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https://www.readbyqxmd.com/read/28550741/exploring-syndrome-differentiation-using-non-negative-matrix-factorization-and-cluster-analysis-in-patients-with-atopic-dermatitis
#1
Younghee Yun, Wonmo Jung, Hyunho Kim, Bo-Hyoung Jang, Min-Hee Kim, Jiseong Noh, Seong-Gyu Ko, Inhwa Choi
Syndrome differentiation (SD) results in a diagnostic conclusion based on a cluster of concurrent symptoms and signs, including pulse form and tongue color. In Korea, there is a strong interest in the standardization of Traditional Medicine (TM). In order to standardize TM treatment, standardization of SD should be given priority. The aim of this study was to explore the SD, or symptom clusters, of patients with atopic dermatitis (AD) using non-negative factorization methods and k-means clustering analysis...
May 22, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28545533/food-beliefs-and-practices-among-the-kalenjin-pregnant-women-in-rural-uasin-gishu-county-kenya
#2
Roselyter Monchari Riang'a, Jacqueline Broerse, Anne Kisaka Nangulu
BACKGROUND: Understanding food beliefs and practices is critical to the development of dietary recommendations, nutritional programmes, and educational messages. This study aimed to understand the pregnancy food beliefs and practices and the underlying reasons for these among the contemporary rural Kalenjin communities of Uasin Gishu County, Kenya. METHODS: Through semi-structured interviews, data was collected from 154 pregnant and post-natal Kalenjin women about restricted and recommended foods, and why they are restricted or recommended during pregnancy...
May 25, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28536750/transoral-robotic-excision-of-a-lingual-thyroglossal-duct-cyst
#3
Stephanie Fong, John-Charles Hodge, Andrew Foreman, Suren Krishnan
Lingual thyroglossal duct cysts are a rare and potentially difficult to manage tongue base lesion. We report a case of transoral robotic surgical excision of a lingual thyroglossal duct cyst, in an adult patient. A 68-year-old man presented with a large base of tongue mass, with appearance on ultrasound and computed tomography consistent with a lingual thyroglossal duct cyst. We describe the surgical technique for transoral robotic excision of the cyst. The cyst was completely excised, and the patient had a smooth recovery...
May 23, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28532609/risk-factors-for-osteonecrosis-of-the-jaw-in-oral-cancer-patients-after-surgery-and-eventual-adjuvant-treatment-the-potential-role-of-chemotherapy
#4
Tzu-Yu Lai, Ti-Hao Wang, Chia-Jen Liu, Tze-Fan Chao, Tzeng-Ji Chen, Yu-Wen Hu
BACKGROUND AND PURPOSE: To identify the risk factors for osteonecrosis of the jaw (ONJ) in oral cancer patients after surgery with and without adjuvant therapy in a nationwide, population-based study. MATERIAL AND METHODS: Using the Taiwan National Health Insurance Research Dataset, we recruited patients with newly diagnosed oral cancer between 1997 and 2011. All of them underwent primary surgery. Data regarding demographic characteristics; tooth extractions; medications; and cancer treatments, including types of mandibular surgery, radiotherapy and platinum-based chemotherapy, were collected for analysis...
May 19, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28532495/development-and-validation-of-the-angiotensin-converting-enzyme-inhibitor-acei-induced-angioedema-investigator-rating-scale-and-proposed-discharge-criteria
#5
Nicola Bonner, Charlotte Panter, Alan Kimura, Rich Sinert, Joseph Moellman, Jonathan A Bernstein
BACKGROUND: The use of angiotensin-converting enzyme inhibitors (ACEI) has been associated with the development of bradykinin-mediated angioedema. With ever-widening indications for ACEI in diseases including hypertension, congestive heart failure and diabetic nephropathy, a concomitant increase in ACEI-Angioedema (ACEI-A) has been reported. At present there is no validated severity scoring or discharge criteria for ACEI-A. We sought to develop and validate an investigator rating scale with corresponding discharge criteria using clinicians experienced in treating ACEI-A...
