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https://www.readbyqxmd.com/read/29456690/protective-effects-of-recombinant-human-brain-natriuretic-peptide-in-perioperative-period-during-open-heart-surgery
#1
Yunbin Xu, Yong Li, Weiguo Bao, Shi Qiu
The aim of the present study was to evaluate the protective effects and safety aspects of recombinant human brain natriuretic peptide (rhBNP) on cardiac functions of patients undergoing open-heart surgery during perioperative period. In total, 150 patients undergoing open heart surgery in the Second Hospital of Shandong Universty from August 2015 to July 2016 were randomly divided into control group and observation group each with 75 cases. Patients in control group were treated by routine rehabilitation while patients in the observation group were treated by both the routine rehabilitation and rhBNP...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29455527/mechanical-division-of-cell-sized-liposomes
#2
Siddharth Deshpande, Willem Kasper Spoelstra, Marleen van Doorn, Jacob Kerssemakers, Cees Dekker
Liposomes, self-assembled vesicles with a lipid-bilayer boundary similar to cell membranes, are extensively used in both fundamental and applied sciences. Manipulation of their physical properties, such as growth and division, may significantly expand their use as model systems in cellular and synthetic biology. Several approaches have been explored to controllably divide liposomes, such as shape transformation through temperature cycling, incorporation of additional lipids, and the encapsulation of protein division machinery...
February 18, 2018: ACS Nano
https://www.readbyqxmd.com/read/29449412/hemodynamic-characteristics-in-significant-symptomatic-and-asymptomatic-primary-mitral-valve-regurgitation-at-rest-and-during-exercise
#3
Rine Bakkestrøm, Ann Banke, Nicolaj L Christensen, Redi Pecini, Akhmadjon Irmukhamedov, Mads Andersen, Barry A Borlaug, Jacob E Møller
BACKGROUND: In severe asymptomatic primary mitral valve regurgitation without risk factors, surgery strategy is controversial. We sought to clarify whether being symptomatic corresponds to the hemodynamic burden and reduced exercise capacity. A better understanding of this may contribute to optimize timing of surgery. METHODS AND RESULTS: Subjects with asymptomatic (New York Heart Association functional class I, n=29) or symptomatic (New York Heart Association functional class II and III, n=28) significant primary mitral valve regurgitation (effective regurgitant orifice, ≥0...
February 2018: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29447180/experimental-research-on-the-structural-instability-mechanism-and-the-effect-of-multi-echelon-support-of-deep-roadways-in-a-kilometre-deep-well
#4
Rui Peng, Xiangrui Meng, Guangming Zhao, Yingming Li, Jianming Zhu
We study the structural instability mechanism and effect of a multi-echelon support in very-deep roadways. We conduct a scale model test for analysing the structural failure mechanism and the effect of multi-echelon support of roadways under high horizontal stress. Mechanical bearing structures are classified according to their secondary stress distribution and the strength degradation of the surrounding rock after roadway excavation. A new method is proposed by partitioning the mechanical bearing structure of the surrounding rock into weak, key and main coupling bearing stratums...
2018: PloS One
https://www.readbyqxmd.com/read/29413366/relative-impairments-in-hemodynamic-exercise-reserve-parameters-in-heart-failure-with-preserved-ejection%C3%A2-fraction-a-study-level-pooled-analysis
#5
Ambarish Pandey, Rohan Khera, Bryan Park, Mark Haykowsky, Barry A Borlaug, Gregory D Lewis, Dalane W Kitzman, Javed Butler, Jarett D Berry
OBJECTIVES: The aim of this study was to compare the relative impairment in different exercise hemodynamic reserve parameters in patients with heart failure with preserved ejection fraction (HFpEF) and control patients using a study-level meta-analysis. BACKGROUND: A cardinal manifestation of chronic HFpEF is severely decreased exercise capacity. Developing effective therapies for exercise intolerance in HFpEF requires optimal understanding of the factors underlying exercise intolerance...
