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Francesca T Cannizzo, Sara Pegolo, Paola Pregel, Elisabetta Manuali, Sonia Salamida, Sara Divari, Frine E Scaglione, Enrico Bollo, Bartolomeo Biolatti, Luca Bargelloni
In livestock production corticosteroids are licensed only for therapy, nevertheless they are often illegally used as growth promoters. The aim of this study was to identify morphological or biomolecular alterations induced by prednisolone (PDN) in experimentally treated beef cattle, since PDN and its metabolites are no longer detectable by LC-MS/MS methods in biological fluids. Moreover, PDN do not induce any histological alterations in thymus, differently from Dexamethasone treatments. Therefore, a marker of illicit treatment for this growth promoter could be useful...
October 14, 2016: Journal of Agricultural and Food Chemistry
Robert J Bollo
No abstract text is available yet for this article.
July 2016: Translational pediatrics
Katrina Ducis, Jian Guan, Michael Karsy, Robert J Bollo
Epilepsy is a common disease in the pediatric population, and the majority of cases are controlled with medications and lifestyle modification. For the children whose seizures are pharmacoresistant, continued epileptic activity can have a severely detrimental impact on cognitive development. Early referral of children with drug-resistant seizures to a pediatric epilepsy surgery center for evaluation is critical to achieving optimal patient outcomes. There are several components to a thorough presurgical evaluation, including a detailed medical history and physical examination, noninvasive testing including electroencephalogram, magnetic resonance imaging (MRI) of the brain, and often metabolic imaging...
July 2016: Translational pediatrics
Carlos Rodriguez-Otero Luppi, Eduardo M Targarona Soler, Carmen Balague Ponz, Juan Pablo Pantoja Millán, Victor Turrado Rodriguez, Jose Luis Pallares Segura, Jesus Bollo Rodriguez, Manel Trias Folch
BACKGROUND: We aimed to develop a grading system based on preoperative parameters that would predict surgical difficulty and morbidity in elective laparoscopic splenectomy. STUDY DESIGN: We retrospectively assessed morbidity in 439 patients who underwent laparoscopic splenectomy for benign and malignant disorders between 1993 and 2013. Medical and surgical records were reviewed and analyzed. We compared preoperative data concerning demographic, clinical, pathological, anatomical, laboratory, and radiological factors with three surgical outcomes: operative time, intraoperative bleeding, and surgical conversion...
August 19, 2016: World Journal of Surgery
Belén Martin Arnau, Víctor Turrado Rodriguez, Ernesto Tartaglia, Jesús Bollo Rodriguez, Eduardo M Targarona, Manuel Trias Folch
INTRODUCTION: Laparoscopic splenectomy (LS) is the preferred treatment of idiopathic thrombocytopenic purpura (ITP) when medical treatment fails. The objective was to evaluate the feasibility and safety of LS according to the preoperative platelet count. METHODS: This study is a retrospective analysis of a series of 199 patients who underwent LS for ITP from 1993 to 2015. The patients were divided into 3 groups according to platelet count: group i (<10×10(9)/L), group ii (10-50×10(9)/L) and group iii (> 50×10(9)/L)...
August 2016: Cirugía Española
Vijay M Ravindra, Michael Karsy, Richard H Schmidt, Philipp Taussky, Min S Park, Robert J Bollo
The authors report the case of a previously healthy 6-month-old girl who presented with right arm and leg stiffening consistent with seizure activity. An initial CT scan of the head demonstrated acute subarachnoid hemorrhage in the basal cisterns extending into the left sylvian fissure. Computed tomography angiography demonstrated a 7 × 6 × 5-mm saccular aneurysm of the inferior M2 division of the left middle cerebral artery. The patient underwent left craniotomy and microsurgical clip ligation with wrapping of the aneurysm neck because the vessel appeared circumferentially dysplastic in the region of the aneurysm...
July 1, 2016: Journal of Neurosurgery. Pediatrics
Yanan Chen, Deborah M Holstein, Sofia Aime, Mariana Bollo, James D Lechleiter
The Ca(2+)-dependent phosphatase, calcineurin (CN) is thought to play a detrimental role in damaged neurons; however, its role in astrocytes is unclear. In cultured astrocytes, CNβ expression increased after treatment with a sarco/endoplasmic reticulum Ca(2+)-ATPase inhibitor, thapsigargin, and with oxygen and glucose deprivation, an in vitro model of ischemia. Similarly, CNβ was induced in astrocytes in vivo in two different mouse models of brain injury - photothrombotic stroke and traumatic brain injury (TBI)...
