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Xian Yang, Xue Zhang, Shui-Ping Yang, Tao Le, Bin Chen
Aucklandialappa Decne (ALD) is one of the traditional herbs to treat various kinds of disorders including asthma, cough, vomit, diarrhea, hepatitis and cholecystitis. However, its effects on indigestion and particularly antiulcer activity of ethanol extract have not been studied. In the study, the Aucklandia lappa Decne extract (ALDE) was investigated to see if it againstgastric injury effects through traditional pathways. Ethyl alcohol and epinephrine hydrochloride were used to induce acute gastric mucous membrane damage in adult SD rats and Kunming mice, respectively...
September 2016: Pakistan Journal of Pharmaceutical Sciences
Natamon Charakorn, Eric J Kezirian
Drug-induced sleep endoscopy (DISE) is an upper airway evaluation technique in which fiberoptic examination is performed under conditions of unconscious sedation. Unique information obtained from this 3-dimensional examination of the airway potentially provides additive benefits to other evaluation methods to guide treatment selection. This article presents recommendations regarding DISE technique and the VOTE Classification system for reporting DISE findings and reviews the evidence concerning DISE test characteristics and the association between DISE findings and treatment outcomes...
October 6, 2016: Otolaryngologic Clinics of North America
Soo Kweon Koo, Soon Bok Kwon, Yang Jae Kim, J I Seung Moon, Young Jun Kim, Sung Hoon Jung
Snoring is a sign of increased upper airway resistance and is the most common symptom suggestive of obstructive sleep apnea. Acoustic analysis of snoring sounds is a non-invasive diagnostic technique and may provide a screening test that can determine the location of obstruction sites. We recorded snoring sounds according to obstruction level, measured by DISE, using a smartphone and focused on the analysis of formant frequencies. The study group comprised 32 male patients (mean age 42.9 years). The spectrogram pattern, intensity (dB), fundamental frequencies (F 0), and formant frequencies (F 1, F 2, and F 3) of the snoring sounds were analyzed for each subject...
October 5, 2016: European Archives of Oto-rhino-laryngology
J L Peng, D G McDonald, J L Harper, M Ashenafi, M Fugal, C Mart, N C Koch, J G Dise, K N Vanek
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Sung Hoon Jung, Soo Kweon Koo, Jang Won Choi, Ji Seung Moon, Sang Hoon Lee
We studied upper airway structural changes induced by continuous positive airway pressure (CPAP) in obstructive sleep apnea syndrome (OSAS) patients using drug-induced sleep endoscopy (DISE). This prospective study was conducted at an academic secondary referral center. In total, 28 male OSAS patients (mean age 41.1 years) with only retropalatal level obstructions were enrolled. Measurements of the obstruction site were obtained in two steps: first a measurement was taken of the obstruction site in accordance with sleep apnea, then, a measurement was taken of the obstruction site in accordance with DISE-assisted CPAP titration, including quantitative changes in the occlusion site before and after CPAP in pixel format using an area calculation program...
July 29, 2016: European Archives of Oto-rhino-laryngology
Li-Ang Lee, Yu-Lun Lo, Jen-Fang Yu, Gui-She Lee, Yung-Lun Ni, Ning-Hung Chen, Tuan-Jen Fang, Chung-Guei Huang, Wen-Nuan Cheng, Hsueh-Yu Li
Snoring sounds generated by different vibrators of the upper airway may be useful indicators of obstruction sites in patients with obstructive sleep apnea hypopnea syndrome (OSAHS). This study aimed to investigate associations between snoring sounds, obstruction sites, and surgical responses (≥50% reduction in the apnea-hypopnea index [AHI] and <10 events/hour) in patients with OSAHS. This prospective cohort study recruited 36 OSAHS patients for 6-hour snoring sound recordings during in-lab full-night polysomnography, drug-induced sleep endoscopy (DISE), and relocation pharyngoplasty...
2016: Scientific Reports
Christopher Clark, Seckin O Ulualp
OBJECTIVES/HYPOTHESIS: Children with obstructive sleep apnea (OSA) may have multiple sites of upper airway obstruction (UAO). A wide variety of techniques has been used to evaluate UAO. Our aim was to compare findings of cine magnetic resonance imaging (MRI) and drug-induced sleep endoscopy (DISE) in identifying UAO sites in children with persistent OSA after adenotonsillectomy (AT). STUDY DESIGN: Retrospective chart review. MATERIAL AND METHODS: The medical records of children who underwent DISE and cine MRI were reviewed...
