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Serous cystadenoma

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https://www.readbyqxmd.com/read/28730785/pdcd1-strengthens-the-sensitivity-of-ovarian-cancer-to-cisplatin-chemotherapy-by-promoting-apoptosis
#1
Qian Li, Jie-Fan Gao, Bing-Li Qi
PURPOSE: The primary purpose of this study was to make clear the role of PDCD1 in the occurrence and progression of ovarian cancer, and explain its mechanism. METHODS: RT-PCR, westem blot, MTT and immunohistochemistry were used to detect the expression levels of PDCD1 mRNA and protein in human ovarian cancer cell lines (SKOV3, 3AO, CAOV3 and OVCAR3), human normal ovary, serous cystadenoma, and serous cystadenocarcinoma tissue. SKOV3, SKOV3-MOCK, and SKOV3-PDCD1 cells were subcutaneously injected into the armpit of nude mice to observe the effect of PDCD1 expression on tumorigenic ability...
May 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28700429/mucosal-proliferations-in-completely-examined-fallopian-tubes-accompanying-ovarian-low-grade-serous-tumors-neoplastic-precursor-lesions-or-normal-variants-of-benign-mucosa
#2
Rebecca J Wolsky, Matt A Price, Charles J Zaloudek, Joseph T Rabban
Malignant transformation of the fallopian tube mucosa, followed by exfoliation of malignant cells onto ovarian and/or peritoneal surfaces, has been implicated as the origin of most pelvic high-grade serous carcinoma. Whether a parallel pathway exists for pelvic low-grade serous tumors [ovarian serous borderline tumor (SBT) and low-grade serous carcinoma (LGSC)] remains to be fully elucidated. The literature is challenging to interpret due to variation in the diagnostic criteria and terminology for cytologically low-grade proliferations of the fallopian tube mucosa, as well as variation in fallopian tube specimen sampling...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28697137/clinical-profile-of-pancreatic-cystic-lesions-in-von-hippel-lindau-disease-a-series-of-48-patients-seen-at-a-tertiary-institution
#3
Ayush Sharma, Saurabh Mukewar, Santhi Swaroop Vege
OBJECTIVES: Little is known about the association between pancreatic cystic lesions (PCLs) with von Hippel-Lindau disease (VHLD). In this study, we describe the clinical presentation, type of PCLs, and risk for malignancy in PCLs in VHLD. METHODS: Patients given a diagnosis of both VHLD and PCLs were identified from electronic medical records at Mayo Clinic, Rochester, MN, from January 1, 2000, to January 1, 2016. Various demographic, clinical, and radiologic variables were recorded...
August 2017: Pancreas
https://www.readbyqxmd.com/read/28673874/post-operative-outcomes-after-single-port-laparoscopic-removal-of-adnexal-masses-in-patients-referred-to-gynecologic-oncology-at-a-large-academic-center
#4
Laura J Moulton, Amelia M Jernigan, Chad M Michener
OBJECTIVE: To report surgical and pathologic outcomes after single port laparoscopy (SPL) for adnexal masses in patients referred to a gynecologic oncology practice at a single academic institution. DESIGN: Retrospective analysis (Canadian Task Force Classification II.2). SETTING: A single academic institution with multiple hospital centers PATIENTS: Women who underwent at least one single port laparoscopic surgery for treatment of an adnexal mass from 2009-2015 after referral to a gynecologic oncology practice...
June 30, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28609361/pancreatic-cysts-part-2-should-we-be-less-cyst-centric
#5
Anne Marie Lennon, Marcia Irene Canto
The management of pancreatic cysts is a common problem faced by physicians and surgeons. Pancreatic cysts are important because some of them are mucin-producing cysts (MPCs), which may harbor or develop pancreatic ductal adenocarcinoma. Thus, accurate classification of pancreatic cysts and diagnosis of MPCs offer a potential for the prevention or early detection of pancreatic cancer. However, the diagnosis and management of asymptomatic pancreatic cysts are complicated by 2 factors. First, incidentally detected pancreatic cysts are often misdiagnosed as branch duct intraductal papillary mucinous neoplasms...