May 22, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28532411/aldehyde-dehydrogenase-2-2-knock-in-mice-show-increased-reactive-oxygen-species-production-in-response-to-cisplatin-treatment
#6
Jeewon Kim, Che-Hong Chen, Jieying Yang, Daria Mochly-Rosen
BACKGROUND: The aldehyde dehydrogenase (ALDH) enzyme family metabolizes and detoxifies both exogenous and endogenous aldehydes. Since chemotherapeutic agents, such as cisplatin, generate cytotoxic aldehydes and oxidative stress, and chemoresistant cancer cells express high levels of ALDH enzymes, we hypothesized that different ALDH expression within cells may show different chemosensitivity. ALDH2 has the lowest Km for acetaldehyde among ALDH isozymes and detoxifies acetaldehydes in addition to other reactive aldehydes, such as 4-hydroxy-nonenal, malondialdehyde and acrolein produced from lipid peroxidation by reactive oxygen species (ROS)...
May 22, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28529003/determination-of-the-appropriate-oropharyngeal-airway-size-in-adults-assessment-using-ventilation-and-an-endoscopic-view
#7
Hyun Joo Kim, Shin Hyung Kim, Ji Young Min, Wyun Kon Park
INTRODUCTION: Size 9 and 8 airways for men and women, respectively, have been proposed as most appropriate based on endoscopy. However, a limitation of this guideline is that ventilation was not assessed. METHODS: In this retrospective review of prospectively collected data, 149 patients requiring tracheal intubation for general anesthesia were included. The adequacy for manual and pressure-controlled mechanical ventilation and views at the distal end of each airway was assessed using a fiber-optic bronchoscope with various airway sizes (7, 8, 9, 10, and 11)...
April 14, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28528369/effect-of-physical-stress-on-drug-induced-sleep-endoscopy-for-obstructive-sleep-apnea
#8
Sang Min Park, Dong-Kyu Kim
Drug-induced sleep endoscopy (DISE) is a reliable upper airway evaluation tool, widely used to improve surgical results in patients with obstructive sleep apnea (OSA). Several factors, including sleeping position and depth of sedation, affect DISE findings. This study aimed to evaluate the impact of physical stress on DISE findings. Eighty-five patients with OSA underwent two DISE examinations at the same level of sedation. The "first DISE" (control group) was performed after polysomnography, while the "second DISE" (test group) performed immediately after a treadmill stress test...
May 20, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28526903/compartmental-tongue-resection-with-submental-island-flap-reconstruction-for-large-carcinoma-of-the-oral-tongue
#9
Sameh Roshdy, Mohamed Elbadrawy, Ashraf Khater, Tamer Fady, Hend A El-Hadaad, Nazem Shams, Hany M Elbarbary
BACKGROUND: Tongue resection is a surgical challenge because of its adverse effects on language articulation, swallowing, respiration, the eventual quality of life, and poor prognosis of advanced disease. To date, the currently accepted standard treatment has been based on excision of the primary lesion with a 1.5-2-cm circumferential macroscopic margin. Compartmental tongue surgery (CTS) is a surgical technique that removes an anatomo-functional compartment containing the primary tumor...
May 19, 2017: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28526655/digital-morphometrics-a-new-upper-airway-phenotyping-paradigm-in-obstructive-sleep-apnea
#10
Richard J Schwab, Sarah E Leinwand, Cary B Bearn, Greg Maislin, Ramya Bhat Rao, Adithya Nagaraja, Stephen Wang, Brendan T Keenan
BACKGROUND: Obstructive sleep apnea (OSA) is associated with changes in pharyngeal anatomy. The goal of this study was to objectively and reproducibly quantify pharyngeal anatomy using digital morphometrics based on a laser ruler, and to assess differences between apneics and controls and associations with AHI (apnea-hypopnea index). This is the first study to use digital morphometrics to quantify intraoral risk factors for OSA. METHODS: Digital photographs were obtained using an intraoral laser ruler and digital camera in 311 controls (mean AHI=4...
