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Bridge enhanced

Jordan B Lee, Stephen H M Brown
Core stabilisation exercises are often promoted for purposes ranging from general fitness to high-performance athletics, and the prevention and rehabilitation of back troubles. These exercises, when performed properly, may have the potential to enhance torso postural awareness and control, yet the potential for achieving immediate gains has not been completely studied. Fourteen healthy young participants performed a single bout of non-fatiguing core stabilisation exercise that consisted of repeated sets of 2 isometric exercises, the side bridge and the four-point contralateral arm-and-leg extension...
September 20, 2017: Sports Biomechanics
Mattias Björnmalm, Kristofer J Thurecht, Michael Michael, Andrew M Scott, Frank Caruso
The interface of bio-nano science and cancer medicine is an area experiencing much progress but also beset with controversy. Core concepts of the field-e.g., the enhanced permeability and retention (EPR) effect, tumor targeting and accumulation, and even the purpose of "nano" in cancer medicine-are hotly debated. In parallel, considerable advances in neighboring fields are occurring rapidly, including the recent progress of "immuno-oncology" and the fundamental impact it is having on our understanding and the clinical treatment of the group of diseases collectively known as cancer...
September 19, 2017: ACS Nano
Zaixing Huang, Christine Sednek, Michael A Urynowicz, Hongguang Guo, Qiurong Wang, Paul Fallgren, Song Jin, Yan Jin, Uche Igwe, Shengpin Li
Isotopic studies have shown that many of the world's coalbed natural gas plays are secondary biogenic in origin, suggesting a potential for gas regeneration through enhanced microbial activities. The generation of biogas through biostimulation and bioaugmentation is limited to the bioavailability of coal-derived compounds and is considered carbon positive. Here we show that plant-derived carbohydrates can be used as alternative substrates for gas generation by the indigenous coal seam microorganisms. The results suggest that coalbeds can act as natural geobioreactors to produce low carbon renewable natural gas, which can be considered carbon neutral, or perhaps even carbon negative depending on the amount of carbon sequestered within the coal...
September 18, 2017: Nature Communications
Jianhua Hou, Kun Jiang, Ming Shen, Rui Wei, Xiaoge Wu, Faryal Idrees, Chuanbao Cao
Constructing the heterojunctions or designing the novel nanostructures are thought as effective methods to improve photocatalytic activities of semiconductors. Herein, a one-step green route was developed to fabricate bismuth oxyiodide/activated carbon (BiOI/C) composite. The prepared BiOI/C exhibit obviously red shifts and increased absorption range of visible light. The presence of Bi-C bonds confirms the heterojunction, on account of which the BiOI nanosheets tightly grew on the surface of carbon and subsequently provided the hierarchical structure, sufficient interfacial interaction and high specific surface area...
September 15, 2017: Scientific Reports
Jeong Soo Kim, Byung-Man Kim, Un-Young Kim, HyeonOh Shin, Jung Seung Nam, Deok-Ho Roh, Tae-Hyuk Kwon
We developed three types of dithieno[3,2-b;2',3'-d]thiophene (DTT)-based organic sensitizers for high-performance thin photoactive TiO2 films and investigate the simple but powerful molecular engineering of different types of bonding between the triarylamine electron donor and the conjugated DTT π-bridge by the introduction of single, double, and triple bonds. As a result, with only 1.3-μm transparent and 2.5-μm TiO2 scattering layers, the triple bond sensitizer (T-DAHTDTT) shows the highest power conversion efficiency (η = 8...
September 15, 2017: ACS Applied Materials & Interfaces
Le Thi Anh Hong, Young-Min Kim, Hee Hwan Park, Dong Hoon Hwang, Yuexian Cui, Eun Mi Lee, Stephanie Yahn, Jae K Lee, Soo-Chang Song, Byung Gon Kim
The cystic cavity that develops following injuries to brain or spinal cord is a major obstacle for tissue repair in central nervous system (CNS). Here we report that injection of imidazole-poly(organophosphazenes) (I-5), a hydrogel with thermosensitive sol-gel transition behavior, almost completely eliminates cystic cavities in a clinically relevant rat spinal cord injury model. Cystic cavities are bridged by fibronectin-rich extracellular matrix. The fibrotic extracellular matrix remodeling is mediated by matrix metalloproteinase-9 expressed in macrophages within the fibrotic extracellular matrix...
September 14, 2017: Nature Communications
Lin Qi, Mingshu Xiao, Fei Wang, Lihua Wang, Wei Ji, Tiantian Man, Ali Aldalbahi, M Naziruddin Khan, Govindasami Periyasami, Mostafizur Rahaman, Abdulaziz Alrohaili, Xiangmeng Qu, Hao Pei, Cheng Wang, Li Li
Highly sensitive and selective detection of heavy metal ions, such as Hg(2+), is of great importance because the contamination of heavy metal ions has been a serious threat to human health. Herein, we have developed poly-cytosine (polyC)-mediated surface-enhanced Raman scattering (SERS) nanotags as a sensor system for rapid, selective, and sensitive detection of Hg(2+) based on thymidine-Hg(2+)-thymidine (T-Hg(2+)-T) coordination and polyC-mediated Raman activity. The SERS nanotags exploit the mismatched T-T base pairs to capture Hg(2+) form T-Hg(2+)-T bridges, which induce the aggregation of nanotags giving rise to the drastic amplification in the SERS signals...
