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https://www.readbyqxmd.com/read/28448775/exploring-electronic-medical-record-and-self-administered-medication-risk-screening-tools-in-a-primary-care-clinic
#1
Mark J Makowsky, Ken Cor, Tat Wong
BACKGROUND: Electronic medical record (EMR) screening for indicators of medication risk could improve efficiency in identifying primary care clinic patients in need of clinical pharmacist care compared with patient self-reporting. OBJECTIVES: To (a) compare the performance of an EMR medication risk assessment questionnaire (MRAQ) with a self-administered (SA) MRAQ and (b) explore each tool's ability to predict indicators of health behavior, health status, and health care utilization...
May 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28448469/distributed-data-service-for-data-management-in-internet-of-things-middleware
#2
Ruben Cruz Huacarpuma, Rafael Timoteo de Sousa Junior, Maristela Terto de Holanda, Robson de Oliveira Albuquerque, Luis Javier García Villalba, Tai-Hoon Kim
The development of the Internet of Things (IoT) is closely related to a considerable increase in the number and variety of devices connected to the Internet. Sensors have become a regular component of our environment, as well as smart phones and other devices that continuously collect data about our lives even without our intervention. With such connected devices, a broad range of applications has been developed and deployed, including those dealing with massive volumes of data. In this paper, we introduce a Distributed Data Service (DDS) to collect and process data for IoT environments...
April 27, 2017: Sensors
https://www.readbyqxmd.com/read/28447477/simultaneous-visualization-of-hydrogen-peroxide-and-water-concentrations-using-photofragmentation-laser-induced-fluorescence
#3
Kajsa Larsson, Marcus Aldén, Joakim Bood
A concept based on photofragmentation laser-induced fluorescence (PFLIF) is for the first time demonstrated for simultaneous detection of hydrogen peroxide (H2O2) and water (H2O) vapor in various mixtures containing the two constituents in a bath of argon gas. A photolysis laser pulse at 248 nm dissociates H2O2 into OH fragments, whereupon a probe pulse, delayed 100 ns and tuned to an absorption line in the A(2)Σ(+) (v = 1) ← X(2)Π(v = 0) band of OH near 282 nm, induces fluorescence. The total OH fluorescence reflects the H2O2 concentration, while its spectral shape is utilized to determine the H2O concentration via a model predicting the ratio between the fluorescence intensities of the A(2)Σ(+) (v = 1) → X(2)Π(v = 1) and the A(2)Σ(+) (v = 0) → X(2)Π(v = 0) bands...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28445486/a-metamodel-for-mobile-forensics-investigation-domain
#4
Abdulalem Ali, Shukor Abd Razak, Siti Hajar Othman, Arafat Mohammed, Faisal Saeed
With the rapid development of technology, mobile phones have become an essential tool in terms of crime fighting and criminal investigation. However, many mobile forensics investigators face difficulties with the investigation process in their domain. These difficulties are due to the heavy reliance of the forensics field on knowledge which, although a valuable resource, is scattered and widely dispersed. The wide dispersion of mobile forensics knowledge not only makes investigation difficult for new investigators, resulting in substantial waste of time, but also leads to ambiguity in the concepts and terminologies of the mobile forensics domain...
2017: PloS One
https://www.readbyqxmd.com/read/28444867/urine-assay-for-tenofovir-to-monitor-adherence-in-real-time-to-tenofovir-disoproxil-fumarate-emtricitabine-as-pre-exposure-prophylaxis
#5
H C Koenig, K Mounzer, G W Daughtridge, C E Sloan, L Lalley-Chareczko, G S Moorthy, S C Conyngham, A F Zuppa, L J Montaner, P Tebas
OBJECTIVES: Tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) is approved for pre-exposure prophylaxis (PrEP) against HIV infection. Adherence is critical for the success of PrEP, but current adherence measurements are inadequate for real-time adherence monitoring. We developed and validated a urine assay to measure tenofovir (TFV) to objectively monitor adherence to PrEP. METHODS: We developed a urine assay using high-performance liquid chromatography coupled to tandem mass spectrometry with high sensitivity/specificity for TFV that allowed us to determine TFV concentrations in log10 categories between 0 and 10 000 ng/mL...
April 26, 2017: HIV Medicine
https://www.readbyqxmd.com/read/28436849/reverse-classification-accuracy-predicting-segmentation-performance-in-the-absence-of-ground-truth
#6
Vanya V Valindria, Ioannis Lavdas, Wenjia Bai, Konstantinos Kamnitsas, Eric O Aboagye, Andrea G Rockall, Daniel Rueckert, Ben Glocker
When integrating computational tools such as automatic segmentation into clinical practice, it is of utmost importance to be able to assess the level of accuracy on new data, and in particular, to detect when an automatic method fails. However, this is difficult to achieve due to absence of ground truth. Segmentation accuracy on clinical data might be different from what is found through cross-validation because validation data is often used during incremental method development, which can lead to overfitting and unrealistic performance expectations...
