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https://www.readbyqxmd.com/read/27930761/transoral-robotic-surgery-assisted-endoscopy-with-primary-site-detection-and-treatment-in-occult-mucosal-primaries
#1
Kyle M Hatten, Bert W O'Malley, Andres M Bur, Mihir R Patel, Christopher H Rassekh, Jason G Newman, Steven B Cannady, Ara A Chalian, Benjamin L Hodnett, Alexander Lin, John N Lukens, Roger B Cohen, Joshua M Bauml, Kathleen T Montone, Virginia A Livolsi, Gregory S Weinstein
Importance: Management of cervical lymph node metastasis without a known primary tumor is a diagnostic and treatment challenge for head and neck oncologists. Identification of the occult mucosal primary tumor minimizes the morbidity of treatment. Objective: To analyze the role of transoral robotic surgery (TORS) in facilitating the identification of a primary tumor site for patients presenting with squamous cell carcinoma of unknown primary (CUP). In addition, we assessed treatment deintensification by determining the number of patients who did not undergo definitive radiation therapy and chemotherapy...
December 8, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27928446/gastrostomy-with-peritoneal-collar-versus-percutaneous-endoscopic-gastrostomy
#2
Tudor C, Branescu C, Savlovschi C, El-Khatib A, Pantu H, Nica A, Dascalu Am, Masoumeh B, Tudor As, Oprescu Sm, Serban D
Aim. The present study aimed to perform a medico-surgical comparative analysis of the 2 most widely used techniques: gastrostomy with peritoneal collar versus percutaneous endoscopic gastrostomy, based on the vast clinical experience in an Upper Digestive Surgery Clinic. Materials and method. A retrospective study was carried out between January 2010 and January 2015 on the patients admitted for a surgical solution for feeding. The indications, preoperative preparation, surgical techniques, and postoperative outcomes were analyzed...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27926796/novel-umami-ingredients-umami-peptides-and-their-taste
#3
REVIEW
Yin Zhang, Chandrasekar Venkitasamy, Zhongli Pan, Wenlong Liu, Liming Zhao
Umami substances are very important for food seasoning and healthy eating. In addition to monosodium glutamate and some nucleotides, recent investigations have revealed that several peptides also exhibit umami taste. In recent years, 52 peptides have been reported to show umami taste, including 24 dipeptides, 16 tripeptides, 5 octapeptides, 2 pentapeptides, 2 hexapeptides, 1 tetrapeptide, 1 heptapeptide, and 1 undecapeptide. Twenty of these peptides have been examined for the present of umami taste. In this review, we have listed these umami peptides based on their category, source, taste, and threshold concentration...
December 7, 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27926789/characterization-of-the-oropharynx-anatomy-histology-immunology-squamous-cell-carcinoma-surgical-resection
#4
REVIEW
Croix C Fossum, Ashish V Chintakuntlawar, L Price, Joaquin J Garcia
Understanding the structure and function of the oropharynx is paramount to providing excellent patient care. In clinical oncology, the oropharynx is generally divided into four distinct components: (1) base of tongue, (2) soft palate, (3) palatine tonsillar fossa, and (4) pharyngeal wall. Oropharyngeal mucosa is distinct from other mucosal surfaces in the body since it is comprised of a reticulated epithelium with a discontinuous basement membrane, also known as lymphoepithelium. This review article describes the anatomy, histology, immunology and surgical resection of the oropharynx as it relates to oncologic care...
December 7, 2016: Histopathology
https://www.readbyqxmd.com/read/27925687/dna-base-excision-repair-proteins-ape-1-and-xrcc-1-are-overexpressed-in-oral-tongue-squamous-cell-carcinoma
#5
Thalita Santana, Melka Coêlho Sá, Edilmar de Moura Santos, Hébel Cavalcanti Galvão, Ricardo D Coletta, Roseana de Almeida Freitas
BACKGROUND: DNA repair systems play a critical role in protecting the human genome from damage caused by carcinogens. Modifications in DNA repair genes may be responsible for tumor development and resistance of malignant cells to chemotherapeutic agents. The major pathway for oxidative DNA damage repair is the base excision repair pathway. This study aimed to assess the immunoexpression of DNA repair proteins APE-1 and XRCC-1 and its association with clinical, histological and survival parameters in oral tongue squamous cell carcinoma in order to investigate a possible role for those proteins in tumor behavior...
