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https://www.readbyqxmd.com/read/28211682/exploring-the-influence-of-diamagnetic-ions-on-the-mechanism-of-magnetization-relaxation-in-co-iii-2ln-iii-2-ln-dy-tb-ho-butterfly-complexes
#1
Kuduva R Vignesh, Stuart K Langley, Keith S Murray, Gopalan Rajaraman
The synthesis and magnetic and theoretical studies of three isostructural heterometallic [Co(III)2Ln(III)2(μ3-OH)2(o-tol)4(mdea)2(NO3)2] (Ln = Dy (1), Tb (2), Ho (3)) "butterfly" complexes are reported (o-tol = o-toluate, (mdea)(2-) = doubly deprotonated N-methyldiethanolamine). The Co(III) ions are diamagnetic in these complexes. Analysis of the dc magnetic susceptibility measurements reveal antiferromagnetic exchange coupling between the two Ln(III) ions for all three complexes. ac magnetic susceptibility measurements reveal single-molecule magnet (SMM) behavior for complex 1, in the absence of an external magnetic field, with an anisotropy barrier Ueff of 81...
February 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28211516/high-efficient-oled-displays-prepared-with-the-air-gapped-bridges-on-quantum-dot-patterns-for-optical-recycling
#2
Hyo-Jun Kim, Min-Ho Shin, Joo-Suc Kim, Se-Eun Kim, Young-Joo Kim
An optically efficient structure was proposed and fabricated to realize high brightness organic light emitting diode (OLED) displays based on a white OLED prepared with the air-gapped bridges on the quantum dot (QD) patterns. Compared with a conventional white OLED display, in our experiments, the optical intensity of the proposed OLED display shows the enhancement of 58.2% in the red color and 16.8% in the green color after applying the air-gapped bridge structure on QD patterns of 20 wt% concentration. This enhancement comes from the two facts that the QD patterns downconvert unnecessary blue or blue/green light to the required green or red light and the air-gapped bridges increase the color conversion efficiency of QDs by optical recycling using total internal reflection (TIR) at the interface...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28209802/doublet-stimulation-increases-ca-2-binding-to-troponin-c-to-ensure-rapid-force-development-in-skeletal-muscle
#3
Anthony J Bakker, Tanya R Cully, Catherine D Wingate, Christopher J Barclay, Bradley S Launikonis
Fast-twitch skeletal muscle fibers are often exposed to motor neuron double discharges (≥200 Hz), which markedly increase both the rate of contraction and the magnitude of the resulting force responses. However, the mechanism responsible for these effects is poorly understood, likely because of technical limitations in previous studies. In this study, we measured cytosolic Ca(2+) during doublet activation using the low-affinity indicator Mag-Fluo-4 at high temporal resolution and modeled the effects of doublet stimulation on sarcoplasmic reticulum (SR) Ca(2+) release, binding of Ca(2+) to cytosolic buffers, and force enhancement in fast-twitch fibers...
February 16, 2017: Journal of General Physiology
https://www.readbyqxmd.com/read/28209185/health-literacy-in-a-community-with-low-levels-of-education-findings-from-chakaria-a-rural-area-of-bangladesh
#4
Susmita Das, Mohammad Nahid Mia, Syed Manzoor Ahmed Hanifi, Shahidul Hoque, Abbas Bhuiya
BACKGROUND: Health literacy (HL) helps individuals to make effective use of available health services. In low-income countries such as Bangladesh, the less than optimum use of services could be due to low levels of HL. Bangladesh's health service delivery is pluralistic with a mix of public, private and informally trained healthcare providers. Emphasis on HL has been inadequate. Thus, it is important to assess the levels of HL and service utilization patterns. The findings from this study aim to bridge the knowledge gap...
February 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28203262/participatory-epidemiology-the-contribution-of-participatory-research-to-epidemiology
#5
REVIEW
Mario Bach, Susanne Jordan, Susanne Hartung, Claudia Santos-Hövener, Michael T Wright
BACKGROUND: Epidemiology has contributed in many ways to identifying various risk factors for disease and to promoting population health. However, there is a continuing debate about the ability of epidemiology not only to describe, but also to provide results which can be better translated into public health practice. It has been proposed that participatory research approaches be applied to epidemiology as a way to bridge this gap between description and action. A systematic account of what constitutes participatory epidemiology practice has, however, been lacking...