July 2017: Pancreas
https://www.readbyqxmd.com/read/28566895/in-vivo-and-ex-vivo-confocal-endomicroscopy-of-pancreatic-cystic-lesions-a-prospective-study
#6
Somashekar G Krishna, Rohan M Modi, Amrit K Kamboj, Benjamin J Swanson, Phil A Hart, Mary E Dillhoff, Andrei Manilchuk, Carl R Schmidt, Darwin L Conwell
AIM: To investigate the reproducibility of the in vivo endoscopic ultrasound (EUS) - guided needle based confocal endomicroscopy (nCLE) image patterns in an ex vivo setting and compare these to surgical histopathology for characterizing pancreatic cystic lesions (PCLs). METHODS: In a prospective study evaluating EUS-nCLE for evaluation of PCLs, 10 subjects underwent an in vivo nCLE (AQ-Flex nCLE miniprobe; Cellvizio, MaunaKea, Paris, France) during EUS and ex vivo probe based CLE (pCLE) of the PCL (Gastroflex ultrahigh definition probe, Cellvizio) after surgical resection...
May 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28528374/pancreatic-cysts-and-guidelines
#7
REVIEW
James J Farrell
Pancreatic cysts, especially incidental asymptomatic ones seen on noninvasive imaging such as CT or MR imaging, remain a clinical challenge. The etiology of such cysts may range from benign cysts without any malignant potential such as pancreatic pseudocysts and serous cystadenomas to premalignant or frankly malignant cysts such as mucinous cystic neoplasms, intraductal papillary mucinous neoplasms, cystic degeneration associated with solid tumors such as pancreatic ductal adenocarcinoma or pancreatic endocrine neoplasms, and solid pseudopapillary neoplasms...
July 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28525201/-macrocystic-serous-cystadenoma-of-the-pancreas-about-a-case
#8
H Adamou, I Amadou Magagi, O Adakal, O Habou, T Tchindo, L Kolle, A Illo
Serous cystadenomas of pancreas are unusual cystic tumour. The microcystic forms is more common and its radiological diagnosis is easy. However, the macrocystic unilocular form of serous cystadenoma can be mistaken with other malignant macrocystic lesions of the pancreas. We report the case of a 17 year-old girl, admitted to the National Hospital of Niamey (Niger), with abdominal pain and an unilocular macrocystic serous cystadenoma of pancreas, diagnosed after histological examination of the surgical specimen...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28522787/surgical-treatment-of-pancreatic-cystic-tumors
#9
Beata Jabłońska, Łukasz Braszczok, Weronika Szczęsny-Karczewska, Beata Dubiel-Braszczok, Paweł Lampe
The aim of this study was to assess short-term outcomes of surgical treatment of pancreatic cystic tumors (PCTs). MATERIAL AND METHODS: We retrospectively reviewed medical records of 46 patients (31 women and 15 men) who had undergone surgery for pancreatic cystic tumors in our department. RESULTS: Pancreatic cystic tumors were located within the pancreatic head (21), body (11), tail (13), and whole pancreas (1). The following surgical procedures were performed: pancreatoduodenectomy (20), central pancreatectomy (9), distal pancreatectomy (3), distal pancreatectomy with splenectomy (3), distal extended pancreatectomy with splenectomy (2), total pancreatectomy (1), duodenum preserving pancreatic head resection (1), local tumor resection (4), and other procedures (2)...
February 28, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28507579/assessment-of-concentrations-of-strail-ligand-and-its-receptors-strail-r1-and-strail-r2-markers-monitoring-the-course-of-the-extrinsic-pathway-of-apoptosis-induction-potential-application-in-ovarian-cancer-diagnostics
#10
Aleksandra Mielczarek-Palacz, Justyna Sikora, Zdzisława Kondera-Anasz
INTRODUCTION: TNF-related apoptosis-inducing ligand (TRAIL) together with its receptors are involved in activation of the extrinsic pathway of apoptosis. Due to the special role of the apoptosis pathway in pathogenesis of ovarian cancers, the aim of the study was to assess concentrations of sTRAIL, sTRAIL-R1 and sTRAIL-R2 in serum of affected women. MATERIAL AND METHODS: The study group included 85 women with diagnosed ovarian tumors: 35 women with ovarian serous cystadenoma, 15 women with ovarian teratoma and 35 women with serous cystadenocarcinoma...