September 14, 2017: Nanoscale
B J Lehecka, Michael Edwards, Ryan Haverkamp, Lani Martin, Kambry Porter, Kailey Thach, Richard J Sack, Nils A Hakansson
BACKGROUND: Gluteal strength plays a role in injury prevention, normal gait patterns, eliminating pain, and enhancing athletic performance. Research shows high gluteal muscle activity during a single-leg bridge compared to other gluteal strengthening exercises; however, prior studies have primarily measured muscle activity with the active lower extremity starting in 90 ° of knee flexion with an extended contralateral knee. This standard position has caused reports of hamstring cramping, which may impede optimal gluteal strengthening...
August 2017: International Journal of Sports Physical Therapy
Shuping Wang, Shui Guan, Jianqiang Xu, Wenfang Li, Dan Ge, Changkai Sun, Tianqing Liu, Xuehu Ma
Engineering scaffolds with excellent electro-activity is increasingly important in tissue engineering and regenerative medicine. Herein, conductive poly(3,4-ethylenedioxythiophene) doped with hyaluronic acid (PEDOT-HA) nanoparticles were firstly synthesized via chemical oxidant polymerization. A three-dimensional (3D) PEDOT-HA/Cs/Gel scaffold was then developed by introducing PEDOT-HA nanoparticles into a chitosan/gelatin (Cs/Gel) matrix. HA, as a bridge, not only was used as a dopant, but also combined PEDOT into the Cs/Gel via chemical crosslinking...
September 12, 2017: Biomaterials Science
Luke A Farmer, Evan A Haidasz, Markus Griesser, Derek A Pratt
Diphenylamines are widely used to protect petroleum-derived products from autoxidation. Their efficacy as radical-trapping antioxidants (RTAs) relies on a balance of fast H-atom transfer kinetics and stability to one electron oxidation by peroxidic species. Both H-atom transfer and one-electron oxidation are enhanced by substitution with electron-donating substituents, such as the S-atom in phenothiazines, another important class of RTA. Herein we report the results of our investigations of the RTA activity of the structurally-related, but essentially ignored, phenoxazines...
September 8, 2017: Journal of Organic Chemistry
Hai-Ting Lv, Ying Cui, Yu-Min Zhang, Hua-Min Li, Guo-Dong Zou, Rui-Huan Duan, Jun-Tao Cao, Qiang-Shan Jing, Yang Fan
Organic donor-π-bridge-acceptor (D-π-A) dyes with arylamines as an electron donor have been widely used as photosensitizers for dye-sensitized solar cells (DSSCs). However, titanium-oxo clusters (TOCs) functionalized with this kind of D-π-A structured dye-molecule have rarely been explored. In the present study, the 4-dimethylaminobenzoate-functionalized titanium-oxo cluster [Ti6(μ3-O)6(OiPr)6(DMABA)6]·2C6H5CH3 (DMABA = 4-dimethylaminobenzoate) was synthesized and structurally characterized by single-crystal X-ray diffraction...
September 28, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Yunfang Zhou, Shuanghu Wang, Xuhua Ying, Yifan Wang, Peiwu Geng, Aiping Deng, Zhihong Yu
Multidrug resistance (MDR) against chemotherapeutic agents has become one of the major obstacles to successful cancer therapy and MDR-associated proteins (MRPs)-mediated drug efflux is the key factor for MDR. In this study, a redox-responsive polymer based on dextran (DEX) and indomethacin (IND), which could reduce MRPs-mediated efflux of chemotherapeutics, was synthesized, and the obtained polymer could spontaneously form stable micelles with well-defined core-shell structure and a uniform size distribution with an average diameter of 50 nm and effectively encapsulate doxorubicin (DOX); the micelles contain a disulfide bridge (cystamine, SS) between IND and DEX (DEX-SS-IND)...
2017: International Journal of Nanomedicine
Shaolong Zhou, Qiang Chang, Feng Lu, Malcolm Xing
Platelets-rich plasma (PRP) can produce growth factors (GFs) to improve angiogenesis. However, direct injection of PRP does not lead to highly localized GFs. The current study employs a mussel-inspired polydopamine to immobilize PRP on gelatin microspheres (GMs) with the purpose of bridging adipose micro-tissues to help implanted fat survive (GM-pDA-PRP). Enhanced PRP adhesion leads to a prolonged and localized production of GFs, which is verified by platelet counting and by ELISA of vascular endothelial growth factors (VEGFs) and of platelet derived growth factors (PDGFs)...