October 2016: Neurobiology of Disease
Vijay M Ravindra, Robert Bollo, Walavan Sivakumar, Hassan Akbari, Robert P Naftel, David D Limbrick, Andrew Jea, Stephen R Gannon, Chevis Shannon, Yekaterina Birkas, George L Yang, Colin T Prather, John Kestle, Jay Riva-Cambrin
Risk factors for blunt cerebrovascular injury (BCVI) may differ between children and adults, suggesting that children at low risk for BCVI after trauma receive unnecessary computed tomography angiography (CTA) and high-dose radiation. We previously developed a score for predicting pediatric BCVI based on retrospective cohort analysis. Our objective is to externally validate this prediction score with a retrospective multi-institutional cohort. We included patients who underwent CTA for traumatic cranial injury at four pediatric level-one trauma centers...
June 13, 2016: Journal of Neurotrauma
Nuria M Novoa, Maria Teresa Gómez, María Rodríguez, Marcelo F Jiménez López, Jose L Aranda, Elena Bollo de Miguel, Florentino Diez, Jesús Hernández Hernández, Gonzalo Varela
OBJECTIVE: The aim of this study is analysing the impact of the systematic versus occasional videoconferencing discussion of patients with two respiratory referral units along 6 years of time over the efficiency of the in-person outpatient clinics of a thoracic surgery service. METHOD: Retrospective and comparative study of the evaluated patients through videoconferencing and in-person first visits during two equivalents periods of time: Group A (occasional discussion of cases) between 2008-2010 and Group B (weekly regular discussion) 2011-2013...
May 18, 2016: Archivos de Bronconeumología
Frine Eleonora Scaglione, Francesca Tiziana Cannizzo, Paola Pregel, Anton David Perez Rodriguez, Enrico Bollo
Haemoparasites and their effects on hooded crows (Corvus corone cornix) are poorly studied. The aims are to evaluate the prevalence of Haemoproteus spp./Plasmodium spp. or Leucocytozoon spp., to correlate this with gross and histopathological findings, and to investigate the association among infection and geographical origin, age, gender, parasite distribution and prevalence among organs. Hooded crows (n = 47) were collected within a regional culling programme from 3 districts in the province of Turin (Italy) and subjected to necropsy...
September 30, 2016: Veterinaria Italiana
Walavan Sivakumar, Heather S Spader, Eric Scaife, Robert J Bollo
The authors present the first case of a Cushing ulcer in an infant with medulloblastoma who, despite being administered stress ulcer prophylaxis, worsened after corticosteroids were initiated. An 8-month-old boy presented with progressive vomiting, lethargy, and decreased oral intake. Imaging revealed a heterogeneous fourth ventricular mass. Preoperatively, the patient was started on dexamethasone. The patient underwent an uncomplicated external ventricular drain placement and suboccipital craniotomy for resection of the lesion...
April 2016: Translational pediatrics
Michael Karsy, Jian Guan, Katrina Ducis, Robert J Bollo
In the approximately 1% of children affected by epilepsy, pharmacoresistance and early age of seizure onset are strongly correlated with poor cognitive outcomes, depression, anxiety, developmental delay, and impaired activities of daily living. These children often require multiple surgical procedures, including invasive diagnostic procedures with intracranial electrodes to identify the seizure-onset zone. The recent development of minimally invasive surgical techniques, including stereotactic electroencephalography (SEEG) and MRI-guided laser interstitial thermal therapy (MRgLITT), and new applications of neurostimulation, such as responsive neurostimulation (RNS), are quickly changing the landscape of the surgical management of pediatric epilepsy...
April 2016: Translational pediatrics
Jian Guan, Michael Karsy, Katrina Ducis, Robert J Bollo
Pediatric epilepsy is a debilitating condition that impacts millions of patients throughout the world. Approximately 20-30% of children with recurrent seizures have drug-resistant epilepsy (DRE). For these patients, surgery offers the possibility of not just seizure freedom but significantly improved neurocognitive and behavioral outcomes. The spectrum of surgical options is vast, ranging from outpatient procedures such as vagus nerve stimulation to radical interventions including hemispherectomy. The thread connecting all of these interventions is a common goal-seizure freedom, an outcome that can be achieved safely and durably in a large proportion of patients...
April 2016: Translational pediatrics
Heather S Spader, Robert J Bollo, Christian A Bowers, Jay Riva-Cambrin
OBJECTIVE Intrathecal baclofen infusion systems to manage severe spasticity and dystonia are associated with higher infection rates in children than in adults. Factors unique to this population, such as poor nutrition and physical limitations for pump placement, have been hypothesized as the reasons for this disparity. The authors assessed potential risk factors for infection in a multivariate analysis. METHODS Patients who underwent implantation of a programmable pump and intrathecal catheter for baclofen infusion at a single center between January 1, 2000, and March 1, 2012, were identified in this retrospective cohort study...
