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breast, cancer, preeclampsia

Klara Piletič, Tanja Kunej
MicroRNAs (miRNAs) are short non-coding RNAs that act as important regulators of gene expression as part of the epigenetic machinery. In addition to posttranscriptional gene silencing by miRNAs, the epigenetic mechanisms also include DNA methylation, histone modifications and their crosstalk. Epigenetic modifications were reported to play an important role in many disease onsets and progressions and can be used to explain several features of complex diseases, such as late onset and fluctuation of symptoms. However, miRNAs not only function as a part of epigenetic machinery, but are also epigenetically modified by DNA methylation and histone modification like any other protein-coding gene...
October 2016: Archives of Toxicology
B P Foster, T Balassa, T D Benen, M Dominovic, G K Elmadjian, V Florova, M D Fransolet, A Kestlerova, G Kmiecik, I A Kostadinova, C Kyvelidou, M Meggyes, M N Mincheva, L Moro, J Pastuschek, V Spoldi, P Wandernoth, M Weber, B Toth, U R Markert
Extracellular vesicles (EVs) are released from almost all cells and tissues. They are able to transport substances (e.g. proteins, RNA or DNA) at higher concentrations than in their environment and may adhere in a receptor-controlled manner to specific cells or tissues in order to release their content into the respective target structure. Blood contains high concentrations of EVs mainly derived from platelets, and, at a smaller amount, from erythrocytes. The female and male reproductive tracts produce EVs which may be associated with fertility or infertility and are released into body fluids and mucosas of the urogenital organs...
December 2016: Critical Reviews in Clinical Laboratory Sciences
Cornelia Muschol-Steinmetz, Britta Jasmer, Nina-Naomi Kreis, Kerstin Steinhäuser, Andreas Ritter, Udo Rolle, Juping Yuan, Frank Louwen
Preeclampsia is one of the leading causes of maternal and perinatal mortality and morbidity and its pathogenesis is not fully understood. B-cell lymphoma 6 (BCL6), a key regulator of B-lymphocyte development, is altered in preeclamptic placentas. We show here that BCL6 is present in all 3 studied trophoblast cell lines and it is predominantly expressed in trophoblastic HTR-8/SVneo cells derived from a 1(st) trimester placenta, suggestive of its involvement in trophoblast expansion in the early stage of placental development...
2016: Cell Cycle
Mohammadhossein Hajiebrahimi, Sven Cnattingius, Mats Lambe, Shahram Bahmanyar
BACKGROUND: Reproductive factors are well-known risk factors for premenopausal breast cancer (PBC). It is unknown whether these associations are modified by familial factors, including genetic and early environment factors. METHODS: Using Swedish health registries, we performed a nested case-control study with two control groups: sister controls and population controls. The study population included women with live singleton births between 1973 and 2010, who also had a full sister who gave birth during this period...
June 2016: International Journal of Epidemiology
Melanie Audette, Kalpana Pillai, Jeff Wrana, John Kingdom
No abstract text is available yet for this article.
August 2015: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
Nadja Livia Pekkola Pacheco, Anne-Marie Nybo Andersen, Mads Kamper-Jørgensen
BACKGROUND: In parous women preeclampsia has been associated with reduced risk of developing breast cancer. Characteristics of births following preeclamptic pregnancies may help understand mechanisms involved in the breast cancer risk reduction inferred by preeclampsia. METHODS: We conducted a register-based cohort study of all Danish women giving birth during 1978-2010 (n = 778,701). The association between preeclampsia and breast cancer was evaluated overall and according to birth characteristics by means of incidence rate ratios (IRR) estimated in Poisson regression models...
October 2015: Breast: Official Journal of the European Society of Mastology
Francesca Colonese, Antonio Simone Laganà, Elisabetta Colonese, Vincenza Sofo, Francesca Maria Salmeri, Roberta Granese, Onofrio Triolo
The traditionally recognized role of vitamin D consists in the regulation of bone metabolism and calcium-phosphorus homeostasis but recently a lot of in vitro and in vivo studies recognized several "noncalcemic" effects of vitamin D metabolites. Accumulating evidence suggests that the metabolic pathways of this vitamin may play a key role in the developing of gynaecological/obstetric diseases. VDR-mediated signalling pathways and vitamin D levels seem to (deeply) affect the risk of several gynaecological diseases, such as polycystic ovary syndrome (PCOS), endometriosis, and ovarian and even breast cancer...
