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https://www.readbyqxmd.com/read/27933473/high-percentage-of-ibd-patients-with-indefinite-fecal-calprotectin-levels-additional-value-of-a-combination-score
#1
Alexander G L Bodelier, Daisy Jonkers, Tim van den Heuvel, Evelien de Boer, Wim Hameeteman, Ad A M Masclee, Marie J Pierik
BACKGROUND AND AIM: Monitoring mucosal inflammation in inflammatory bowel disease (IBD) is of major importance to prevent complications and improve long-term disease outcome. The correlation of clinical activity indices with endoscopic disease activity is, however, moderate. Fecal calprotectin (FC) is a better predictor of mucosal inflammation, but values between 100 and 250 µg/g are difficult to interpret in clinical practice. We aimed to evaluate the occurrence of indefinite FC levels in a real-life IBD cohort and study the additional value of a combination of biochemical markers and clinical activity indices...
December 8, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27933214/integrating-next-generation-sequencing-into-clinical-oncology-strategies-promises-and-pitfalls
#2
REVIEW
Peter Horak, Stefan Fröhling, Hanno Glimm
We live in an era of genomic medicine. The past five years brought about many significant achievements in the field of cancer genetics, driven by rapidly evolving technologies and plummeting costs of next-generation sequencing (NGS). The official completion of the Cancer Genome Project in 2014 led many to envision the clinical implementation of cancer genomic data as the next logical step in cancer therapy. Stemming from this vision, the term 'precision oncology' was coined to illustrate the novelty of this individualised approach...
2016: ESMO Open
https://www.readbyqxmd.com/read/27933154/improving-diagnosis-for-congenital-cataract-by-introducing-ngs-genetic-testing
#3
Mohammud Musleh, Jane Ashworth, Graeme Black, Georgina Hall
Childhood cataract (CC) has an incidence of 3.5 per 10,000 by age 15 years. Diagnosis of any underlying cause is important to ensure effective and prompt management of multisystem complications, to facilitate accurate genetic counselling and to streamline multidisciplinary care. Next generation sequencing (NGS) has been shown to be effective in providing an underlying diagnosis in 70% of patients with CC in a research setting. This project aimed to integrate NGS testing in CC within six months of presentation and increase the rate of diagnosis...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27932890/high-expression-of-hmga2-predicts-poor-survival-in-patients-with-clear-cell-renal-cell-carcinoma
#4
Ning Na, Tujie Si, Zhengyu Huang, Bin Miao, Liangqing Hong, Heng Li, Jiang Qiu, Jianguang Qiu
High-mobility group AT-hook 2 (HMGA2) is involved in a wide spectrum of biological processes and is upregulated in several tumors, but its role in renal carcinoma remains unclear. The aim of this study was to examine the expression of HMGA2 and its relationship to the overall survival (OS) of patients with non-metastatic clear cell renal cell carcinoma (ccRCC) following surgery. The expression of HMGA2 was evaluated retrospectively by immunohistochemistry (IHC) in 162 patients with ccRCC who underwent nephrectomy in 2003 and 2004...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27932677/suite-of-clinically-relevant-functional-assays-to-address-therapeutic-efficacy-and-disease-mechanism-in-the-dystrophic-mdx-mouse
#5
Yafeng Song, Shira Tziporah Rosenblum, Leon Morales, Mihail Petrov, Christopher Greer, Samantha Globerman, Hansell H Stedman
Duchenne muscular dystrophy (DMD) is a progressive primary myodegenerative disease caused by a genetic deficiency of the 427 KD cytoskeletal protein dystrophin. Despite its single-gene etiology, DMD's complex pathogenesis remains poorly understood, complicating the extrapolation from results of preclinical studies in genetic homologues to the design of informative clinical trials. Here we describe novel phenotypic assays which when applied to the mdx mouse resemble recently used primary endpoints for DMD clinical trials...
December 8, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27932671/coupling-of-eit-with-computational-lung-modeling-for-predicting-patient-specific-ventilatory-responses
#6
Christian J Roth, Tobias Becher, Inez Frerichs, Norbert Weiler, Wolfgang A Wall
Providing personalised optimal mechanical ventilation for patients with acute or chronic respiratory failure is still a challenge within a clinical setting for each case anew. In this article, we integrate electrical impedance tomography (EIT) monitoring into a powerful patient-specific computational lung model to create an approach for personalising protective ventilatory treatment. The underlying computational lung model is able to predict global quantities e.g., tracheal flow and tidal volume, as well as local tissue aeration and strains for any ventilation manoeuvre...
December 8, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27932552/microfluidic-analysis-of-oocyte-and-embryo-biomechanical-properties-to-improve-outcomes-in-assisted-reproductive-technologies
#7
REVIEW
Livia Z Yanez, David B Camarillo
Measurement of oocyte and embryo biomechanical properties has recently emerged as an exciting new approach to obtain a quantitative, objective estimate of developmental potential. However, many traditional methods for probing cell mechanical properties are time consuming, labor intensive and require expensive equipment. Microfluidic technology is currently making its way into many aspects of assisted reproductive technologies (ART), and is particularly well suited to measure embryo biomechanics due to the potential for robust, automated single-cell analysis at a low cost...
