keyword
https://read.qxmd.com/read/38546584/nlrp3-inflammasome-priming-in-the-retina-of-diabetic-mice-requires-redd1-dependent-activation-of-gsk3%C3%AE
#1
JOURNAL ARTICLE
Christopher M McCurry, Siddharth Sunilkumar, Sandeep M Subrahmanian, Esma I Yerlikaya, Allyson L Toro, Ashley M VanCleave, Shaunaci A Stevens, Alistair J Barber, Jeffery M Sundstrom, Michael D Dennis
PURPOSE: Inflammasome activation has been implicated in the development of retinal complications caused by diabetes. This study was designed to identify signaling events that promote retinal NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation in response to diabetes. METHODS: Diabetes was induced in mice by streptozotocin administration. Retinas were examined after 16 weeks of diabetes. Human MIO-M1 Müller cells were exposed to hyperglycemic culture conditions...
March 5, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38543085/implications-of-nlrp3-suppression-using-glibenclamide-and-mir-223-against-colorectal-cancer
#2
JOURNAL ARTICLE
Shaimaa Hamza, Ekaterina E Garanina, Layaly Shkair, Mohammad Alsaadi, Svetlana F Khaiboullina, Gulcin Tezcan
The NLR family pyrin domain containing 3 (NLRP3) promotes the growth of colorectal cancer (CRC). However, the therapeutic effect of NLRP3 inhibition on CRC cell progression is controversial. This study comparatively investigated the therapeutic effect of a pharmacological NLRP3 inhibitor, glibenclamide (gli), and the post-translational suppression of NLRP3 by miR-223 on CRC cell progression in HCT-116 and HCT-15 cells. LPS and ATP were used to activate Gli-treated and LSB-hsa-miR-223-3p (WTmiR-223 )-expressing HCT-116 cells...
February 26, 2024: Pharmaceuticals
https://read.qxmd.com/read/38543036/vitamin-d-mitigates-hepatic-fat-accumulation-and-inflammation-and-increases-sirt1-ampk-expression-in-aml-12-hepatocytes
#3
JOURNAL ARTICLE
Eugene Chang
Emerging evidence has demonstrated a strong correlation between vitamin D status and fatty liver disease. Aberrant hepatic fat infiltration contributes to oxidant overproduction, promoting metabolic dysfunction, and inflammatory responses. Vitamin D supplementation might be a good strategy for reducing hepatic lipid accumulation and inflammation in non-alcoholic fatty liver disease and its associated diseases. This study aimed to investigate the role of the most biologically active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), in hepatic fat accumulation and inflammation in palmitic acid (PA)-treated AML-12 hepatocytes...
March 21, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38539253/liver-specific-adiponectin-gene-therapy-suppresses-microglial-nlrp3-inflammasome-activation-for-treating-alzheimer-s-disease
#4
JOURNAL ARTICLE
Roy Chun-Laam Ng, Min Jian, Oscar Ka-Fai Ma, Ariya Weiman Xiang, Myriam Bunting, Jason Shing-Cheong Kwan, Curtis Wai-Kin Wong, Leung-Wah Yick, Sookja Kim Chung, Karen Siu-Ling Lam, Ian E Alexander, Aimin Xu, Koon-Ho Chan
Adiponectin (APN) is an adipokine which predominantly expresses in adipocytes with neuroprotective and anti-inflammatory effects. We have recently indicated that circulatory trimeric APN can enter the brain by crossing the blood-brain barrier (BBB) and modulate microglia-mediated neuroinflammation. Here, we found that the microglial NLR family pyrin domain containing 3 (NLRP3)-inflammasome activation was exacerbated in APN-/- 5xFAD mice in age-dependent manner. The focus of this study was to develop a new and tractable therapeutic approach for treating Alzheimer's disease (AD)-related pathology in 5xFAD mice using peripheral APN gene therapy...
