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https://www.readbyqxmd.com/read/28649190/effects-of-light-and-sound-on-the-prefrontal-cortex-activation-and-emotional-function-a-functional-near-infrared-spectroscopy-study
#1
Shota Hori, Koichi Mori, Takehisa Mashimo, Akitoshi Seiyama
We constructed a near infrared spectroscopy-based real-time feedback system to estimate the subjects' emotional states using the changes in oxygenated hemoglobin concentration [Δ(oxy-Hb)] in the prefrontal cortex (PFC). Using this system, we investigated the influences of continual mild and equivocal stimuli consisting of lights and a reconstructed waterfall sound on Δ[oxy-Hb] in the PFC. The visual (light) and auditory (sound) stimuli changed randomly and independently, depending on the emotional states of the individual subjects...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28497023/the-waterfall-effect-in-breast-augmentation
#2
REVIEW
James Frame
The 'waterfall effect' is a descriptive term to indicate a sliding ptosis of parenchymal breast tissue over a fixed or encapsulated implant. It occurs more frequently than surgeons anticipate and especially over the longer term after augmentation. Certain breast implants are more prone to contribute to this problem as are implants placed in submuscular pockets that ride high, especially in women with anatomical musculoskeletal variance or asymmetry. This article describes the aetiology of sliding ptosis in more detail, the relevant anatomy and the surgical correction...
April 2017: Gland Surgery
https://www.readbyqxmd.com/read/28426005/antarctic-ice-shelf-potentially-stabilized-by-export-of-meltwater-in-surface-river
#3
Robin E Bell, Winnie Chu, Jonathan Kingslake, Indrani Das, Marco Tedesco, Kirsty J Tinto, Christopher J Zappa, Massimo Frezzotti, Alexandra Boghosian, Won Sang Lee
Meltwater stored in ponds and crevasses can weaken and fracture ice shelves, triggering their rapid disintegration. This ice-shelf collapse results in an increased flux of ice from adjacent glaciers and ice streams, thereby raising sea level globally. However, surface rivers forming on ice shelves could potentially export stored meltwater and prevent its destructive effects. Here we present evidence for persistent active drainage networks-interconnected streams, ponds and rivers-on the Nansen Ice Shelf in Antarctica that export a large fraction of the ice shelf's meltwater into the ocean...
April 19, 2017: Nature
https://www.readbyqxmd.com/read/28268885/an-object-oriented-model-of-the-cardiopulmonary-system-with-emphasis-on-the-gravity-effect
#4
Chuong Ngo, Silvia Briones Herranz, Berno Misgeld, Thomas Vollmer, Steffen Leonhardt
We introduce a novel comprehensive model of the cardiopulmonary system with emphasis on perfusion and ventilation distribution along the vertical thorax axis under the gravity effect. By using an object-oriented environment, the complex physiological system can be represented by a network of electrical, lumped-element compartments. The lungs are divided into three zones: upper, middle, and lower zone. Blood flow increases with the distance from the apex to the base of the lungs. The upper zone is characterized by a complete collapse of the pulmonary capillary vasculature; thus, there is no flow in this zone...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227085/an-object-oriented-model-of-the-cardiopulmonary-system-with-emphasis-on-the-gravity-effect
#5
Chuong Ngo, Silvia Briones Herranz, Berno Misgeld, Thomas Vollmer, Steffen Leonhardt, Chuong Ngo, Silvia Briones Herranz, Berno Misgeld, Thomas Vollmer, Steffen Leonhardt, Thomas Vollmer, Steffen Leonhardt, Chuong Ngo, Berno Misgeld
We introduce a novel comprehensive model of the cardiopulmonary system with emphasis on perfusion and ventilation distribution along the vertical thorax axis under the gravity effect. By using an object-oriented environment, the complex physiological system can be represented by a network of electrical, lumped-element compartments. The lungs are divided into three zones: upper, middle, and lower zone. Blood flow increases with the distance from the apex to the base of the lungs. The upper zone is characterized by a complete collapse of the pulmonary capillary vasculature; thus, there is no flow in this zone...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28086991/does-waterfall-aerosol-influence-mucosal-immunity-and-chronic-stress-a-randomized-controlled-clinical-trial
#6
RANDOMIZED CONTROLLED TRIAL
Carina Grafetstätter, Martin Gaisberger, Johanna Prossegger, Markus Ritter, Predrag Kolarž, Christina Pichler, Josef Thalhamer, Arnulf Hartl
BACKGROUND: The specific microclimate of alpine waterfalls with high levels of ionized water aerosols has been suggested to trigger beneficial immunological and psychological effects. In the present three-armed randomized controlled clinical study, we focused on effects on (i) immunological reagibility, on (ii) physiological stress responses, and on (iii) stress-related psychological parameters. METHODS: People with moderate to high stress levels (n = 65) spent an active sojourn with daily hiking tours in the National Park Hohe Tauern (Großkirchheim, Austria)...
