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https://www.readbyqxmd.com/read/28894932/genomic-insights-into-temperature-dependent-transcriptional-responses-of-kosmotoga-olearia-a-deep-biosphere-bacterium-that-can-grow-from-20-to-79%C3%A2-%C3%A2-c
#1
Stephen M J Pollo, Abigail A Adebusuyi, Timothy J Straub, Julia M Foght, Olga Zhaxybayeva, Camilla L Nesbø
Temperature is one of the defining parameters of an ecological niche. Most organisms thrive within a temperature range that rarely exceeds ~30 °C, but the deep subsurface bacterium Kosmotoga olearia can grow over a temperature range of 59 °C (20-79 °C). To identify genes correlated with this flexible phenotype, we compared transcriptomes of K. olearia cultures grown at its optimal 65 °C to those at 30, 40, and 77 °C. The temperature treatments affected expression of 573 of 2224 K. olearia genes. Notably, this transcriptional response elicits re-modeling of the cellular membrane and changes in metabolism, with increased expression of genes involved in energy and carbohydrate metabolism at high temperatures and up-regulation of amino acid metabolism at lower temperatures...
September 11, 2017: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/28843016/directional-leads-for-deep-brain-stimulation-opportunities-and-challenges
#2
W M Michael Schüpbach, Stéphan Chabardes, Cordula Matthies, Claudio Pollo, Frank Steigerwald, Lars Timmermann, Veerle Visser Vandewalle, Jens Volkmann, P Richard Schuurman
No abstract text is available yet for this article.
August 26, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28801098/synthesis-and-in-vitro-evaluation-of-ca-2-channel-blockers-1-4-dihydropyridines-analogues-against-trypanosoma-cruzi-and-leishmania-amazonensis-sar-analysis
#3
Luiz A E Pollo, Milene H de Moraes, Júlia Cisilotto, Tânia B Creczynski-Pasa, Maique W Biavatti, Mario Steindel, Louis P Sandjo
Drugs containing the1,4-dihydropyridine (DHP) core have recently attracted attention concerning their antiparasitic effect against various species of Leishmania and Trypanosoma. This approach named drugs repositioning led to interesting results, which have prompted us to prepare 21 DHP's analogues. The 1,4-DHP scaffold was decorated with different function groups at tree points including the nitrogen atom (NH and N-phenyl), the aryl group attached to C-4 (various substituted aryl residues) and the carbon atoms 2 and 6 (bearing Ph or Me groups)...
August 9, 2017: Parasitology International
https://www.readbyqxmd.com/read/28772275/deep-brain-stimulation-for-tremor-is-there-a-common-structure
#4
Michael Fiechter, Andreas Nowacki, Markus F Oertel, Jens Fichtner, Ines Debove, M Lenard Lachenmayer, Roland Wiest, Claudio L Bassetti, Andreas Raabe, Alain Kaelin-Lang, Michael W Schüpbach, Claudio Pollo
BACKGROUND: Subthalamic nucleus (STN) stimulation has been recognized to control resting tremor in Parkinson disease. Similarly, thalamic stimulation (ventral intermediate nucleus; VIM) has shown tremor control in Parkinson disease, essential, and intention tremors. Recently, stimulation of the posterior subthalamic area (PSA) has been associated with excellent tremor control. Thus, the optimal site of stimulation may be located in the surrounding white matter. AIMS: The objective of this work was to investigate the area of stimulation by determining the contact location correlated with the best tremor control in STN/VIM patients...
2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28747664/mutations-targeting-the-coagulation-pathway-are-enriched-in-brain-metastases
#5
Cristina Richichi, Lorenzo Fornasari, Giorgio E M Melloni, Paola Brescia, Monica Patanè, Massimiliano Del Bene, Dana A M Mustafa, Johan M Kros, Bianca Pollo, Giancarlo Pruneri, Angela Sciandivasci, Elisabetta Munzone, Francesco DiMeco, Pier Giuseppe Pelicci, Laura Riva, Giuliana Pelicci
Brain metastases (BMs) are the most common malignancy of the central nervous system. Recently it has been demonstrated that plasminogen activator inhibitor serpins promote brain metastatic colonization, suggesting that mutations in serpins or other members of the coagulation cascade can provide critical advantages during BM formation. We performed whole-exome sequencing on matched samples of breast cancer and BMs and found mutations in the coagulation pathway genes in 5 out of 10 BM samples. We then investigated the mutational status of 33 genes belonging to the coagulation cascade in a panel of 29 BMs and we identified 56 Single Nucleotide Variants (SNVs)...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28634794/evaluation-in-situ-of-genotoxicity-and-stress-in-south-american-common-toad-rhinella-arenarum-in-environments-related-to-fluorite-mine
#6
Favio E Pollo, Pablo R Grenat, Zulma A Salinas, Manuel A Otero, Nancy E Salas, Adolfo L Martino
Little attention has been paid to the impact of wastewater generated by mining activities on fluoride. In this study, we evaluated the hematology responses of common South American toad Rhinella arenarum inhabiting natural and artificial environments associated with a fluorite mine from central Argentina. We analyzed three sampling stations associated with the fluorite mine: (I) Los Cerros Negros stream (CN), which runs on granitic rock with a high fluorite content; (II) Los Vallecitos stream (LV), which runs on metamorphic rock with low fluorite content; and (III) artificial decantation ponds (DP) containing sediments produced by fluorite flotation process...
