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https://www.readbyqxmd.com/read/28081353/clinical-correlation-between-the-6-min-walk-test-andcardiopulmonary-exercise-testing-in-patients-with-pulmonary-arterial-hypertension
#1
Serap Acar, Sema Savcı, Didem Kardibak, Buse Özcan Kahraman, Bahri Akdeniz, Ebru Özpelit, Can Sevinç
BACKGROUND/AIM: The aims of the present study were to assess the relationship between the distance walked during the 6-min walk test (6MWT) and exercise capacity as determined by cardiopulmonary exercise testing (CPET) in patients with pulmonary arterial hypertension (PAH) and to investigate the prognostic value of the 6MWT in comparison to clinical parameters of CPET and echocardiography findings. MATERIALS AND METHODS: Thirty PAH patients participated in the study...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28079523/symbiont-induced-odorant-binding-proteins-mediate-insect-host-hematopoiesis
#2
Joshua B Benoit, Aurélien Vigneron, Nichole A Broderick, Yineng Wu, Jennifer S Sun, John R Carlson, Serap Aksoy, Brian L Weiss
Symbiotic bacteria assist in maintaining homeostasis of the animal immune system. However, the molecular mechanisms that underlie symbiont-mediated host immunity are largely unknown. Tsetse flies (Glossina spp.) house maternally transmitted symbionts that regulate the development and function of their host's immune system. Herein we demonstrate that the obligate mutualist, Wigglesworthia, up-regulates expression of odorant binding protein six in the gut of intrauterine tsetse larvae. This process is necessary and sufficient to induce systemic expression of the hematopoietic RUNX transcription factor lozenge and the subsequent production of crystal cells, which actuate the melanotic immune response in adult tsetse...
January 12, 2017: ELife
https://www.readbyqxmd.com/read/28078915/synthesis-and-characterization-of-thermosensitive-poly-n-vinylcaprolactam-g-collagen
#3
Serap Durkut, Yaşar Murat Elçin
In this study, we synthesized poly(N-vinylcaprolactam)-g-collagen (PNVCL-g-Col) by grafting collagen with carboxyl group-terminated thermosensitive PNVCL-COOH. The resulting biopolymer was evaluated for its structural, thermal, and rheological properties. Aqueous solutions of PNVCL-g-Col exhibited a temperature-dependent phase transition around human physiological temperature (at ∼38.5 °C), and temperature-dependent tunability. PNVCL-g-Col exhibited temperature-dependent release of the model drugs, lidocaine hydrochloride and bovine serum albumin...
January 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28076993/evaluation-of-clinical-and-serological-findings-for-diagnosis-of-cutaneous-anthrax-infection-after-an-outbreak
#4
Duygu Gulseren, Serap Süzük-Yıldız, Bekir Çelebi, Selçuk Kılıç
PURPOSE: Anthrax, caused by the bacterium Bacillus anthracis, is one of the oldest documented infectious diseases in both livestock and humans.We aimed to evaluate clinical findings and risk factors of patients with cutaneous anthrax infection and report anti-lethal factor (LF) IgG and anti-protective antigene (PA) IgG titers in the serologic diagnosis of disease. METHODS: In this study, serum samples of 18 cutaneous anthrax patients were collected and anti-LF IgG and anti-PA IgG titers were measured by enzyme-linked immunosorbent assay (ELISA)...
January 11, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28067065/the-investigation-of-antimicrobial-peptides-expression-and-its-related-interaction-with-methotrexate-treatment-in-patients-with-psoriasis-vulgaris
#5
Emin Ozlu, Ayse Serap Karadag, Seyma Ozkanli, Serpil Oguztuzun, Ozge Akbulak, Tugba Kevser Uzuncakmak, Serkan Demirkan, Necmettin Akdeniz
BACKGROUND: Psoriasis is a chronic, inflammatory and immune-mediated disease. Recently, the role of antimicrobial peptides (AMPs) such as human beta defensins (hBDs) in the pathogenesis of psoriasis has been investigated. We aimed to evaluate the expression profiles of hBD-1 and hBD-2 in psoriatic skin before and after methotrexate (MTX) therapy and to compare healthy controls. METHODS: Immunohistochemical expressions of hBD-1 and hBD-2 were assessed in 16 patients with psoriasis vulgaris and 20 normal skin biopsies from healthy controls...
