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Validity concepts performance

Kevin L Kamermans, Wim Pouw, Fred W Mast, Fred Paas
Is visual reinterpretation of bistable figures (e.g., duck/rabbit figure) in visual imagery possible? Current consensus suggests that it is in principle possible because of converging evidence of quasi-pictorial functioning of visual imagery. Yet, studies that have directly tested and found evidence for reinterpretation in visual imagery, allow for the possibility that reinterpretation was already achieved during memorization of the figure(s). One study resolved this issue, providing evidence for reinterpretation in visual imagery (Mast and Kosslyn, Cognition 86:57-70, 2002)...
December 14, 2017: Psychological Research
Robert Kronstrand, Malin Forsman, Markus Roman
Liquid chromatographic methods coupled to high resolution mass spectrometry are increasingly used to identify compounds in various matrices including hair but there are few recommendations regarding the parameters and their criteria to identify a compound. In this study we present a method for the identification and quantification of a range of drugs and discuss the parameters used to identify a compound with high resolution mass spectrometry. Drugs were extracted from hair by incubation in a buffer:solvent mixture at 37°C during 18h...
December 8, 2017: Forensic Science International
Shan Nan, Pieter Van Gorp, Xudong Lu, Uzay Kaymak, Hendrikus Korsten, Richard Vdovjak, Huilong Duan
BACKGROUND: Safety checklist is a type of cognitive tool enforcing short term memory of medical workers with the purpose of reducing medical errors caused by overlook and ignorance. To facilitate the daily use of safety checklists, computerized systems embedded in the clinical workflow and adapted to patient-context are increasingly developed. However, the current hard-coded approach of implementing checklists in these systems increase the cognitive efforts of clinical experts and coding efforts for informaticists...
December 12, 2017: BMC Medical Informatics and Decision Making
Mirtes Loeschner Leichsenring, Eliane Molina Psaltikidis, Márcio Jansen de Oliveira Figueiredo, Maria Luiza Moretti, Plínio Trabasso
PURPOSE: Since the Brazilian current legislation permits the reuse of single-use devices under a validated processing protocol, the main purpose of our study was to develop and validate a method for reusing non-irrigated electrophysiology catheter (EC). METHODS: Manual and mechanical processing by ultrasonic washer was associated with the use of enzymatic solution and hydrogen peroxide with a final rinse with filtered water. Validation of the cleaning process, as well as catheter integrity, was done by observing the ECs in stereoscopic microscope at ×60 magnification, followed by HemoCheck-S® (HCS) test to monitor the presence of residual blood on their surfaces...
December 11, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Dee Dee Wang, Marvin H Eng, Adam B Greenbaum, Eric Myers, Michael Forbes, Patrick Karabon, Milan Pantelic, Thomas Song, Jeff Nadig, Mayra Guerrero, William W O'Neill
OBJECTIVE: Demonstrate proof-of-concept validation of a computed tomography (CT) computer-aided design prediction modeling tool to identify patients at risk for left ventricular outflow tract (LVOT) obstruction in transcatheter mitral valve replacement (TMVR). BACKGROUND: LVOT obstruction is a significant and even fatal consequence of TMVR. METHODS: From August 2013 to August 2017, 38 patients in 5 centers underwent TMVR with compassionate use of balloon-expandable valves for severe mitral valve dysfunction because of degenerative surgical mitral ring, bioprosthesis, or severe native mitral stenosis from to severe mitral annular calcification...
December 11, 2017: Catheterization and Cardiovascular Interventions
Benjamin S Glicksberg, Riccardo Miotto, Kipp W Johnson, Khader Shameer, Li Li, Rong Chen, Joel T Dudley
Accurate and robust cohort definition is critical to biomedical discovery using Electronic Health Records (EHR). Similar to prospective study designs, high quality EHR-based research requires rigorous selection criteria to designate case/control status particular to each disease. Electronic phenotyping algorithms, which are manually built and validated per disease, have been successful in filling this need. However, these approaches are time-consuming, leading to only a relatively small amount of algorithms for diseases developed...
2018: Pacific Symposium on Biocomputing
Julie Bensimon Etzol, Marco Valente, Sandrine Altmeyer, Caroline Bettencourt, Samuel Bouvet, Guillaume Cosler, François Desangles, Michel Drouet, Fabrice Entine, Francis Hérodin, Flora Jourquin, Yannick Lecompte, Patrick Martigne, Xavier Michel, Jérôme Pateux, Nicolas Ugolin, Sylvie Chevillard
DosiKit is a new field-radiation biodosimetry immunoassay for rapid triage of individuals exposed to external total-body radiation. Here, we report on the validation of this immunoassay in human blood cell extracts 0.5 h after in vitro exposure to 137Cs gamma rays, using γ-H2AX analysis. First, calibration curves were established for five donors at doses ranging from 0 to 10 Gy and dose rates ranging from ∼0.8 to ∼3 Gy/min. The calibration curves, together with a γ-H2AX peptide scale, enabled the definition of inter-experimental correction factors...
