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HPV type 11

Dana Whittemore, Lili Ding, Lea E Widdice, Darron A Brown, David I Bernstein, Eduardo L Franco, Jessica A Kahn
BACKGROUND: Previous studies have demonstrated racial and ethnic differences in the distribution of human papillomavirus (HPV) types among adult women with cervical precancers. The aim of this study was to determine whether the distribution of vaccine-targeted HPV types varies by race/ethnicity among unvaccinated young women. MATERIALS AND METHODS: A secondary analysis was performed using data from four studies of sexually experienced, unvaccinated, 13-26-year-old women...
October 18, 2016: Journal of Women's Health
Lydia S Murdiyarso, Melissa Kartawinata, Iffat Jenie, Grace Widjajahakim, Heriawaty Hidajat, Ruth Sembiring, I Made Nasar, Santoso Cornain, Farid Sastranagara, Ahmad Rusdan Handoyo Utomo
PURPOSE: We sought to evaluate prevalence, age-adjusted distribution, and impact of single and multiple high- and low-risk human papillomavirus (HPV) subtypes and their associations with cervical lesions. METHODS: Data were extracted from 11,224 women who underwent routine screening of HPV genotyping and liquid-based cytology co-testing. Fifteen high-risk (HR) and six low-risk (LR) HPV types were genotyped. RESULTS: Overall HPV prevalence was 10...
October 17, 2016: Cancer Causes & Control: CCC
Nicolas F Schlecht, Angela Diaz, Viswanathan Shankar, Arnold H Szporn, Maoxin Wu, Anne Nucci-Sack, Ken Peake, Howard D Strickler, Robert D Burk
BACKGROUND:  Uptake of the human papillomavirus (HPV) vaccine in the United States is slow, and the real-world effectiveness of the vaccine has not been assessed in high-risk adolescent populations. METHODS:  We conducted a longitudinal study of 1139 sexually-active, inner-city adolescent women receiving the 3-dose quadrivalent (4vHPV) vaccine. Cervical and anal specimens collected semi-annually were tested using a L1-PCR assay. Post-vaccination incidence of 4vHPV vaccine and non-vaccine HPV types, and risk of cervical cytological abnormalities, were assessed in relation to time-to-completion of all three vaccine doses...
October 12, 2016: Journal of Infectious Diseases
Laurențiu Pirtea, Dorin Grigoraş, Petru Matusz, Marilena Pirtea, Lavinia Moleriu, Anca Tudor, Răzvan Ilina, Cristina Secoşan, Florin Horhat, Octavian Mazilu
BACKGROUND: Persistent infections with high risk human papillomaviruses (HR-HPV) cause virtually all cervical cancers. METHODS: An observational study was conducted aiming to estimate the rate of HPV infection persistence after LEEP in patients with high grade squamous intraepithelial lesions (HSIL). Moreover, the study investigated if persistence is age related. For this reason a total of 110 patients were included between January 2010 and June 2015. RESULTS: At 6 months after LEEP the overall HPV infection persistence rate was 40...
October 6, 2016: BMC Surgery
V G Freitas, G R Focchi, E R Pereira, J E Levi, N M G Speck, J C Ribalta
The association between high-risk human papillomavirus (HPV) genotypes and p16 expression in indigenous women from the Xingu Indigenous Park, Brazil, was unknown. This study evaluated p16 expression in women with a histological diagnosis of cervical intraepithelial neoplasia (CIN) 3 or higher and correlated this expression with HPV genotypes to determine possible discrepancies in the expression of this marker. We evaluated 37 previously collected samples with different HPV genotypes and high-grade lesions diagnosed based on cytology, histology, and colposcopy...