January 8, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28065360/intracavernous-injection-of-human-umbilical-cord-blood-mononuclear-cells-improves-erectile-dysfunction-in-streptozotocin-induced-diabetic-rats
#6
Tugba Cengiz, Ecem Kaya, Didem Yilmaz Oral, Isil Ozakca, Nur Bayatli, Arzu Zeynep Karabay, Tugba Altun Ensari, Tuna Karahan, Enis Yilmaz, Serap Gur
INTRODUCTION: Erectile dysfunction (ED) worsens in men with diabetes. Human umbilical cord blood (HUCB), because of its widespread availability and low immunogenicity, is a valuable source for stem cell-based therapies. AIM: To determine the effect of intracavernous injection of HUCB mononuclear cells (MNCs) on ED in rats with diabetes induced by streptozotocin. METHODS: Thirty adult male Sprague-Dawley rats were equally divided into three groups: (i) control, (ii) diabetes induced by streptozotocin (35 mg/kg intravenously for 8 weeks), and (iii) diabetic rats treated with MNCs (1 × 10(6) cells by intracavernosal injection)...
January 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28062904/turkish-adaptation-of-the-pelvic-organ-prolapse-symptom-score-and-its-validity-and-reliability
#7
Nuriye Özengin, Serap Kaya, Ceren Orhan, Yeşim Bakar, Bülent Duran, Handan Ankaralı, Türkan Akbayrak
INTRODUCTION AND HYPOTHESIS: The purpose of this study was to adapt the Pelvic Organ Prolapse Symptom Score (POP-SS) into Turkish and evaluate its reliability and validity. METHODS: The POP-SS was adapted into Turkish by following the steps of the intercultural adaptation process. One hundred and three women with symptomatic or asymptomatic pelvic organ prolapse (POP) completed the Turkish POP-SS and other valid and reliable Turkish tools for POP: Pelvic Organ Prolapse Distress Inventory 6 (POPDI-6), Colorectal-Anal Distress Inventory 8 (CRADI-8), Urinary Distress Inventory 6 (UDI-6), Pelvic Floor Distress Inventory 20 (PFDI-20), and Pelvic Organ Prolapse Impact Questionnaire 7 (POPIQ-7)...
January 6, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28060566/the-role-of-ultrasonography-in-the-assessment-of-vocal-cord-functions-after-thyroidectomy
#8
Murat Ö Kılıç, Serdar G Terzioğlu, Serap Y Gülçek, Engin Sarı
No abstract text is available yet for this article.
January 6, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28052712/the-effects-of-perinatal-steroid-therapy-on-growth-factor-levels-during-different-stages-of-the-developing-brain
#9
Burçin İşcan, Funda Tuzun, Serap Cilaker Micili, Kazim Tugyan, Nuray Duman, Hasan Ozkan, Abdullah Kumral
OBJECTIVE: Excess glucocorticoid exposure on the fetal brain during critical stages of development has considerable effects on the development of the central nervous system. This study thus aimed to evaluate the differential effects of glucocorticoid exposure on critical growth factor levels during different stages of brain maturation. METHODS: For this purpose, forty-two rat pups were divided into six groups based on the timing of betamethasone administration. Rats in the treatment groups were exposed to intraperitoneal betamethasone injections beginning at different time points (postnatal days 1, 2, and 3)...
January 4, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28032266/aflatoxin-m1-in-human-breast-milk-in-southeastern-turkey
#10
Serap Kılıç Altun, Semra Gürbüz, Emin Ayağ
This study was performed to determine aflatoxin M1 (AFM1) in human breast milk samples collected in Şanlıurfa, located in Southeastern region of Turkey, and to investigate a possible correlation between AFM1 occurrence (frequency and levels) and sampling seasons. Human breast milk samples collected in December 2014 and in June 2015 from a total of 74 nursing women, both outpatient and inpatient volunteers in hospitals located in Şanlıurfa, Turkey, were analyzed using competitive enzyme-linked immunosorbent assay (ELISA) for the presence of AFM1...