June 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28562815/health-conditions-and-memory-performance-a-study-with-older-adult-women
#7
Alice Milani Nespollo, Samira Reschetti Marcon, Nathalie Vilma Pollo de Lima, Tatiane Lebre Dias, Mariano Martínez Espinosa
Objective: to verify the correlation between health condition and memory performance of older adult women in the community. Method: Analytical cross-sectional study developed with 28 older adult women living in Cuiabá-MT. They answered the Mini-Mental State Examination (MMSE), and a shortened Geriatric Depression Scale (GDS-15) to screen for dementia and depression symptoms. Memory skills were assessed through Rey Auditory Verbal Learning Test (RAVLT). Results: The mean age was 66...
May 2017: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/28165155/performance-of-anti-hcv-testing-in-dried-blood-spots-and-saliva-according-to-hiv-status
#8
Geane Lopes Flores, Helena Medina Cruz, Vanessa Alves Marques, Cristiane Alves Villela-Nogueira, Denise Vigo Potsch, Silvia Beatriz May, Carlos Eduardo Brandão-Mello, Marcia Maria Amendola Pires, Jose Henrique Pilotto, Priscila Pollo-Flores, Eliane Bordalo Cathalá Esberard, Claudia Ivantes, Lia Laura Lewis-Ximenez, Elisabeth Lampe, Livia Melo Villar
The use of saliva and dried blood spots (DBS) could increase access to HCV diagnosis for high-risk populations, such as HIV-infected individuals, but the performance of these assays has not been well established in this group. This study aims to evaluate HIV status, particularly TCD4(+) cell count and viral load, in the performance of anti-HCV testing using DBS and saliva. A total of 961 individuals classified as HCV+, HIV+, or HIV/HCV+, as well as negative controls, donated serum, DBS, and saliva samples for anti-HCV testing using a commercial enzyme immunoassay...
August 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28146158/poor-sensitivity-of-rapid-tests-for-the-detection-of-antibodies-to-the-hepatitis-b-virus-implications-for-field-studies
#9
Helena Medina Cruz, Leticia de Paula Scalioni, Vanessa Salete de Paula, Juliana Custódio Miguel, Kycia Maria Rodrigues do Ó, Flavio Augusto Pádua Milagres, Marcelo Santos Cruz, Francisco Inácio Bastos, Priscila Pollo Flores, Erotildes Leal, Ana Rita Coimbra Motta-Castro, Lia Laura Lewis-Ximenez, Elisabeth Lampe, Livia Melo Villar
Rapid tests (RTs) can be used as an alternative method for the conventional diagnosis of hepatitis B virus (HBV). This study aims to evaluate antibodies to HBsAg (anti-HBs) and antibodies to HBeAg (anti-HBe) RTs under different Brazilian settings. The following three groups were included: GI: viral hepatitis outpatient services; GII: low resource areas; and GIII: crack users and beauticians. Imuno-rápido anti-HBsAg™ and Imuno-rápido anti-HBeAg™ RTs were evaluated and showed specificities greater than 95% in all groups...
March 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28108401/constitutive-expression-and-characterization-of-a-surface-srs-ncsrs67-protein-of-neospora-caninum-with-no-orthologue-in-toxoplasma-gondii
#10
Marcos Alexandre Bezerra, Luiz Miguel Pereira, Aline Bononi, Carla Agostino Biella, Luciana Baroni, Leticia Pollo-Oliveira, Ana Patrícia Yatsuda
Neospora caninum is a parasite of the Apicomplexa phylum responsible for abortion and losses of fertility in cattle. As part of its intracellular cycle, the first interaction of the parasite with the target cell is performed with the surface proteins known as the SRS superfamily (Surface Antigen Glycoprotein - Related Sequences). SAG related or SRS proteins have been a target of intense research due to its immunodominant pattern, exhibiting potential as diagnostic and/or vaccine candidates. The aim of this study was the cloning, expression and characterization of the gene NcSRS67 of N...