April 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28503633/reactive-oxygen-species-and-serous-epithelial-ovarian-adenocarcinoma
#11
Shakeria Cohen, Sharifeh Mehrabi, Xuebiao Yao, Stephanie Millingen, Felix O Aikhionbare
Serous ovarian cancer (SOC) is usually diagnosed at late stage and stage-adjusted five year survival rate is low. Mortality is relatively heavy on African-Americans/Black (AA) affected with SOC compared to their Caucasian counterparts, though the cause for the disparity remains unclear. DNA damage induced by oxidative stress has been linked to ovarian cancer, but the role of oxidative stress in distinguishing differences in aggressive SOC tumors among patients is yet to be determined. This study aims to determine the levels of reactive oxygen species (ROS), malondialdehyde (MDA), reactive carbonyl groups and antioxidants in primary SOC normal, precancerous (cystadenoma, borderline) and invasive (III/IV) tissue samples obtained from AA and Caucasian subgroups...
November 2016: Cancer research journal
https://www.readbyqxmd.com/read/28491011/an-integrated-proteomic-and-glycoproteomic-approach-uncovers-differences-in-glycosylation-occupancy-from-benign-and-malignant-epithelial-ovarian-tumors
#12
Qing Kay Li, Punit Shah, Yuan Tian, Yingwei Hu, Richard B S Roden, Hui Zhang, Daniel W Chan
BACKGROUND: Epithelial ovarian carcinomas encompass a heterogeneous group of diseases with a poor 5-year survival rate. Serous carcinoma is the most common type. Most FDA-approved serum tumor markers are glycoproteins. These glycoproteins on cell surface or shed into the bloodstream could serve as therapeutic targets as well as surrogates of tumor. In addition to glycoprotein expressions, the analysis of protein glycosylation occupancy could be important for the understanding of cancer biology as well as the identification of potential glycoprotein changes in cancer...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28488545/determination-of-braf-v600e-ve1-protein-expression-and-braf-gene-mutation-status-in-codon-600-in-borderline-and-low-grade-ovarian-cancers
#13
Pawel Sadlecki, Pawel Walentowicz, Magdalena Bodnar, Andrzej Marszalek, Marek Grabiec, Malgorzata Walentowicz-Sadlecka
Epithelial ovarian tumors are a group of morphologically and genetically heterogeneous neoplasms. Based on differences in clinical phenotype and genetic background, ovarian neoplasms are classified as low-grade and high-grade tumor. Borderline ovarian tumors represent approximately 10%-20% of all epithelial ovarian masses. Various histological subtypes of ovarian malignancies differ in terms of their risk factor profiles, precursor lesions, clinical course, patterns of spread, molecular genetics, response to conventional chemotherapy, and prognosis...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28464579/-clinical-study-on-the-relationship-between-pancreatic-fistula-and-the-degree-of-pancreatic-fibrosis-after-pancreatic-and-duodenal-resection
#14
M W Yang, Y Deng, T Huang, L D Zhang
Objective: To explore the risk factors of pancreatic fistula after pancreatoduodenectomy and its relationship with pancreatic fibrosis. Methods: Retrospective analysis was made including 408 patients who underwent pancreaticoduodenectomy from January 2013 to December 2015 in Department of Hepatobiliary Surgery of the First Affiliated Hospital of Third Military Medical University. There were 274 males and females, aging from 14 to 82 years with an average age of 54.6 years. Postoperative pathological diagnosis: 285 cases with pancreatic ductal adenocarcinoma, 81 cases with gastrointestinal tumors, 13 cases with neuroendocrine tumors, 16 cases with inflammatory changes, 8 cases with pancreatic papillary tumors, 4 cases with serous cystadenoma, 1 case with retroperitoneal liposarcoma...