February 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29392641/optical-coherence-tomography-angiography-findings-of-an-optic-disc-melanocytoma-in-a-glaucoma-eye
#6
Yoshiyuki Kita, Gábor Hollό, Akiko Murai, Ritsuko Kita, Akito Hirakata
PURPOSE: To determine the optical coherence tomography angiography (OCTA) characteristics of a case of optic disc melanocytoma (ODM) associated with glaucomatous visual field and retinal nerve fiber layer (RNFL) defects in normal tension glaucoma. METHODS: The left eye of a 37-year-old female patient followed for a stable ODM for 10 years was investigated with OCT, OCTA, fluorescein (FA), and indocyanine green (ICGA) angiography. The ODM was unchanged, but a previously unknown inferotemporal neuroretinal rim loss and inferotemporal and superotemporal wedge shape glaucomatous RNFL thinning were seen with corresponding glaucomatous visual field defects...
February 1, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29382891/pre-revascularization-coronary-wedge-pressure-as-marker-of-adverse-long-term-left-ventricular-remodelling-in-patients-with-acute-st-segment-elevation-myocardial-infarction
#7
Mãdãlin Constantin Marc, Adrian Corneliu Iancu, Camelia Diana Ober, Cãlin Homorodean, Şerban Bãlãnescu, Adela Viviana Sitar, Sorana Bolboacã, Ioana Mihaela Dregoesc
The aim of this study was to investigate the relationship between coronary wedge pressure (CWP), measured as a marker of pre-procedural microvascular obstruction, and left ventricular remodelling in high-risk ST-segment elevation myocardial infarction (STEMI) patients. Pre-revascularization CWP was measured in 25 patients with high-risk anterior STEMI. Left ventricular volumes and ejection fraction were echocardiographically measured at discharge and at follow-up. A 20% increase in left ventricular volumes was used to define remodelling...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29382472/exercise-induced-pulmonary-hypertension-translating-pathophysiological-concepts-into-clinical-practice
#8
Robert Naeije, Rajeev Saggar, David Badesch, Sanjay Rajagopalan, Luna Gargani, Franz Rischard, Francesco Ferrara, Alberto M Marra, Michele D'Alto, Todd M Bull, Rajan Saggar, Ekkehard Grünig, Eduardo Bossone
Exercise stress testing of the pulmonary circulation for the diagnosis of latent or early stage pulmonary hypertension is gaining acceptance. There is emerging consensus to define exercise-induced pulmonary hypertension by a mean pulmonary artery pressure higher than 30 mmHg at a cardiac output of less than 10 L/min and a total pulmonary vascular resistance higher than 3 Wood units at maximum exercise, in the absence of pulmonary hypertension at rest. Exercise-induced pulmonary hypertension has been reported in association with a bone morphogenetic receptor-2 gene mutation, in systemic sclerosis, in left heart conditions, in chronic lung diseases and in chronic pulmonary thrombo-embolism...
January 27, 2018: Chest
https://www.readbyqxmd.com/read/29380255/the-teramoto-distal-tibial-oblique-osteotomy-dtoo-surgical-technique-and-applicability-for-ankle-osteoarthritis-with-varus-deformity
#9
Tsukasa Teramoto, Shota Harada, Motoyuki Takaki, Tomohiko Asahara, Narutaka Kato, Nobuyuki Takenaka, Takasi Matsushita, Yosiaki Makino, Kouitiro Tasiro, Ootuka Kazutaka, Yukinobu Nishi, Kiyoto Kinugsa
We have devised a medial peri-articular osteotomy, the distal tibial oblique osteotomy (DTOO), and have used this technique since 1994 for ankle osteoarthritis of advanced and late stages associated with varus inclination. This report describes the surgical technique and its applicability. DTOO can be used for cases of varus ankle osteoarthritis with a range of the ankle joint movement of at least 10° or more. The osteotomy is obliquely directed cut across the distal tibia from proximal-medial to distal lateral and is of an opening-wedge type with the centre of rotation coincident with the centre of the tibiofibular joint...
January 29, 2018: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/29368799/the-influence-of-pulmonary-vascular-pressures-on-lung-diffusing-capacity-during-incremental-exercise-in-healthy-aging
#10
Kirsten E Coffman, Timothy B Curry, Niki M Dietz, Steven C Chase, Alex R Carlson, Briana L Ziegler, Bruce D Johnson
Alveolar-capillary surface area for pulmonary gas exchange falls with aging, causing a reduction in lung diffusing capacity for carbon monoxide (DLCO). However, during exercise additional factors may influence DLCO, including pulmonary blood flow and pulmonary vascular pressures. First, we sought to determine the age-dependent effect of incremental exercise on pulmonary vascular pressures and DLCO. We also aimed to investigate the dependence of DLCO on pulmonary vascular pressures during exercise via sildenafil administration to reduce pulmonary smooth muscle tone...
