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https://www.readbyqxmd.com/read/29439429/plane-wave-sh%C3%A2-piezoceramic-transduction-optimized-using-geometrical-parameters
#1
Guillaume Boivin, Martin Viens, Pierre Belanger
Structural health monitoring is a prominent alternative to the scheduled maintenance of safety-critical components. The nondispersive nature as well as the through-thickness mode shape of the fundamental shear horizontal guided wave mode (SH 0 ) make it a particularly attractive candidate for ultrasonic guided wave structural health monitoring. However, plane wave excitation of SH 0 at a high level of purity remains challenging because of the existence of the fundamental Lamb modes (A 0 and S 0 ) below the cutoff frequency thickness product of high-order modes...
February 10, 2018: Sensors
https://www.readbyqxmd.com/read/29437511/computer-simulation-and-optimization-of-cranial-vault-distraction
#2
Michael J Foley, Patrick S Cottler, Silvia S Blemker, Arlen D Denny, Jonathan S Black
OBJECTIVE: The objective of this study was to validate the proof of concept of a computer-simulated cranial distraction, demonstrating accurate shape and end volume. DESIGN: Detailed modeling was performed on pre- and postoperative computed tomographic (CT) scans to generate accurate measurements of intracranial volume. Additionally, digital distraction simulations were performed on the preoperative scan and the resultant intracranial volume and shape were evaluated...
March 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29433835/towards-automated-detection-semi-quantification-and-identification-of-microbial-growth-in-clinical-bacteriology-a-proof-of-concept
#3
Antony Croxatto, Raphaël Marcelpoil, Cédrick Orny, Didier Morel, Guy Prod'hom, Gilbert Greub
BACKGROUND: Automation in microbiology laboratories impacts management, workflow, productivity and quality. Further improvements will be driven by the development of intelligent image analysis allowing automated detection of microbial growth, release of sterile samples, identification and quantification of bacterial colonies and reading of AST disk diffusion assays. We investigated the potential benefit of intelligent imaging analysis by developing algorithms allowing automated detection, semi-quantification and identification of bacterial colonies...
December 2017: Biomedical Journal
https://www.readbyqxmd.com/read/29433316/in-situ-target-engagement-studies-in-adherent-cells
#4
Hanna Axelsson, Helena Almqvist, Magdalena Otrocka, Michaela Vallin, Sara Lundqvist, Pia Hansson, Ulla Karlsson, Thomas Lundbäck, Brinton Seashore-Ludlow
A prerequisite for successful drugs is effective binding of the desired target protein in the complex environment of a living system. Drug-target engagement has typically been difficult to monitor in physiologically relevant models, and with current methods, especially, while maintaining spatial information. One recent technique for quantifying drug-target engagement is the cellular thermal shift assay (CETSA), in which ligand-induced protein stabilization is measured after a heat challenge. Here, we describe a CETSA protocol in live A431 cells for p38α (MAPK14), where remaining soluble protein is detected in situ using high-content imaging in 384-well, microtiter plates...
February 12, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29432327/mixed-methods-development-of-a-new-patient-reported-outcome-instrument-for-chronic-low-back-pain-part-1-the-patient-assessment-for-low-back-pain-symptoms-pal-s
#5
Mona L Martin, Steven I Blum, Hiltrud Liedgens, Donald M Bushnell, Kelly P McCarrier, Noël V Hatley, Abhilasha Ramasamy, Rainer Freynhagen, Mark Wallace, Charles Argoff, Mariёlle Eerdekens, Maurits Kok, Donald L Patrick
We describe the mixed-methods (qualitative and quantitative) development and preliminary validation of the Patient Assessment for Low Back Pain - Symptoms (PAL-S), a patient-reported outcome measure for use in chronic low back pain (cLBP) clinical trials. Qualitative methods (concept elicitation, cognitive interviews) were used to identify and refine symptom concepts and quantitative methods (Classical test theory, Rasch measurement theory) were used to evaluate item- and scale-level performance of the measure using an iterative approach...
