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Serap Argun Baris, Dilek Tuncel, Cigdem Ozerdem, Huseyin Kutlu, Tugba Onyilmaz, Ilknur Basyigit, Hasim Boyaci, Fusun Yildiz
BACKGROUND: The aim of this study is to evaluate the presence of neurocognitive dysfunctions, depression and anxiety and the effect of positive airway pressure (PAP) therapy on these alterations in Obesity Hypoventilation Syndrome (OHS) patients. METHODS: Ten healthy normal and obese controls, 10 OHS and 10 OSAS patients were included in the study. Short form-36, Beck Depression Scale and State-Trade Anxiety Inventory (STAI 1-2) were performed. Wisconsin Card Sorting Test (WCST), Montreal Cognitive Assessment Scale (MOCA), Enhanced Cued Recall (ECR) and Mini Mental Test (MMT) were used for neurocognitive evaluation...
2016: Multidisciplinary Respiratory Medicine
Serap Sunar, Mustafa Anar, Meryem Sengul, Guleray Agar
In this research, the genotoxic and antigenotoxic effects of methanol extract of Sempervivum armenum (MSA) were studied using micronucleus (MN) test and sister chromatid exchange (SCE) test systems in cultured human peripheral blood cells. According to the SCE and MN tests results, MSA reduced the genotoxic effects of aflatoxin B1. In order to explain the reason for the antigenotoxic effects of MSA, antioxidants levels were determined. Cotreatments of 5, 10, 20 mg/mL concentrations of MSA with aflatoxin B1 decreased the frequencies of SCE, MN and the malondialdehyde level and increased the amount of superoxide dismutase, glutathione and glutathione peroxidase which were decreased by aflatoxin...
October 18, 2016: Cytotechnology
Maryam Parsian, Pelin Mutlu, Serap Yalcin, Aysen Tezcaner, Ufuk Gunduz
Tumor-specific delivery of anticancer drugs by magnetic nanoparticles will maximize the efficacy of the drug and minimize side effects, and reduce systemic toxicity. The magnetic core of these nanoparticles provides an advantage for selective drug targeting as they can be targeted to the tumor site and accumulated in cancer cells by means of an external magnetic field. Magnetic nanoparticles can be coated with Polyamidoamine (PAMAM) dendrimer and loaded with drugs. However, biomedical applications of PAMAM dendrimers are limited due to their toxicity associated with their multiple cationic charges due to terminal NH2 groups...
October 7, 2016: International Journal of Pharmaceutics
Serap Şimşek Yavuz, Ezgi Özbek, Seniha Başaran, Bekir Çelebi, Ebru Yılmaz, Murat Başaran, Berrin Umman, Haluk Eraksoy
No abstract text is available yet for this article.
October 2016: Anatolian Journal of Cardiology
Sevgi Yavuz, Samet Kocabay, Serap Çetinkaya, Birnur Akkaya, Recep Akkaya, Ali Fazil Yenidunya, Mustafa Zahir Bakıcı
A thermostable metalloprotease, produced from an environmental strain of Candida kefyr 41 PSB, was purified 16 fold with a 60% yield by cold ethanol precipitation and affinity chromatography (bentonite-acrylamide-cysteine microcomposite). The purified enzyme appeared as a single protein band at 43kDa. Its optimum pH and temperature points were found to be 7.0 and 105°C, respectively. Km and Vmax values of the enzyme were determined to be 3.5mg/mL and 4.4μmolmL(-1)min(-1), 1.65mg/mL and 6.1μmolmL(-1)min(-1), using casein and gelatine as the substrates, respectively...
October 4, 2016: International Journal of Biological Macromolecules
Emrah Çakmakçi, Pelin Muhsir, Serap Demir
In this study, amine groups containing thiol-ene photocurable coating material for lipase immobilization were prepared. Lipase (EC from Candida rugosa was immobilized onto the photocured coatings by physical adsorption and glutaraldehyde-activated covalent bonding methods, respectively. The catalytic efficiency of the immobilized and free enzymes was determined for the hydrolysis of p-nitrophenyl palmitate and also for the synthesis of p-nitrophenyl linoleate. The storage stability and the reusability of the immobilized enzyme and the effect of temperature and pH on the catalytic activities were also investigated...
