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Benign tumors of the ovary

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https://www.readbyqxmd.com/read/28315929/adnexal-masses-associated-with-peritoneal-involvement-diagnosis-with-ct-and-mri
#1
REVIEW
Audrey Ognong-Boulemo, Anthony Dohan, Christine Hoeffel, Agatha Stanek, François Golfier, Olivier Glehen, Pierre-Jean Valette, Pascal Rousset
Given the unique intra-peritoneal anatomic location of the adnexa, tubo-ovarian diseases can commonly spread into the peritoneal cavity. Peritoneal seeding may occur in a spectrum of adnexal conditions including infectious diseases, endometriosis, and benign or malignant primary or secondary ovarian tumors. CT is usually the imaging modality on which the concomitant involvement of the peritoneum and the ovary is depicted. The first diagnosis to be considered by the radiologist is generally peritoneal carcinomatosis from ovarian cancer but other conditions cited above have also to be borne in mind and may be suggested on the basis of careful assessment of CT findings or on further MR findings...
March 18, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28287942/fdg-pet-ct-pitfalls-in-gynecologic-and-genitourinary-oncologic-imaging
#2
Amish Lakhani, Sairah R Khan, Nishat Bharwani, Victoria Stewart, Andrea G Rockall, Sameer Khan, Tara D Barwick
The role of whole-body positron emission tomography (PET)/computed tomography (CT) with fluorodeoxyglucose ( FDG fluorodeoxyglucose ) is now established in the assessment of many gynecologic and genitourinary malignant tumors. FDG fluorodeoxyglucose PET/CT has been widely adopted for staging assessments in patients with suspected advanced disease, in cases of suspected disease recurrence, and for determining prognosis in a number of malignancies. A number of pitfalls are commonly encountered when reviewing FDG fluorodeoxyglucose PET/CT scans in gynecologic and genitourinary cases; these pitfalls can be classified into those that yield potential false-positive or false-negative results...
March 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28253891/evaluation-of-the-correlation-of-vasculogenic-mimicry-aldh1-kiss-1-and-macc1-in-the-prediction-of-metastasis-and-prognosis-in-ovarian-carcinoma
#3
Lan Yu, Bo Zhu, Shiwu Wu, Lei Zhou, Wenqing Song, Xiaomeng Gong, Danna Wang
BACKGROUND: Recurrence and metastasis are the usual manifestations of treatment failure of epithelial ovarian carcinoma (EOC). Vasculogenic mimicry (VM; blood supply development often seen in highly aggressive cancers), aldehyde dehydrogenase 1 (ALDH1, cancer stem cell biomarker), KiSS-1 (suppressor of tumor metastasis), and metastasis associated in colon cancer-1 (MACC1) are all useful predictive factors for metastasis and prognosis in various cancers. In this study, we analyzed associations among VM, ALDH1, KiSS-1, and MACC1 in EOC, and their respective correlations with clinicopathological characteristics and survival in EOC...
March 2, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28249923/morphoproteomics-identifies-the-ezh2-and-sirt1-pathways-as-potential-blocks-to-differentiation-in-yolk-sac-tumor-of-the-ovary-and-provides-therapeutic-options-a-case-study
#4
Yumi A Kojima, Binara Assylbekova, Bihong Zhao, Elizabeth Nugent, Robert E Brown
Yolk sac tumor of the ovary is a rare but highly malignant and aggressive germ cell tumor. The objective of this case study of an ovarian yolk sac tumor was to identify putative pathways that are known to pose a block in differentiation, both in early embryogenesis and in tumorigenesis, that might be amenable to low toxicity therapies designed to promote differentiation to a more benign state and prevent recurrent disease in such tumors. The enhancer of Zeste homolog 2 (EZH2), a histone methyl transferase, and silent mating type information regulation 2 homolog 1 (SIRT1), a NAD+ histone deacetylase, are two such pathways...