February 7, 2018: Pain
https://www.readbyqxmd.com/read/29430489/posterior-cruciate-ligament-current-concepts-review
#6
REVIEW
Santiago Pache, Zachary S Aman, Mitchell Kennedy, Gilberto Yoshinobu Nakama, Gilbert Moatshe, Connor Ziegler, Robert F LaPrade
The posterior cruciate ligament (PCL) is the largest and strongest ligament in the human knee, and the primary posterior stabilizer. Recent anatomy and biomechanical studies have provided an improved understanding of PCL function. PCL injuries are typically combined with other ligamentous, meniscal and chondral injuries. Stress radiography has become an important and validated objective measure in surgical decision making and post-operative assessment. Isolated grade I or II PCL injuries can usually be treated non-operatively...
January 2018: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29430202/specialty-training-s-organizational-readiness-for-curriculum-change-storc-validation-of-a-questionnaire
#7
Lindsay Bank, Mariëlle Jippes, Jimmie Leppink, Albert Jja Scherpbier, Corry den Rooyen, Scheltus J van Luijk, Fedde Scheele
Background: The field of postgraduate medical education (PGME) is continuously evolving as a result of social demands and advancing educational insights. Change experts contend that organizational readiness for change (ORC) is a critical precursor for successful implementation of change initiatives. However, in PGME, assessing change readiness is rarely considered while it could be of great value for managing educational change such as curriculum change. Therefore, in a previous Delphi study the authors developed an instrument for assessing ORC in PGME: Specialty Training's Organizational Readiness for curriculum Change (STORC)...
2018: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29428061/classification-of-cancer-cells-using-computational-analysis-of-dynamic-morphology
#8
Mohammad R Hasan, Naeemul Hassan, Rayan Khan, Young-Tae Kim, Samir M Iqbal
BACKGROUND AND OBJECTIVE: Detection of metastatic tumor cells is important for early diagnosis and staging of cancer. However, such cells are exceedingly difficult to detect from blood or biopsy samples at the disease onset. It is reported that cancer cells, and especially metastatic tumor cells, show very distinctive morphological behavior compared to their healthy counterparts on aptamer functionalized substrates. The ability to quickly analyze the data and quantify the cell morphology for an instant real-time feedback can certainly contribute to early cancer diagnosis...
March 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29426030/an-empirical-assessment-of-adjustment-disorder-as-proposed-for-icd-11-in-a-general-population-sample-of-israel
#9
Louisa Lorenz, Philip Hyland, Andreas Maercker, Menachem Ben-Ezra
BACKGROUND: A new diagnostic concept of Adjustment Disorder (AjD) was proposed for inclusion in the International Classification of Diseases, 11th version (ICD-11). However, the symptom structure of AjD is poorly understood. The aim of the present study was to investigate the dimensionality of AjD as a stress-response syndrome. METHODS: A general population sample of the Israeli population (N = 1003) completed the Adjustment Disorder - New Module 20 and the WHO-5 Wellbeing Scale...
February 6, 2018: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29422950/a-feasible-diagnostic-approach-for-the-translocation-carrier-from-the-indication-of-products-of-conception
#10
Ye-Qing Qian, Xiao-Ying Fu, Xiao-Qing Wang, Yu-Qin Luo, Min Chen, Kai Yan, Yan-Mei Yang, Bei Liu, Li-Ya Wang, Ying-Zhi Huang, Hong-Ge Li, Hang-Yi Pan, Fan Jin, Min-Yue Dong
Background: Chromosome translocations are rare but frequently associated with infertility. The objective of this study is to investigate the feasibility of using chromosomal microarray analysis (CMA) on products of conception (POC) samples as an indicator of parental balanced translocation. From January 2011 to December 2016, CMA using Affymetrix Cytoscan™750K array was performed on 1294 POC samples in our hospital. Karyotyping and fluorescence in situ hybridization (FISH) using parental blood samples were performed to validate the origin of subchromosomal copy number variations (CNVs)...