May 16, 2017: Chest
https://www.readbyqxmd.com/read/28525363/targeted-sequencing-of-tonsillar-and-base-of-tongue-cancer-and-human-papillomavirus-positive-unknown-primary-of-the-head-and-neck-reveals-prognostic-effects-of-mutated-fgfr3
#11
Cinzia Bersani, Lars Sivars, Linnea Haeggblom, Sebastian DiLorenzo, Michael Mints, Andreas Ährlund-Richter, Nikolaos Tertipis, Eva Munck-Wikland, Anders Näsman, Torbjörn Ramqvist, Tina Dalianis
BACKGROUND: Human papillomavirus positive (HPV+) tonsillar cancer (TSCC), base of tongue cancer (BOTSCC) and unknown primary cancer of the head and neck (HNCUP) have better outcome than corresponding HPV- cancers. To find predictive markers for response to treatment, and correlations and differences in mutated oncogenes and suppressor genes between HPV+ TSCC/BOTSSCC and HPV+ HNCUP and HPV- TSCC/BOTSCC targeted next-generation sequencing was performed of frequently mutated regions in 50 cancer related genes...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28523036/relationship-of-oral-tumor-thickness-with-the-rate-of-lymph-node-metastasis-in-neck-based-on-ct-scan
#12
Sohail Ahmed Khan, Sadaf Zia, Syeda Uzma Naqvi, Hatem Adel, Syed Omair Adil, Munawar Hussain
OBJECTIVE: To determine the relationship of tumor thickness of oral lesions with metastasis in neck based on CT scan. METHODS: A total of 58 oral squamous cell carcinoma patients having the median age of 46 (39-55) years. with either gender presented with malignant tumor of buccal mucosa and tongue were prospectively enrolled. A CT Scan with contrast was performed on all patients. Correlation of tumor thickness level with metastasis in neck was calculated using spearman's rank correlation coefficient test...
March 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28522150/implementation-of-a-wearable-ultrasound-device-for-the-overnight-monitoring-of-tongue-base-deformation-during-obstructive-sleep-apnea-events
#13
Chi-Kai Weng, Jeng-Wen Chen, Po-Yang Lee, Chih-Chung Huang
Obstructive sleep apnea (OSA) is a breathing disorder characterized by the repeated collapse of the pharyngeal airway during sleep. Previous studies have reported that tongue base deformation may be a major contributing factor. However, overnight monitoring of tongue motion in patients with OSA has previously been impracticable. We developed a wearable ultrasound device for prolonged recording during natural sleep of the changes in tongue base thickness (TBT) in patients with OSA. The maximum TBT was fed into a polysomnography system so that physiologic signals and TBT data were simultaneously monitored...
May 15, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28514726/retrospective-analysis-of-risk-factors-associated-with-kawasaki-disease-in-china
#14
Lihua Bai, Tienan Feng, Lifang Yang, Yi Zhang, Xuejuan Jiang, Jiayao Liao, Lihua Chen, Xiaoyan Feng, Yanming Rong, Yuehua Li, Zhiqiang Qin, Jing Qiao
In order to provide early intervention for coronary artery lesion (CAL) caused by Kawasaki Disease (KD), we analyzed clinical characteristics of typical and incomplete KD cases from 1998 to 2008 in Northwest and Central China. A total of 383 patients included 298 cases of typical KD and 85 cases of incomplete KD. The morbidity of incomplete KD was 28.5%, a percentage significantly lower than that of typical KD. The occurrence of bulbar conjunctiva congestion, erythra, crissum red, film-like decrustation, lip red, rhagades, raspberry tongue, bilateral toe-end decrustation, limb sclerosis, cervical lymph nodes enlargement, agitation and irritability in incomplete KD group was lower than that in the group of typical KD (p < 0...
April 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28504187/transoral-oropharyngeal-resection-classification-proposal-of-the-scorl-working-group
#15
David Virós Porcuna, Francisco Avilés Jurado, Carlos Pollán Guisasola, Rosa Delia Ramírez Ruiz, Jacinto García Lorenzo, Marc Tobed Secall, Isabel Vilaseca González, José Miguel Costa González, Josep Soteras Olle, Francesc Casamitjana Claramunt, Anna Sumarroca Trouboul, Rafael Hijano Esqué, Guillem Viscasillas Pallàs, Manel Mañós Pujol, Miquel Quer Agustí
INTRODUCTION AND GOALS: There has been a very significant increase in the use of minimally invasive surgery has in the last decade. In order to provide a common language after transoral surgery of the oropharynx, a system for classifying resections has been created in this area, regardless of the instrumentation used. METHODS: From the Oncology Working Group of the Catalan Society of Otorhinolaryngology, a proposal for classification based on a topographical division of the different areas of the oropharynx is presented, as also based on the invasion of the related structures according to the anatomical routes of extension of these tumours...
