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https://www.readbyqxmd.com/read/28332032/qualitative-assessment-of-the-symptoms-and-impact-of-pancreatic-exocrine-insufficiency-pei-to-inform-the-development-of-a-patient-reported-outcome-pro-instrument
#1
Colin D Johnson, Rob Arbuckle, Nicola Bonner, Gary Connett, Enrique Dominguez-Munoz, Philippe Levy, Doris Staab, Nicola Williamson, Markus M Lerch
BACKGROUND: Pancreatic exocrine insufficiency (PEI) affects patients with chronic pancreatitis (CP) and cystic fibrosis (CF) who produce insufficient digestive pancreatic enzymes. Common symptoms include steatorrhoea, diarrhea, and abdominal pain. OBJECTIVE: The objective of the study was to develop and test the content validity of a patient-reported outcome (PRO) instrument assessing PEI symptoms and their impact on health-related quality of life. METHODS: Instrument development was supported by a literature review, expert physician interviews (n = 10: Germany 4, UK 3, France 3), and exploratory, qualitative, concept-elicitation interviews with patients with CF and CP with PEI (n = 61: UK 29, Germany 18, France 14) and expert physicians (n = 10)...
March 22, 2017: Patient
https://www.readbyqxmd.com/read/28326010/impact-of-resveratrol-on-glucose-control-hippocampal-structure-and-connectivity-and-memory-performance-in-patients-with-mild-cognitive-impairment
#2
Theresa Köbe, A Veronica Witte, Ariane Schnelle, Valentina A Tesky, Johannes Pantel, Jan-Philipp Schuchardt, Andreas Hahn, Jens Bohlken, Ulrike Grittner, Agnes Flöel
In healthy older adults, resveratrol supplementation has been shown to improve long-term glucose control, resting-state functional connectivity (RSFC) of the hippocampus, and memory function. Here, we aimed to investigate if these beneficial effects extend to individuals at high-risk for dementia, i.e., patients with mild cognitive impairment (MCI). In a randomized, double-blind interventional study, 40 well-characterized patients with MCI (21 females; 50-80 years) completed 26 weeks of resveratrol (200 mg/d; n = 18) or placebo (1,015 mg/d olive oil; n = 22) intake...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28325712/enlight-a-comprehensive-quality-and-therapeutic-potential-evaluation-tool-for-mobile-and-web-based-ehealth-interventions
#3
Amit Baumel, Keren Faber, Nandita Mathur, John M Kane, Fred Muench
BACKGROUND: Studies of criteria-based assessment tools have demonstrated the feasibility of objectively evaluating eHealth interventions independent of empirical testing. However, current tools have not included some quality constructs associated with intervention outcome, such as persuasive design, behavior change, or therapeutic alliance. In addition, the generalizability of such tools has not been explicitly examined. OBJECTIVE: The aim is to introduce the development and further analysis of the Enlight suite of measures, developed to incorporate the aforementioned concepts and address generalizability aspects...
March 21, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28323592/measuring-uptake-and-elimination-of-nitrogen-in-humans-at-different-ambient-pressures
#4
Patrik Sundblad, Oskar Frånberg, Christoph Siebenmann, Mikael Gennser
BACKGROUND: To measure nitrogen (N2) wash-out and uptake requires elaborate set-ups, especially when doing the measurements at increased or decreased ambient pressure. Here we present a transportable device for quantifying N2 turnover in humans which can be used at different ambient pressures. METHODS: A modified close-circuit electronic rebreather was used to assess N2 turnover. Changes in N2 volume within the rebreathing circuit, reflecting N2 uptake or washout, were derived from the continuously monitored total system volume and the calculated volumes of oxygen and water vapor...
