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metabolic syndrome and erectile dysfunction

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https://www.readbyqxmd.com/read/28700893/coronary-microvascular-disease-as-an-early-culprit-in-the-pathophysiology-of-diabetes-and-metabolic-syndrome
#1
REVIEW
Hicham Labazi, Aaron J Trask
Metabolic syndrome (MetS) is a group of cardio-metabolic risk factors that includes obesity, insulin resistance, hypertension, and dyslipidemia; these are also a combination of independent coronary artery disease (CAD) risk factors. Alarmingly, the prevalence of MetS risk factors are increasing and a leading cause for mortality. In the vasculature, complications from MetS and type 2 diabetes (T2D) can be divided into microvascular (retinopathy and nephropathy) and macrovascular (cardiovascular diseases and erectile dysfunction)...
July 9, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28650864/metabolic-syndrome-and-sexual-dysfunction
#2
Michael L Schulster, Sydney E Liang, Bobby B Najari
PURPOSE OF REVIEW: To describe the connection between metabolic syndrome and male sexual dysfunction. RECENT FINDINGS: Concurrent with the obesity epidemic, metabolic syndrome in the United States is reaching crisis levels. A myriad of comorbidities are rising as well, affecting cost and quality of life. Sexual dysfunction is one of these comorbidities, with an extremely high prevalence, which will only increase as the population ages.In light of this ubiquity, recent research has explored the mechanisms of decreased libido, hypogonadism and erectile dysfunction through the lens of metabolic syndrome and its individual components...
September 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28595561/sexual-dysfunction-cardiovascular-risk-and-effects-of-pharmacotherapy
#3
Konstantinos P Imprialos, Konstantinos Stavropoulos, Michael Doumas, Konstantinos Tziomalos, Asterios Karagiannis, Vasilios G Athyros
Sexual dysfunction affects millions of people with an increasing prevalence, worldwide. The pathophysiology of the disease shares several similarities with cardiovascular disease (CVD), including atherosclerosis, endothelial dysfunction, structural vascular damage and subclinical inflammation. Erectile dysfunction (ED) and female sexual dysfunction are common among patients with CVD and risk factors such as hypertension, diabetes, obesity and metabolic syndrome. Given the common pathogenesis of the diseases, ED is an independent prognostic factor of future ED events...
June 9, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28540224/erectile-dysfunction-therapy-in-countries-where-implant-is-economically-not-feasible
#4
REVIEW
Adrián M Garza-Gangemi, Mariano Sotomayor-de Zavaleta
Erectile dysfunction (ED), a frequent complaint in the primary care setting, is strongly associated with obesity, cigarette smoking and other common cardiovascular risk factors like hypertension, diabetes mellitus (DM), lipid disorders and the metabolic syndrome. The prevalence of these cardiovascular disorders is rising at staggering rates in most Latin American countries. ED is a symptom that mainly affects economically productive men (40-70 years of age) potentially causing major psychosocial repercussions and reduced quality of life...
April 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28412335/metabolic-syndrome-does-not-increase-the-risk-of-ejaculatory-dysfunction-in-patients-with-lower-urinary-tract-symptoms-and-benign-prostatic-enlargement-an-italian-single-center-cohort-study
#5
Cosimo De Nunzio, Riccardo Lombardo, Mauro Gacci, Antonio Nacchia, Fabrizio Presicce, Hassan Alkhatatbeh, Sergio Serni, Andrea Tubaro
OBJECTIVE: To evaluate the relationship between metabolic syndrome (MetS) and ejaculatory dysfunction (EjD) in patients with lower urinary tract symptoms and benign prostatic enlargement. MATERIALS AND METHODS: From 2012 to 2016, a consecutive series of men with lower urinary tract symptoms and benign prostatic enlargement who were attending our prostate clinic were evaluated using the International Prostate Symptom Score (IPSS) and were subsequently enrolled into a prospective database...
