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https://www.readbyqxmd.com/read/29779295/neck-pain-what-if-it-is-not-musculoskeletal
#1
Nirosen Vijiaratnam, David R Williams, Kelly L Bertram
BACKGROUND: Neck pain is a common presentation in general practice, with muscle strain or osteoarthritis the most common diagnoses. A systematic approach for identifying red flags for alternative causes is required to appropriately investigate or refer for specialist opinion. OBJECTIVE: The aim of this article is to highlight features of neurological and other causes of neck pain in adults that may present in general practice, and to outline a quick and practical diagnostic approach...
May 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29777584/neuropsychiatric-expression-and-catatonia-in-22q11-2-deletion-syndrome-an-overview-and-case-series
#2
Nancy J Butcher, Erik Boot, Anthony E Lang, Danielle Andrade, Jacob Vorstman, Donna McDonald-McGinn, Anne S Bassett
Individuals with 22q11.2 deletion syndrome (22q11.2DS) are at elevated risk of developing treatable psychiatric and neurological disorders, including anxiety disorders, schizophrenia, seizures, and movement disorders, often beginning in adolescence or early to mid-adulthood. Here, we provide an overview of neuropsychiatric features associated with 22q11.2DS in adulthood. Results of a new case series of 13 individuals with 22q11.2DS and catatonic features together with 5 previously reported cases support a potential association of this serious psychomotor phenotype with the 22q11...
May 19, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29775977/-rehabilitation-after-traumatic-fracture-of-thoracic-and-lumbar-spine
#3
Hartmut Bork, Stefan Simmel, Eckhardt Böhle, Ulrich Ernst, Klaus Fischer, Bernd Fromm, Jean-Jacques Glaesener, Bernhard Greitemann, P Krause, S Panning, V Pullwitt, J Schmidt, Andreas Veihelmann, Lutz Vogt
On the basis of the S2-k guideline "Rehabilitation after traumatic fractures of the thoracic und lumbar spine without neurologic disorder", this article gives an overview of target-oriented rehabilitation of patients with minor fractures or those with column stability and unstable spinal fractures which are stabilised by surgery. To obtain early social and job related reintegration, outpatient or inpatient rehabilitation has to start immediately after treatment in hospital. Rehabilitation must be orientated towards the biopsychosocial model of ICF and has to be adapted for the patient...
May 18, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29775468/conflicts-of-interest-of-editors-of-medical-journals
#4
Waqas Haque, Abu Minhajuddin, Arjun Gupta, Deepak Agrawal
BACKGROUND: Almost all medical journals now require authors to publicly disclose conflicts of interests (COI). The same standard and scrutiny is rarely employed for the editors of the journals although COI may affect editorial decisions. METHODS: We conducted a retrospective observational study to determine the prevalence and magnitude of financial relationships among editors of 60 influential US medical journals (10 each for internal medicine and five subspecialties: cardiology, gastroenterology, neurology, dermatology and allergy & immunology)...
2018: PloS One
https://www.readbyqxmd.com/read/29774058/the-role-of-dopaminergic-immune-cell-signalling-in-poststroke-inflammation
#5
REVIEW
Daniela Talhada, Monika Rabenstein, Karsten Ruscher
Upon ischaemic stroke, brain-resident and peripheral immune cells accumulate in the central nervous system (CNS). Interestingly, these cells express pattern specific to neurotransmitter receptors and, therefore, seem to be susceptible to neurotransmitter stimulation, potentially modulating their properties and functions. One of the principal neurotransmitters in the CNS, dopamine, is involved in the regulation of processes of brain development, motor control and higher brain functions. It is constantly released in the brain and there is experimental and clinical evidence that dopaminergic signalling is involved in recovery of lost neurological function after stroke...