December 28, 2016: Mycotoxin Research
https://www.readbyqxmd.com/read/28025756/the-longitudinal-relation-between-daily-hassles-and-depressive-symptoms-among-unaccompanied-refugees-in-norway
#11
Serap Keles, Thormod Idsøe, Oddgeir Friborg, Selcuk Sirin, Brit Oppedal
The aim of the present longitudinal study is to understand the longitudinal relation between depressive symptoms and daily hassles (i.e., general and acculturation hassles) in a high-risk population of unaccompanied refugees. We investigated the validity of three stress-mental health models: the stress exposure model, the stress generation model, and the reciprocal model. Data were collected from 918 unaccompanied refugees in Norway in three waves. Of the initial sample, the majority (82.1%) were male (M age = 19...
December 26, 2016: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28005808/spontaneous-epidural-pneumocephalus
#12
Serap Yucel, Hediye Pinar Gunbey, Gökhan Kutlar, Mustafa Ozdemir, Kerim Aslan, Lutfi Incesu
Spontaneous epidural pneumocephalus is a rare condition. The authors reported a 35-year-old male patient with tinnutus, dull headache, and swelling on his head. Patient had a history of head trauma and skull fracture from when he was 5 years old. Cranial computed tomography revealed increase in pneumatization of right mastoid air cells and large epidural air in temporoparietal region. Inner table of right temporal bone got thinner, causing communication of mastoid air cells with epidural space. Epidural air had septations and exerted mass effect on the right parietal lobe with minimal midline shift...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28005786/the-comparison-of-the-efficacy-of-blue-light-emitting-diode-light-and-980-nm-low-level-laser-light-on-bone-regeneration
#13
Ömür Dereci, Alper Sindel, Havva Serap Toru, Esra Yüce, Sinan Ay, Sinan Tozoğlu
The aim of this study is to histologically compare effects of blue light-emitting diode (LED) light (400-490 nm) and Ga-Al-As low-level diode laser light (980 nm) on bone regeneration of calvarial critical-sized defects in rats. Thirty Wistar Albino rats were included in the study. The experimental groups were as follows: blue LED light (400-490 nm) group (LED); 980-nm low-level laser light group (LL); and no-treatment, control group (CL). A critical-sized defect of 8 mm was formed on calvaria of rats...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28004987/determining-the-level-and-cost-of-sickness-presenteeism-among-hospital-staff-in-turkey
#14
Kandemir Aysun, Şahin Bayram, Taşkaya Serap
OBJECTIVE: This study aimed to determine the associations between sickness presenteeism and socio-demographic factors, perceived health status and health complaints among hospital staff and to calculate the cost burdens and productivity losses attributed to presenteeism. METHODS: A cross-sectional study was conducted using 951 hospital staff, including physicians, nurses, midwives, other health personnel and administrative staff working in two hospitals that are located in Kırıkkale province in Turkey...
December 22, 2016: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/28002435/transcriptome-profiling-of-trypanosoma-brucei-development-in-the-tsetse-fly-vector-glossina-morsitans
#15
Amy F Savage, Nikolay G Kolev, Joseph B Franklin, Aurelien Vigneron, Serap Aksoy, Christian Tschudi
African trypanosomes, the causative agents of sleeping sickness in humans and nagana in animals, have a complex digenetic life cycle between a mammalian host and an insect vector, the blood-feeding tsetse fly. Although the importance of the insect vector to transmit the disease was first realized over a century ago, many aspects of trypanosome development in tsetse have not progressed beyond a morphological analysis, mainly due to considerable challenges to obtain sufficient material for molecular studies. Here, we used high-throughput RNA-Sequencing (RNA-Seq) to profile Trypanosoma brucei transcript levels in three distinct tissues of the tsetse fly, namely the midgut, proventriculus and salivary glands...
