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https://www.readbyqxmd.com/read/29035400/protein-recognition-by-a-pattern-generating-fluorescent-molecular-probe
#1
Zohar Pode, Ronny Peri-Naor, Joseph M Georgeson, Tal Ilani, Vladimir Kiss, Tamar Unger, Barak Markus, Haim M Barr, Leila Motiei, David Margulies
Fluorescent molecular probes have become valuable tools in protein research; however, the current methods for using these probes are less suitable for analysing specific populations of proteins in their native environment. In this study, we address this gap by developing a unimolecular fluorescent probe that combines the properties of small-molecule-based probes and cross-reactive sensor arrays (the so-called chemical 'noses/tongues'). On the one hand, the probe can detect different proteins by generating unique identification (ID) patterns, akin to cross-reactive arrays...
October 16, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/29033209/a-worldwide-comparison-of-the-management-of-t1-and-t2-anterior-floor-of-the-mouth-and-tongue-squamous-cell-carcinoma-extent-of-surgical-resection-and-reconstructive-measures
#2
Katinka Kansy, Andreas Albert Mueller, Thomas Mücke, Friederike Koersgen, Klaus Dietrich Wolff, Hans-Florian Zeilhofer, Frank Hölzle, Winnie Pradel, Matthias Schneider, Andreas Kolk, Ralf Smeets, Julio Acero, Piet Haers, G E Ghali, Jürgen Hoffmann
INTRODUCTION: Microvascular surgery following tumor resection has become an important field of oral maxillofacial surgery (OMFS). Following the results on general aspects of current reconstructive practice in German-speaking countries, Europe and worldwide, this paper presents specific concepts for the management of resection and reconstruction of T1/T2 squamous cell carcinoma (SCC) of the anterior floor of the mouth and tongue. METHODS: The DOESAK questionnaire was distributed in three different phases to a growing number of maxillofacial units worldwide...
September 21, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29032218/the-hypoglossal-nerve-anatomical-study-of-its-entire-course
#3
Giorgio Iaconetta, Domenico Solari, Alessandro Villa, Clotilde Castaldo, Rosa Maria Gerardi, Gianluigi Califano, Stefania Montagnani, Paolo Cappabianca
OBJECT: Only a few anatomic studies concerning the entire course of the hypoglossal nerve (cranial nerve XII) have been reported. The purpose of the present study is to analyze all the relationships of the XII nerve with the surrounding structures from the brainstem to the tongue through a microscopic perspective. A comprehensive anatomically and clinically oriented classification of its different segments is proposed. METHODS: Ten formalin-fixed adult human cadaveric heads (20 sides) were dissected with the aim to explore the entire course of the XII cranial nerve via the lateral suboccipital, the far lateral partial or total transcondilar routes...
October 11, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29026807/airway-management-in-pierre-robin-sequence-the-vancouver-classification
#4
Wai-Yee Li, Alana Poon, Douglas Courtemanche, Cynthia Verchere, Sandra Robertson, Marija Bucevska, Claudia Malic, Jugpal S Arneja
BACKGROUND: Pierre Robin sequence (PRS) is a triad of micrognathia, glossoptosis, and respiratory distress. There is no standard clinical classification used in the management of neonatal airway in patients with PRS. The goal of our study was to review the presentation and management of patients with PRS and formulate a clinical grading system and treatment algorithm. METHODS: A 10-year retrospective review of all neonates diagnosed with PRS was performed after obtaining institutional ethics approval...
February 2017: Plastic Surgery
https://www.readbyqxmd.com/read/29023300/thyroglossal-duct-cyst-at-the-base-of-tongue-the-emerging-role-of-transoral-endoscopic-assisted-surgery
#5
Mario Turri-Zanoni, Paolo Battaglia, Paolo Castelnuovo
Cystic lesions involving the tongue base are rare, generally presenting in pediatric patients, and they may encompass different pathologies such as ranula, lingual ectopic thyroid, thyroglossal duct cyst (TDC), dysontogenetic cysts, benign, and malignant tumors.This paper describes the case of a 19-year-old girl with phonation impairment and mild dysphagia due to limited tongue protrusion and movements. Radiologic examinations revealed a bulky cystic lesion at the base of tongue with displacement of extrinsic lingual muscles...