2018: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/29773308/collaboration-between-hospital-and-community-pharmacists-to-address-drug-related-problems-the-homecome-program
#6
Hendrik T Ensing, Ellen S Koster, Dasha J Dubero, Ad A van Dooren, Marcel L Bouvy
BACKGROUND: Hospital discharge poses a significant threat to the continuity of medication therapy and frequently results in drug-related problems post-discharge. Therefore, establishing continuity of care by realizing optimal collaboration between hospital and community pharmacists is of utmost importance. OBJECTIVE: To evaluate the collaboration between hospital and community pharmacists on addressing drug-related problems after hospital discharge. METHODS: A prospective follow-up study was conducted between November 2013-December 2014 in a general hospital and all affiliated community pharmacies...
May 8, 2018: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29772467/yawning-and-cortisol-levels-in-multiple-sclerosis-potential-new-diagnostic-tool
#7
Simon B N Thompson, Alister Coleman, Nicola Williams
Yawning is a significant behavioural response and, together with cortisol, is potentially a new diagnostic marker of neurological diseases. Evidence of an association between yawning and cortisol was found which supports the Thompson Cortisol Hypothesis and thermoregulation hypotheses, indication that brain cooling occurs when yawning. 117 volunteers aged 18-69 years were randomly allocated to experimentally controlled conditions to provoke yawning. Thirty-three had been diagnosed with multiple sclerosis. Saliva cortisol samples were collected before and after yawning or after stimuli presentation in the absence of yawning...
May 2, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29772219/differential-roles-of-polar-orbital-prefrontal-cortex-and-parietal-lobes-in-logical-reasoning-with-neutral-and-negative-emotional-content
#8
Iveta Eimontaite, Vinod Goel, Vanessa Raymont, Frank Krueger, Igor Schindler, Jordan Grafman
To answer the question of how brain pathology affects reasoning about negative emotional content, we administered a disjunctive logical reasoning task involving arguments with neutral content (e.g. Either there are tigers or women in NYC, but not both; There are no tigers in NYC; There are women in NYC) and emotionally laden content (e.g. Either there are pedophiles or politicians in Texas, but not both; There are politicians in Texas; There are no pedophiles in Texas) to 92 neurological patients with focal lesions to various parts of the brain...
May 14, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29771891/-leber-hereditary-optic-neuropathy
#9
I O Mazunin, N V Volodko
Leber hereditary optic neuropathy is characterized by bilateral, painless loss of vision in children and young adults (generally up to 25 years old). Since its first description in 1871, the understanding of its etiology and pathogenesis has improved considerably. The article considers Leber neuropathy from the points of view of ophthalmology, neurology and molecular genetics, and presents data on experimental treatment methods, one of which is undergoing clinical trial.
2018: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29771155/cardiac-events-within-one-year-after-a-subarachnoid-haemorrhage-the-predictive-value-of-troponin-elevation-after-aneurysm-occlusion
#10
Annemarie Akkermans, Linda M Peelen, Judith A van Waes, Gabriël J Rinkel, Wilton A van Klei
Background Patients who survive after an aneurysmal subarachnoid haemorrhage (ASAH) have an increased incidence of cardiovascular events compared with the general population. We assessed whether troponin elevation after aneurysm occlusion, as marker of myocardial injury, can predict long-term cardiac events. Methods We analysed a prospectively collected cohort of 159 patients with ASAH and early aneurysm occlusion, in whom routine post-intervention troponin I (TnI) measurements were performed. With competing risk regression modelling we estimated the association between TnI elevation after aneurysm occlusion and major adverse cardiac events within one year...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29770224/hybrid-surgery-radiosurgery-therapy-for-metastatic-epidural-spinal-cord-compression-a-prospective-evaluation-using-patient-reported-outcomes
#11
Ori Barzilai, Mary-Kate Amato, Lily McLaughlin, Anne S Reiner, Shahiba Q Ogilvie, Eric Lis, Yoshiya Yamada, Mark H Bilsky, Ilya Laufer
Background: Patient-reported outcomes (PRO) represent an important measure of cancer therapy effect. For patients with metastatic epidural spinal cord compression (MESCC), hybrid therapy using separation surgery and stereotactic radiosurgery preserves neurologic function and provides tumor control. There is currently a paucity of data reporting PRO after such combined modality therapy for MESCC. Delineation of hybrid surgery-radiosurgery therapy effect on PRO validates the hybrid approach as an effective therapy resulting in meaningful symptom relief...
