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Benign neoplasms in women

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https://www.readbyqxmd.com/read/27874206/spitz-nevi-and-other-spitzoid-neoplasms-in-children-overview-of-incidence-data-and-diagnostic-criteria
#1
REVIEW
Emi Dika, Giulia Maria Ravaioli, Pier Alessandro Fanti, Iria Neri, Annalisa Patrizi
Spitz nevi are benign melanocytic neoplasms characterized by epithelioid or spindle melanocytes or both. In some rare cases their presentation overlaps with the clinical and histopathologic features of malignant melanoma, so a differential diagnosis can be difficult to make. Intermediate forms between Spitz nevi and malignant melanoma, with unpredictable behavior, have been called atypical Spitz tumors. A literature search was performed to review the clinical, dermoscopic, genetic, and histopathologic aspects of spitzoid tumors...
November 22, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27858099/-percutaneous-embolization-and-ultrasound-scissors-for-removal-of-a-carotid-body-tumor
#2
I I Venara-Vulpe, B Morisod, G B Morand, J-B Zerlauth, C Simon
Paragangliomas are highly vascularized usually benign neoplasms originating from the sympathoadrenal and parasympathetic paraganglia of the autonomic nervous system. When resectable, the management of these tumors consists of surgical ablation preceded by transarterial embolization. The aim of this article is to describe a novel treatment strategy combining intralesional percutaneous embolization with dissection using ultrasound scissors. The case of a 74-year-old women presenting with a Shamblin type III carotid body paraganglioma is presented...
December 2016: HNO
https://www.readbyqxmd.com/read/27816717/pancreatic-serous-cystic-neoplasms-accompanying-other-pancreatic-tumors
#3
So-Woon Kim, In Hye Song, Soyeon An, So Yeon Kim, Hyoung Jung Kim, Ki-Byung Song, Dae Wook Hwang, Sang Soo Lee, Jae Ho Byun, Dong-Wan Seo, Song Cheol Kim, Eunsil Yu, Seung-Mo Hong
Serous cystic neoplasms (SCNs) are benign cystic neoplasms that predominantly occur in the tail of the pancreas in elderly women. It is well known that patients with von Hippel-Lindau syndrome can develop SCNs and neuroendocrine tumors in the pancreas. However, our understanding on SCNs accompanying other pancreatic tumors (SCNAOPTs) is limited. We compared the clinicopathologic features of 15 surgically resected SCNAOPTs with 259 conventional SCNs. The prevalence of SCNAOPT was 5%. The SCNAOPTs were significantly smaller than conventional solitary SCNs, and they were more commonly observed in the head of the pancreas, while conventional solitary SCNs were more frequently noted in the body and tail...
November 2, 2016: Human Pathology
https://www.readbyqxmd.com/read/27806841/diagnostic-pitfalls-of-infarcted-warthin-tumor-in-frozen-section-evaluation
#4
Yaohong Tan, Oleksandr N Kryvenko, Darcy A Kerr, Jennifer R Chapman, Christina Kovacs, David J Arnold, Andrew E Rosenberg, Carmen R Gomez-Fernandez
Warthin tumor (WT) is the second most common benign salivary gland neoplasm and has characteristic cytologic and histologic findings. Fine-needle aspiration is a common and useful preoperative diagnostic technique, which sometimes leads to ischemic injury resulting in the infarction of these lesions. Infarcted WT may demonstrate variable gross and histologic alterations that may render the diagnosis challenging, particularly during intraoperative frozen section evaluation. In this study, we collected 11 resection specimens from 9 patients with infarcted WT...
December 2016: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/27804932/-mucinous-cystic-liver-tumors-diagnosis-and-surgical-treatment
#5
P V Usyaky, V A Kubyshkin, V A Vishnevsky, Yu A Kovalenko, N A Karel'skaya, D V Kalinin, V S Demidova, A V Varlamov
AIM: To optimize diagnostics and treatment of cystic liver tumors. MATERIAL AND METHODS: The analysis included outcomes of 46 patients with liver cystic tumors. RESULTS AND DISCUSSION: The use of abdominal Doppler-sonography (37 patients), abdominal contrast-enhanced CT (44 patients) and MRI of abdominal cavity with MR-cholangiography (24 patients) defined radiological semiotics of cystic liver diseases. The most important features of cystic tumors are intraluminal septums with blood flow (82% of patients), solid component (6...
