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https://www.readbyqxmd.com/read/29767306/correction-to-results-of-nimotuzumab-and-vinorelbine-radiation-and-re-irradiation-for-diffuse-pontine-glioma-in-childhood
#1
Maura Massimino, Veronica Biassoni, Rosalba Miceli, Elisabetta Schiavello, Monika Warmuth-Metz, Piergiorgio Modena, Michela Casanova, Emilia Pecori, Felice Giangaspero, Manila Antonelli, Francesca Romana Buttarelli, Paolo Potepan, Bianca Pollo, Raffaele Nunziata, Filippo Spreafico, Marta Podda, Andrea Anichini, Carlo Alfredo Clerici, Iacopo Sardi, Loris De Cecco, Udo Bode, Ferdinand Bach, Lorenza Gandola
The therapeutic experience reported in the paper was conceived after the use of nimotuzumab and radiotherapy (BSCPED-05 international multicentric trial, EUDRACT 2005-003100-11) in 2009 when we decided to explore the activity of the same combination plus vinorelbine (see the paper for the rationale).
May 16, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29753683/evaluating-resective-surgery-targets-in-epilepsy-patients-a-comparison-of-quantitative-eeg-methods
#2
Michael Müller, Kaspar Schindler, Marc Goodfellow, Claudio Pollo, Christian Rummel, Andreas Steimer
BACKGROUND: Quantitative analysis of intracranial EEG is a promising tool to assist clinicians in the planning of resective brain surgery in patients suffering from pharmacoresistant epilepsies. Quantifying the accuracy of such tools, however, is nontrivial as a ground truth to verify predictions about hypothetical resections is missing. NEW METHOD: As one possibility to address this, we use customized hypotheses tests to examine the agreement of the methods on a common set of patients...
May 10, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29734511/factors-associated-with-quality-of-life-in-facial-melasma-a-cross-sectional-study
#3
Camila F Pollo, Luciane Db Miot, Silmara Meneguin, Hélio A Miot
BACKGROUND: Melasma is a common chronic focal hypermelanosis that affects photexposed areas as face, mainly in women at fertile age. It inflicts a significant impact in quality of life, nevertheless, quality of life scores (e.g. MELASQoL) are not strongly correlated with clinical severity (e.g. MASI) in facial melasma, suggesting that different factors can influence the perception of disease beyond the clinical extension or the intensity of pigmentation. OBJECTIVES: To explore clinical and sociodemographic aspects that influences MELASQoL scores...
May 7, 2018: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29618563/erratum-for-the-research-article-constitutive-and-tnf%C3%AE-inducible-expression-of-chondroitin-sulfate-proteoglycan-4-in-glioblastoma-and-neurospheres-implications-for-car-t-cell-therapy-by-s-pellegatta-b-savoldo-n-di-ianni-c-corbetta-y-chen-m-patan%C3%A3-c-sun-b-pollo
#4
https://www.readbyqxmd.com/read/29618087/extensive-and-systematic-rewiring-of-histone-post-translational-modifications-in-cancer-model-systems
#5
Roberta Noberini, Daniela Osti, Claudia Miccolo, Cristina Richichi, Michela Lupia, Giacomo Corleone, Sung-Pil Hong, Piergiuseppe Colombo, Bianca Pollo, Lorenzo Fornasari, Giancarlo Pruneri, Luca Magnani, Ugo Cavallaro, Susanna Chiocca, Saverio Minucci, Giuliana Pelicci, Tiziana Bonaldi
Histone post-translational modifications (PTMs) generate a complex combinatorial code that regulates gene expression and nuclear functions, and whose deregulation has been documented in different types of cancers. Therefore, the availability of relevant culture models that can be manipulated and that retain the epigenetic features of the tissue of origin is absolutely crucial for studying the epigenetic mechanisms underlying cancer and testing epigenetic drugs. In this study, we took advantage of quantitative mass spectrometry to comprehensively profile histone PTMs in patient tumor tissues, primary cultures and cell lines from three representative tumor models, breast cancer, glioblastoma and ovarian cancer, revealing an extensive and systematic rewiring of histone marks in cell culture conditions, which includes a decrease of H3K27me2/me3, H3K79me1/me2 and H3K9ac/K14ac, and an increase of H3K36me1/me2...