January 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28246900/multimodality-imaging-findings-of-massive-ovarian-edema-in-children
#5
Hisham Dahmoush, Sudha A Anupindi, Bruce R Pawel, Nancy A Chauvin
BACKGROUND: Massive ovarian edema is a rare benign condition that predominantly affects childbearing women as well as preadolescent girls. It is thought to result from intermittent or partial torsion of the ovary compromising the venous and lymphatic drainage but with preserved arterial supply. The clinical features of massive ovarian edema are nonspecific and can simulate tumors, leading to unnecessary oophorectomy. OBJECTIVE: To demonstrate imaging features that should alert radiologists to consider the diagnosis of massive ovarian edema preoperatively so that fertility-sparing surgery may be considered...
February 28, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28216128/mucinous-cystadenoma-in-children-and-adolescents
#6
Renee A Cowan, Erin N Haber, Fabio R Faucz, Constantine A Stratakis, Veronica Gomez-Lobo
STUDY OBJECTIVE: Mucinous cystadenomas (MCAs) are benign epithelial ovarian tumors that occur rarely in children and adolescents. As children and adolescents typically have their childbearing years ahead of them, conservative therapy is indicated. However, there is concern that ovarian cystectomy may be associated with significant recurrence risk in MCA. Furthermore, GNAS gene mutations are associated with McCune-Albright Syndrome, which is associated with cystic ovaries. We sought to evaluate the outcomes of children and adolescents with MCA treated conservatively...
February 16, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28208869/mature-cystic-teratoma-with-co-existent-mucinous-cystadenocarcinoma-in-the-same-ovary-a-diagnostic-dilemma
#7
Sanjeet Roy, Sramana Mukhopadhayay, Mayank Gupta, Anuradha Chandramohan
Mature cystic teratoma co-existing with a mucinous cystadenocarcinoma is an infrequently encountered entity with only a handful of cases reported till date. The possibilities in such a case are either a malignant transformation of a benign teratoma into adenocarcinoma or a collision tumor between a mature cystic teratoma and a mucinous tumour of either a primary ovarian surface epithelial-stromal origin or a secondary from a primary gastrointestinal tract tumour. The importance of distinguishing between the two entities has significant bearing on subsequent therapeutic management...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28137453/ovarian-preservation-from-tumors-and-torsions-in-girls-prospective-diagnostic-study
#8
Z B Stanković, K Sedlecky, D Savić, B J Lukač, I Mažibrada, S Perovic
STUDY OBJECTIVE: To develop a new decision tree system (DTS) for the management of adnexal masses in prepubertal and adolescent girls, aimed to improve the distinction between benign and malignant masses, help preserve affected ovaries during surgery and reduce the rate of surgical management of uncomplicated functional ovarian cysts. DESIGN: A prospective diagnostic study using clinical and ultrasound data collected for all patients under 19 years of age with adnexal masses managed between 2006 and 2015...
January 27, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28102088/hyperandrogenism-in-a-postmenopausal-woman-a-rare-case-of-ectopic-adrenal-cortical-gland
#9
Antonella Guarino, Luisa Di Benedetto, Valentina Giovanale, Gian Luca Rampioni Vinciguerra, Antonella Stoppacciaro, Filippo Bellati, Donatella Caserta
Most frequent causes of androgenic manifestation are Cushing's syndrome, PCO, benign and malignant androgen-secreting non adrenal tumors and iatrogenic hirsutism. Hyperplasia or neoplasms of ectopic adrenocortical gland are rare. We report a case of a 63-year old female with hirsutism and alopecia. Laboratory data highlighted increased levels of androgens. Diagnostic imaging revealed normal morphology of adrenocortical gland and ovaries. In view of the clinical picture and suspected diagnosis of extra-adrenal cause, she underwent bilateral salpingo-oophorectomy...
January 19, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28040143/intense-fluorodeoxyglucose-uptake-by-a-benign-sclerosing-stromal-tumor-of-the-ovary
#10
Takuji Tomimatsu, Yayoi Fukuda, Kazuya Mimura, Kiyoshi Yoshino, Hiroki Kato, Takahiro Tsuboyama, Yumiko Hori, Tadashi Kimura
No abstract text is available yet for this article.