January 2018: Physiological Reports
https://www.readbyqxmd.com/read/29357312/pressure-algometry-is-an-excellent-tool-to-measure-knee-pain-relief-after-a-clossing-wedge-high-tibial-osteotomy
#11
R Torres-Claramunt, X Pelfort, P Hinarejos, S Gil-González, J Leal, J F Sánchez-Soler, J C Monllau
PURPOSE: The aim of this study was to assess the utility of pressure algometry (PA) to measure pain relief in the medial part of the knee after a closing-wedge high tibial osteotomy (CWHTO). METHODS: Prospective study including 44 CWHTO. Pain relief was evaluated with the visual analogue scale (VAS) and PA, a radiological study was done and a functional assessment was carried out with the KSS pre-operatively, at 6-months and at 1-year after the surgery. PA was applied to the medial and lateral part of the knee and to the infra-clavicular fossa as a control point...
January 18, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29344963/refractory-pulmonary-edema-and-upper-body-hypoxemia-during-veno-arterial-extracorporeal-membrane-oxygenation-a-case-for-atrial-septostomy
#12
Amit Prasad, Ali Ghodsizad, Christoph Brehm, Mark Kozak, Michael Körner, Aly El Banayosy, Kai Singbartl
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) provides mechanical circulatory support for patients with advanced cardiogenic shock, facilitating myocardial recovery and limiting multi-organ failure. In patients with severely limited left ventricular ejection, peripheral VA-ECMO can further increase left ventricular and left atrial pressures (LAP). Failure to decompress the left heart under these circumstances can result in pulmonary edema and upper body hypoxemia, that is, myocardial and cerebral ischemia...
January 18, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29343914/symptomatic-lower-urinary-tract-dysfunction-in-sacral-agenesis-potentially-high-risk
#13
Sanjay Sinha, Mehul A Shah, Dilip M Babu
Introduction: Sacral agenesis (SA) is a caudal regression anomaly that can cause neurogenic bladder but is not generally recognized as high risk. We studied the clinical presentation, upper urinary tract, bone and spine abnormalities, and urodynamic findings in patients with SA and compared them with related high-risk conditions, anorectal malformation (ARM), and cloacal malformation. Materials and Methods: Patient records between May 2011 and December 2015 were identified and grouped into isolated SA without an overt anomaly (Group I), SA with overt caudal regression anomalies (Group II), and ARM or cloacal malformation without the SA (Group III)...
January 2018: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29338918/filling-pressures-in-fontan-revisited-comparison-between-pulmonary-artery-wedge-ventricular-end-diastolic-and-left-atrial-pressures-in-adults
#14
William R Miranda, Alexander C Egbe, Donald J Hagler, Nathaniel W Taggart, Rick A Nishimura, Heidi M Connolly, Carole A Warnes
BACKGROUND: Pulmonary artery wedge pressure (PAWP) has been shown to correlate better with left atrial pressure (LAP) than ventricular end-diastolic pressure (VEDP) in acquired heart disease. The correlation between VEDP and PAWP and their performance as surrogates for LAP in Fontan patients is unknown. METHODS: Offline single-beat simultaneous measurement of PAWP and VEDP was performed in 50 adult Fontan patients and non-simultaneous hemodynamic data abstracted for calculation of pulmonary vascular resistance (PVR)...