May 2018: Neuro-oncology Practice
https://www.readbyqxmd.com/read/29769483/association-between-serum-apolipoprotein-b-and-acute-ischaemic-stroke
#12
M S Islam, M J Uddin, M Bhattacharjee, M N Farzana, R K Talukder, M A Rahman, M Mohsin, M A Rouf, H Pandit, M R Karim, R Ara, S Akhter, G Saha, M Oliullah, M S Ali, R Parveen
Stroke is one of the leading causes of death and disability in developed as well as developing countries like Bangladesh. There is a crucial need to identify additional risk factors that are easily measurable and treatable in general population. Role of serum lipids, lipoproteins and lipoprotein related variables in the prediction of stroke is less clear. Abnormalities in plasma lipoproteins are the most firmly established and best understood risk factors for atherosclerosis and they are probable risk factors for ischaemic stroke, largely by their link to atherosclerosis...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29766459/cognitive-functioning-in-chiari-malformation-type-i-without-posterior-fossa-surgery
#13
Maitane García, Esther Lázaro, Juan Francisco López-Paz, Oscar Martínez, Manuel Pérez, Sarah Berrocoso, Mohammad Al-Rashaida, Imanol Amayra
Chiari Malformation type I (CM-I) is a neurological disorder characterized by a displacement of the cerebellar tonsils through the foramen magnum into the spinal canal. Most research has focused on physical symptomatology but few studies include neuropsychological examinations. Moreover, although current research highlights the involvement of the cerebellum on higher cognitive functions, little is known about cognitive consequences associated with CM-I. The aim of this study is to analyze cognitive functioning between 39 CM-I patients and 39 healthy controls, matched by gender, age and years of education...
May 15, 2018: Cerebellum
https://www.readbyqxmd.com/read/29766384/increased-functional-meg-connectivity-as-a-hallmark-of-mri-negative-focal-and-generalized-epilepsy
#14
Yiwen Li Hegner, Justus Marquetand, Adham Elshahabi, Silke Klamer, Holger Lerche, Christoph Braun, Niels K Focke
Epilepsy is one of the most prevalent neurological diseases with a high morbidity. Accumulating evidence has shown that epilepsy is an archetypical neural network disorder. Here we developed a non-invasive cortical functional connectivity analysis based on magnetoencephalography (MEG) to assess commonalities and differences in the network phenotype in different epilepsy syndromes (non-lesional/cryptogenic focal and idiopathic/genetic generalized epilepsy). Thirty-seven epilepsy patients with normal structural brain anatomy underwent a 30-min resting state MEG measurement with eyes closed...
May 15, 2018: Brain Topography
https://www.readbyqxmd.com/read/29766029/seizure-suppressant-and-neuroprotective-effects-of-encapsulated-bdnf-producing-cells-in-a-rat-model-of-temporal-lobe-epilepsy
#15
Chiara Falcicchia, Giovanna Paolone, Dwaine F Emerich, Francesca Lovisari, William J Bell, Tracie Fradet, Lars U Wahlberg, Michele Simonato
Brain-derived neurotrophic factor (BDNF) may represent a therapeutic for chronic epilepsy, but evaluating its potential is complicated by difficulties in its delivery to the brain. Here, we describe the effects on epileptic seizures of encapsulated cell biodelivery (ECB) devices filled with genetically modified human cells engineered to release BDNF. These devices, implanted into the hippocampus of pilocarpine-treated rats, highly decreased the frequency of spontaneous seizures by more than 80%. These benefits were associated with improved cognitive performance, as epileptic rats treated with BDNF performed significantly better on a novel object recognition test...