October 4, 2016: Applied Biochemistry and Biotechnology
Erhan Aysan, Ufuk Oguz Idiz, Leyla Elmas, Esra Kaytan Saglam, Zuleyha Akgun, Serap Baskaya Yucel
AIM: This study is aimed to evaluate the effects of boron on radiation-induced skin reactions (RISR) in breast cancer patients. MATERIAL AND METHODS: After 47 patients with invasive ductal carcinoma underwent radiotherapy, 23 (49%) received a boron-based gel, and 24 (51%) received placebo. Assessments were performed according to the Radiation Therapy Oncology Group (RTOG) skin scale and a Five-Point Horizontal Scale (FPHS). RESULTS: At the end of the fifth week of radiotherapy, the RTOG scores in the boron group were significantly lower than those in the placebo group (p = ...
October 4, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Neslihan Edeer Karaca, Guzide Aksu, Ezgi Ulusoy, Serap Aksoylar, Salih Gozmen, Ferah Genel, Sanem Akarcan, Nesrin Gulez, Tatjana Hirschmugl, Savas Kansoy, Kaan Boztug, Necil Kutukculer
Alterations of immune homeostasis in the gut may result in development of inflammatory bowel disease. A five-month-old girl was referred for recurrent respiratory and genitourinary tract infections, sepsis in neonatal period, chronic diarrhea, perianal abscess, rectovaginal fistula, and hyperemic skin lesions. She was born to second-degree consanguineous, healthy parents. Her elder siblings were lost at 4 months of age due to sepsis and 1 year of age due to inflammatory bowel disease, respectively. Absolute neutrophil and lymphocyte counts, immunoglobulin levels, and lymphocyte subsets were normal ruling out severe congenital neutropenia and classic severe combined immunodeficiencies...
2016: Case Reports in Immunology
Erkan Yıldırım, Emrah İpek, Işıl Bavunoğlu, Nilgün Yıldırım, Mahir Cengiz, Serap Yavuzer, Hakan Yavuzer, Hayriye Erman, Hafize Uzun
OBJECTIVE: The present study compared the unfavorable effects of protein oxidation and deoxyribonucleic acid damage on patients with white coat hypertension (WCH), sustained hypertension (HT), and normotensives. METHODS: Participants were allocated into 3 groups: 40 healthy controls, 36 patients with WCH, and 40 patients with sustained HT. Patients with risk factors for atherosclerosis, endocrine diseases, alcoholism, or masked hypertension were excluded. Plasma level of protein carbonyl (PCO), ischemia modified albumin (IMA), total thiol (T-SH), prooxidant-antioxidant balance (PAB), advanced protein oxidation products (AOPPs), and urinary level of 8-hydroxy-2'-deoxyguanosine (8-OHdG) were measured and relationship between these oxidative stress parameters and WCH and sustained HT was analyzed...
September 28, 2016: Anatolian Journal of Cardiology
Edward V Loftus, Jean-Frédéric Colombel, Brian G Feagan, Severine Vermeire, William J Sandborn, Bruce E Sands, Silvio Danese, Geert R D'Haens, Arthur Kaser, Remo Panaccione, David T Rubin, Ira Shafran, Megan McAuliffe, Arpeat Kaviya, Serap Sankoh, Reema Mody, Brihad Abhyankar, Michael Smyth
BACKGROUND AND AIMS: The GEMINI long-term safety (LTS) study is a continuing phase 3 trial investigating the safety and efficacy of vedolizumab, an α4β7 integrin antagonist for ulcerative colitis (UC) and Crohn's disease. We provide an interim analysis of efficacy in patients with UC. METHODS: Patients from the C13004 and GEMINI 1 studies and a cohort of vedolizumab-naïve patients received open-label vedolizumab every 4 weeks. Interim data were collected from 22 May 2009 to 27 June 2013...