May 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28444494/imaging-of-pancreatic-cystic-lesions-with-confocal-laser-endomicroscopy-an-ex-vivo-pilot-study
#15
Abdurrahman Kadayifci, Mustafa Atar, Michelle Yang, Carlos Fernandez-Del Castillo, Mari Mino-Kenudson, William R Brugge
BACKGROUND: The differential diagnosis of pancreatic cystic lesions (PCLs) is an increasingly common clinical challenge. Confocal laser endomicroscopy (CLE) may differentiate PCLs by imaging of the cyst wall. However, clinical experience is still limited, and better image definition and characterization of the cyst wall in a spectrum of cysts are needed. This experimental study aimed to expose detailed imaging characteristics of PCLs by CLE. METHODS: Patients who underwent surgery of a PCL were enrolled...
April 25, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28421458/surgical-management-of-pancreatic-cysts-a-shifting-paradigm-toward-selective-resection
#16
REVIEW
Jon M Gerry, George A Poultsides
Due to the widespread use of high-quality cross-sectional imaging, pancreatic cystic neoplasms are being diagnosed with increasing frequency. Clinicians are therefore asked to counsel a growing number of patients with pancreatic cysts diagnosed incidentally at an early, asymptomatic stage. Over the last two decades, accumulating knowledge on the biologic behavior of these neoplasms along with improved diagnostics through imaging and endoscopic cyst fluid analysis have allowed for a selective therapeutic approach toward these neoplasms...
July 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28414765/validation-of-full-field-optical-coherence-tomography-in-distinguishing-malignant-and-benign-tissue-in-resected-pancreatic-cancer-specimens
#17
Labrinus van Manen, Paulien L Stegehuis, Arantza Fariña-Sarasqueta, Lorraine M de Haan, Jeroen Eggermont, Bert A Bonsing, Hans Morreau, Boudewijn P F Lelieveldt, Cornelis J H van de Velde, Alexander L Vahrmeijer, Jouke Dijkstra, J Sven D Mieog
BACKGROUND: Pancreatic cancer is the fourth leading cause of cancer-related mortality in the United States. The minority of patients can undergo curative-intended surgical therapy due to progressive disease stage at time of diagnosis. Nonetheless, tumor involvement of surgical margins is seen in up to 70% of resections, being a strong negative prognostic factor. Real-time intraoperative imaging modalities may aid surgeons to obtain tumor-free resection margins. Full-field optical coherence tomography (FF-OCT) is a promising diagnostic tool using high-resolution white-light interference microscopy without tissue processing...
2017: PloS One
https://www.readbyqxmd.com/read/28408339/a-retroperitoneal-serous-cystadenoma-of-m%C3%A3-llerian-origin-masquerading-as-a-massive-renal-cyst
#18
Vikram K Sabarwal, Aaditya Chandrasekar, Joshua Engel, Antoun Toubaji, Jason D Engel
A 78-year-old woman presented to the urology clinic with a large, symptomatic left-sided abdominal cyst that was believed to be renal in etiology for many years and that had been percutaneously drained 3 times previously with persistent regrowth. The patient underwent laparoscopic resection of this mass, which proved to be a completely distinct retroperitoneal cystic structure and was not renal in nature. Pathologic analysis ultimately revealed a rare occurrence: a benign retroperitoneal Müllerian serous cystadenoma...
April 10, 2017: Urology
https://www.readbyqxmd.com/read/28404017/dna-testing-of-pancreatic-cyst-fluid-is-it-ready-for-prime-time
#19
REVIEW
Aatur D Singhi, Marina N Nikiforova, Kevin McGrath
Pancreatic cysts are a clinical quandary in both diagnosis and management. Although many cysts, such as pseudocysts and serous cystadenomas, are benign and can be monitored clinically, mucinous cysts, such as intraductal papillary mucinous neoplasms and mucinous cystic neoplasms, have the potential to progress to pancreatic cancer. Considering the poor prognosis of pancreatic cancer, the detection of a pancreatic cyst can be a source of anxiety for both the patient and physician. This diagnosis in turn can lead to expensive, invasive, and even harmful surveillance and treatment options...
January 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28325663/serous-cystadenoma-of-the-retroperitoneum
#20
Krystel Paris, Catherine Anku-Bertholet, Sandeep Mayer
No abstract text is available yet for this article.
June 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
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