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https://www.readbyqxmd.com/read/28090299/tadalafil-therapy-for-sarcoidosis-associated-pulmonary-hypertension
#1
H J Ford, R P Baughman, R Aris, P Engel, J F Donohue
Sarcoidosis-associated pulmonary hypertension (SAPH) is estimated to occur in at least 5% or more of sarcoidosis patients, and it contributes to significant morbidity and mortality. Optimal therapy for SAPH is not well established. We performed a 24-week open-label trial of tadalafil for SAPH at 2 academic medical centers. Subjects were required to have confirmed sarcoidosis plus a right heart catheterization within 12 months of enrollment showing a mean pulmonary artery pressure ≥ 25 mmHg, a pulmonary artery wedge pressure ≤ 15 mmHg, and a calculated pulmonary vascular resistance ≥ 3 Wood units...
December 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/28079667/stage-of-fibrosis-and-portal-pressure-correlation-in-nonalcoholic-steatohepatitis
#2
Achuthan Sourianarayanane, Jyothsna Talluri, Abinav Humar, Arthur J McCullough
BACKGROUND: Hepatic venous pressure gradient (HVPG) measurement correlates with staging of liver fibrosis. Patients with nonalcoholic steatohepatitis (NASH) have a different pattern of fibrosis compared with hepatitis C virus (HCV) with possible alterations in pressures. AIM: The aim of this study was to compare portal pressures with the stage of fibrosis in NASH in comparison with other liver diseases. PATIENTS AND METHODS: Records of all patients who had undergone transjugular liver biopsy with pressure measurements between January 2001 and June 2013 were reviewed...
January 10, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28075434/diagnosis-and-surgical-correction-of-congenital-bilateral-patellar-luxation-in-two-dwarf-zebu-calves
#3
Göknil Kalayci, Cagri Binici, Julia Tünsmeyer, Silke Stein, Ahmad Al Aiyan, Kerstin Müller, Leo Brunnberg
This case study presents two female dwarf zebu calves with permanent bilateral flexion of the stifle joint secondary to bilateral congenital lateral patellar luxation. The patella could be manually repositioned bilaterally in the first calf (14 days old), but re-luxated immediately with release of manual pressure (luxation grade III). In the second calf (28 days old) both patellae were permanently luxated laterally (grade IV). The right and left stifles of each calf were operated in a staged procedure with approximately 14 days between surgery of the two sides...
January 11, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28066621/the-non-intubated-anesthesia-for-airway-surgery
#4
REVIEW
Katsuhiro Okuda, Ryoichi Nakanishi
Surgical treatment for lung cancer including airway resection following reconstruction is typically performed under general anesthesia with single-lung ventilation because it is necessary to maintain a sufficient working space and to adjust the airway pressure for the leak test. However, non-intubated thoracic surgery has been gradually developed in recent years for thoracoscopic surgery, due to its lower rate of postoperative complications, shorter hospitalization duration, and lower invasiveness than the usual single-lung anesthesia...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28062514/cardiopulmonary-exercise-testing-for-detecting-pulmonary-arterial-hypertension-in-systemic-sclerosis
#5
Daniel Dumitrescu, Christian Nagel, Gabor Kovacs, Tom Bollmann, Michael Halank, Jörg Winkler, Martin Hellmich, Ekkehard Grünig, Horst Olschewski, Ralf Ewert, Stephan Rosenkranz
OBJECTIVES: Pulmonary arterial hypertension (PAH) is a devastating disease with limited survival and occurs as a frequent complication in patients with systemic sclerosis (SSc). A definite diagnosis of PAH is obtained by right heart catheterisation (RHC); however, the initial suspicion is raised by non-invasive methods. We assessed the diagnostic accuracy of key parameters derived from cardiopulmonary exercise testing (CPET) for detecting and ruling out SSc-associated PAH. METHODS: In a multicentre setting, we prospectively evaluated 173 consecutive patients with SSc without known PAH, but with clinical suspicion of PAH...
