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Irena Sniecinski, Jerard Seghatchian
Clinical practice and related diagnostic, development and research [DDR] strategies in pediatric transfusion and transplantation cover a broad range of multidisciplinary studies, performed by many professionals involved in this most challenging clinical field [1]. This commentary on the current position and future perspectives in pediatric transfusion field is aimed to highlight major unresolved transfusion complications in pediatric patients, namely red blood cell and platelet alloimmunisation, and new ones such as nosocomial infection, thrombosis and multi-organ failure...
May 16, 2018: Transfusion and Apheresis Science
Jonghyuck Park, Joseph T Decker, Daniel J Margul, Dominique R Smith, Brian J Cummings, Aileen J Anderson, Lonnie D Shea
Trauma to the spinal cord and associated secondary inflammation can lead to permanent loss of sensory and motor function below the injury level, with the resulting environment serving as a barrier that limits regeneration. In this study, we investigate the localized expression of anti-inflammatory cytokines IL-10 and IL-4 via lentiviral transduction in multichannel bridges. Porous multichannel bridges provide physical guidance for axonal outgrowth with the cytokines hypothesized to modulate the neuroinflammatory microenvironment and enhance axonal regeneration...
April 27, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
A D Bounds, N C Jackson, R K Hanley, R Faoro, E M Bridge, P Huillery, M P A Jones
We propose and demonstrate the laser cooling and trapping of Rydberg-dressed Sr atoms. By off-resonantly coupling the excited state of a narrow (7 kHz) cooling transition to a high-lying Rydberg state, we transfer Rydberg properties such as enhanced electric polarizability to a stable magneto-optical trap operating at <1  μK. Simulations show that it is possible to reach a regime where the long-range interaction between Rydberg-dressed atoms becomes comparable to the kinetic energy, opening a route to combining laser cooling with tunable long-range interactions...
May 4, 2018: Physical Review Letters
S Trautmann, M Richard-Lacroix, A Dathe, H Schneidewind, J Dellith, W Fritzsche, V Deckert
The optical response of realistic 3D plasmonic substrates composed of randomly shaped particles of different size and interparticle distance distributions in addition to nanometer scale surface roughness is intrinsically challenging to simulate due to computational limitations. Here, we present a Finite Element Method (FEM)-based methodology that bridges in-depth theoretical investigations and experimental optical response of plasmonic substrates composed of such silver nanoparticles. Parametrized scanning electron microscopy (SEM) images of surface enhanced Raman spectroscopy (SERS) active substrate and tip-enhanced Raman spectroscopy (TERS) probes are used to simulate the far-and near-field optical response...
May 18, 2018: Nanoscale
Marina Suzuki, Nanae Shinozuka, Tomohiro Hirakata, Miyuki T Nakata, Taku Demura, Hirokazu Tsukaya, Gorou Horiguchi
Organ size regulation is dependent on the precise spatial and temporal regulation of cell proliferation and cell expansion. A number of transcription factors have been identified that play a key role in the determination of aerial lateral organ size, but their functional relationship to various chromatin modifiers has not been well understood. To understand how leaf size is regulated, we previously isolated the oligocellula1 ( oli1 ) mutant of Arabidopsis thaliana that develops smaller first leaves than the wild type (WT) mainly due to a reduction in the cell number...
2018: Frontiers in Plant Science
Satoshi Kamijo, Yuichiro Ishii, Shin-Ichiro Horigane, Kanzo Suzuki, Masamichi Ohkura, Junichi Nakai, Hajime Fujii, Sayaka Takemoto-Kimura, Haruhiko Bito
In spite of many association studies linking gene polymorphisms and mutations of L-type Voltage-Gated Ca2+ Channels (VGCC) in neurodevelopmental disorders, such as autism and schizophrenia, specific L-type VGCC roles during brain development remain unclear. Yet, calcium signaling has been shown to be essential for neurodevelopmental processes such as sculpting of neurites, functional wiring and fine tuning of growing networks. To bridge this gap, we performed submembraneous calcium imaging using a membrane-tethered genetically-encoded calcium indicator (GECI) Lck-G-CaMP7...
May 17, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Pavneet Singh, Kathryn King-Shier, Shane Sinclair
OBJECTIVE: To identify and describe the perspectives, experiences, importance, and impact of compassionate care among ethnically diverse population groups. METHODS: A systematic search of peer-reviewed research focused on compassionate care in ethnically diverse populations published between 1946 and 2017 was conducted. RESULTS: A total of 2296 abstracts were retrieved, out of which 23 articles met the inclusion criteria. Synthesis of the literature identified the perspectives, facilitators and barriers of compassion in healthcare within ethnic groups...