May 11, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28500875/upper-airway-changes-after-mandibular-setback-and-or-advancement-genioplasty-in-obese-patients
#16
Wen Du, Dongming He, Yiyao Wang, Hanghang Liu, Chuhang Liao, Wei Fei, En Luo
PURPOSE: Orthognathic surgeries, such as bilateral sagittal split ramus osteotomy (BSSO) and genioplasty, can influence the pharyngeal airway space (PAS) and this has been supported by previous studies. The purpose of this study was to assess changes of the PAS in patients with a high body mass index (BMI) likely to have narrow airways before and after setback BSSO with or without advancement genioplasty surgery by 3-dimensional computed tomography. MATERIALS AND METHODS: Thirty-five adults with a BMI of at least 24...
April 19, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28497558/ectopic-thyroid-mass-in-the-right-ventricle-a-case-report
#17
Yuying Tan, Wei Yu, Xiaocong Wang, Yongsheng Gao, Hui Xu
Ectopic thyroid is a rare congenital embryonic anomaly. Ectopic thyroid tissue can be located anywhere during its descent, but it is found primarily at the base of the tongue and in the mediastinum. It is very rarely found in the heart. Here, we report a rare case of cardiac ectopic thyroid tissue in a 53-year-old woman who presented with chest pain. Echocardiography revealed an intracardiac mass that was removed successfully. Histopathology confirmed that the mass was thyroid tissue without malignancy.
May 12, 2017: Echocardiography
https://www.readbyqxmd.com/read/28495272/pannexins-in-vision-hearing-olfaction-and-taste
#18
REVIEW
Paige Whyte-Fagundes, Ryan Siu, Cherie Brown, Georg Zoidl
In mammals, the pannexin gene family consists of three members (Panx1, 2, 3), which represent a class of integral membrane channel proteins sharing some structural features with chordate gap junction proteins, the connexins. Since their discovery in the early 21st century, pannexin expression has been detected throughout the vertebrate body including eye, ear, nose and tongue, making the investigation of the roles of this new class of channel protein in health and disease very appealing. The localization in sensory organs, coupled with unique channel properties and associations with major signaling pathways make Panx1, and its relative's, significant contributors for fundamental functions in sensory perception...
May 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28494172/an-investigation-of-clear-speech-effects-on-articulatory-kinematics-in-talkers-with-als
#19
Mili Kuruvilla-Dugdale, Miguel Chuquilin-Arista
Amyotrophic lateral sclerosis (ALS) affects the speech motor system and causes a substantial decline in intelligibility. Clear speech strategies have been found to benefit intelligibility in talkers with dysarthria and the purpose of this study was to examine clear speech effects on tongue, lip, and jaw movements in persons with ALS and healthy controls. For this purpose, participants produced 10 repetitions of the sentence 'I owe you a yoyo' using both habitual and clear speech. Movement variability as well as maximum speed, range, and duration of movement of the articulators were obtained for both conditions...
May 11, 2017: Clinical Linguistics & Phonetics
https://www.readbyqxmd.com/read/28493195/udise-model-a-universal-drug-induced-sedation-endoscopy-classification-system-part-1
#20
Esuabom Dijemeni, Gabriele D'Amone, Israel Gbati
Drug-induced sedation endoscopy (DISE) classification systems play a significant role in clinical analysis based on DISE findings, treatment decision process, treatment planning process and fundamentally in treatment outcomes. However, there is a major problem: there is no universally agreed DISE classification system. Hence, for the same DISE examination different DISE classification systems can be used to: assess anatomic findings, decide and plan different treatments. Hence, this leads to different treatment outcomes...
May 10, 2017: European Archives of Oto-rhino-laryngology
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