December 7, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27924294/data-for-a-pre-performance-test-of-self-developed-electronic-tongue-sensors
#6
Laura Isabell Immohr, Roy Turner, Miriam Pein-Hackelbusch
This article presents data, which can be applied for a pre-performance test of self-developed electronic tongue sensors. Contained data is related to the research article "Impact of Sodium Lauryl Sulfate in oral liquids on E-Tongue Measurements" (http://dx.doi.org/10.1016/j.ijpharm.2016.10.045; (L.I. Immohr, R. Turner, M. Pein-Hackelbusch, 2016) [1]). Sensor responses were obtained from 10 subsequent measurements and four different concentrations of quinine hydrochloride by electronic tongue (TS-5000Z, Insent Inc...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27920856/tongue-base-schwannoma-differential-diagnosis-and-imaging-features-with-a-case-presentation
#7
Zain Badar, Zerwa Farooq, Daniel Zaccarini, Sajeev R Ezhapilli
Schwannomas are slow growing, encapsulated neoplasms that arise from the nerve sheath. A vast majority of these benign neoplasms occur in the head and neck region, most commonly involving the 8th cranial nerve. Schwannomas arising from the base of tongue are very rare and, thus, can easily escape the list of differential diagnosis for a posterior tongue mass. A systematic approach is recommended for diagnosis of a posterior tongue mass, with neoplastic, infectious, and congenital categories. We report a case of a 24-year-old female, who presented with pressure sensation in the throat...
December 2016: Radiology case reports
https://www.readbyqxmd.com/read/27917797/investigation-of-macc1-gene-expression-in-head-and-neck-cancer-and-cancer-stem-cells
#8
Ebu Evran, Hilal Şahin, Kübra Akbaş, Sadik Çiğdem, Esra Gündüz
PURPOSE: By investigating the MACC1 gene (metastasis-associated in colon cancer 1) in cancer stem cells (CSC) resistant to chemotherapy and in cancer stem cells (CSC) resistant to chemotherapy and in cancer cells (CS) sensitive to chemotherapy we determineda steady expression in both types of cells in head and neck cancer. In conformity with the result we examined if this gene could be a competitor gene for chemotherapy. According to literature, the MACC1 gene shows a clear expression in head and neck cancer cells [1]...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27908069/associations-between-tongue-movement-pattern-consistency-and-formant-movement-pattern-consistency-in-response-to-speech-behavioral-modifications
#9
Antje S Mefferd
The degree of speech movement pattern consistency can provide information about speech motor control. Although tongue motor control is particularly important because of the tongue's primary contribution to the speech acoustic signal, capturing tongue movements during speech remains difficult and costly. This study sought to determine if formant movements could be used to estimate tongue movement pattern consistency indirectly. Two age groups (seven young adults and seven older adults) and six speech conditions (typical, slow, loud, clear, fast, bite block speech) were selected to elicit an age- and task-dependent performance range in tongue movement pattern consistency...
November 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27906850/isolated-hypoglossal-nerve-palsy-mimicking-a-base-of-tongue-tumor
#10
Daniela Francesca Nestola, Mariangela Lombardi, Matteo Brucoli, Francesco Pia, Paolo Aluffi
Isolated paralysis of hypoglossal nerve is uncommon, generally being associated with other neuropathies. A careful differential diagnosis is necessary to recognize the underlying diseases, some of which can be life-threatening. The authors report a patient of an 80-year-old woman presenting with an isolated hypoglossal palsy, mimicking a tongue neoplasm. Through a careful clinical workup and thanks to the aid of the imaging, it was possible to identify the presence of signal alterations due to a subacute denervation of the affected hemitongue and to exclude the presence of a tumor...