March 27, 2024: Journal of Neuroinflammation
https://read.qxmd.com/read/38532054/atp-releasing-channels-and-the-ameliorative-effects-of-high-intensity-interval-training-on-diabetic-heart-a-multifaceted-analysis
#5
JOURNAL ARTICLE
Siyavash Joukar, Mohammad Amin Rajizadeh, Mohammad Abbas Bejeshk, Samaneh Sadat Alavi, Fatemeh Bagheri, Mohammad Rami, Kayvan Khoramipour
Type 2 diabetes (T2D) can cause severe cardiac complications at functional, histologic and molecular levels. These pathological complications could be mediated by ATP-releasing channels such as Panx1 and ATP receptors, in particular P2X7. The aim of our study was to investigate the effect of high-intensity interval training (HIIT) on T2D-induced cardiac complications at the functional, histopathological and molecular levels, with a particular focus on ATP-releasing channels. 48 male Wistar rats at the age of 8 weeks were randomly allocated into four groups: control (Con), Diabetes (T2D), Training (TR), and Diabetes + Training (T2D + TR)...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38530519/therapeutic-effect-of-levetiracetam-against-thioacetamide-induced-hepatic-encephalopathy-through-inhibition-of-oxidative-stress-and-downregulation-of-nf-%C3%AE%C2%BAb-nlrp3-inos-no-pro-inflammatory-cytokines-and-apoptosis
#6
JOURNAL ARTICLE
Keyvan Amirshahrokhi, Mahsa Imani
Hepatic encephalopathy (HE) is a serious brain disorder which associated with neurological and psychiatric manifestations. Oxidative stress and neuroinflammation and apoptosis play main roles in the development of brain damage in HE. Levetiracetam is an antiseizure drug with established antioxidant and anti-inflammatory activities. In the present study we investigated the therapeutic effects of levetiracetam against brain injury in HE and its underlying mechanisms of action. Male C57BL/6 mice were subjected to the induction of HE by the injection of thioacetamide (200 mg/kg) for 2 days...
March 26, 2024: Inflammation
https://read.qxmd.com/read/38526276/nlrp3-1-mediated-pyroptosis-beneficial-clues-for-the-development-of-novel-therapies-for-alzheimer-s-disease
#7
JOURNAL ARTICLE
Bo Hu, Jiaping Zhang, Jie Huang, Bairu Luo, Xiansi Zeng, Jinjing Jia
The inflammasome is a multiprotein complex involved in innate immunity that mediates the inflammatory response leading to pyroptosis, which is a lytic, inflammatory form of cell death. There is accumulating evidence that nucleotide-binding domain and leucine-rich repeat pyrin domain containing 3 (NLRP3) inflammasome-mediated microglial pyroptosis and NLRP1 inflammasome-mediated neuronal pyroptosis in the brain are closely associated with the pathogenesis of Alzheimer's disease. In this review, we summarize the possible pathogenic mechanisms of Alzheimer's disease, focusing on neuroinflammation...
November 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38525136/pulmonary-toxicity-assessment-of-polypropylene-polystyrene-and-polyethylene-microplastic-fragments-in-mice
#8
JOURNAL ARTICLE
Isaac Kwabena Danso, Jong-Hwan Woo, Seung Hoon Baek, Kilsoo Kim, Kyuhong Lee
UNLABELLED: Polypropylene (PP), polystyrene (PS), and polyethylene (PE) plastics are commonly used in household items such as electronic housings, food packaging, bottles, bags, toys, and roofing membranes. The presence of inhalable microplastics in indoor air has become a topic of concern as many people spent extended periods of time indoors during the COVID-19 pandemic lockdown restrictions, however, the toxic effects on the respiratory system are not properly understood. We examined the toxicity of PP, PS, and PE microplastic fragments in the pulmonary system of C57BL/6 mice...
