keyword
MENU ▼
Read by QxMD icon Read
search

tongue base

keyword
https://www.readbyqxmd.com/read/28102598/novel-findings-of-left-ventricular-non-compaction-cardiomyopathy-microform-cleft-lip-and-poor-vision-in-patient-with-smc1a-associated-cornelia-de-lange-syndrome
#1
Tara L Wenger, Penny Chow, Stephanie C Randle, Anna Rosen, Craig Birgfeld, Joanna Wrede, Patrick Javid, Darcy King, Vivian Manh, Anne V Hing, Erin Albers
Relatively few patients with Cornelia de Lange syndrome (CdLS) due to SMC1A mutation have been reported, limiting understanding of the full extent of the phenotype. Compared to children with classic NIPBL-associated CdLS, patients with SMC1A-associated CdLS have a milder physical phenotype with prominent intellectual disability, high rate of cleft palate and absence of limb reductions. We present a patient with SMC1A-associated CdLS who had typical features including developmental delay, seizure disorder, feeding difficulties, hirsutism, and cleft palate...
February 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28102324/antiproliferative-and-apoptosis-inducing-effect-of-exo-protoporphyrin-ix-based-sonodynamic-therapy-on-human-oral-squamous-cell-carcinoma
#2
Yanhong Lv, Jinhua Zheng, Qi Zhou, Limin Jia, Chunying Wang, Nian Liu, Hong Zhao, Hang Ji, Baoxin Li, Wenwu Cao
Sonodynamic therapy (SDT) is an innovative modality for cancer treatment. But the biological effect of SDT on oral squamous cell carcinoma has not been studied. Our previous study has shown that endo-Protoporphyrin IX based SDT (ALA-SDT) could induce apoptosis in human tongue squamous carcinoma SAS cells through mitochondrial pathway. Herein, we investigated the effect of exo- Protoporphyrin based SDT (PpIX-SDT) on SAS cells in vitro and in vivo. We demonstrated that PpIX-SDT increased the ratio of cells in the G2/M phase and induced 3-4 times more cell apoptosis compared to sonocation alone...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28097311/association-of-lymphovascular-space-invasion-with-locoregional-failure-and-survival-in-patients-with-node-negative-oral-tongue-cancers
#3
Richard J Cassidy, Jeffrey M Switchenko, Naresh Jegadeesh, Mutlay Sayan, Matthew J Ferris, Bree R Eaton, Kristin A Higgins, Jeffrey T Wadsworth, Kelly R Magliocca, Nabil F Saba, Jonathan J Beitler
Importance: The indications for adjuvant therapy in resected oral tongue cancers are based on both clinical and pathological factors, with clear evidence for adjuvant radiation in patients with pathologically positive neck lymph nodes, positive margins, and extracapsular extension, but the data for patients with no nodal disease are sparse. Objective: To investigate determinants of failure and survival in patients with node-negative oral tongue cancer. Design, Setting, and Participants: Medical records for patients with oral tongue cancer treated with definitive surgery from 2003 to 2013 were reviewed...
January 12, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28096697/mir-486-3p-mir-139-5p-and-mir-21-as-biomarkers-for-the-detection-of-oral-tongue-squamous-cell-carcinoma
#4
Zujian Chen, Tianwei Yu, Robert J Cabay, Yi Jin, Ishrat Mahjabeen, Xianghong Luan, Lei Huang, Yang Dai, Xiaofeng Zhou
Oral tongue squamous cell carcinoma (TSCC) is a complex disease with extensive genetic and epigenetic defects, including microRNA deregulation. The aims of the present study were to test the feasibility of performing the microRNA profiling analysis on archived TSCC specimens and to assess the potential diagnostic utility of the identified microRNA biomarkers for the detection of TSCC. TaqMan array-based microRNA profiling analysis was performed on 10 archived TSCC samples and their matching normal tissues. A panel of 12 differentially expressed microRNAs was identified...