July 14, 2016: Laryngoscope
Yakup Yegïn, Mustafa Çelik, Kamïl Hakan Kaya, Arzu Karaman Koç, Fatma Tülin Kayhan
INTRODUCTION: Knowledge of the site of obstruction and the pattern of airway collapse is essential for determining correct surgical and medical management of patients with Obstructive Sleep Apnea Syndrome (OSAS). To this end, several diagnostic tests and procedures have been developed. OBJECTIVE: To determine whether drug-induced sleep endoscopy (DISE) or Müller's maneuver (MM) would be more successful at identifying the site of obstruction and the pattern of upper airway collapse in patients with OSAS...
June 20, 2016: Brazilian Journal of Otorhinolaryngology
Jack W Shteamer, Raj C Dedhia
OBJECTIVE: To examine the suitability of commonly used agents for drug-induced sleep endoscopy (DISE) based on agent-specific neuropharmacology. DATA SOURCES: PubMed. REVIEW METHODS: A literature search of the PubMed database was performed on January 1, 2016. A two-layered search strategy was performed to identify relevant pharmacologic agents and articles related to neuropharmacology for these agents. The first search identified relevant pharmacologic agents; the second search examined agents with greater than five results from search 1, along with medical subject headings "respiration," "sleep," "pharmacology," and/or "[respective agent] (e...
July 1, 2016: Laryngoscope
Trilochan Sahoo, Natasa Dzidic, Michelle N Strecker, Sara Commander, Mary K Travis, Charles Doherty, R Weslie Tyson, Arturo E Mendoza, Mary Stephenson, Craig A Dise, Carlos W Benito, Mandolin S Ziadie, Karine Hovanes
PURPOSE: Chromosomal microarray analysis (CMA) is currently considered first-tier testing in pediatric care and prenatal diagnosis owing to its high diagnostic sensitivity for chromosomal imbalances. The aim of this study was to determine the efficacy and diagnostic power of CMA in both fresh and formalin-fixed paraffin-embedded (FFPE) samples of products of conception (POCs). METHODS: Over a 44-month period, 8,118 consecutive samples were received by our laboratory for CMA analysis...
June 23, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Norman R Friedman, Sanjay R Parikh, Stacey L Ishman, Amanda G Ruiz, Hamdy El-Hakim, Seckin O Ulualp, Christopher T Wootten, Peter J Koltai, Dylan K Chan
OBJECTIVES/HYPOTHESIS: The purpose of this investigation was to assess current drug-induced sleep endoscopy (DISE) practice patterns at centers that have published on the technique, to identify areas of agreement, and to identify areas of disagreement that may represent opportunities for improvement and standardization. STUDY DESIGN: Multi-institutional survey. METHODS: A survey was designed in two phases to evaluate preoperative assessment, intraoperative performance, and postoperative management of patients undergoing DISE...
June 16, 2016: Laryngoscope
John P Dahl, Craig Miller, Patricia L Purcell, David A Zopf, Kaalan Johnson, David L Horn, Maida L Chen, Dylan K Chan, Sanjay R Parikh
OBJECTIVE: To determine if standardized intraoperative scoring of anatomic obstruction in children with obstructive sleep apnea correlates with the apnea-hypopnea index (AHI) and lowest oxygen saturation on preprocedural polysomnogram (PSG). A secondary objective was to determine if age, presence of a syndrome, or previous adenotonsillectomy affect this correlation. STUDY DESIGN: Case series with chart review. SETTING: Two tertiary care children's hospitals...
October 2016: Otolaryngology—Head and Neck Surgery
Nicolette Taku, Joseph Dise, Owen Kenton, Lingshu Yin, Boon-Keng Kevin Teo, Lilie L Lin
BACKGROUND AND PURPOSE: To quantify intra-treatment vaginal motion in women treated with daily endorectal balloon (ERB) placement and external beam radiotherapy for gynecologic cancers. MATERIALS AND METHODS: Eighteen post-hysterectomy women with gynecologic cancers underwent computed tomography (CT) simulation scans and daily treatment with ERB. Fiducial markers were placed at the vaginal apex prior to simulation and patients were counseled on a pre-treatment bladder filling protocol...
May 28, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Ali Kandil, Rajeev Subramanyam, Mohamed Monir Hossain, Stacey Ishman, Sally Shott, Anurag Tewari, Mohamed Mahmoud
AIM: Examination of dynamic airway collapse in patients with obstructive sleep apnea (OSA) during drug-induced sleep endoscopy (DISE) can help identify the anatomic causes of airway obstruction. We hypothesized that a combination of dexmedetomidine and ketamine (Group DK) would result in fewer oxygen desaturations and a higher successful completion rate during DISE in children with OSA when compared to propofol (Group P) or sevoflurane/propofol (Group SP). METHODS: In this retrospective study, we reviewed the records of 59 children who presented for DISE between October 2013 and March 2015...
