keyword
https://read.qxmd.com/read/38493076/metabolic-reprogramming-in-the-cll-tme-potential-for-new-therapeutic-targets
#1
JOURNAL ARTICLE
Helga Simon-Molas, Chiara Montironi, Anna Kabanova, Eric Eldering
Chronic lymphocytic leukemia (CLL) cells circulate between peripheral (PB) blood and lymph node (LN) compartments, and strictly depend on microenvironmental factors for proliferation, survival and drug resistance. All cancer cells display metabolic reprogramming and CLL is no exception - though the inert status of the PB CLL cells has hampered detailed insight into these processes. We summarize previous work on reactive oxygen species (ROS), oxidative stress, and hypoxia, as well as the important roles of Myc, and PI3K/Akt/mTor pathways...
February 15, 2024: Seminars in Hematology
https://read.qxmd.com/read/38492879/skeletal-muscle-atrophy-after-sciatic-nerve-damage-mechanistic-insights
#2
REVIEW
Aarti Yadav, Rajesh Dabur
Sciatic nerve injury leads to molecular events that cause muscular dysfunction advancement in atrophic conditions. Nerve damage renders muscles permanently relaxed which elevates intracellular resting Ca2+ levels. Increased Ca2+ levels are associated with several cellular signaling pathways including AMPK, cGMP, PLC-β, CERB, and calcineurin. Also, multiple enzymes involved in the tricarboxylic acid cycle and oxidative phosphorylation are activated by Ca2+ influx into mitochondria during muscle contraction, to meet increased ATP demand...
March 14, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38490509/targeting-camk2n1-camk2-inhibits-invasion-migration-and-angiogenesis-of-non-small-cell-lung-cancer-by-promoting-autophagy-and-apoptosis-via-akt-mtor-signaling-pathway
#3
JOURNAL ARTICLE
Qiang Wang, Chao Zhang, Hai Jiang, Weiyang He
Deregulation of calcium/calmodulin-dependent protein kinase II (CAMK2) inhibitor 1 (CAMK2N1) has been reported to be associated with the development of several malignancies. To date, there have been few studies on the role of CAMK2N1 in lung cancer. This study aimed to investigate the relationship between CAMK2N1 and the progression of non-small cell lung cancer (NSCLC). Methodological quality was assessed using the ARRIVE guidelines. CAMK2N1 was expressed at low levels in NSCLC tissues. Overexpression of CAMK2N1 in NSCLC cell lines resulted in changes such as proliferation inhibition, metastasis inhibition, autophagy increase, and apoptosis...
March 13, 2024: Gene
https://read.qxmd.com/read/38490290/the-molecular-mechanism-of-action-for-the-potent-antitumor-component-extracted-using-supercritical-fluid-extraction-from-croton-crassifolius-root
#4
JOURNAL ARTICLE
Xu Guo, Rui-Rui Zhang, Jin-Yue Sun, Yan Liu, Xian-Shun Yuan, Ying-Ying Chen, Hui Sun, Chao Liu
ETHNOPHARMACOLOGICAL RELEVANCE: The root of Croton crassifolius has been used as a traditional Chinese medicine (TCM), called Radix Croton Crassifolius, and commonly known as "Ji Gu Xiang" in Chinese. Its medicinal value has been recorded in several medical books or handbooks, such as "Sheng Cao Yao Xing Bei Yao", "Ben Cao Qiu Yuan" and "Zhong Hua Ben Cao". It has been traditional employed for treating sore throat, stomach-ache, rheumatism and cancer. AIM OF THE STUDY: At present, there are limited studies on the evaluation of low-polarity extracts of roots in C...