2017: Emerging Themes in Epidemiology
https://www.readbyqxmd.com/read/28203238/differential-ability-of-bovine-antimicrobial-cathelicidins-to-mediate-nucleic-acid-sensing-by-epithelial-cells
#6
Arnaud Baumann, Mirjam Susanna Kiener, Brendan Haigh, Vincent Perreten, Artur Summerfield
Cathelicidins encompass a family of cationic peptides characterized by antimicrobial activity and other functions, such as the ability to enhance the sensing of nucleic acids by the innate immune system. The present study aimed to investigate the ability of the bovine cathelicidins indolicidin, bactenecin (Bac)1, Bac5, bovine myeloid antimicrobial peptide (BMAP)-27, BMAP-28, and BMAP-34 to inhibit the growth of bacteria and to enhance the sensing of nucleic acid by the host's immune system. BMAP-27 was the most effective at killing Staphylococcus aureus, Streptococcus uberis, and Escherichia coli, and this was dependent on its amphipathic structure and cationic charge...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28202242/effects-of-monovalent-and-divalent-metal-cations-on-the-aggregation-and-suspension-of-fe3o4-magnetic-nanoparticles-in-aqueous-solution
#7
Hao Wang, Xiaoli Zhao, Xuejiao Han, Zhi Tang, Shasha Liu, Wenjing Guo, Chaobing Deng, Qingwei Guo, Huanhua Wang, Fengchang Wu, Xiaoguang Meng, John P Giesy
There has been limited research investigating how the mechanisms of aggregation of magnetic nanoparticles (MNPs) are affected by inorganic ions. In this study, Na(+), Mg(2+), Ca(2+), Sr(2+) and Ba(2+) were selected to systematically study the aggregation mechanisms of Fe3O4 MNPs. The results indicated that divalent cations more significantly affected the stabilities of MNPs than Na(+) at low concentrations (e.g., 0.1mM) in a decreasing order of Ba(2+)>Sr(2+)>Ca(2+)>Mg(2+)>Na(+). Extended DLVO theory did not offer a satisfactory explanation for the above difference due because it ignores specific ion effects...
February 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28198618/self-enhancement-of-rotating-magnetocaloric-effect-in-anisotropic-two-dimensional-2d-cyanido-bridged-mn-ii-nb-iv-molecular-ferrimagnet
#8
Piotr Konieczny, Łukasz Michalski, Robert Podgajny, Szymon Chorazy, Robert Pełka, Dominik Czernia, Szymon Buda, Jacek Mlynarski, Barbara Sieklucka, Tadeusz Wasiutyński
The rotating magnetocaloric effect (RMCE) is a new issue in the field of magnetic refrigeration. We have explored this subject on the two-dimensional (2D) enantiopure {[Mn(II)(R-mpm)2]2[Nb(IV)(CN)8]}·4H2O (where mpm = α-methyl-2-pyridinemethanol) coordination ferrimagnet. In this study, the magnetic and magnetocaloric properties of single crystals were investigated along the bc//H easy plane and the a*//H hard axis. The observed small easy plane anisotropy is due to the dipole-dipole interactions. For fields higher than 0...
February 15, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28198096/treated-dentin-matrix-paste-as-a-novel-pulp-capping-agent-for-dentin-regeneration
#9
Jinlong Chen, Caiyun Cui, Xiangchen Qiao, Bo Yang, Mei Yu, Weihua Guo, Weidong Tian
Regenerating dentin and preserving pulp vitality are the two key targets for the treatment of dental pulp exposure. Calcium hydroxide (CH), the widely used capping agent, may induce potential tunnel defect in reparative dentin and cause inflammation or even necrosis in pulp tissues. This study aimed to produce a novel pulp capping agent with better bioactivities. Treated dentin matrix (TDM) paste (TDMP) was fabricated consisting of TDM powder and aqueous TDM extract. The chemical and biological characteristics of TDMP were investigated, and its effect on the odontogenic differentiation of dental pulp stem cells explored at gene and protein level; the therapeutic effect for pulp exposure in miniature swine was further verified...
February 15, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28197200/biodegradable-magnesium-wire-promotes-regeneration-of-compressed-sciatic-nerves
#10
Bo-Han Li, Ke Yang, Xiao Wang
Magnesium (Mg) wire has been shown to be biodegradable and have anti-inflammatory properties. It can induce Schwann cells to secrete nerve growth factor and promote the regeneration of nerve axons after central nervous system injury. We hypothesized that biodegradable Mg wire may enhance compressed peripheral nerve regeneration. A rat acute sciatic nerve compression model was made, and AZ31 Mg wire (3 mm diameter; 8 mm length) bridged at both ends of the nerve. Our results demonstrate that sciatic functional index, nerve growth factor, p75 neurotrophin receptor, and tyrosine receptor kinase A mRNA expression are increased by Mg wire in Mg model...