October 11, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29018506/clinical-features-and-surgical-treatment-of-schwannoma-affecting-the-base-of-the-tongue-a-systematic-review
#6
REVIEW
Jenna Lamendola Sitenga, Gregory Alan Aird, Austin Nguyen, Adam Vaudreuil, Christopher Huerter
Introduction  Schwannomas of the head and neck account for 25-40% of all cases, with presentation at the base of the tongue as the most frequent site for intraoral tumors. Objectives  Here, a systematic review was conducted to include 15 cases of patients with schwannoma of the base of the tongue. Data Synthesis  Most patients presented with a single, painless, well-encapsulated nodule at the base of the tongue. These nodules were slow-growing, with an average of 13.3 months from onset to presentation...
October 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28987315/abscess-of-the-base-of-tongue-and-epiglottis
#7
Matthew L Wong
No abstract text is available yet for this article.
October 4, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28985038/characterizing-biochemical-and-morphological-variations-of-clinically-relevant-anatomical-locations-of-oral-tissue-in-vivo-with-hybrid-raman-spectroscopy-and-optical-coherence-tomography-technique
#8
Jianfeng Wang, Wei Zheng, Kan Lin, Zhiwei Huang
This study aims to characterize biochemical and morphological variations of the clinically relevant anatomical locations of in vivo oral tissue (i.e., alveolar process, lateral tongue, and floor of the mouth) by using hybrid Raman spectroscopy (RS) and optical coherence tomography (OCT) technique. A total of 1049 in vivo fingerprint (FP: 800-1800 cm(-1) ) and high wavenumber (HW: 2800-3600 cm(-1) ) Raman spectra were acquired from different oral tissue (alveolar process=331; lateral tongue=339, and floor of mouth=379) of 26 normal subjects in the oral cavity under the OCT imaging guidance...
October 6, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28984774/a-case-report-of-tongue-metastasis-from-lung-squamous-cell-carcinoma-and-literature-review
#9
REVIEW
Xiaolong Cheng, Zhenli Hu, Yipin Han, Chong Bai
RATIONALE: Tongue metastasis from lung cancer is extremely rare, and the prognosis of these patients is rather poor. PATIENT CONCERS: A 56-year-old man was found a 4-cm cavity lesion in the left upper lobe, which was initially misdiagnosed as tuberculosis. DIAGNOSES: A case of lung squamous cell carcinoma that metastasized to the base of a patient's tongue. INTERVATIONS: We send the biopsy of the lung and the tongue lesions for gene sequencing...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28983595/bufalin-induced-apoptosis-in-scc%C3%A2-4-human-tongue-cancer-cells-by-decreasing-bcl%C3%A2-2-and-increasing-bax-expression-via-the-mitochondria%C3%A2-dependent-pathway
#10
Han-Yu Chou, Fu-Shin Chueh, Yi-Shih Ma, Rick Sai-Chuen Wu, Ching-Lung Liao, Yung-Lin Chu, Ming-Jen Fan, Wen-Wen Huang, Jing-Gung Chung
The aim of the present study was to investigate the cytotoxic effects of bufalin on SCC‑4 human tongue cancer cells. Cell morphological changes and viability were examined using phase contrast microscopy and flow cytometry, respectively. The results indicated that bufalin induced morphological changes and reduced total viable cells. Apoptotic cell death was analyzed by DAPI staining and DNA gel electrophoresis; the results revealed that bufalin induced cell apoptosis. Levels of reactive oxygen species (ROS), Ca2+, nitric oxide (NO) and mitochondrial membrane potential (ΔΨm) were measured by flow cytometry, and bufalin was observed to increase Ca2+ and NO production, decrease the ΔΨm and reduce ROS production in SCC‑4 cells...