April 13, 2017: Urology
https://www.readbyqxmd.com/read/28390836/prevalence-of-metabolic-syndrome-and-its-association-with-lower-urinary-tract-symptoms-and-sexual-function
#6
M Plata, J I Caicedo, C G Trujillo, Á M Mariño-Alvarez, N Fernandez, A Gutierrez, F Godoy, M Cabrera, J G Cataño-Cataño, D Robledo
OBJECTIVES: To estimate the frequency of metabolic syndrome (MetS) in a daily urology practice and to determine its association with lower urinary tract symptoms (LUTS) and erectile dysfunction (ED). MATERIAL AND METHODS: A retrospective study was conducted. Data from all male patients aged ≥40 years who attended our outpatient urology clinic from 2010 to 2011 was collected. Prevalence of MetS was determined, and LUTS and ED were assessed. A logistic model was used to determine possible associations, controlling for confounders and interaction factors...
April 5, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28367661/increased-prevalence-of-premature-ejaculation-in-men-with-metabolic-syndrome
#7
Nader Salama, Ahmed Eid, Ahmed Swedan, Alaa Hatem
This prospective study aimed to investigate the relationship between metabolic syndrome (Met S) and premature ejaculation (PE) among men. The study included 300 consecutive male patients (53.6 y ± 8.7) who attended the urology clinic (December 2013-September 2014), mostly complaining of renal/ureteric calculi. A diagnostic approach was undertaken to include demographics, clinical features and laboratory investigations of the study subjects. Both erectile function and PE were evaluated using the International Index of Erectile Function (abridged form, IIEF-5) and Premature Ejaculation Diagnostic Tool (PEDT) questionnaires, respectively...
June 2017: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
https://www.readbyqxmd.com/read/28364864/evaluation-of-the-efficacy-and-safety-of-tribulus-terrestris-in-male-sexual-dysfunction-a-prospective-randomized-double-blind-placebo-controlled-clinical-trial
#8
RANDOMIZED CONTROLLED TRIAL
Zdravko Kamenov, Svetlana Fileva, Krassimir Kalinov, Emmanuele A Jannini
OBJECTIVE: The primary objectives were to compare the efficacy of extracts of the plant Tribulus terrestris (TT; marketed as Tribestan), in comparison with placebo, for the treatment of men with erectile dysfunction (ED) and with or without hypoactive sexual desire disorder (HSDD), as well as to monitor the safety profile of the drug. The secondary objective was to evaluate the level of lipids in blood during treatment. PARTICIPANTS AND DESIGN: Phase IV, prospective, randomized, double-blind, placebo-controlled clinical trial in parallel groups...
May 2017: Maturitas
https://www.readbyqxmd.com/read/28325476/erectile-dysfunction-in-patients-with-nonalcoholic-fatty-liver-disease
#9
Ahmad Farooq Alsayed Hasanain, Reem Ezzat Mahdy, Ali Mohamed Abdel-Rahman Mahran, Ahmed Serag Mahmoud Safwat, Asmaa Omar Mohamed, Sherif Mohamed Abdel-Aal
BACKGROUND AND STUDY AIMS: There is a lack of studies on erectile dysfunction (ED) in patients diagnosed with nonalcoholic fatty liver disease (NAFLD). The present study aimed to estimate the prevalence of ED in patients with NAFLD and to determine the independent predictors of ED in these patients. PATIENTS AND METHODS: We conducted a prospective, hospital-based study of 192 consecutive male patients with NAFLD. All patients underwent clinical evaluation; abdominal ultrasonography; test for viral hepatitis markers; and estimation of liver chemistry panel, complete blood count, prothrombin time, serum lipids panel, serum testosterone, and fasting serum levels of glucose, insulin, and C-peptide...