April 17, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28434711/validation-of-an-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-method-to-quantify-illicit-drug-and-pharmaceutical-residues-in-wastewater-using-accuracy-profile-approach
#7
Cécile Hubert, Martin Roosen, Yves Levi, Sara Karolak
The analysis of biomarkers in wastewater has become a common approach to assess community behavior. This method is an interesting way to estimate illicit drug consumption in a given population: by using a back calculation method, it is therefore possible to quantify the amount of a specific drug used in a community and to assess the consumption variation at different times and locations. Such a method needs reliable analytical data since the determination of a concentration in the ngL(-1) range in a complex matrix is difficult and not easily reproducible...
April 15, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28432941/validation-of-a-spe-hplc-uv-method-for-the-quantification-of-a-new-er-specific-photosensitizer-or-141-in-blood-serum-using-total-error-concept
#8
Emilie Bony, Yohan Mace, Adán Pinto, David Delvaux, Robert Kiss, Olivier Riant, Olivier Feron, Joëlle Quetin-Leclercq
The aim of this work is to develop the first validated HPLC-UV method quantification in blood serum for a new endoplasmic reticulum (ER)-specific benzophenazine photosensitizer (OR-141). A fast solid phase extraction (SPE) cleaning sample procedure was achieved on C18 encapped (ec) SPE cartridges and the separation was performed on a RP-18e column (5μM) using an isocratic elution with methanol. The method has been fully validated according to accuracy profiles based on total error and tolerance intervals. Calibration was performed in the matrix and trueness (<4...
April 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28425890/biomedical-simulation-evolution-concepts-challenges-and-future-trends
#9
Carla Sá-Couto, Luís Patrão, Francisco Maio-Matos, José Miguel Pêgo
Biomedical simulation is an effective educational complement for healthcare training, both at undergraduate and postgraduate level. It enables knowledge, skills and attitudes to be acquired in a safe, educationally orientated and efficient manner. In this context, simulation provides skills and experience that facilitate the transfer of cognitive, psychomotor and proper communication competences, thus changing behavior and attitudes, and ultimately improving patient safety. Beyond the impact on individual and team performance, simulation provides an opportunity to study organizational failures and improve system performance...
December 30, 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28422306/development-of-a-novel-frailty-index-to-predict-mortality-in-patients-with-end-stage-liver-disease
#10
Jennifer C Lai, Kenneth E Covinsky, Jennifer L Dodge, W John Boscardin, Dorry L Segev, John P Roberts, Sandy Feng
BACKGROUND: Cirrhosis is characterized by muscle wasting, malnutrition, and functional decline that confer excess mortality not well quantified by the MELDNa score. We aimed to develop a frailty index to capture these extrahepatic complications of cirrhosis and enhance mortality prediction in cirrhotics. METHODS: Consecutive outpatients listed for LT at a single transplant center without MELD exceptions were assessed with candidate frailty measures. Best subset selection analyses with Cox regression identified subsets of frailty measures that predicted waitlist mortality (=death or delisting due to sickness)...
April 19, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28410112/epithelium-stroma-classification-via-convolutional-neural-networks-and-unsupervised-domain-adaptation-in-histopathological-images
#11
Yue Huang, Han Zheng, Chi Liu, Xinghao Ding, Gustavo Rohde
Epithelium-stroma classification is a necessary preprocessing step in histopathological image analysis. Current deep learning based recognition methods for histology data require collection of large volumes of labeled data in order to train a new neural network when there are changes to the image acquisition procedure. However, it is extremely expensive for pathologists to manually label sufficient volumes of data for each pathology study in a professional manner, which results in limitations in real-world applications...
April 6, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28407305/female-striated-urogenital-sphincter-contraction-measured-by-shear-wave-elastography-during-pelvic-floor-muscle-activation-proof-of-concept-and-validation
#12
Rafeef Aljuraifani, Ryan E Stafford, François Hug, Paul W Hodges
AIMS: Investigation of the function of the striated urogenital sphincter (SUS) is challenging because it is difficult to access and requires invasive measures. Ultrasound shear wave elastography (SWE) is a non-invasive real-time technique used to estimate tissue stiffness. As muscle stiffness can be used as an estimate of muscle force, SWE provides an opportunity to study contraction of the peri-urethral musculature. Validation of SWE to study SUS during functional tasks, such as pelvic floor muscle contractions, is required prior to application in clinical populations...
April 13, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28406459/homesound-real-time-audio-event-detection-based-on-high-performance-computing-for-behaviour-and-surveillance-remote-monitoring
#13
Rosa Ma Alsina-Pagès, Joan Navarro, Francesc Alías, Marcos Hervás
The consistent growth in human life expectancy during the recent years has driven governments and private organizations to increase the efforts in caring for the eldest segment of the population. These institutions have built hospitals and retirement homes that have been rapidly overfilled, making their associated maintenance and operating costs prohibitive. The latest advances in technology and communications envisage new ways to monitor those people with special needs at their own home, increasing their quality of life in a cost-affordable way...
