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https://www.readbyqxmd.com/read/29035036/nanoprobe-synthesized-by-magnetotactic-bacteria-detecting-fluorescence-variations-under-dissociation-of-rhodamine-b-from-magnetosomes-following-temperature-ph-changes-or-the-application-of-radiation
#1
Edouard Alphandéry, Darine Abi Haidar, Olivier Seksek, Maxime Thoreau, Alain Trautmann, Nadege Bercovici, Florence Gazeau, François Guyot, Imène Chebbi
We report a method of fabrication of fluorescent magnetosomes, designated as MCR400, in which 400 μM of rhodamine B are introduced in the growth medium of AMB-1 magnetotactic bacteria and fluorescent magnetosomes are then extracted from these bacteria. These fluorescent magnetosomes behave differently from most fluorescent nanoprobes, which often lead to fluorescence losses over time due to photobleaching. Indeed, when MCR400 are heated to 30-90 °C, brought to an acidic pH, or exposed to radiations, we observed that their fluorescence intensity increased...
October 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29030300/gold-nanocage-decorated-ph-sensitive-micelle-for-highly-effective-photothermo-chemotherapy-and-photoacoustic-imaging
#2
Guoyong Zhou, Hong Xiao, Xiaoxia Li, Yi Huang, Wei Song, Liang Song, Meiwan Chen, Du Cheng, Xintao Shuai
A pH-sensitive copolymer PAsp(DIP)-b-PAsp(MEA) (PDPM) was synthesized and self-assembled to micelle loading chemotherapeutic drug doxorubicin (DOX) and introducing a gold nanocage structure for photothermo-chemotherapy and photoacoustic imaging. After further surface modification with polyethylene glycol (PEG), the DOX-loaded pH-sensitive gold nanocage (D-PGNC) around 100 nm possessed a uniform spherical structure with a pH-sensitive core of PAsp(DIP) incorporating DOX, an interlayer crosslinked via disulfide bonds and decorated with discontinuous gold shell, and a PEG corona...
October 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29028638/malignant-hyperthermia-versus-thyroid-storm-in-a-patient-with-symptomatic-graves-disease-a-case-report
#3
Sara M Strowd, Michael B Majewski, Jennifer Asteris
Malignant hyperthermia and thyroid storm are intraoperative emergencies with overlapping symptoms but different treatment protocols. We faced this diagnostic dilemma in a 25-year-old patient with symptomatic hyperthyroidism, elevated free T3 and free T4, and low thyroid-stimulating hormone from Graves disease despite treatment with propranolol 80 mg daily and methimazole 40 mg every 8 hours. During thyroidectomy, he developed hyperthermia and hypercarbia without tachycardia. When the rate of rise of PaCO2 and temperature accelerated, we treated the patient for malignant hyperthermia, a diagnosis subsequently confirmed by genetic testing...
October 12, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/29027224/immunomodulation-by-ionizing-radiation-impact-for-design-of-radio-immunotherapies-and-for-treatment-of-inflammatory-diseases
#4
REVIEW
Benjamin Frey, Michael Rückert, Lisa Deloch, Paul F Rühle, Anja Derer, Rainer Fietkau, Udo S Gaipl
Ionizing radiation is often regarded as an element of danger. But, danger responses on the cellular and molecular level are often beneficial with regard to the induction of anti-tumor immunity and for amelioration of inflammation. We outline how in dependence of radiation dose and fraction, radiation itself-and especially in combination with immune modulators-impacts on the innate and adaptive immune system. Focus is set on radiation-induced changes of the tumor cell phenotype and the cellular microenvironment including immunogenic cancer cell death...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29021707/pectinase-treated-panax-ginseng-protects-against-chronic-intermittent-heat-stress-induced-testicular-damage-by-modulating-hormonal-and-spermatogenesis-related-molecular-expression-in-rats
#5
Spandana Rajendra Kopalli, Kyu-Min Cha, Sang-Ho Lee, Ji-Hoon Ryu, Seock-Yeon Hwang, Min-Sik Jeong, Jong-Hwan Sung, Si-Kwan Kim
BACKGROUND: Elevated testicular temperature disrupts spermatogenesis and causes infertility. In the present study, the protective effect of enzymatically biotransformed Panax ginseng Meyer by pectinase (GINST) against chronic intermittent heat stress-induced testicular damage in rats was investigated. METHODS: Male Sprague-Dawley rats (4 wk old, 60-70 g) were divided into four groups: normal control (NC), heat-stress control (HC), heat-stress plus GINST-100 mg/kg (HG100), and heat-stress plus GINST-200 mg/kg (HG200) treatment groups...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29018170/temperature-activated-ion-channels-in-neural-crest-cells-confer-maternal-fever-associated-birth-defects
#6
Mary R Hutson, Anna L Keyte, Miriam Hernández-Morales, Eric Gibbs, Zachary A Kupchinsky, Ioannis Argyridis, Kyle N Erwin, Kelly Pegram, Margaret Kneifel, Paul B Rosenberg, Pavle Matak, Luke Xie, Jörg Grandl, Erica E Davis, Nicholas Katsanis, Chunlei Liu, Eric J Benner
Birth defects of the heart and face are common, and most have no known genetic cause, suggesting a role for environmental factors. Maternal fever during the first trimester is an environmental risk factor linked to these defects. Neural crest cells are precursor populations essential to the development of both at-risk tissues. We report that two heat-activated transient receptor potential (TRP) ion channels, TRPV1 and TRPV4, were present in neural crest cells during critical windows of heart and face development...
