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hyperthermia treatment

Zhila Rajaee, Samideh Khoei, Seied Rabi Mahdavi, Marzieh Ebrahimi, Sakine Shirvalilou, Alireza Mahdavian
The aim of this study was to investigate the effect of hyperthermia, 6 MeV electron radiation and combination of these treatments on cancer cell line DU145 in both monolayer culture and spheroids enriched for prostate cancer stem cells (CSCs). Flowcytometric analysis of the expression of molecular markers CD133 + /CD44 + was carried out to determine the prostate CSCs in cell line DU145 grown as spheroids in serum-free medium. Following monolayer and spheroid culture, DU145 cells were treated with different doses of hyperthermia, electron beam and combination of them...
February 17, 2018: Radiation and Environmental Biophysics
Rolf D Issels, Lars H Lindner, Jaap Verweij, Rüdiger Wessalowski, Peter Reichardt, Peter Wust, Pirus Ghadjar, Peter Hohenberger, Martin Angele, Christoph Salat, Zeljko Vujaskovic, Soeren Daugaard, Olav Mella, Ulrich Mansmann, Hans Roland Dürr, Thomas Knösel, Sultan Abdel-Rahman, Michael Schmidt, Wolfgang Hiddemann, Karl-Walter Jauch, Claus Belka, Alessandro Gronchi
Importance: Patients with soft tissue sarcoma are at risk for local recurrence and distant metastases despite optimal local treatment. Preoperative anthracycline plus ifosfamide chemotherapy improves outcome in common histological subtypes. Objective: To analyze whether the previously reported improvement in local progression-free survival by adding regional hyperthermia to neoadjuvant chemotherapy translates into improved survival. Design, Setting, and Participants: Open-label, phase 3 randomized clinical trial to evaluate the efficacy and toxic effects of neoadjuvant chemotherapy plus regional hyperthermia...
February 15, 2018: JAMA Oncology
Deniz Gazel, Mehmet Yılmaz
Antimicrobial chemotherapy and surgery are classical methods for treating infectious diseases. However, there is a need for alternative methods to cure infections caused by antibiotic-resistant pathogens, recurrent or chronic infections, and unreachable local infections in which the use of drugs or surgery is anatomically and physically restricted. Several microorganisms are known to be sensitive to mild hyperthermia, and this sensitivity is one of the potential benefits proposed for the host during an episode of fever...
February 15, 2018: International Journal of Hyperthermia
Jakub Mesicek, Kamil Kuca
The optimal light dose, heat generation, consequent heat spread, and an accurate thermal damage model, are key components of effective laser therapies. Recent advances in nanotechnology offer numerous possibilities on how to increase the efficacy of hyperthermia for tumour treatments. Gold nanoparticles are a promising candidate towards the achievement of this goal owing to their properties for efficiently converting light to heat. In this review, we summarise the numerical tools that are available for theoretical studies of gold-nanoparticle-mediated photo-thermal therapy...
February 15, 2018: International Journal of Hyperthermia
Kuen-Hau Chen, Bor-Chyuan Chen, Ching-Yen Ho
This paper conducts the thermal analysis of magnetic fluid with superparamagnetic nanoparticles subjected to an alternating magnetic field. Magnetic fluid hyperthermia (MFH) provides a potential method for cancer treatment, which has fewer side effects than chemotherapy and radiotherapy. Superparamagnetic nanoparticles dispersed in water are suitable for safe application of MFH. A well-defined hyperthermia should only kill the cancer cells without injuring neighbouring normal tissue. A key factor for hyperthermia is to correctly control the alternating magnetic field-induced temperature of the magnetic fluid in the tumour...
April 1, 2018: Journal of Nanoscience and Nanotechnology
Luminita Simion Labusca, Dumitru-Daniel Herea, Ecaterina Radu, Camelia Danceanu, Horia Chiriac, Nicoleta Lupu
The use of materials at nanoscale is currently of increasing interest for life sciences and medicine. Magnetic nanoparticles (MNPs) are under scrutiny for a large array of applications in nanomedicine as diagnostic and therapeutic tools. Proprietary Fe-Cr-Nb-B MNPs display heating properties that recommends them as potent agents for delivery of local hyperthermia for the treatment of solid tumours. Stem cell mediated delivery represents a safe and accurate modality to target remote or metastatic tumour sites...
July 1, 2018: Journal of Nanoscience and Nanotechnology
Pemantah Sandheeah Ramdeny, Colin Powell, Mallinath Chakraborty, Louise Hartley
A 6-month-old male infant with Stuve-Wiedemann syndrome (SWS) presented with an acute respiratory arrest secondary to a rhinovirus respiratory infection from which he was rapidly resuscitated. He developed an acute kidney injury requiring supportive treatment and on day 3 of his illness was noted to have developed severe rhabdomyolysis (creatine kinase level 132 040 U/L (normal <320 U/L)). He was born from consanguineous parents with homozygous mutations in the leukaemia inhibitory factor receptor. He had skeletal dysplasia with metabolic bone disease and episodes of hyperthermia with lactic acidosis...