March 29, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29570012/validation-of-diffusion-tensor-imaging-tractography-to-visualize-the-dentatorubrothalamic-tract-for-surgical-planning
#6
Andreas Nowacki, Jürgen Schlaier, Ines Debove, Claudio Pollo
OBJECTIVE The dentatorubrothalamic tract (DRTT) has been suggested as the anatomical substrate for deep brain stimulation (DBS)-induced tremor alleviation. So far, little is known about how accurately and reliably tracking results correspond to the anatomical DRTT. The objective of this study was to systematically investigate and validate the results of different tractography approaches for surgical planning. METHODS The authors retrospectively analyzed 4 methodological approaches for diffusion tensor imaging (DTI)-based fiber tracking using different regions of interest in 6 patients with essential tremor...
March 23, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29491184/constitutive-and-tnf%C3%AE-inducible-expression-of-chondroitin-sulfate-proteoglycan-4-in-glioblastoma-and-neurospheres-implications-for-car-t-cell-therapy
#7
Serena Pellegatta, Barbara Savoldo, Natalia Di Ianni, Cristina Corbetta, Yuhui Chen, Monica Patané, Chuang Sun, Bianca Pollo, Soldano Ferrone, Francesco DiMeco, Gaetano Finocchiaro, Gianpietro Dotti
The heterogeneous expression of tumor-associated antigens limits the efficacy of chimeric antigen receptor (CAR)-redirected T cells (CAR-Ts) for the treatment of glioblastoma (GBM). We have found that chondroitin sulfate proteoglycan 4 (CSPG4) is highly expressed in 67% of the GBM specimens with limited heterogeneity. CSPG4 is also expressed on primary GBM-derived cells, grown in vitro as neurospheres (GBM-NS), which recapitulate the histopathology and molecular characteristics of primary GBM. CSPG4.CAR-Ts efficiently controlled the growth of GBM-NS in vitro and in vivo upon intracranial tumor inoculation...
February 28, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29470712/diversity-of-mammomonogamus-nematoda-syngamidae-in-large-african-herbivores
#8
Barbora Červená, Kristýna Hrazdilová, Peter Vallo, Barbora Pafčo, Tereza Fenyková, Klára Judita Petrželková, Angelique Todd, Nikki Tagg, Nadege Wangue, Estevam G Lux Hoppe, Marcela Figuerêdo Duarte Moraes, Ivan Moura Lapera, Andressa de Souza Pollo, Ana Cláudia Alexandre de Albuquerque, David Modrý
Four species of Mammomonogamus are known from large African herbivores. A recent study demonstrated that a single Mammomonogamus species was shared by both western lowland gorillas (Gorilla gorilla gorilla) and African forest elephants (Loxodonta cyclotis) in Central African Republic, suggesting lower species diversity than previously described in literature. We examined more than 500 fecal samples collected from sympatric African forest elephants, western lowland gorillas, and African forest buffaloes (Syncerus caffer nanus) at four study sites across Central Africa and examined them by coproscopic methods to detect Mammomonogamus eggs, which were found at three of the study sites...
April 2018: Parasitology Research
https://www.readbyqxmd.com/read/29465575/impact-of-vitamin-d-receptor-and-binding-protein-gene-polymorphisms-in-clinical-and-laboratory-data-of-hcv-patients-cross-sectional-study
#9
Letícia de Paula Scalioni, Betânia Rodrigues Dos Santos, Poli Mara Spritzer, Cristiane Alves Villela-Nogueira, Lia Laura Lewis-Ximenez, Priscila Pollo-Flores, Eliane Bordalo Cathalá Esberard, Carlos Eduardo Brandão-Mello, Elisabeth Lampe, Livia Melo Villar
Potential relationship of vitamin D, vitamin D receptor (VDR), and vitamin D binding protein (DBP) have been suggested in the pathophysiology of hepatitis C virus (HCV) infection. The aim of this observational study is to determine vitamin D levels, and VDR and DBP genetic polymorphism according demographic and laboratory data in chronic HCV patients (CHC).A total of 148 CHC patients gave serum samples for testing 25-hydroxyvitamin D (25 (OH)D) level by immunochemiluminometric assay (<20 ng/mL defined as deficient) and donated blood samples to allelic discrimination analysis using TaqMan assays...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29438683/management-of-the-american-cockroach-s-oothecae-the-potential-of-entomopathogenic-fungi-control
#10
Mariah Valente Baggio-Deibler, Marcelo da Costa Ferreira, Antonio Carlos Monteiro, Andressa de Souza-Pollo, Manoel Victor Franco Lemos
The Periplaneta americana species is an annoyance to man, causing allergies and damage to clothes and documents. It has the ability to spread pathogens and requires control measures. Control with natural enemies is less aggressive and can currently be applied with less risk than other techniques, such as chemical control, which is the main method used worldwide to control its post-embryonic stages. The potential microbial control of nymphs and adults of this pest has been shown, but little is known about its oothecae...