January 13, 2017: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/28040485/ecological-characteristics-of-simulium-breeding-sites-in-west-africa
#7
Robert A Cheke, Stephen Young, Rolf Garms
Twenty-nine taxa of Simulium were identified amongst 527 collections of larvae and pupae from untreated rivers and streams in Liberia (362 collections in 1967-71 & 1989), Togo (125 in 1979-81), Benin (35 in 1979-81) and Ghana (5 in 1980-81). Presence or absence of associations between different taxa were used to group them into six clusters using Ward agglomerative hierarchical cluster analysis. Environmental data associated with the pre-imaginal habitats were then analysed in relation to the six clusters by one way ANOVA...
March 2017: Acta Tropica
https://www.readbyqxmd.com/read/27933011/psychological-restoration-can-depend-on-stimulus-source-attribution-a-challenge-for-the-evolutionary-account
#8
Andreas Haga, Niklas Halin, Mattias Holmgren, Patrik Sörqvist
Visiting or viewing nature environments can have restorative psychological effects, while exposure to the built environment typically has less positive effects. A classic view is that this difference in restorative potential of nature and built environments depends on differences in the intrinsic characteristics of the stimuli. In addition, an evolutionary account is often assumed whereby restoration is believed to be a hardwired response to nature's stimulus-features. Here, we propose the novel hypothesis that the restorative effects of a stimulus do not entirely depend on the stimulus-features per se, but also on the meaning that people assign to the stimulus...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27774996/rna-sequencing-analysis-of-human-podocytes-reveals-glucocorticoid-regulated-gene-networks-targeting-non-immune-pathways
#9
Lulu Jiang, Charles C T Hindmarch, Mark Rogers, Colin Campbell, Christy Waterfall, Jane Coghill, Peter W Mathieson, Gavin I Welsh
Glucocorticoids are steroids that reduce inflammation and are used as immunosuppressive drugs for many diseases. They are also the mainstay for the treatment of minimal change nephropathy (MCN), which is characterised by an absence of inflammation. Their mechanisms of action remain elusive. Evidence suggests that immunomodulatory drugs can directly act on glomerular epithelial cells or 'podocytes', the cell type which is the main target of injury in MCN. To understand the nature of glucocorticoid effects on non-immune cell functions, we generated RNA sequencing data from human podocyte cell lines and identified the genes that are significantly regulated in dexamethasone-treated podocytes compared to vehicle-treated cells...
October 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27768533/cod-and-nitrogen-removal-and-microbial-communities-in-a-novel-waterfall-biofilm-reactor-operated-at-different-cod-tn-ratios
#10
Siyao Wang, Yuewu Pu, Cheng Wei
The aim of this study was to characterize the pollutant removal efficiency and the microbial communities that arose in a newly designed waterfall biofilm reactor (WFBR) at different chemical oxygen demand/total nitrogen (COD/TN) ratios. The reactor was operated continuously for 28 days at different COD/TN ratios, and its efficiency was evaluated. Results showed that as the thickness of the biofilm increased, the structure of the biofilm encouraged anaerobic-aerobic, anoxic-anaerobic, and fully anaerobic conditions in one reactor...