April 2024: Toxicological Research
https://read.qxmd.com/read/38521466/ddit3-chop-promotes-lps-atp-induced-pyroptosis-in-osteoblasts-via-mitophagy-inhibition
#9
JOURNAL ARTICLE
Zhipeng Dong, Beining Yang, Meie Jia, Chang Yang, Shuo Wang, Hailin Mu, Jiawei Wang
Inflammatory environments can trigger endoplasmic reticulum (ER) stress and lead to pyroptosis in various tissues and cells, including liver, brain, and immune cells. As a key factor of ER stress, DNA damage-inducible transcript 3 (DDIT3)/CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) is upregulated in osteoblasts during inflammatory stimulation. DDIT3/CHOP may therefore regulate osteoblast pyroptosis in inflammatory conditions. During this investigation, we found that lipopolysaccharides (LPS)/adenosine 5'-triphosphate (ATP) stimulation in vitro induced osteoblasts to undergo pyroptosis, and the expression of DDIT3/CHOP was increased during this process...
March 21, 2024: Biochimica et Biophysica Acta. Molecular Cell Research
https://read.qxmd.com/read/38521117/the-role-of-the-nlrp3-inflammasome-in-atherosclerotic-disease-systematic-review-and-meta-analysis
#10
REVIEW
Marina Khair, Mark Khair, Venkat N Vangaveti, Usman H Malabu
Atherosclerosis is a chronic, progressive cardiovascular disease characterized by cholesterol deposition within blood vessel walls. Recent literature has suggested that the NLRP3 [NOD (nucleotide oligomerization domain)-, LRR (leucine-rich repeat)-, and PYD (pyrin domain)-containing protein 3] inflammasome is a key mediator in the development, progression, and destabilization of atherosclerotic plaques. This review aims to evaluate the current literature on the role of NLRP3 in human atherosclerosis. This systematic review was registered on the PROSPERO database (ID = CRD42022340039) and involved the search of a total of 8 databases...
March 22, 2024: Journal of Cardiology
https://read.qxmd.com/read/38520688/a-stress-sensor-ire1%C3%AE-is-required-for-bacterial-exotoxin-induced-interleukin-1%C3%AE-production-in-tissue-resident-macrophages
#11
JOURNAL ARTICLE
Izumi Sasaki, Yuri Fukuda-Ohta, Chihiro Nakai, Naoko Wakaki-Nishiyama, Chizuyo Okamoto, Daisuke Okuzaki, Shuhei Morita, Shiori Kaji, Yuki Furuta, Hiroaki Hemmi, Takashi Kato, Asumi Yamamoto, Emi Tosuji, Shin-Ichiroh Saitoh, Takashi Tanaka, Katsuaki Hoshino, Shinji Fukuda, Kensuke Miyake, Etsushi Kuroda, Ken J Ishii, Takao Iwawaki, Koichi Furukawa, Tsuneyasu Kaisho
Cholera toxin (CT), a bacterial exotoxin composed of one A subunit (CTA) and five B subunits (CTB), functions as an immune adjuvant. CTB can induce production of interleukin-1β (IL-1β), a proinflammatory cytokine, in synergy with a lipopolysaccharide (LPS), from resident peritoneal macrophages (RPMs) through the pyrin and NLRP3 inflammasomes. However, how CTB or CT activates these inflammasomes in the macrophages has been unclear. Here, we clarify the roles of inositol-requiring enzyme 1 alpha (IRE1α), an endoplasmic reticulum (ER) stress sensor, in CT-induced IL-1β production in RPMs...
March 22, 2024: Cell Reports
https://read.qxmd.com/read/38518686/helicobacter-pylori-secretary-proteins-induced-oxidative-stress-and-its-role-in-nlrp3-inflammasome-activation
#12
JOURNAL ARTICLE
Sandeep Kumar, Monisha Dhiman
Helicobacter pylori-associated stomach infection is a leading cause of gastric ulcer and related cancer. H. pylori modulates the functions of infiltrated immune cells to survive the killing by reactive oxygen and nitrogen species (ROS and RNS) produced by these cells. Uncontrolled immune responses further produce excess ROS and RNS which lead to mucosal damage. The persistent oxidative stress is a major cause of gastric cancer. H. pylori regulates nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs), nitric oxide synthase 2 (NOS2), and polyamines to control ROS and RNS release through lesser-known mechanisms...
