Feng Xiao, Yaling Jia, Simeng Zhang, Nanfang Liu, Xuelong Zhang, Tianci Wang, Jialu Qiao, Ge Yang, Xu Che, Keli Chen, Pan Pan, Lingli Zhou, Binlian Sun, Jun Chen, Pin Wan
The NACHT, leucine-rich repeat, and pyrin domains-containing protein 3 (collectively known as NLRP3) inflammasome activation plays a critical role in innate immune and pathogenic microorganism infections. However, excessive activation of NLRP3 inflammasome will lead to cellular inflammation and tissue damage, and naturally it must be precisely controlled in the host. Here, we discovered that solute carrier family 25 member 3 (SLC25A3), a mitochondrial phosphate carrier protein, plays an important role in negatively regulating NLRP3 inflammasome activation...
March 27, 2024: Journal of Biological Chemistry