November 30, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27905120/incidence-of-contralateral-bilateral-nodes-in-the-human-papillomavirus-era
#11
Andrew G Tritter, Vikas Mehta, Madeleine Samuelson, Ginger deGravelle, Xiaohui Ma, Tara Medlin-Moore, Amol Takalkar, Gloria Caldito, Cherie-Ann O Nathan
OBJECTIVES/HYPOTHESIS: HPV-positive oropharyngeal squamous cell carcinoma has a more favorable prognosis when compared to HPV-negative disease, regardless of the presence of nodal metastases. However, the importance of contralateral neck treatment based on HPV status has not been well studied. Given the historically poor prognostic implications of cervical nodal metastases, this study sought to elucidate the relationship between HPV status and contralateral/bilateral nodal metastasis in patients with oropharyngeal squamous cell carcinoma...
December 1, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27898192/reappraising-hyalinizing-clear-cell-carcinoma-a-population-based-study-with-molecular-confirmation
#12
Juan C Hernandez-Prera, Ricky Kwan, Joseph Tripodi, Simion Chiosea, Carlos Cordon-Cardo, Vesna Najfeld, Elizabeth G Demicco
BACKGROUND: Hyalinizing clear cell carcinoma (HCCC) is a rare malignancy, characterized by EWSR1-ATF1 gene fusion, whose behavior is poorly understood, as it was for many years considered a diagnosis of exclusion. METHODS: All available salivary gland carcinomas (n = 594) from our institution were reviewed. Diagnosis of HCCC was confirmed by fluorescence in situ hybridization (FISH) for EWSR1. Literature review was performed. RESULTS: We found 15 patients with HCCCs (10 women, 5 men), 13 with EWSR1 rearrangement...
November 29, 2016: Head & Neck
https://www.readbyqxmd.com/read/27893073/association-between-severity-of-obstructive-sleep-apnea-and-number-and-sites-of-upper-airway-operations-with-surgery-complications
#13
Zamzil Amin Asha'ari, Jamalludin Ab Rahman, Abdul Hadi Mohamed, Kahairi Abdullah, Wan Ishlah Leman
Importance: In patients with obstructive sleep apnea (OSA), operative risks depend on the severity of the underlying OSA and the invasiveness of the surgical procedure. Objective: To investigate the nature of the associations between the severity of OSA and the number and anatomical sites of upper airway operations with operative complications. Design, Setting, and Participants: This retrospective study included adult patients diagnosed with OSA (apnea-hypopnea index [AHI], >5) who underwent upper airway surgery at a single tertiary referral hospital between October 1, 2008, and October 1, 2015...
November 23, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27891744/inducing-speech-errors-in-dysarthria-using-tongue-twisters
#14
Heather Kember, Kathryn Connaghan, Rupal Patel
Although tongue twisters have been widely use to study speech production in healthy speakers, few studies have employed this methodology for individuals with speech impairment. The present study compared tongue twister errors produced by adults with dysarthria and age-matched healthy controls. Eight speakers (four female, four male; mean age = 54.5 years) with spastic (mixed-spastic) dysarthria of varying aetiology (cerebral palsy, multiple sclerosis, multiple system atrophy) and eight controls (four female, four male; mean age = 56...
November 27, 2016: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/27891616/human-papillomavirus-induced-oropharyngeal-cancer-in-hispanics-in-the-united-states
#15
Giovana R Thomas, Kaming Lo, Raphael Nwojo
OBJECTIVES/HYPOTHESIS: Determine disparities in survival outcome and clinical presentation between Hispanic and non-Hispanic white patients with human papillomavirus-positive oropharyngeal squamous cell carcinoma. STUDY DESIGN: Retrospective clinical research. METHODS: Clinical data on Hispanics and non-Hispanic white patients with diagnosis of human papillomavirus/p16-positive oropharyngeal squamous cell carcinoma were drawn from a tumor registry from the University of Miami Hospitals and Clinics from 2008 to 2014...