2018: Molecular Cytogenetics
https://www.readbyqxmd.com/read/29420437/objectively-differentiating-movement-patterns-between-elite-and-novice-athletes
#11
Gwyneth B Ross, Brittany Dowling, Nikolaus F Troje, Steven L Fischer, Ryan B Graham
INTRODUCTION: Movement screens are frequently used to identify abnormal movement patterns that may increase risk of injury or hinder performance. Abnormal patterns are often detected visually based on the observations of a coach or clinician. Quantitative, or data-driven methods can increase objectivity, remove issues related to inter-rater reliability and offer the potential to detect new and important features that may not be observable by the human eye. Applying principal components analysis (PCA) to whole-body motion data may provide an objective data-driven method to identify unique and statistically important movement patterns, an important first step to objectively characterize optimal patterns or identify abnormalities...
February 5, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29416847/development-and-validation-of-a-standardized-double-blind-placebo-controlled-food-challenge-matrix-for-raw-hazelnuts
#12
Marjolein Vandekerckhove, Bart Van Droogenbroeck, Marc De Loose, Katleen Coudijzer, Marc Coppens, Philippe Gevaert, Hilde Lapeere
Background: Double-blind, placebo-controlled food challenge (DBPCFC) is considered the gold standard for food allergy diagnosis. However, this test is rarely performed routinely in clinical practice because of various practical issues, e.g. the lack of a standardized matrix preparation. The aim of this study was to develop and validate a convenient DBPCFC matrix, that can easily be implemented in daily clinical practice. The focus of this study was the blinding of hazelnuts, whereby the hazelnuts retained as much as possible their allergenicity and could be mixed homogenously in low-doses to the matrices...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29413500/evaluation-of-a-respiratory-symptom-diary-for-clinical-studies-of-idiopathic-pulmonary-fibrosis
#13
Elizabeth Dansie Bacci, Sean O'Quinn, Nancy Kline Leidy, Lindsey Murray, Margaret Vernon
BACKGROUND: There are no validated patient diaries for evaluating respiratory symptoms in idiopathic pulmonary fibrosis (IPF). PURPOSE: To evaluate the performance properties of the chronic obstructive pulmonary disease (COPD) Evaluating Respiratory Symptoms™ (E-RS™: COPD) measure in patients with IPF. METHODS: Concept elicitation and cognitive interviews were conducted with IPF patients to evaluate content validity, including comprehensiveness, relevance, and interpretability of E-RS™ items in this patient population...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29412098/leadership-in-crisis-situations-merging-the-interdisciplinary-silos
#14
Hugo Paquin, Ilana Bank, Meredith Young, Lily H P Nguyen, Rachel Fisher, Peter Nugus
Purpose Complex clinical situations, involving multiple medical specialists, create potential for tension or lack of clarity over leadership roles and may result in miscommunication, errors and poor patient outcomes. Even though copresence has been shown to overcome some differences among team members, the coordination literature provides little guidance on the relationship between coordination and leadership in highly specialized health settings. The purpose of this paper is to determine how different specialties involved in critical medical situations perceive the role of a leader and its contribution to effective crisis management, to better define leadership and improve interdisciplinary leadership and education...
February 5, 2018: Leadership in Health Services
https://www.readbyqxmd.com/read/29408832/quantitative-primary-tumor-indocyanine-green-measurements-predict-osteosarcoma-metastatic-lung-burden-in-a-mouse-model
#15
Mitchell S Fourman, Adel Mahjoub, Jon B Mandell, Shibing Yu, Jessica C Tebbets, Jared A Crasto, Peter E Alexander, Kurt R Weiss
BACKGROUND: Current preclinical osteosarcoma (OS) models largely focus on quantifying primary tumor burden. However, most fatalities from OS are caused by metastatic disease. The quantification of metastatic OS currently relies on CT, which is limited by motion artifact, requires intravenous contrast, and can be technically demanding in the preclinical setting. We describe the ability for indocyanine green (ICG) fluorescence angiography to quantify primary and metastatic OS in a previously validated orthotopic, immunocompetent mouse model...
