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Validity concepts performance

Emidio Olivieri, Giacinto Barresi, Darwin G Caldwell, Leonardo S Mattos
Haptics has proven to be highly beneficial in surgical robotics, bringing enhanced safety and precision by complementing the surgeon's visual channel. However, most of the research body in this context is dedicated to applications involving traditional "cold steel" surgical instruments. This paper proposes to bring the benefits of haptics to contactless surgeries, and presents a novel method to achieve this. The specific case of robot-assisted laser microsurgery is investigated. Here, a fictitious force feedback is created through stereoscopic visualization and 3D reconstruction, allowing the surgeon to sense the surgical area haptically while controlling a non-contact surgical laser...
April 2018: IEEE Transactions on Haptics
Orlagh Farmer, Sarahjane Belton, Wesley O'Brien
This study examines the relationship between actual fundamental motor skill (FMS) proficiency, perceived motor confidence and competence, and physical activity (PA) among female children ( n = 160; mean age = 10.69 ± 1.40 years). The Test of Gross Motor Development-2nd Edition (TGMD-2) was used to assess seven FMSs (locomotor, object-control, and stability). Motor confidence and competence were assessed using a valid skill-specific scale, and a modified version of the Self-Perception Profile for Children. PA levels were assessed using self-report (PA Questionnaire for Older Children (PAQ-C)) and classified as low, moderate, and high active...
September 27, 2017: Sports (Basel)
Cristiano Ialongo, Sergio Bernardini
There is a compelling need for quality tools that enable effective control of the extra-analytical phase. In this regard, Six Sigma seems to offer a valid methodological and conceptual opportunity, and in recent times, the International Federation of Clinical Chemistry and Laboratory Medicine has adopted it for indicating the performance requirements for non-analytical laboratory processes. However, the Six Sigma implies a distinction between short-term and long-term quality that is based on the dynamics of the processes...
June 18, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
Hao Liu, Wang He, Bo Wang, Kewei Xu, Jinli Han, Junjiong Zheng, Jun Ren, Lin Shao, Shiping Bo, Sijia Lu, Tianxin Lin, Jian Huang
BACKGROUND: The gold standard for bladder cancer detection is cystoscopy, which is an invasive procedure that causes discomfort in patients. The currently available non-invasive approaches either show limited sensitivity in low-grade tumours or possess unsatisfying specificity. The aim of the present study is to develop a new non-invasive strategy based on chromosomal imbalance levels to detect bladder cancer effectively. METHODS: We enrolled 74 patients diagnosed with bladder cancer (BC), 51 healthy participants and 27 patients who were diagnosed with non-malignant urinary disease (UD)...
June 15, 2018: BMC Cancer
Christoph Schneider, Florian Hanakam, Thimo Wiewelhove, Alexander Döweling, Michael Kellmann, Tim Meyer, Mark Pfeiffer, Alexander Ferrauti
A comprehensive monitoring of fitness, fatigue, and performance is crucial for understanding an athlete's individual responses to training to optimize the scheduling of training and recovery strategies. Resting and exercise-related heart rate measures have received growing interest in recent decades and are considered potentially useful within multivariate response monitoring, as they provide non-invasive and time-efficient insights into the status of the autonomic nervous system (ANS) and aerobic fitness. In team sports, the practical implementation of athlete monitoring systems poses a particular challenge due to the complex and multidimensional structure of game demands and player and team performance, as well as logistic reasons, such as the typically large number of players and busy training and competition schedules...
2018: Frontiers in Physiology
Patrick Manu, Anush Poghosyan, Ibrahim Mark Mshelia, Samuel Tekena Iwo, Abdul-Majeed Mahamadu, Krzysztof Dziekonski
PURPOSE: Design for safety (DfS) of workers is amongst the prominent ways of tackling poor occupational safety and health (OSH) performance in construction. However, in developing countries there is an extremely limited research on DfS. This study thus makes an important contribution to the subject of DfS in developing countries by specifically examining the awareness and practice of DfS amongst architects within the construction sector of Nigeria. MATERIALS AND METHODS: A survey of architects, yielding 161 valid responses, was conducted...
June 14, 2018: International Journal of Occupational Safety and Ergonomics: JOSE
Lakshmi Ananthakrishnan, Xinhui Duan, Prabhakar Rajiah, Todd C Soesbe, Matthew A Lewis, Yin Xi, Julia R Fielding, Robert E Lenkinski, John R Leyendecker, Suhny Abbara
PURPOSE: Spectral detector computed tomography (SDCT) is a new CT technology that uses a dual-layer detector to perform energy separation. We aim to assess 3 clinical concepts using a phantom model: noise profile across the virtual monoenergetic (VME) spectrum, accuracy of iodine quantification, and virtual noncontrast (VNC) reconstructions' ability to remove iodine contribution to attenuation. METHODS: Six vials containing varying concentrations of iodinated contrast (0-6 mg/mL) diluted in water were placed in a water bath and scanned on an SDCT scanner...