2016: Khirurgiia
https://www.readbyqxmd.com/read/27770388/risk-of-malignant-neoplasms-in-acromegaly-a-case-control-study
#6
K Wolinski, A Stangierski, K Dyrda, K Nowicka, M Pelka, A Iqbal, A Car, M Lazizi, N Bednarek, A Czarnywojtek, E Gurgul, M Ruchala
PURPOSE: Acromegaly is a chronic disease resulting from pathological oversecretion of growth hormone and subsequently insulin growth factor-1. Several complications of the disease have been reported, including cardiovascular diseases, respiratory disorders but also increased risk of benign and malignant neoplasms. The aim of the study was to evaluate the risk of malignant neoplasms in the patients with acromegaly in comparison with the control group. PATIENTS AND METHODS: Medical documentation of acromegalic patients treated in one medical center between 2005 and 2016 has been analyzed...
October 21, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27759594/the-association-of-peripheral-blood-regulatory-t-cell-concentrations-with-epithelial-ovarian-cancer-a-brief-report
#7
Rikki A Cannioto, Lara E Sucheston-Campbell, Shalaka Hampras, Ellen L Goode, Keith Knutson, Roberta Ness, Francesmary Modugno, Paul K Wallace, J Brian Szender, Paul Mayor, Chi-Chen Hong, Janine M Joseph, Grace Friel, Warren Davis, Mary Nesline, Kevin H Eng, Robert P Edwards, Bridget Kruszka, Kristina Schmitt, Kunle Odunsi, Kirsten B Moysich
OBJECTIVE: There is a mounting body of evidence demonstrating higher percentages of regulatory T (Treg) cells in the peripheral blood of patients with cancer in comparison to healthy controls, but there is a paucity of epidemiological literature characterizing circulating Treg cells among patients with epithelial ovarian cancer (EOC). To investigate the role of peripheral Treg cells in ovarian neoplasms, we conducted a case-control study to characterize circulating concentrations of Treg cells among patients with EOC, women with benign ovarian conditions, and healthy controls without a history of cancer...
October 18, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27741335/adalimumab-treatment-in-women-with-moderate-to-severe-hidradenitis-suppurativa-from-the-placebo-controlled-portion-of-a-phase-2-randomized-double-blind-study
#8
Alice Gottlieb, Alan Menter, April Armstrong, Christopher Ocampo, Yihua Gu, Henrique D Teixeira
BACKGROUND: Hidradenitis Suppurativa (HS), also known as acne inversa, is a painful, chronic, debilitating, inflammatory skin disease and has shown response to anti-TNF-α therapy. Efficacy and safety of the anti-TNF-α agent, adalimumab, was assessed in a post hoc analysis of women from the first 16 weeks of a phase 2 study of men and women with HS. METHODS: Patients with moderate-to-severe HS in at least 2 body areas, unresponsive or intolerant to oral antibiotics for treatment of their HS, and with no previous anti-TNF-a or systemic non-biologic treatment, were randomized 1:1:1 to 40 mg adalimumab-weekly or every-other-week, or placebo...
October 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27733937/a-rare-case-of-pancreatic-endometriosis-in-a-postmenopausal-woman-and-review-of-the-literature
#9
Verena Plodeck, Ulrich Sommer, Gustavo B Baretton, Daniela E Aust, Michael Laniado, Ralf-Thorsten Hoffmann, Ivan Platzek
Pancreatic endometriosis is very rare with only a few cases reported in the literature. The imaging features are non-specific and the definitive diagnosis is usually only established after surgery. We report on a 68-year-old woman with left upper quadrant pain who demonstrated a mass in the pancreatic tail on imaging. Laboratory results showed only mildly elevated liver enzymes, tumor markers were within the normal range. A left pancreatectomy was performed, frozen section suggesting a benign lesion, and final histopathology confirmed endometriotic cysts...
September 2016: Acta Radiologica Open
https://www.readbyqxmd.com/read/27686175/spindle-cell-lipomas-arising-at-atypical-locations
#10
Nasir Ud Din, Pingchuan Zhang, William R Sukov, Christopher A Sattler, Sarah M Jenkins, Leona A Doyle, Andrew L Folpe, Karen J Fritchie
OBJECTIVES: Spindle cell lipomas (SCLs) are benign lipomatous neoplasms that classically arise in the posterior neck, upper back, and shoulders of older male patients. We sought to characterize the occurrence of this entity at nonclassic sites. METHODS: All cases of SCL arising at atypical sites were retrieved from our archives. RESULTS: Of 439 total cases of SCL, 57 arose at atypical locations in 32 men and 25 women (age range, 27-79 years)...
