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metabolic syndrome and erectile dysfunction

Benoît Peyronnet, Thomas Seisen, Véronique Phé, Vincent Misrai, Alexandre de la Taille, Morgan Rouprêt
AIM: To provide a systematic review of epidemiological data regarding the association between erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) in men. SEARCH STRATEGY: A research has been conducted on the Medline database using the keywords: ("erectile dysfunction" or "sexual dysfunction") and ("benign prostatic hyperplasia" or "lower urinary tract symptoms"). The eligibility of studies was defined using the PICOS method in accordance with the PRISMA statement...
October 10, 2016: La Presse Médicale
P Cuny, M Houot, S Ginisty, S Horowicz, F Plassart, H Mentec, P Eftekhari
INTRODUCTION: The aim of this paper is to underline the need for systematic monitoring of patients treated with anticholinergic antipsychotic drugs. We present the clinical history of a 34-year-old adult, treated with quetiapine in combination with other drugs with anticholinergic effects. CASE REPORT: A 34-year-old male adult had been suffering from bipolar disorder since 2001. He was treated with risperidone, but he was not compliant due to adverse effects, including decreased libido and erectile dysfunction...
September 13, 2016: L'Encéphale
Kenneth J DeLay, Nora Haney, Wayne Jg Hellstrom
Erectile dysfunction (ED) is prevalent among men and its presence is often an indicator of systemic disease. Risk factors for ED include cardiovascular disease, hypertension, diabetes mellitus (DM), tobacco use, hyperlipidemia, hypogonadism, lower urinary tract symptoms, metabolic syndrome, and depression. Addressing the modifiable risk factors frequently improves a patient's overall health and increases lifespan. The literature suggests that smoking cessation, treatment of hyperlipidemia, and increasing physical activity will improve erectile function in many patients...
August 2016: World Journal of Men's Health
Kutan Ozer, Mustafa Ozan Horsanali, Sacit Nuri Gorgel, Burcu Ozalp Horsanali, Emin Ozbek
AIM: There is a large body of evidence of clinical studies regarding the relation between metabolic syndrome (MetS) and benign prostatic hyperplasia (BPH)-related lower urinary tract symptoms (LUTS) in men. A possible link between inflammation and these 2 clinical entities has also been proposed. Here, we aimed at evaluating the role of neutrophil-lymphocyte ratio (NLR), an indicator of inflammation and MetS, in the pathogenesis of LUTS and other BPH-related parameters. METHOD: We evaluated 244 patients with benign prostate hyperplasia admitted to our outpatient clinic between January 2014 and June 2015...
July 28, 2016: Urologia Internationalis
Geoff Hackett, Michael Krychman, David Baldwin, Nelson Bennett, Ahmed El-Zawahry, Alessandra Graziottin, Monika Lukasiewicz, Kevin McVary, Yoshikazu Sato, Luca Incrocci
Erectile dysfunction (ED) has been well recognized as a marker of increased cardiovascular risk for more than 15 years, especially in younger men. Early detection of ED represents an opportunity to intervene to decrease the risk of future cardiovascular events and limit the progression of ED severity. Evidence suggests there is a window of opportunity of 3 to 5 years from the onset of ED to subsequent cardiovascular events. This opportunity is usually missed if the onus is placed on the patient to seek care for his sexual problems...
June 2016: Journal of Sexual Medicine
Faysal A Yafi, Lawrence Jenkins, Maarten Albersen, Giovanni Corona, Andrea M Isidori, Shari Goldfarb, Mario Maggi, Christian J Nelson, Sharon Parish, Andrea Salonia, Ronny Tan, John P Mulhall, Wayne J G Hellstrom
Erectile dysfunction is a multidimensional but common male sexual dysfunction that involves an alteration in any of the components of the erectile response, including organic, relational and psychological. Roles for nonendocrine (neurogenic, vasculogenic and iatrogenic) and endocrine pathways have been proposed. Owing to its strong association with metabolic syndrome and cardiovascular disease, cardiac assessment may be warranted in men with symptoms of erectile dysfunction. Minimally invasive interventions to relieve the symptoms of erectile dysfunction include lifestyle modifications, oral drugs, injected vasodilator agents and vacuum erection devices...