2018: PloS One
Shuhei Ogata, Naoto Goto, Shoya Sakurai, Ayumi Ishii, Miho Hatanaka, Koushi Yoshihara, Ryota Tanabe, Kyosuke Kayano, Ryo Magaribuchi, Kenta Goto, Miki Hasegawa
Five Eu complexes with long alkyl chain groups, abbreviated as EuLCx ("x" indicates the number of methylene groups: x = 8, 12, 14, 18, and 22), were synthesized to evaluate their structural and luminescence properties in chloroform. The mother helicate Eu complex, EuL, which has two bipyridine moieties bridged by an ethylenediamine, has been previously reported. A reduced form in which the azomethine groups of L also coordinated to the Eu ion, EuLH, was newly prepared. EuLH also adopts a helicate molecular structure based on single crystal X-ray structural analysis...
May 17, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Katsuhide Yutani, Yoshinori Matsuura, Hisashi Naitow, Yasumasa Joti
In order to elucidate features of the denatured state ensembles that exist in equilibrium with the native state under physiological conditions, we performed 1.4-μs molecular dynamics (MD) simulations at 400 K and 450 K using the monomer subunits of three CutA1 mutants from Escherichia coli: an SH-free mutant (Ec0SH) with denaturation temperature (Td ) = 85.6 °C, a hydrophobic mutant (Ec0VV) with Td  = 113.3 °C, and an ionic mutant (Ec0VV_6) with Td  = 136.8 °C. The occupancy of salt bridges by the six substituted charged residues in Ec0VV_6 was 140...
May 16, 2018: Scientific Reports
Deteng Zhang, Sai Wu, Jianyong Feng, Yiyuan Duan, Dongming Xing, Changyou Gao
The interplay of microstructures and biological cues is critical to regulate the behaviors of Schwann cells (SCs) in terms of cellular spatial arrangement and directional migration as well as neurite orientation for bridging the proximal and distal stumps of the injured peripheral nervous system. In this study, stripe micropatterns having ridges/grooves of width 20/20 and 20/40 μm were fabricated on the surface of maleimide-functionalized biodegradable poly(ester carbonate) (P(LLA-MTMC)) films by the polydimethylsiloxane mold-pressing method, respectively...
May 13, 2018: Acta Biomaterialia
Yiming Su, David Jassby, Shikun Song, Xuefei Zhou, Hongying Zhao, Jan Filip, Eleni Petala, Yalei Zhang
Sulfidation of nanoscale zerovalent iron (nZVI) has shown some fundamental improvements on reactivity and selectivity towards pollutants in dissolved oxygen (DO) stimulated Fenton-like reaction systems (DO/S-nZVI system). However, the pristine micro-structure of sulfide modified nanoscale zerovalent iron (S-nZVI) remains uncovered. In addition, the relationship between pollutant removal and the oxidation of the S-nZVI is largely unknown. The present study confirms that sulfidation not only imparts sulfide and sulfate groups onto the surface of the nanoparticle (both on the oxide shell and on flake-like structures), but also introduces sulfur into the Fe(0) core region...
May 16, 2018: Environmental Science & Technology
Jiwei Luo, Xue Li, Chengjun Ge, Karin Müller, Huamei Yu, Peng Huang, Jiatong Li, Daniel C W Tsang, Nanthi S Bolan, Jörg Rinklebe, Hailong Wang
Pollution of water by single antibiotics has been investigated in depth. However, in reality, a wide range of different contaminants is often mixed in the aquatic environment (contaminant cocktail). Here, single and competitive sorption dynamics of ionizable norfloxacin (NOR), sulfamerazine (SMR) and oxytetracycline (OTC) by both pristine and modified biochars were investigated. Sorption kinetics of the three antibiotics was faster in ternary-solute than single-solute system. Sorption efficiency was enhanced in the competitive system for NOR by the pristine biochar, and for OTC by both the pristine biochar and the modified biochar, while SMR sorption by the pristine biochar and the KOH-modified biochar was inhibited...
May 8, 2018: Bioresource Technology
Yang Yang, Jiacheng Wang, Han Xu, Xiaowei Zhan, Xingguo Chen
In this work, a kind of "D-A (Donor-Acceptor) combined pi-bridge" based on the regioselective reactivity of monofluoro-substituted benzothiadiazole (FBT) to link a thiophene ring has been designed to construct a new A-pi-D-pi-A type small molecular acceptor (IDT-FBTR) with indacenodithienothiophene (IDT) as a central core (D) and 3-octyl-2-(1,1-dicyanomethylene)rhodanine as an electron-withdrawing terminal group (A). Due to the strong intramolecular push-pull electron effect, IDT-FBTR shows a strong and broad intramolecular charge transfer (ICT) absorption band in the range of 500-750 nm...
