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Dutasteride alopecia

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https://www.readbyqxmd.com/read/27789379/a-new-label-free-screen-for-steroid-5%C3%AE-reductase-inhibitors-using-lc-ms
#1
Jukkarin Srivilai, Karma Rabgay, Nantaka Khorana, Neti Waranuch, Nitra Nuengchamnong, Kornkanok Ingkaninan
Steroid 5α-reductase (S5αR) plays an important role in metabolizing testosterone into active androgen dihydrotestosterone (DHT) which is involved in many androgen dependent disorders, such as androgenic alopecia, benign prostatic hyperplasia and acne. The method for screening for S5αR inhibition is key in finding new antagonists. In this study, the label-free S5αR inhibitory assay using LC-MS was developed. S5αR type 1 enzyme was obtained from LNCaP prostate cancer cells. The enzymatic assay was optimised for enzyme-substrate (testosterone) concentration, NADPH-cofactor concentration, solvent tolerance, enzyme activity stability and incubation time...
October 24, 2016: Steroids
https://www.readbyqxmd.com/read/27659058/risk-of-erectile-dysfunction-associated-with-use-of-5-%C3%AE-reductase-inhibitors-for-benign-prostatic-hyperplasia-or-alopecia-population-based-studies-using-the-clinical-practice-research-datalink
#2
Katrina Wilcox Hagberg, Hozefa A Divan, Rebecca Persson, J Curtis Nickel, Susan S Jick
OBJECTIVE:  To estimate the risk of erectile dysfunction in men who used 5-α reductase inhibitors to treat benign prostatic hyperplasia or alopecia. DESIGN:  Cohort studies with nested case-control analyses. SETTING:  UK Clinical Practice Research Datalink. POPULATION:  Two populations of men free of risk factors for erectile dysfunction and other sexual dysfunction or its treatment: men aged 40 or more with benign prostatic hyperplasia who received a prescription for a 5-α reductase inhibitor (finasteride or dutasteride) or α blocker, or both, and men aged 18-59 with alopecia...
September 22, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27549867/superiority-of-dutasteride-over-finasteride-in-hair-regrowth-and-reversal-of-miniaturization-in-men-with-androgenetic-alopecia-a-randomized-controlled-open-label-evaluator-blinded-study
#3
Sujit J S Shanshanwal, Rachita S Dhurat
BACKGROUND: Finasteride and dutasteride are inhibitors of the enzyme 5-alpha-reductase which inhibits the conversion of testosterone to dihydrotestosterone. Dutasteride inhibits both type I and type II 5-alpha-reductase while finasteride inhibits only the type II enzyme. As both isoenzymes are present in hair follicles, it is likely that dutasteride is more effective than finasteride. AIMS: To compare the efficacy, safety and tolerability of dutasteride and finasteride in men with androgenetic alopecia...
August 22, 2016: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/27489426/safety-and-tolerability-of-the-dual-5-alpha-reductase-inhibitor-dutasteride-in-the-treatment-of-androgenetic-alopecia
#4
Gwang Seong Choi, Joon Hyung Kim, Shin-Young Oh, Jung-Min Park, Ji-Soo Hong, Yil-Seob Lee, Won-Soo Lee
BACKGROUND: After the approval of dutastride for androgenic alopecia (AGA) in 2009, Korean authority required a post-marketing surveillance to obtain further data on its safety profile. OBJECTIVE: The objective was to monitor adverse events (AEs) of dutasteride 0.5 mg in Korean AGA male patients in a clinical practice environment. METHODS: Open label, multi-center, non-interventional observational study was done from July 2009 to July 2013...
August 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27475241/effect-of-5%C3%AE-reductase-inhibitors-on-sexual-function-a-meta-analysis-and-systematic-review-of-randomized-controlled-trials
#5
REVIEW
Luhao Liu, Shankun Zhao, Futian Li, Ermao Li, Ran Kang, Lianmin Luo, Jintai Luo, Shawpong Wan, Zhigang Zhao
INTRODUCTION: 5α-Reductase inhibitors (5ARIs) are widely used for the treatment of benign prostatic hyperplasia (BPH) and androgenetic alopecia (AGA). AIM: To review all the available data on the effect of 5ARIs on sexual function and assess whether 5ARIs increase the risk of sexual dysfunction. METHODS: A systematic search of the literature was conducted using the Medline, Embase, and Cochrane databases. The search was limited to articles published in English and up to October 2015...
