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https://www.readbyqxmd.com/read/28109186/interleukin-1-as-a-mediator-of-fatigue-in-disease-a-narrative-review
#1
REVIEW
Megan E Roerink, Marieke E van der Schaaf, Charles A Dinarello, Hans Knoop, Jos W M van der Meer
Fatigue is commonly reported in a variety of illnesses, and it has major impact on quality of life. Previously, it was thought that fatigue originates in the skeletal muscles, leading to cessation of activity. However, more recently, it has become clear that the brain is the central regulator of fatigue perception. It has been suggested that pro-inflammatory cytokines, especially interleukin-1 alpha (IL-1α) and interleukin-1 beta (IL-1β), play a prominent role in the development of central fatigue, and several studies have been performed to elucidate the connection between inflammation and these central processes...
January 21, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28109168/integrated-omics-analysis-of-specialized-metabolism-in-medicinal-plants
#2
Amit Rai, Kazuki Saito, Mami Yamazaki
Medicinal plants are the rich source of highly diverse specialized metabolites with important pharmacological properties. Until recently, plant biologists were limited in their approach to explore biosynthetic pathways of these metabolites, mainly due to the scarcity of plant genomics resources. Recent advancements in the high-throughput large-scale analytical methods have enabled plant biologists to discover biosynthetic pathways for important plant-based medicinal metabolites. Reduced cost to generate omics datasets, and the development of computational tools for their analysis and integration have led to the elucidation of biosynthetic pathways of several plant origin bio-active metabolites...
January 21, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28109162/odontoblastic-differentiation-of-dental-pulp-stem-cells-from-healthy-and-carious-teeth-on-an-original-pcl-based-3d-scaffold
#3
A Louvrier, E Euvrard, L Nicod, G Rolin, F Gindraux, L Pazart, C Houdayer, P Y Risold, F Meyer, C Meyer
AIMS: To isolate and characterize Dental Pulp Stem Cells (DPSCs) obtained from carious and healthy mature teeth extracted when conservative treatment was not possible or for orthodontic reasons; to evaluate the ability of DPSCs to colonize, proliferate, and differentiate into functional odontoblast-like cells when cultured onto a polycaprolactone cone made by jet-spraying and prototyped into a design similar to a gutta-percha cone. METHODOLOGY: DPSCs were obtained from 9 carious and 12 healthy mature teeth...
January 21, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28109062/fibroblasts-as-maestros-orchestrating-tissue-regeneration
#4
REVIEW
Raquel Costa-Almeida, Raquel Soares, Pedro L Granja
Fibroblasts constitute a dynamic and versatile population of cells of mesenchymal origin, implicated in both regenerative strategies and pathological conditions. Despite being frequently associated to disease development, particularly through the establishment of fibrotic tissue, fibroblasts hold great potential for tissue engineering and regenerative medicine applications. They are responsible for synthesizing and depositing extracellular matrix components, allowing other cells to settle and migrate along a three-dimensional support and thereby generating an organ-specific architecture...
January 20, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28109049/production-of-the-antibiotic-secondary-metabolite-solanapyrone-a-by-the-fungal-plant-pathogen-ascochyta-rabiei-during-fruiting-body-formation-in-saprobic-growth
#5
Wonyong Kim, Jeong-Jin Park, Frank M Dugan, Tobin L Peever, David R Gang, George Vandemark, Weidong Chen
Fungi are noted producers of a diverse array of secondary metabolites, many of which are of pharmacological importance. However, the biological roles of the vast majority of these molecules during the fungal life cycle in nature remain elusive. Solanapyrones are polyketide-derived secondary metabolites produced by diverse fungal species including the plant pathogen Ascochyta rabiei. This molecule was originally thought to function as a phytotoxin facilitating pathogenesis of A. rabiei. Chemical profiling and gene expression studies showed that solanapyrone A was specifically produced during saprobic, but not parasitic growth of A...