October 10, 2017: Science Signaling
https://www.readbyqxmd.com/read/28993133/physics-responsible-for-heating-efficiency-and-self-controlled-temperature-rise-of-magnetic-nanoparticles-in-magnetic-hyperthermia-therapy
#7
REVIEW
Zhila Shaterabadi, Gholamreza Nabiyouni, Meysam Soleymani
Magnetic nanoparticles as heat generation nanosources in hyperthermia treatment are still faced with many drawbacks for achieving sufficient clinical potential. In this context, increase in heating ability of magnetic nanoparticles in a safe alternating magnetic field and also approach to a precise control on temperature rise are two challenging subjects so that a significant part of researchers' efforts has been devoted to them. Since a deep understanding of Physics concepts of heat generation by magnetic nanoparticles is essential to develop hyperthermia as a cancer treatment with non-adverse side effects, this review focuses on different mechanisms responsible for heat dissipation in a radio frequency magnetic field...
October 6, 2017: Progress in Biophysics and Molecular Biology
https://www.readbyqxmd.com/read/28993129/separating-the-agony-from-ecstasy-r-3-4-methylenedioxymethamphetamine-has-prosocial-and-therapeutic-like-effects-without-signs-of-neurotoxicity-in-mice
#8
Daniel W Curry, Matthew B Young, Andrew N Tran, Georges E Daoud, Leonard L Howell
S,R(+/-)-3,4-methylenedioxymethamphetamine (SR-MDMA) is an amphetamine derivative with prosocial and putative therapeutic effects. Ongoing clinical trials are investigating it as a treatment for post-traumatic stress disorder (PTSD) and other conditions. However, its potential for adverse effects such as hyperthermia and neurotoxicity may limit its clinical viability. We investigated the hypothesis that one of the two enantiomers of SR-MDMA, R-MDMA, would retain the prosocial and therapeutic effects but with fewer adverse effects...
October 6, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28990364/synthesis-functionalization-and-design-of-magnetic-nanoparticles-for-theranostic-applications
#9
REVIEW
Jalal Mosayebi, Mehdi Kiyasatfar, Sophie Laurent
In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non-invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section...
October 9, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28988498/2-methyl-4-chlorophenoxyacetic-acid-mcpa-and-bromoxynil-herbicide-ingestion
#10
Angela L Chiew, Colin B Page, David Clancy, Ahmed Mostafa, Michael S Roberts, Geoffrey K Isbister
CONTEXT: Ingestion of bromoxynil and 2-methyl-4-chlorophenoxyacetic acid (MCPA) in combination is associated with high mortality. Toxicity is characterised by hyperthermia and metabolic acidosis. Dialysis is a proposed treatment, but little data exist regarding its effectiveness. CASE DETAILS: Case 1: A 50-year-old female presented 18 h post-ingestion of 200  mL of bromoxynil(200 g/L) and MCPA(200 g/L). She was agitated, tachycardic and tachypnoeic. She was intubated and continuous venovenous haemodiafiltration (CVVHDF) was commenced...