March 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/28295481/effects-of-taking-tadalafil-5%C3%A2-mg-once-daily-on-erectile-function-and-total-testosterone-levels-in-patients-with-metabolic-syndrome
#10
L Ozcan, E C Polat, R Kocaaslan, E Onen, A Otunctemur, E Ozbek
We aimed to evaluate the efficacy of tadalafil 5 mg once-daily treatment on testosterone levels in patients with erectile dysfunction (ED) accompanied by the metabolic syndrome. A total of 40 men with metabolic syndrome were evaluated for ED in this study. All the patients received 5 mg tadalafil once a day for 3 months. Erectile function was assessed using the five-item version of the International Index of Erectile Function (IIEF) questionnaire. Serum testosterone, follicle-stimulating hormone and luteinising hormone levels were also evaluated, and blood samples were taken between 08...
March 15, 2017: Andrologia
https://www.readbyqxmd.com/read/28280316/the-impact-of-hypomagnesemia-on-erectile-dysfunction-in-elderly-non-diabetic-stage-3-and-4-chronic-kidney-disease-patients-a-prospective-cross-sectional-study
#11
Omer Toprak, Yasin Sarı, Akif Koç, Erhan Sarı, Ali Kırık
BACKGROUND: Erectile dysfunction (ED) is common in older men with chronic kidney disease. Magnesium is essential for metabolism of nitric oxide which helps in penile erection. There is little information available about the influence of serum magnesium on ED. The aim of the study was to assess the influence of hypomagnesemia on ED in elderly chronic kidney disease patients. SUBJECTS AND METHODS: A total of 372 patients aged 65-85 years, with an estimated glomerular filtration rate of 60-15 mL/min/1...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28267892/the-great-opportunity-of-the-andrological-patient-cardiovascular-and-metabolic-risk-assessment-and-prevention
#12
C Foresta, A Ferlin, A Lenzi, P Montorsi
Andrologists, cardiologists and diabetologists (and general practitioners) have the great opportunity to collaborate and find shared clinical workup for the benefit of a large number of men. Several evidence established a link between erectile dysfunction (ED), cardiovascular disease (CVD), diabetes, and metabolic syndrome. Not only these conditions share many risk factors and pathophysiological mechanisms but also an emerging paradigm indicates that ED is, in fact, an independent marker of cardiovascular disease risk, CV events and CV mortality...
May 2017: Andrology
https://www.readbyqxmd.com/read/28217448/erectile-dysfunction-metabolic-syndrome-and-cardiovascular-risks-facts-and-controversies
#13
REVIEW
Edward Sanchez, Alexander W Pastuszak, Mohit Khera
Erectile dysfunction (ED) is the most common male sexual dysfunction, and shares many risk factors with systemic conditions including cardiovascular disease (CVD) and the metabolic syndrome (MetS). ED is considered to be an independent risk factor for CVD and can be a harbinger of future cardiovascular events. Given this relationship, each encounter for ED should be viewed by healthcare providers as an opportunity to screen for CVD and other comorbid conditions, including the MetS, that can significantly affect a man's overall health...
February 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28078997/lipoprotein-a-and-cardiovascular-risk-the-show-must-go-on
#14
REVIEW
Niki Katsiki, Khalid Al-Rasadi, Dimitri P Mikhailidis
Lipoprotein (a) [Lp(a)] is an independent but moderate, predictor for coronary heart disease (CHD) prevalence and severity. Several established and emerging cardiovascular (CV) risk factors including age, gender, ethnicity, smoking, dyslipidemia, hypertension, obesity, type 2 diabetes mellitus, alcohol consumption, arterial stiffness and hyperuricemia have been linked to Lp(a) metabolism. Apart from CHD, Lp(a) has been also associated with non-cardiac vascular diseases and diseases associated with increased CV risk such as chronic kidney disease, metabolic syndrome, non-alcoholic fatty liver disease, erectile dysfunction, obstructive sleep apnea syndrome, inflammatory bowel diseases and human immunodeficiency virus infection...
