Ning Yan, Li Wen, Rui Peng, Hongmei Li, Handeng Liu, Huimin Peng, Yan Sun, Tianhui Wu, Lei Chen, Qingrui Duan, Yixuan Sun, Qin Zhou, Lijiang Wei, Zheng Zhang
Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus (DM). However, the exact mechanism is not clearly understood. In this study, our results showed that 24 h urinary protein, kidney index, and glomerular area were decreased, while creatinine clearance ratio was increased in DN rats when the rats were treated with NAR 50 mg/d for 6 weeks. Mesangial cell (MMCs) proliferation was inhibited in the NAR group by 3,(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), and the cell cycle analysis showed that cells stayed in G2 phase in NAR group...
2016: Journal of Diabetes Research