December 8, 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27932338/meaning-of-living-with-severe-chronic-obstructive-lung-disease-a-qualitative-study
#8
Gabriella Marx, Maximilian Nasse, Henrikje Stanze, Sonja Owusu Boakye, Friedemann Nauck, Nils Schneider
OBJECTIVES: To explore what it means for patients to live with chronic obstructive pulmonary disease (COPD) as an incurable and constantly progressing disease. DESIGN: Qualitative longitudinal study using narrative and semistructured interviews. This paper presents findings of the initial interviews. Analysis using grounded theory. SETTING: Lung care clinics and community care in Lower Saxony, Germany. PARTICIPANTS: 17 patients with advanced-stage COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) III/IV)...
December 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27932276/the-why-and-how-of-amino-acid-analytics-in-cancer-diagnostics-and-therapy
#9
REVIEW
Friederike Manig, Konstantin Kuhne, Cläre von Neubeck, Uwe Schwarzenbolz, Zhanru Yu, Benedikt M Kessler, Jens Pietzsch, Leoni A Kunz-Schughart
Pathological alterations in cell functions are frequently accompanied by metabolic reprogramming including modifications in amino acid metabolism. Amino acid detection is thus integral to the diagnosis of many hereditary metabolic diseases. The development of malignant diseases as metabolic disorders comes along with a complex dysregulation of genetic and epigenetic factors affecting metabolic enzymes. Cancer cells might transiently or permanently become auxotrophic for non-essential or semi-essential amino acids such as asparagine or arginine...
December 5, 2016: Journal of Biotechnology
https://www.readbyqxmd.com/read/27932261/does-adding-clinical-data-to-administrative-data-improve-agreement-among-hospital-quality-measures
#10
Amresh D Hanchate, Kelly L Stolzmann, Amy K Rosen, Aaron S Fink, Michael Shwartz, Arlene S Ash, Hassen Abdulkerim, Mary Jo V Pugh, Priti Shokeen, Ann Borzecki
BACKGROUND: Hospital performance measures based on patient mortality and readmission have indicated modest rates of agreement. We examined if combining clinical data on laboratory tests and vital signs with administrative data leads to improved agreement with each other, and with other measures of hospital performance in the nation's largest integrated health care system. METHODS: We used patient-level administrative and clinical data, and hospital-level data on quality indicators, for 2007-2010 from the Veterans Health Administration (VA)...
December 5, 2016: Healthcare
https://www.readbyqxmd.com/read/27932206/detailed-analysis-of-balb-c-mice-challenged-with-wild-type-rotavirus-edim-provide-an-alternative-for-infection-model-of-rotavirus
#11
Jialiang Du, Zhiling Lan, Yueyue Liu, Yan Liu, Yanchao Li, Xiangming Li, Tai Guo
Mouse is one of the infection animal models for rotavirus. Since the optimal age of mouse sensitive to rotavirus infection thus far has not been unified, we elucidated clinical symptoms, immune responses and pathological changes of mice in different ages after challenged by murine rotavirus wild strain EDIM (Epidemic Diarrhea of Infant Mice) to provide data for the estimation. One-week-old, two-week-old, and three-week-old BALB/c mice were inoculated with EDIM in the challenge dose of 235 ID50, 470 ID50 and 705 ID50 respectively and were compared to mock-infected controls...
December 5, 2016: Virus Research
https://www.readbyqxmd.com/read/27931974/mathematical-modeling-of-atopic-dermatitis-reveals-double-switch-mechanisms-underlying-four-common-disease-phenotypes
#12
Elisa Domínguez-Hüttinger, Panayiotis Christodoulides, Kosuke Miyauchi, Alan D Irvine, Mariko Okada-Hatakeyama, Masato Kubo, Reiko J Tanaka
BACKGROUND: The skin barrier acts as the first line of defense against constant exposure to biological, microbial, physical and chemical environmental stressors. Dynamic interplay between defects in the skin barrier, dysfunctional immune responses, and environmental stressors are major factors in the development of atopic dermatitis (AD). A systems-biology modeling approach can yield significant insights into these complex and dynamic processes through integration of prior biological data...
December 5, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27931880/predictive-diagnosis-of-major-depression-using-nmr-based-metabolomics-and-least-squares-support-vector-machine
#13
Hong Zheng, Peng Zheng, Liangcai Zhao, Jianmin Jia, Shengli Tang, Pengtao Xu, Peng Xie, Hongchang Gao
BACKGROUND: Major depressive (MD) disorder is a serious psychiatric disorder that can result in suicidal behavior if not treated. The MD diagnosis using a standardized instrument instead of a structured interview will be advantageous for treatment and management of the MD, but so far no such technique exists. We developed an integrated analytical method of NMR-based metabolomics and least squares-support vector machine (LS-SVM) for predictive diagnosis of the MD. METHODS: The metabolite profiles in clinical plasma samples obtained from 72 depressive patients and 54 healthy subjects were analyzed by NMR spectroscopy...