March 13, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38489912/pik3r1-fusion-drives-chemoresistance-in-ovarian-cancer-by-activating-erk1-2-and-inducing-rod-and-ring-like-structures
#5
JOURNAL ARTICLE
Heidi Rausio, Alejandra Cervera, Vanina D Heuser, Gun West, Jaana Oikkonen, Elena Pianfetti, Marta Lovino, Elisa Ficarra, Pekka Taimen, Johanna Hynninen, Rainer Lehtonen, Sampsa Hautaniemi, Olli Carpén, Kaisa Huhtinen
Gene fusions are common in high-grade serous ovarian cancer (HGSC). Such genetic lesions may promote tumorigenesis, but the pathogenic mechanisms are currently poorly understood. Here, we investigated the role of a PIK3R1-CCDC178 fusion identified from a patient with advanced HGSC. We show that the fusion induces HGSC cell migration by regulating ERK1/2 and increases resistance to platinum treatment. Platinum resistance was associated with rod and ring-like cellular structure formation. These structures contained, in addition to the fusion protein, CIN85, a key regulator of PI3K-AKT-mTOR signaling...
March 14, 2024: Neoplasia: An International Journal for Oncology Research
https://read.qxmd.com/read/38488021/-retracted-tanshinone-iia-enhances-the-inhibitory-effect-of-imatinib-on-proliferation-and-motility-of-acute-leukemia-cell-line-tib%C3%A2-152-in%C3%A2-vivo-and-in%C3%A2-vitro-by-inhibiting-the-pi3k-akt-mtor-signaling-pathway
#6
Zhi Teng, Shijuan Xu, Qin Lei
Following the publication of the above article, a concerned reader drew to the Editor's attention that the Transwell cell invasion assay data featured in Figs. 2D and 4E, certain of the tumor images in Fig. 5A and the TUNEL assay data in Fig. 5C were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published elsewhere prior to the submission of this paper to Oncology Reports , or which under consideration for publication at around the same time (some papers of which have been retracted)...
May 2024: Oncology Reports
https://read.qxmd.com/read/38487164/off-label-use-of-baricitinib-improves-moderate-and-severe-atopic-dermatitis-in-china-through-inhibiting-mapk-and-pi3k-akt-mtor-pathway-via-targeting-jak-stat-signaling-of-cd4-cells
#7
JOURNAL ARTICLE
Shuang Chen, Caihua Li, Zeng Tu, Tao Cai, Xinying Zhang, Lei Wang, Ruoyuan Tian, Jinglan Huang, Yuxuan Gong, Xiaotong Yang, Zetong Wu, Sirong He, Wenyan He, Dan Wang
As an inflammatory disease with a disrupted immune system, cytokine disorders in atopic dermatitis (AD) are closely related to the abnormal activation of JAK-STAT signal pathway. The critical relevance of the JAK-STAT signaling pathway to the pathogenesis of AD provides a strong rationale for JAK inhibitor research. Baricitinib, a small-molecule oral JAK inhibitor, has been proven to inhibit JAK-STAT signaling in a variety of diseases, including AD. It is currently available in China for off-label use. However, its efficacy in China and its mechanism are rarely reported...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38486405/gw9508-ameliorates-cognitive-dysfunction-via-autophagy-pathway-in-streptozotocin-induced-mouse-model-of-alzheimer-s-disease
#8
JOURNAL ARTICLE
Yanan Wang, Jingjing Chen, Chen Wang, Tong Chen, Ling He
BACKGROUND: G protein-coupled receptor 40 (GPR40) is a potential drug target for Alzheimer's disease (AD), and its agonist GW9508 ameliorates cognitive impairment by intravenous administration. OBJECTIVES: The present study was conducted to investigate the efficacy of GW9508 administered peripherally on cognitive dysfunction in streptozotocin (STZ)-induced AD mice. METHODS: Seventy male ICR mice were randomly divided into seven groups: vehicle sham group, model, Donepezil, GW9508-L, GW9508-M, GW9508-H, and GW1100 + GW9508-H groups, and administered either vehicle (artificial cerebrospinal fluid [aCSF]) or STZ (3 mg/kg in the vehicle) once a day (9:00 a...
