Ju-Yoon Yoon, Maria Apellaniz-Ruiz, Anne-Laure Chong, Zena Slim, Stuart G Salfinger, Blaise A Clarke, Colin J R Stewart, William D Foulkes, W Glenn McCluggage
Embryonal rhabdomyosarcoma of the uterine cervix is a rare neoplasm which is almost invariably associated with pathogenic somatic or germline DICER1 mutations; patients with germline mutations have DICER1 syndrome. We report 2 subtle cervical embryonal rhabdomyosarcoma, one occurring in a 21-yr-old woman with a known history of DICER1 syndrome and the other in a 19-yr-old woman with no history of DICER1 syndrome or DICER1-associated neoplasms. Both neoplasms focally involved otherwise benign endocervical polyps and were characterized histologically by subtle areas of increased stromal cellularity, nuclear atypia and mitotic activity; there was focal nuclear staining of these areas with the skeletal muscle markers myogenin and myoD1...
September 1, 2021: International Journal of Gynecological Pathology