2016: Nature Reviews. Disease Primers
Juraj Fillo, Michaela Levcikova, Martina Ondrusova, Jan Breza, Peter Labas
The aim of the current study was to investigate the influence of different grades of abdominal obesity (AO) on the prevalence of testosterone deficiency syndrome (TDS), erectile dysfunction (ED), and metabolic syndrome (MetS). In a cross-sectional descriptive study, a total of 216 males underwent a complete urological, internal, and hormonal evaluation. Males were divided according to waist circumference into five groups: less than 94 cm (Grade [G] 0), 94 to 101 cm (G1), 102 to 109 cm (G2), 110 to 119 cm (G3), and more than 120 cm (G4)...
May 16, 2016: American Journal of Men's Health
Pilar Ángeles Oriol Torón, Teresa Badía Farré, Amparo Romaguera Lliso, Jovita Roda Diestro
AIMS: To ascertain the prevalence of metabolic syndrome (MS) in patients with peripheral artery disease (PAD) at the Martorell primary care (PC) center. To analyze the differences in comorbidities and cardiovascular risk factors between patients with PAD with and without MS. METHODS: A cross-sectional, descriptive study on patients diagnosed with PAD according to computerized clinical records of the Martorell PC center. Variables collected included age, sex, high blood pressure (HBP), dyslipidemia (DLP), diabetes (DM), smoking, obesity, cardiovascular disease (CVD), erectile dysfunction (ED), renal failure (RF), and oligoalbuminuria...
June 2016: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
Ridwan Shabsigh, Andreas Mattern
INTRODUCTION: Erectile dysfunction (ED) is prevalent in men with metabolic syndrome (MetS); therefore, it is important to characterize ED treatments in this population. AIMS: To investigate the safety and effectiveness of vardenafil in men with ED and MetS in a clinical setting. METHODS: REVITALISE is an international, prospective, single-arm, observational study in men with ED and MetS newly prescribed vardenafil. Vardenafil was prescribed at the discretion of the treating physician in line with the marketing authorization...
September 2016: Sexual Medicine
Alexandra Kautzky-Willer, Heidemarie Abrahamian, Raimund Weitgasser, Peter Fasching, Fritz Hoppichler, Monika Lechleitner
Metabolic diseases dramatically affect life of men and women from infancy up to old age and are a major challenge for clinicians. Health professionals are confronted with different needs of women and men. This article aims at an increase of gender awareness and the implementation of current knowledge of gender medicine in daily clinical practice with regard to pre-diabetes and diabetes. Sex and gender affect screening and diagnosis of metabolic diseases as well as treatment strategies and outcome. Impaired glucose and lipid metabolism, regulation of energy balance and body fat distribution are related to steroid hormones and therefore impose their influence on cardiovascular health in both men and women...
April 2016: Wiener Klinische Wochenschrift
Rakesh Kumar Chaudhary, Bilal Haider Shamsi, Tan Tan, Hui-Ming Chen, Jun-Ping Xing
AIM: To study the relationship between erectile dysfunction and type 2 diabetes mellitus (T2DM)/metabolic syndrome (MetS). METHODS: This prospective study invited male patients with T2DM attending for a routine outpatient check-up to complete two questionnaires. A general questionnaire was used to collect demographic and clinical characteristics, while sexual function was assessed using the International Index of Erectile Function scoring system. The prevalence of MetS in this patient population was determined using information from the general questionnaire...
June 2016: Journal of International Medical Research
Alberto Verrotti, Elisabetta Mencaroni, Marta Cofini, Miriam Castagnino, Antonio Leo, Emilio Russo, Vincenzo Belcastro
BACKGROUND: Valproic acid (VPA) is a broad spectrum antiepileptic drug (AED) that is generally regarded as a first-choice agent for most forms of idiopathic and symptomatic generalised epilepsies. Available data suggest that menstrual disorders and certain endocrine manifestations of reproductive system disorders may be more common in women treated with VPA than in those treated with other AEDs. METHODS: A PubMed search for MEDLINE was undertaken to look for studies using the terms "VPA metabolism", "VPA and sexual functions in men", "VPA and sexual functions in women" and "VPA metabolism and endocrine disorders" as key words...
2016: Current Drug Metabolism
Marie-Astrid Denys, Ralf Anding, Andrea Tubaro, Paul Abrams, Karel Everaert
AIMS: To investigate the link between lower urinary tract symptoms (LUTS) and metabolic disorders. MATERIALS AND METHODS: This report results from presentations and subsequent discussions about LUTS and metabolic disorders at the International Consultation on Incontinence Research Society (ICI-RS) in Bristol, 2014. RESULTS: There are common pathophysiological determinants for the onset of LUTS and the metabolic syndrome (MetS). Both conditions are multifactorial, related to disorders in circadian rhythms and share common risk factors...