March 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29399160/microglia-immunophenotyping-in-gliomas
#11
Laura Annovazzi, Marta Mellai, Enrica Bovio, Samanta Mazzetti, Bianca Pollo, Davide Schiffer
Microglia, once assimilated to peripheral macrophages, in gliomas has long been discussed and currently it is hypothesized to play a pro-tumor role in tumor progression. Uncertain between M1 and M2 polarization, it exchanges signals with glioma cells to create an immunosuppressive microenvironment and stimulates cell proliferation and migration. Four antibodies are currently used for microglia/macrophage identification in tissues that exhibit different cell forms and cell localization. The aim of the present work was to describe the distribution of the different cell forms and to deduce their significance on the basis of what is known on their function from the literature...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29204962/adult-leukoencephalopathies-with-prominent-infratentorial-involvement-can-be-caused-by-erdheim-chester-disease
#12
Luisa Chiapparini, Giulio Cavalli, Tiziana Langella, Anna Venerando, Giacomo De Luca, Sergio Raspante, Giorgio Marotta, Bianca Pollo, Giuseppe Lauria, Maria Giulia Cangi, Simonetta Gerevini, Andrea Botturi, Davide Pareyson, Lorenzo Dagna, Ettore Salsano
BACKGROUND: Leukoencephalopathies with prominent involvement of cerebellum and brainstem, henceforward called prominent infratentorial leukoencephalopathies (PILs), encompass a variety of inherited and acquired white matter diseases. Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis likely under-diagnosed as cause of adult PIL. METHODS: We reviewed the clinical and laboratory information of ten consecutive sporadic adult patients with PIL of unknown origin, who were investigated for ECD...
February 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29184769/diffuse-glioblastoma-resembling-acute-hemorrhagic-leukoencephalitis
#13
Carla Schettino, Ferdinando Caranci, Giacomo Lus, Elisabetta Signoriello, Marica Eoli, Elena Anghileri, Bianca Pollo, Mariarosa A B Melone, Giuseppe Di Iorio, Gaetano Finocchiaro, Lorenzo Ugga, Enrico Tedeschi
We report the case of a young man with sudden onset of diplopia after an upper respiratory tract infection. Based on the first radiological findings acute hemorrhagic leukoencephalitis, a variant of acute disseminated encephalomyelitis, was suspected and treatment with high dose intravenous dexamethasone was started but it was stopped for intolerance. The patient clinically worsened, developing gait instability, ataxia and ophthalmoplegia; brain MRI performed 20 days later showed severe progression of the disease with subependymal dissemination...
October 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29150884/directional-local-field-potentials-a-tool-to-optimize-deep-brain-stimulation
#14
Gerd Tinkhauser, Alek Pogosyan, Ines Debove, Andreas Nowacki, Syed Ahmar Shah, Kathleen Seidel, Huiling Tan, John-Stuart Brittain, Katrin Petermann, Lazzaro di Biase, Markus Oertel, Claudio Pollo, Peter Brown, Michael Schuepbach
BACKGROUND: Although recently introduced directional DBS leads provide control of the stimulation field, programing is time-consuming. OBJECTIVES: Here, we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with PD. METHODS: Intraoperative local field potentials were recorded from directional contacts in the STN of 12 patients and beta activity compared with the results of the clinical contact review performed after 4 to 7 months...
January 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29122539/a-new-polyacetylene-glucoside-from-vernonia-scorpioides-and-its-potential-antihyperglycemic-effect
#15
Luiz A E Pollo, Marisa J Frederico, Adailton J Bortoluzzi, Fátima R M B Silva, Maique W Biavatti
Natural polyacetylene compounds have been found mainly in seven botanical families and remain underexplored and understudied, despite its inherent chemical and biological reactivity, due to the presence of conjugated triple bonds. Some polyacetylene glucosides have been found to stimulate glucose uptake in C5BL/ks-db/db obese diabetic mice, and since polyacetylene glucosides previously found in Vernonia scorpioides showed little to none cytotoxicity, in this study the antihyperglycemic potential of a new V...