April 13, 2017: Sensors
https://www.readbyqxmd.com/read/28406367/issue-relevant-values-and-opinions-about-gay-rights-beyond-equality-and-morality
#14
Laurie Rhodebeck
Although many studies have examined the role of values in shaping public opinion, the number of values that inform this research is limited. This paper employs the concept "issue-relevant values" as a means to explore the broader range of values associated with policy issues. After discussing the concept in general terms, the paper explores issue-relevant values pertinent to public opinion about gay rights. Using the policy examples of employment nondiscrimination and same-sex couple adoption, the present study identifies, measures, and assesses several values that add to the very short list previously used to explain public opinion about gay rights issues...
April 13, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28401478/improved-detection-of-norovirus-and-hepatitis-a-virus-in-surface-water-by-applying-pre-pcr-processing
#15
Emmy Borgmästars, Mehrdad Mousavi Jazi, Sofia Persson, Linda Jansson, Peter Rådström, Magnus Simonsson, Johannes Hedman, Ronnie Eriksson
Quantitative reverse transcriptase polymerase chain reaction (RT-qPCR) detection of waterborne RNA viruses generally requires concentration of large water volumes due to low virus levels. A common approach is to use dead-end ultrafiltration followed by precipitation with polyethylene glycol. However, this procedure often leads to the co-concentration of PCR inhibitors that impairs the limit of detection and causes false-negative results. Here, we applied the concept of pre-PCR processing to optimize RT-qPCR detection of norovirus genogroup I (GI), genogroup II (GII), and hepatitis A virus (HAV) in challenging water matrices...
April 11, 2017: Food and Environmental Virology
https://www.readbyqxmd.com/read/28401399/intelligent-viewpoint-selection-for-efficient-ct-to-video-registration-in-laparoscopic-liver-surgery
#16
Maria R Robu, Philip Edwards, João Ramalhinho, Stephen Thompson, Brian Davidson, David Hawkes, Danail Stoyanov, Matthew J Clarkson
PURPOSE: Minimally invasive surgery offers advantages over open surgery due to a shorter recovery time, less pain and trauma for the patient. However, inherent challenges such as lack of tactile feedback and difficulty in controlling bleeding lower the percentage of suitable cases. Augmented reality can show a better visualisation of sub-surface structures and tumour locations by fusing pre-operative CT data with real-time laparoscopic video. Such augmented reality visualisation requires a fast and robust video to CT registration that minimises interruption to the surgical procedure...
April 11, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28400312/assigning-clinical-codes-with-data-driven-concept-representation-on-dutch-clinical-free-text
#17
Elyne Scheurwegs, Kim Luyckx, Léon Luyten, Bart Goethals, Walter Daelemans
Clinical codes are used for public reporting purposes, are fundamental to determining public financing for hospitals, and form the basis for reimbursement claims to insurance providers. They are assigned to a patient stay to reflect the diagnosis and performed procedures during that stay. This paper aims to enrich algorithms for automated clinical coding by taking a data-driven approach and by using unsupervised and semi-supervised techniques for the extraction of multi-word expressions that convey a generalisable medical meaning (referred to as concepts)...
April 8, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28399565/conducting-privacy-preserving-multivariable-propensity-score-analysis-when-patient-covariate-information-is-stored-in-separate-locations
#18
Justin Bohn, Wesley Eddings, Sebastian Schneeweiss
Distributed networks of health-care data sources are increasingly being utilized to conduct pharmacoepidemiologic database studies. Such networks may contain data that are not physically pooled but instead are distributed horizontally (separate patients within each data source) or vertically (separate measures within each data source) in order to preserve patient privacy. While multivariable methods for the analysis of horizontally distributed data are frequently employed, few practical approaches have been put forth to deal with vertically distributed health-care databases...
March 15, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28386100/petri-net-computational-modelling-of-langerhans-cell-interferon-regulatory-factor-network-predicts-their-role-in-t-cell-activation
#19
Marta E Polak, Chuin Ying Ung, Joanna Masapust, Tom C Freeman, Michael R Ardern-Jones
Langerhans cells (LCs) are able to orchestrate adaptive immune responses in the skin by interpreting the microenvironmental context in which they encounter foreign substances, but the regulatory basis for this has not been established. Utilising systems immunology approaches combining in silico modelling of a reconstructed gene regulatory network (GRN) with in vitro validation of the predictions, we sought to determine the mechanisms of regulation of immune responses in human primary LCs. The key role of Interferon regulatory factors (IRFs) as controllers of the human Langerhans cell response to epidermal cytokines was revealed by whole transcriptome analysis...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28380001/changes-in-circulating-microrna-levels-can-be-identified-as-early-as-day-8-of-pregnancy-in-cattle
#20
Jason Ioannidis, F Xavier Donadeu
Poor reproductive performance remains a major issue in the dairy industry, with low conception rates having a significant impact on milk production through extended calving intervals. A major limiting factor is the lack of reliable methods for early pregnancy diagnosis. Identification of animals within a herd that fail to conceive within 3 weeks after insemination would allow early re-insemination and shorten calving intervals. In a previous study, we found an increase in plasma miR-26a levels in Day 16-pregnant relative to non-pregnant heifers, however changes in miRNA levels that early during pregnancy were very small which likely prevented the identification of robust biomarkers...
2017: PloS One
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