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polymyxin b hemoperfusion

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https://www.readbyqxmd.com/read/29340720/correction-to-polymyxin-b-immobilized-hemoperfusion-and-mortality-in-critically-ill-adult-patients-with-sepsis-septic-shock-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#1
Tomoko Fujii, Riki Ganeko, Yuki Kataoka, Toshi A Furukawa, Robin Featherstone, Kent Doi, Jean-Louis Vincent, Daniela Pasero, René Robert, Claudio Ronco, Sean M Bagshaw
Owing to an oversight by the authors, Figure 2 in this article was not the version intended for publication. The correct Figure 2, reproduced here, features footnote symbols and Figure 2b includes three studies as described in the main text.
January 16, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29221222/polymyxin-b-hemoperfusion-in-septic-shock-nothing-overmuch-meden-agan
#2
EDITORIAL
Stavroula Ilia, Panagiotis Briassoulis, George Briassoulis
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29204670/polymyxin-b-immobilized-hemoperfusion-and-mortality-in-critically-ill-adult-patients-with-sepsis-septic-shock-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis
#3
REVIEW
Tomoko Fujii, Riki Ganeko, Yuki Kataoka, Toshi A Furukawa, Robin Featherstone, Kent Doi, Jean-Louis Vincent, Daniela Pasero, René Robert, Claudio Ronco, Sean M Bagshaw
PURPOSE: Polymyxin B-immobilized hemoperfusion (PMX-HP) is an adjuvant therapy for sepsis or septic shock that clears circulating endotoxin. Prior trials have shown that PMX-HP improves surrogate endpoints. We aimed to conduct an evidence synthesis to evaluate the efficacy and safety of PMX-HP in critically ill adult patients with sepsis or septic shock. METHODS: We searched for randomized controlled trials (RCTs) in MEDLINE, EMBASE, the Cochrane Library, the Health Technology Assessment Database, CINAHL, "Igaku Chuo Zasshi", the National Institute of Health Clinical Trials Register, the World Health Organization International Clinical Trials Registry Platform, the University Hospital Medical Information Network Clinical Trials Registry, the reference lists of retrieved articles, and publications by manufacturers of PMX-HP...
December 4, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/29123880/efficacy-of-direct-hemoperfusion-with-a-polymyxin-b-immobilized-fiber-column-in-miliary-tuberculosis
#4
Yasumasa Kawano, Ryotaro Nagashima, Shinichi Morimoto, Yoshito Izutani, Reiko Yamasaki, Takeshi Nishida, Mitsutoshi Iwaasa, Hiroyasu Ishikura
Case: A 75-year-old woman presented with a 10-day history of intermittent fever, general fatigue, and progressive dyspnea. Although she had a low PaO2/FIO2 ratio, the cause of acute respiratory distress syndrome was not clear until day 9 in hospital. Outcome: We treated the patient with direct hemoperfusion with a polymyxin B-immobilized fiber column incidentally; the PaO2/FIO2 ratio improved following this therapy. Acid-fast bacilli, which were not seen in the sputum on admission, were detected in cultures from sputum, urine, bone marrow, liver biopsy, and blood samples, with a real-time polymerase chain reaction assay confirming tuberculosis...
July 2017: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29093381/the-serum-ferritin-level-is-associated-with-the-treatment-responsivity-for-rapidly-progressive-interstitial-lung-disease-with-amyopathic-dermatomyositis-irrespective-of-the-anti-mda5-antibody-level-a-case-report
#5
Takeshi Osawa, Kozo Morimoto, Yuka Sasaki, Shuichi Matsuda, Kazunari Yamana, Ryozo Yano, Takashi Uchiyama, Hajime Goto
We herein report he case of a 61-year-old woman with rapidly progressive interstitial lung disease caused by clinically amyopathic dermatomyositis. Both the serum ferritin and anti-MDA5 antibody levels were elevated at the time of admission. Despite intensive treatment with corticosteroids, immunosuppressants, immunoglobulins and polymyxin B direct hemoperfusion, the patient died 75 days after symptom onset. Over the course of treatment, the anti-MDA5 antibody level continually decreased, while the serum ferritin level increased, suggesting that sequential measurements of the serum ferritin level might be useful for evaluating the treatment responsivity, irrespective of the anti-MDA5 antibody level...