September 28, 2016: Journal of Crohn's & Colitis
Severine Vermeire, Edward V Loftus, Jean-Frédéric Colombel, Brian G Feagan, William J Sandborn, Bruce E Sands, Silvio Danese, Geert R D'Haens, Arthur Kaser, Remo Panaccione, David T Rubin, Ira Shafran, Megan McAuliffe, Arpeat Kaviya, Serap Sankoh, Reema Mody, Brihad Abhyankar, Michael Smyth
BACKGROUND AND AIMS: Vedolizumab is a gut-selective α4β7 integrin antagonist therapy for ulcerative colitis and Crohn's disease. The GEMINI long-term safety (LTS) trial is an ongoing open-label study investigating the safety of vedolizumab. We present interim exploratory analyses of efficacy in patients with Crohn's disease. METHODS: Patients from the C13004, GEMINI 2, and GEMINI 3 studies and vedolizumab-naïve patients could enrol in GEMINI LTS and received vedolizumab every 4 weeks...
September 28, 2016: Journal of Crohn's & Colitis
Serap Süzük, Banu Kaşkatepe, Mustafa Çetin
The viridans group Streptococci (VGS) are most abundant in the mouth; in some instances they might emerge as pathogens particularly in infective endocarditis (IE). In this study, we aimed to define and determine the susceptibility against antibiotics of VGS that are members of the oral microbiota of patients exhibiting a risk of developing IE. Forty-nine patients at risk of infective endocarditis were included in the study. Identification of the bacteria was performed using API STREP (bioMérieux, France). Gradient test strips (E-Test, France) were used to determine MIC of the bacteria against penicillin, ampicillin, and vancomycin...
September 1, 2016: Le Infezioni in Medicina
Tuğba Kevser Uzunçakmak, Ayşe Serap Karadağ, Şeyma Özkanlı, Ebru Itır Zemheri, Mukaddes Kavala, Necmettin Akdeniz
The patient had visited various clinics for her complaints and was diagnosed as having contact dermatitis and senile pruritus. She was prescribed topical mometasone furoate and moisturizers. After 6 months of using this therapy, widespread grey-white plaques and minimal excoriation appeared on her face, scalp, and trunk. This was diagnosed as psoriasis, and the patient was prescribed topical corticosteroids, which she used for 9 months until she came to our clinic.
August 2016: Journal of Family Practice
Afra Ekinci, Tuba Yücel Uçarkuş, Aylin Okur, Mehmet Öztürk, Serap Doğan
PURPOSE: Pneumonia is an important cause of mortality and morbidity in immunocompromised patients. Computed tomography (CT) is the most sensitive imaging modality for the diagnosis and surveillance of these patients. Since CT exposes the patient to ionizing radiation, we investigated the utility of magnetic resonance imaging (MRI) in the diagnosis and surveillance of immunocompromised patients with pneumonia. METHODS: The study included 40 immunocompromised patients with pneumonia documented on CT...
September 9, 2016: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
Brian G Feagan, David T Rubin, Silvio Danese, Severine Vermeire, Brihad Abhyankar, Serap Sankoh, Alexandra James, Michael Smyth
BACKGROUND & AIMS: The efficacy and safety of vedolizumab, a humanized immunoglobulin G1 monoclonal antibody against the integrin α4β7, was demonstrated in multicenter, phase 3, randomized, placebo-controlled trials in patients with moderately to severely active ulcerative colitis (UC) or Crohn's disease. We analyzed data from 1 of these trials to determine the effects of vedolizumab therapy in patients with UC, based on past exposure to anti-tumor necrosis factor (TNF) agents. METHODS: We performed a post-hoc analysis data from the GEMINI 1 study, collected from 464 patients who received vedolizumab or placebo but had not received a previous TNF antagonist (naïve to TNF antagonists) and 367 patients with an inadequate response, loss of response, or intolerance to TNF antagonists (failure of TNF antagonists)...
