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https://www.readbyqxmd.com/read/29897831/zika-virus-vaccines-and-antiviral-strategies
#1
Sophie Masmejan, David Baud, Didier Musso, Alice Panchaud
Zika virus (ZIKV) recently emerged as a global public health emergency of international concern. ZIKV is responsible for severe neurological complications in adults and infection during pregnancy can lead to congenital Zika syndrome. There is no licensed vaccine or drug to prevent or treat ZIKV infection. Areas covered: The aim of this article is to provide an overview and update of the progress of research on anti-ZIKV vaccine and medications until the end of 2017, with a special emphasis on drugs that can be used during pregnancy...
June 13, 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29894448/neurologic-outcomes-after-extracorporeal-membrane-oxygenation-a-systematic-review
#2
Katharine Boyle, Ryan Felling, Alvin Yiu, Wejdan Battarjee, Jamie McElrath Schwartz, Cynthia Salorio, Melania M Bembea
OBJECTIVES: The goal of this systematic review of the literature was to summarize neurologic outcomes following neonatal and pediatric extracorporeal membrane oxygenation. DATA SOURCES: We conducted electronic searches of PubMed, Scopus, Web of Science, CINAHL, Cochrane, and EMBASE. STUDY SELECTION: Inclusion criteria included publication dates 2000-2016, patient ages 0-18 years, and use of standardized measures to evaluate outcomes after extracorporeal membrane oxygenation...
June 11, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29882695/vancouver-declaration-on-global-headache-patient-advocacy-2018
#3
David Dodick, Lars Edvinsson, Tomohiko Makino, Wolfgang Grisold, Fumihiko Sakai, Rigmor Jensen, Alan Balch, Elena Ruiz de la Torre, Deborah Henscheid-Lorenz, Audrey Craven, Messoud Ashina
Background Headache disorders comprise the three most prevalent medical disorders globally and contribute almost 20% to the total burden of neurologic illness. Although the experience of a recurrent headache disorder tends to be highly individualized, patient preferences tend to be a low priority in guidelines for the management of patients with headache. Methods In September 2017, the first Global Patient Advocacy Summit was convened, bringing together patients, patient advocates, patient advocacy organizations, healthcare professionals, pharmaceutical manufacturers, scientists, and regulatory agencies to advance issues of importance to patients affected by headache worldwide...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29876914/-social-and-familial-difficulties-as-a-consequence-of-the-neurological-illness-of-a-child-the-perspective-of-health-and-social-work
#4
A Gonzalez-Pena
When we speak of children with special needs, who require the aid of a number of professionals and who have a severe disability, it is necessary to have available a comprehensive group of different professionals (paediatrician, nurse, social worker, psychologist, etc.) who work together as a team. The specialist physician or doctor responsible for the sick child alone cannot take responsibility for all the psychosocial consequences that result from the neurological disease, which is a chronic illness that, generally speaking, means the families arrange their lives to revolve around the sick child...
June 5, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29865786/atrazine-triggers-mitochondrial-dysfunction-and-oxidative-stress-in-quail-coturnix-c-coturnix-cerebrum-via-activating-xenobiotic-sensing-nuclear-receptors-and-modulating-cytochrome-p450-systems
#5
Jia Lin, Hua-Shan Zhao, Xue-Nan Li, Lei Qin, Cong Zhang, Jun Xia, Jinlong Li
The residues from the widely used broad-spectrum environmental herbicide, atrazine (ATR) results in the exposure of non-target organisms and persisted as a global major public health hazard. ATR is neurotoxic and may cause adverse health effects in mammals, birds and fishes. Nevertheless, the molecular mechanism of ATR induced neurotoxicity is remains unclear. To assess the molecular mechanisms of ATR-induced cerebral toxicity through potential oxidative damage, quail were treated with ATR by oral gavage administration at doses of 0, 50, 250 and 500 mg/kg body weight daily for 45 days...
June 5, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29851280/review-article-environmental-heatstroke-and-long-term-clinical-neurological-outcomes-a-literature-review-of-case-reports-and-case-series-2000-2016
#6
REVIEW
Emily M Lawton, Helen Pearce, Genevieve M Gabb
Global temperatures are rising; extreme environmental heat can result in adverse health effects including heatstroke. Acute effects of heat are well recognised, but there is less understanding of potential long-term adverse outcomes. Our aim was to review recent medical literature for clinical cases of environmental heatstroke with a focus on neurological outcome. Structured search strategies were designed to retrieve publications of heatstroke case reports using Ovid Medline and Embase (2000-2016). One thousand and forty-nine abstracts were identified, and after application of exclusion criteria 71 articles deemed relevant...