January 21, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28109013/investigation-of-genetic-defects-in-severe-combined-immunodeficiency-patients-from-turkey-by-targeted-sequencing
#6
Baran Erman, Ivan Bilic, Tatjana Hirschmugl, Elisabeth Salzer, Heidrun Boztug, Özden Sanal, Deniz Çağdaş Ayvaz, Ilhan Tezcan, Kaan Boztug
Primary immunodeficiencies (PIDs) represent a large group of disorders with an increased susceptibility to infections. Severe combined immunodeficiency (SCID) is the most severe form of primary immunodeficiencies (PIDs) with marked T-cell lymphopenia. Investigation of the genetic etiology using classical Sanger sequencing is associated with considerable diagnostic delay. We here established a custom-designed, next generation sequencing-based panel to efficiently identify disease-causing genetic defects in PID patients and applied this method in SCID patients of Turkish origin with previously undefined genetic etiology...
January 21, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28108896/pharmacophore-based-screening-and-drug-repurposing-exemplified-on-glycogen-synthase-kinase-3-inhibitors
#7
Luminita Crisan, Sorin Avram, Liliana Pacureanu
The current study was conducted to elaborate a novel pharmacophore model to accurately map selective glycogen synthase kinase-3 (GSK-3) inhibitors, and perform virtual screening and drug repurposing. Pharmacophore modeling was developed using PHASE on a data set of 203 maleimides. Two benchmarking validation data sets with focus on selectivity were assembled using ChEMBL and PubChem GSK-3 confirmatory assays. A drug repurposing experiment linking pharmacophore matching with drug information originating from multiple data sources was performed...
January 21, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28108843/ets-transcription-factors-etv2-and-fli1b-are-required-for-tumor-angiogenesis
#8
Kristina Baltrunaite, Michael P Craig, Sharina Palencia Desai, Praneet Chaturvedi, Ram Naresh Pandey, Rashmi S Hegde, Saulius Sumanas
ETS transcription factor ETV2/Etsrp functions as a key regulator of embryonic vascular development in multiple vertebrates. However, its role in pathological vascular development has not been previously investigated. To analyze its role in tumor angiogenesis, we utilized a zebrafish xenotransplantation model. Using a photoconvertible kdrl:NLS-KikGR line, we demonstrated that all tumor vessels originate from the existing embryonic vasculature by the mechanism of angiogenesis. Xenotransplantation of mouse B16 melanoma cells resulted in a significant increase in expression of the ETS transcription factors etv2 and fli1b expression throughout the embryonic vasculature...
January 20, 2017: Angiogenesis
https://www.readbyqxmd.com/read/28108842/genetic-analysis-of-the-m2-anxa5-haplotype-as-recurrent-pregnancy-loss-predisposition-in-the-malay-population
#9
Kai-Cheen Ang, Sushilnathan Kathirgamanathan, Ewe Seng Ch'ng, Yan-Yeow Lee, Anna-Liza Roslani, Bavanandan Naidu, Krishna Kumar, Ridzuan Abdullah, Siti-Nadiah Abdul Kadir, Narazah Mohd Yusoff, Wan Zaidah Abdullah, Nadja Bogdanova, Peter Wieacker, Arseni Markoff, Thean-Hock Tang
PURPOSE: The aim of this study was to evaluate a new predisposition factor, M2/ANXA5 (RPRGL3), in recurrent pregnancy loss (RPL) patients of Malay origin, since it was previously known that the prevalence of this condition is relatively high among the Malay population of Malaysia, where conventional hereditary thrombophilia factors have been generally ruled out. METHODS: A total of 232 women who had experienced ≥2 unexplained RPL and 141 available male partners were recruited, with 360 healthy Malay and 166 parous female controls...
January 20, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28108792/numerical-magnitude-affects-online-execution-and-not-planning-of-visuomotor-control
#10
Gal Namdar, Tzvi Ganel
Recent literature has established a directional influence of irrelevant numerical magnitude on actions performed toward neutral objects. For example, fingers' aperture during grasping is larger when associated with large compared with small numerical digits. This interaction between symbolic magnitude and visuomotor control has been attributed to the planning stage of the action prior to motor execution. However, this assumption has not been directly tested. In two experiments, we tested whether the effects of numerical magnitude on grasping derive from action planning or from action execution...