September 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27298504/atypical-post-finasteride-syndrome-a-pharmacological-riddle
#6
Anita K Gupta, Neetu Sharma, Prashant Shukla
Finasteride and dutasteride are commonly used 5-alpha reductase inhibitors. While finasteride is a selective inhibitor of 5-alpha reductase Type II, dutasteride inhibits 5- alpha reductase Type I and II. The United States Food and Drug Administration approved the use of finasteride for benign prostatic hypertrophy (BPH) as well as androgenic alopecia (AGA) while dutasteride is approved only for BPH. Off-label use of dutasteride is not uncommon in AGA as well. Although the postfinasteride syndrome (PFS) is a well-established entity, its symptomatology is quite variable...
May 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27273740/familial-frontal-fibrosing-alopecia-treated-with-dutasteride-minoxidil-and-artificial-hair-transplantation
#7
William C Cranwell, Rodney Sinclair
A 46-year-old premenopausal woman presented with familial frontal fibrosis alopecia affecting the temples bilaterally. The diagnosis was confirmed histologically. Her past history included rheumatoid arthritis treated with hydroxychloroquine 400 mg daily and methotrexate 20 mg weekly. Serial intralesional injections of triamcinolone did not limit the progression of hair loss. Treatment with dutasteride 0.1 mg daily and minoxidil 1 mg daily stabilised hair loss and artificial fibre hair transplantation initially led to a satisfactory cosmetic outcome...
June 7, 2016: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/27225981/interventions-for-female-pattern-hair-loss
#8
REVIEW
Esther J van Zuuren, Zbys Fedorowicz, Jan Schoones
BACKGROUND: Female pattern hair loss (FPHL), or androgenic alopecia, is the most common type of hair loss affecting women. It is characterised by progressive shortening of the duration of the growth phase of the hair with successive hair cycles, and progressive follicular miniaturisation with conversion of terminal to vellus hair follicles (terminal hairs are thicker and longer, while vellus hairs are soft, fine, and short). The frontal hair line may or may not be preserved. Hair loss can have a serious psychological impact on women...
May 26, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27050696/side-effects-related-to-5-%C3%AE-reductase-inhibitor-treatment-of-hair-loss-in-women-a-review
#9
Lauren R Seale, Ariana N Eglini, Amy J McMichael
5 α-reductase inhibitors such as finasteride and dutasteride have been studied for the treatment of hair loss in men, with finasteride being the only Food and Drug Administration-approved treatment. Increasingly, in recent years, off-label use of these drugs has been employed in the treatment of female pattern hair loss (FPHL) and frontal fibrosing alopecia (FFA) in women. Side effects with 5 α-reductase inhibitors can include changes in sexual function, and recent publications have characterized an increasing prevalence of these in men...
April 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/26893187/long-term-safety-and-efficacy-of-dutasteride-in-the-treatment-of-male-patients-with-androgenetic-alopecia
#10
Yuichiro Tsunemi, Ryokichi Irisawa, Hiromu Yoshiie, Betsy Brotherton, Hisahiro Ito, Ryoji Tsuboi, Makoto Kawashima, Michael Manyak
Androgenetic alopecia is an androgen-induced pattern of progressive hair loss, which occurs in genetically predisposed people. This study aimed to determine long-term safety, tolerability and efficacy of dutasteride 0.5 mg, an inhibitor of 5-α-reductase, in Japanese male patients with androgenetic alopecia. This was a multicenter, open-label, prospective outpatient study (clinicaltrials.gov NCT01831791, GSK identifier ARI114264) in which patients took dutasteride 0.5 mg p.o. once daily for 52 weeks. Primary end-points included adverse event assessment, incidence of drug-related adverse event and premature discontinuations...