December 1, 2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28321787/a-mathematical-theory-of-shape-and-neuro-fuzzy-methodology-based-diagnostic-analysis-a-comparative-study-on-early-detection-and-treatment-planning-of-brain-cancer
#5
Subrata Kar, D Dutta Majumder
BACKGROUND: Investigation of brain cancer can detect the abnormal growth of tissue in the brain using computed tomography (CT) scans and magnetic resonance (MR) images of patients. The proposed method classifies brain cancer on shape-based feature extraction as either benign or malignant. The authors used input variables such as shape distance (SD) and shape similarity measure (SSM) in fuzzy tools, and used fuzzy rules to evaluate the risk status as an output variable. We presented a classifier neural network system (NNS), namely Levenberg-Marquardt (LM), which is a feed-forward back-propagation learning algorithm used to train the NN for the status of brain cancer, if any, and which achieved satisfactory performance with 100% accuracy...
March 20, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28319900/bipolar-electrochemiluminescence-on-thread-a-new-class-of-electroanalytical-sensors
#6
Rui Liu, Cuiling Liu, Huijie Li, Min Liu, Dan Wang, Chunsun Zhang
This paper introduces a new and simple concept for fabricating low-cost, easy-to-use capillary microchannel (CMC) assisted thread-based microfluidic analytical devices (CMCA-μTADs) for bipolar electrochemiluminescence (BP-ECL) application. The thread with patterns of carbon screen-printed electrodes and bare thread zones (BTZs) is embedded into a CMC. Such CMCA-μTADs can produce a strong and stable BP-ECL signal, and have an extremely low cost ($0.01 per device). Interestingly, the CMCA-μTADs are ultraflexible, and can be bent with a 135° bending angle at the BTZ or with a 150° bending angle at the middle of bipolar electrode (BPE), with no loss of analytical performance...
March 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28317114/personality-traits-as-patterns-of-meaning-assignment-tendencies
#7
Shulamith Kreitler
OBJECTIVE: The purpose is to present a new conception about the nature of personality traits based on the Kreitler Meaning System. The major constructs of the meaning system are referent, meaning value, meaning unit, and meaning variables characterizing the meaning unit. The individual's meaning profile is the set of meaning variables the individual uses as assessed by the Test of Meanings. Personality traits are defined as patterns of meaning assignment tendencies. METHOD: After introducing the meaning system the paper describes the new conception of personality traits, and presents the example of extroversion...
March 20, 2017: Journal of Personality
https://www.readbyqxmd.com/read/28315995/ligand-based-virtual-screening-under-partial-shape-constraints
#8
Mathias M von Behren, Matthias Rarey
Ligand-based virtual screening has proven to be a viable technology during the search for new lead structures in drug discovery. Despite the rapidly increasing number of published methods, meaningful shape matching as well as ligand and target flexibility still remain open challenges. In this work, we analyze the influence of knowledge-based sterical constraints on the performance of the recently published ligand-based virtual screening method mRAISE. We introduce the concept of partial shape matching enabling a more differentiated view on chemical structure...
March 18, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28302647/development-and-psychometric-properties-of-a-scale-to-measure-hospital-organizational-culture-for-cardiovascular-care
#9
Elizabeth H Bradley, Amanda L Brewster, Heather Fosburgh, Emily J Cherlin, Leslie A Curry
BACKGROUND: Because organizational culture is increasingly understood as fundamental to achieving high performance in hospital and other healthcare settings, the ability to measure this nuanced concept empirically has gained importance. Aside from measures of patient safety culture, no measure of organizational culture has been widely endorsed in the medical literature, limiting replication of previous findings and broader use in interventional studies. METHODS AND RESULTS: We sought to develop and assess the validity and reliability of a scale for assessing organizational culture in the context of hospitals' efforts to reducing 30-day risk-standardized mortality after acute myocardial infarction...