2016: PloS One
https://www.readbyqxmd.com/read/27995496/neuroprotective-effect-of-erythropoietin-on-phenylhydrazine-induced-hemolytic-hyperbilirubinemia-in-neonatal-rats
#16
Asli Memisoglu, Meltem Kolgazi, Akan Yaman, Elif Bahadir, Serap Sirvanci, Berrak Ç Yeğen, Eren Ozek
Neonatal unconjugated hyperbilirubinemia might cause severe bilirubin neurotoxicity in especially hemolytic conditions. The study aimed to elucidate the potential neuroprotective effects of erythropoietin (EPO) in hemolysis-induced hyperbilirubinemia. In newborn rats, hyperbilirubinemia secondary to hemolysis was induced by injecting with phenylhydrazine hydrochloride (PHZ) and rats were injected with either vehicle or EPO. At 54th hour of the PHZ injection, rats were decapitated. Serum levels of TNF-α, IL-1β, IL-10, brain-derived neurotrophic factor (BDNF) and S100-B and brain malondialdehyde, glutathione levels and myeloperoxidase activities were measured...
December 19, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27994924/correlation-between-amitriptyline-induced-cardiotoxic-effects-and-cardiac-s100b-protein-in-isolated-rat-hearts
#17
Nil Hocaoğlu, Nergis Murat, Serap Cilaker Mıcılı, Burç Aydın, Bekir Uğur Ergür, Şule Kalkan
BACKGROUND: Amitriptyline is an important cause of mortality due to its cardiovascular toxicity. AIMS: To investigate the changes in levels of cardiac S100b protein on amitriptyline-induced cardiotoxicity and also to examine the correlation between amitriptyline-induced cardiotoxic effects and cardiac S100b protein in an isolated rat heart model. STUDY DESIGN: Animal experimentation, isolated heart model. METHODS: After a stabilization period, isolated hearts were randomized to two groups (n=5 and n=7)...
November 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27994921/the-burden-of-premature-mortality-in-turkey-in-2001-and-2008
#18
Burcu Tokuç, Serap Ayhan, Gamze Varol Saraçoğlu
BACKGROUND: Standard expected years of life lost (SEYLL) is a measure that is used to evaluate losses due to premature deaths. AIMS: The present study provides an analysis of premature mortality in Turkey for the years 2001 and 2008 and supplies evidence for making policies and setting health agendas over the long term. STUDY DESIGN: Cross-sectional study. METHODS: This study calculated SEYLL by gender, age group and causes of death in Turkey in 2014...
November 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27994151/dynamic-nherf-interaction-with-trpc4-5-proteins-is-required-for-channel-gating-by-diacylglycerol
#19
Ursula Storch, Anna-Lena Forst, Franziska Pardatscher, Serap Erdogmus, Maximilian Philipp, Manuel Gregoritza, Michael Mederos Y Schnitzler, Thomas Gudermann
The activation mechanism of the classical transient receptor potential channels TRPC4 and -5 via the Gq/11 protein-phospholipase C (PLC) signaling pathway has remained elusive so far. In contrast to all other TRPC channels, the PLC product diacylglycerol (DAG) is not sufficient for channel activation, whereas TRPC4/5 channel activity is potentiated by phosphatidylinositol 4,5-bisphosphate (PIP2) depletion. As a characteristic structural feature, TRPC4/5 channels contain a C-terminal PDZ-binding motif allowing for binding of the scaffolding proteins Na(+)/H(+) exchanger regulatory factor (NHERF) 1 and 2...
January 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27979286/use-of-raman-spectroscopy-for-determining-erucic-acid-content-in-canola-oil
#20
Serap Durakli Velioglu, Havva Tumay Temiz, Elif Ercioglu, Hasan Murat Velioglu, Ali Topcu, Ismail Hakki Boyaci
This study presents a novel method to determine erucic acid in canola oil samples by using Raman spectroscopy and chemometric analysis. The oil mixtures were prepared at various concentrations of erucic acid ranging from 0% to 33.56% (w/w) through binary combinations of different oils. In order to predict erucic acid content, Raman spectroscopy and GC results were correlated by means of partial least squares analysis. High coefficient of determination values was obtained for both calibration and validation data sets, which are 0...
April 15, 2017: Food Chemistry
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