September 16, 2016: Genetics and Molecular Research: GMR
Yuwei Chenzhang, Qiang Wen, Xianping Ding, Man Cao, Zuyi Chen, Xuemei Mu, Tao Wang
Cervical cancers almost are infected by human papillmavirus (HPV), encoding E6 and E7 oncoproteins which are regard as ideal targets on the mechanism of this disease and development of vaccines. HLA (human leukocyte antigen) participates in the local immune response to prevent tumor invasion and progression. But due to highly polymorphism of HLA, prediction shows its importance in this study. More effective immunoinformatics was used for predicting epitopes from HPV-16 E6 and E7, including T- and B-cell epitopes...
September 27, 2016: Immunology Letters
M Taberna, C Resteghini, B Swanson, R K L Pickard, B Jiang, W Xiao, M Mena, P Kreinbrink, E Chio, M L Gillison
BACKGROUND: Human Papillomavirus (HPV) is a cause of oropharyngeal squamous cell carcinoma (OPSCC), but its pathogenic role in larynx squamous cell carcinoma (LSCC) remains unclear. MATERIAL AND METHODS: A single-institutional, retrospective case-series was performed to estimate the etiological fraction (EF) for HPV in LSCC. Eligible cases included 436 consecutive cases of LSCC diagnosed (2005-2014) at The Ohio State University Medical Center. HPV DNA presence was detected by consensus primer PCR (Inno-LiPa) and HPV type-specific qPCR...
October 2016: Oral Oncology
Staci L Sudenga, B Nelson Torres, William J Fulp, Roberto Silva, Luisa L Villa, Eduardo Lazcano-Ponce, Donna J Ingles, Mark Stoler, Jane L Messina, Martha Abrahamsen, Maria Luiza Baggio, Jorge Salmeron, Manuel Quiterio, Anna R Giuliano
The purpose of this study was to assess whether the incidence of histopathologically confirmed condyloma and penile intraepithelial neoplasia (PeIN) and rates of genital HPV infection progression to these lesions differs by country (Brazil, Mexico, and the U.S.). At each visit, lesions were biopsied and were categorized by pathologic diagnoses. The Linear Array genotyping method was used to identify HPV genotypes from genital swabs, while the INNO-LiPA HPV Genotyping Extra method was used for tissue specimens...
September 28, 2016: International Journal of Cancer. Journal International du Cancer
Z M Li, L Q Zeng, X H Peng, L Z Mao, X L Sun, Y H Li, X P Luo
Objective: To study the clinical and pathological characteristics of HPV-negative cervical cancer patients. Methods: Retrospective analysis of 785 cervical cancer patients in Guangdong Women and Children Hospital from Jan. 2005 to Oct. 2015. By detecting high- risk HPV infection by flow-through hybridization genechip technique. Results: (1)Among 785 cases of cervical cancer, 71 cases were negative for HPV infection tested by genechip technique, accounting for 9.0%(71/785), and the relative light units/cut off(RLU/CO)ratios of these 71 cases were less than 1 by hybird capture Ⅱ(HC-Ⅱ)methods...
September 25, 2016: Zhonghua Fu Chan Ke za Zhi
Jane Shen-Gunther, Chiou-Miin Wang, Graham M Poage, Chun-Lin Lin, Luis Perez, Nancy A Banks, Tim Hui-Ming Huang
BACKGROUND: The Pap smear has remained the foundation for cervical cancer screening for over 70 years. With advancements in molecular diagnostics, primary high-risk human papillomavirus (hrHPV) screening has recently become an accepted stand-alone or co-test with conventional cytology. However, both diagnostic tests have distinct limitations. The aim of this study was to determine the association between HPV genotypes and cellular epigenetic modifications in three grades of cervical cytology for screening biomarker discovery...