March 14, 2024: Fundamental & Clinical Pharmacology
https://read.qxmd.com/read/38485945/linc00707-regulates-autophagy-and-promotes-the-progression-of-triple-negative-breast-cancer-by-activation-of-pi3k-akt-mtor-pathway
#9
JOURNAL ARTICLE
Hongli Li, Qinghua Liu, Yaqiong Hu, Chonggao Yin, Yunxiang Zhang, Peng Gao
Triple-negative breast cancer (TNBC) is a pathological subtype of breast cancer (BC) with high malignancy, strong invasiveness and poor prognosis. Long non-coding RNA (LncRNA) plays an important role during tumorigenesis. We identified that Linc00707 was upregulated in TNBC tissues by TCGA database and RT-qPCR assay, compared with normal breast tissues and other subtypes of BC. Linc00707 promoted TNBC cells proliferation, migration and invasion. Furthermore, we found that knockdown of Linc00707 influenced autophagy via PI3K/AKT/mTOR signaling pathway in TNBC cells...
March 14, 2024: Cell Death Discovery
https://read.qxmd.com/read/38484929/antidepressant-effects-of-esketamine-via-the-bdnf-akt-mtor-pathway-in-mice-with-postpartum-depression-and-their-offspring
#10
JOURNAL ARTICLE
Han Qin, Miao Yu, Nianjiao Han, Meilin Zhu, Xia Li, Jing Zhou
Postpartum depression (PPD) is a serious mental health problem that can negatively affect future generations. BDNF/AKT/mTOR signaling in the frontal lobe and hippocampus in mice is associated with depression, but its role in mice with PPD and their offspring is unknown. This study was aimed at investigating the effects of esketamine (ESK), a drug approved for treatment of refractory depression, on the BDNF/AKT/mTOR pathway in mice with PPD and their offspring. A model of chronic unpredictable mild stress with pregnancy was used...
March 13, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://read.qxmd.com/read/38483766/investigation-of-the-mutual-crosstalk-between-er-stress-and-pi3k-akt-mtor-signaling-pathway-in-iron-overload-induced-liver-injury-in-chicks
#11
JOURNAL ARTICLE
Xiang-Long Lv, Wen-Lei Li, Feng-Jiao Sun, Yu-Zhi An, Ning Sun, Xiao-Ping Lv, Xue-Li Gao
Iron is an essential element for the normal functioning of living organisms, but excessive iron deposition can lead to organ damage. This study aims to investigate the interaction between the endoplasmic reticulum stress signaling pathway and the PI3K/AKT/mTOR signaling pathway in liver injury induced by iron overload in chicks. Rspectively, 150 one-day-old broilers were divided into three groups and supplemented with 50 (C), 500 (E1), and 1000 (E2) mg ferrous sulfate monohydrate/kg in the basal diet. Samples were taken after continuous feeding for 14 days...
March 14, 2024: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://read.qxmd.com/read/38482051/gypenoside-induces-apoptosis-by-inhibiting-the-pi3k-akt-mtor-pathway-and-enhances-t-cell-antitumor-immunity-by-inhibiting-pd-l1-in-gastric-cancer
#12
JOURNAL ARTICLE
Hongliang Wu, Wenjing Lai, Qiaoling Wang, Qiang Zhou, Rong Zhang, Yu Zhao
Introduction: Gypenoside is a natural extract of Gynostemma pentaphyllum (Thunb.) Makino, a plant in the Cucurbitaceae family. It has been reported to have antitumor effects on the proliferation, migration and apoptosis of various types of cancer cells. However, the use of gypenoside in the treatment of gastric cancer has not been studied. In the present study, we explored the therapeutic effect of gypenoside on gastric cancer and the potential molecular mechanism. Methods and Results: Our results showed that gypenoside induced apoptosis in HGC-27 and SGC-7901 cells in a time-dependent and dose-dependent manner...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38481330/network-pharmacology-and-molecular-docking-analysis-on-shenfu-qiangxin-indicate-mtor-is-a-potential-target-to-treat-heart-failure
#13
JOURNAL ARTICLE
Peilin Zou, Jiajun Li, Yucong Zhang, Zonghao Qian, Hao Nie, Ni Yang, Le Zhang, Li Lin, Dewei Peng, Cuntai Zhang
BACKGROUND: Heart failure (HF) is one of the major causes of mortality worldwide with high recurrence rate and poor prognosis. Our study aimed to investigate potential mechanisms and drug targets of Shenfu Qiangxin (SFQX), a cardiotonic-diuretic traditional Chinese medicine, in treating HF. METHODS: An HF-related and SFQX-targeted gene set was established using disease-gene databases and the Traditional Chinese Medicine Systems Pharmacology database. We performed gene function and pathway enrichment analysis and constructed protein-protein interaction (PPI) network to investigate the potential mechanisms...