September 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28983077/regulation-of-root-patterns-in-mammalian-teeth
#11
Hyejin Seo, Jinsun Kim, Jae Joon Hwang, Ho-Gul Jeong, Sang-Sun Han, Wonse Park, Kanghyun Ryu, Hong Seomun, Jae-Young Kim, Eui-Sic Cho, Joo-Cheol Park, Kyung-Seok Hu, Hee-Jin Kim, Dong-Hyun Kim, Sung-Won Cho
Mammalian teeth have diverse pattern of the crown and root. The patterning mechanism of the root position and number is relatively unknown compared to that of the crown. The root number does not always match to the cusp number, which has prevented the complete understanding of root patterning. In the present study, to elucidate the mechanism of root pattern formation, we examined (1) the pattern of cervical tongues, which are tongue-like epithelial processes extending from cervical loops, (2) factors influencing the cervical tongue pattern and (3) the relationship among patterns of cusp, cervical tongue and root in multi-rooted teeth...
October 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28982840/human-papillomavirus-and-potentially-relevant-biomarkers-in-tonsillar-and-base-of-tongue-squamous-cell-carcinoma
#12
REVIEW
Anders Näsman, Cinzia Bersani, David Lindquist, Juan Du, Torbjörn Ramqvist, Tina Dalianis
Human papillomavirus (HPV)-positive tonsillar- and base of tongue cancer is increasing epidemically and has much better outcome than corresponding HPV-negative cancer and most other head and neck cancers with around 80% 3-year disease free survival with conventional radiotherapy and surgery. Consequently, most HPV-positive cancer patients may not require the intensified chemoradiotherapy given to many head and neck cancer patients and would, with tapered treatment, avoid several severe side-effects. Moreover, intensified therapy has not improved survival and treatment alternatives are needed...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28971745/minor-salivary-gland-carcinoma-of-the-oropharynx-a-population-based-analysis-of-1426-patients
#13
Alexander N Goel, Karam W Badran, Adam P G Braun, Alexander M Garrett, Jennifer L Long
Objective We sought to describe the patient, tumor, and survival characteristics of minor salivary gland carcinoma (MSGC) of the oropharynx using a large, population-based database. Study Design Cross-sectional analysis of the National Cancer Institute's SEER database (Surveillance, Epidemiology. and End Results). Subjects and Methods We reviewed the SEER database for all cases of MSGC of the oropharynx from 1988 to 2013. Relevant demographic, clinicopathologic, and survival variables were extracted and analyzed...
September 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28969885/tumor-pd-l1-expression-is-associated-with-improved-survival-and-lower-recurrence-risk-in-young-women-with-oral-cavity-squamous-cell-carcinoma
#14
G J Hanna, S-B Woo, Y Y Li, J A Barletta, P S Hammerman, J H Lorch
Young patients with oral cavity squamous cell carcinoma (OCSCC) are often recognized as a distinct epidemiological cohort. In this study, genomic and immune-based metrics were correlated with long-term outcomes for a young patient population treated at a single institution. A fully clinically annotated, retrospective cohort of 81 patients aged ≤45 years with OCSCC is described, and the impact of clinicopathological features on long-term survival outcomes is reported. Genomic and immune parameters were integrated utilizing a whole-exome sequencing and immunohistochemical approach among females in the cohort...
September 29, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28964317/vowel-intelligibility-in-children-with-cochlear-implants-an-acoustic-and-articulatory-study
#15
Christine Turgeon, Pamela Trudeau-Fisette, Elizabeth Fitzpatrick, Lucie Ménard
In child cochlear implant (CI) users, early implantation generally results in highly intelligible speech. However, for some children developing a high level of speech intelligibility may be problematic. Studies of speech production in CI users have principally been based on perceptual judgment and acoustic measures. Articulatory measures, such as those collected using ultrasound provide the opportunity to more precisely evaluate what makes child CI users more intelligible. This study investigates speech production and intelligibility in children with CI using acoustic and articulatory measures...