September 14, 2016: Clinical Gastroenterology and Hepatology
Gul Devrimsel, Munevver Serdaroglu Beyazal, Aysegul Kucukali Turkyilmaz, Serap Baydur Sahin
[Purpose] The aim of this study was to investigate the effects of hypothyroidism on femoral cartilage thickness by using ultrasound, which has been found to be useful in the early diagnosis of knee osteoarthritis. [Subjects and Methods] Forty patients diagnosed with hypothyroidism and 30 age-, gender-, smoking status, physical activity-, and body mass index-matched healthy subjects were enrolled. The thickness of the femoral articular cartilage was measured using a 7- to 12-MHz linear probe. Three mid-point measurements were taken from each knee at the lateral condyle, intercondylar area, and medial condyle...
August 2016: Journal of Physical Therapy Science
Merritt Weaver Brown, Tülin Serap Yilmaz, Ekkehard M Kasper
BACKGROUND: Lumbar puncture (LP) rarely results in complications such as spinal hematomas. However, it remains unclear if certain variables increase likelihood of these events, or if surgical intervention improves outcome. METHODS: In addition to two clinical vignettes, we evaluated the post-1974 literature for cases of spinal hematoma and subsequent intervention. Based on our compilation of data, we evaluated outcome relative to numerous distinct variables. RESULTS: Based on 35 LP-related spinal hematoma cases in the post-1974 literature and our encounters, we found 28...
2016: Surgical Neurology International
Yasemin Cag, Derya Ozturk-Engin, Serap Gencer, Rodrigo Hasbun, Gonul Sengoz, Alexandru Crisan, Nurgul Ceran, Branislava Savic, Kadriye Yasar, Filiz Pehlivanoglu, Gamze Kilicoglu, Hulya Tireli, Ayse S Inal, Rok Civljak, Recep Tekin, Nazif Elaldi, Aysegul Ulu-Kilic, Muge Ozguler, Mustafa Namiduru, Mustafa Sunbul, Oguz R Sipahi, Olga Dulovic, Selma Alabay, Ayhan Akbulut, Alper Sener, Botond Lakatos, Katell Andre, Mucahit Yemisen, Serkan Oncu, Mihai Nechifor, Ozcan Deveci, Seniha Senbayrak, Asuman Inan, Gorana Dragovac, Hanefi C G L, Gurkan Mert, Oral Oncul, Bahar Kandemir, Serpil Erol, Canan Agalar, Hakan Erdem
AIMS: There is no report on the factors affecting the resolution of symptoms related to meningitis during treatment of tuberculous meningitis (TBM). Thus, we examined the factors associated with early therapeutic responses. MATERIALS AND METHODS: This multicenter study included 507 patients with microbiologically confirmed TBM. However, 94 patients eligible for the analysis were included in this study from 24 centers. Six out of 94 patients died and the statistical analysis was performed with 88 survivors...
September 2016: Neurology India
Ayse S Karadag, Tuğba K Uzunçakmak, Seyma Ozkanli, Serpil Oguztuzun, Busra Moran, Ozge Akbulak, Emin Ozlu, Itir E Zemheri, Serap G Bilgili, Necmettin Akdeniz
Oxidative stress may play an important role in the pathogenesis of psoriasis. Glutathione S-transferases (GSTs) make up a group of antioxidant enzymes. Cytochrome p450 (CYP) enzymes can influence oxidation and reduction reactions. We investigated the potential effects of GST and CYP enzymes in the pathogenesis of psoriasis. The study included 32 psoriasis patients and 22 healthy subjects. Psoriasis patients were administered 20 sessions of narrowband ultraviolet B phototherapy. Expressions of GST and CYP enzymes were assessed by immunohistochemical staining...
September 9, 2016: International Journal of Dermatology
Serap Köybaşı Şanal, Yusuf Özgür Biçer, Aysel Kükner, Erkan Tezcan
BACKGROUND: Voice may be affected during the period of pregnancy, especially in the third trimester. However, the exact mechanisms leading to the phonatory changes have not yet uncovered. AIMS: The aim of this study is to investigate the possible histological changes in the vocal cords of the pregnant rats in three separate trimesters. STUDY DESIGN: Animal experiment. METHODS: Twenty-five Wistar-Albino female rats were divided into four groups: control group, pregnancy day 7 (Group 1), pregnancy day 14 (Group 2) and pregnancy day 20 (Group 3)...
July 2016: Balkan Medical Journal
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