March 13, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38480916/p53-modulates-kinase-inhibitor-resistance-and-lineage-plasticity-in-nf1-related-mpnsts
#14
JOURNAL ARTICLE
Jamie L Grit, Lauren E McGee, Elizabeth A Tovar, Curt J Essenburg, Emily Wolfrum, Ian Beddows, Kaitlin Williams, Rachael T C Sheridan, Joshua L Schipper, Marie Adams, Menusha Arumugam, Thomas Vander Woude, Sharavana Gurunathan, Jeffrey M Field, Julia Wulfkuhle, Emanuel F Petricoin, Carrie R Graveel, Matthew R Steensma
Malignant peripheral nerve sheath tumors (MPNSTs) are chemotherapy resistant sarcomas that are a leading cause of death in neurofibromatosis type 1 (NF1). Although NF1-related MPNSTs derive from neural crest cell origin, they also exhibit intratumoral heterogeneity. TP53 mutations are associated with significantly decreased survival in MPNSTs, however the mechanisms underlying TP53-mediated therapy responses are unclear in the context of NF1-deficiency. We evaluated the role of two commonly altered genes, MET and TP53, in kinome reprograming and cellular differentiation in preclinical MPNST mouse models...
March 13, 2024: Oncogene
https://read.qxmd.com/read/38479634/neuroprotective-effects-of-cordycepin-on-mptp-induced-parkinson-s-disease-mice-via-suppressing-pi3k-akt-mtor-and-mapk-mediated-neuroinflammation
#15
JOURNAL ARTICLE
Linhai Wang, Shu Tian, Sisi Ruan, Jingjing Wei, Sijia Wei, Weiwei Chen, Hangcui Hu, Weiwei Qin, Yan Li, Hang Yuan, Jian Mao, Yan Xu, Jianping Xie
Parkinson's disease (PD) is a prevalent progressive and multifactorial neurodegenerative disorder. Cordycepin is known to exhibit antitumor, anti-inflammatory, antioxidative stress, and neuroprotective effects; however, few studies have explored the neuroprotective mechanism of cordycepin in PD. Using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model, we investigated the impact of cordycepin on PD and its underlying molecular mechanisms. The findings indicated that cordycepin significantly mitigated MPTP-induced motor dysfunction and neuroapoptosis, diminished the loss of dopaminergic neurons in the striatum-substantia nigra pathway, elevated striatal monoamine levels and its metabolites, and increased the levels of striatal monoamine and its metabolites, and inhibited the polarization of microglia and the expression of pro-inflammatory factors...
March 11, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38479552/hypoxia-induced-trem1-promotes-mesenchymal-like-states-of-glioma-stem-cells-via-alternatively-activating-tumor-associated-macrophages
#16
JOURNAL ARTICLE
Minhai Dong, Xiaolin Zhang, Peng Peng, Zirong Chen, Yang Zhang, Lijun Wan, Wang Xiang, Guohao Liu, Yang Guo, Qungen Xiao, Baofeng Wang, Dongsheng Guo, Min Zhu, Xingjiang Yu, Feng Wan
The mesenchymal subtype of glioblastoma (GBM) cells characterized by aggressive invasion and therapeutic resistance is thought to be dependent on cell-intrinsic alteration and extrinsic cellular crosstalk. Tumor-associated macrophages (TAMs) are pivotal in tumor progression, chemo-resistance, angiogenesis, and stemness maintenance. However, the impact of TAMs on the shifts in glioma stem cells (GSCs) states remains largely uncovered. Herein, we showed that the triggering receptor expressed on myeloid cells-1 (TREM1) preferentially expressed by M2-like TAMs and induced GSCs into mesenchymal-like states by modulating the secretion of TGFβ2, which activated the TGFβR/SMAD2/3 signaling in GSCs...