September 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/26296373/adverse-effects-of-5%C3%AE-reductase-inhibitors-what-do-we-know-don-t-know-and-need-to-know
#11
REVIEW
Abdulmaged M Traish, Roberto Cosimo Melcangi, Marco Bortolato, Luis M Garcia-Segura, Michael Zitzmann
Steroids are important physiological orchestrators of endocrine as well as peripheral and central nervous system functions. One of the key processes for regulation of these molecules lies in their enzymatic processing by a family of 5α-reductase (5α-Rs) isozymes. By catalyzing a key rate-limiting step in steroidogenesis, this family of enzymes exerts a crucial role not only in the physiological control but also in pathological events. Indeed, both 5α-R inhibition and supplementation of 5α-reduced metabolites are currently used or have been proposed as therapeutic strategies for a wide array of pathological conditions...
September 2015: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/26180450/nail-involvement-in-frontal-fibrosing-alopecia
#12
Melanie Macpherson, Parinaz Hohendorf-Ansari, Ralph Michel Trüeb
A case of frontal fibrosing alopecia with nail involvement is presented. Nail involvement provides evidence for underlying lichen planus, and that the disease represents a rather generalized than localized process. Favorable response of the scalp condition to oral dutasteride points to an inflammatory reaction on the background of androgenetic alopecia.
April 2015: International Journal of Trichology
https://www.readbyqxmd.com/read/25382509/the-effectiveness-of-finasteride-and-dutasteride-used-for-3-years-in-women-with-androgenetic-alopecia
#13
Ids H Boersma, Arnold P Oranje, Ramon Grimalt, Matilde Iorizzo, Bianca M Piraccini, Emiel H Verdonschot
BACKGROUND: The effectiveness of finasteride and dutasteride in women with androgenetic alopecia has been the subject of debate. AIM: To evaluate the effectiveness of finasteride and dutasteride on hair loss in women with androgenetic alopecia over a period of 3 years. METHODS: From a database containing systematically retrieved data on 3500 women treated for androgenetic alopecia between 2002 and 2012 with finasteride 1.25 mg or dutasteride 0...
November 2014: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/25268732/5%C3%AE-reductase-inhibitors-in-androgenetic-alopecia
#14
REVIEW
Elizabeth Yim, Katherine L Baquerizo Nole, Antonella Tosti
PURPOSE OF REVIEW: The authors will review the current literature on efficacy and safety of 5-alpha reductase inhibitors (5αRIs) for androgenetic alopecia (AGA). RECENT FINDINGS: The 5αRI finasteride and dutasteride are effective in treating AGA and promoting hair regrowth. 5αRI can be given orally, topically and more recently through mesotherapy. However, there has been an increasing concern about permanent sexual adverse events such as impotence and infertility...
December 2014: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/25085659/enhanced-skin-permeation-of-5%C3%AE-reductase-inhibitors-entrapped-into-surface-modified-liquid-crystalline-nanoparticles
#15
Thiagarajan Madheswaran, Rengarajan Baskaran, Pasupathi Sundaramoorthy, Bong Kyu Yoo
The objective of this study is to enhance skin permeation of finasteride and dutasteride for the treatment of androgenetic alopecia using surface-modified liquid crystalline nanoparticle (sm-LCN) dispersion. LCN entrapped with the drugs was prepared by using monoolein as a liquid crystal former, and surface modification was performed by treatment of the LCN dispersion with same volume of 1 % v/v acetic acid solution containing chitosan. Physicochemical properties of the LCN's were studied with regard to particle size, polydispersity index, zeta potential, and release of the drugs...
April 2015: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/24898559/effect-of-dutasteride-0-5%C3%A2-mg-d-in-men-with-androgenetic-alopecia-recalcitrant-to-finasteride
#16
Jae Yoon Jung, Je Ho Yeon, Jee Woong Choi, Soon Hyo Kwon, Beom Joon Kim, Sang Woong Youn, Kyoung Chan Park, Chang Hun Huh
BACKGROUND: Finasteride at a dose of 1 mg/d has been reported to show no significant improvement in 30-50% of patients with androgenetic alopecia (AGA). Dutasteride, a dual inhibitor of both type I and type II 5 alpha-reductase, inhibits the conversion of testosterone to dihydrotestosterone, which is the key contributor of AGA. MATERIALS AND METHODS: Our aim is to evaluate clinical efficacy and tolerability of dutasteride in men with AGA who do not show clinical improvement to the conventional finasteride treatment...