January 20, 2017: Psychological Research
https://www.readbyqxmd.com/read/28108775/-injection-therapy-for-cervical-and-lumbar-syndromes
#11
J Grifka, A Benditz, D Boluki
In cervical and lumbar pain syndromes special injections are key for effective pain therapy. Depending on the origin of pain injections are placed at the nerve root or the joints. Thus, the vicious cycle can be stopped. A correct technical procedure is of enormous importance. Because pharmacological effects and special complications are possible, monitoring and precautions are mandatory.
January 20, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28108500/ophthalmic-artery-occlusion-after-pipeline-embolization-device-placement-with-reconstitution-of-flow-via-an-endoleak-a-report-of-two-cases
#12
Michael L Adix, Ian A Kaminsky, In Sup Choi
The Pipeline Embolization Device (PED) is a flow diverting stent used in the treatment of a wide variety of intracranial aneurysms. The device differs from traditional stents used in stent-assisted coil embolization in that it has a tighter lattice structure with smaller cell sizes designed specifically to disrupt blood flow into aneurysms rather than only to retain coils within aneurysms. While the PED has been shown to be safe and effective, it has a unique risk profile that includes side branch and perforator vessel occlusion...
January 20, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28108424/clinical-and-radiological-findings-after-multilevel-cervical-total-disc-replacement-defining-radiological-changes-to-predict-surgical-outcomes
#13
Jung Hwan Lee, Sang-Ho Lee, Jun Ho Lee
OBJECTIVE: This study compared the radiological parameters between preoperation and postoperation for patients who underwent multilevel cervical total disc replacement (MCTDR) and assessed which parameters were related to successful clinical outcomes after MCTDR. METHODS: The study included a consecutive series of 24 patients who were treated with MCTDR following the diagnosis of multilevel cervical disc herniation or stenosis. Numeric Rating Scale (NRS), C2-7 sagittal vertical axis (SVA), range of motion (ROM) of C2-7 segment and TDR implanted levels were evaluated at pre- and post-TDR...
January 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28108406/berry-s-ligament-and-the-inferior-thyroid-artery-as-reliable-anatomical-landmarks-for-the-recurrent-laryngeal-nerve-a-fresh-cadaveric-study-of-the-cervical-spine-the-recurrent-laryngeal-nerve-rln-relevant-to-spine
#14
Ali Rajabian, Michael Walsh, Nasir A Quraishi
BACKGROUND CONTEXT: Whilst most cadaveric studies of the RLN have focused on course variations, they have usually been done on preserved (fixed and embalmed) cadavers which renders the RLN immobile and of less surgical landmark value. PURPOSE: Our aim was to perform a thorough exposure in fresh cadavers with the intention of investigating inferior thyroid artery and Berry's ligament as reliable landmarks for the identification of the RLN in anterior cervical spine surgery...
January 17, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28108391/diversity-of-the-subspecies-bifidobacterium-animalis-subsp-lactis
#15
Vera Bunesova, Jiri Killer, Barbora Javurkova, Eva Vlkova, Vaclav Tejnecky, Sarka Musilova, Vojtech Rada
Strains of Bifidobacterium animalis subsp. lactis are well-known health-promoting probiotics used commercially. B. animalis subsp. lactis has been isolated from different sources, and little is known about animal isolates of this taxon. The aim of this study was to examine the genotypic and phenotypic diversity between B. animalis subsp. lactis strains different animal hosts including Cameroon sheep, Barbary sheep, okapi, mouflon, German shepard) and to compare to BB12, food isolates and the collection strain DSM 10140...