January 6, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28056816/optimization-of-pressure-settings-during-adaptive-servo-ventilation-support-using-real-time-heart-rate-variability-assessment-initial-case-report
#6
Teruhiko Imamura, Daisuke Nitta, Koichiro Kinugawa
BACKGROUND: Adaptive servo-ventilation (ASV) therapy is a recent non-invasive positive pressure ventilation therapy that was developed for patients with heart failure (HF) refractory to optimal medical therapy. However, it is likely that ASV therapy at relatively higher pressure setting worsens some of the patients' prognosis compared with optimal medical therapy. Therefore, identification of optimal pressure settings of ASV therapy is warranted. CASE PRESENTATION: We present the case of a 42-year-old male with HF, which was caused by dilated cardiomyopathy, who was admitted to our institution for evaluating his eligibility for heart transplantation...
January 5, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28053559/systemic-lupus-erythematosus-and-pulmonary-arterial-hypertension-links-risks-and-management-strategies
#7
REVIEW
Konstantinos Tselios, Dafna D Gladman, Murray B Urowitz
Systemic lupus erythematosus (SLE) is characterized by the second highest prevalence of pulmonary arterial hypertension (PAH), after systemic sclerosis, among the connective tissue diseases. SLE-associated PAH is hemodynamically defined by increased mean pulmonary artery pressure at rest (≥25 mmHg) with normal pulmonary capillary wedge pressure (≤15 mmHg) and increased pulmonary vascular resistance. Estimated prevalence ranges from 0.5% to 17.5% depending on the diagnostic method used and the threshold of right ventricular systolic pressure in studies using transthoracic echocardiogram...
2017: Open Access Rheumatology: Research and Reviews
https://www.readbyqxmd.com/read/28050324/prevalence-of-split-nerve-fiber-layer-bundles-in-healthy-people-imaged-with-spectral-domain-optical-coherence-tomography
#8
Sirel Gür Güngör, Ahmet Akman, Almila Sarıgül Sezenöz, Gülşah Tanrıaşıkı
OBJECTIVES: The presence of retinal nerve fiber layer (RNFL) split bundles was recently described in normal eyes scanned using scanning laser polarimetry and by histologic studies. Split bundles may resemble RNFL loss in healthy eyes. The aim of our study was to determine the prevalence of nerve fiber layer split bundles in healthy people. MATERIALS AND METHODS: We imaged 718 eyes of 359 healthy persons with the spectral domain optical coherence tomography in this cross-sectional study...
December 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28039229/the-role-of-diastolic-stress-testing-in-the-evaluation-for-hfpef-a-simultaneous-invasive-echocardiographic-study
#9
Masaru Obokata, Garvan C Kane, Yogesh N V Reddy, Thomas P Olson, Vojtech Melenovsky, Barry A Borlaug
BACKGROUND: -Diagnosis of heart failure (HF) with preserved ejection fraction (HFpEF) is challenging and relies largely on demonstration of elevated cardiac filling pressures (pulmonary capillary wedge pressure, PCWP). Current guidelines recommend use of natriuretic peptides (NT-proBNP) and rest/exercise echocardiography (E/e' ratio) to make this determination. Data to support this practice is conflicting. METHODS: -Simultaneous echocardiographic-catheterization studies were prospectively conducted at rest and during exercise in subjects with invasively-proven HFpEF (n=50) and participants with dyspnea but no identifiable cardiac pathology (n=24)...
December 30, 2016: Circulation
https://www.readbyqxmd.com/read/28033056/effects-of-lateral-and-medial-wedged-insoles-on-knee-and-ankle-internal-joint-moments-during-walking-in-healthy-men
#10
Claudiane A Fukuchi, Ryan T Lewinson, Jay T Worobets, Darren J Stefanyshyn
BACKGROUND: Wedged insoles have been used to treat knee pathologies and to prevent injuries. Although they have received much attention for the study of knee injury, the effects of wedges on ankle joint biomechanics are not well understood. This study sought to evaluate the immediate effects of lateral and medial wedges on knee and ankle internal joint loading and center of pressure (CoP) in men during walking. METHODS: Twenty-one healthy men walked at 1.4 m/sec in five footwear conditions: neutral, 6° (LW6) and 9° (LW9) lateral wedges, and 6° (MW6) and 9° (MW9) medial wedges...