March 11, 2024: Cancer Letters
https://read.qxmd.com/read/38478219/transcriptome-analysis-of-an-akt-inhibitor-resistant-endometrial-cancer-cell-line
#17
JOURNAL ARTICLE
Takafumi Onishi, Tsuyoshi Takashima, Kazuki Shibahara, Shoji Takagi, Shinichi Tanaka, Michihiro Mori, Hirokazu Odashima, Yukihiko Osawa, Manabu Hattori
BACKGROUND: Drug resistance in endometrial cancer (EC) is a serious problem and a barrier to improving prognosis. The PI3K/AKT/mTOR pathway is highly activated in EC and can serve as a potential therapeutic target. Inhibitors against AKT have been developed, but resistance to these inhibitors is a concern. This study aimed to establish AKT inhibitor resistant cell lines and identify differentially expressed genes (DEGs) between parental and AKT inhibitor resistant cell lines to understand the mechanism of drug resistance to AKT inhibitors in EC...
March 13, 2024: Pharmacological Reports: PR
https://read.qxmd.com/read/38477554/expression-of-concern-conjugation-of-substituted-naphthalimides-to-polyamines-as-cytotoxic-agents-targeting-the-akt-mtor-signal-pathway
#18
Zhi-Yong Tian, Song-Qiang Xie, Zi-Hou Mei, Jin Zhao, Wen-Yuan Gao, Chao-Jie Wang
Expression of Concern for 'Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway' by Zhi-Yong Tian et al. , Org. Biomol. Chem. , 2009, 7 , 4651-4660, https://doi.org/10.1039/B912685F.
March 13, 2024: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38476887/paclitaxel-mediates-the-pi3k-akt-mtor-pathway-to-reduce-proliferation-of-flt3%C3%A2-itd-aml-cells-and-promote-apoptosis
#19
JOURNAL ARTICLE
Yanyun Su, Meiqing Wu, Baowen Zhou, Ziwen Bai, Ruli Pang, Zhenfang Liu, Weihua Zhao
Acute myeloid leukemia (AML) with internal tandem duplication (ITD) mutations in the FLT3 tyrosine kinase tend to have a poor prognosis. FLT3-ITD can promote the progress of AML by activating the PI3K/AKT/mTOR pathway. Paclitaxel (PTX) is a natural anticancer drug that has been widely used in chemotherapy for multiple malignancies. The present study used the CCK-8 assay, flow cytometry, PCR and western blotting to explore the anti-leukemia effect and possible mechanisms of PTX on MV4-11 cells with the FLT3-ITD mutation and the underlying mechanism...
April 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38474604/effects-and-mechanisms-of-luteolin-a-plant-based-flavonoid-in-the-prevention-of-cancers-via-modulation-of-inflammation-and-cell-signaling-molecules
#20
REVIEW
Saleh A Almatroodi, Ahmad Almatroudi, Hajed Obaid A Alharbi, Amjad Ali Khan, Arshad Husain Rahmani
Luteolin, a flavonoid, is mainly found in various vegetables and fruits, including carrots, cabbages, onions, parsley, apples, broccoli, and peppers. Extensive research in vivo and in vitro has been performed to explore its role in disease prevention and treatment. Moreover, this compound possesses the ability to combat cancer by modulating cell-signaling pathways across various types of cancer. The studies have confirmed that luteolin can inhibit cancer-cell survival and proliferation, angiogenesis, invasion, metastasis, mTOR/PI3K/Akt, STAT3, Wnt/β-catenin, and cell-cycle arrest, and induce apoptosis...
February 29, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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