February 8, 2018: BMJ Case Reports
Lu Han, Kai Guo, Fen Gu, Yun-Fei Zhang, Ke Li, Xi-Xi Mu, Hai-Jing Liu, Xiao-Dong Zhou, Wen Luo
In the present study, the effects of silibinin-loaded thermosensitive liposome-microbubble complex (STLMC) on rabbit liver VX2 tumors in sub-hyperthermia fields were investigated using two-dimensional ultrasonography (2D US), contrast-enhanced US (CEUS), hematoxylin and eosin (H&E) staining, immunohistochemistry and ultrastructure observation. 50 rabbits with VX2 liver tumors were divided into five groups: Sub-hyperthermia microwave ablation group (SHM), STLMC injection group (STLMC), SHM ablation plus STLMC injection group (SHM + STLMC), microbubble injection group and blank control group without any treatment...
February 2018: Experimental and Therapeutic Medicine
A Awaad, M A Adly, D Hosny
The World Health Organization has approved magnetic nanoparticles (MNP) for use as a contrast agent for magnetic resonance imaging or tumor hyperthermia treatment. MNP are toxic over time after intra-testicular injection. A clear strategy to ameliorate the toxic side effects of MNP in normal tissues after medical application has not yet been developed. We used an extract of Echinacea purpurea (EP) as a natural source of antioxidant and free radical scavenging product for detoxification of MNP in testicular tissues...
February 12, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
Shyam Sundar Krishnan, Pulak Nigam, Omar Bachh, Madabushi Chakravarthy Vasudevan
Hyperpyrexia is a rare and at times fatal condition seen in an Intensive Care Unit setup. We encountered a case of a 65-year-old patient with road traffic accident presenting with dorsal spine fracture at D10 level. He underwent decompression and fusion for the same. He developed hyperpyrexia of sudden onset on the 10th day of admission with no source of infection and adequate broad-spectrum antibiotic coverage with adequate thrombo-embolic prevention in place. The patient showed no response to antipyretic agents and other cooling methods...
January 2018: Indian Journal of Critical Care Medicine
David E Nichols, Charles S Grob
LSD (lysergic acid diethylamide) was discovered almost 75 years ago, and has been the object of episodic controversy since then. While initially explored as an adjunctive psychiatric treatment, its recreational use by the general public has persisted and on occasion has been associated with adverse outcomes, particularly when the drug is taken under suboptimal conditions. LSD's potential to cause psychological disturbance (bad trips) has been long understood, and has rarely been associated with accidental deaths and suicide...
February 1, 2018: Forensic Science International
Vânia Vilas-Boas, Begoña Espiña, Yury V Kolen'ko, Manuel Bañobre-Lopez, José A Duarte, Verónica C Martins, Dmitri Y Petrovykh, Paulo P Freitas, Felix D Carvalho
The use of targeted nanoparticles for magnetic hyperthermia (MHT) increases MHT selectivity, but often at the expense of its effectiveness. Consequently, targeted MHT is typically used in combination with other treatment modalities. This work describes an implementation of a highly effective monotherapeutic in vitro MHT treatment based on two populations of magnetic particles. Cells were sequentially incubated with two populations of magnetic particles: nonfunctionalized superparamagnetic nanoparticles and anti-CXCR4-functionalized particles...
February 5, 2018: Biointerphases
Tingting Wu, Dan Zhang, Qi Qiao, Xianya Qin, Conglian Yang, Miao Kong, Huan Deng, Zhiping Zhang
Combination of multiple modalities has shown great potential in cancer treatment with improved therapeutic effects and minimized side effects. Here we fabricated a kind of doxorubicin encapsulated biomimetic nanovesicles (NVs) by a facile method with near-infrared dye insertion in the membrane for combinatorial photothermal and chemotherapy. With innate biomimetic properties, NVs enhanced the uptake by tumor cells while reduced the phagocytosis of macrophages. Upon laser irradiation, NVs can convert the absorbed fluorescent energy into heat for effective tumor killing...
February 4, 2018: Molecular Pharmaceutics
Nan Lu, Wenpei Fan, Xuan Yi, Sheng Wang, Zhantong Wang, Rui Tian, Orit Jacobson, Yijing Liu, Bryant C Yung, Guofeng Zhang, Zhaogang Teng, Kai Yang, Minming Zhang, Gang Niu, Guangming Lu, Xiaoyuan Chen
Alleviation of tumor hypoxia has been the premise for improving the effectiveness of radiotherapy, which hinges upon the advanced delivery and rapid release of oxygen within the tumor region. Herein, we propose a "bubble-enhanced oxygen diffusion" strategy to achieve whole tumor oxygenation for significant radiation enhancement based on the "bystander effect". Towards this end, sub-50 nm CuS-modified and 64Cu labeled hollow mesoporous organosilica nanoparticles were constructed for tumor-specific delivery of O2-saturated perfluoropentane (PFP)...