December 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28025670/ovarian-borderline-tumors-in-the-2014-who-classification-evolving-concepts-and-diagnostic-criteria
#11
REVIEW
Steffen Hauptmann, Katrin Friedrich, Raymond Redline, Stefanie Avril
Borderline ovarian tumors (BOT) are uncommon but not rare epithelial ovarian neoplasms, intermediate between benign and malignant categories. Since BOT were first identified >40 years ago, they have inspired controversies disproportionate to their incidence. This review discusses diagnostic criteria for the histologic subtypes of BOT, highlighting areas of diagnostic challenges, ongoing controversies, and changes in terminology implemented by the recent 2014 WHO Classification of Tumours of the Female Genital Organs...
February 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27987343/mature-cystic-teratoma-coexisting-with-clear-cell-carcinoma-in-the-ovary
#12
Koki Shimura, Mariko Matsumoto, Takuya Sugahara, Takuro Yamamoto, Nozomi Ogiso, Yoji Urata, Tomoharu Okubo
Mature cystic teratoma (MCT) is the most common benign ovarian tumor; clear-cell carcinoma (CCC) is a relatively common malignant ovarian tumor in Japan, but there are few reports on the coexistence of MCT and CCC. Here we report a case of simultaneous MCT and CCC in the ovary and review the relevant literature. The patient was a 49-year-old woman. A 5-cm MCT was found in the left ovary on initial gynecological examination, and she was referred to hospital for treatment because it was expanding. Magnetic resonance imaging showed a multilocular cystic tumor 16 × 10 × 9...
December 17, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27981940/squamous-cell-carcinoma-arising-in-background-of-mature-cystic-teratoma
#13
Muhammad Zubair, Shoaib Naiyar Hashmi, Saeed Afzal, Iqbal Muhammad, Hafeez Ud Din, Syed Naeem Raza Hamdani
Mature cystic teratoma of ovary is a common benign adnexal tumor in females. Malignant transformation in a mature cystic teratoma of the ovary occurs in only 1 - 2% of cases. Most common malignant transformation is squamous cell carcinoma (70-80% of cases), occurring mostly in postmenopausal women with large sized cysts. Here, we report a case of 46-year lady who presented with pain in lower abdomen. Ultrasound and CT scan revealed complex adnexal mass measuring 16x9 cm. Size and older age of the patients should be regarded as important predictors of malignant transformation in mature cystic teratoma...
November 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27899985/possible-role-of-thymidine-phosphorylase-in-gynecological-tumors-as-an-individualized-treatment-strategy
#14
Masako Shida, Masanori Yasuda, Mariko Fujita, Masaki Miyazawa, Hiroshi Kajiwara, Takeshi Hirasawa, Masae Ikeda, Naruaki Matsui, Toshinari Muramatsu, Mikio Mikami
Thymidine phosphorylase (TP) is structurally similar to platelet-derived endothelial cell growth factor, and it activates 5-fluorouracil (5-FU) prodrugs and also promotes angiogenesis. In the present study, the possibility of using TP expression as a biomarker for 5-FU prodrugs, and the significance of TP as an angiogenic factor, were investigated in patients with gynecological tumors. The subjects enrolled in the study were 188 patients with gynecological tumors who provided informed consent and underwent tumor resection at the Department of Obstetrics and Gynecology of Tokai University Hospital between February 2002 and January 2010...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27888800/multipoint-kras-oncogene-mutations-potentially-indicate-mucinous-carcinoma-on-the-entire-spectrum-of-mucinous-ovarian-neoplasms
#15
Yi-Ju Lee, Ming-Yung Lee, Alexandra Ruan, Chi-Kuan Chen, Hao-Ping Liu, Chau-Jong Wang, Wan-Ru Chao, Chih-Ping Han
Kras mutation is a common phenomenon in many human neoplasms. We aimed to assess the Kras mutational status along the histological continuum from normal ovaries to the development of benign, borderline and malignant ovarian mucinous neoplasms. We analyzed 41 cases of malignant, 10 cases of borderline, 7 cases of benign mucinous ovarian tumors and 7 cases of normal ovarian tissue. The prevalence of Kras mutations in the normal ovary was 0.00% (n=0/7), while the prevalence in benign, borderline and malignant mucinous neoplasms was 57...