November 28, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27889428/spectroscopic-and-e-tongue-evaluation-of-medicinal-plants-a-taste-of-how-rasa-can-be-studied
#16
Rama Jayasundar, Somenath Ghatak
BACKGROUND: The use of medicinal plants in Ayurveda is based on rasa, generally taken to represent taste as a sensory perception. This chemosensory parameter plays an important role in Ayurvedic pharmacology. OBJECTIVE: The aim is to explore the use of structuro-functional information deduced from analytical techniques for the rasa-based classification of medicinal plants in Ayurveda. MATERIALS AND METHODS: Methods of differential sensing and spectroscopic metabolomics have been used in select medicinal plants from three different taste categories (sweet, pungent and multiple taste): Tribulus terrestris, Vitis vinifera and Glycyrrhiza glabra from sweet category; Piper longum, Cuminum cyminum and Capsicum annum from pungent group; Emblica officinalis with five tastes...
November 23, 2016: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/27888823/investigating-kras-braf-mutation-in-oropharyngeal-squamous-cell-carcinomas-a-preliminary-study
#17
Ülkü Küçük, Ümit Bayol, Elif Usturalı Keskin, Emel Ebru Pala, İbrahim Çukurova, Mehmet Ali Çolak, Mustafa Değirmenci, Özge Özer, Altuğ Koç
OBJECTIVES: This study aims to investigate the role of KRAS/BRAF gene mutation in the pathogenesis of oropharyngeal squamous cell carcinoma (OSCC). PATIENTS AND METHODS: A total of 26 OSCC patients (23 males, 3 females; mean age 60 years; range 41 to 77 years) diagnosed between January 2003 and November 2013 were included in the study. The methods used in our study were quantitative fluorescence polymerase chain reaction for KRAS/BRAF mutation analysis. RESULTS: Ten of the tumors were located at the tongue base, 12 in the tonsil and four at the floor of mouth...
September 2016: Kulak Burun Boğaz Ihtisas Dergisi: KBB, Journal of Ear, Nose, and Throat
https://www.readbyqxmd.com/read/27888679/continuing-rise-in-oropharyngeal-cancer-in-a-high-hpv-prevalence-area-a-danish-population-based-study-from-2011-to-2014
#18
Amanda-Louise Fenger Carlander, Christian Grønhøj Larsen, David Hebbelstrup Jensen, Emilie Garnæs, Katalin Kiss, Luise Andersen, Caroline Holkmann Olsen, Maria Franzmann, Estrid Høgdall, Susanne K Kjær, Bodil Norrild, Lena Specht, Elo Andersen, Thomas van Overeem Hansen, Finn Cilius Nielsen, Christian von Buchwald
BACKGROUND: Human papillomavirus (HPV) is a critical element in the rising incidence of oropharyngeal squamous cell carcinoma (OPSCC), although whether this trend will continue, and the types of HPV responsible, are currently unknown. We previously demonstrated an increased incidence of HPV-related OPSCC in the high HPV prevalence area of Eastern Denmark from 2000 to 2010. Therefore, we investigated if the incidence for OPSCC continued to rise, the association to HPV and putative HPV-types in Eastern Denmark from 2011 to 14...
November 23, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27888638/should-surgeons-routinely-inform-patients-about-risks-of-taste-dysfunction-after-tongue-base-surgery-for-sleep-apnea
#19
Adam Kwinter, Kenny Pang, Brian Rotenberg
No abstract text is available yet for this article.
November 26, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27884445/taenia-hydatigena-in-pigs-in-burkina-faso-a-cross-sectional-abattoir-study
#20
Veronique Dermauw, Rasmané Ganaba, Assana Cissé, Boubacar Ouedraogo, Athanase Millogo, Zékiba Tarnagda, Anke Van Hul, Sarah Gabriël, Hélène Carabin, Pierre Dorny
Taenia hydatigena is a non-zoonotic cestode that has canines as definitive hosts and ruminants and pigs as intermediate hosts. In pigs, its presence causes cross-reactivity in serological testing for Taenia solium cysticercosis. Therefore, knowledge on the occurrence of T. hydatigena is paramount for validly estimating the seroprevalence of T. solium cysticercosis in pigs. In a cross-sectional abattoir study, we estimated the prevalence of T. hydatigena in pigs slaughtered in Koudougou, Burkina Faso. Carcasses of 452 pigs were examined by investigators for perceived and suspected T...
October 30, 2016: Veterinary Parasitology
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