2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27929275/erectile-dysfunction
#15
Karl T Rew, Joel J Heidelbaugh
Erectile dysfunction (ED) is the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It is common, affecting at least 12 million U.S. men. The five-question International Index of Erectile Function allows rapid clinical assessment of ED. The condition can be caused by vascular, neurologic, psychological, and hormonal factors. Common conditions related to ED include diabetes mellitus, hypertension, hyperlipidemia, obesity, testosterone deficiency, and prostate cancer treatment...
November 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/27914613/association-between-cardiometabolic-index-and-erectile-dysfunction-a-new-index-for-predicting-cardiovascular-disease
#16
Murat Dursun, Huseyin Besiroglu, Alper Otunctemur, Emin Ozbek
Over the past decade, it has been suggested that erectile dysfunction (ED) is an early indicator of cardiovascular disease. In a recent study, a new index, termed as cardiometabolic index (CMI), was defined and measured as the product of triglyceride (TG)/high-density lipoprotein-cholesterol (HDL-C) ratio and waist-to-height ratio, which are good predictors of coronary artery disease and main components of metabolic syndrome (MetS). All components of the CMI are also included in MetS criteria. Thus, we decided to evaluate the correlation between CMI, including the criteria of MetS, and ED...
December 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27847919/phosphorus-as-predictive-factor-for-erectile-dysfunction-in-middle-aged-men-a-cross-sectional-study-in-korea
#17
Seung Ki Min, Kwibok Choi, Soon Ki Kim, Gyeong In Lee, In-Chang Cho
PURPOSE: High serum inorganic phosphorus level is related with atherosclerosis and an elevated risk of cardiovascular disease. At the same time, the association of phosphorus with erectile dysfunction (ED) is not well reported. We studied the effect of serum phosphorus on ED and the relationship with other clinical variables. MATERIALS AND METHODS: From March to September 2013, 1,899 police men aged 40 to 59 years who entered in a prostate health screening were targeted...
November 2016: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/27801385/a-review-of-metabolic-syndrome-research-in-malaysia
#18
K G Lim, W K Cheah
Seventy-three articles related to metabolic syndrome were found in a search through databases dedicated to indexing all literature with original data involving the Malaysian population between years 2000 and 2015. Metabolic syndrome affects 25 to 40% of adult population of Malaysia with the risk increasing with age. Obese children are also at risk. Indian ethnicity has the highest rates, followed by Malay and chinese. It was found that socioeconomics determinants such as living in urban areas, unemployment, lower income, lower education level and shift workers had higher prevalence of metabolic syndrome...
June 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/27745762/-lower-urinary-tract-symptoms-related-to-benign-prostatic-hyperplasia-and-erectile-dysfunction-a-systematic-review
#19
REVIEW
Benoît Peyronnet, Thomas Seisen, Véronique Phé, Vincent Misrai, Alexandre de la Taille, Morgan Rouprêt
AIM: To provide a systematic review of epidemiological data regarding the association between erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) in men. SEARCH STRATEGY: A research has been conducted on the Medline database using the keywords: ("erectile dysfunction" or "sexual dysfunction") and ("benign prostatic hyperplasia" or "lower urinary tract symptoms"). The eligibility of studies was defined using the PICOS method in accordance with the PRISMA statement...
March 2017: La Presse Médicale
https://www.readbyqxmd.com/read/27637870/-quetiapine-and-anticholinergic-drugs-induced-ischaemic-colitis-a-case-study
#20
P Cuny, M Houot, S Ginisty, S Horowicz, F Plassart, H Mentec, P Eftekhari
INTRODUCTION: The aim of this paper is to underline the need for systematic monitoring of patients treated with anticholinergic antipsychotic drugs. We present the clinical history of a 34-year-old adult, treated with quetiapine in combination with other drugs with anticholinergic effects. CASE REPORT: A 34-year-old male adult had been suffering from bipolar disorder since 2001. He was treated with risperidone, but he was not compliant due to adverse effects, including decreased libido and erectile dysfunction...
September 13, 2016: L'Encéphale
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