November 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28026030/evaluation-of-left-ventricular-diastolic-function-profile-in-patients-with-pulmonary-hypertension-due-to-heart-failure-with-preserved-ejection-fraction
#11
Pejman Raeisi-Giglou, Louis Lam, Balaji K Tamarappoo, Jennie Newman, Raed A Dweik, Adriano R Tonelli
BACKGROUND: Echocardiography plays an important role in the diagnostic work up of heart failure with preserved ejection fraction (HFpEF). We sought to determine the left ventricular (LV) diastolic profile by echocardiography in patients diagnosed with pulmonary hypertension (PH) due to PH-HFpEF. HYPOTHESIS: The study of LV diastolic function by echocardiography has limitations in patients with HFpEF and PH, and certain LV diastolic determinations convey a worse prognosis...
December 27, 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/28017355/atrial-fibrillation-in-heart-failure-with-preserved-ejection-fraction-association-with-exercise-capacity-left-ventricular-filling-pressures-natriuretic-peptides-and-left-atrial-volume
#12
Carolyn S P Lam, Michiel Rienstra, Wan Ting Tay, Licette C Y Liu, Yoran M Hummel, Peter van der Meer, Rudolf A de Boer, Isabelle C Van Gelder, Dirk J van Veldhuisen, Adriaan A Voors, Elke S Hoendermis
OBJECTIVES: This study sought to study the association of atrial fibrillation (AF) with exercise capacity, left ventricular filling pressure, natriuretic peptides, and left atrial size in heart failure with preserved ejection fraction (HFpEF). BACKGROUND: The diagnosis of heart failure with preserved ejection fraction (HFpEF) in patients with AF remains a challenge because both contribute to impaired exercise capacity, and increased natriuretic peptides and left atrial volume...
November 30, 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/28017352/the-influence-of-age-on-hemodynamic-parameters-during-rest-and-exercise-in%C3%A2-healthy-individuals
#13
Emil Wolsk, Rine Bakkestrøm, Jacob H Thomsen, Louise Balling, Mads J Andersen, Jordi S Dahl, Christian Hassager, Jakob E Møller, Finn Gustafsson
OBJECTIVES: The authors sought to obtain hemodynamic estimates across a wide age span and in both sexes for future reference and compare these estimates with current guideline diagnostic hemodynamic thresholds for abnormal filling pressure and pulmonary hypertension. BACKGROUND: At present, the influence of age on hemodynamic function is largely unknown. Because many diseases with proposed cardiac impact are more prevalent in the older population, it is pivotal to know how hemodynamic parameters are affected by age itself to discern the influence of disease from that of physiological aging...
November 30, 2016: JACC. Heart Failure
https://www.readbyqxmd.com/read/28009778/left-atrium-maximal-axial-cross-sectional-area-is-a-specific-computed-tomographic-imaging-biomarker-of-world-health-organization-group-2-pulmonary-hypertension
#14
Khalil Jivraj, Arash Bedayat, Yon K Sung, Roham T Zamanian, Francois Haddad, Ann N C Leung, Jarrett Rosenberg, H Henry Guo
PURPOSE: Left heart disease is associated with left atrial enlargement and is a common cause of pulmonary hypertension (PH). We investigated the relationship between left atrium maximal axial cross-sectional area (LA-MACSA), as measured on chest computed tomography (CT), and PH due to left heart disease (World Health Organization group 2) in patients with right heart catheterization-proven PH. MATERIALS AND METHODS: A total of 165 patients with PH who had undergone right heart catheterization with pulmonary artery pressure and pulmonary capillary wedge pressure (PCWP) measurements and nongated chest CTs were included...