October 2016: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27681503/nature-and-management-of-pancreatic-mucinous-cystic-neoplasm-mcn-a-systematic-review-of-the-literature
#11
Linda N Nilsson, Margaret G Keane, Awad Shamali, Judith Millastre Bocos, Monica Marijinissen van Zanten, Anne Antila, Cristina Verdejo Gil, Marco Del Chiaro, Johanna Laukkarinen
BACKGROUND: The current management of pancreatic mucinous cystic neoplasms (MCN) is defined by the consensus European, International Association of Pancreatology and American College of Gastroenterology guidelines. However, the criterion for surgical resection remains uncertain and differs between these guidelines. Therefore through this systematic review of the existing literature we aimed to better define the natural history and prognosis of these lesions, in order to clarify recommendations for future management...
September 20, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27668074/clinical-relevance-of-aberrant-polypoid-nodule-scar-after-endoscopic-submucosal-dissection
#12
Vitor Arantes, Noriya Uedo, Moises Salgado Pedrosa, Yasuhiko Tomita
AIM: To describe a series of patients with aberrant polypoid nodule scar developed after gastric endoscopic submucosal dissection (ESD), and to discuss its pathogenesis and clinical management. METHODS: We reviewed retrospectively the endoscopic database of two academic institutions located in Brazil and Japan and searched for all patients that underwent ESD to manage gastric neoplasms from 2003 to 2015. The criteria for admission in the study were: (1) successful en bloc ESD procedure with R0 and curative resection confirmed histologically; (2) postoperative endoscopic examination with identification of a polypoid nodule scar (PNS) at ESD scar; (3) biopsies of the PNS with hyperplastic or regenerative tissue, reviewed by two independent experienced gastrointestinal pathologists, one from each Institution...
September 16, 2016: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27635945/myolipoma-of-soft-tissue-clinicopathologic-analysis-of-34-cases
#13
Mana Fukushima, Inga-Marie Schaefer, Christopher D M Fletcher
Myolipoma of soft tissue, which was first described by Meis and Enzinger (1991), is a rare benign neoplasm characterized by the admixture of mature adipocytes and well-differentiated smooth muscle cells. Recently, cytogenetic alteration of the HMGA2 gene has been reported in 2 myolipomas. We present the clinicopathologic features of 34 cases of myolipoma of soft tissue, study immunoreactivity for HMGA2, and review the previous literature. In our series, there were 32 women and 2 men, with age at presentation ranging from 35 to 94 years (median, 55 y)...
September 15, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27617531/angioqueratomas-de-fordyce-m%C3%A3%C2%BAltiplos-de-vulva-associados-%C3%A3-cirrose-hep%C3%A3-tica
#14
Marcelo Souza Teixeira, Caren Dos Santos Lima, Simone De Abreu Neves Salles1, Flávio Barbosa Luz, Roberta Roberta Duarte Bezerra Pinto, Luciana Pantaleão
Fordyce angiokeratoma is a benign skin neoplasm, characterized by erythematous-violet keratotic papules with mamillated surface, which follows a chronic and minimally symptomatic course. However, symptoms can be related such as itching, burning, bleeding, dyspareunia; aesthetic and social concerns may prompt request for treatment. The condition mainly affects men and usually occurs in the scrotum, but rarely may occur in women. A 30-year-old woman with liver cirrhosis and portal hypertension is described. Over a period of two years she developed multiple angiokeratomas of the vulva, complicated by frequent bleeding...
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27552403/prevalence-of-appendiceal-lesions-in-appendicectomies-performed-during-surgery-for-mucinous-ovarian-tumors-a-retrospective-study
#15
Luiza Moore, Ketan Gajjar, Mercedes Jimenez-Linan, Robin Crawford
OBJECTIVES: The aim of this study was to assess the frequency of appendiceal pathology in women undergoing surgery for mucinous ovarian neoplasm and to evaluate whether appendicectomy is necessary. METHODS: This single-institution retrospective study reviewed prevalence of appendiceal lesions in all patients operated on at our institution from 2002 to 2013 with the final diagnosis of mucinous tumor of the ovary. Clinicopathological data were analyzed. RESULTS: One hundred twenty-three cases were identified...