February 3, 2024: Cellular Immunology
https://read.qxmd.com/read/38517616/resveratrol-ameliorates-retinal-ischemia-reperfusion-injury-by-modulating-the-nlrp3-inflammasome-and-keap1-nrf2-ho-1-signaling-pathway
#13
JOURNAL ARTICLE
Jiazhen Feng, Kaibao Ji, Yiji Pan, Pingping Huang, Tao He, Yiqiao Xing
Glaucoma, as an ischemia-reperfusion (I/R) injury disease, leading irreversible blindness through the loss of retinal ganglion cells (RGCs), mediated by various pathways. Resveratrol (Res) is a polyphenolic compound that exerts protective effects against I/R injury in many tissues. This article aimed to expound the underlying mechanisms through which Res protects RGCs and reduces visual dysfunction in vivo. An experimental glaucoma model was created using 6-8-week wild-type male C57BL/6J mice. Res was injected intraperitoneally for 5 days...
March 22, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38509896/combined-analysis-of-bulk-rna-and-single-cell-rna-sequencing-to-identify-pyroptosis-related-markers-and-the-role-of-dendritic-cells-in-chronic-obstructive-pulmonary-disease
#14
JOURNAL ARTICLE
Huiyan Zheng, Guifeng Wang, Yunlai Wang, Qixian Wang, Ting Sun
Chronic obstructive pulmonary disease (COPD) is characterized by dyspnea caused by airflow limitation. Further development may lead to decreased lung function and other lung diseases. Pyroptosis is a type of programmed cell death that involves multiple pathways. For example, the pathway induced by the NLR family pyrin domain containing 3 (NLRP3) inflammasome is closely associated with COPD exacerbation. Therefore, in this study, various machine learning algorithms were applied to screen for diagnostically relevant pyroptosis-related genes from the GEO dataset, and the results were verified using external datasets...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38508095/fibroblast-growth-factor-21-mitigates-lupus-nephritis-progression-via-the-fgf21-irgm-1-nlrp3-inflammasome-pathway
#15
JOURNAL ARTICLE
Yimeng Zou, Dan Wang, Wenying Sun, Qing Wu, Shijie Liu, Zeheng Ren, Yanan Li, Tianqi Zhao, Zhitong Li, Xinyu Li, Weiyue Cao, Jiachi Han, Xiaochen Guo, Guiping Ren
As an endocrine cytokine, fibroblast growth factor 21 (FGF21) exhibits anti-inflammatory properties. With the development of lupus nephritis (LN), which is tightly related to pathogenic factors, including inflammation and immune cell dysregulation, we explored the impact of Fibroblast Growth Factor 21 (FGF21) as well as its underlying mechanism. We induced an in vivo LN model using pristane in both wild-type C57BL/6 and FGF21 knockout (FGF21-/- ) mice. LN serum obtained from 32-week-old wild-type LN mice was used to stimulate RAW264...
March 19, 2024: International Immunopharmacology
https://read.qxmd.com/read/38504536/yemazhui-ameliorates-lipopolysaccharide-induced-acute-lung-injury-modulation-of-the-toll-like-receptor-4-nuclear-factor-kappa-b-nod-like-receptor-family-pyrin-domain-containing-3-protein-signaling-pathway-and-intestinal-flora-in-rats
#16
JOURNAL ARTICLE
Ren Li, Hai Yang, Yang Xue, Luo Xianqin
OBJECTIVE: To investigate the impact of Yemazhui ( Herba Eupatorii Lindleyani , HEL) against lipopolysaccharide (LPS)-induced acute lung injury (ALI) and explore its underlying mechanism in vivo . METHODS: The chemical constituents of HEL were analyzed by ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry method. Then, HEL was found to suppress LPS-induced ALI in vivo . Six-week-old male Sprague-Dawley rats were randomly divided into 6 groups: control, LPS, Dexamethasone (Dex), HEL low dose 6 g/kg (HEL-L), HEL medium dose 18 g/kg (HEL-M) and HEL high dose 54 g/kg (HEL-H) groups...
