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https://www.readbyqxmd.com/read/28803744/novel-1l-polyethylene-glycol-based-bowel-preparation-ner1006-for-overall-and-right-sided-colon-cleansing-a-randomized-controlled-phase-3-trial-versus-trisulfate
#1
Michael P DeMicco, Lucy B Clayton, Jeff Pilot, Michael S Epstein
BACKGROUND AND AIMS: NER1006 is the first 32 fluid ounce (1L) polyethylene glycol-based bowel preparation. This randomized, multicenter, colonoscopist/central reader-blinded Phase 3 non-inferiority trial assessed the efficacy, safety, and tolerability of NER1006 versus trisulfate for bowel cleansing. METHODS: Patients undergoing colonoscopy were randomized (1:1) to receive NER1006 or trisulfate, using evening/morning split-dosing administration. Blinded central readers used the validated Harefield Cleansing Scale (HCS) to evaluate 2 alternative primary endpoints: overall bowel cleansing success and high-quality cleansing of the ascending colon/cecum...
August 10, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28799428/full-spectrum-endoscopy-fuse-versus-standard-forward-viewing-endoscope-sfv-in-a-high-risk-population
#2
Søren Roepstorff, Sabah Anwar Hadi, Morten Rasmussen
OBJECTIVES: To investigate the diagnostic performance of Full Spectrum Endoscopy (FUSE) compared to a conventional standard forward-viewing endoscope (SFV). The primary outcome was adenoma detection rate (ADR) and mean adenoma detection. Secondary outcome was feasibility of FUSE opposed to SFV. MATERIALS AND METHODS: Consecutive patients participating in the Danish colorectal cancer (CRC) screening programme were prospectively included in the study (n = 205)...
August 11, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28791330/computer-assisted-instruction-before-colonoscopy-is-as-effective-as-nurse-counselling-a-clinical-pilot-trial
#3
Govert Veldhuijzen, Michael Klemt-Kropp, Casper Noomen, Aura A Van Esch, Eric T Tjwa, Joost Drenth
BACKGROUND AND STUDY AIMS:  Better patient education prior to colonoscopy improves adherence to instructions for bowel preparation and leads to cleaner colons. We reasoned that computer assisted instruction (CAI) using video and 3 D animations followed by nurse contact maximizes the effectiveness of nurse counselling, increases proportion of clean colons and improves patient experience. PATIENTS AND METHODS:  Adults referred for colonoscopy in a high-volume endoscopy unit in the Netherlands were included...
August 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28791043/systematic-review-outcomes-by-duration-of-npo-status-prior-to-colonoscopy
#4
REVIEW
Aasma Shaukat, Ashish Malhotra, Nancy Greer, Roderick MacDonald, Joseph Wels, Timothy J Wilt
BACKGROUND/AIMS: Variation exists among anesthesia providers as to acceptable timing of NPO ("nothing by mouth") for elective colonoscopy procedures. There is a need to balance optimal colonic preparation, patient convenience, and scheduling efficiency with anesthesia safety concerns. We reviewed the evidence for the relationship between NPO timing and aspiration incidence and colonoscopy rescheduling. METHODS: We searched MEDLINE (1990-April 2015) for English language studies of any design and included them if at least one bowel preparation regimen was completed within 8 hours of colonoscopy...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28761869/correlation-between-bowel-preparation-and-the-adenoma-detection-rate-in-screening-colonoscopy
#5
Jung Hun Park, Sang Jin Kim, Jong Hee Hyun, Kyung Su Han, Byung Chang Kim, Chang Won Hong, Sang-Jeon Lee, Dae Kyung Sohn
PURPOSE: The adenoma detection rate is commonly used as a measure of the quality of colonoscopy. This study assessed both the association between the adenoma detection rate and the quality of bowel preparation and the risk factors associated with the adenoma detection rate in screening colonoscopy. METHODS: This retrospective analysis involved 1,079 individuals who underwent screening colonoscopy at the National Cancer Center between December 2012 and April 2014...