2016: Clinical Epigenetics
Thanun Sritippho, Surawut Pongsiriwet, Nirush Lertprasertsuke, Kittisak Buddhachat, Thanapat Sastraruji, Anak Iamaroon
BACKGROUND: High-risk human papillomaviruses (HR-HPV), particularly types 16 and 18, have been found to play an important role in head and neck cancer, including oropharyngeal squamous cell carcinoma (OPSCC) and oral squamous cell carcinoma (OSCC). p16, a cell cycle inhibitor, has been postulated as a surrogate marker for HR-HPV, since p16 is aberrantly overexpressed in such lesions, especially in HR-HPV-positive OPSCC. However, p16 as a surrogate marker for HR-HPV infection in cancers of the oral cavity remains controversial...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
K Jeyachelvi, S Juwita, D Norwati
BACKGROUND: Cervical cancer though preventable is still the leading cause of cancer death among women secondary to breast cancer. Persistent infection with HPV has been causally linked to the disease. A school based HPV vaccination program was introduced in late 2010 in Malaysia and nurse support is essential for its success. OBJECTIVES: To determine nurses knowledge and attitudes about HPV infection and its vaccines, and factors associated with their knowledge...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Pradyot Prakash, Shashikant C U Patne, Ashish Kumar Singh, Mohan Kumar, Mukti Nath Mishra, Anil Kumar Gulati
AIMS: To devise nested multiplex polymerase chain reaction (NMPCR) protocol for detection of mucosal human papilloma viruses (HPVs) and typing of HPV-16 and -18 in formalin-fixed, paraffin-embedded (FFPE) tissues of carcinoma cervix (CaCx). SETTINGS AND DESIGN: Cross-sectional observational study. MATERIALS AND METHODS: NMPCR was done for simultaneous detection of HPV, targeting 134 bp L1 capsid gene employing GP+/mGP+ primers and typing of genotypes-16 and -18, targeting E6/E7 gene from 34 FFPE tissue blocks of CaCx and cervical intraepithelial neoplasia (CIN)...
July 2016: Journal of Global Infectious Diseases
Mariëtte I E van Poelgeest, Valeria V Visconti, Zohara Aghai, Vanessa J van Ham, Moniek Heusinkveld, Maarten L Zandvliet, A Rob P M Valentijn, Renske Goedemans, Caroline E van der Minne, Els M E Verdegaal, J Baptist M Z Trimbos, Sjoerd H van der Burg, Marij J P Welters
Adoptive transfer of tumor-specific T cells, expanded from tumor-infiltrating lymphocytes or from peripheral blood, is a promising immunotherapeutic approach for the treatment of cancer. Here, we studied whether the tumor-draining lymph nodes (TDLN) of patients with human papillomavirus (HPV)-induced cervical cancer can be used as a source for ACT. The objectives were to isolate lymph node mononuclear cells (LNMC) from TDLN and optimally expand HPV-specific CD4+ and CD8+ T cells under clinical grade conditions...
September 12, 2016: Cancer Immunology, Immunotherapy: CII
Maria Gabriella Donà, Barbara Pichi, Francesca Rollo, Tarik Gheit, Valentina Laquintana, Renato Covello, Edoardo Pescarmona, Giuseppe Spriano, Raul Pellini, Massimo Giuliani, Massimo Tommasino, Maria Benevolo
BACKGROUND: Conflicting data exist regarding the contribution of human papillomavirus (HPV) to the development of head and neck squamous cell papillomas. METHODS: Formalin-fixed paraffin-embedded papillomas were tested for 28 mucosal and 79 cutaneous HPVs using polymerase chain reaction (PCR)-based methods. RESULTS: Eighty-three papillomas (43 oropharyngeal, 31 oral, 6 laryngeal, and 3 nasopharyngeal) were analyzed. Twenty-four samples (28...
September 12, 2016: Head & Neck
Laura Ortega-Cervantes, Adriana Aguilar-Lemarroy, Aurora Elizabeth Rojas-García, Briscia Socorro Barrón-Vivanco, Verónica Vallejo-Ruiz, David Cantú-De León, Yael Yvette Bernal Hernández, Armando Jáuregui-Martínez, Irma Martha Medina-Díaz
OBJECTIVE: In Mexico cervical cancer (CC) is the most common cause of death from neoplasia in women. Study aimed to analyze the current distribution of Human papillomavirus (HPV) types in women from Nayarit, Mexico, with Squamous intraepithelial lesions (SIL) and Cervical cancer (CC). METHODOLOGY: Between January 2011 and July 2013, cervical samples were collected from female residents of the Mexican state of Nayarit and were analyzed by means of a LINEAR ARRAY® HPV genotyping test...