January 28, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27580928/a-practical-bayesian-design-to-identify-the-maximum-tolerated-dose-contour-for-drug-combination-trials
#11
Liangcai Zhang, Ying Yuan
Drug combination therapy has become the mainstream approach to cancer treatment. One fundamental feature that makes combination trials different from single-agent trials is the existence of the maximum tolerated dose (MTD) contour, that is, multiple MTDs. As a result, unlike single-agent phase I trials, which aim to find a single MTD, it is often of interest to find the MTD contour for combination trials. We propose a new dose-finding design, the waterfall design, to find the MTD contour for drug combination trials...
November 30, 2016: Statistics in Medicine
https://www.readbyqxmd.com/read/27527412/pathway-related-molecules-of-vegfc-d-vegfr3-nrp2-axis-in-tumor-lymphangiogenesis-and-lymphatic-metastasis
#12
REVIEW
Jingwen Wang, Yuhong Huang, Jun Zhang, Yuanyi Wei, Salma Mahoud, Ahmed Musa Hago Bakheet, Li Wang, Shuting Zhou, Jianwu Tang
Precondition for tumor lymphatic metastasis is that tumor cells induce formation of original and newborn lymphatic vessels and invade surrounding lymphatic vessels in tumor stroma, while some pathway-related molecules play an important role in mechanisms associated with proliferation and migration of lymphatic endothelial cells (LECs) and tumor cells. In lymphangiogenesis and lymphatic metastasis, the pathway-related molecules of VEGFC/D-VEGFR3/NRP2 axis, such as Furin-like enzyme, CNTN1, Prox1, LYVE-1, Podoplanin, SOX18, SDF1 and CXCR4, are direct constitutors as a portion of VEGFC/D-VEGFR3/NRP2 axis, and their biological activities rely on this ligand-receptor system...
October 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27422991/effect-of-peep-blood-volume-and-inspiratory-hold-maneuvers-on-venous-return
#13
David Berger, Per W Moller, Alberto Weber, Andreas Bloch, Stefan Bloechlinger, Matthias Haenggi, Soren Sondergaard, Stephan M Jakob, Sheldon Magder, Jukka Takala
According to Guyton's model of circulation, mean systemic filling pressure (MSFP), right atrial pressure (RAP), and resistance to venous return (RVR) determine venous return. MSFP has been estimated from inspiratory hold-induced changes in RAP and blood flow. We studied the effect of positive end-expiratory pressure (PEEP) and blood volume on venous return and MSFP in pigs. MSFP was measured by balloon occlusion of the right atrium (MSFPRAO), and the MSFP obtained via extrapolation of pressure-flow relationships with airway occlusion (MSFPinsp_hold) was extrapolated from RAP/pulmonary artery flow (QPA) relationships during inspiratory holds at PEEP 5 and 10 cmH2O, after bleeding, and in hypervolemia...
September 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27342803/cerealsdb-3-0-expansion-of-resources-and-data-integration
#14
Paul A Wilkinson, Mark O Winfield, Gary L A Barker, Simon Tyrrell, Xingdong Bian, Alexandra M Allen, Amanda Burridge, Jane A Coghill, Christy Waterfall, Mario Caccamo, Robert P Davey, Keith J Edwards
BACKGROUND: The increase in human populations around the world has put pressure on resources, and as a consequence food security has become an important challenge for the 21st century. Wheat (Triticum aestivum) is one of the most important crops in human and livestock diets, and the development of wheat varieties that produce higher yields, combined with increased resistance to pests and resilience to changes in climate, has meant that wheat breeding has become an important focus of scientific research...
June 24, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27191467/effects-of-a-small-natural-barrier-on-the-spatial-distribution-of-the-fish-assemblage-in-the-verde-river-upper-paran%C3%A3-river-basin-brazil
#15
J C Silva, É A Gubiani, P A Piana, R L Delariva
Geographical barriers influence species distribution and play an important role in the segregation of fish assemblages. The present study aims to test the influence of a small natural barrier on the spatial distribution of fish species in the Verde River, Upper Paraná River Basin, Brazil, considering two biotopes: upstream and downstream of the Branca Waterfall. We observed the highest species richness downstream of the Branca Waterfall, which also had the highest number of exclusive species. Richness, evenness, and abundance varied significantly among biotopes...