April 2024: Journal of Traditional Chinese Medicine
https://read.qxmd.com/read/38503169/dt-13-attenuates-inflammation-by-inhibiting-nlrp3-inflammasome-related-genes-in-raw264-7-macrophages
#17
JOURNAL ARTICLE
Shikha Raina, Emely Hübner, Esther Samuel, Gregor Nagel, Hendrik Fuchs
Plant derived saponins or other glycosides are widely used for their anti-inflammatory, antioxidant, and anti-viral properties in therapeutic medicine. In this study, we focus on understanding the function of the less known steroidal saponin from the roots of Liriope muscari L. H. Bailey - saponin C (also known as DT-13) in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages in comparison to the well-known saponin ginsenoside Rk1 and anti-inflammatory drug dexamethasone. We proved that DT-13 reduces LPS-induced inflammation by inhibiting nitric oxide (NO) production, interleukin-6 (IL-6) release, cycloxygenase-2 (COX-2), tumour necrosis factor-alpha (TNF-α) gene expression, and nuclear factor kappa-B (NFκB) translocation into the nucleus...
March 13, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38501503/fortunellin-ameliorates-lps-induced-acute-lung-injury-inflammation-and-collagen-deposition-by-restraining-the-tlr4-nf-%C3%AE%C2%BAb-nlrp3-pathway
#18
JOURNAL ARTICLE
Danjuan Liu, Rongjie Guo, Bingbing Shi, Min Chen, Shuoyun Weng, Junting Weng
OBJECTIVE: Acute lung injury (ALI) is the prevalent respiratory disease of acute inflammation with high morbidity and mortality. Fortunellin has anti-inflammation property, but its role in ALI remains elusive. Thus, this study clarified the function of fortunellin on ALI pathogenesis. METHODS: The ALI mouse model was established by lipopolysaccharide (LPS) induction, and lung tissue damage was evaluated utilizing hematoxylin-eosin (HE) staining. The edema of lung tissue was measured by the lung wet/dry (W/D) ratio...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38498304/design-and-synthesis-of-3-2-h-chromen-3-yl-5-aryl-1-2-4-oxadiazole-derivatives-as-novel-toll-like-receptor-2-1-agonists-that-inhibit-lung-cancer-in-vitro-and-in-vivo
#19
JOURNAL ARTICLE
Yijie Wang, Xu Cheng, Xinru Liu, Jing Xu, Lin Wang, Shouguo Zhang, Shuchen Liu, Tao Peng
Toll-like receptor (TLR) 2 is a transmembrane receptor that participates in the innate immune response by forming a heterodimer with TLR1 or TLR6. TLR2 agonists play an important role in tumor therapy. Herein, we synthesized a series of 3-(2 H -chromen-3-yl)-5-aryl-1,2,4-oxadiazole derivatives and identified WYJ-2 as a potent small and selective molecule agonist of TLR2/1, with an EC50 of 18.57 ± 0.98 nM in human TLR2 and TLR1 transient-cotransfected HEK 293T cells. WYJ-2 promoted the formation of TLR2/1 heterodimers and activated the nuclear factor kappa B (NF-κB) signaling pathway...
March 18, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38498283/understanding-propofol-s-protective-mechanism-in-tubular-epithelial-cells-mitigating-pyroptosis-via-the-mir-143-3p-atpase-na%C3%A2-%C3%A2-k%C3%A2-%C3%A2-transporting-subunit-alpha-2-pathway-in-renal-ischemia-reperfusion
#20
JOURNAL ARTICLE
Hongjun Kan, Miaomiao Zhao, Wei Wang, Baozhong Sun
Propofol (Pro), a prevalent intravenous anesthetic, has recently been recognized for its potential in mitigating ischemia-reperfusion (I/R) injuries. Despite a plethora of evidence suggesting the beneficial effects of low-dose Pro in renal I/R injury (RI/R), its role in modulating pyroptosis in renal tubular epithelial cells consequent to RI/R has not been thoroughly elucidated. In our investigation, we explored the therapeutic potential of Pro against pyroptosis in renal tubular epithelial cells under the duress of RI/R, employing both in vivo and in vitro models, while deciphering the intricate molecular pathways involved...
March 18, 2024: Molecular Biotechnology
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