December 7, 2017: Radiation Research
Aurelien L Noyer, Jorge E Esteves, Oliver P Thomson
Background: Diagnostic reasoning refers to the cognitive processes by which clinicians formulate diagnoses. Despite the implications for patient safety and professional identity, research on diagnostic reasoning in osteopathy remains largely theoretical. The aim of this study was to investigate the influence of perceived task difficulty on the diagnostic reasoning of students osteopaths. Methods: Using a single-blinded, cross sectional study design, sixteen final year pre-registration osteopathy students diagnosed two standardized cases under two context conditions (complex versus control)...
2017: Chiropractic & Manual Therapies
Marijn van Vliet, Marc M Van Hulle, Riitta Salmelin
Modern multivariate methods have enabled the application of unsupervised techniques to analyze neurophysiological data without strict adherence to predefined experimental conditions. We demonstrate a multivariate method that leverages priming effects on the evoked potential to perform hierarchical clustering on a set of word stimuli. The current study focuses on the semantic relationships that play a key role in the organization of our mental lexicon of words and concepts. The N400 component of the event-related potential is considered a reliable neurophysiological response that is indicative of whether accessing one concept facilitates subsequent access to another (i...
December 6, 2017: Journal of Cognitive Neuroscience
Roy J P Hendrikx, Marieke D Spreeuwenberg, Hanneke W Drewes, Dirk Ruwaard, Caroline A Baan
Population health management initiatives are introduced to transform health and community services by implementing interventions that combine various services and address the continuum of health and well-being of populations. Insight is required into a population's health to evaluate implementation of these initiatives. This study aims to determine the performance of commonly used instruments for measuring a population's experienced health and explores the assessed concepts of population health. Survey-based Short Form 12, version 2 (SF12, health status), Patient Activation Measure 13 (PAM13), and Kessler 10 (K10, psychological distress) data of 3120 respondents was used...
December 6, 2017: Population Health Management
Matthias Müller, Wolfram Meusel, Ute Husemann, Gerhard Greller, Matthias Kraume
The application of biocalorimetry to fermentation processes offers advantageous insights, while being less complex compared to other,sophisticated PAT solutions. Although the general concept is established,calorimetric methods vary in detail. In this work, a special approach,called heat compensation calorimetry, was applied to an E. coli fed-batch process. Much work has been done for batch processes, proving the validity and accuracy of this calorimetric mode. However, the adaption of this strategy to fed-batch processes has some implications...
December 2, 2017: Journal of Biotechnology
Felipe Mattioni Maturana, Federico Y Fontana, Silvia Pogliaghi, Louis Passfield, Juan M Murias
In cycling, critical power (CP) and work above CP (W') can be estimated through linear and nonlinear models. Despite the concept of CP representing the upper boundary of sustainable exercise, overestimations may be made as the models possess inherent limitations and the protocol design is not always appropriate. OBJECTIVES: To measure and compare CP and W' through the exponential (CPexp), 3-parameter hyperbolic (CP3-hyp), 2-parameter hyperbolic (CP2-hyp), linear (CPlinear), and linear 1/time (CP1/time) models, using different combinations of TTE trials of different durations (approximately 1-20min)...
November 29, 2017: Journal of Science and Medicine in Sport
Renan Belli, Michael Wendler, José I Zorzin, Ulrich Lohbauer
BACKGROUND: An important tool in materials research, development and characterization regarding mechanical performance is the testing of fracture toughness. A high level of accuracy in executing this sort of test is necessary, with strict requirements given in extensive testing standard documents. Proficiency in quality specimen fabrication and test requires practice and a solid theoretical background, oftentimes overlooked in the dental community. AIMS: In this review we go through some fundamentals of the fracture mechanics concepts that are relevant to the understanding of fracture toughness testing, and draw attention to critical aspects of practical nature that must be fulfilled for validity and accuracy in results...
December 1, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
Marleen Smits, Ellen Keizer, Paul Ram, Paul Giesen
BACKGROUND: Telephone triage is a core but vulnerable part of the care process at out-of-hours general practitioner (GP) cooperatives. In the Netherlands, different instruments have been used for assessing the quality of telephone triage. These instruments focussed mainly on communicational aspects, and less on the medical quality of triage decisions. Our aim was to develop and test a minimum set of items to assess the quality of telephone triage. METHODS: A national survey among all GP cooperatives in the Netherlands was performed to examine the most important aspects of telephone triage...