November 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29065861/clinical-effects-of-direct-hemoperfusion-using-a-polymyxin-b-immobilized-fiber-column-in-clinically-amyopathic-dermatomyositis-associated-rapidly-progressive-interstitial-pneumonias
#6
Hiroko Okabayashi, Hidenori Ichiyasu, Sayuri Hirooka, Kimitaka Akaike, Keisuke Kojima, Takayuki Jodai, Yasumiko Sakamoto, Hideharu Ideguchi, Shohei Hamada, Chieko Yoshida, Susumu Hirosako, Shinichiro Okamoto, Hirotsugu Kohrogi
BACKGROUND: Rapidly progressive interstitial pneumonias (RPIPs) associated with clinically amyopathic dermatomyositis (CADM) are highly resistant to therapy and have a poor prognosis. Multimodal therapies, including direct hemoperfusion using a polymyxin B-immobilized fiber column (PMX-DHP), have a protective effect on RPIPs. We evaluated the effects of PMX-DHP on CADM-associated RPIPs. METHODS: We retrospectively enrolled 14 patients with CADM-associated RPIPs and acute respiratory failure treated with PMX-DHP, corticosteroids, and immunosuppressive agents...
October 24, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28991050/selective-lps-adsorption-using-polymyxin-b-immobilized-fiber-cartridges-in-sepsis-patients-following-cardiac-surgery
#7
Michael Yaroustovsky, Marina Abramyan, Ekaterina Komardina, Helen Nazarova, Dmitrii Popov, Marina Plyushch, Alina Soldatkina, Ekaterina Rogalskaya
Sepsis remains the leading cause of morbidity and mortality in intensive care units. The extracorporeal therapy in the complex treatment of sepsis seems to be the most promising direction.The aim of this study was to assess the safety and effectiveness of selective endotoxin adsorption on the basis of the analysis of our own experience with the intensive therapy for sepsis in adult cardiac surgical patients. MATERIALS AND METHODS: Our single-center study included 143 patients with sepsis...
October 4, 2017: Shock
https://www.readbyqxmd.com/read/28942888/direct-hemoperfusion-with-polymyxin-b-immobilized-fiber-for-the-treatment-of-the-acute-exacerbation-of-idiopathic-pulmonary-fibrosis-in-patients-requiring-invasive-mechanical-ventilation
#8
Masamichi Komatsu, Tsutomu Hachiya, Hidekazu Takahashi, Sawako Yoshikawa, Takayuki Honda
The prognosis of acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) in individuals undergoing invasive mechanical ventilation is known to be poor. We describe the cases of three men, who were former smokers and required mechanical ventilation, whose AE-IPF was treated with direct hemoperfusion with polymyxin B-immobilized fiber column (PMX-DHP). In all cases, we successfully weaned the patients from mechanical ventilation. Two of the patients survived for more than 180 days after development of AE-IPF...
September 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28931287/enhanced-capture-of-bacteria-and-endotoxin-by-antimicrobial-wlbu2-peptide-tethered-on-polyethylene-oxide-spacers
#9
Ramya Raman, Miranda A Raper, Erik Hahn, Kate F Schilke
Severe sepsis is a life threatening immune response that may be caused by endotoxins (lipopolysaccharides) in circulating bacterial cell wall fragments. Hemoperfusion through a sorbent column coated with the antimicrobial peptide polymyxin B (PMB) is a promising treatment for sepsis. However, PMB is cytotoxic and neurotoxic, and is a membrane disruptor that may fragment endotoxin vesicles. In addition, the blood is not protected from nonspecific interactions with the synthetic surface of the solid support. These effects may be responsible for the variety of undesirable clinical outcomes, including nonspecific adsorption of proteins, blood cell damage, platelet activation, and a lack of clear evidence of efficacy of the current hemoperfusion products...
September 20, 2017: Biointerphases
https://www.readbyqxmd.com/read/28923774/endotoxin-adsorption-direct-hemoperfusion-with-the-polymyxin-b-immobilized-fiber-column-pmx
#10
REVIEW
Tomoharu Shimizu, Toru Miyake, Naomi Kitamura, Masaji Tani, Yoshihiro Endo
Toraymyxin(®) is a medical device developed to adsorb circulating endotoxins in the blood using direct hemoperfusion therapy for patients with septic shock. In 1994, the Japanese National Health Insurance system approved the use of Toraymyxin for the treatment of endotoxemia and septic shock. Since then, Toraymyxin has been safely used in more than 100,000 cases in emergency and intensive care units in Japan. Toraymyxin is currently available for use in the clinical setting in 14 countries worldwide. In this study, we reviewed and introduced the development, clinical use, and efficacy of Toraymyxin and commented on its anticoagulant use and cartridge clotting issue in the treatment of severe sepsis and septic shock...