June 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/28759612/scheduling-rules-for-patients-with-diabetes-mellitus-that-facilitate-split-dosing-improve-the-quality-of-bowel-preparation-for-colonoscopy
#6
Robert J Hilsden, Ronald Bridges, Catherine Dube, Steven J Heitman, Alaa Rostom
BACKGROUND & AIMS: An adequate bowel preparation for colonoscopy is best achieved by giving the cleansing regimen as a split-dose with the second dose given 4-6 hours before the procedure. This can be difficult to administer to diabetics who are preferentially scheduled for early morning procedures. We examined the impact on bowel preparation quality of scheduling diabetics for mid-morning (9:30 am or later) procedures rather than early morning procedures (7:30-9:00 AM) to facilitate a split-dose preparation...
2017: PloS One
https://www.readbyqxmd.com/read/28753700/a-new-composite-measure-of-colonoscopy-the-performance-indicator-of-colonic-intubation-pici
#7
Roland M Valori, Sarah Damery, Daniel R Gavin, John T Anderson, Mark T Donnelly, J Graham Williams, Edwin T Swarbrick
Background and study aim Cecal intubation rate (CIR) is an established performance indicator of colonoscopy. In some patients, cecal intubation with acceptable tolerance is only achieved with additional sedation. This study proposes a composite Performance Indicator of Colonic Intubation (PICI), which combines CIR, comfort, and sedation. Methods Data from 20 085 colonoscopies reported in the 2011 UK national audit were analyzed. PICI was defined as the percentage of procedures achieving cecal intubation with median dose (2 mg) of midazolam or less, and nurse-assessed comfort score of 1 - 3/5...
July 28, 2017: Endoscopy
https://www.readbyqxmd.com/read/28742732/educational-colonoscopy-video-enhances-bowel-preparation-quality-and-comprehension-in-an-inner-city-population
#8
Ajish Pillai, Radha Menon, David Oustecky, Asyia Ahmad
BACKGROUND: Quality of bowel preparation and patient knowledge remains a major barrier for completing colorectal cancer screening. Few studies have tested unique ways to impact patient understanding centering on interactive computer programs, pictures, and brochures. Two studies explored instructional videos but focused on patient compliance and anxiety as endpoints. Furthermore, excessive video length and content may limit their impact on a broad patient population. No study so far has studied a video's impact on preparation quality and patient understanding of the colonoscopy procedure...
July 24, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28737648/who-is-responsible-for-what-happens-before-during-and-after-colonoscopy-results-of-a-national-survey-of-primary-care-physicians
#9
Andrew J Read, Arlene Weissman, Philip S Schoenfeld, Seema Saini, Stacy B Menees, Sameer D Saini
BACKGROUND AND AIMS: Primary care providers (PCPs) play a critical role in colon cancer screening by initiating referrals to gastroenterologists for colonoscopy, but little is known about their role in pre-colonoscopy bowel preparation selection and pre-colonoscopy follow-up care. This study aimed to better understand coordination of care between PCPs and gastroenterologists as well as the current availability of "open-access" screening colonoscopy. METHODS: A multiple-choice survey was developed to assess PCPs' experiences with open-access colonoscopy, their involvement in the pre-colonoscopy process, and follow-up after colonoscopy...
July 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28727630/same-day-versus-split-dose-bowel-preparation-before-colonoscopy-a-meta-analysis
#10
Yuan-Lung Cheng, Kuang-Wei Huang, Wei-Chih Liao, Jiing-Chyuan Luo, Keng-Hsin Lan, Chien-Wei Su, Yuan-Jen Wang, Ming-Chih Hou
BACKGROUND: Split-dose regimens (SpDs) were recommended as a first choice for bowel preparation, whereas same-day regimens (SaDs) were recommended as an alternative; however, randomized trials compared them with mixed results. The meta-analysis was aimed at clarifying efficacy level between the 2 regimens. MATERIALS AND METHODS: We used MEDLINE/PubMed, EMBASE, Scopus, CINAHL, Cochrane Library, and Web of Science to identify randomized trials published from 1990 to 2016, comparing SaDs to SpDs in adults...