December 2, 2017: BMC Health Services Research
Tilman Laubert, Hamed Esnaashari, Paul Auerswald, Anna Höfer, Michael Thomaschewski, Hans-Peter Bruch, Tobias Keck, Claudia Benecke
PURPOSE: Difficulties at the beginning of the learning curve in minimally invasive surgery (MIS) can well be overcome by simulation outside the operating room. Despite a great number of available devices, standardized, structured, and validated training curricula for video simulators are scarce. METHODS: The Lübeck Toolbox (LTB) video trainer provides six training modules and online video tutorials. Proficiency levels for the tasks were defined by performance analysis of MIS experts (n = 15)...
December 1, 2017: Langenbeck's Archives of Surgery
Yan Wang, Xieer Liang, Jinlian Yang, Hao Wang, Deming Tan, Shijun Chen, Jun Cheng, Yongpeng Chen, Jian Sun, Fan Rong, Wei Yang, Hailin Liu, Zhipeng Liu, Yongjian Zheng, Jiaen Liang, Shiying Li, Zhihong Liu, Jinlin Hou
Monitoring longitudinal non-advanced fibrosis is a more common scenario in management of chronic hepatitis B (CHB), for which however, current evaluation methods generally lack sufficient performance. We conducted a proof-of-concept study to evaluate the performance of quantitative fibrous collagen parameters (q-FP) in the assessment. Data sets from a prior CHB trial (NCT00962533) with mostly mild-to-moderate fibrosis participants were used for this study. 301 subjects with paired liver biopsies were consecutively included...
November 29, 2017: Journal of Viral Hepatitis
Taemin Oh, Justin K Scheer, Justin S Smith, Richard Hostin, Chessie Robinson, Jeffrey L Gum, Frank Schwab, Robert A Hart, Virginie Lafage, Douglas C Burton, Shay Bess, Themistocles Protopsaltis, Eric O Klineberg, Christopher I Shaffrey, Christopher P Ames
OBJECTIVE Patients with adult spinal deformity (ASD) experience significant quality of life improvements after surgery. Treatment, however, is expensive and complication rates are high. Predictive analytics has the potential to use many variables to make accurate predictions in large data sets. A validated minimum clinically important difference (MCID) model has the potential to assist in patient selection, thereby improving outcomes and, potentially, cost-effectiveness. METHODS The present study was a retrospective analysis of a multiinstitutional database of patients with ASD...
December 2017: Neurosurgical Focus
Henri Wathieu, Naiem T Issa, Aileen I Fernandez, Manisha Mohandoss, Deanna M Tiek, Jennifer L Franke, Stephen W Byers, Rebecca B Riggins, Sivanesan Dakshanamurthy
Triple negative breast cancer (TNBC) is a group of cancers whose heterogeneity and shortage of effective drug therapies has prompted efforts to divide these cancers into molecular subtypes. Our computational platform, entitled GenEx-TNBC, applies concepts in systems biology and polypharmacology to prioritize thousands of approved and experimental drugs for therapeutic potential against each molecular subtype of TNBC. Using patient-based and cell line-based gene expression data, we constructed networks to describe the biological perturbation associated with each TNBC subtype at multiple levels of biological action...
November 3, 2017: Oncotarget
Joseph P Angelo, Martijn van de Giessen, Sylvain Gioux
With almost 50% of all surgeries in the U.S. being performed as minimally invasive procedures, there is a need to develop quantitative endoscopic imaging techniques to aid surgical guidance. Recent developments in widefield optical imaging make endoscopic implementations of real-time measurement possible. In this work, we introduce a proof-of-concept endoscopic implementation of a functional widefield imaging technique called 3D single snapshot of optical properties (3D-SSOP) that provides quantitative maps of absorption and reduced scattering optical properties as well as surface topography with simple instrumentation added to a commercial endoscope...
November 1, 2017: Biomedical Optics Express
Carmen Navarro, Victor Martínez, Armando Blanco, Carlos Cano
Background: Networks have been proven effective representations for the analysis of biological data. As such, there exist multiple methods to extract knowledge from biological networks. However, these approaches usually limit their scope to a single biological entity type of interest, or they lack flexibility to analyse user-defined data. Results: We developed ProphTools, a flexible open-source command-line tool that performs prioritization on a heterogeneous network...
November 24, 2017: GigaScience
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