December 28, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29335384/predictors-of-hemodynamic-improvement-and-stabilization-following-intraaortic-balloon-pump-implantation-in-patients-with-advanced-heart-failure
#15
Teruhiko Imamura, Colleen Juricek, Ann Nguyen, Ben Chung, Daniel Rodgers, Gabriel Sayer, Nitasha Sarswat, Gene Kim, Jayant Raikhelkar, Takeyoshi Ota, Tae Song, David Onsanger, Daniel Burkhoff, Valluvan Jeevanandam, Nir Uriel
OBJECTIVES: The intraaortic balloon pump (IABP) is currently an essential tool to improve hemodynamics in patients with advanced heart failure (HF). This study investigated predictors for hemodynamic improvement or stabilization with IABP therapy in patients with advanced HF. METHODS: Patients with advanced HF and hemodynamic deterioration treated with IABP were enrolled in this retrospective study. Invasive hemodynamics were measured before IABP implantation and 2 weeks after IABP initiation...
January 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29329993/pulmonary-arterial-hypertension-in-four-patients-treated-by-leflunomide
#16
Valentin Coirier, Alain Lescoat, Céline Chabanne, Maxime Fournet, Guillaume Coiffier, Stéphane Jouneau, Elisabeth Polard, Patrick Jégo
Pulmonary arterial hypertension (PAH) is a rare disorder that can be drug-induced, mostly following treatment by appetite-suppressant drugs. We report four cases of patients who developed PAH following a treatment by leflunomide for rheumatoid arthritis, psoriatic arthritis or undetermined connective tissue disease. All patients described a progressive dyspnea from grade II to IV of NYHA classification; clinical examination found signs of heart failure. PAH was finally diagnosed and confirmed by right heart catheterisation...
January 9, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29319942/medical-devices-obstetrical-and-gynecological-devices-classification-of-the-pressure-wedge-for-the-reduction-of-cesarean-delivery-final-order
#17
(no author information available yet)
The Food and Drug Administration (FDA or we) is classifying the pressure wedge for the reduction of cesarean delivery into class II (special controls). The special controls that apply to the device type are identified in this order and will be part of the codified language for the pressure wedge for the reduction of cesarean delivery's classification. We are taking this action because we have determined that classifying the device into class II (special controls) will provide a reasonable assurance of safety and effectiveness of the device...
December 27, 2017: Federal Register
https://www.readbyqxmd.com/read/29317729/zircon-evidence-for-incorporation-of-terrigenous-sediments-into-the-magma-source-of-continental-basalts
#18
Zheng Xu, Yong-Fei Zheng, Zi-Fu Zhao
Crustal components may be incorporated into continental basalts by either shallow contamination or deep mixing. While the former proceeds at crustal depths with common preservation of refractory minerals, the latter occurs at mantle depths with rare survival of relict minerals. Discrimination between the two mechanisms has great bearing to subcontinental mantle geochemistry. Here we report the occurrence of relict zircons in Cenozoic continental basalts from eastern China. A combined study of zircon U-Pb ages and geochemistry indicates that detrital zircons were carried by terrigenous sediments into a subcontinental subduction zone, where the zircon were transferred by fluids into the magma sources of continental basalts...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29317120/preoperative-invasive-hemodynamic-determinants-of-survival-among-patients-undergoing-aortic-or-mitral-valve-surgery
#19
David X Zhuo, Kenneth C Bilchick, Sula Mazimba
OBJECTIVES: To evaluate the association of preoperative invasive hemodynamic parameters with mortality in valvular heart surgery. DESIGN: Retrospective cohort study. SETTING: Single tertiary academic medical center. PARTICIPANTS: A total of 382 patients who underwent preoperative right and/or left heart catheterization before open aortic valve replacement (AVR), open mitral valve repair/replacement (MVR), or combined AVR and MVR, from July 2009 to December 2014...
September 29, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29316567/modern-invasive-hemodynamic-assessment-of-pulmonary-hypertension
#20
Alberto Pagnamenta, Frédéric Lador, Andrea Azzola, Maurice Beghetti
Since 1998 pulmonary hypertension has been clinically classified into five well-defined, distinct categories. A definitive diagnosis of pulmonary hypertension requires the invasive confirmation of an elevated mean pulmonary artery pressure of 25 mm Hg or above during a right heart catheterization. From a hemodynamic point of view, pulmonary hypertension is classified into precapillary and postcapillary pulmonary hypertension on the basis of a pulmonary artery wedge pressure threshold value of 15 mm Hg. Pulmonary vascular resistance is better characterized by multi-point pressure/flow measurements than by single-point determination...
January 9, 2018: Respiration; International Review of Thoracic Diseases
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