October 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27539223/bcl9l-expression-in-pancreatic-neoplasia-with-a-focus-on-spn-a-possible-explanation-for-the-enigma-of-the-benign-neoplasia
#16
Cora Hallas, Julia Phillipp, Lukas Domanowsky, Bettina Kah, Katharina Tiemann
BACKGROUND: Solid pseudopapillary neoplasms of the pancreas (SPN) are rare tumors affecting mainly women. They show an activating mutation in CTNNB1, the gene for β-catenin, and consequently an overactivation of the Wnt/β-catenin pathway. This signaling pathway is implied in the pathogenesis of various aggressive tumors, including pancreatic adenocarcinomas (PDAC). Despite this, SPN are characterized by an unusually benign clinical course. Attempts to explain this lack of malignancy have led to the discovery of an aberrant expression of the transcription factor FLI1 in SPN...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27530410/microrna-15b-regulates-reversion-inducing-cysteine-rich-protein-with-kazal-motifs-reck-expression-in-human-uterine-leiomyoma
#17
Yichun Guan, Lankai Guo, Lawrence Zukerberg, Bo R Rueda, Aaron K Styer
BACKGROUND: Human uterine leiomyoma (fibroids; LYO) are the most common benign neoplasms in reproductive-aged women. Dysregulated extracellular matrix and irregular LYO reversion-inducing cysteine-rich protein with Kazal motifs (RECK) expression are thought to be mediated by aberrant microRNA (miR) expression. The relationship of miR-15b and RECK expression in LYO has not been studied. METHODS: The expression levels of miR-15b and RECK were determined by quantitative RT-PCR, Western blot, and immunohistochemistry in cultures derived from commercial primary leiomyoma (cpLYO) and myometrial (cpMYO) cell lines and leiomyoma (pLYO) and myometrium (pMYO) tissue from surgical samples respectively...
2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27526296/polyclonality-in-sclerosing-angiomatoid-nodular-transformation-of-the-spleen
#18
Kung-Chao Chang, Jen-Chieh Lee, Yu-Chu Wang, Liang-Yi Hung, Yenlin Huang, Wan-Ting Huang, Ren-Ching Wang, Tse-Ching Chen, Yi-Shan Tsai, L Jeffrey Medeiros
Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a morphologically distinctive lesion. Although the clinical course of SANT is benign, its reactive or neoplastic nature remains to be clarified. Furthermore, some investigators have suggested that SANT is related to IgG4 sclerosing lesion or inflammatory pseudotumor with stromal cells positive for Epstein-Barr virus (EBV). In this study, we assessed 22 cases of SANT derived from adult women. Clinical data and follow-up information were obtained by chart review...
October 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27512342/cytokines-and-prognostic-factors-in-epithelial-ovarian-cancer
#19
Millena Prata Jammal, Agrimaldo Martins-Filho, Thales Parenti Silveira, Eddie Fernando Candido Murta, Rosekeila Simões Nomelini
INTRODUCTION: Ovarian cancer has a high mortality and delayed diagnosis. Inflammation is a risk factor for ovarian cancer, and the inflammatory response is involved in almost all stages of tumor development. Immunohistochemical staining in stroma and epithelium of a panel of cytokines in benign and malignant ovarian neoplasm was evaluated. In addition, immunostaining was related to prognostic factors in malignant tumors. METHOD: The study group comprised 28 ovarian benign neoplasias and 28 ovarian malignant neoplasms...
2016: Clinical Medicine Insights. Oncology
https://www.readbyqxmd.com/read/27510674/solid-pseudopapillary-neoplasm-of-the-ovary-with-metastases-to-the-omentum-and-regional-lymph-nodes
#20
Gaurav Pratap Singh Gahlot, Asit Ranjan Mridha, Mukund Sable, Mehar Chand Sharma, Raja Pramanik, Lalit Kumar
Extrapancreatic solid pseudopapillary neoplasms (SPNs) are rare tumors, which bear morphological, immunohistochemical, and molecular features similar to those of pancreatic counterparts. SPN occurs primarily in adolescent girls and young women. It is considered to be a malignant neoplasm with low-grade biology. Ovarian SPNs are uncommon, have benign morphology, usually limited to the ovary and local surgical excision is curative. We report an unusual case of SPN of right ovary with extraovarian spread and metastases to lymph nodes...
July 2016: Indian Journal of Pathology & Microbiology
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