June 12, 2018: Journal of Computer Assisted Tomography
Gabriela Vera-Lozada, Priscilla Segges, Claudio Gustavo Stefanoff, Mário Henrique M Barros, Gerald Niedobitek, Rocio Hassan
The search for clinically relevant molecular markers in classical Hodgkin lymphoma (cHL) is hampered by the histopathological complexity of the disease, resulting from the admixture of a small number of neoplastic Hodgkin and Reed-Sternberg (H-RS) cells with an abundant and heterogeneous microenvironment. In this study, we evaluated gene expression profiles of 11 selected genes previously proposed as a molecular score for adult cHL, aiming to validate its application in the pediatric setting. Assays were performed by RT-qPCR from formalin-fixed paraffin-embedded (FFPE) lymph nodes in 80 patients with cHL...
June 14, 2018: Hematological Oncology
Sebastien Rinaldetti, Eugen Rempel, Thomas Stefan Worst, Markus Eckstein, Annette Steidler, Cleo Aaron Weiss, Christian Bolenz, Arndt Hartmann, Philipp Erben
Background: Transcriptome expression studies identified distinct muscle invasive bladder cancer (MIBC) subtypes closely related with breast cancer subclasses. Here we developed a sensitive quantification method for MIBC subclassification (luminal, basal, p53-like). In addition, the subtype specific expression of drug targets has been investigated. Methods: Absolute quantification (nCounter) of a 64-gene panel was performed on MIBC patients (n=47) treated exclusively with radical cystectomy (RC)...
May 25, 2018: Oncotarget
A R Podgorsak, A C Venkataraman, S V Setlur Nagesh, D R Bednarek, S Rudin, A Siddiqui, C N Ionita
The imaging of endovascular devices during neurovascular procedures such as the coiling of aneurysms guided with CBCT imaging may be challenging due to the presence of highly attenuating materials such as platinum in the coil and stent marker, nickel-titanium in the stent, iodine in the contrast agent, and tantalum in the embolization agent. The use of dual-energy imaging followed by a basis material decomposition image processing-scheme may improve the feature separation and recognition. Two sets of testing were performed to validate this concept...
February 2018: Proceedings of SPIE
Andrea C Tricco, Wasifa Zarin, Erin Lillie, Serena Jeblee, Rachel Warren, Paul A Khan, Reid Robson, Ba' Pham, Graeme Hirst, Sharon E Straus
BACKGROUND: A scoping review to characterize the literature on the use of conversations in social media as a potential source of data for detecting adverse events (AEs) related to health products. METHODS: Our specific research questions were (1) What social media listening platforms exist to detect adverse events related to health products, and what are their capabilities and characteristics? (2) What is the validity and reliability of data from social media for detecting these adverse events? MEDLINE, EMBASE, Cochrane Library, and relevant websites were searched from inception to May 2016...
June 14, 2018: BMC Medical Informatics and Decision Making
Bhargav Patel, Arvind G Jangid, B N Suhagia, Nirmal Desai
An isotope dilution selective and sensitive high-performance liquid chromatography-tandem mass spectrometry (LC-ESI-MS/MS) method has been developed for the simultaneous determination of hydrochlorothiazide (HCTZ) and ramipril in human plasma through a new concept of periodical polarity switching. Extraction of HCTZ, ramipril and their deuterated analogs as internal standards (ISs) was carried out from 150 μL of human plasma by solid-phase extraction method. Chromatographic separation of analytes was performed on Hypurity C18 (150 mm × 4...
June 12, 2018: Journal of Chromatographic Science
Donald M Bushnell, Steven I Blum, Hiltrud Liedgens, Mona L Martin, Rainer Freynhagen, Mark Wallace, Charles Argoff, Mariёlle Eerdekens, Maurits Kok, Donald L Patrick
We describe qualitative and quantitative development and preliminary validation of the Patient Assessment for Low Back Pain - Impacts (PAL-I), a patient-reported outcome measure for use in chronic low back pain (cLBP) clinical trials. Concept elicitation and cognitive interviews (qualitative methods) were used to identify and refine symptom concepts. Classical test theory and Rasch measurement theory (quantitative methods) were used to evaluate item-level and scale-level performance of the PAL-I using an iterative approach between qualitative and quantitative methods...