June 15, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29764998/mapping-cortical-brain-asymmetry-in-17-141-healthy-individuals-worldwide-via-the-enigma-consortium
#16
Xiang-Zhen Kong, Samuel R Mathias, Tulio Guadalupe, David C Glahn, Barbara Franke, Fabrice Crivello, Nathalie Tzourio-Mazoyer, Simon E Fisher, Paul M Thompson, Clyde Francks
Hemispheric asymmetry is a cardinal feature of human brain organization. Altered brain asymmetry has also been linked to some cognitive and neuropsychiatric disorders. Here, the ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium presents the largest-ever analysis of cerebral cortical asymmetry and its variability across individuals. Cortical thickness and surface area were assessed in MRI scans of 17,141 healthy individuals from 99 datasets worldwide. Results revealed widespread asymmetries at both hemispheric and regional levels, with a generally thicker cortex but smaller surface area in the left hemisphere relative to the right...
May 15, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29764435/use-of-hospital-palliative-care-according-to-the-place-of-death-and-disease-one-year-before-death-in-2013-a-french-national-observational-study
#17
Claire Poulalhon, Laureen Rotelli-Bihet, Sébastien Moine, Anne Fagot-Campagna, Régis Aubry, Philippe Tuppin
BACKGROUND: Only limited data are available concerning the diseases managed before death and hospital palliative care (HPC) use according to place of death in France. We therefore conducted an observational study based on administrative health data in a large population to identify the diseases treated one year before death in 2013, the place of stay with or without hospital palliative care, and the place of death. METHODS: French health insurance general scheme beneficiaries were identified in the National Health data Information System (Snds) with a selection of information...
May 16, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29763712/cerebral-tissue-oximetry-levels-during-prehospital-management-of-cardiac-arrest-a-prospective-observational-study
#18
Gregor Prosen, Strnad Matej, Stephanie J Doniger, Andrej Markota, Andraž Stožer, Vesna Borovnik-Lesjak, Dušan Mekiš
INTRODUCTION: Near-infrared spectroscopy (NIRS) enables continuous monitoring of regional oximetry (rSO2 ). The aim of this study was to describe dynamics of regional cerebral oximetry levels during out of hospital cardiac arrest (OHCA) resuscitation, specifically around the time of restoration of spontaneous circulation (ROSC). METHODS: This prospective observational study was performed in the prehospital setting during cardio-pulmonary resuscitation (CPR) of OHCA patients...
May 12, 2018: Resuscitation
https://www.readbyqxmd.com/read/29763271/adults-with-developmental-disabilities-a-comprehensive-approach-to-medical-care
#19
Clarissa Kripke
Developmental disabilities are attributable to a cognitive impairment, physical impairment, or both. They manifest during the developmental period from birth to early adulthood, and are likely to continue indefinitely. The life expectancy of most persons with developmental disabilities now approaches that of the general population. According to the neurodiversity model of care, developmental disability is accepted as a valued part of human neurologic diversity. The social model focuses on improving participation in society with accommodations such as adaptive equipment or improvements to the social and physical environment...
May 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29760676/helsinki-stroke-model-is-transferrable-with-real-world-resources-and-reduced-stroke-thrombolysis-delay-to-34-min-in-christchurch
#20
Teddy Y Wu, Erin Coleman, Sarah L Wright, Deborah F Mason, Jon Reimers, Roderick Duncan, Mary Griffiths, Michael Hurrell, David Dixon, James Weaver, Atte Meretoja, John N Fink
Background: Christchurch hospital is a tertiary hospital in New Zealand supported by five general neurologists with after-hours services provided mainly by onsite non-neurology medical residents. We assessed the transferrability and impact of the Helsinki Stroke model on stroke thrombolysis door-to-needle time (DNT) in Christchurch hospital. Methods: Key components of the Helsinki Stroke model were implemented first in 2015 with introduction of patient pre-notification and thrombolysis by the computed tomography (CT) suite, followed by implementation of direct transfer to CT on ambulance stretcher in May 2017...
2018: Frontiers in Neurology
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