2017: Biomarkers in Cancer
https://www.readbyqxmd.com/read/28071886/boronlectin-polyelectrolyte-ensembles-as-artificial-tongue-design-construction-and-application-for-discriminative-sensing-of-complex-glycoconjugates-from-panax-ginseng
#5
Xiao-Tai Zhang, Shu Wang, Guo-Wen Xing
Ginsenoside is a large family of triterpenoid saponins from panax ginseng, which possesses various important biological functions. Due to the very similar structures of these complex glycoconjugates, it is crucial to develop powerful analytic method to identify ginsenosides qualitatively or quantitatively. We herein report an eight-channel fluorescent sensor array as artificial tongue to achieve the discriminative sensing of ginsenosides. The fluorescent cross-responsive array was constructed by four boronlectins bearing flexible boronic acid moieties (FBAs) with multiple reactive sites and two linear poly(phenylene-ethynylene) (PPEs)...
January 10, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28067994/identification-of-morphological-and-biochemical-changes-in-keratin-8-18-knock-down-cells-using-raman-spectroscopy
#6
S P Singh, Hunain Alam, Crismita Dmello, Hitesh Mamgain, Milind M Vaidya, Ramachandra Rao Dasari, C Murali Krishna
Accurate understanding of cellular processes and responses to stimuli is of paramount importance in biomedical research and diagnosis. Raman spectroscopy (RS), a label-free and nondestructive spectroscopic method has the potential to serve as a novel 'theranostics' tool. Both fiber-optic and micro-Raman studies have demonstrated efficacy in diagnostics and therapeutic response monitoring. In the present study, we have evaluated the potential of micro-Raman spectroscopic maps in identifying changes induced by loss of K8/18 proteins in a tongue cancer cell line...
January 9, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28062438/primary-non-hodgkin-s-lymphoma-of-the-tongue-a-diagnostic-dilemma-of-unusual-case-presentation
#7
Natheer Hashim Al-Rawi
Primary non-Hodgkin's lymphoma of the tongue is extremely uncommon, which makes its diagnosis quite challenging. A panel of 11 markers is used based on morphological differential diagnosis to elucidate the lymphoma subtype. A case of 43-year-old Egyptian man suffering from nodular mass on the right side of the tongue of 4 months duration is presented. No cervical lymphadenopathy was detected. No abdominal organomegaly was noted. The histological evaluation of incisional biopsy revealed a sheet of pleomorphic lymphoid cells with abnormal mitotic figures...
January 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28057753/a-novel-kleefstra-syndrome-associated-variant-that-affects-the-conserved-tplx-motif-within-the-ankyrin-repeat-of-ehmt1-leads-to-abnormal-protein-folding
#8
Patrick R Blackburn, Alexander Tischer, Michael T Zimmermann, Jennifer L Kemppainen, Sujatha Sastry, Amy E Knight Johnson, Margot A Cousin, Nicole J Boczek, Gavin Oliver, Vinod K Misra, Ralitza H Gavrilova, Gwen A Lomberk, Matthew Auton, Raul A Urrutia, Eric W Klee
Kleefstra syndrome (KS) (MIM# 610253), also known as 9q34 deletion syndrome, is an autosomal dominant disorder caused by haploinsufficiency of euchromatic histone methyltransferase-1 (EHMT1). The clinical phenotype of KS includes moderate to severe intellectual disability with absent speech, hypotonia, brachycephaly, congenital heart defects, and dysmorphic facial features with hypertelorism, synophrys, macroglossia, protruding tongue, and prognathism. Only a few cases of de novo missense mutations in EHMT1 giving rise to KS have been described...
January 5, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28056518/mucosal-sparing-radiation-therapy-in-resected-oropharyngeal-cancer
#9
Mauricio E Gamez, Michele Y Halyard, Michael L Hinni, Richard E Hayden, Thomas H Nagel, Carlos E Vargas, William W Wong, Kelly K Curtis, Matthew A Zarka, Daniel Ma, Samir H Patel
PURPOSE: To report the outcomes of patients with favorable risk oropharyngeal cancer that underwent adjuvant radiation therapy with omission of the primary site from the clinical target volume (CTV). MATERIAL/METHODS: A retrospective study of 40 patients treated with transoral surgery (TOS) followed by neck only radiation using intensity modulated radiation therapy (IMRT) with exclusion of the primary site. For all patients, a CTV of the primary surgical bed was contoured to obtain the estimated incidental dose to the primary site...