July 19, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28727629/an-automated-inpatient-split-dose-bowel-preparation-system-improves-colonoscopy-quality-and-reduces-repeat-procedures
#11
Rena Yadlapati, Elyse R Johnston, Adam B Gluskin, Dyanna L Gregory, Rachel Cyrus, Lindsay Werth, Jody D Ciolino, David P Grande, Rajesh N Keswani
BACKGROUND/GOALS: Inpatient colonoscopy preparations are often inadequate, compromising patient safety and procedure quality, while resulting in greater hospital costs. The aims of this study were to: (1) design and implement an electronic inpatient split-dose bowel preparation order set; (2) assess the intervention's impact upon preparation adequacy, repeated colonoscopies, hospital days, and costs. STUDY: We conducted a single center prospective pragmatic quasiexperimental study of hospitalized adults undergoing colonoscopy...
July 19, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28723857/the-clinical-and-economic-effects-of-targeted-bowel-preparation-results-of-a-decision-analysis
#12
Jacob E Kurlander, Shahnaz Sultan, Sameer D Saini
BACKGROUND: Colonoscopy bowel preparation failure is common, costly, and clinically harmful. Prediction models can identify patients at high risk for preparation failure, but they are rarely used. GOALS: To investigate the clinical and economic effects of using a more intensive preparation upfront (a "targeted" strategy) for patients identified as high risk for preparation failure. STUDY: We developed a Markov decision analytic model to compare usual care with a targeted strategy...
July 18, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28723744/association-between-bowel-habits-and-quality-of-bowel-preparation-for-colonoscopy
#13
Dong-Won Lee, Ja Seol Koo, Seonghee Kang, Seung Young Kim, Jong Jin Hyun, Sung Woo Jung, Hyung Joon Yim, Sang Woo Lee
The effectiveness of colonoscopy is highly dependent on the quality of bowel preparation. Although many studies have previously evaluated the role of cleansing methods and dosing regimens, few have examined the association between bowel habits and subsequent bowel preparation. Here, we aimed to evaluate the impact of bowel habits on the quality of bowel preparation.A total of 404 patients who underwent a total colonoscopy and completed a personal bowel habit questionnaire at Korea University Hospital between December 2012 and December 2013 were enrolled...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28706429/comparing-reduced-dose-sodium-phosphate-tablets-to-2-l-of-polyethylene-glycol-a-randomized-study
#14
Soichiro Ako, Koji Takemoto, Eriko Yasutomi, Chihiro Sakaguchi, Mayu Murakami, Tomoko Sunami, Shohei Oka, Hamada Kenta, Noriko Okazaki, Yuki Baba, Yasushi Yamasaki, Toshiyuki Asato, Daisuke Kawai, Ryuta Takenaka, Hirohumi Tsugeno, Sakiko Hiraoka, Jun Kato, Shigeatsu Fujiki
AIM: To compare the tolerability and quality of bowel cleansing between 2 L polyethylene glycol (PEG) and reduced-dose sodium phosphate (NaP) tablets as a preparation for colonoscopy. METHODS: Two hundred patients were randomly assigned to the PEG or NaP groups at the same ratio. The NaP group patients took 30 tablets with 2 L of clear liquid, while the PEG group patients took 2L of PEG. Tolerability was assessed by a questionnaire about taste, volume, and the overall impression...
June 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28706428/appropriateness-of-the-study-of-iron-deficiency-anemia-prior-to-referral-for-small-bowel-evaluation-at-a-tertiary-center
#15
Jaime Pereira Rodrigues, Rolando Pinho, Joana Silva, Ana Ponte, Mafalda Sousa, João Carlos Silva, João Carvalho
AIM: To evaluate the adequacy of the study of iron deficiency anemia (IDA) in real life practice prior to referral to a gastroenterology department for small bowel evaluation. METHODS: All consecutive patients referred to a gastroenterology department for small bowel investigation due to iron deficiency anemia, between January 2013 and December 2015 were included. Both patients referred from general practitioners or directly from different hospital departments were selected...