January 17, 2017: Anaerobe
https://www.readbyqxmd.com/read/28108248/a-new-efficient-method-of-generating-photoaffinity-beads-for-drug-target-identification
#16
Yoichi Nishiya, Tomoko Hamada, Masayuki Abe, Michio Takashima, Kyoko Tsutsumi, Katsuya Okawa
Affinity purification is one of the most prevalent methods for the target identification of small molecules. Preparation of an appropriate chemical for immobilization, however, is a tedious and time-consuming process. A decade ago, a photoreaction method for generating affinity beads was reported, where compounds are mixed with agarose beads carrying a photoreactive group (aryldiazirine) and then irradiated with ultraviolet light under dry conditions to form covalent attachment. Although the method has proven useful for identifying drug targets, the beads suffer from inefficient ligand incorporation and tend to shrink and aggregate, which can cause nonspecific binding and low reproducibility...
January 10, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28108205/modifying-the-phenotypic-frailty-model-in-predicting-risk-of-major-osteoporotic-fracture-in-the-elderly
#17
Guowei Li, Alexandra Papaioannou, Lehana Thabane, Mitchell A H Levine, George Ioannidis, Andy K O Wong, Arthur Lau, Jonathan D Adachi
INTRODUCTION: The phenotypic frailty (PF) model (including slow walking, low physical activity, exhaustion, weakness, and unintentional weight loss) has been widely used to quantify the degree of frailty and predict risks of adverse health outcomes for the elderly. However, evidence has shown that not all the components included in the PF model contribute equally, and low predictive accuracy of the PF model has been reported in predicting risks of outcomes. We aimed to improve predictive accuracy of the PF model in risk of major osteoporotic fracture (MOF) in the elderly by modifying its weighting of individual components...
January 17, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28108130/contribution-of-sociodemographic-and-lifestyle-related-factors-to-the-differences-in-metabolic-syndrome-among-russian-somali-and-kurdish-migrants-compared-with-finns
#18
N Skogberg, T Laatikainen, A Jula, T Härkänen, E Vartiainen, P Koponen
BACKGROUND: Metabolic syndrome (MetS) is associated with a substantially increased risk for cardiovascular disease and diabetes. We examined the contribution of length of residence, socioeconomic position and lifestyle-related factors to the differences in the prevalence of MetS among migrants compared with Finns. METHODS: Cross-sectional data from randomly sampled 30-64year-old health examination participants (318 Russian, 212 Somali, and 321 Kurdish origin migrants) of the Migrant Health and Wellbeing Survey (2010-2012) were used...
January 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28108093/source-apportionment-of-lead-in-the-blood-of-women-of-reproductive-age-living-near-tailings-in-taxco-guerrero-mexico-an-isotopic-study
#19
Analine Berenice Vázquez Bahéna, Oscar Talavera Mendoza, Ma Elena Moreno Godínez, Sergio Adrián Salgado Souto, Joaquín Ruiz, Gerardo Huerta Beristain
The concentration and isotopic composition of lead in the blood of forty seven women of reproductive age (15-45y) exposed to multiple sources in two rural communities of the mining region of Taxco, Guerrero in southern Mexico were determined in order to identify specific contributing sources and their apportionment and to trace probable ingestion pathways. Our data indicate that >36% of the studied women have blood lead concentrations above 10μgdL(-1) and up to 87% above 5μgdL(-1). Tailings contain between 2128 and 5988mgkg(-1) of lead and represent the most conspicuous source in the area...
January 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28108045/a-comparison-of-3-on-line-nomograms-with-the-detection-of-primary-circulating-prostate-cells-to-predict-prostate-cancer-at-initial-biopsy
#20
N P Murray, C Fuentealba, E Reyes, O Jacob
INTRODUCTION: The use of nomograms which include the PSA may improve the predictive power of obtaining a prostate biopsy (PB) positive for cancer. We compare the use of three on-line nomagrams with the detection of primary malignant circulating prostate cells (CPCs) to predict the results of an initial PB in men with suspicion of prostate cancer. METHODS AND PATIENTS: Consecutive men with suspicion of prostate cancer underwent a 12 core TRUS prostate biopsy; age, total serum PSA, percent free PSA, family history, ethnic origin and prostate ultrasound results were used for risk assessment using the online nomograms...
January 17, 2017: Actas Urologicas Españolas
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