December 1, 2016: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28051949/stereological-assessment-of-the-total-number-of-hypoglossal-neurons-after-repeated-crush-injuries-to-the-hypoglossal-nerve-in-adult-rats
#10
Nanae Fukushima, Mika Karasawa, Kumiko Yokouchi, Norimi Sumitomo, Kyutaro Kawagishi, Tetsuji Moriizumi
OBJECTIVE: Retrograde neuronal cell death does not occur in mature motoneurons following the axonal injury of peripheral nerves. However, a previous study suggested that retrograde neuronal cell death does occur in adult rats after the creation of double lesions on the hypoglossal (XII) nerve based on a substantial decrease in the number of XII neurons. Using stereological methods, we examined neuronal apoptosis in XII neurons and the total number of XII neurons following repeated crush injuries to the XII nerve...
February 2017: Neurological Research
https://www.readbyqxmd.com/read/28051292/truxene-based-hyperbranched-conjugated-polymers-fluorescent-micelles-detect-explosives-in-water
#11
Wei Huang, Emanuel Smarsly, Jinsong Han, Markus Bender, Kai Seehafer, Irene Wacker, Rasmus R Schroeder, Uwe H F Bunz
We report two hyperbranched conjugated polymers (HCP) with truxene units as core and 1,4-didodecyl-2,5-diethynylbenzene as well as 1,4-bis(dodecyloxy)-2,5-diethynyl¬benzene as co-monomers. Two analogous poly(para-phenylene¬ethynylene)s (PPE) are also prepared as comparison to demonstrate the difference between the truxene and the phenyl moieties in their optical properties and their sensing performance. The four polymers are tested for nitroaromatic analytes and display different fluorescence quenching responses...
January 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28050511/oral-manifestations-of-job-s-syndrome-in-a-paediatric-dental-patient-a-case-report
#12
Jeswin James, Anupam Kumar Thekkeveetil, Kannan Vadakkepurayil
Job's syndrome or Hyperimmunoglobulin E Syndrome (HIES) is a rare primary immunodeficiency with marked increase in serum immunoglobulin E (IgE) levels and eczematous dermatitis. Individuals with HIES share characteristic facial features, with many oral manifestations like retained deciduous teeth, fissured tongue, missing permanent tooth buds, recurrent oral candidiasis, oral mucosal and gingival lesions. Two forms of disease have been identified based on the defective gene as autosomal dominant form and autosomal recessive form...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28050345/functional-mri-vs-navigated-tms-to-optimize-m1-seed-volume-delineation-for-dti-tractography-a-prospective-study-in-patients-with-brain-tumours-adjacent-to-the-corticospinal-tract
#13
Carolin Weiss Lucas, Irada Tursunova, Volker Neuschmelting, Charlotte Nettekoven, Ana-Maria Oros-Peusquens, Gabriele Stoffels, Andrea Maria Faymonville, Shah N Jon, Karl Josef Langen, Hannah Lockau, Roland Goldbrunner, Christian Grefkes
BACKGROUND: DTI-based tractography is an increasingly important tool for planning brain surgery in patients suffering from brain tumours. However, there is an ongoing debate which tracking approaches yield the most valid results. Especially the use of functional localizer data such as navigated transcranial magnetic stimulation (nTMS) or functional magnetic resonance imaging (fMRI) seem to improve fibre tracking data in conditions where anatomical landmarks are less informative due to tumour-induced distortions of the gyral anatomy...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28048795/su-f-j-226-structural-similarity-based-ultrasound-image-similarity-measurement
#14
Li Zhu, Ruixing Wang, Kele Xu
PURPOSE: We explore a method to measure the global ultrasound image similarity measurement, with the aim to facilitate abnormal region detection and automatic tracking failure re-initialization in the ultrasound image sequences. METHODS: Structural similarity is used in our similarity measurement framework. The classical structural similarity assesses the visual impact of three characteristics of the ultrasound imaging region from three aspects: luminance, contrast and structure...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048650/su-f-t-195-systematic-constraining-of-contralateral-parotid-gland-led-to-improved-dosimetric-outcomes-for-multi-field-optimization-with-scanning-beam-proton-therapy-promising-results-from-a-pilot-study-in-patients-with-base-of-tongue-carcinoma
#15
R Wu, C Crowford, R Georges, A Liu, M Amin, T Sio, B Gunn, F Poenisch, M Palmer, M Gillin, S Frank, X Zhu
