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Smad7 AND Corilagin

Fan Yang, Yao Wang, Jun Xue, Qian Ma, Juan Zhang, Yun-Fei Chen, Zhen-Zhong Shang, Quan-Qiang Li, Shu-Ling Zhang, Lei Zhao
This study sought to investigate the anti-fibrotic effect of Corilagin via interference with the miR-21/smad7/ERK signaling pathway in a schistosomiasis-induced hepatic fibrosis mouse model. Mice were infected with Schistosoma japonicum cercaria to establish the mouse model of schistosomiasis-induced hepatic fibrosis. At four weeks after infection, the groups were given different medications. The living conditions were observed. Real-time PCR was employed to detect the mRNA levels of miR-21, smad7 and connective tissue growth factor (CTGF), and western blotting was used to examine the protein levels of smad7, CTGF, smad1, p-smad1, smad2, p-smad2, ERK1/2, p-ERK1/2 and TGF-β receptor I...
August 2016: Parasitology International
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