October 2016: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/27161500/variance-after-effects-distort-risk-perception-in-humans
#16
Elise Payzan-LeNestour, Bernard W Balleine, Tony Berrada, Joel Pearson
In many contexts, decision-making requires an accurate representation of outcome variance-otherwise known as "risk" in economics. Conventional economic theory assumes this representation to be perfect, thereby focusing on risk preferences rather than risk perception per se [1-3] (but see [4]). However, humans often misrepresent their physical environment. Perhaps the most striking of such misrepresentations are the many well-known sensory after-effects, which most commonly involve visual properties, such as color, contrast, size, and motion...
June 6, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/26962861/whole-genome-sequencing-of-newly-established-pancreatic-cancer-lines-identifies-novel-somatic-mutation-c-2587g-a-in-axon-guidance-receptor-plexin-a1-as-enhancer-of-proliferation-and-invasion
#17
Rebecca Sorber, Yaroslav Teper, Abisola Abisoye-Ogunniyan, Joshua J Waterfall, Sean Davis, J Keith Killian, Marbin Pineda, Satyajit Ray, Matt R McCord, Holger Pflicke, Sandra Sczerba Burkett, Paul S Meltzer, Udo Rudloff
The genetic profile of human pancreatic cancers harbors considerable heterogeneity, which suggests a possible explanation for the pronounced inefficacy of single therapies in this disease. This observation has led to a belief that custom therapies based on individual tumor profiles are necessary to more effectively treat pancreatic cancer. It has recently been discovered that axon guidance genes are affected by somatic structural variants in up to 25% of human pancreatic cancers. Thus far, however, some of these mutations have only been correlated to survival probability and no function has been assigned to these observed axon guidance gene mutations in pancreatic cancer...
2016: PloS One
https://www.readbyqxmd.com/read/26842772/design-of-crystal-like-aperiodic-solids-with-selective-disorder-phonon-coupling
#18
Alistair R Overy, Andrew B Cairns, Matthew J Cliffe, Arkadiy Simonov, Matthew G Tucker, Andrew L Goodwin
Functional materials design normally focuses on structurally ordered systems because disorder is considered detrimental to many functional properties. Here we challenge this paradigm by showing that particular types of strongly correlated disorder can give rise to useful characteristics that are inaccessible to ordered states. A judicious combination of low-symmetry building unit and high-symmetry topological template leads to aperiodic 'procrystalline' solids that harbour this type of disorder. We identify key classes of procrystalline states together with their characteristic diffraction behaviour, and establish mappings onto known and target materials...
2016: Nature Communications
https://www.readbyqxmd.com/read/26827159/techniques-for-assisting-difficult-delivery-at-caesarean-section
#19
REVIEW
Heather Waterfall, Rosalie M Grivell, Jodie M Dodd
BACKGROUND: Caesarean section involves making an incision in the woman's abdomen and cutting through the uterine muscle. The baby is then delivered through that incision. Difficult caesarean birth may result in injury for the infant or complications for the mother. Methods to assist with delivery include vacuum or forceps extraction or manual delivery utilising fundal pressure. Medication that relaxes the uterus (tocolytic medication) may facilitate the birth of the baby at caesarean section...
January 31, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26790025/sympatric-apes-in-sacred-forests-shared-space-and-habitat-use-by-humans-and-endangered-javan-gibbons-hylobates-moloch
#20
Melissa Ann Reisland, Joanna E Lambert
In this research, we use a combination of ethnographic observation and GIS analysis to explore the use of space by humans and gibbons (Hylobates moloch) to determine areas of potential space competition in the sacred forest and nature reserve Cagar Alam Leuweung Sancang in West Java, Indonesia. More specifically, we test whether gibbons respond to the presence of humans in a manner consistent with predator-avoidance and predicted that the gibbon study subjects would avoid areas visited by humans (Risk-Disturbance Hypothesis)...
2016: PloS One
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