July 2016: Paediatric Anaesthesia
Soo Kweon Koo, Gun Young Ahn, Jang Won Choi, Young Jun Kim, Sung Hoon Jung, Ji Seung Moon, Young Il Lee
INTRODUCTION: The key to successful treatment of OSAS is to individually tailor such treatment. Thus, it is very important to determine the severity of OSAS, its pattern, and the extent of collapse, by gender, age, and BMI. OBJECTIVE: The objective of the study was to understand the characteristics of obstructive sleep apnea in postmenopausal women by comparing postmenopausal and premenopausal subjects, and men, using DISE. We hope that our work will help the medical community to consult on, diagnose, and treat OSAS more effectively...
April 25, 2016: Brazilian Journal of Otorhinolaryngology
Alonço da Cunha Viana, Daniella Leitão Mendes, Lucas Neves de Andrade Lemes, Luiz Claudio Santos Thuler, Denise Duprat Neves, Maria Helena de Araújo-Melo
Obstructive sleep apnea (OSA) is characterized by recurrent episodes of partial or complete collapse of the pharynx that result in a decrease in oxyhemoglobin saturation. Nasofibrolaryngoscopy under induced sleep is a promising alternative for identifying sites of upper airway obstruction in patients with OSA. This study aimed to compare the obstruction sites screened by drug-induced sleep endoscopy (DISE) using the Nose oropharynx hypopharynx and larynx (NOHL) and Velum oropharynx tongue base epiglottis (VOTE) classifications...
May 10, 2016: European Archives of Oto-rhino-laryngology
Patrick Kellner, Beatrice Herzog, Sebastian Plößl, Christian Rohrmeier, Thomas Kühnel, Ramona Wanzek, Stefan Plontke, Michael Herzog
PURPOSE: Drug-induced sedation endoscopy (DISE) and simulated snoring (SimS) can locate the site of obstruction in patients with sleep-disordered breathing (SDB). There is clinical evidence for a change in collapsibility of the upper airway depending on the depth of sedation. So far, a dose-response relationship between sedation and collapsibility has not been demonstrated. METHODS: DISE and SimS were performed in 60 consecutive patients with SDB under monitoring of depth of sedation by BiSpectral Index® (BIS)...
September 2016: Sleep & Breathing, Schlaf & Atmung
Ming-Chin Lan, Yen-Bin Hsu, Ming-Ying Lan, Tsan-Jen Chiu, Tung-Tsun Huang, Shi-Bing Wong, Yu-Cheng Chen, Li-Ping Tsai
PURPOSE: Review drug-induced sleep endoscopy (DISE) findings in children with Prader-Willi syndrome (PWS) and correlate the patterns of airway collapse with apnea-hypopnea index (AHI) and body mass index (BMI). METHODS: A total of nine children with PWS underwent DISE. DISE findings were recorded using the VOTE classification system. The relationship between different patterns of airway collapse with AHI and BMI was analyzed. RESULTS: The majority of children with PWS were found to have multilevel obstruction (six out of nine children, 66...
September 2016: Sleep & Breathing, Schlaf & Atmung
Katherine A Connolly, Stephanie H Factor, Chloe S Getrajdman, Catherine A Bigelow, Andrea S Weintraub, Joanne L Stone
OBJECTIVE: Based on anecdotal observations, there is concern that severe preeclampsia leads to greater morbidity and mortality for mothers and neonates of twin pregnancies than for mothers and neonates of singleton pregnancies. Because few studies have been done, this study compared maternal disease characteristics and maternal/neonatal clinical outcomes of twin and singleton pregnancies complicated by severe preeclampsia. STUDY DESIGN: An historical cohort study of patients hospitalized at the Mount Sinai Hospital in New York City, NY, USA, from 2006 to 2010, compared 63 twin and 339 singleton pregnancies complicated by severe preeclampsia via chart review...
June 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Frank Schneider, Kristen L Veraldi, Marc C Levesque, Thomas V Colby, Eunhee S Yi
We report a case of immunoglobulin(Ig)G4-related disease with the radiologic and histopathological manifestations resembling usual interstitial pneumonia (UIP). The patient was a 62-year-old man who presented with progressive dyspnea of insidious onset. High resolution computed tomography of the chest showed lower-lobe predominant peripheral reticulation and traction bronchiectasis but no honeycomb change. Microscopic examination of the surgical lung biopsy showed characteristic features of UIP including architectural distortion by fibrosis with peripheral and paraseptal accentuation, scattered fibroblast foci and microscopic honeycomb change...
2016: Open Rheumatology Journal
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