dimitris Dimitriou, Andreas Flury, Gregor Wiedmer, Julian Hasler, Naeder Helmy
BACKGROUND: Severely obese patients present a significant challenge for arthroplasty surgeons because of their body habitus. Up to date, there is no clear consensus on the safety of the direct anterior approach (DAA) in obese patients undergoing total hip arthroplasty. Therefore, the purpose of the present study was to determine whether DAA is a credible option in severely obese regarding complication rates, clinical outcomes, and component positioning. METHODS: Obese patients with a body mass index ≥ 35 kg/m2 (n = 129) who received total hip arthroplasty with DAA in our institution were matched for gender and age with nonobese patients with body mass index ≤ 25 kg/m2 (n = 125)...
April 11, 2018: Journal of Arthroplasty
Ania T Deutscher, Catherine M Burke, Aaron E Darling, Markus Riegler, Olivia L Reynolds, Toni A Chapman
BACKGROUND: Gut microbiota affects tephritid (Diptera: Tephritidae) fruit fly development, physiology, behavior, and thus the quality of flies mass-reared for the sterile insect technique (SIT), a target-specific, sustainable, environmentally benign form of pest management. The Queensland fruit fly, Bactrocera tryoni (Tephritidae), is a significant horticultural pest in Australia and can be managed with SIT. Little is known about the impacts that laboratory-adaptation (domestication) and mass-rearing have on the tephritid larval gut microbiome...
May 5, 2018: Microbiome
Hafiz S Patwa, Juan C Yanez-Siller, Matias Gomez Galarce, Bradley A Otto, Daniel M Prevedello, Ricardo L Carrau
OBJECTIVES/HYPOTHESIS: To demonstrate anatomic relationships of the far-medial transoral endoscopic assisted approach (FMT-EAA) to the infratemporal fossa (ITF) and define the corridor dimensions, surgical freedom, and limitations associated with this approach. STUDY DESIGN: Cadaveric study. METHODS: Twenty ITFs (10 specimens) were dissected with the assistance of 0 °, 30 °, and 45 ° rod-lens endoscopes. Image guidance was used to confirm and measure the corridors' structural boundaries and document the anatomical relationships encountered in this approach...
May 4, 2018: Laryngoscope
Andrew R Scott, Kofi D Boahene
We present a novel method for columellar reconstruction using a hidden donor site and review the challenges and limitations of columellar reconstruction in children with Fitzpatrick VI skin type. A staged reconstruction was conceived in which a full-thickness skin graft was transferred to the superior gingivolabial sulcus in the area of the maxillary frenulum. Six months later, the prelaminated soft tissue flap was delivered through a horizontal incision at the subnasale, and the donor site closed primarily...
May 4, 2018: Laryngoscope
Juan C Cendán, Oloruntomi Joledo, Mary Beth Soborowicz, Leslie Marchand, Basma R Selim
PROBLEM: Interruptions in academic progress (IP) are problematic for both the student and the educational program. Early identification of students at risk for IP, so as to provide remediation, could be beneficial. APPROACH: Considering the clinically familiar pediatric growth curve as a metaphor, researchers hypothesized they could identify students at risk of IP. They organized course-related examination performance data for 518 students in five classes (2013-14 through 2017-18), adding students' percent scores cumulatively over time...
May 2, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
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