November 2014: International Journal of Dermatology
https://www.readbyqxmd.com/read/24508293/frontal-fibrosing-alopecia-a-multicenter-review-of-355-patients
#17
MULTICENTER STUDY
Sergio Vañó-Galván, Ana M Molina-Ruiz, Cristina Serrano-Falcón, Salvador Arias-Santiago, Ana R Rodrigues-Barata, Gloria Garnacho-Saucedo, Antonio Martorell-Calatayud, Pablo Fernández-Crehuet, Ramón Grimalt, Beatriz Aranegui, Emiliano Grillo, Blanca Diaz-Ley, Rafael Salido, Sivia Pérez-Gala, Salvio Serrano, Jose Carlos Moreno, Pedro Jaén, Francisco M Camacho
BACKGROUND: To our knowledge, there are no large multicenter studies concerning frontal fibrosing alopecia (FFA) that could give clues about its pathogenesis and best treatment. OBJECTIVE: We sought to describe the epidemiology, comorbidities, clinical presentation, diagnostic findings, and therapeutic choices in a large series of patients with FFA. METHODS: This retrospective multicenter study included patients given the diagnosis of FFA...
April 2014: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/24411083/a-randomized-active-and-placebo-controlled-study-of-the-efficacy-and-safety-of-different-doses-of-dutasteride-versus-placebo-and-finasteride-in-the-treatment-of-male-subjects-with-androgenetic-alopecia
#18
RANDOMIZED CONTROLLED TRIAL
Walter Gubelin Harcha, Julia Barboza Martínez, Tsen-Fang Tsai, Kensei Katsuoka, Makoto Kawashima, Ryoji Tsuboi, Allison Barnes, Geraldine Ferron-Brady, Dushen Chetty
BACKGROUND: Dihydrotestosterone is the main androgen causative of androgenetic alopecia, a psychologically and physically harmful condition warranting medical treatment. OBJECTIVE: We sought to compare the efficacy and safety of dutasteride (type 1 and 2 5-alpha reductase inhibitor) with finasteride (type 2 5-alpha reductase inhibitor) and placebo in men with androgenetic alopecia. METHODS: Men aged 20 to 50 years with androgenetic alopecia were randomized to receive dutasteride (0...
March 2014: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/24348386/hyperpigmentation-following-treatment-of-frontal-fibrosing-alopecia
#19
Irma Margarita Pérez-Rodríguez, Martha Elena García-Melendez, Kristian Eichelmann, Osvaldo Vázquez-Martínez, Jorge Ocampo-Candiani
INTRODUCTION: Frontal fibrosing alopecia (FFA) is a scarring alopecia characterized by progressive recession of the frontotemporal hairline. Current treatment is aimed at stopping progression, and the combination of dutasteride and pimecrolimus is the most effective therapy. Side effects associated with dutasteride are erectile dysfunction as well as breast tenderness and enlargement, while pimecrolimus produces a burning sensation. CASE REPORT: We present a 57-year-old postmenopausal female with a 3-year history of a scarring alopecic plaque in her frontotemporal region...
2013: Case Reports in Dermatology
https://www.readbyqxmd.com/read/24039457/female-pattern-alopecia-current-perspectives
#20
REVIEW
Lauren L Levy, Jason J Emer
Hair loss is a commonly encountered problem in clinical practice, with men presenting with a distinctive pattern involving hairline recession and vertex balding (Norwood-Hamilton classification) and women exhibiting diffuse hair thinning over the crown (increased part width) and sparing of the frontal hairline (Ludwig classification). Female pattern hair loss has a strikingly overwhelming psychological effect; thus, successful treatments are necessary. Difficulty lies in successful treatment interventions, as only two medications - minoxidil and finasteride - are approved for the treatment of androgenetic alopecia, and these medications offer mediocre results, lack of a permanent cure, and potential complications...
August 29, 2013: International Journal of Women's Health
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