PURPOSE: Treatment planning for Intensity Modulated Proton Therapy (IMPT) for head and neck cancer is time-consuming due to the large number of organs-at-risk (OAR) to be considered. As there are many competing objectives and also wide range of acceptable OAR constraints, the final approved plan may not be most optimal for the given structures. We evaluated the dose reduction to the contralateral parotid by implementing standardized constraints during optimization for scanning beam proton therapy planning...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048642/su-f-t-364-monte-carlo-dose-verification-of-volumetric-modulated-arc-therapy-plans-using-aapm-tg-119-test-patterns
#16
R Onizuka, F Araki, T Ohno, Y Nakaguchi
PURPOSE: To investigate the Monte Carlo (MC)-based dose verification for VMAT plans by a treatment planning system (TPS). METHODS: The AAPM TG-119 test structure set was used for VMAT plans by the Pinnacle3 (convolution/superposition), using a Synergy radiation head of a 6 MV beam with the Agility MLC. The Synergy was simulated with the EGSnrc/BEAMnrc code, and VMAT dose distributions were calculated with the EGSnrc/DOSXYZnrc code by the same irradiation conditions as TPS...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048438/th-ab-bra-01-a-novel-doubly-focused-multileaf-collimator-design-for-mr-guided-radiation-therapy
#17
H Li, S Mutic, D Low, O Green, G Fought, I Kawrakow, A Sharma, S Shvartsman, J Dempsey
PURPOSE: To describe the physical and dosimetric properties of a novel double-stack multileaf collimator (MLC). METHODS: One of the compromises made in the MLC design has been to employ linear-motion singly-divergent shapes. Because the MLC leading edge moves linearly, it is rounded to provide a consistent, albeit compromised penumbra. The MLC employed in the new linac-based MR-IGRT unit is designed to be doubly focused in that each leaf moves in an arc centered at the source, and the sides of the leaves are machined such that they lie parallel to a line between the leaf edge and the source...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048146/tu-ab-brc-04-commissioning-of-a-new-mlc-model-for-the-gepts-monte-carlo-system-a-model-based-on-the-leaf-and-interleaf-effective-density
#18
O Chibani, F Tahanout, C Ma
PURPOSE: To commission a new MLC model for the GEPTS Monte Carlo system. The model is based on the concept of leaves and interleaves effective densities METHODS: GEPTS is a Monte Carlo system to be used for external beam planning verification. GEPTS incorporates detailed photon and electron transport algorithms (Med.Phys. 29, 2002, 835). A new GEPTS model for the Varian Millennium MLC is presented. The model accounts for: 1) thick (1 cm) and thin (0.5 cm) leaves, 2) tongue-and-groove design, 3) High-Transmission (HT) and Low-Transmission (LT) interleaves, and 4) rounded leaf end...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047319/su-f-t-303-quantification-of-mlc-positioning-accuracy-in-vmat-delivery-of-head-and-neck-cancer-treatment
#19
X Li, F Yang
PURPOSE: Knowing MLC leaf positioning error over the course of treatment would be valuable for treatment planning, QA design, and patient safety. The objective of the current study was to quantify the MLC positioning accuracy for VMAT delivery of head and neck treatment plans. METHODS: A total of 837 MLC log files were collected from 14 head and neck cancer patients undergoing full arc VMAT treatment on one Varian Trilogy machine. The actual and planned leaf gaps were extracted from the retrieved MLC log files...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047176/su-c-bra-05-delineating-high-dose-clinical-target-volumes-for-head-and-neck-tumors-using-machine-learning-algorithms
#20
C Cardenas, A Wong, A Mohamed, J Yang, L Court, A Rao, C Fuller, M Aristophanous
PURPOSE: To develop and test population-based machine learning algorithms for delineating high-dose clinical target volumes (CTVs) in H&N tumors. Automating and standardizing the contouring of CTVs can reduce both physician contouring time and inter-physician variability, which is one of the largest sources of uncertainty in H&N radiotherapy. METHODS: Twenty-five node-negative patients treated with definitive radiotherapy were selected (6 right base of tongue, 11 left and 9 right tonsil)...
June 2016: Medical Physics
keyword
keyword
99302
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"