May 31, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29806537/chikungunya-fever-a-threat-to-global-public-health
#7
Raíza Nara Cunha Moizéis, Thales Allyrio Araújo de Medeiros Fernandes, Paulo Marcos da Matta Guedes, Hannaly Wana Bezerra Pereira, Daniel Carlos Ferreira Lanza, Judson Welber Veríssimo de Azevedo, Josélio Maria de Araújo Galvão, José Veríssimo Fernandes
Chikungunya fever is an emerging arbovirus infection, representing a serious public health problem. Its etiological agent is the Chikungunya virus (CHIKV). Transmission of this virus is mainly vector by mosquitoes of the genus Aedes, although transmission by blood transfusions and vertical transmission has also been reported. The disease presents high morbidity caused mainly by the arthralgia and arthritis generated. Cardiovascular and neurological manifestations have also been reported. The severity of the infection seems to be directly associated with the action of the virus, but also with the decompensation of preexisting comorbidities...
May 28, 2018: Pathogens and Global Health
https://www.readbyqxmd.com/read/29803093/profiling-biomarkers-of-traumatic-axonal-injury-from-mouse-to-man
#8
REVIEW
Susruta Manivannan, Milan Makwana, Aminul Islam Ahmed, Malik Zaben
Traumatic brain injury (TBI) poses a major public health problem on a global scale. Its burden results from high mortality and significant morbidity in survivors. This stems, in part, from an ongoing inadequacy in diagnostic and prognostic indicators despite significant technological advances. Traumatic axonal injury (TAI) is a key driver of the ongoing pathological process following TBI, causing chronic neurological deficits and disability. The science underpinning biomarkers of TAI has been a subject of many reviews in recent literature...
May 18, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29802812/comorbid-fibromyalgia-a-qualitative-review-of-prevalence-and-importance
#9
REVIEW
Mary-Ann Fitzcharles, Serge Perrot, Winfried Häuser
BACKGROUND AND OBJECTIVE: Fibromyalgia (FM) may be an unrecognized cause of suffering for persons with an array of medical conditions. This is especially true for illness that is characterized by pain of any nature. Once believed to be a unique diagnosis, FM is recently reported to occur concomitantly with various rheumatic diseases, and importantly adversely impacts global health status. However there is increasing report of FM associated with other diseases that are not defined by chronic pain...
May 26, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29799906/chemotherapy-induced-peripheral-neuropathy-in-long-term-survivors-of-childhood-cancer-clinical-neurophysiological-functional-and-patient-reported-outcomes
#10
Tejaswi Kandula, Michelle Anne Farrar, Richard J Cohn, David Mizrahi, Kate Carey, Karen Johnston, Matthew C Kiernan, Arun V Krishnan, Susanna B Park
Importance: In light of the excellent long-term survival of childhood cancer patients, it is imperative to screen for factors affecting health, function, and quality of life in long-term survivors. Objective: To comprehensively assess chemotherapy-induced peripheral neuropathy in childhood cancer survivors to define disease burden and functional effect and to inform screening recommendations. Design, Setting, and Participants: In this cross-sectional observational study, cancer survivors who were treated with chemotherapy for extracranial malignancy before age 17 years were recruited consecutively between April 2015 and December 2016 from a single tertiary hospital-based comprehensive cancer survivorship clinic and compared with healthy age-matched controls...
May 14, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29791951/nervous-system-infections-and-the-global-traveler
#11
Savina Reid, Haley Thompson, Kiran T Thakur
Neurological complications of infectious diseases are associated with high rates of morbidity and mortality. It is imperative that neurologists be up-to-date on current developments including typical and atypical presentations of neurological infections in travelers, diagnostic and treatment recommendations, and emerging pathogen resistance patterns to avoid fatal outcomes and long-term sequelae. This article will address concepts of emerging and reemerging infectious diseases, and will provide updates on the neurological manifestations of select emerging and reemerging infections, including Ebola virus, bacterial meningitis, enterovirus 71, Zika virus, cerebral malaria, and Japanese encephalitis...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29791950/global-health-neurology-hiv-aids
#12
Payal B Patel, Serena S Spudich
With the advent of combination antiretroviral therapies, the mortality rate from HIV has declined, while the prevalence of long-term HIV-related neurologic complications continues to rise. Thirty-six million individuals are living with HIV around the world, many of whom reside in resource-limited settings. The majority of studies have focused on individuals residing in the developed world, while the impact of HIV disproportionately affects people living in developing countries. This review focuses on recent domestic and international studies regarding neurologic complications related to HIV, including opportunistic infections, peripheral neuropathy, cerebrovascular disease, and HIV-associated neurocognitive disorders, in light of the growing population affected by these conditions...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29791946/global-health-pediatric-neurology
#13
David R Bearden, Ornella Ciccone, Archana A Patel
Neurologic disorders contribute significantly to both morbidity and mortality among children in resource-limited settings, but there are a few succinct studies summarizing the epidemiology of neurologic disorders in these settings. A review of available literature was performed to identify data on the prevalence, etiology, outcomes, and treatment of neurologic disorders in children in resource-limited settings. The burden of neurologic disorders in children is high in resource-limited settings. Barriers to optimal care include lack of trained personnel, limited access to diagnostic technology, and limited availability of drugs used to treat common conditions...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29791943/the-growing-reality-of-the-neurological-complications-of-global-stem-cell-tourism