October 9, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28987207/keeping-cool-when-things-heat-up-during-a-malignant-hyperthermia-crisis
#11
Amy Dagestad, Melanie Hermann
This article describes the experience of a health care team at a maternity center during their care for a woman exhibiting an atypical presentation of malignant hyperthermia and outlines the steps taken to rapidly identify the condition and begin treatment to save her life. Key components in ensuring a positive outcome in a malignant hyperthermia crisis include increased awareness and readiness to effectively treat and reverse the signs and symptoms of this condition.
October 2017: Nursing for Women's Health
https://www.readbyqxmd.com/read/28978590/liver-transplantation-for-non-exertional-heat-stroke-related-acute-liver-failure
#12
Sandra Coenen, Khe Tran, Jubi de Haan, Rob de Man
Heat stroke is a life-threatening condition characterised by hyperthermia leading to multiple organ dysfunction. Acute liver failure is a rare and potentially fatal consequence of heat stroke. Management of heat stroke is mainly supportive but liver transplantation can be considered as the treatment of acute liver failure in heat stroke. However, literature on liver transplantation as a treatment for acute liver failure in heat stroke is scarce. Until now, no cases of liver transplantation for acute liver failure in non-exertional heat stroke have been reported...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28978031/hyperthermia-and-associated-changes-in-membrane-fluidity-potentiate-p2x7-activation-to-promote-tumor-cell-death
#13
Paola de Andrade Mello, Shu Bian, Luiz Eduardo Baggio Savio, Haohai Zhang, Jingping Zhang, Wolfgang Junger, Márcia Rosângela Wink, Guido Lenz, Andréia Buffon, Yan Wu, Simon Christopher Robson
Extracellular ATP (eATP) accumulation within the tumor microenvironment (TME) has the potential to activate purinergic signaling. The eATP evoked signaling effects bolster antitumor immune responses while exerting direct cytotoxicity on tumor cells and vascular endothelial cells, mediated at least in part through P2X7 receptors. Approaches to augment purinergic signaling in TME e.g. by ectonucleotidase CD39 blockade, and/or boosting P2X7 functional responses, might be used as immunomodulatory therapies in cancer treatment...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28971453/gold-rods-irradiated-with-ultrasound-for-combination-of-hyperthermia-and-cancer-chemotherapy
#14
Andre Barros, Carlos Austerlitz, Ioannis Gkigkitzis, Diana Campos, Jeyce Andrade, Christina Peixoto, Jaciana Aguiar, Silene Nascimento, Teresinha G Silva, Ioannis Haranas
PURPOSE: The aim of this study was to analyze feasibility (in vitro and in vivo) the use of hyperthermia produced by gold rods irradiated with ultrasound and their combination with chemotherapy with doxorubicin. MATERIALS AND METHODS: initially was determined the cell viability and Hsp70 levels after treatment by gold rods irradiated with ultrasound (GR+U) in cell culture. The pretreatment with GR+U combined with doxorubicin (DOX) was evaluated from IC50, caspase-3 expression and mechanisms of cell death by electron microscopy...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28971448/a-paris-system-based-implant-approach-to-hyperthermia-cancer-tumor-with-gold-seeds-and-ultrasound
#15
C Austerlitz, J Melo, A L S Barros, I Gkigkitzis, I Haranas, D Campos
A Paris system-based implant approach has been used to improve the bio-heat distribution from implanted gold rods in insonated tissues. Experiments with single-plane implants using parallel equidistant 1.018 ± 0.015 cm height and 0.136 ± 0.001 cm diameter 24-K gold rods) arranged in triangular and square shapes were performed in Mus musculus white mice (medial dorsal region). The mice were anesthetized and gold rods were implanted by means of a trocar needle and the implanted region was insonated with a 4-cm diameter transducer oscillating with a nominal frequency of 1 MHz and power of about 75 W...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28971442/preclinical-validation-of-the-located-hyperthermia-using-gold-macro-rods-and-ultrasound-as-an-effective-treatment-for-solid-tumors
#16
Andre L S Barros, Carlos Austerlitz, Ioannis Gkigkitzis, Diana Campos, Jeyce K F de Andrade, Teresinha G Silva, Silene C Nascimento, Ioannis Haranas
Hyperthermia, the procedure of raising the temperature of a part of or the whole body above normal for a defined period of time, is applied alone or as an adjunctive with various established cancer treatment modalities such as radiotherapy and chemotherapy. In this study used a method for inducing hyperthermia in solid tumors with a combination of gold macro rod (GR) and ultrasound, the feasibility of this technique was described only with computational models and in vitro. The Ehrlich tumor, derived from a mouse adenocarcinoma, has been used to investigate the bio-heat transfer and the effect of gold rods irradiated with ultrasound...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28969639/safety-and-efficacy-of-targeted-hyperthermia-treatment-utilizing-gold-nanorod-therapy-in-spontaneous-canine-neoplasia
#17
Elizabeth M Schuh, Roberta Portela, Heather L Gardner, Christian Schoen, Cheryl A London
BACKGROUND: Hyperthermia is an established anti-cancer treatment but is limited by tolerance of adjacent normal tissues. Parenteral administration of gold nanorods (NRs) as a photosensitizer amplifies the effects of hyperthermia treatment while sparing normal tissues. This therapy is well tolerated and has demonstrated anti-tumor effects in mouse models. The purpose of this phase 1 study was to establish the safety and observe the anti-tumor impact of gold NR enhanced (plasmonic) photothermal therapy (PPTT) in client owned canine patients diagnosed with spontaneous neoplasia...