April 2017: Parasitology International
https://www.readbyqxmd.com/read/28099876/antitumoral-activity-of-sesquiterpene-lactone-diacethylpiptocarphol-in-mice
#11
Fronza Alexandre Schefer, Sabel Ricardo, Carrenho Luise Zozula Blind, Pollo Luis, Bratti Letícia de Oliveira Souza, Monteiro Fabíola Branco Filippin, Biavatti Maique Weber, Kreuger Maria Regina Orofino
ETHNOPHARMACOLOGICAL RELEVANCE: Sesquiterpene lactones are organic compounds derived from plants that exhibit anti-inflammatory and antitumor activities being one of the locking mechanisms of action of NF-kB pathway and synthesis of cytokines such as IL-1 and TNF- α. AIM OF THE STUDY: The overall objective of the present study was to evaluate the antitumor activity of the sesquiterpene lactone diacethylpiptocarphol (DPC) from Vernonia scorpioides (Lam.) Pers. in animal models Ehrlich tumors that has shown antitumor activity...
February 23, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27997922/continuous-intraoperative-monitoring-of-temporal-lobe-epilepsy-surgery
#12
Rémi Tyrand, Shahan Momjian, Claudio Pollo, Christopher Lysakowski, Agustina M Lascano, Serge Vulliémoz, Karl Schaller, Colette Boëx
BACKGROUND/AIMS: The monitoring of interictal epileptiform discharge rates (IEDRs) all along anterior temporal lobe resections (ATLRs) has never been reported. Here the effect of ATLR on continuous IEDR monitoring is described. METHODS: IEDRs computed automatically during entire interventions were recorded in 34 patients (38.2%, 13/34 depth; 61.8%, 21/34 scalp electrodes only). Monitorings were invalidated when burst suppression occurred or if initial IEDRs were <5...
2016: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/27986944/survival-and-development-of-hermetia-illucens-diptera-stratiomyidae-a-biodegradation-agent-of-organic-waste
#13
Ana Clariza Samayoa, Wei-Ting Chen, Shaw-Yhi Hwang
The black soldier fly, Hermetia illucens (L.) (Diptera: Stratiomyidae), was reared on artificial diet (wheat bran and chicken feed) in the laboratory at 28ºC (immature stages) and under a greenhouse set at 28ºC (adults). Data were collected and analyzed based on an age-stage, two-sex life table. The intrinsic rate of increase (r), finite rate of increase (λ), net reproduction rate (R0), and mean generation time (T) were 0.0759 (d(-1)), 1.0759 (d(-1)), 68.225 offspring, and 55.635 d, respectively. The maximum reproductive value of females occurred at 54 d...
December 2016: Journal of Economic Entomology
https://www.readbyqxmd.com/read/27976470/esi-ms-2-and-anti-inflammatory-studies-of-cyclopropanic-triterpenes-uplc-esi-ms-and-ms-2-search-of-related-metabolites-from-donella-ubanguiensis
#14
Louis P Sandjo, Marcus V P Dos Santos Nascimento, Layzon A L da Silva, Antonio C M Munhoz, Luiz A E Pollo, Maique W Biavatti, Bonaventure T Ngadjui, Till Opatz, Tania S Fröde
INTRODUCTION: Triterpenes are one of the largest secondary metabolites groups spread in the plant kingdom with various skeletons. These metabolites have showed various bioactivities including anti-inflammatory activity. OBJECTIVE: The study aims to explore the mass spectrometry fragmentation of donellanic acids A-C (DA A-C), three compounds identified from Donella ubanguiensis; in addition, the fragmentation behaviour of these metabolites will serve as a fingerprint to search and characterise triterpenes congeners in fruits, bark and wood crude extracts of D...
January 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/27966027/combined-thalamic-and-subthalamic-deep-brain-stimulation-for-tremor-dominant-parkinson-s-disease
#15
Markus F Oertel, W Michael M Schüpbach, Joseph-André Ghika, Lennart H Stieglitz, Michael Fiechter, Alain Kaelin-Lang, Andreas Raabe, Claudio Pollo
Deep brain stimulation (DBS) in the thalamic ventral intermediate (Vim) or the subthalamic nucleus (STN) reportedly improves medication-refractory Parkinson's disease (PD) tremor. However, little is known about the potential synergic effects of combined Vim and STN DBS. We describe a 79-year-old man with medication-refractory tremor-dominant PD. Bilateral Vim DBS electrode implantation produced insufficient improvement. Therefore, the patient underwent additional unilateral left-sided STN DBS. Whereas Vim or STN stimulation alone led to partial improvement, persisting tremor resolution occurred after simultaneous stimulation...