December 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28196691/healing-of-a-large-long-bone-defect-through-serum-free-in%C3%A2-vitro-priming-of%C3%A2-human-periosteum-derived-cells
#11
Johanna Bolander, Wei Ji, Jeroen Leijten, Liliana Moreira Teixeira, Veerle Bloemen, Dennis Lambrechts, Malay Chaklader, Frank P Luyten
Clinical translation of cell-based strategies for regenerative medicine demands predictable in vivo performance where the use of sera during in vitro preparation inherently limits the efficacy and reproducibility. Here, we present a bioinspired approach by serum-free pre-conditioning of human periosteum-derived cells, followed by their assembly into microaggregates simultaneously primed with bone morphogenetic protein 2 (BMP-2). Pre-conditioning resulted in a more potent progenitor cell population, while aggregation induced osteochondrogenic differentiation, further enhanced by BMP-2 stimulation...
February 7, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28196443/commentary-on-nerve-grafts-bridging-the-thenar-branch-of-the-median-nerve-to-the-ulnar-nerve-to-enhance-nerve-recovery-a-report-of-three-cases
#12
J Isaacs
No abstract text is available yet for this article.
March 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28191870/the-ndc80-complex-bridges-two-dam1-complex-rings
#13
Jae Ook Kim, Alex Zelter, Neil T Umbreit, Athena Bollozos, Michael Riffle, Richard Johnson, Michael J MacCoss, Charles L Asbury, Trisha N Davis
Strong kinetochore-microtubule attachments are essential for faithful segregation of sister chromatids during mitosis. The Dam1 and Ndc80 complexes are the main microtubule binding components of the Saccharomyces cerevisiae kinetochore. Cooperation between these two complexes enhances kinetochore-microtubule coupling and is regulated by Aurora B kinase. We show that the Ndc80 complex can simultaneously bind and bridge across two Dam1 complex rings through a tripartite interaction, each component of which is regulated by Aurora B kinase...
February 13, 2017: ELife
https://www.readbyqxmd.com/read/28186725/small-molecules-engage-hot-spots-through-cooperative-binding-to-inhibit-a-tight-protein-protein-interaction
#14
Degang Liu, David Xu, Min Liu, William Eric Knabe, Cai Yuan, Donghui Zhou, Mingdong Huang, Samy O Meroueh
Protein-protein interactions drive every aspect of cell signaling, yet there exist only few small-molecule inhibitors of these interactions. Despite our ability to identify critical residues known as hot spots, little is known about how to effectively engage them to disrupt protein-protein interactions. Here, we take advantage of the ease of preparation and stability of pyrrolinone 1, a small-molecule inhibitor of the tight uPAR•uPA interaction, to synthesize more than 40 derivatives and explore their effect on the protein-protein interaction...
February 10, 2017: Biochemistry
https://www.readbyqxmd.com/read/28183615/a-multi-walled-silk-fibroin-silk-sericin-nerve-conduit-coated-with-poly-lactic-co-glycolic-acid-sheath-for-peripheral-nerve-regeneration
#15
Jianwei Rao, Yan Cheng, Yanxiao Liu, Zhou Ye, Beilei Zhan, Daping Quan, Yangbin Xu
The linearly oriented multi-walled silk fibroin/silk sericin (SF/SS) nerve conduits (NCs) can provide physical cues similar to native peripheral nerve fasciculi, but the mechanical properties of which are not excellent enough. In this study, NCs with a novel and bionic design with dual structures were developed. The important features of our NCs is that the internal skeleton (the multi-walled SF/SS conduits) has a bionic structure similar to the architecture of native peripheral nerve fasciculi, which is beneficial for nerve regeneration, and the outer sheath (the hollow poly(lactic-co-glycolic acid) [PLGA] conduits) could provide strong mechanical protection for the internal skeleton...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183018/multifold-enhanced-synergistic-removal-of-nickel-and-phosphate-by-a-n-fe-dual-functional-bio-sorbent-mechanism-and-application
#16
Yan-Hong Zhang, Fu-Qiang Liu, Chang-Qing Zhu, Xiao-Peng Zhang, Meng-Meng Wei, Feng-He Wang, Chen Ling, Ai-Min Li
A novel (N,Fe)-dual-functional biosorbent (N/Fe-DB) capable of efficient synergistic removal of Ni(II) and H2PO4(-) from aqueous solution was synthesized. The adsorption capacities of Ni(II) and H2PO4(-) were both remarkably enhanced over 3 times compared with those in single systems. Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy confirmed that complexation of amino groups and ligand exchange of hydrous ferric oxide in N/Fe-DB played dominant roles. The electric double layer compressing and chelating ligand of deprotonated H2PO4(-) accounted for the enhanced removal of Ni(II) in binary system, while cation bridge interaction promoted uptake of H2PO4(-)...