March 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28299476/a-comparison-of-the-molecular-subtypes-of-triple-negative-breast-cancer-among-non-asian-and-taiwanese-women
#10
Ling-Ming Tseng, Jen-Hwey Chiu, Chun-Yu Liu, Yi-Fang Tsai, Yun-Lin Wang, Chu-Wen Yang, Yi-Ming Shyr
BACKGROUND: "Precision medicine" is a concept that by utilizing modern molecular diagnostics, an effective therapy is accurately applied for each cancer patient to improve their survival rates. The treatment of triple-negative breast cancer (TNBC) remains a challenging issue. The aim of this study was to compare the molecular subtypes of triple-negative breast cancer (TNBC) between Taiwanese and Non-Asian women. METHODS: GEO Datasets for non-Asian (12 groups, n = 1450) and Taiwanese (3 groups, n = 465) breast cancer, including 617 TNBC, were acquired, normalized and cluster analyzed...
March 15, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28282990/validation-and-accuracy-of-intraoperative-ct-scan-using-the-philips-alluraxper-fd20-angiography-suite-for-assessment-of-spinal-instrumentation
#11
Edin Nevzati, Javier Fandino, Bawarjan Schatlo, Michel Heimberg, Serge Marbacher, Luca Remonda, Ali-Reza Fathi
BACKGROUND: With the concept of the hybrid operating room gaining popularity, the authors adapted a hybrid angiographic suite with intraoperative computed tomography (iCT) to evaluate accuracy of pedicle screw placement in spinal fusion. This retrospective review examines how well iCT detected extrapedicular screw violation, to then allow repositioning and potentially avoid revision surgery. METHODS: A total of 36 consecutive patients underwent pedicle screw placement in posterior cervical, thoracic, and lumbosacral spinal fusions...
March 10, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28278453/living-skin-classification-via-remote-ppg
#12
Wenjin Wang, Sander Stuijk, Gerard de Haan
Detecting living-skin tissue in a video on the basis of induced color changes due to blood pulsation is emerging for automatic region of interest localization in remote photoplethysmography (rPPG). However, the state-of-the-art method performing unsupervised living-skin detection in a video is rather time-consuming, which is mainly due to the high complexity of its unsupervised on-line learning for pulse/noise separation. In this paper, we address this issue by proposing a fast living-skin classification method...
March 1, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28274758/gfd-net-a-novel-semantic-similarity-methodology-for-the-analysis-of-gene-networks
#13
Juan J Díaz-Montaña, Norberto Díaz-Díaz, Francisco Gómez-Vela
Since the popularization of biological network inference methods, it has become crucial to create methods to validate the resulting models. Here we present GFD-Net, the first methodology that applies the concept of semantic similarity to gene network analysis. GFD-Net combines the concept of semantic similarity with the use of gene network topology to analyze the functional dissimilarity of gene networks based on Gene Ontology (GO). The main innovation of GFD-Net lies in the way that semantic similarity is used to analyze gene networks taking into account the network topology...
March 5, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28270443/skeletal-muscle-pgc-1%C3%AE-signaling-is-sufficient-to-drive-an-endurance-exercise-phenotype-and-to-counteract-components-of-detraining-in-mice
#14
Samuel Lee, Teresa C Leone, Lisa Rogosa, John Rumsey, Julio Ayala, Paul M Coen, Robert H Fitts, Rick B Vega, Daniel P Kelly
PPARgamma coactivator-1 (PGC-1) α; ;and β serve as master transcriptional regulators of muscle mitochondrial functional capacity and are capable of enhancing muscle endurance when overexpressed in mice. We sought to determine whether muscle-specific transgenic overexpression of PGC-1β affects the detraining response following endurance training. First, we established and validated a mouse exercise training/detraining protocol. Secondly, we found that overexpression of PGC-1β in skeletal muscle of sedentary mice fully recapitulated the training response using multiple physiological and gene expression endpoints...