February 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/27843765/t2-relaxometry-predicts-outcome-of-dbs-in-idiopathic-parkinson-s-disease
#16
Tarja Lönnfors-Weitzel, Thilo Weitzel, Johannes Slotboom, Claus Kiefer, Claudio Pollo, Michael Schüpbach, Markus Oertel, Alain Kaelin, Roland Wiest
INTRODUCTION: Deep brain stimulation (DBS) nowadays is a well-established treatment of motor symptoms in Parkinson's disease. The subthalamic nucleus (STN) is a common target for DBS, because motor improvements have been shown to be superior to best medical therapy, if DBS electrodes have been appropriately positioned. DBS target identification can be assisted by MRI beyond structural imaging by spatially resolved measurement of T2-relaxation times (T2r). AIM: We pose the question, whether T2r of the STN is linked to the severity of the disease and whether outcome of DBS may be correlated to an asymmetric manifestation of the disease...
2016: NeuroImage: Clinical
https://www.readbyqxmd.com/read/27761101/measures-of-kindergarten-spelling-and-their-relations-to-later-spelling-performance
#17
Rebecca Treiman, Brett Kessler, Tatiana Cury Pollo, Brian Byrne, Richard K Olson
Learning the orthographic forms of words is important for both spelling and reading. To determine whether some methods of scoring children's early spellings predict later spelling performance better than do other methods, we analyzed data from 374 U.S. and Australian children who took a 10-word spelling test at the end of kindergarten (mean age 6 years, 2 months) and a standardized spelling test approximately two years later. Surprisingly, scoring methods that took account of phonological plausibility did not outperform methods that were based only on orthographic correctness...
2016: Scientific Studies of Reading
https://www.readbyqxmd.com/read/27631560/intraoperative-acceleration-measurements-to-quantify-improvement-in-tremor-during-deep-brain-stimulation-surgery
#18
Ashesh Shah, Jérôme Coste, Jean-Jacques Lemaire, Ethan Taub, W M Michael Schüpbach, Claudio Pollo, Erik Schkommodau, Raphael Guzman, Simone Hemm-Ode
Deep brain stimulation (DBS) surgery is extensively used in the treatment of movement disorders. Nevertheless, methods to evaluate the clinical response during intraoperative stimulation tests to identify the optimal position for the implantation of the chronic DBS lead remain subjective. In this paper, we describe a new, versatile method for quantitative intraoperative evaluation of improvement in tremor with an acceleration sensor that is mounted on the patient's wrist during surgery. At each anatomical test position, the improvement in tremor compared to the initial tremor is estimated on the basis of extracted outcome measures...
September 8, 2016: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/27601248/first-ex-vivo-validation-of-a-radioguided-surgery-technique-with-%C3%AE-radiation
#19
E Solfaroli Camillocci, M Schiariti, V Bocci, A Carollo, G Chiodi, M Colandrea, F Collamati, M Cremonesi, R Donnarumma, M E Ferrari, P Ferroli, F Ghielmetti, C M Grana, C Mancini Terracciano, M Marafini, S Morganti, M Patanè, G Pedroli, B Pollo, L Recchia, A Russomando, M Toppi, G Traini, R Faccini
PURPOSE: A radio-guided surgery technique with β(-)-emitting radio-tracers was suggested to overcome the effect of the large penetration of γ radiation. The feasibility studies in the case of brain tumors and abdominal neuro-endocrine tumors were based on simulations starting from PET images with several underlying assumptions. This paper reports, as proof-of-principle of this technique, an ex vivo test on a meningioma patient. This test allowed to validate the whole chain, from the evaluation of the SUV of the tumor, to the assumptions on the bio-distribution and the signal detection...
September 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27582543/tumor-initiating-cell-frequency-is-relevant-for-glioblastoma-aggressiveness
#20
Cristina Richichi, Daniela Osti, Massimiliano Del Bene, Lorenzo Fornasari, Monica Patanè, Bianca Pollo, Francesco DiMeco, Giuliana Pelicci
Glioblastoma (GBM) is maintained by a small subpopulation of tumor-initiating cells (TICs). The arduous assessment of TIC frequencies challenges the prognostic role of TICs in predicting the clinical outcome in GBM patients. We estimated the TIC frequency in human GBM injecting intracerebrally in mice dissociated cells without any passage in culture.All GBMs contained rare TICsand were tumorigenic in vivo but only 54% of them grew in vitro as neurospheres. We demonstrated that neurosphere formation in vitro did not foretell tumorigenic ability in vivo and frequencies calculated in vitro overestimated the TIC content...
November 1, 2016: Oncotarget
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