September 7, 2017: Advanced Healthcare Materials
Yuchen Wang, Maureen R Newman, Marian Ackun-Farmmer, Michael P Baranello, Tzong-Jen Sheu, J Edward Puzas, Danielle S W Benoit
Despite several decades of progress, bone specific drug delivery is still a major challenge. Current bone-acting drugs require high-dose systemic administration which decreases therapeutic efficacy and increases off-target tissue effects. Here, a bone-targeted nanoparticle (NP) delivery system for a β-catenin agonist, 3-amino-6-(4-((4-methylpiperazin-1-yl)sulfonyl)phenyl)-N-(pyridin-3-yl)pyrazine-2-carboxamide, a glycogen synthase kinase 3 beta (GSK-3β) inhibitor, was developed to enhance fracture healing...
September 7, 2017: ACS Nano
Isaiah N Gober, Marcey L Waters
In the design of small molecule receptors for polar guests, much inspiration has been taken from proteins that have adapted effective ways to selectively bind polar molecules in aqueous environments. Nonetheless, molecular recognition of hydrophilic guests in water by synthetic receptors remains a challenging task. Here we report a new synthetic receptor, A2I, with improved affinity and selectivity for a biologically important polar guest, dimethyllysine (Kme2). A2I was prepared via redesign of a small molecule receptor (A2B) that preferentially binds trimethyllysine (Kme3) using dynamic combinatorial chemistry (DCC)...
September 6, 2017: Organic & Biomolecular Chemistry
Ryan K Spencer, Allon I Hochbaum
Coiled coils are a robust motif for exploring amino acid interactions, generating unique supramolecular structures, and expanding properties of biological based ma- terials. A recently discovered antiparallel coiled-coil hexamer (ACC-Hex, peptide 1) exhibits a unique interaction in which Phe and Ile residues from adjacent α-helices interact to form a Phe-Ile zipper within the hydrophobic core. Analysis of the X-ray crystallographic structure of ACC-Hex suggests that the stability of the six-helix bundle relies on specific interactions between the Phe and Ile residues...
September 6, 2017: Biochemistry
Fatma Demir Duman, Merve Erkisa, Rouhullah Khodadust, Ferda Ari, Engin Ulukaya, Havva Yagci Acar
AIM: We aim to develop folic acid (FA)-conjugated cationic Ag2S near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug efficacy and optical tracking in the NIR region. MATERIALS & METHODS: Cationic Ag2S NIRQDs were decorated with FA using a PEG bridge and loaded with DOX. In vitro studies were performed on FR-positive human cervical carcinoma cells and FR-negative A549 cells...
September 6, 2017: Nanomedicine
Ata M Kiapour, Braden C Fleming, Martha M Murray
BACKGROUND: Abnormal joint motion has been linked to joint arthrosis after anterior cruciate ligament (ACL) reconstruction. However, the relationships between the graft properties (ie, structural and anatomic) and extent of posttraumatic osteoarthritis are not well defined. HYPOTHESES: (1) The structural (tensile) and anatomic (area and alignment) properties of the reconstructed graft or repaired ACL correlate with the total cartilage lesion area 1 year after ACL surgery, and (2) side-to-side differences in anterior-posterior (AP) knee laxity correlate with the total cartilage lesion area 1 year postoperatively...
August 2017: Orthopaedic Journal of Sports Medicine
Alexander A Ganin, Phuoc Quach, Mahesh Panwar, Zachary A Collier, Jeffrey M Keisler, Dayton Marchese, Igor Linkov
Risk assessors and managers face many difficult challenges related to novel cyber systems. Among these challenges are the constantly changing nature of cyber systems caused by technical advances, their distribution across the physical, information, and sociocognitive domains, and the complex network structures often including thousands of nodes. Here, we review probabilistic and risk-based decision-making techniques applied to cyber systems and conclude that existing approaches typically do not address all components of the risk assessment triplet (threat, vulnerability, consequence) and lack the ability to integrate across multiple domains of cyber systems to provide guidance for enhancing cybersecurity...
September 5, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
Margaux Elie, Michael D Weber, Florent Di Meo, Fabien Sguerra, Jean-François Lohier, Robert B Pansu, Jean-Luc Renaud, Matthieu Hamel, Mathieu Linares, Rubén D Costa, Sylvain Gaillard
We report on the benefits of changing the bridging group X of bis-pyridyl ligands - i.e., Py-X-Py where X is NH, CH2, C(CH3)2 and PPh - on the photo- and electro-luminescent properties of a new family of luminescent cationic NHC copper(I) complexes (NHC : N-Heterocyclic Carbene). A joint experimental and theoretical study demonstrates that the bridging group rules the molecular conformation from a planar-like structure (X is NH and CH2) to a boat-like structure (X is C(CH3)2 and PPh), leading to i) 4-fold enhancement of the photoluminescence quantum yield (φem) without affecting the thermally activated delayed fluorescence mechanism, and ii) one order of magnitude reduction of the ionic conductivity (σ) of thin films...
September 5, 2017: Chemistry: a European Journal
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