February 2016: Neurourology and Urodynamics
Deniz Güney Duman, Ercan Biçakci, Çiğdem Ataizi Çelikel, Cem Akbal
INTRODUCTION: Nonalcoholic fatty liver disease (NAFLD) is considered the hepatic manifestation of metabolic syndrome (MetS). Although the link between MetS and erectile dysfunction (ED) is well known, clinical studies investigating the association between NAFLD and ED are scant. AIM: To evaluate the relationship between NAFLD and ED. METHODS: Male patients with biopsy-proven NAFLD were prospectively asked to fill the five-item International Index of Erectile Function (IIEF-5) questionnaire...
March 2016: Journal of Sexual Medicine
Fouad Aoun, Simone Albisinni, Anthony Kallas Chemaly, Marc Zanaty, Thierry Roumeguère
The evidence for the existence of a common pathway for health issues in men is presented in this review. Several epidemiological studies have shown that conditions like cardiovascular diseases (CVD), metabolic syndrome, diabetes, lower urinary tract symptom (LUTS), erectile dysfunction (ED), prostate cancer, hypogonadism, depression and suicide can be associated as risk factors for each other. Thus, the risk of CVD is significantly increased in men with metabolic syndrome, ED, hypogonadism, prostate cancer and/or LUTS...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
T A Jepps, S P Olesen, I A Greenwood, T Dalsgaard
BACKGROUND AND PURPOSE: KCNQ-encoded voltage-dependent potassium channels (Kv 7) are involved in the regulation of vascular tone. In this study we evaluated the influence of Kv 7 channel activation on smooth muscle relaxation in rat penile arteries and corpus cavernosum from normal and spontaneously hypertensive, heart failure-prone (SHHF) rats - a rat model of human metabolic syndrome. EXPERIMENTAL APPROACH: Quantitative PCR and immunohistochemistry were used to determine the expression of KCNQ isoforms in penile tissue...
May 2016: British Journal of Pharmacology
Paolo Capogrosso, Francesco Montorsi, Andrea Salonia
PURPOSE OF REVIEW: This article summarizes current findings supporting the role of erectile dysfunction as a proxy of general health status, with a focus on the young population. RECENT FINDINGS: Erectile dysfunction has been historically associated to increased cardiovascular risk and mortality. Several studies supported the role of erectile dysfunction as a predictive factor of subsequent cardiovascular events, acquiring significant importance even in young men...
March 2016: Current Opinion in Urology
Huai-Ching Tai, Hong-Jeng Yu
Metabolic syndrome (MS) and lower urinary tract symptoms (LUTS) are both highly prevalent problems of public health in the modern era. MS has been demonstrated to increase the risks for developing cardiovascular, kidney and liver diseases, and recent epidemiological evidences have indicated a possible link between MS and urological diseases, such as erectile dysfunction (ED) in men and LUTS in both sexes. The relationship between MS and LUTS was first described by Hammarsten et al. and concluded that men with MS risk factors had a larger prostate volume and a faster growth rate...
March 2012: Lower Urinary Tract Symptoms
G Antonini, G M Busetto, E De Berardinis, R Giovannone, P Vicini, F Del Giudice, S L Conti, V Gentile, P E Perito
Erectile dysfunction (ED), the second most common male sexual disorder, has an important impact on man sexuality and quality of life affecting also female partner's sexual life. ED is usually related to cardiovascular disease or is an iatrogenic cause of pelvic surgery. Many non-surgical treatments have been developed with results that are controversial, while surgical treatment has reached high levels of satisfaction. The aim is to evaluate outcomes and complications related to prosthesis implant in patients suffering from ED not responding to conventional medical therapy or reporting side effects with such a therapy...
January 2016: International Journal of Impotence Research
Giulia Rastrelli, Giovanni Corona, Edoardo Mannucci, Mario Maggi
INTRODUCTION: Vascular age, as derived from the SCORE project algorithm for cardiovascular (CV) risk estimation, is an effective way for communicating CV risk. However, studies on its clinical correlates are scanty. AIM: To evaluate if the difference between vascular and chronological age (Δage), in a population of subjects with erectile dysfunction (ED), can identify men with a worse risk profile. METHODS: A consecutive series of 2,853 male patients attending the outpatient clinic for erectile dysfunction (ED) for the first time was retrospectively studied...
December 2015: Journal of Sexual Medicine
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