January 31, 2018: ACS Nano
Jian-Ping Dou, Qun-Fang Zhou, Ping Liang, Jie Yu
Hyperthermia has been proposed as a promising treatment modality for its advantageous profiles such as mini/non-invasiveness, good tolerability, and cost-effectiveness. Quick development of nanotechnology in recent years has greatly broadened the application area of hyperthermia and endowed it with attractive new functions. Thermal sensitive nanostructures can absorb energy from an external source. They can control the therapeutic heating only in the targeted region without damage to normal tissues. They can also be loaded with therapeutic drugs and/or functionalized with imaging properties to construct multifunctional theranostic nanoplatforms...
January 29, 2018: Current Drug Metabolism
Tenho Hietanen, Mika Kapanen, Pirkko-Liisa Kellokumpu-Lehtinen
BACKGROUND: The effects of hyperthermia and irradiation, alone and in combination, on natural killer (NK) cell viability were investigated in vitro. The roles of interleukin-2 (IL-2) and interferon (IFN) α, β and γ in rescuing NK cells from hyperthermia and irradiation were studied. MATERIALS AND METHODS: Non-selected NK cells were used as effector cells and K-562 cells as target cells. NK and K-562 cells were treated at 37 to 45°C for 0 to 180 min. The cells were irradiated at room temperature using single doses from 0 to 60 Gy...
February 2018: Anticancer Research
Nedia Ben Achour, Thouraya Ben Younes, Ibtihel Rebai, Melika Ben Ahmed, Ichraf Kraoua, Ilhem Ben Youssef-Turki
INTRODUCTION: Anti-glutamic acid decarboxylase (anti-GAD65) antibodies are a rare cause of autoimmune encephalitis. This entity is mainly recognized in adults and very few cases were reported in children. We report on a paediatric case of anti-GAD encephalitis with severe presentation and uncontrollable dysautonomia. CASE STUDY: A 9-year-old girl was referred to our department for refractory seizures and behavioral disturbances. Brain magnetic resonance imaging (MRI) was normal...
January 12, 2018: European Journal of Paediatric Neurology: EJPN
Hwan-Jun Yoon, Hye-Seong Lee, Jik-Han Jung, Hyun Koo Kim, Ji Ho Park
Near-infrared photothermal therapy has been investigated extensively with regard to selective tumor eradication, yet its clinical translation has been limited due to the absence of FDA-approvable agents with effective phototherapeutic function and minimal systemic toxicity. In this work, we developed photothermally amplified therapeutic liposomes in an attempt to synergize chemotherapy and hyperthermia for effective cancer phototherapy. The anti-cancer drug cisplatin and the photothermal agent indocyanine green (ICG) were encapsulated in a thermo-sensitive liposomal formulation at the lipid/ICG ratio maximizing the ICG loading efficiency...
January 24, 2018: ACS Applied Materials & Interfaces
Madiha Saeed, Wenzhi Ren, Aiguo Wu
Nanotechnology has introduced new techniques and phototherapy approaches to fabricate and utilize nanoparticles for cancer therapy. These phototherapy approaches, such as photothermal therapy (PTT) and photodynamic therapy (PDT), hold great promise to overcome the limitations of traditional treatment methods. In phototherapy, magnetic iron oxide nanoparticles (IONPs) are of paramount importance due to their wide range of biomedical applications. This review discusses the basic concepts, various therapy approaches (PTT, PDT, magnetic hyperthermia therapy (MHT), chemotherapy and immunotherapy), intrinsic properties, and mechanisms of cell death of IONPs; it also provides a brief overview of recent developments in IONPs, with focus on their therapeutic applications...
January 24, 2018: Biomaterials Science
Nam Jun Kim, Yeonhee Ryu, Bong Hyo Lee, Suchan Chang, Yu Fan, Young S Gwak, Chae Ha Yang, Kyle B Bills, Scott C Steffensen, Jin Suk Koo, Eun Young Jang, Hee Young Kim
Methamphetamine (METH) increases metabolic neuronal activity in the mesolimbic dopamine (DA) system and mediates the reinforcing effect. To explore the underlying mechanism of acupuncture intervention in reducing METH-induced behaviors, we investigated the effect of acupuncture on locomotor activity, ultrasonic vocalizations, extracellular DA release in the nucleus accumbens (NAcs) using fast-scan cyclic voltammetry and alterations of brain temperature (an indicator of local brain metabolic activity) produced by METH administration...
January 23, 2018: Addiction Biology
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