December 5, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27931616/micrornas-in-cardiovascular-disease
#14
REVIEW
Temo Barwari, Abhishek Joshi, Manuel Mayr
Micro-ribonucleic acids (miRNAs) are in the spotlight as post-transcriptional regulators of gene expression. More than 1,000 miRNAs are encoded in the human genome. In this review, we provide an introduction to miRNA biology and research methodology, and highlight advances in cardiovascular research to date. This includes the potential of miRNAs as therapeutic targets in cardiac and vascular disease, and their use as novel biomarkers. Although some miRNA therapies are already undergoing clinical evaluation, we stress the importance of integrating current knowledge of miRNA biology into a systemic context...
December 13, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27931034/historical-perspective-on-clinical-trials-of-carnitine-in-children-and-adults
#15
Neil R M Buist
The metabolic roles of carnitine have been greatly clarified over the past 50 years, and it is now well established that carnitine is a key player in mitochondrial generation of energy and metabolism of acetyl coenzyme A. A therapeutic role for carnitine in treatment of nutritional deficiencies in infants and children was first demonstrated in 1958, and since that time it has been used to treat a number of inborn errors of metabolism. Carnitine was approved by the US Food and Drug Administration in 1985 for treatment of 'primary carnitine deficiency', and later in 1992 for treatment of 'secondary carnitine deficiency', a definition that included the majority of relevant metabolic disorders associated with low or abnormal plasma carnitine levels...
December 9, 2016: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/27931005/microfluidic-immunosensor-for-rapid-and-highly-sensitive-salivary-cortisol-quantification
#16
V Pinto, P Sousa, S O Catarino, M Correia-Neves, G Minas
This paper presents a novel poly(dimethylsiloxane) (PDMS) microfluidic immunosensor that integrates a complementary metal-oxide-semiconductor (CMOS) optical detection system for a rapid and highly-sensitive quantification of salivary cortisol. The simple and non-invasive method of saliva sampling provides an interesting alternative to the blood, allowing a fast sampling at short intervals, relevant for many clinical diagnostic applications. The developed approach is based on the covalent immobilization of a coating antibody (Ab), a polyclonal anti-IgG, onto a treated PDMS surface...
November 30, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27930963/-teaching-on-the-run-with-australian-midwives-in-a-tertiary-maternity-hospital
#17
Yvonne Hauck, Lucy Lewis, Alissa Pemberton, Caroline Crichton, Janice Butt
Teaching On The Run (TOTR) is an Australian program for health professionals involved in clinical supervision. An amended TOTR program was evaluated with midwives acting as preceptors assisting learners integrate theory with clinical practice. A mixed method study was employed to compare midwives' perceived skills and confidence before and after completion of TOTR workshops. A secondary aim explored midwifery learners' (students and new graduates) perceptions of support from preceptors during the implementation of TOTR...
November 25, 2016: Nurse Education in Practice
https://www.readbyqxmd.com/read/27930962/aiming-for-excellence-a-simulation-based-study-on-adapting-and-testing-an-instrument-for-developing-non-technical-skills-in-norwegian-student-nurse-anaesthetists
#18
Fiona M Flynn, Kjersti Sandaker, Randi Ballangrud
There is increasing focus on building safety into anaesthesia practice, with excellence in anaesthesia as an aspirational goal. Non-technical skills are an important factor in excellence and improved patient safety, though there have been few systematic attempts at integrating them into anaesthesia nursing education. This study aimed to test the reliability of NANTS-no, a specially adapted behavioural marker system for nurse anaesthetists in Norway, and explore the development of non-technical skills in student nurse anaesthetists...
November 29, 2016: Nurse Education in Practice
https://www.readbyqxmd.com/read/27930921/nursing-students-attitudes-toward-persons-who-are-aged-an-integrative-review
#19
REVIEW
Susan Hovey, Mary J Dyck, Cynthia Reese, MyoungJin Kim
OBJECTIVES: To analyze empirical studies from the United States and Canada to gain an understanding on how nursing education affects nursing students' attitudes toward persons who are aged. DESIGN: An integrative literature review was completed using Garrard's (2011) Matrix Method. DATA SOURCES: Articles were identified through the electronic database search engines of CINAHL, Pub Med, and Academic Search Complete. Only peer reviewed research articles from 2009 to 2015 were reviewed...
November 27, 2016: Nurse Education Today
https://www.readbyqxmd.com/read/27930609/feasibility-and-acceptability-of-health-communication-interventions-within-a-combination-intervention-strategy-for-improving-linkage-and-retention-in-hiv-care-in-mozambique
#20
Roberta Sutton, Maria Lahuerta, Fatima Abacassamo, Laurence Ahoua, Maria Tomo, Matthew R Lamb, Batya Elul
BACKGROUND: Challenges to ensuring timely linkage to and retention in HIV care are well documented. Combination intervention strategies can be effective in improving the HIV care continuum. Data on feasibility and acceptability of intervention types within intervention packages are limited. METHODS: The Engage4Health study assessed the effectiveness of a combination intervention strategy to increase linkage and retention among adults newly diagnosed with HIV in Mozambique...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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