July 2016: International Journal of Health Sciences
Samantha E Rudolph, Attila Lorincz, Cosette M Wheeler, Patti Gravitt, Eduardo Lazcano-Ponce, Leticia Torres-Ibarra, Leith León-Maldonado, Paula Ramírez, Berenice Rivera, Rubí Hernández, Eduardo L Franco, Jack Cuzick, Pablo Méndez-Hernández, Jorge Salmerón
BACKGROUND: Cervical cancer remains an important cause of cancer mortality for Mexican women. HPV 16/18 typing may help to improve cervical cancer screening. Here we present the prevalence of high-risk human papillomavirus (hrHPV) including HPV16 and HPV18 from the FRIDA (Forwarding Research for Improved Detection and Access) population. METHODS: Beginning in 2013, we recruited 30,829 women aged 30-64 in Tlaxcala, Mexico. Cervical samples were collected and tested for 14 hrHPV genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68)...
2016: BMC Infectious Diseases
Lucas Tadeu Bidinotto, Carlos A R Véo, Edgar Aleman Loaiza, Alessandra Paulino Santos De França, Adriana Tarla Lorenzi, Luciana Albina Reis Rosa, Cristina Mendes De Oliveira, José Eduardo Levi, Cristovam Scapulatempo-Neto, Adhemar Longatto-Filho, Rui Manuel Reis
Anal cancer is a rare type of digestive tract disease, which has had a crescent incidence in a number of regions. Carcinomas are most frequently found, with squamous cell carcinoma (SCC) comprising ~95% of all anal tumors. The major risk factor for development of this type of tumor is human papillomavirus (HPV) infection. However, previous studies have identified patients with anal cancer that are HPV‑/p16‑and observed that they have a poorer outcome compared with HPV+/p16+ patients. This suggests that molecular profile may drive anal cancer progression...
October 2016: Molecular Medicine Reports
Junxian Ma, Jinshan Zhang, Yan Zhang, Tingting Lv, Jie Liu
BACKGROUND: The role of human papilloma virus (HPV) in oral lichen planus (OLP) is controversial. OBJECTIVES: The primary aim of the current study is to calculate the pooled risk estimates of HPV infection in OLP when compared with healthy controls. METHODS: Bibliographic searches were conducted in three electronic databases. Articles on the association between HPV and OLP were selected from case-control studies or cross-sectional studies, following predefined criteria...
2016: PloS One
Andrew G Schache, Ned G Powell, Kate S Cuschieri, Max Robinson, Sam Leary, Hisham Mehanna, Davy Rapozo, Anna Long, Heather Cubie, Elizabeth Junor, Hannah Monaghan, Kevin J Harrington, Christopher M Nutting, Ulrike Schick, Andy S Lau, Nav Upile, Jon Sheard, Kath Brougham, Catharine M L West, Ken Oguejiofor, Steve Thomas, Andy R Ness, Miranda Pring, Gareth J Thomas, Emma V King, Dennis McCance, Jacqueline A James, Michael Moran, Phil Sloan, Richard Shaw, Mererid Evans, Terry M Jones
A rising incidence of oropharyngeal squamous cell carcinoma (OPSCC) incidence has occurred throughout the developed world, where it has been attributed to an increasing impact of human papillomavirus (HPV) on disease etiology. This report presents the findings of a multicenter cross-sectional retrospective study aimed at determining the proportion of HPV-positive and HPV-negative OPSCC within the United Kingdom (UK). Archival tumor tissue blocks from 1602 patients previously diagnosed with OPSCC (2002-2011) were collated from 11 centers...
August 28, 2016: Cancer Research
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