June 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28684185/transabdominal-ultrasound-colonography-for-detection-of-colorectal-neoplasms-initial-clinical-experience
#16
Jin-Ya Liu, Li-Da Chen, Jian-Bo Xu, Hui Wu, Jin-Ning Ye, Xin-Hua Zhang, Xiao-Yan Xie, Wei Wang, Ming-De Lu
We investigated the feasibility of using ultrasound colonography (USC) to visualize the healthy colon and rectum and detect colorectal polyps. Eight healthy volunteers underwent USC after standard bowel preparation. The feasibility and image quality of USC in different segments were evaluated. Then, USC was conducted on eight patients with known colonic neoplasms using colonoscopy as the reference standard. For volunteers, USC examinations were successfully performed on four (50.0%) ascending, three (37.5%) transverse and eight (100%) descending colons, as well as all sigmoid colons and rectums...
July 3, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28681075/cost-analysis-of-colorectal-cancer-screening-with-ct-colonography-in-italy
#17
Paola Mantellini, Giuseppe Lippi, Lapo Sali, Grazia Grazzini, Silvia Delsanto, Beatrice Mallardi, Massimo Falchini, Guido Castiglione, Francesca Maria Carozzi, Mario Mascalchi, Stefano Milani, Leonardo Ventura, Marco Zappa
OBJECTIVE: Unit costs of screening CT colonography (CTC) can be useful for cost-effectiveness analyses and for health care decision-making. We evaluated the unit costs of CTC as a primary screening test for colorectal cancer in the setting of a randomized trial in Italy. METHODS: Data were collected within the randomized SAVE trial. Subjects were invited to screening CTC by mail and requested to have a pre-examination consultation. CTCs were performed with 64- and 128-slice CT scanners after reduced or full bowel preparation...
July 5, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28676254/patient-navigation-for-colonoscopy-completion-results-of-an-rct
#18
Amy DeGroff, Paul C Schroy, Kerry Grace Morrissey, Beth Slotman, Elizabeth A Rohan, James Bethel, Jennifer Murillo, Weijia Ren, Shelley Niwa, Steven Leadbetter, Djenaba Joseph
INTRODUCTION: Colorectal cancer is a leading cause of cancer-related death in the U.S. Although screening reduces colorectal cancer incidence and mortality, screening rates among U.S. adults remain less than optimal, especially among disadvantaged populations. This study examined the efficacy of patient navigation to increase colonoscopy screening. STUDY DESIGN: RCT. SETTING/PARTICIPANTS: A total of 843 low-income adults, primarily Hispanic and non-Hispanic blacks, aged 50-75 years referred for colonoscopy at Boston Medical Center were randomized into the intervention (n=429) or control (n=427) groups...
July 1, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28669148/the-impact-of-patient-education-with-a-smartphone-application-on-the-quality-of-bowel-preparation-for-screening-colonoscopy
#19
JeongHyeon Cho, SeungHee Lee, Jung A Shin, Jeong Ho Kim, Hong Sub Lee
Background/Aims: Few studies have evaluated the use of a smartphone application (app) for educating people undergoing colonoscopy and optimizing bowel preparation. Therefore, this study was designed to develop a smartphone app for people to use as a preparation guide and to evaluate the efficacy of this app when used prior to colonoscopy. Methods: In total, 142 patients (male:female=84:58, mean age=43.5±9.3 years), who were scheduled to undergo a colonoscopy at Myongji Hospital, were enrolled in this study...
July 3, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28649124/a-modified-bowel-preparation-regimen-for-colonoscopy-providing-the-patients-satisfaction-and-convenience
#20
Chia-Cheng Wen, Shu-Wen Jao, Cheng-Wen Hsiao
BACKGROUND A complete cleansing of the bowel is a critical factor that impacts the diagnostic accuracy of colonoscopies. However, the common bowel preparation regimen of two 45 mL doses of sodium phosphate (2×NaP) often leads to uncomfortable symptoms and subsequently lower patient adherence. To improve patient adherence and satisfaction, we proposed a modified regimen composed of two sennoside tablets and one bottle of NaP (S+NaP) and we then evaluated bowel preparation quality and patient satisfaction. MATERIAL AND METHODS A total of 531 patients who underwent colonoscopies at the outpatient coloproctology clinic from January 2016 to December 2016 were retrospectively reviewed...
June 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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