November 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27872782/angiosarcoma-arising-in-ovarian-mucinous-tumor-a-challenge-in-intraoperative-frozen-section-diagnosis
#16
Surapan Khunamornpong, Jongkolnee Settakorn, Kornkanok Sukpan, Tip Pongsuvareeyakul, Sumalee Siriaunkgul
Angiosarcoma of the ovary is rare but represents an aggressive type of malignant ovarian neoplasms. The purpose of this report is to describe the features of angiosarcoma arising in mucinous tumor that was misinterpreted as a benign vascular proliferation during the intraoperative consultation. A 45-year-old woman presented with an abdominal mass for 1 month. Exploratory laparotomy was performed. A 35 cm right ovarian mass submitted for intraoperative consultation was a multicystic mucinous tumor with an 8 cm area of hemorrhagic lesion between cystic locules...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27858913/laparoscopic-management-of-a-twisted-ovarian-leiomyoma-in-a-woman-with-10-weeks-gestation-case-report-and-literature-review
#17
REVIEW
Myounghwan Kim
BACKGROUND: Primary leiomyoma of the ovary is a rare benign ovarian tumor that only seldom causes acute abdomen. CASE SUMMARY: A 35-year-old gravida 1, para 0 woman presented with a history of acute lower abdominal pain, and 10 weeks of amenorrhea. The patient's physical examination revealed abdominal tenderness, defense, and rebound. On ultrasonographic examination, a solid mass measuring 9.3 × 7.8 cm was detected adjacent to the uterine fundus. The mass was preoperatively diagnosed as a twisted pedunculated subserosal uterine myoma...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27856389/mini-laparoscopy-of-removal-partial-adnexae-at-the-time-of-hysterectomy
#18
António Gutierrez Setúbal, João Sequeira Alves, Olga Lavado, Joana Faria
STUDY OBJECTIVE: To describe our technique of mini laparoscopic adnexectomy or salpingectomy at the time of total laparoscopic hysterectomy DESIGN: Step-by-step video explanation of our technique SETTING: The advantages of laparoscopic surgery have been widely recognised in the past two decades: improved vision, exposure, reduction in operative trauma because of smaller incisions and more gentle tissue´s handling, that result in a faster postoperative recovery. The technology development has allowed the use of smaller caliber instruments while maintaining the high standard surgical performance...
November 14, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27842595/long-term-survival-in-pseudo-meigs-syndrome-caused-by-ovarian-metastases-from-colon-cancer
#19
Yosuke Tajima, Hitoshi Kameyama, Saki Yamada, Ryoma Yagi, Masato Nakano, Masayuki Nagahashi, Yoshifumi Shimada, Jun Sakata, Takashi Kobayashi, Hajime Umezu, Toshifumi Wakai
BACKGROUND: Meigs' syndrome is defined as the co-existence of benign ovarian fibroma or fibroma-like tumor, ascites, and pleural effusion. In contrast, pseudo-Meigs' syndrome is defined as the co-existence of other ovarian or pelvic tumors, ascites, and pleural effusion. In Meigs' and pseudo-Meigs' syndromes, ascites and pleural effusion resolve promptly after the complete resection of the ovarian or pelvic tumor(s). Secondary ovarian tumors from colorectal gastrointestinal metastases rarely cause pseudo-Meigs' syndrome; only 11 cases of pseudo-Meigs' syndrome secondary to colorectal cancers have been reported in the literature...
November 14, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27833989/borderline-brenner-tumors-associated-with-ovarian-cyst-case-presentation
#20
Dinu Florin Albu, Cristina CrenguŢa Albu, Alexandru Marian Gogănău, Ştefan Dimitrie Albu, LaurenŢiu Mogoantă, Antoine Edu, Damian DiŢescu, Constantin Cristian Văduva
Borderline Brenner tumors represent quite a rare entity of ovarian tumors (about 2%) that develop from the surface ovarian epithelium. They are formed from papillary structures made of fibrovascular conjunctive axes covered by a transition epithelium, similar to the urinary bladder epithelium. According to the WHO classification, Brenner tumors present the following forms: benign, borderline and malignant. The benign ones are the most frequent, representing about 95%, the borderline represent about 5%, and the malignant ones less than 1%...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
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