January 5, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29018053/fluorescein-guided-surgery-for-resection-of-high-grade-gliomas-a-multicentric-prospective-phase-ii-study-fluoglio
#16
Francesco Acerbi, Morgan Broggi, Karl-Michael Schebesch, Julius Höhne, Claudio Cavallo, Camilla De Laurentis, Marica Eoli, Elena Anghileri, Maura Servida, Carlo Boffano, Bianca Pollo, Marco Schiariti, Sergio Visintini, Cristina Montomoli, Lorenzo Bosio, Emanuele La Corte, Giovanni Broggi, Alexander Brawanski, Paolo Ferroli
Purpose: Sodium fluorescein is a dye that, intravenously injected, selectively accumulates in high-grade glioma (HGG) tissue through a damaged blood-brain barrier. In this article, the final results of a multicentric prospective phase II trial (FLUOGLIO) on fluorescein-guided HGG resection through a dedicated filter on the surgical microscope were reported. Methods: Patients with suspected HGGs considered suitable for removal were eligible to participate in this trial. Fluorescein was intravenously injected at a dose of 5 to 10 mg/kg...
January 1, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28973406/targeting-accuracy-of-the-subthalamic-nucleus-in-deep-brain-stimulation-surgery-comparison-between-3-t-t2-weighted-magnetic-resonance-imaging-and-microelectrode-recording-results
#17
Andreas Nowacki, Ines Debove, Michael Fiechter, Frédéric Rossi, Markus Florian Oertel, Roland Wiest, Michael Schüpbach, Claudio Pollo
BACKGROUND: Targeting accuracy in deep brain stimulation (DBS) surgery can be defined as the level of accordance between selected and anatomic real target reflected by characteristic electrophysiological results of microelectrode recording (MER). OBJECTIVE: To determine the correspondence between the preoperative predicted target based on modern 3-T magnetic resonance imaging (MRI) and intraoperative MER results separately on the initial and consecutive second side of surgery...
August 2, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28894932/genomic-insights-into-temperature-dependent-transcriptional-responses-of-kosmotoga-olearia-a-deep-biosphere-bacterium-that-can-grow-from-20-to-79%C3%A2-%C3%A2-c
#18
Stephen M J Pollo, Abigail A Adebusuyi, Timothy J Straub, Julia M Foght, Olga Zhaxybayeva, Camilla L Nesbø
Temperature is one of the defining parameters of an ecological niche. Most organisms thrive within a temperature range that rarely exceeds ~30 °C, but the deep subsurface bacterium Kosmotoga olearia can grow over a temperature range of 59 °C (20-79 °C). To identify genes correlated with this flexible phenotype, we compared transcriptomes of K. olearia cultures grown at its optimal 65 °C to those at 30, 40, and 77 °C. The temperature treatments affected expression of 573 of 2224 K. olearia genes. Notably, this transcriptional response elicits re-modeling of the cellular membrane and changes in metabolism, with increased expression of genes involved in energy and carbohydrate metabolism at high temperatures and up-regulation of amino acid metabolism at lower temperatures...
November 2017: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/28843016/directional-leads-for-deep-brain-stimulation-opportunities-and-challenges
#19
W M Michael Schüpbach, Stéphan Chabardes, Cordula Matthies, Claudio Pollo, Frank Steigerwald, Lars Timmermann, Veerle Visser Vandewalle, Jens Volkmann, P Richard Schuurman
No abstract text is available yet for this article.
August 26, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28801098/synthesis-and-in-vitro-evaluation-of-ca-2-channel-blockers-1-4-dihydropyridines-analogues-against-trypanosoma-cruzi-and-leishmania-amazonensis-sar-analysis
#20
Luiz A E Pollo, Milene H de Moraes, Júlia Cisilotto, Tânia B Creczynski-Pasa, Maique W Biavatti, Mario Steindel, Louis P Sandjo
Drugs containing the1,4-dihydropyridine (DHP) core have recently attracted attention concerning their antiparasitic effect against various species of Leishmania and Trypanosoma. This approach named drugs repositioning led to interesting results, which have prompted us to prepare 21 DHP's analogues. The 1,4-DHP scaffold was decorated with different function groups at tree points including the nitrogen atom (NH and N-phenyl), the aryl group attached to C-4 (various substituted aryl residues) and the carbon atoms 2 and 6 (bearing Ph or Me groups)...
December 2017: Parasitology International
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