2015: BioMed Research International
Lene G Rasmussen, Jacob A Lykke, Anne C Staff
We review diagnostic and predictive roles of the angiogenic proteins placental growth factor, soluble fms-like tyrosine kinase 1, and soluble endoglin in preeclampsia, and their association with future cardiovascular disease, diabetes, and breast cancer. Specific patterns of these proteins represent preeclamptic prediction markers and combined with maternal and clinical characteristics, the predictive values increase. Women experiencing preeclampsia have increased risks of developing cardiovascular diseases and diabetes, and a decreased risk of breast cancer...
August 2015: Acta Obstetricia et Gynecologica Scandinavica
Jeremy Michals Schraw, Bjorn Øgland, Yong Quan Dong, Stein Tore Nilsen, Michele R Forman
Cord blood insulin-like growth factor-1 (IGF-1) concentrations are lower in preeclamptic (PE) than normotensive (NT) pregnancies. PE offspring have increased risk of cardiovascular disease and decreased risk of some cancers including breast. We examined the effects of PE exposure in utero, infant feeding and childhood diet at 3-5 years on IGF-1 and breast development in 194 female offspring who were followed from birth until follow-ups at 10.8 and 12.9 years. Diet was not associated with serum IGF-1 levels at 10...
July 2015: Reproductive Toxicology
Jessica M Faupel-Badger, Thomas F McElrath, Michele Lauria, Lauren C Houghton, Kee-Hak Lim, Samuel Parry, David Cantonwine, Gabriel Lai, S Ananth Karumanchi, Robert N Hoover, Rebecca Troisi
OBJECTIVE: The purpose of this study was to compare longitudinally sampled maternal angiogenic proteins between singleton and twin pregnancies. STUDY DESIGN: Placental growth factor (PlGF), soluble feline McDonough sarcoma (fms)-like tyrosine kinase (sFlt)-1, and soluble endoglin from healthy pregnant women were quantified at 10, 18, 26, and 35 weeks' gestation (n=91), and during the third trimester (31-39 weeks) and at delivery (33-41 weeks; n=41). Geometric means and 95% confidence intervals were calculated for gestational age-adjusted angiogenic protein concentrations and compared between matched twin and singleton pregnancies...
May 2015: American Journal of Obstetrics and Gynecology
Li Qiu, Sagano Onoyama, Hoi Pang Low, Chien-I Chang, William C Strohsnitter, Errol R Norwitz, Mary Lopresti, Kathryn Edmiston, Mats Lambe, Dimitrios Trichopoulos, Pagona Lagiou, Chung-Cheng Hsieh
Women born from a preeclamptic (PE) pregnancy are associated with a lower risk of breast cancer. Prenatal and early-life exposures are hypothesized to influence breast cancer susceptibility through their effect on stem cells. We examined stem cell populations in umbilical cord blood from PE pregnancies and compared with those from pregnancies without this condition. We isolated mononuclear cells from 58 PE and 197 normotensive (non-PE) umbilical cord blood samples and examined the different stem cell populations...
January 2015: Carcinogenesis
C Mounier-Vehier, F Boudghene, P Delsart, G Claisse, N Kpogbemadou, V Debarge, B Letombe
Cardiovascular (CV) diseases are the primary cause of death of women. Since they kill 10 times more than breast cancer, preventive measures should be implemented. According to U.S. recommendations, a woman is either at "CV risk" or at "optimal health status" if she has no risk factors and a perfectly healthy lifestyle. Some risk factors are more deleterious to women (smoking, diabetes, stress, depression, atrial fibrillation); or specific to women (preeclampsia, gestational diabetes, contraception, menopause, headaches)...
June 2014: Annales de Cardiologie et D'angéiologie
Martha Hickey, Roger Hart, Jeffrey A Keelan
BACKGROUND: Prenatal estrogen exposure is thought to contribute to later life diseases such as breast cancer. However, few studies have directly measured prenatal estrogens and most have relied on proposed "markers" of estrogen exposure. We used a large population-based birth cohort to directly measure the relationship between prenatal estrogens and perinatal characteristics, including putative markers of estrogen exposure. METHODS: Total estrone (E1), estradiol (E2), estriol (E3), and estetrol (E4) were assayed by liquid chromatography/tandem mass spectrometry from archived mixed arterial and venous serum from 860 umbilical cord blood samples...
June 2014: Cancer Epidemiology, Biomarkers & Prevention
Hoi Pang Low, Ashutosh Tiwari, Jagadeesh Janjanam, Li Qiu, Chien-I Chang, William C Strohsnitter, Errol R Norwitz, Sun W Tam, James E Evans, Karin M Green, Joao A Paulo, Mats Lambe, Chung-Cheng Hsieh
Preeclampsia, a complication of pregnancy characterized by hypertension and proteinuria, has been found to reduce the subsequent risk for breast cancer in female offspring. As this protective effect could be due to exposure to preeclampsia-specific proteins during intrauterine life, the proteomic profiles of umbilical cord blood plasma between preeclamptic and normotensive pregnancies were compared. Umbilical cord plasma samples, depleted of 14 abundant proteins, were subjected to proteomic analysis using the quantitative method of nanoACQUITY ultra performance liquid chromatography-mass spectrometry with elevated energy mode of acquisition(E) (NanoUPLC-MS(E))...