October 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28963823/predictors-of-contralateral-bilateral-nodal-disease-in-oropharyngeal-cancer-a-national-cancer-data-base-study
#16
Masanari G Kato, Mark A Ellis, Shaun A Nguyen, Terry A Day
BACKGROUND: Oropharyngeal squamous cell carcinoma (SCC) frequently presents with cervical metastasis. Roles of human papillomavirus (HPV) status, among other factors, on laterality are elusive. METHODS: The National Cancer Database was reviewed for oropharyngeal SCC diagnosed from 2010-2014. Predictors of clinically evident contralateral or bilateral nodal disease were identified. RESULTS: A total of 15 517 patients with oropharyngeal SCC met criteria...
September 30, 2017: Head & Neck
https://www.readbyqxmd.com/read/28960619/examination-of-intensive-care-unit-patients-oral-health
#17
Gul Gunes Celik, Ismet Eser
BACKGROUND: Oral health problems are common complications that most intensive care unit patients experience. There are many factors that affect oral health negatively and nurses have important responsibilities in this regard. AIM: The aim of this study was assessment of the intensive care unit patients' oral health and risk factors. METHODS: This study was planned as a descriptive study and conducted between December 2015 and June 2016, with 202 patients in 20 intensive care units of 6 hospitals in Turkey...
September 28, 2017: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/28955711/environmental-and-physiological-factors-associated-with-stamina-in-dogs-exercising-in-high-ambient-temperatures
#18
Patrick J Robbins, Meghan T Ramos, Brian M Zanghi, Cynthia M Otto
This IACUC approved study was performed to evaluate the environmental, physiological, and hematological components that contribute to stamina following successive bouts of exercise that included searching (5-min), agility (5-min), and ball retrieve (<10-min). Regularly exercised dogs (N = 12) were evaluated on five separate occasions. The population consisted of eight males and four females ranging in age from 8 to 23 months, which included six Labrador retrievers, three German shepherds, and one each English springer spaniel, German wirehaired pointer, and Dutch shepherd...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28955585/melkersson-rosenthal-syndrome-a-case-report
#19
Adil Basman, Mustafa Gumusok, Serife Degerli, Mustafa Kaya, Meryem Toraman Alkurt
Melkersson-Rosenthal Syndrome (MRS) is a rare disorder consisting of a triad of persistent or recurrent orofacial edema, relapsing facial paralysis and fissured tongue. It is rarely possible to observe all aspects of the classical triad at the same time, since these symptoms may appear in different times of life cycle. The most common symptom is orofacial edema. Although etiology of MRS is unclear, various factors such as infections, genetic predisposition, immune deficiency, food intolerance and stress have been held responsible...
2017: J Istanb Univ Fac Dent
https://www.readbyqxmd.com/read/28952337/gamma-knife-radiosurgery-for-glossopharyngeal-neuralgia-a-study-of-21-patients-with-long-term-follow-up
#20
Pierre-Yves Borius, Constantin Tuleasca, Xavier Muraciole, Laura Negretti, Luis Schiappacasse, Antoine Dorenlot, Maud Marguet, Michele Zeverino, Anne Donnet, Marc Levivier, Jean Regis
Objective Glossopharyngeal neuralgia (GPN) is a very rare condition, affecting the patient's quality of life. We report our experience in drug-resistant, idiopathic GPN, treated with Gamma Knife radiosurgery (GKRS), in terms of safety and efficiency, on a very long-term basis. Methods The study was opened, self-controlled, non-comparative and bicentric (Marseille and Lausanne University Hospitals). Patients treated with GKRS between 2003 and 2015 (models C, 4C and Perfexion) were included. A single 4-mm isocentre was positioned in the cisternal portion of the glossopharyngeal nerve, with a targeting based both on magnetic resonance imaging (MRI) and computed tomography (CT)...
January 1, 2017: Cephalalgia: An International Journal of Headache
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