October 2, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28960717/retrospective-evaluation-of-155-adult-equids-and-21-foals-with-tetanus-in-western-northern-and-central-europe-2000-2014-part-1-description-of-history-and-clinical-evolution
#18
Gaby van Galen, Claude Saegerman, Joke Rijckaert, Helene Amory, Lara Armengou, Barbora Bezdekova, Inge Durie, Rikke Findshøj Delany, Nathalie Fouché, Laura Haley, Michael Hewetson, Rene van den Hoven, Anna Kendall, Fernando Malalana, Jessika Muller Cavalleri, Tresemiek Picavet, Katja Roscher, Denis Verwilghen, Meret Wehrli Eser, Cornélie Westermann, Tim Mair
OBJECTIVE: To describe clinical data of hospitalized adult equids and foals with tetanus. DESIGN: Multicenter retrospective study (2000-2014). SETTING: Twenty Western, Northern, and Central European university teaching hospitals and private referral centers. ANIMALS: One hundred fifty-five adult equids (>6 months) and 21 foals (<6 months) with tetanus. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Information on geographic, annual and seasonal data, demographic- and management-related data, clinical history, clinical examination and blood analysis on admission, complications, treatments, and outcomes were described and statistically compared between adults and foals...
September 28, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28954600/disseminated-histoplasmosis-case-report-and-review-of-the-literature
#19
Séverine Evrard, Philippe Caprasse, Pierre Gavage, Myriam Vasbien, Jean Radermacher, Marie-Pierre Hayette, Rosalie Sacheli, Marjan Van Esbroeck, Lieselotte Cnops, Eric Firre, Laurent Médart, Filip Moerman, Jean-Marc Minon
Case report We report the case of a young Cameroonian woman who presented with cough, hyperthermia, weight loss, pancytopenia, and hepatosplenomegaly. A positive HIV serology was discovered and a chest radiography revealed a 'miliary pattern'. Bone marrow aspiration pointed out yeast inclusions within macrophages. Given the morphological aspect, the clinical presentation and immunosuppression, histoplasmosis was retained as a working hypothesis. Antiretroviral and amphotericin B treatments were promptly initiated...
September 28, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28946610/coptidis-rhizoma-prevents-heat-stress-induced-brain-damage-and-cognitive-impairment-in-mice
#20
Minho Moon, Eugene Huh, Wonil Lee, Eun Ji Song, Deok-Sang Hwang, Tae Hee Lee, Myung Sook Oh
Heat stress conditions lead to neuroinflammation, neuronal death, and memory loss in animals. Coptidis Rhizoma (CR) exhibits potent fever-reducing effects and has been used as an important traditional medicinal herb for treating fever. However, to date, the effects of antipyretic CR on heat-induced brain damages have not been investigated. In this study, CR significantly reduced the elevation of ear and rectal temperatures after exposure to heat in mice. Additionally, CR attenuated hyperthermia-induced stress responses, such as release of cortisol into the blood, and upregulation of heat shock protein and c-Fos in the hypothalamus and hippocampus of mice...
September 23, 2017: Nutrients
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