January 31, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28181797/a-thermosensitive-heparin-poloxamer-hydrogel-bridge-afgf-to-treat-spinal-cord-injury
#17
Qingqing Wang, Yan He, Yingzheng Zhao, Huixu Xie, Qian Lin, Zili He, Xiaoyan Wang, Jiawei Li, Hongyu Zhang, Chenggui Wang, Fanghua Gong, Xiaokun Li, Huazi Xu, Qingsong Ye, Jian Xiao
Acidic fibroblast growth factor (aFGF) exerts a protective effect on spinal cord injury (SCI) but is limited by the lack of physicochemical stability andthe ability to cross the blood spinal cord barrier (BSCB). As promising biomaterials, hydrogels contain substantial amounts of water and a 3D porous structureand are commonly used to load and deliver growth factors. Heparin can not only enhance growth factor loading onto hydrogels but also can stabilize the structure and control the release behavior. Herein, a novel aFGF-loaded thermosensitive heparin-poloxamer (aFGF-HP) hydrogel was developed and applied to provide protection and regeneration after SCI...
February 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28181737/nitrogen-bridged-metallodiazaporphyrin-dimers-synergistic-effects-of-nitrogen-bridges-and-meso-nitrogen-atoms-on-structure-and-properties
#18
Masahiro Kawamata, Takuma Sugai, Mao Minoura, Yasuhisa Maruyama, Ko Furukawa, Cole Holstrom, Victor N Nemykin, Haruyuki Nakano, Yoshihiro Matano
The first examples of NH-bridged and pyrazine-fused metallodiazaporphyrin dimers were prepared from nickel(II) and copper(II) complexes of 3-amino-5,15-diazaporphyrin by Pd-catalyzed C-N cross-coupling and oxidative dimerization reactions, respectively. The synergistic effects of the nitrogen bridges and meso-nitrogen atoms play major roles in enhancing the light-harvesting properties and delocalization of an electron spin over the entire π-skeletons of the metallodiazaporphyrin dimers.
February 9, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28177025/stabilization-of-peptides-against-proteolysis-through-disulfide-bridged-conjugation-with-synthetic-aromatics
#19
Yaqi Chen, Tao Li, Jianguo Li, Shiyan Cheng, Jinghui Wang, Chandra Verma, Yibing Zhao, Chuanliu Wu
Peptides have been promising molecular scaffolds for the development of potential therapeutics with high affinity and specificity to biomacromolecules. However, their inherent proteolytic instability significantly hampers their biological applications. Strategies that can stabilize peptides against proteolytic digestion on the basis of noncovalent interactions-without extensive manipulation of the sequence or use of unnatural residues-are greatly desired. In this work, we developed a general, convenient, and efficient strategy for the stabilization of peptides against proteolysis, which involves noncovalent π-π interactions between aromatic amino acid residues in peptides and synthetic electron-deficient aromatics (NDI), together with the implication of steric hindrance (from the bulky NDI moiety), and the enhancement of peptide α-helicity...
February 8, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28174300/calmodulin-lobes-facilitate-dimerization-and-activation-of-estrogen-receptor-%C3%AE
#20
Zhigang Li, Yonghong Zhang, Andrew C Hedman, James B Ames, David B Sacks
Estrogen receptor alpha (ER-α) is a nuclear hormone receptor that controls selected genes, thereby regulating proliferation and differentiation of target tissues, such as breast. Gene expression controlled by ER-α is modulated by Ca2+ via calmodulin (CaM). Here we present the NMR structure of Ca2+-CaM bound to two molecules of ER-α (residues 287-305). The two lobes of CaM bind to the same site on two separate ER-α molecules (residues 292, 296, 299, 302 and 303), which explains why CaM binds two molecules of ER-α in a 1:2 complex and stabilizes ER-α dimerization...
February 7, 2017: Journal of Biological Chemistry
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