March 7, 2017: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28265563/characteristics-and-validation-techniques-for-pca-based-gene-expression-signatures
#15
Anders E Berglund, Eric A Welsh, Steven A Eschrich
Background. Many gene-expression signatures exist for describing the biological state of profiled tumors. Principal Component Analysis (PCA) can be used to summarize a gene signature into a single score. Our hypothesis is that gene signatures can be validated when applied to new datasets, using inherent properties of PCA. Results. This validation is based on four key concepts. Coherence: elements of a gene signature should be correlated beyond chance. UNIQUENESS: the general direction of the data being examined can drive most of the observed signal...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/28262596/concept-mapping-internal-validity-a-case-of-misconceived-mapping
#16
Normand Péladeau, Christian Dagenais, Valéry Ridde
Since the early 1990s, the concept mapping technique developed by William M. K. Trochim has been widely used by evaluators for program development and evaluation and proven to be an invaluable tool for evaluators and program planners. The technique combines qualitative and statistical analysis and is designed to help identify and prioritize the components, dimensions, and particularities of a given reality. The aim of this paper is to propose an alternative way of conducting the statistical analysis to make the technique even more useful and the results easier to interpret...
February 11, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28262203/development-and-evaluation-of-a-trauma-decision-making-simulator-in-oculus-virtual-reality
#17
Cuan M Harrington, Dara O Kavanagh, John F Quinlan, Donncha Ryan, Patrick Dicker, Dara O'Keeffe, Oscar Traynor, Sean Tierney
BACKGROUND: Consumer-available virtual-reality technology was launched in 2016 with strong foundations in the entertainment-industry. We developed an innovative medical-training simulator on the Oculus™ Gear-VR platform. This novel application was developed utilising internationally recognised Advanced Trauma Life Support (ATLS) principles, requiring decision-making skills for critically-injured virtual-patients. METHODS: Participants were recruited in June, 2016 at a single-centre trauma-course (ATLS, Leinster, Ireland) and trialled the platform...
February 10, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28261399/validity-and-reliability-of-a-tool-to-assess-quality-improvement-knowledge-and-skills-in-pediatrics-residents
#18
Stephanie K Doupnik, Sonja I Ziniel, Eric W Glissmeyer, James M Moses
BACKGROUND : Residency programs are expected to educate residents in quality improvement (QI). Effective assessments are needed to ensure residents gain QI knowledge and skills. Limitations of current tools include poor interrater reliability and requirement for scorer training. OBJECTIVE : To provide evidence for the validity of the Assessment of Quality Improvement Knowledge and Skills (AQIKS), which is a new tool that provides a summative assessment of pediatrics residents' ability to recall QI concepts and apply them to a clinical scenario...
February 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28260833/development-of-noise-controls-for-longwall-shearer-cutting-drums
#19
Hugo E Camargo, Amanda S Azman, Lynn Alcorn
Noise-induced hearing loss is the second most pervasive disease in the mining industry. The exposure of miners to noise levels above the permissible exposure level results in hearing loss of approximately 80% of coal miners by retirement age. In addition, between 2002 and 2011, approximately 48% of longwall shearer operators were overexposed in coal mines in the United States. Previous research identified the two rotating cutting drums used by the longwall shearer to extract coal as the most significant sound-radiating components...
September 1, 2016: Noise Control Engineering Journal
https://www.readbyqxmd.com/read/28255294/multilevel-pharmacokinetics-driven-modeling-of-metabolomics-data
#20
Emilia Daghir-Wojtkowiak, Paweł Wiczling, Małgorzata Waszczuk-Jankowska, Roman Kaliszan, Michał Jan Markuszewski
INTRODUCTION: Multilevel modeling is a quantitative statistical method to investigate variability and relationships between variables of interest, taking into account population structure and dependencies. It can be used for prediction, data reduction and causal inference from experiments and observational studies allowing for more efficient elucidation of knowledge. OBJECTIVES: In this study we introduced the concept of multilevel pharmacokinetics (PK)-driven modelling for large-sample, unbalanced and unadjusted metabolomics data comprising nucleoside and creatinine concentration measurements in urine of healthy and cancer patients...
2017: Metabolomics: Official Journal of the Metabolomic Society
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