May 15, 2018: ACS Applied Materials & Interfaces
Yan-Ling Wang, Quan-Song Li, Ze-Sheng Li
Acceptor-π-donor-π-acceptor (A-π-D-π-A)-types of small molecules are very promising nonfullerene acceptors to overcome the drawbacks of fullerene derivatives such as the weak absorption ability and electronic adjustability. However, only few attempts have been made to develop π-bridge units to construct highly efficient acceptors in OSCs. Herein, taking the reported acceptor P1 as a reference, five small-structured acceptors (P2, P3, P4, P5, and P6) have been designed via the replacement of the π-bridge unit...
May 15, 2018: Physical Chemistry Chemical Physics: PCCP
Raphael K Sung, Penelope A Boyden, Melvin Scheinman
Fascicular ventricular arrhythmias represent a spectrum of ventricular tachycardias dependent on the specialized conduction system. Although they are more common in structurally abnormal hearts, there is an increasing body of literature describing their role in normal hearts. In this review, the authors present data from both basic and clinical research that explore the current understanding of idiopathic fascicular ventricular arrhythmias. Evaluation of the cellular electrophysiology of the Purkinje cells shows clear evidence of enhanced automaticity and triggered activity as potential mechanisms of arrhythmias...
December 11, 2017: JACC. Clinical Electrophysiology
Jingchao Wang, Danrui Cui, Shanshan Gu, Xiaoyu Chen, Yanli Bi, Xiufang Xiong, Yongchao Zhao
Apoptosis and autophagy mutually regulate various cellular physiological and pathological processes. The crosstalk between autophagy and apoptosis is multifaceted and complicated. Elucidating the molecular mechanism of their crosstalk will advance the therapeutic applications of autophagy for treating cancer and other diseases. NOXA, a BH3-only member of the BCL-2 family, was reported to induce apoptosis and promote autophagy. Here, we report that autophagy regulates apoptosis by targeting NOXA for degradation...
May 11, 2018: Biochimica et Biophysica Acta
Barbara Wise, Terie Dreussi-Smith
BACKGROUND AND PURPOSE: There is a much recent emphasis on the social determinants of health, and poverty is the most influential of these. It is not enough merely to understand the influence of poverty on health-the primary care provider must understand how to effectively treat patients who live in poverty. METHODS: This article applies the Bridges to Health and Healthcare model for understanding poverty to primary care practice from an individual provider's perspective...
April 2018: Journal of the American Association of Nurse Practitioners
Wenjie Jing, Yuexiang Lu, Feiyang Wang, Liuying He, Jingwei Sun, Yueying Liu
A time-resolved phosphorescence (TRP) is applied to the highly sensitive determination of Fe(II) ions. The method is based on the use of a phosphorescent probe consisting of cysteine-bridged Mn-doped ZnS quantum dots (Mn/ZnS QDs). The presence of cysteine enhances the phosphorescence of the QDs and also increases the efficiency of quenching caused by Fe(II) ions. This results in strongly improved selectivity for Fe(II). The linear response is obtained in the concentration range of 50-1000 nM with a 19 nM detection limit...
May 12, 2018: Mikrochimica Acta
Matheus Hausen, Pedro Paulo Soares, Marcus Paulo Araujo, Débora Esteves, Hilbert Julio, Roberto Tauil, Marcus Junca, Flávia Porto, Emerson Franchini, Craig Alan Bridge, Jonas Gurgel
PURPOSE: The purpose of the present study was to propose and validate new taekwondo-specific cardiopulmonary exercise tests. METHODS: Twelve male national-level taekwondo athletes (age 20 ± 2 yrs; body mass 67.5 ± 5.7 kg; height 175 ± 8 cm; training experience 7 ± 3 yrs) performed three separate exercise tests in a randomized counterbalanced order: 1) a Treadmill Running Cardiopulmonary Exercise Test (CPET); 2) Continuous and 3) Interval Taekwondo Cardiopulmonary Exercise Tests (cTKDet and iTKDet, respectively)...
May 10, 2018: International Journal of Sports Physiology and Performance
Jinyang Jiang, Yiru Yan, Dongshuai Hou, Jiao Yu
In this paper, first principles and reactive force field molecular dynamics were utilized to study the mechanical properties of tobermorite 9 Å, tobermorite 11 Å and jennite. These are essential minerals in cement chemistry. The mechanical properties calculated by the first-principle method match well with previous experimental results, pointing to the introduction of vdW dispersion-type forces as able to improve the precision. The calculated elastic constants of the three minerals confirm anisotropic mechanical behavior of the layered structures...
May 10, 2018: Physical Chemistry Chemical Physics: PCCP
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