June 2016: Journal of Neurosurgery. Pediatrics
Rosa Cordovilla, Elena Bollo de Miguel, Ana Nuñez Ares, Francisco Javier Cosano Povedano, Inmaculada Herráez Ortega, Rafael Jiménez Merchán
Hemoptysis is the expectoration of blood from the tracheobronchial tree. It is commonly caused by bronchiectasis, chronic bronchitis, and lung cancer. The expectorated blood usually originates from the bronchial arteries. When hemoptysis is suspected, it must be confirmed and classified according to severity, and the origin and cause of the bleeding determined. Lateral and AP chest X-ray is the first study, although a normal chest X-ray does not rule out the possibility of malignancy or other underlying pathology...
July 2016: Archivos de Bronconeumología
F E Scaglione, F T Cannizzo, L Chiappino, A Sereno, M Ripepi, S Salamida, E Manuali, E Bollo
Blood parasites infect all vertebrates (Clayton and Moore 1997). Avian malaria parasites (Plasmodium spp., Plasmodiidae) are cosmopolitan in their distribution and are responsible for severe diseases in domestic and wild birds.In September 2009, nine raptorial birds that either arrived recently or were maintained as permanent residents at the Safaripark Pombia (northwest Italy) showed loss of stamina, developing listlessness, anorexia and regurgitation. Within one month three animals died and were necropsied...
February 2016: Research in Veterinary Science
Shimelis Dagnachew, Getachew Terefe, Getachew Abebe, Asegedech Sirak, Enrico Bollo, Dave Barry, Bruno Goddeeris
BACKGROUND: The Northwest region of Ethiopia is affected by both tsetse and non-tsetse transmitted trypanosomosis with a huge impact on livestock productivity. The objective of this experimental study was to determine clinical and pathological findings in young Zebu cattle experimentally infected with Trypanosoma vivax isolates from tsetse infested and non-tsetse infested areas of Northwest Ethiopia. A total of 18 cattle (Bos indicus) aged between 6 and 12 months, purchased from a trypanosome-free and confirmed to be trypanosome negative divided into three groups of six animals were used...
2015: BMC Veterinary Research
Felipe Oyarzun-Ampuero, Ariel Guerrero, Natalia Hassan-Lopez, Javier O Morales, Soledad Bollo, Alejandro Corvalan, Andrew F G Quest, Marcelo J Kogan
Organic and inorganic nanoparticles show great potential for cancer diagnosis and treatment. Because gastric cancer (GC) represents the second most deadly type of neoplasia worldwide, continued research efforts by scientists and clinicians are essential to improve diagnosis and treatment. This paper reviews significant findings in the area of nanoparticles (organic and inorganic origin) that may aid in prevention and diagnosis of GC. This review focuses in the first section on H. pylori and the connection to GC, highlighting nanoformulations designed to control bacterial growth...
2015: Current Pharmaceutical Design
Víctor Turrado-Rodriguez, Eduard Targarona Soler, Jesús Manuel Bollo Rodriguez, Carmen Balagué Ponz, Pilar Hernández Casanovas, Carmen Martínez, Manel Trías Folch
BACKGROUND: There is an extended belief that the laparoscopic approach to left colectomy (LC) is technically more demanding and associated with more postoperative complications than to right colectomy (RC). However, there is no consensus in the literature about whether the short-term outcomes of RC differ from those of LC. The aim of this paper was to compare the postoperative course of patients undergoing RC and LC. METHODS: We retrospectively analyzed 1000 consecutive patients who underwent a laparoscopic RC or LC between 1998 and 2012...
April 2016: Surgical Endoscopy
Vijay M Ravindra, Marcus D Mazur, Carrie A Mohila, Matthew T Sweney, Aimee Hersh, Robert J Bollo
PURPOSE: Rasmussen encephalitis without seizures is rare. We report a case of Rasmussen encephalitis and cortical dysplasia without epilepsy as well as describe the imaging, pathology, and clinical course and review the literature to investigate whether this may represent a rare subset of Rasmussen encephalitis. CASE REPORT: We report the case of a 12-year-old girl with a history of cognitive decline and right arm weakness. Magnetic resonance imaging demonstrated diffuse left hemispheric cortical and subcortical atrophy suggestive of Rasmussen encephalitis...
November 2015: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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