August 31, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28915395/effects-of-polymyxin-b-hemoperfusion-on-hemodynamics-and-prognosis-in-septic-shock-patients
#11
Chen-Tse Lee, Yu-Kang Tu, Yi-Chun Yeh, Tzu Chang, Po-Yuan Shih, Anne Chao, Hsing-Hao Huang, Ya-Jung Cheng, Yu-Chang Yeh
PURPOSE: We designed this study to examine the clinical effects of polymyxin B hemoperfusion (PMX-HP) in septic shock patients. MATERIAL AND METHODS: We retrospectively examined the effects of PMX-HP in septic shock patients with intra-abdominal or gram-negative bacterial infection during October 2013-May 2016. A one-to-one matching between the PMX-HP and conventional groups was performed, and 28-day mortality, and change in inotropic score, Sequential Organ Failure Assessment (SOFA) score, and Acute Physiology and Chronic Health Evaluation II (APACHE II) score at 24h in the two groups were compared...
April 25, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28690852/is-polymyxin-b-immobilized-fiber-column-ineffective-for-septic-shock-a-discussion-on-the-press-release-for-euphrates-trial
#12
Toshiaki Iba, Lucy Fowler
The efficacy of polymyxin B-immobilized (PMX) fiber column on septic shock is still under debate. Recently, the result from "Evaluating the Use of Polymyxin B Hemoperfusion in a Randomized controlled trial of Adults Treated for Endotoxemia and Septic shock (EUPHRATES)" trial has been announced as a press release. According to that report, less than a 5% mortality difference was recognized in the "per protocol population" (n = 244, 31.9 vs. 36.9%) and the decrease was not statistically significant. However, among the patients in refractory shock with a multiple organ dysfunction score of more than 9 and an EAA between 0...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28601867/novel-insights-into-the-direct-removal-of-endotoxin-by-polymyxin-b-hemoperfusion
#13
Alexander D Romaschin, Christina V Obiezu-Forster, Hisataka Shoji, David J Klein
AIM: To demonstrate the capacity of polymyxin B-direct hemoperfusion (PMX-DHP) column Toraymyxin® 20R (PMX-20R) in removing endotoxin (LPS) from perfused blood, serum and plasma. METHODS: Endotoxin-spiked bovine serum or plasma was perfused in PMX-20R as per the recommended performance testing protocol. Samples were taken at various time points to assess the amount of endotoxin removed during a 4-h session. In another set of experiments, FITC-labelled LPS (FITC-LPS) was spiked into a pool of human whole blood, followed by perfusion with the spiked blood for 2 h in order to allow FITC-LPS to bind PMX-20R...
2017: Blood Purification
https://www.readbyqxmd.com/read/28600615/clinical-study-of-blood-purification-therapy-in-critical-care-in-japan-results-from-the-survey-research-of-the-japan-society-for-blood-purification-in-critical-care-in-2013
#14
Toshiaki Arimura, Masanori Abe, Hidetoshi Shiga, Hiroshi Katayama, Kazo Kaizu, Shigeto Oda
To clarify the clinical status of blood purification therapy (BPT) in critical care in Japan, we conducted a cohort study using data from a nationwide registry of the Japan Society for Blood Purification in Critical Care in 2013. We enrolled 2227 patients treated with BPT (female, 39.1%; mean age, 65.5 ± 12.1 years) in the intensive care units of 43 facilities. Patient characteristics, modes of BPT, and survival rate for each disease were investigated. In total, BPT was performed 3053 times. Continuous renal replacement therapy (CRRT) (57...
June 9, 2017: Journal of Artificial Organs: the Official Journal of the Japanese Society for Artificial Organs
https://www.readbyqxmd.com/read/28597511/successful-treatment-of-enterohemorrhagic-escherichia-coli-induced-acute-encephalopathy-and-hemolytic-uremic-syndrome-with-polymyxin-b-direct-hemoperfusion
#15
LETTER
Hisashi Kaneda, Masaki Shimizu, Akihiro Yachie
No abstract text is available yet for this article.