January 17, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29403607/obstacles-facing-evidence-based-medicine-in-physical-medicine-and-rehabilitation-from-opinion-and-knowledge-to-practice
#16
Seyed Ahmad Raeissadat, Mohammad Hasan Bahrami, Seyed Mansoor Rayegani, Hossein Hassanabadi, Marzieh Babaee, Sharif Najafi, Reza Aghabozorgi
Background: Evidence-based medicine (EBM) is a new approach to medicine which can guide clinical services toward effective and beneficial results with the least side effects or errors. Up to now, there have been few available articles about specialists' EBM status, specifically the status of physiatrists in the area of EBM. Objective: To determine the present status of physiatrists' attitudes, knowledge and skill in the area of EBM and the existing obstacles. Methods: The cross-sectional study was performed in 2014 among physiatrists in Iran...
November 2017: Electronic Physician
https://www.readbyqxmd.com/read/29402652/fall-risk-increasing-drugs-a-systematic-review-and-meta-analysis-ii-psychotropics
#17
Lotta J Seppala, Anne M A T Wermelink, Max de Vries, Kimberley J Ploegmakers, Esther M M van de Glind, Joost G Daams, Nathalie van der Velde
BACKGROUND AND OBJECTIVE: Falls are a major public health problem in older adults. Earlier studies showed that psychotropic medication use increases the risk of falls. The aim of this study is to update the current knowledge by providing a comprehensive systematic review and meta-analysis on psychotropic medication use and falls in older adults. METHODS AND DESIGN: This study is a systematic review and meta-analysis. A search was conducted in Medline, PsycINFO, and Embase...
February 2, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29401263/contractual-health-services-performance-agreements-for-responsive-health-systems-from-conception-to-implementation-in-the-case-of-qatar
#18
Huda Al-Katheeri, Fadi El-Jardali, Nour Ataya, Noura Abdulla Salem, Nader Abbas Badr, Diana Jamal
Objective: Despite their use worldwide, strategy-based performance management is limited in the Eastern Mediterranean Region. This article explores Qatar's experience, the first from the Region, in implementing contractual agreements between healthcare providers and the regulator-Ministry of Public Health-to align strategy, performance and accountabilities. Design: mixed-methods including tools development and pilot-testing, guided by performance management cycle with a focus on knowledge translation and key principles: feasibility; mandatory participation; participatory approach through Steering Committee...
February 1, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29398308/transthoracic-ultrasound-evaluation-of-arch-and-descending-thoracic-aortic-pathology
#19
Fabrizio D'Abate, Dare Oladokun, Angelo La Leggia, Robert Hinchliffe, Matthew Thompson, Peter Holt, Jorg de Bruin, Ian Loftus, Benjamin Patterson
BACKGROUND: Duplex ultrasonography (DUS) currently has limited applicability in the diagnosis and surveillance of thoracic aortic pathologies because of associated limitations. This study investigates the feasibility of using an optimised DUS protocol to detect descending thoracic aortic pathology. METHODS: Forty patients were scanned (20 cases and 20 controls). All patients but one had a technically adequate assessment of the thoracic aorta (at least one view of the descending thoracic aorta)...
February 2, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29395257/assessing-health-related-quality-of-life-in-primary-sj%C3%A3-gren-s-syndrome-the-pss-qol
#20
Angelika Lackner, Martin H Stradner, Josef Hermann, Julia Unger, Tanja Stamm, Winfried B Graninger, Christian Dejaco
OBJECTIVES: To develop a questionnaire for the assessment of health-related quality of life (HRQL) in primary Sjögren's syndrome (PSS), and to test its psychometric properties. METHODS: Based on the concepts of a previous qualitative study, a questionnaire for the assessment of HRQL in PSS (PSS-QoL) was developed. Psychometric testing of PSS-QoL was performed after revising the first draft with feedback of patients (n = 6) and clinicians (n = 4). Convergent construct validity was assessed by correlating the score with the EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI), EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) and Euro-QoL 5D (EQ-5D)...
November 27, 2017: Seminars in Arthritis and Rheumatism
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