June 7, 2018: Pain
B X Chen, Q Ou, M X Pan
Objective: To investigate the treatment acceptance in patients with obstructive sleep apnea (OSA) and its influence factors. Methods: This cross-sectional survey recruited OSA patients diagnosed at sleep center in Guangdong General Hospital from January 2014 to December 2015. By phone follow-up, a pre-designed questionnaire was performed for all adults, which composed of the following sections: treatment or none, treatment method, reason for non-treatment, revisit or none. Results: From 524 OSA patients with completed contact information, 480 (91...
May 29, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Zdena Malá, Petr Gebauer
Electrophoretic focusing on inverse electromigration dispersion (EMD) gradient is a new analytical technique based on a unique separation principle where weak non-amphoteric ionogenic species are focused, separated and transported to the detector by an EMD profile of suitable properties. The present work extends the theoretical description of this method by introducing the concept of resolution and deriving the fundamental equation expressing resolution as function of basic system parameters. The results indicate that at constant current operation, resolution is proportional to the square root of time...
June 1, 2018: Journal of Chromatography. A
Molly Day, Kyle Hancock, Natalie Glass, Matthew Bollier
Outcome instruments have become an essential part of the evaluation of functional recovery after anterior cruciate ligament (ACL) reconstruction. Although the clinical examination provides important objective information to assess graft integrity, stability, range of motion, and strength, these measurements do not take the patient's perception into account. There are many knee outcome instruments, and it is challenging for surgeons to understand how to interpret clinical research and utilize these measures in a practical way...
May 2018: American Journal of Orthopedics
Jaehyun Shin, Yongmin Zhong, Denny Oetomo, Chengfan Gu
This paper presents a new nonlinear filtering method based on the Hunt-Crossley model for online nonlinear soft tissue characterization. This method overcomes the problem of performance degradation in the unscented Kalman filter due to contact model error. It adopts the concept of Mahalanobis distance to identify contact model error, and further incorporates a scaling factor in predicted state covariance to compensate identified model error. This scaling factor is determined according to the principle of innovation orthogonality to avoid the cumbersome computation of Jacobian matrix, where the random weighting concept is adopted to improve the estimation accuracy of innovation covariance...
May 21, 2018: Sensors
Andrea Lienhardt, Franziska Rabenschlag, Eva-Maria Panfil
The practice of special observation in adults in the German-speaking part of Switzerland - a descriptive cross-sectional study Abstract. INTRODUCTION: Psychiatric Special Observation (PSO) is an intervention often used by nurses to prevent service users of harming themselves or to protect others. The intervention ranges between control and therapy and is resource intensive. Despite the widespread use of PSO, there is still no data on the practice of the intervention in Switzerland. AIM: What is the current practice of PSO in adults in psychiatric hospitals in the German-speaking part of Switzerland? METHOD: Descriptive cross-sectional study...
June 8, 2018: Pflege
Jorge Castizo-Olier, Alfredo Irurtia, Monèm Jemni, Marta Carrasco-Marginet, Raúl Fernández-García, Ferran A Rodríguez
BACKGROUND: Bioelectrical impedance vector analysis (BIVA) is a general concept that includes all methodologies used in the analysis of the bioelectrical vector, whereas the "classic" BIVA is a patented methodology included among these methods of analysis. Once this was clarified, the systematic review of the literature provides a deeper insight into the scope and range of application of BIVA in sport and exercise. OBJECTIVE: The main goal of this work was to systematically review the sources on the applications of BIVA in sport and exercise and to examine its usefulness and suitability as a technique for the evaluation of body composition, hydration status, and other physiological and clinical relevant characteristics, ultimately to trace future perspectives in this growing area, including a proposal for a research agenda...
2018: PloS One
Anne F Klassen, Natalia Ziolkowski, Lily R Mundy, H Catherine Miller, Alison McIlvride, Allison DiLaura, Joel Fish, Andrea L Pusic
Background: Every year millions of individuals acquire scars. A literature review of patient-reported outcome (PRO) instruments identified content limitations in existing scar-specific measures. The aim of this study was to develop a new PRO instrument called SCAR-Q for children and adults with surgical, traumatic, and burn scars. Methods: We performed a secondary analysis of the qualitative datasets used in the development of PRO instruments for plastic and reconstructive surgery, that is, BREAST-Q, FACE-Q, BODY-Q, and CLEFT-Q...
April 2018: Plastic and Reconstructive Surgery. Global Open
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