August 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28592318/potential-survival-benefit-of-polymyxin-b-hemoperfusion-in-patients-with-septic-shock-a-propensity-matched-cohort-study
#16
Yoshihiko Nakamura, Taisuke Kitamura, Fumiaki Kiyomi, Mineji Hayakawa, Kota Hoshino, Yasumasa Kawano, Reiko Yamasaki, Takeshi Nishida, Mariko Mizunuma, Hiroyasu Ishikura
BACKGROUND: The purpose of this study was to investigate whether polymyxin B hemoperfusion (PMX-HP) improves the survival of patients with septic shock. METHODS: This was a retrospective, multicenter study conducted on patients treated during a 3-year period. We performed propensity-score analyses of the Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study database. The study included data on 1723 patients with septic shock aged 16 years or older...
June 7, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28589262/the-surgical-outcomes-of-lung-cancer-combined-with-interstitial-pneumonia-a-single-institution-report
#17
Daisuke Taniguchi, Naoya Yamasaki, Takuro Miyazaki, Tomoshi Tsuchiya, Keitaro Matsumoto, Go Hatachi, Tomoyuki Kakugawa, Noriho Sakamoto, Hiroshi Mukae, Takeshi Nagayasu
PURPOSE: Several studies have reported that an acute exacerbation (AE) of idiopathic interstitial pneumonia (IIP) can occur after lung resection in patients with non-small cell lung cancer (NSCLC); however, the perioperative management strategy is controversial. METHODS: The data of lung cancer patients at Nagasaki University Hospital from June 1994 to October 2013 were retrospectively reviewed. RESULTS: Among all 1701 NSCLC patients who underwent lung resection, 59 (3...
June 6, 2017: Surgery Today
https://www.readbyqxmd.com/read/28554260/efficacy-of-direct-hemoperfusion-using-polymyxin-b-immobilized-fiber-column-pmx-dhp-in-rapidly-progressive-interstitial-pneumonias-results-of-a-historical-control-study-and-a-review-of-previous-studies
#18
Hidenori Ichiyasu, Yuko Horio, Aiko Masunaga, Yohei Migiyama, Yasumiko Sakamoto, Takayuki Jodai, Hideharu Ideguchi, Hiroko Okabayashi, Shohei Hamada, Chieko Yoshida, Susumu Hirosako, Shinichiro Okamoto, Hirotsugu Kohrogi
BACKGROUND: Direct hemoperfusion using polymyxin B-immobilized fiber column (PMX-DHP) therapy has been approved for sepsis-associated acute respiratory distress syndrome, but its efficacy for other rapidly progressive interstitial pneumonias (RPIPs) is unclear. The purpose of this study was to examine the efficacy of PMX-DHP therapy for acute respiratory failure in patients with RPIPs, when compared with a historical control receiving conventional treatment without PMX-DHP. METHODS: This study comprised 77 patients with RPIPs in our institute between January 2002 and December 2015...
July 2017: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/28543432/clinically-amyopathic-dermatomyositis-with-rapidly-progressive-interstitial-pneumonia-the-relation-between-the-disease-activity-and-the-serum-interleukin-6-level
#19
Hazuki Yasuda, Takaharu Ikeda, Yasuhito Hamaguchi, Fukumi Furukawa
A 67-year-old woman exhibited chilblain-like erythema on the bilateral auricles, erythema with hyperkeratosis on the sides of fingers and the bilateral elbows, and erythema on the extensor/flexor sides of the finger joints and the iliac regions. Fine crackles were audible on the dorsal side of the bilateral lower lung regions. We diagnosed clinically amyopathic dermatomyositis accompanied by rapidly progressive interstitial pneumonia. While we initiated immunosuppressive therapy, the respiratory failure showed no responses...
October 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28501124/effects-of-endotoxin-absorber-hemoperfusion-on-microcirculation-in-septic-pigs
#20
Yu-Chang Yeh, Linda Chia-Hui Yu, Chun-Yu Wu, Ya-Jung Cheng, Chen-Tse Lee, Wei-Zen Sun, Jui-Chang Tsai, Tzu-Yu Lin
BACKGROUND: Endotoxins contribute to systemic inflammatory response and microcirculatory dysfunctions under conditions of sepsis. Polymyxin B hemoperfusion (PMX-HP) is used to remove circulating endotoxins and improve clinical outcomes. This study aims to investigate the effect of PMX-HP on microcirculation in septic pigs. MATERIALS AND METHODS: By using a septic pig model, we tested the hypothesis that PMX-HP can correct intestinal microcirculation, tissue oxygenation saturation, and histopathologic alterations...
May 1, 2017: Journal of Surgical Research
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