December 2013: Genomics, Proteomics & Bioinformatics
R Troisi, T Grotmol, J Jacobsen, S Tretli, H Toft-Sørensen, M Gissler, R Kaaja, N Potischman, A Ekbom, R N Hoover, O Stephansson
The in utero origins of breast cancer are an increasing focus of research. However, the long time period between exposure and disease diagnosis, and the lack of standardized perinatal data collection makes this research challenging. We assessed perinatal factors, as proxies for in utero exposures, and breast cancer risk using pooled, population-based birth and cancer registry data. Birth registries provided information on perinatal exposures. Cases were females born in Norway, Sweden or Denmark who were subsequently diagnosed with primary, invasive breast cancer (n = 1419)...
February 2013: Journal of Developmental Origins of Health and Disease
Kiley A Bernhard, Danish S Siddiqui, Kinsey M Leonard, Suneet P Chauhan
OBJECTIVE: To ascertain the influence and utilization of the American College Obstetricians and Gynecologists practice bulletins (PBs) by measuring their citations in three different search tools. STUDY DESIGN: PBs in obstetrics (OB-PBs) and gynecology (GYN-PBs) published from September 1998 to December 2009 were identified. PubMed, Ovid MEDLINE, and Web of Science were utilized to determine how often PBs were cited. The citations were quantified by three parameters, most citations, highest citation rate, and highest impact factor...
May 2014: American Journal of Perinatology
Theodore M Brasky, Yanli Li, David J Jaworowicz, Nancy Potischman, Christine B Ambrosone, Alan D Hutson, Jing Nie, Peter G Shields, Maurizio Trevisan, Carole B Rudra, Stephen B Edge, Jo L Freudenheim
Breast tissues undergo extensive physiologic changes during pregnancy, which may affect breast carcinogenesis. Gestational hypertension, preeclampsia/eclampsia, gestational diabetes, pregnancy weight gain, and nausea and vomiting (N&V) during pregnancy may be indicative of altered hormonal and metabolic profiles and could impact breast cancer risk. Here, we examined associations between these characteristics of a woman's pregnancy and her subsequent breast cancer risk. Participants were parous women that were recruited to a population-based case-control study (Western New York Exposures and Breast Cancer Study)...
September 2013: Cancer Causes & Control: CCC
Agnès J Ditisheim, Charna Dibner, Jacques Philippe, Antoinette Pechère-Bertschi
The impact of impaired circadian rhythm on health has been widely studied in shift workers and trans-meridian travelers. A part from its correlation with sleep and mood disorders, biological rhythm impairment is a recognized risk factor for cardiovascular diseases and breast cancer. Preeclampsia is a major public health issue, associated with a significant maternal and fetal morbidity and mortality worldwide. While the risks factors for this condition such as obesity, diabetes, pre-existing hypertension have been identified, the underlying mechanism of this multi-factorial disease is yet not fully understood...
2013: Frontiers in Endocrinology
Vandana Dhaka, Neelam Gulia, Kulveer Singh Ahlawat, Bhupender Singh Khatkar
Trans fatty acids have the presence of one or more double bonds in the trans configuration instead of the usual cis configuration. They are desired by Vanaspati industry as they impart firmness to margarines and plasticity as well as emulsion stability to shortenings. Research has proved the direct connection of trans fatty acids with cardiovascular diseases, breast cancer, shortening of pregnancy period, risks of preeclampsia, disorders of nervous system and vision in infants, colon cancer, diabetes, obesity and allergy...
October 2011: Journal of Food Science and Technology
Ying Chen, Jun Miyazaki, Haruki Nishizawa, Hiroki Kurahashi, Richard Leach, Kai Wang
Secreted by the placental trophoblast, human chorionic gonadotropin (hCG) is an important hormone during pregnancy and is required for the maintenance of pregnancy. Previous studies have shown that dys-regulation of hCG expression is associated with preeclampsia. However, the exact relationship between altered hCG levels and development of preeclampsia is unknown. Metastasis associated protein 3 (MTA3), a chromatin remodeling protein, is abundantly expressed in the placental trophoblasts, but its function is unknown...
April 19, 2013: Biochemical and Biophysical Research Communications
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