#14
Katie Julian, Nick Yuhasz, Ethan Hollingsworth, Jaime Imitola
"Stem cell tourism" is defined as the unethical practice of offering unproven cellular preparations to patients suffering from various medical conditions. This phenomenon is rising in the field of neurology as patients are requesting information and opportunities for treatment with stem cells for incurable conditions such as multiple sclerosis and amyotrophic lateral sclerosis, despite their clinical research and experimental designation. Here, we review the recent trends in "stem cell tourism" in both the United States and abroad, and discuss the recent reports of neurological complications from these activities...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29791942/emerging-viral-infections-and-their-impact-on-the-global-burden-of-neurological-disease
#15
Laura S Muñoz, Maria A Garcia, Eliza Gordon-Lipkin, Beatriz Parra, Carlos A Pardo
Emerging viral infections of the nervous system represent a major global public health concern in the 21st century. They are caused primarily by RNA viruses and are mostly associated with acute or subacute encephalitis. The spectrum of associated central or peripheral nervous system disorders is broad, and results either from a direct viral effect or due to the host immune responses against the infection. Emerging viral infections impose substantial neurological morbidity and mortality, particularly in low- and middle-income regions...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29791940/global-neurology-navigating-career-possibilities
#16
Nicoline Schiess, Deanna Saylor, Joseph Zunt
Neurology has not typically been associated with international relief work; however, with the growth of chronic cardiovascular disease and stroke associated with unhealthy eating and sedentary ways, the appearance of "new" neurologic diseases, such as the Zika and West Nile viruses, and the high numbers of seizure disorders resulting from neuroinfectious diseases, more opportunities are arising for international and globally oriented neurologists. Multiple opportunities exist for developing a global clinician-educator career pathway, including private institutions, nongovernmental organizations, government-funded opportunities such as Medical Education Partnership Initiative, Fogarty and Fulbright Scholarships, and the American Academy of Neurology's Global Health Section...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29770123/what-if-low-back-pain-is-the-most-prevalent-parkinsonism-in-the-world
#17
Jesse V Jacobs, Sharon M Henry, Fay B Horak
Low back pain (LBP) has a point prevalence of nearly 10% and ranks highest in global disease burden for years lived with disability; Parkinson's disease (PD) ranks in the top 100 most disabling health conditions for years lost and years lived with disability (1). Recent evidence suggests that people with chronic, recurrent LBP exhibit many postural impairments reminiscent of a neurological postural disorder such as PD. We compare and contrast postural impairments associated with LBP and PD in order to inform treatment strategies for both conditions...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29770095/zika-virus-where-to-from-here
#18
EDITORIAL
P K Muchaal
After the waves of reported cases of infection with Zika virus swept across the Americas in 2015-16, the overall transmission of the virus in the Western Hemisphere declined in 2017. Between June 8 and August 31, 2017, only 16 new cases of Zika virus infection, all travel-related, were reported in Canada. This represents an 88% reduction in the cases recorded during the same time frame in 2016. Herd immunity undoubtedly constrains the transmission of the virus in endemic regions. However, while most countries in the Americas are no longer observing continuous transmission in the form of sustained increases over time, some areas are experiencing a notable resurgence...
January 4, 2018: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29740383/nervous-system-injury-and-neuroimaging-of-zika-virus-infection
#19
REVIEW
Shanshan Wu, Yu Zeng, Alexander Lerner, Bo Gao, Meng Law
In 2016, World Health Organization announced Zika virus infection and its neurological sequalae are a public health emergency of global scope. Preliminary studies have confirmed a relationship between Zika virus infection and certain neurological disorders, including microcephaly and Guillain-Barre syndrome (GBS). The neuroimaging features of microcephaly secondary to Zika virus infection include calcifications at the junction of gray-white matter and subcortical white matter with associated cortical abnormalities, diminution of white matter, large ventricles with or without hydrocephalus, cortical malformations, hypoplasia of cerebellum and brainstem, and enlargement of cerebellomedullary cistern...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29724036/probing-molecular-insights-into-zika-virus%C3%A2-host-interactions
#20
REVIEW
Ina Lee, Sandra Bos, Ge Li, Shusheng Wang, Gilles Gadea, Philippe Desprès, Richard Y Zhao
The recent Zika virus (ZIKV) outbreak in the Americas surprised all of us because of its rapid spread and association with neurologic disorders including fetal microcephaly, brain and ocular anomalies, and Guillain⁻Barré syndrome. In response to this global health crisis, unprecedented and world-wide efforts are taking place to study the ZIKV-related human diseases. Much has been learned about this virus in the areas of epidemiology, genetic diversity, protein structures, and clinical manifestations, such as consequences of ZIKV infection on fetal brain development...
May 2, 2018: Viruses
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