December 22, 2016: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/27995825/treatment-initiation-in-paediatric-pulmonary-hypertension-insights-from-a-multinational-registry
#15
Tilman Humpl, Rolf M F Berger, Eric D Austin, Margrit S Fasnacht Boillat, Damien Bonnet, Dunbar D Ivy, Malgorzata Zuk, Maurice Beghetti, Ingram Schulze-Neick
Different treatment options for pulmonary hypertension have emerged in recent years, and evidence-based management strategies have improved quality of life and survival in adults. In children with pulmonary vascular disease, therapeutic algorithms are not so clearly defined; this study determined current treatment initiation in children with pulmonary hypertension in participating centres of a registry. Through the multinational Tracking Outcomes and Practice in Pediatric Pulmonary Hypertension registry, patient demographics, diagnosis, and treatment as judged and executed by the local physician were collected...
December 20, 2016: Cardiology in the Young
https://www.readbyqxmd.com/read/27989347/effect-of-combined-fibular-osteotomy-on-the-pressure-of-the-tibiotalar-and-talofibular-joints-in-supramalleolar-osteotomy-of-the-ankle-a%C3%A2-cadaveric-study
#16
Gi Won Choi, Soon Hyuck Lee, Kyung Wook Nha, Sung Jae Lee, Won Hyeon Kim, Chang-Sub Uhm
We investigated the effect of combined fibular osteotomy on the pressure of the tibiotalar and talofibular joints in medial opening-wedge supramalleolar osteotomy. Three different tibial osteotomy gaps (6, 8, and 10 mm) were created in 10 cadaveric models, and the pressure in the tibiotalar and talofibular joints was measured under axial load before and after fibular osteotomy. The heel alignment angle and talar translation ratio were evaluated radiographically. An increase in osteotomy gap led to increases in hindfoot valgus (p = ...
January 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/27989060/acute-invasive-hemodynamic-effects-of-transcatheter-aortic-valve-replacement
#17
Michael Chrissoheris, Antonis Ziakas, Antonis Chalapas, Stavros Chadjimiltiades, Ioannis Styliades, Charalambos Karvounis, Ioulia Nikolaou, Konstantinos Spargias
BACKGROUND: Aortic stenosis imposes a chronic pressure overload on the left ventricle, with attendant adaptations in hemodynamics, muscle mass and performance. The hemodynamic changes that occur during the initial 24 h following abrupt removal of the impediment to left ventricular outflow have not been previously examined. METHODS: A total of 52 patients with right heart catheterization was evaluated before, within 6 h and at 24 h after successful transcatheter aortic valve replacement (TAVR)...
March 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27969910/tct-543-calculation-of-serial-index-of-microvascular-resistance-with-adjusted-wedge-pressure-in-patients-with-non-st-elevation-acute-coronary-syndrome
#18
Kevin Liou, Nigel Jepson, Virag Kushwaha, Jenny Yu, Sze-Yuan Ooi
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27967108/hydraulic-droplet-coarsening-in-open-channel-capillaries
#19
Patrick B Warren
Over a range of liquid-solid contact angles, an open-channel capillary with curved or angled sides can show a maximum in the Laplace pressure as a function of the filling state. Examples include double-angle wedges, grooves scored into flat surfaces, steps on surfaces, and the groove between touching parallel cylinders. The liquid in such a channel exhibits a beading instability if the channel is filled beyond the Laplace pressure maximum. The subsequent droplet coarsening takes place by hydraulic transport through the connecting liquid columns that remain in the groove...
November 2016: Physical Review. E
https://www.readbyqxmd.com/read/27942634/the-effect-of-gme-topology-on-multicomponent-adsorption-in-zeolitic-imidazolate-frameworks
#20
Anastasios Gotzias
We employ a simulation approach to study the adsorption of single, binary and ternary mixtures on eight gme Zeolitic Imidazolate Frameworks (ZIFs) at 298 K. Four adsorbate fluids were considered; carbon dioxide, methane, nitrogen and water. We compute the high pressure adsorption density profiles inside the micropore channels of each crystal. The profiles are compared directly for the different structures and adsorbate components and used to highlight the influence of the imidazolate ligands on pure and competitive adsorption...
December 21, 2016: Physical Chemistry Chemical Physics: PCCP
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